Injection preparation kit and injection preparation system including the same

Abstract

The disclosed invention is an injection preparation kit, which includes: a cylinder barrel, which flows in and discharges external fluid through changes in cylinder volume caused by the relative fixation and rotation of a pair of pistons arranged inside; a first tube, which is connected to the outflow pipe of the cylinder barrel; a three-way valve, which selectively connects any one of the two inflow paths to the outflow path; a second tube, which connects the outflow path of the three-way valve to the inflow pipe of the cylinder barrel; a third tube, which is connected to the first inflow path of the three-way valve; and a fourth tube, which is connected to the second inflow path of the three-way valve.

Description

Technical Field

[0001] The present invention relates to an injection preparation kit and an injection preparation system including the same, and more specifically to an injection preparation kit and an injection preparation system, which are composed of a closed system that can minimize contamination from the external environment while reducing the workload and errors of the staff, thereby safely and accurately preparing and injecting the injection. Background Art

[0002] In medical settings, blood, compound sodium chloride injection, amino acid solution, glucose solution or medicines are usually injected into the patient's body as a form of supplementation therapy, deficiency disease prevention and treatment, for blood transfusion for excessive bleeding caused by illness, accident or surgery, or for diseases caused by infection, low immunity, or lack of water, electrolytes or nutrition in the body.

[0003] In order to inject blood, medicines and other injections (hereinafter collectively referred to as "injections") into patients in precise amounts and speeds according to the doctor's prescription, a syringe pump or an infusion pump is used. A syringe pump is a method of injecting the injection by applying pressure to the injection inside after pushing the plunger of the syringe, while an infusion pump is a method of injecting the injection into the patient by squeezing the infusion tube of the liquid medicine container suspended at a height that exerts appropriate gravity. In other words, syringe pumps and infusion pumps are distinguished and used according to the form and type of the container in which the injection is sterilized and sealed, and the action of pushing the plunger in the syringe pump and repeatedly pressing the infusion tube in the infusion pump are accurately achieved through the control of the motor, so that the injection dose, speed, time, etc. are carried out according to the prescription.

[0004] On the other hand, injections often contain toxic drugs such as anticancer agents or contrast agents. Anticancer agents and the like should be handled by professional pharmacists in the sterile preparation room, and professional pharmacists should wash their hands before entering the sterile preparation room and carefully wear personal protective equipment such as antibacterial clothing, antibacterial shoes, masks, hair caps, protective gloves, goggles, etc. In addition, in the sterile preparation room, the surrounding environment such as the workbench should be disinfected, the prescription of the handled drug should be accurately confirmed, and the syringe, injection needle, ampoule, etc. should be disinfected and discarded in the designated manner after use. In addition, the injection prepared in the sterile preparation room should be kept sterile and the seal should be removed before administering the drug to the patient to minimize the problem of contamination.

[0005] As mentioned above, the procedures for handling toxic drugs such as anticancer drugs are very complicated and strict, and even for well-trained pharmacists, direct handling of toxic substances by humans is always accompanied by difficulties and dangers. In addition, in order to mix several toxic drugs in one bag, complicated procedures must be repeated, and in this case, the possibility of errors or mistakes in the amount of input will also increase. In particular, it is difficult for pharmacists who are wrapped in various personal protective equipment to maintain concentration for a long time, so it would be an excessive burden to put the responsibility of preparing toxic drugs solely on pharmacists.

[0006] In the past, as a solution to this problem, an automated dispensing robot for mixed intravenous injections carrying cytotoxicity has been introduced. The automated dispensing robot is a method of automatically performing the following series of processes: a multi-jointed robotic arm is installed in an internal space that maintains a sterile environment, and based on the prescription information, it is classified by barcode scanning, and the multi-jointed robotic arm grabs a specific medicine and extracts the medicine with a syringe and injects it into the drug container for preparing the medicine. In other words, a multi-jointed robotic arm directly replaces the role of the previous practicing pharmacist.

[0007] However, the price of the device itself is very expensive compared to the operating rate, so only a few units are sold, with large hospitals with sufficient capital as the main customers. Therefore, for first-line medical institutions that prepare more than hundreds of thousands of anti-cancer drugs in a year, the limitations of mass dissemination are very obvious.

[0008]

Prior technical literature

[0009] [Patent Literature]

[0010] (Patent Document 1) Korean Patent Registration No. 10-0948632 (registered on March 12, 2010) Summary of the invention

[0011] The object of the present invention is to provide an injection preparation kit and an injection preparation system including the same, which includes the preparation of a combination of various drugs, especially toxic anticancer agents or contrast agents, etc., so that the preparation of injections that need to be carefully managed under strictly restricted conditions can be performed safely, hygienically and simply at a low cost.

[0012] The injection preparation kit according to the present invention includes: a cylinder barrel, which flows in and discharges external fluid through changes in the cylinder volume caused by the relative fixing and rotation operations of a pair of pistons arranged inside; a first tube, which is connected to the outflow pipe of the cylinder barrel; a three-way valve, which selectively connects any one of the two inflow paths to the outflow path; a second tube, which connects the outflow path of the three-way valve to the inflow pipe of the cylinder barrel; a third tube, which is connected to the first inflow path of the three-way valve; and a fourth tube, which is connected to the second inflow path of the three-way valve.

