A cold sediment automatic post-processing instrument and a preparation method of cold sediment blood coagulation factors

Abstract

The application discloses a cold deposit full-automatic post-processing instrument and a preparation method of cold deposit blood clotting factors. The cold deposit full-automatic post-processing instrument comprises a separation system, the separation system comprises a squeezing disc and a weighing disc, and the squeezing disc is provided with a squeezing cavity; a transportation tensioning system can transport the first blood bag to the squeezing cavity, transport the second blood bag to the weighing disc, cut the pipeline of the double-pipe and tighten the double-pipe; a heat sealing system can heat seal the first heat sealing point, the second heat sealing point, the third heat sealing point and the fourth heat sealing point on the tightened double-pipe; a material head removing system, the transportation tensioning system can transport the double blood bag after heat sealing to the material head removing system to remove the Y-shaped material head; and a collection system comprising a first collection box and a second collection box. The application can improve the heat sealing efficiency of the blood bag, improve the working environment and shorten the exposure time of the plasma at room temperature.

Description

Technical Field

[0001] This invention relates to the field of blood bag processing technology, and in particular to a fully automated post-processing instrument for cryoprecipitate and a method for preparing cryoprecipitate coagulation factors. Background Technology

[0002] Cryoprecipitate (CFR) coagulation factors include a large number of coagulation factors VIII, von Willebrand factor, fibrin, and fibronectin. It is mainly used for hemophilia A, von Willebrand disease, and congenital or acquired fibrinogen deficiency. It is also commonly used to treat postoperative bleeding, severe trauma, and disseminated intravascular coagulation (DIC). Currently, the preparation method for CFR involves using a doublet blood bag to separate fresh frozen plasma into one bag of CFR coagulation factors and one bag of frozen plasma to be cryoprecipitated. The bag of fresh frozen plasma to be cryoprecipitated is placed in a CFR coagulation factor preparation instrument at 1-6 degrees Celsius. The empty bag is allowed to hang naturally, and preparation is carried out according to the "Operating Procedure for CFR Coagulation Factor Preparation Instrument." The supernatant (i.e., pale yellow plasma) is separated into the empty bag, leaving 40-50 ml of plasma in the cryoprecipitate at the bottom of the blood bag; this is the CFR coagulation factor. Currently, the entire process mainly uses a semi-automatic production method, resulting in low separation efficiency and a poor working environment. Prolonged exposure of plasma to room temperature can easily lead to a decrease in plasma activity. Summary of the Invention

[0003] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention proposes a fully automated post-processing device for cryoprecipitate, which can improve the heat-sealing efficiency of blood bags, improve the working environment, and shorten the exposure time of plasma at room temperature.

[0004] The present invention also proposes a fully automated post-processing instrument for the above-mentioned cold precipitation.

[0005] According to a first aspect of the present invention, an automated post-processing instrument for cryoprecipitate is used for heat-sealing double blood bags. The double blood bags include a first blood bag containing plasma and an empty second blood bag. The first and second blood bags are connected by a double tube. A Y-shaped feed head is provided in the middle of the double tube. The double tube has four points requiring heat sealing, which are, in sequence, a first heat sealing point, a second heat sealing point, a third heat sealing point, and a fourth heat sealing point from the first blood bag to the second blood bag.

[0006] The separation system includes a squeezing disc and a weighing disc. The squeezing disc is provided with a squeezing chamber, which can squeeze the first blood bag that has been placed inside.

[0007] The transport tensioning system is capable of transporting the first blood bag to the squeezing chamber, transporting the second blood bag to the weighing pan, and cutting off the pipe of the double tube and tightening the double tube after separation is completed.

[0008] The heat sealing system is capable of heat sealing the first, second, third, and fourth heat sealing points on the stretched double tube;

[0009] The decanting system, wherein the transport tensioning system can transport the heat-sealed double blood bags to the decanting system to remove the Y-shaped decanting head, thereby separating the first blood bag and the second blood bag;

[0010] The collection system includes a first collection box and a second collection box, and the transport tensioning system is capable of transporting the separated first blood bag and second blood bag to the first collection box and the second collection box, respectively.

[0011] The fully automated post-processing instrument for cryoprecipitate according to embodiments of the present invention has at least the following beneficial effects: the entire process of double-unit blood bags, from feeding, separation, heat sealing, removal of the feeding head, and separate storage, is fully automated, improving work efficiency and reducing the number of personnel required. The continuous operation of the entire process shortens the time the blood bags are exposed to room temperature, reducing the possibility of plasma inactivation.

[0012] According to some embodiments of the present invention, the transport tensioning system includes;

[0013] The conveying mechanism includes a first clamping device and a second clamping device. The first clamping device and the second clamping device can clamp on the double tube and are respectively clamped on the outside of the first heat sealing point and the fourth heat sealing point. They can transport the first blood bag to the squeezing chamber and the second blood bag to the weighing pan. The clamping force of the first clamping device and the second clamping device can be adjusted.

