A multi-chamber bag making process

Abstract

A multi-chamber bag manufacturing process includes the following steps: S1. Prepare a multi-chamber bag: Form a partition virtual weld mark by virtually welding the partition area between the first chamber and the second chamber on two infusion films. Virtually weld a tail virtual weld mark on the side of the first chamber away from the partition virtual weld mark. Virtually weld or actually weld the two sides of the first chamber adjacent to the partition virtual weld mark. Actually weld the periphery of the second chamber and weld an interface tube; S2. Fill and seal: Pour the liquid medicine into the second chamber through the interface tube, and then seal the combination cap and the interface tube; S3. Sterilize and dry the multi-chamber bag; S4. Fill with powder and seal: Cut and remove part of the tail virtual weld mark to form a filling port, pour the medicine powder into the first chamber through the filling port, and then weld the filling port; S5. Weld barrier films on both sides of the first chamber. The present invention is beneficial to reducing the deformation of the powder chamber, making the high-temperature sterilization loading method of the liquid chamber simple and stable, and making it easier to realize the powder filling process mechanism and the welding high-barrier film process mechanism of the powder chamber.

Description

Technical Field

[0001] The invention relates to the technical field of food and medicine packaging methods, and in particular to a multi-chamber bag making process. Background Art

[0002] The powder-liquid double chamber bag for large infusion products needs to be made of infusion plastic film (non-PVC multi-layer co-extruded film). The infusion plastic film is easy to deform under high temperature, especially when the bag body is fully welded around the body (after real welding, the two films are very firmly bonded and not easy to disassemble. In contrast, after virtual welding, the film is generally firmly bonded and can be disassembled under external force). The deformation is large. At present, the bag making and filling process of powder-liquid double chamber bag for large infusion products is mainly to first virtual weld the virtual welding mark of the middle powder-liquid chamber that is easy to disassemble, and then real weld around the bag making and forming bag (the liquid chamber needs to be sterilized after filling the liquid, so the powder chamber needs to be sealed before sterilization). Due to the high temperature of the real welding of the bag making and forming mold, the powder chamber is easily deformed, making the subsequent high-temperature sterilization loading method of the liquid chamber, the powder filling process of the powder chamber, and the high-barrier film welding process of the powder chamber difficult, with low production capacity and low pass rate. Summary of the invention

[0003] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a multi-chamber bag making process that is beneficial to reducing the deformation of the powder chamber, making the high-temperature sterilization loading method of the liquid chamber simple and stable, and making the powder filling process mechanism of the powder chamber and the welding high-barrier film process mechanism easier to implement.

[0004] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0005] A multi-chamber bag making process comprises the following steps:

[0006] S1. Prepare a multi-chamber bag: virtual weld the separation area between the first chamber and the second chamber on two infusion films to form a virtual weld mark, virtual weld the side of the first chamber away from the virtual weld mark to form a tail virtual weld mark, virtual weld or real weld the two sides of the first chamber adjacent to the virtual weld mark, and real weld the periphery of the second chamber and weld the mouth tube;

[0007] S2, filling and sealing: the liquid medicine is poured into the second chamber through the mouth tube, and then the cover and the mouth tube are combined to seal;

[0008] S3, sterilize and dry the multi-chamber bag;

[0009] S4, powder filling and sealing: cutting and removing part of the virtual welding marks at the tail to form a filling port, the powder is poured into the first chamber through the filling port, and then the filling port is welded;

[0010] S5. Welding barrier film: Weld barrier films on both sides of the first chamber.

[0011] As a further improvement of the above technical solution: the welding temperature corresponding to the separated virtual welding mark is T1, the welding temperature corresponding to the tail virtual welding mark is T2, and the welding temperature of the solid welding is T3, and T3 is greater than T1 and T2.

[0012] As a further improvement of the above technical solution: 100°C ≤ T1 ≤ 120°C.

[0013] As a further improvement of the above technical solution: T2 ≤ T1.

[0014] As a further improvement of the above technical solution: 120°C < T3 ≤ 170°C.

[0015] As a further improvement of the above technical solution: in step S4, the remaining tail virtual welding marks are also welded, and the filling port and the remaining tail virtual welding marks are subjected to virtual welding.