[0014] The tensioning mechanism includes a third clamping device and a fourth clamping device, which clamp the double tube. The third clamping device is clamped between the first heat-sealing point and the second heat-sealing point, and the fourth clamping device is clamped between the third heat-sealing point and the fourth heat-sealing point. The third clamping device and the fourth clamping device can move towards each other to tension the clamped double tube.

[0015] According to some embodiments of the present invention, a feeding system is also included, the feeding system comprising two parallel transmission tracks, the transmission tracks having a plurality of grooves arranged along the conveying direction, the distance between the two transmission tracks being adapted to the length of the double tube so that the transported double tube is in a straight line, the transmission tracks having a material picking position for the transport tensioning system to clamp, the first clamping device and the second clamping device being able to clamp the double tube at the material picking position.

[0016] According to some embodiments of the present invention, a first wiping device is also included, which can wipe the duplex tube before heat sealing to remove moisture from the duplex tube.

[0017] According to some embodiments of the present invention, a first wiping device is further included. The first wiping device includes an absorbent base plate, an absorbent pressure plate, a downward driving device, and a lateral driving device. The absorbent base plate is disposed between the two transmission tracks and below the double-tube being transmitted. The absorbent pressure plate is disposed between the two transmission tracks and above the double-tube being transmitted. The downward driving device and the absorbent pressure plate are driven to drive the absorbent pressure plate to move towards the absorbent base plate. The lateral driving device and the absorbent pressure plate are driven to drive the absorbent pressure plate to reciprocate along the length direction of the double-tube.

[0018] According to some embodiments of the present invention, a second wiping device is also included, which can wipe the first blood bag and the second blood bag entering the separation system to remove moisture from the first blood bag and the second blood bag.

[0019] According to some embodiments of the present invention, a second wiping device is further included. The second wiping device includes two wiping modules, which are respectively disposed on the outer sides of the two transmission tracks. Each wiping module includes two wiping plates disposed opposite to each other. The two wiping plates are parallel and opposite to each other along the conveying direction of the transmission tracks. The two wiping plates form a blood bag transmission channel for the passage of the first blood bag or the second blood bag. The two wiping plates can move towards each other to adjust the width of the blood bag transmission channel.

[0020] According to some embodiments of the present invention, a material sensor is provided on the transmission track to detect when the double tube enters the material feeding position. The material sensor is electrically connected to the transmission track to control the opening and closing of the transmission track.

[0021] According to some embodiments of the present invention, the de-material head system includes a pulling device and a de-material clamp, the de-material clamp being disposed on the pulling device, the transport tensioning system being able to transport the Y-shaped material head to the de-material clamp and be clamped by the de-material clamp, the pulling device driving the de-material clamp to pull the Y-shaped material head to break the Y-shaped material head.

[0022] The method for preparing cryoprecipitate coagulation factor according to a second aspect of the present invention includes the fully automated cryoprecipitate post-processing instrument described above, and performs separation and heat sealing through the following steps:

[0023] Step S100, feeding and wiping: The double blood bags are placed one by one into the groove of the conveying track, and the double blood bags are transported to the picking position by the conveying track for the conveying tensioning system to clamp. During the transportation process, the double blood bags are wiped by the first wiping device to remove the moisture on the double tube, and the first blood bag and the second blood bag are wiped by the second wiping device to remove the moisture on the first blood bag and the second blood bag.

[0024] Step S200, Separation: The transport tensioning system removes the double blood bag from the material receiving position, transports the first blood bag to the squeezing chamber, and transports the second blood bag to the weighing pan. The squeezing chamber squeezes the first blood bag, causing the air and upper plasma in the first blood bag to enter the second blood bag, until the weight of the second blood bag reaches the set value.

[0025] Step S300, heat sealing: After separation, the transport tensioning system cuts off the pipe of the double tube to prevent plasma from continuing to flow through the double tube and tightens the double tube. Then, the heat sealing system heat seals the first heat sealing point, the second heat sealing point, the third heat sealing point and the fourth heat sealing point on the tightened double tube.

[0026] Step S400, Removal of the head: The transport tensioning system transports the double blood bag to the removal of the head system, and the removal of the head system removes the Y-shaped head, so that the first blood bag and the second blood bag are separated;

[0027] Step S500, Separate storage: The transport tensioning system transports the separated first blood bag and second blood bag to the first collection box and the second collection box respectively.

[0028] The method for preparing cryoprecipitate clotting factor according to embodiments of the present invention has at least the following beneficial effects: the entire process of double blood bags, from feeding, separation, heat sealing, removal of the feeding head, and separate storage, is fully automated, improving work efficiency and reducing the number of personnel required. During operation, the first blood bag, the second blood bag, and the double tube can be automatically wiped dry, ensuring the quality of heat sealing and the accuracy of separation during weighing. Simultaneously, reducing water droplets in the working environment improves the working environment.