[0016] As a further improvement of the above technical solution: in step S5, the barrier film on one side of the first chamber is subjected to solid welding, and the barrier film on the other side is subjected to virtual welding.

[0017] As a further improvement of the above technical solution: in step S1, there are at least two separated virtual welding marks, and an isolation zone is formed between the two separated virtual welding marks.

[0018] As a further improvement of the above technical solution: in step S1, at least one first hanging hole is punched at the tail virtual welding mark.

[0019] As a further improvement of the above technical solution: in step S4, a second hanging hole is punched at the welded filling port, and a modified fillet is punched at the welded tail virtual welding mark; or, in step S4, a second hanging hole is punched at the welded filling port, and in step S5, after welding the barrier film, a modified fillet is punched at the tail virtual welding mark.

[0020] Compared with the prior art, the advantages of the present invention are as follows: in the multi-chamber bag making process disclosed by the present invention, when preparing a multi-chamber bag, first, the side of the first chamber far from the separated virtual welding mark is locally subjected to virtual welding or the periphery of the first chamber is integrally subjected to virtual welding. On the premise of ensuring that the tail virtual welding mark is not damaged during the high-temperature sterilization of the liquid medicine in the subsequent second chamber, the virtual welding is carried out at a temperature as low as possible, overcoming the problem of deformation of the first chamber. The loading method for the high-temperature sterilization of the liquid medicine in the subsequent second chamber becomes simple and stable, and the powder filling process mechanism and the welding barrier film process mechanism of the first chamber are easier to implement, improving the production capacity and qualification rate of the multi-chamber bag, and the operation is simple. Description of the Drawings

[0021] Figure 1 It is a schematic flow chart of the multi-chamber bag making process of the present invention.

[0022] Figure 2 Yes Figure 1 Schematic diagram of the structure where the first hanging hole is not punched at the tail soldering defect in b.

[0023] Figure 3 Yes Figure 1 Schematic diagram of the structure where the first hanging hole is not punched at the tail soldering defect in f.

[0024] Figure 4 Yes Figure 1 Schematic diagram of the structure where the second hanging hole is not punched at the filling port in f.

[0025] Figure 5 Yes Figure 1 Schematic diagram of the structure where different forms of mouth tubes are replaced in f.

[0026] In the figure, each reference numeral represents: 1, infusion film; 2, multi-chamber bag; 20, solid soldering mark; 21, powder chamber; 22, liquid chamber; 23, partition soldering defect; 24, tail soldering defect; 25, liquid medicine; 26, filling port; 27, medicine powder; 28, isolation belt; 291, first hanging hole; 292, second hanging hole; 293, modified fillet; 3, mouth tube; 4, combined cap. Detailed implementation manners

[0027] As shown in this part and the claims, unless the context clearly indicates otherwise, words such as "a", "an", "one" and / or "the" are not specifically singular and may also include the plural. The words "first", "second" and similar terms used in this part do not indicate any order, quantity or importance, but are only used to distinguish different components. Similarly, words such as "comprising" or "including" mean that the elements or objects appearing before this word cover the elements or objects listed after this word and their equivalents, without excluding other elements or objects. Words such as "connected" or "linked" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.

[0028] The present invention will be further described in detail below in conjunction with the accompanying drawings of the specification and specific embodiments.

[0029] Figures 1 to 5 An embodiment of the multi-chamber bag manufacturing process of the present invention is shown. The multi-chamber bag manufacturing process of this embodiment includes the following steps:

[0030] S1. Prepare the multi-chamber bag 2: The partition area corresponding to the first chamber 21 and the second chamber 22 on two pieces of infusion film 1 is soldered in a virtual manner to form a partition soldering defect 23, and the side of the first chamber 21 away from the partition soldering defect 23 is soldered in a virtual manner to form a tail soldering defect 24 (specifically refer to Figure 1a1, the tail virtual weld mark 24 is located on the upper side), the first chamber 21 is virtually welded on both sides adjacent to the partition virtual weld mark 23 (see specifically Figure 1 a2, that is, the left and right sides of the tail virtual weld mark 24 are connected to or actually welded to the partition virtual weld mark 23), the periphery of the second chamber 22 is actually welded and the mouth tube 3 (see specifically Figure 1 b and Figure 2 ). When the left and right sides of the tail virtual weld mark 24 are connected to the partition virtual weld mark 23, the actual weld marks 20 on the left and right sides of the second chamber 22 do not exceed the partition virtual weld mark 23. If the left and right sides of the tail virtual weld mark 23 are not connected to the partition virtual weld mark 23, the actual weld marks 20 on the left and right sides of the second chamber 22 extend to the tail virtual weld mark 24; among them, the form of the mouth tube 3 can be various, specifically as Figure 5 shown;

[0031] S2. Liquid filling and sealing: The liquid medicine 25 is filled into the second chamber 22 through the mouth tube 3, and then the combination cap 4 is sealed with the mouth tube 3 (see specifically Figure 1 c);

[0032] S3. Sterilize and dry the multi-chamber bag 2;

[0033] S4. Powder filling and sealing: Cut off a part of the tail virtual weld mark 24 to form a filling port 26, fill the medicine powder 27 into the first chamber 21 through the filling port 26, and then weld the filling port 26 (see specifically Figure 1 d to Figure 1 f. In this embodiment, it is to cut the upper side of the tail virtual weld mark 24. Of course, in other embodiments, the left and right sides of the tail virtual weld mark 24 can also be cut);

[0034] S5. Weld the barrier film: Weld the barrier film (not shown in the figure, preferably an aluminum film) on both side surfaces of the first chamber 21.

[0035] In the multi-chamber bag manufacturing process of this embodiment, when preparing the multi-chamber bag, first locally virtually weld one side of the first chamber 21 away from the partition virtual weld mark 23 or virtually weld the whole periphery of the first chamber 21. On the premise of ensuring that the tail virtual weld mark 24 is not damaged during the high-temperature sterilization of the liquid medicine 25 in the subsequent second chamber 22, perform virtual welding at as low a temperature as possible, overcome the problem of deformation of the first chamber 21, the loading method of the liquid medicine 25 in the subsequent second chamber 22 during high-temperature sterilization becomes simple and stable, the powder filling process mechanism and the welding barrier film process mechanism of the first chamber 21 are easier to implement, improve the production capacity and qualification rate of the multi-chamber bag, and the operation is simple.

[0036] Further, in this embodiment, the soldering temperature corresponding to the separated virtual soldering mark 23 is T1, the soldering temperature corresponding to the tail virtual soldering mark 24 is T2, and the soldering temperature for actual soldering is T3, where T3 is greater than T1 and T2. The higher actual soldering temperature is beneficial to ensuring a firm bond between the infusion films 1; the lower virtual soldering temperature is convenient for controlling the deformation amount of the infusion films 1 and facilitates disassembly during use.

[0037] As a preferred embodiment, 100°C ≤ T1 ≤ 120°C, which is beneficial to reducing the deformation amount of the infusion film 1 and facilitates disassembly during use.

[0038] As a preferred embodiment, T2 < T1, which is beneficial to reducing the deformation amount at the tail of the first chamber 21. Of course, in other embodiments, T1 and T2 can also be the same.

[0039] As a preferred embodiment, 120°C < T3 ≤ 170°C, which is beneficial to ensuring a firm bond between the infusion films 1 while minimizing damage to the tail virtual soldering mark 24.

[0040] Further, in this embodiment, in step S4, the remaining tail virtual soldering mark 24 is also soldered, and the filling port 26 and the remaining tail virtual soldering mark 24 are subjected to virtual soldering. Re-soldering the remaining tail virtual soldering mark 24 is beneficial to eliminating the damage caused to the remaining tail virtual soldering mark 24 during the formation of the filling port 26 by cutting, making the process more reliable; using virtual soldering is beneficial to controlling the deformation amount of the first chamber 21 to a minimum, and at the same time, when actually soldering the barrier film subsequently, it can eliminate the defect that the virtual soldering is prone to disassembly under force, and the process is reasonable and effective.

[0041] Further, in this embodiment, in step S5, the barrier film on one side of the first chamber 21 is subjected to actual soldering, and the remaining tail virtual soldering mark 24 and the virtual soldering mark at the filling port 26 are further soldered into an actual soldering mark through high-temperature actual soldering, eliminating the defect that the virtual soldering mark is prone to disassembly under force, and the process is reasonable and effective. The barrier film on the other side is subjected to virtual soldering, so that the product can be conveniently torn off the barrier film during clinical application.