[0029] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0030] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:

[0031] Figure 1This is a schematic diagram of the structure of a double blood bag;

[0032] Figure 2 A stereoscopic view of a fully automated post-processing instrument for cold precipitation according to an embodiment of the present invention. Figure 1 (The water-absorbing pressure plate is not shown);

[0033] Figure 3 A stereoscopic view of a fully automated post-processing instrument for cold precipitation according to an embodiment of the present invention. Figure 2 ;

[0034] Figure 4 for Figure 1 A magnified view of a portion of the image;

[0035] Figure 5 This is a plan view of a fully automated cold precipitation post-processing instrument according to an embodiment of the present invention.

[0036] Icon labels:

[0037] Double blood bag 100; First blood bag 110; Second blood bag 120; Double tube 130; Y-shaped feed head 140; First heat sealing point 131; Second heat sealing point 132; Third heat sealing point 133; Fourth heat sealing point 134;

[0038] Separation system 200; extrusion disc 210; extrusion chamber 211; weighing disc 220;

[0039] Transport tensioning system 300; first clamping device 310; second clamping device 320; third clamping device 330; fourth clamping device 340; three-axis motion frame 350;

[0040] Heat sealing system 400;

[0041] 500; 510; 520;

[0042] Collection system 600; First collection box 610; Second collection box 620;

[0043] Feeding system 700; Conveyor track 710; Groove 711; Material pick-up position 720; Material sensor 730;

[0044] First wiping device 800; absorbent base plate 810; absorbent pressure plate 820; downward pressure drive device 830; lateral drive device 840;

[0045] Second wiping device 900; wiping module 910; wiping plate 911; blood bag transfer channel 920. Detailed Implementation

[0046] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0047] In the description of this invention, it should be understood that the orientation descriptions, such as up, down, etc., are based on the orientation or positional relationship shown in the drawings and are only for the convenience of describing this invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0048] In the description of this invention, "multiple" refers to two or more. The use of "first" and "second" is for distinguishing technical features only and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features or their sequential relationship.

[0049] In the description of this invention, unless otherwise explicitly defined, terms such as "set up," "install," and "connect" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this invention in conjunction with the specific content of the technical solution.

[0050] Reference Figure 1 and Figure 2 As shown, this invention discloses a fully automated post-processing instrument for cryoprecipitate, used for heat-sealing double blood bags 100. The double blood bag 100 includes a first blood bag 110 containing plasma and an empty second blood bag 120. The first blood bag 110 and the second blood bag 120 are connected by a double-connecting tube 130. A Y-shaped feed head 140 is provided in the middle of the double-connecting tube 130. The double-connecting tube 130 has four heat-sealing points, sequentially designated as a first heat-sealing point 131, a second heat-sealing point 132, a third heat-sealing point 133, and a fourth heat-sealing point 134 from the first blood bag 110 to the second blood bag 120. The heat-sealing points include:

[0051] The separation system 200 includes a squeezing plate 210 and a weighing plate 220. The squeezing plate 210 is provided with a squeezing chamber 211, which can squeeze the first blood bag 110 that is placed in it.

[0052] The transport tensioning system 300 can transport the first blood bag 110 to the squeezing chamber 211 and the second blood bag 120 to the weighing pan 220. After the separation is completed, it can cut off the pipe of the double tube 130 and tighten the double tube 130.

[0053] The heat sealing system 400 is capable of heat sealing the first heat sealing point 131, the second heat sealing point 132, the third heat sealing point 133 and the fourth heat sealing point 134 on the stretched double tube 130;

[0054] The de-feeding head system 500 and the transport tensioning system 300 can transport the heat-sealed double blood bags 100 to the de-feeding head system 500 to remove the Y-shaped head 140 and separate the first blood bag 110 and the second blood bag 120.

[0055] The collection system 600 includes a first collection box 610 and a second collection box 620, and the transport tensioning system 300 is capable of transporting the separated first blood bag 110 and second blood bag 120 to the first collection box 610 and the second collection box 620, respectively.

[0056] Understandably, during use, the first blood bag 110 is transported to the compression chamber 211 and the second blood bag 120 is transported to the weighing pan 220 via the transport tensioning system 300.

[0057] The squeezing chamber 211 squeezes the first blood bag 110, causing the air above the first blood bag 110 and the upper plasma to flow into the second blood bag 120 through the double tube 130. The weighing pan 220 can weigh the plasma entering the second blood bag 120 until the weight of the second blood bag 120 reaches the preset value.

[0058] The weighing pan 220 uses electronic induction weighing with an accuracy of ±0.5g. When the weighing pan 220 reaches the set value, typically 75g, the squeezing chamber 211 stops squeezing. The squeezing pan 210 includes two pairs of squeezing plates, forming a squeezing chamber 211 between them. A servo motor drives the two squeezing plates to move towards each other, thereby adjusting the volume of the squeezing chamber 211 and squeezing the first blood bag 110 within it. After squeezing is complete, the squeezing chamber 211 expands further to facilitate the removal of the first blood bag 110.

[0059] After the separation system 200 completes the separation of plasma, the transport tensioning system 300 cuts off the tubing of the twin tube 130 to prevent plasma from continuing to flow along the tubing. Subsequently, the transport tensioning system 300 tightens the twin tube 130, so that the heat sealing system 400 can heat seal the first heat sealing point 131, the second heat sealing point 132, the third heat sealing point 133, and the fourth heat sealing point 134 on the tightened twin tube 130.

[0060] Heat sealing can be performed at four different locations. This can be achieved either by moving the hot welding head of the heat sealing system 400 between the four heat sealing points, or by moving the double pipe 130 through the transport tensioning system 300, so that the four different heat sealing points can be moved to the position of the hot welding head of the heat sealing system 400 to heat seal the first heat sealing point 131, the second heat sealing point 132, the third heat sealing point 133, and the fourth heat sealing point 134.

[0061] After heat sealing is completed, the transport tensioning system 300 transports the heat-sealed double blood bag 100 to the material removal system 500, which removes the Y-shaped material head 140, thus separating the first blood bag 110 and the second blood bag 120.

[0062] Subsequently, the transport tensioning system 300 transports the separated first blood bag 110 and second blood bag 120 to the first collection box 610 and the second collection box 620 respectively, completing one workflow. Then, the transport tensioning system 300 grabs and loads materials again, starting the next work cycle.

[0063] Understandably, in this embodiment, the entire process of the dual blood bag 100, from feeding, separation, heat sealing, removal of the feeding head, and separate storage, is fully automated, improving work efficiency and reducing the need for manpower. The continuous operation of the entire process shortens the time the blood bags are exposed to room temperature, reducing the possibility of plasma inactivation.

[0064] Reference Figure 2 and Figure 4 As shown, in some embodiments of the present invention, the transport tensioning system 300 includes;

[0065] The conveying mechanism includes a first clamping device 310 and a second clamping device 320. The first clamping device 310 and the second clamping device 320 can clamp onto the double tube 130 and are respectively clamped on the outside of the first heat sealing point 131 and the fourth heat sealing point 134. They can transport the first blood bag 110 to the squeezing chamber 211 and the second blood bag 120 to the weighing pan 220. The clamping force of the first clamping device 310 and the second clamping device 320 can be adjusted.

[0066] The tensioning mechanism includes a third clamping device 330 and a fourth clamping device 340, which clamp the double tube 130. The third clamping device 330 is clamped between the first heat-sealing point 131 and the second heat-sealing point 132, and the fourth clamping device 340 is clamped between the third heat-sealing point 133 and the fourth heat-sealing point 134. The third clamping device 330 and the fourth clamping device 340 can move towards each other to tension the clamped double tube 130.

[0067] Understandably, during material handling, the first clamping device 310 and the second clamping device 320 clamp the double-ended tube 130, respectively, on the outside of the first heat-sealing point 131 and the fourth heat-sealing point 134. The clamping force of the first clamping device 310 and the second clamping device 320 is adjusted to a smaller value to clamp the double-ended tube 130 without cutting it, thus facilitating separation. After separation, the clamping force is adjusted to a larger value to cut off the double-ended tube 130, enabling heat sealing.

[0068] During heat sealing, the third clamping device 330 is clamped between the first heat sealing point 131 and the second heat sealing point 132, and the fourth clamping device 340 is clamped between the third heat sealing point 133 and the fourth heat sealing point 134. At the same time, the third clamping device 330 and the fourth clamping device 340 move towards each other to tension the clamped double tube 130.

[0069] It should be noted that the clamping force of the third clamping device 330 and the fourth clamping device 340 can also be adjusted. During transfer, the third clamping device 330 and the fourth clamping device 340 can also clamp the double tube 130 without cutting it off. The double tube 130 is then cut off after separation is completed.

[0070] In this embodiment, to facilitate the movement of the first clamping device 310, the second clamping device 320, the third clamping device 330, and the fourth clamping device 340, all four devices are mounted on a three-axis motion frame 350. This allows for movement in the X, Y, and Z axes, enabling the movement of the double-tube 130 during various operations such as feeding, separating, heat sealing, removing the material head, and separating for storage.

[0071] In this embodiment, the first clamping device 310 and the third clamping device 330 are mounted on the same mounting base, and the first clamping device 310 and the third clamping device 330 can move simultaneously. Similarly, the second clamping device 320 and the fourth clamping device 340 are mounted on the same mounting base.

[0072] In this embodiment, the heat sealing system 400 includes two heat sealing machines. The three-axis motion frame 350 clamps the double tube 130 above the heat sealing position through the first clamping device 310, the second clamping device 320, the third clamping device 330 and the fourth clamping device 340.

[0073] The two heat sealing machines first move to the lower right side of the double-pipe 130, where it descends to the heat sealing head to complete the heat sealing of the first heat sealing point 131 and the second heat sealing point 132. After completion, the grippers lift the double-pipe 130 upwards, away from the heat sealing head. The two heat sealing machines then move to the lower left side of the double-pipe 130, where the grippers lower the pipe again to the heat sealing head to complete the heat sealing of the third heat sealing point 133 and the fourth heat sealing point 134. After completion, the grippers lift the double-pipe 130 back to its original heat sealing position. The two heat sealing machines have a travel distance of 270 mm, and the sliding table allows for simultaneous movement of the two machines at different heat sealing positions.