[0042] As a preferred embodiment, in step S1, there are at least two separated virtual soldering marks 23, and an isolation band 28 is formed between the two separated virtual soldering marks 23, which can effectively separate the first chamber 21 and the second chamber 22.

[0043] As a preferred embodiment, in step S1, a first hanging hole 291 can be punched on each side of the tail virtual soldering mark 24, which is convenient for product clinical trials.

[0044] Of course, in other embodiments, in step S4, a second hanging hole 292 can also be punched at the soldered filling port 26, and a modified rounded corner 293 can be punched at the soldered tail virtual soldering mark 24;

[0045] Alternatively, in step S4, a second hanging hole 292 is punched at the filling port 26 after welding. In step S5, after the barrier film is welded, a modified rounded corner 293 is punched at the tail virtual welding mark 24.

[0046] Although the present invention has been disclosed above with preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make many possible changes and modifications to the technical solution of the present invention by using the technical content disclosed above, or modify it into an equivalent embodiment with equivalent changes. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the technical solution of the present invention shall fall within the scope of protection of the technical solution of the present invention.

Claims

1. A multi-chamber bag making process, characterized in that: It includes the following steps: S1. Prepare a multi-chamber bag (2): On two infusion films (1), a separation virtual weld mark (23) is formed by virtual welding in the separation area corresponding to the first chamber (21) and the second chamber (22). A tail virtual weld mark (24) is formed by virtual welding on the side of the first chamber (21) away from the separation virtual weld mark (23). The two sides of the first chamber (21) adjacent to the separation virtual weld mark (23) are either virtually welded or actually welded. The periphery of the second chamber (22) is actually welded and a mouth tube (3) is welded; S2. Fill with liquid and seal: The liquid medicine (25) is filled into the second chamber (22) through the mouth tube (3), and then the combination cap (4) is sealed with the mouth tube (3); S3. Sterilize and dry the multi-chamber bag (2); S4. Fill with powder and seal: Part of the tail virtual weld mark (24) is cut off to form a filling port (26). The medicinal powder (27) is filled into the first chamber (21) through the filling port (26), and then the filling port (26) is welded; S5. Weld the barrier film: The barrier film is welded on both sides of the first chamber (21).

2. The multi-chamber bag making process according to claim 1, wherein: The welding temperature corresponding to the separation virtual weld mark (23) is T1, the welding temperature corresponding to the tail virtual weld mark (24) is T2, and the welding temperature for actual welding is T3. T3 is greater than T1 and T2.

3. The multi-chamber bag making process according to claim 2, wherein: 100℃≤T1≤120℃。 4. The multi-chamber bag making process according to claim 2, characterized in that: T2 ≤ T1.

5. The multi-chamber bag making process according to claim 2, characterized in that: 120℃＜T3≤170℃。 6. The multi-chamber bag making process according to any one of claims 1 to 5, characterized in that: In step S4, the remaining tail virtual weld mark (24) is also welded. The filling port (26) and the remaining tail virtual weld mark (24) are virtually welded.

7. The multi-chamber bag making process according to claim 6, characterized in that: In step S5, the barrier film on one side of the first chamber (21) is actually welded, and the barrier film on the other side is virtually welded.

8. The multi-chamber bag making process according to any one of claims 1 to 5, characterized in that: In step S1, there are at least two separation virtual weld marks (23), and an isolation zone (28) is formed between two adjacent separation virtual weld marks (23).

9. The multi-chamber bag making process according to any one of claims 1 to 5, characterized in that: In step S1, at least one first hanging hole (291) is punched at the tail virtual weld mark (24).

10. The multi-chamber bag making process according to any one of claims 1 to 5, characterized in that: In step S4, a second hanging hole (292) is punched at the welded filling port (26), and a modified rounded corner (293) is punched at the welded tail virtual weld mark (24); or, in step S4, a second hanging hole (292) is punched at the welded filling port (26), and in step S5, after welding the barrier film, a modified rounded corner (293) is punched at the tail virtual weld mark (24).

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