[0074] refer to Figure 2 and Figure 3 As shown, in some embodiments of the present invention, a feeding system 700 is also included. The feeding system 700 includes two parallel transmission tracks 710. The transmission tracks 710 are provided with a plurality of grooves 711 arranged along the conveying direction. The distance between the two transmission tracks 710 is adapted to the length of the double tube 130 so that the transported double tube 130 is in a straight line. The transmission track 710 is provided with a picking position 720 for the transport tensioning system 300 to clamp. The first clamping device 310 and the second clamping device 320 can clamp the double tube 130 located at the picking position 720.

[0075] When it is understandable, the double blood bag 100 is transported to the picking position 720 by the feeding system 700 for the first clamping device 310 and the second clamping device 320 to pick it up.

[0076] Specifically, when placing the double blood bag 100, both ends of the double tube 130 are placed in the grooves 711 of the corresponding transmission track 710. The distance between the two transmission tracks 710 and the length of the double tube 130 are matched so that the transported double tube 130 is in a straight line. This ensures that the double blood bag 100 is transported to the picking position 720 with the double tube 130 in a straight line, which facilitates the first clamping device 310 and the second clamping device 320 to clamp it.

[0077] In this embodiment, the transmission track 710 is provided with several grooves 711 arranged along the conveying direction, which can feed about 20 bags at a time and can continuously feed materials to ensure the continuous operation of heat sealing.

[0078] refer to Figure 2 and Figure 3 As shown, in some embodiments of the present invention, a first wiping device 800 is also included, which can wipe the double tube 130 before heat sealing to remove moisture from the double tube 130.

[0079] If water adheres to the double tube 130, it will affect the subsequent heat sealing effect. Based on this, this embodiment sets up a first wiping device 800 to wipe the double tube 130 before heat sealing, remove the moisture on the double tube 130, and ensure the effect of subsequent heat sealing.

[0080] refer to Figure 2 and Figure 3 As shown, in some embodiments of the present invention, a first wiping device 800 is also included. The first wiping device 800 includes a water-absorbing base plate 810, a water-absorbing pressure plate 820, a downward driving device 830, and a lateral driving device 840. The water-absorbing base plate 810 is disposed between two transmission tracks 710 and located below the double pipe 130 being transmitted. The water-absorbing pressure plate 820 is disposed between two transmission tracks 710 and located above the double pipe 130 being transmitted. The downward driving device 830 and the water-absorbing pressure plate 820 are connected in a transmission manner to drive the water-absorbing pressure plate 820 to move towards the water-absorbing base plate 810. The lateral driving device 840 and the water-absorbing pressure plate 820 are connected in a transmission manner to drive the water-absorbing pressure plate 820 to reciprocate along the length direction of the double pipe 130.

[0081] Understandably, during transport along the conveyor track 710, the double tube 130 passes between the absorbent base plate 810 and the absorbent pressure plate 820. When wiping the double tube 130, the conveyor track 710 stops moving, and the absorbent pressure plate 820 moves downward under the action of the downward pressure drive device 830, clamping the double tube 130 between the absorbent base plate 810 and the absorbent pressure plate 820. The absorbent base plate 810 and the absorbent pressure plate 820 themselves have water absorption properties and can absorb the moisture adhering to the surface of the double tube 130.

[0082] Meanwhile, to ensure effective water removal, the transverse drive device 840 drives the water-absorbing pressure plate 820 to reciprocate along the length of the double pipe 130, repeatedly wiping the double pipe 130 to ensure its surface is dry. Both the water-absorbing base plate 810 and the water-absorbing pressure plate 820 can use a sponge layer as the absorbent layer, providing excellent water absorption and removal.

[0083] In a further embodiment, the water-absorbing base plate 810 and the water-absorbing pressure plate 820 are provided with strip grooves on their opposite surfaces. The strip grooves cooperate with the double tube 130. During the wiping and water removal process, the double tube 130 can fall into the strip grooves, and the entire outer surface of the double tube 130 is covered in the strip grooves. This increases the contact area between the strip grooves and the water-absorbing base plate 810 and the water-absorbing pressure plate 820, further ensuring the water removal effect.

[0084] It should be noted that during the heat sealing stage, the conveyor track 710 needs to stop moving and wait for the next material pick-up. Therefore, this process allows for the dehydration of the twin tubes 130, enabling the heat sealing and dehydration processes to proceed simultaneously without affecting the heat sealing stage.

[0085] Because the temperature of the double blood bag 100 is relatively low, there is a possibility that condensation may reappear on the surface of the double tubes 130 after wiping but before they are removed. In this embodiment, the absorbent plate 820 can wipe all the double tubes 130 located between the absorbent base plate 810 and the absorbent plate 820 each time it moves downwards to wipe, so even if condensation reappears on the double tubes 130, it can be removed.

[0086] The double blood bag 100 needs to be removed from a water bath at 1-6 degrees Celsius, and its surface is covered with water, which can easily cause water to drip everywhere in the working environment. At the same time, the first blood bag 110 and the second blood bag 120 are also covered with water. During the subsequent separation and weighing process, the presence of moisture will cause a large error in the weighing due to the presence of water.

[0087] Based on this, refer to Figure 3 and Figure 5 As shown, in some embodiments of the present invention, a second wiping device 900 is also included, which can wipe the first blood bag 110 and the second blood bag 120 entering the separation system 200 to remove moisture from the first blood bag 110 and the second blood bag 120.

[0088] In this embodiment, the first blood bag 110 and the second blood bag 120 entering the separation system 200 are wiped by the second wiping device 900 to remove moisture from the first blood bag 110 and the second blood bag 120, so as to avoid the water adhering to the first blood bag 110 and the second blood bag 120 and dripping into the working environment, as well as the impact on weighing.

[0089] refer to Figure 3 and Figure 5 As shown, in some embodiments of the present invention, a second wiping device 900 is also included. The second wiping device 900 includes two wiping modules 910, which are respectively disposed on the outer side of the two transmission tracks 710. Each wiping module 910 includes two wiping plates 911 arranged opposite to each other. The two wiping plates 911 are parallel and opposite to each other along the conveying direction of the transmission track 710. The two wiping plates 911 form a blood bag transmission channel 920 for the passage of the first blood bag 110 or the second blood bag 120. The two wiping plates 911 can move towards each other to adjust the width of the blood bag transmission channel 920.

[0090] During transport, the first blood bag 110 or the second blood bag 120 is suspended outside the two transport tracks 710. Accordingly, two wiping modules 910 are respectively positioned outside the two transport tracks 710. During transport, the first blood bag 110 or the second blood bag 120 passes through the corresponding blood bag transport channel 920. During this passage, it rubs against the two wiping plates 911, wiping away water from the passing blood bags 110 and 120. The two wiping plates 911 can move towards each other to adjust the width of the blood bag transport channel 920, thus adapting to the passing blood bags 110 and 120.

[0091] refer to Figure 2 As shown, in some embodiments of the present invention, a material sensor 730 is provided on the transmission track 710 to detect the entry of the double tube 130 into the material feeding position 720. The material sensor 730 is electrically connected to the transmission track 710 to control the opening and closing of the transmission track 710.

[0092] It is understood that in this embodiment, a material sensor 730 is set to detect whether the double tube 130 has entered the picking position 720. When the double tube 130 is present at the picking position 720, feedback is sent to the conveyor track 710 to stop the transmission. After the double tube 130 is picked up, feedback is sent to the conveyor track 710, and the conveyor track 710 continues to transmit forward, transporting the double tube 130 to the picking position 720, thereby realizing automatic control.

[0093] refer to Figure 2 and Figure 5 As shown, in some embodiments of the present invention, the de-material head system 500 includes a pulling device 510 and a de-material clamping claw 520. The de-material clamping claw 520 is disposed on the pulling device 510. The transport tensioning system 300 can transport the Y-shaped material head 140 to the de-material clamping claw 520 and clamp it. The pulling device 510 drives the de-material clamping claw 520 to pull the Y-shaped material head 140 to break it off.

[0094] Understandably, the transport tensioning system 300 moves the double blood bag 100 and transports the Y-shaped feed head 140 to the unloading gripper 520, where it clamps the Y-shaped feed head 140. The transport tensioning system 300 remains stationary, while the pulling device 510 moves away from the transport tensioning system 300, pulling the Y-shaped feed head 140 through the unloading gripper 520 until it breaks off. After the Y-shaped feed head 140 is broken off, the first blood bag 110 and the second blood bag 120 are separated and then transported by the transport tensioning system 300 into the first collection box 610 and the second collection box 620, respectively. The torn-off Y-shaped feed head 140 is then disposed of in the waste bin.

[0095] In this embodiment, the double blood bag 100 is moved by the first clamping device 310, the second clamping device 320, the third clamping device 330 and the fourth clamping device 340, and the Y-shaped material head 140 is fed into the unloading jaw 520.

[0096] In summary, the fully automated cryoprecipitate post-processing instrument of this invention can automatically separate cryoprecipitate clotting factors from cryoprecipitate-free frozen plasma, and automate the entire process of weighing, venting, wiping with water, and heat sealing, enabling batch operations and significantly improving production efficiency. It also shortens the time the blood is exposed to room temperature, thereby ensuring a cold chain environment for the blood, protecting the activity of cryoprecipitate clotting factors, and ensuring the efficacy of transfusions for patients.

[0097] Current cryoprecipitate (CFR) coagulation factor preparation processes primarily employ semi-automatic production methods, resulting in low efficiency in separation and heat sealing, particularly in the water wiping step. Because plasma bags require cryogenic storage, they must be removed from a 1-6 degree Celsius water bath during processing. The surface of the doubled blood bags becomes soaked with water, causing water to accumulate on staff clothing, shoes, equipment, and work surfaces throughout the process, potentially jeopardizing staff safety. Furthermore, if not thoroughly cleaned, water on the connecting tubing can interfere with heat sealing. Prolonged exposure to room temperature during the entire process can also lead to a decrease in plasma activity.

[0098] Based on this, the present invention also discloses a method for preparing cryoprecipitate coagulation factor, including the fully automated cryoprecipitate post-processing instrument described in the above embodiments, and performing separation and heat sealing through the following steps:

[0099] Step S100, feeding and wiping: The double blood bags 100 are placed one by one into the groove 711 of the transmission track 710. The double blood bags 100 are transported to the picking position 720 by the transmission track 710 for the transport tensioning system 300 to pick up. During the transport process, the double blood bags 100 are wiped by the first wiping device 800 to remove the moisture on the double tube 130. The first blood bag 110 and the second blood bag 120 are wiped by the second wiping device 900 to remove the moisture on the first blood bag 110 and the second blood bag 120.

[0100] Step S200, Separation: The transport tensioning system 300 takes away the double blood bag 100 from the material taking position 720, transports the first blood bag 110 to the squeezing chamber 211, and transports the second blood bag 120 to the weighing pan 220. The squeezing chamber 211 squeezes the first blood bag 110, so that the air and upper plasma in the first blood bag 110 enter the second blood bag 120, until the weight of the second blood bag 120 reaches the set value.

[0101] Step S300, heat sealing: After separation, the transport tensioning system 300 cuts off the tubing of the double tube 130 to prevent plasma from continuing to flow through the double tube 130 and tightens the double tube 130. Subsequently, the heat sealing system 400 heat seals the first heat sealing point 131, the second heat sealing point 132, the third heat sealing point 133 and the fourth heat sealing point 134 on the tightened double tube 130.

[0102] Step S400, Removal of head: The transport tensioning system 300 transports the double blood bag 100 to the head removal system 500, and the head removal system 500 removes the Y-shaped head 140, so that the first blood bag 110 and the second blood bag 120 are separated.

[0103] Step S500, Separate storage: The transport tension system transports the separated first blood bag 110 and second blood bag 120 to the first collection box 610 and the second collection box 620 respectively.

[0104] In this embodiment, the entire process of loading, separating, heat-sealing, removing the feed head, and storing the dual blood bags 100 is fully automated, improving work efficiency and reducing the need for manpower. During operation, the system automatically wipes and removes water from the first blood bag 110, the second blood bag 120, and the dual tube 130, ensuring the quality of heat sealing and the accuracy of separation during weighing. Simultaneously, it reduces water dripping into the working environment, improving its condition. Furthermore, it shortens the time plasma is exposed to room temperature, minimizing its impact on plasma activity.

[0105] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention.

Claims

1. A fully automatic post-processing instrument for cryoprecipitate, used for heat-sealing double blood bags (100), the double blood bag (100) comprising a first blood bag (110) containing plasma and an empty second blood bag (120), the first blood bag (110) and the second blood bag (120) being connected by a double tube (130), the double tube (130) having a Y-shaped feed head (140) in the middle, the double tube (130) having four points requiring heat sealing, which, from the first blood bag (110) to the second blood bag (120), are sequentially a first heat sealing point (131), a second heat sealing point (132), a third heat sealing point (133), and a fourth heat sealing point (134), characterized in that, include: The separation system (200) includes a squeezing disc (210) and a weighing disc (220). The squeezing disc (210) is provided with a squeezing chamber (211), which can squeeze the first blood bag (110) that has been placed in it. The transport tensioning system (300) is capable of transporting the first blood bag (110) to the squeezing chamber (211), transporting the second blood bag (120) to the weighing pan (220), and cutting off the pipe of the double tube (130) and tightening the double tube (130) after separation is completed; The heat sealing system (400) is capable of heat sealing the first heat sealing point (131), the second heat sealing point (132), the third heat sealing point (133) and the fourth heat sealing point (134) on the stretched double tube (130); The head removal system (500) and the transport tensioning system (300) are capable of transporting the heat-sealed double blood bags (100) to the head removal system (500) to remove the Y-shaped head (140) and separate the first blood bag (110) and the second blood bag (120); The collection system (600) includes a first collection box (610) and a second collection box (620), and the transport tensioning system (300) is capable of transporting the separated first blood bag (110) and second blood bag (120) to the first collection box (610) and the second collection box (620) respectively; The feeding system (700) includes two parallel conveyor tracks (710). The first wiping device (800) includes a water-absorbing base plate (810), a water-absorbing pressure plate (820), a downward driving device (830), and a horizontal driving device (840). The water-absorbing base plate (810) is disposed between the two transmission tracks (710) and located below the double pipe (130) being transmitted. The water-absorbing pressure plate (820) is disposed between the two transmission tracks (710) and located above the double pipe (130) being transmitted. The downward driving device (830) and the water-absorbing pressure plate (820) are connected in a transmission manner to drive the water-absorbing pressure plate (820) to move towards the water-absorbing base plate (810). The horizontal driving device (840) and the water-absorbing pressure plate (820) are connected in a transmission manner to drive the water-absorbing pressure plate (820) to reciprocate along the length direction of the double pipe (130). The second wiping device (900) includes two wiping modules (910), which are respectively disposed on the outside of the two transmission tracks (710). Each wiping module (910) includes two wiping plates (911) arranged opposite to each other. The two wiping plates (911) are parallel and opposite to each other along the conveying direction of the transmission track (710). The two wiping plates (911) form a blood bag transmission channel (920) for the first blood bag (110) or the second blood bag (120) to pass through. The two wiping plates (911) can move towards each other to adjust the width of the blood bag transmission channel (920).

2. The fully automatic post-processing instrument for cold precipitation according to claim 1, characterized in that, The transport tensioning system (300) includes; The conveying mechanism includes a first clamping device (310) and a second clamping device (320). The first clamping device (310) and the second clamping device (320) can clamp on the double tube (130) and clamp on the outside of the first heat sealing point (131) and the fourth heat sealing point (134), respectively. They can transport the first blood bag (110) to the squeezing chamber (211) and the second blood bag (120) to the weighing pan (220). The clamping force of the first clamping device (310) and the second clamping device (320) can be adjusted. The tensioning mechanism includes a third clamping device (330) and a fourth clamping device (340), which clamp the double tube (130) on the double tube. The third clamping device (330) is clamped between the first heat-sealing point (131) and the second heat-sealing point (132), and the fourth clamping device (340) is clamped between the third heat-sealing point (133) and the fourth heat-sealing point (134). The third clamping device (330) and the fourth clamping device (340) can move towards each other to tension the clamped double tube (130).

3. The fully automatic post-processing instrument for cold precipitation according to claim 2, characterized in that, The transmission track (710) is provided with a plurality of grooves (711) arranged along the conveying direction. The distance between the two transmission tracks (710) is adapted to the length of the double tube (130) so that the transported double tube (130) is in a straight line. The transmission track (710) is provided with a material picking position (720) for the transport tensioning system (300) to clamp. The first clamping device (310) and the second clamping device (320) can clamp the double tube (130) located at the material picking position (720).

4. The fully automatic post-processing instrument for cold precipitation according to claim 1, characterized in that, It also includes a first wiping device (800) that can wipe the double tube (130) before heat sealing to remove moisture from the double tube (130).

5. The fully automatic post-processing instrument for cold precipitation according to claim 1, characterized in that, It also includes a second wiping device (900) that can wipe the first blood bag (110) and the second blood bag (120) entering the separation system (200) to remove moisture from the first blood bag (110) and the second blood bag (120).

6. The fully automatic post-processing instrument for cold precipitation according to claim 3, characterized in that, A material sensor (730) is provided on the transmission track (710) to detect when the double tube (130) enters the material feeding position (720). The material sensor (730) is electrically connected to the transmission track (710) to control the opening and closing of the transmission track (710).

7. The fully automatic post-processing instrument for cold precipitation according to claim 1, characterized in that, The destocking system (500) includes a pulling device (510) and a destocking clamp (520). The destocking clamp (520) is mounted on the pulling device (510). The transport tensioning system (300) can transport the Y-shaped material head (140) to the destocking clamp (520) and clamp it. The pulling device (510) drives the destocking clamp (520) to pull the Y-shaped material head (140) to break it off.

8. A method for preparing cryoprecipitate clotting factor, characterized in that, Includes the fully automated post-processing instrument for cold precipitation as described in any one of claims 1 to 7, and performs separation and heat sealing through the following steps: Step S100, loading and wiping: The double blood bags (100) are placed one by one into the groove (711) of the transmission track (710). The double blood bags (100) are transported to the picking position (720) by the transmission track (710) for the transport tensioning system (300) to pick up. During the transport process, the double blood bags (100) are wiped by the first wiping device (800) to remove the moisture on the double tube (130). The first blood bag (110) and the second blood bag (120) are wiped by the second wiping device (900) to remove the moisture on the first blood bag (110) and the second blood bag (120). Step S200, separation: The transport tensioning system (300) takes away the double blood bag (100) from the material taking position (720), and transports the first blood bag (110) to the squeezing chamber (211) and the second blood bag (120) to the weighing pan (220). The squeezing chamber (211) squeezes the first blood bag (110) that has been placed in, so that the air and the upper plasma in the first blood bag (110) enter the second blood bag (120) until the weight of the second blood bag (120) reaches the set value. Step S300, heat sealing: After separation, the transport tensioning system (300) cuts off the pipe of the double tube (130) to prevent the plasma from continuing to flow through the double tube (130) and tightens the double tube (130). Then, the heat sealing system (400) heat seals the first heat sealing point (131), the second heat sealing point (132), the third heat sealing point (133) and the fourth heat sealing point (134) on the tightened double tube (130). Step S400, Removal of the head: The transport tensioning system (300) transports the double blood bag (100) to the head removal system (500), and the head removal system (500) removes the Y-shaped head (140) to separate the first blood bag (110) and the second blood bag (120); Step S500, Separate storage: The transport tensioning system transports the separated first blood bag (110) and second blood bag (120) to the first collection box (610) and the second collection box (620) respectively.

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