[0013] Here, an infusion bag is connected to the first tube and the second tube, and a drug container is connected to the fourth tube.

[0014] In addition, preferably, the fourth tube and the medicine container can be connected via an adapter having an air inflow function.

[0015] In addition, the present invention also includes at least one additional three-way valve, and the first inflow path and the outflow path of the additional three-way valve can also be connected to any one of the second to fourth tubes. In this case, an additional drug container is connected to the second inflow path of the additional three-way valve.

[0016] Furthermore, an infusion bag may be connected to the second inflow channel of the additional three-way valve, an empty infusion bag may be connected to the first tube and the third tube, and a drug container may be connected to the fourth tube.

[0017] In addition, the cylinder tube is characterized in that it has an upper rotating body and a lower rotating body that are freely rotatable with respect to each other, and an annular cylinder space is formed between the upper rotating body and the lower rotating body. In a pair of pistons, the first piston can rotate along the cylinder space by being connected to the upper rotating body, or the second piston can rotate along the cylinder space by being connected to the lower rotating body.

[0018] On the other hand, the present invention provides an injection preparation system, which includes an injection preparation kit having the structure described above and a cylinder pump, wherein the cylinder pump is equipped with a cylinder barrel of the injection preparation kit and independently drives a pair of pistons arranged inside the cylinder barrel.

[0019] The cylinder pump includes a cylinder driving unit that independently drives a pair of pistons provided in a cylinder tube and a control unit that controls the cylinder driving unit, and the control unit controls the amount and speed of liquid flowing in and out of the cylinder tube according to preset values.

[0020] In addition, the control unit controls the cylinder driving unit so that a predetermined amount of drug solution in the drug container connected to the fourth tube flows in and out to the infusion bag connected to the first tube.

[0021] Here, the second inflow channel connected to the fourth pipe and the outflow channel connected to the second pipe of the three-way valve are in an open state.

[0022] The cylinder drive unit includes a first drive unit for driving an upper rotating body of the cylinder tube and a second drive unit for driving a lower rotating body, and has a dual-axis structure in which a second drive shaft of the second drive unit enters into a first drive shaft of the first drive unit.

[0023] According to an embodiment of the present invention, the first driving part and the second driving part are respectively composed of worm gear transmission structures.

[0024] On the other hand, the present invention provides an injection preparation method, which includes: a first step of preparing an injection preparation kit of the above-mentioned structure, and connecting an infusion bag to a first tube and a third tube, and connecting a medicine container to a fourth tube; a second step of installing the cylinder barrel of the injection preparation kit on a cylinder pump, and the cylinder pump independently drives a pair of pistons arranged inside the cylinder barrel; a third step of inputting a quantity of medicine liquid in a medicine liquid container to be introduced into the infusion bag relative to the cylinder pump; a fourth step of opening a second inflow path connected to the fourth tube and an outflow path connected to the second tube relative to the three-way valve; and a fifth step of introducing the medicine liquid in the medicine container into the infusion bag according to a set quantity by driving the cylinder pump.

[0025] In addition, after step 5, in order to form a circulating flow path for infusion by operating the three-way valve, the first inflow path connected to the third tube and the outflow path connected to the second tube are opened, and the cylinder pump is operated so that the infusion in the infusion bag circulates through the cylinder barrel, so that all the remaining liquid medicine in the tube can be put into the infusion bag.

[0026] In addition, a filling step for removing air from the first to third tubes may be included between step 3 and step 4. The filling step is to open the first inflow path connected to the third tube and the outflow path connected to the second tube relative to the three-way valve, and circulate the infusion in the infusion bag through the cylinder barrel, thereby removing air from the first to third tubes.

[0027] According to the embodiment, the step of replacing the drug container with another additional drug container and driving the cylinder pump to introduce the drug solution in the additional drug container into the infusion bag in a set amount can be performed.

[0028] In addition, the first step includes the 1-1 step, connecting the first inflow path and the outflow path of at least one additional three-way valve to any one of the second to fourth tubes, and connecting the additional drug container to the second inflow path of the additional three-way valve, and after the 5th step, it may also include an additional mixing step, closing the outflow path of the drug container while opening the outflow path of the additional drug container, and driving the cylinder pump to introduce the drug solution in the additional drug container into the infusion bag according to the set amount.

[0029] On the other hand, step 1 includes step 1-1, connecting an empty infusion bag to the first tube and the third tube, connecting the first inflow path and the outflow path of at least one additional three-way valve to any one of the second to fourth tubes, connecting the infusion bag to the second inflow path of any one of the additional three-way valves, and steps 3 to 5 can also introduce the infusion of the infusion bag connected to the second inflow path of the additional three-way valve into the empty infusion bag according to a set amount, and then close the outflow path of the infusion bag while opening the outflow path of the drug container, thereby introducing the drug solution in the drug container into the empty infusion bag according to the set amount.

[0030] In addition, a finishing step may be added after step 5 to remove the chemical container and the fourth tube relative to the cylinder barrel and close the second inflow passage of the three-way valve, or to remove the chemical container, the fourth tube and the second tube and connect the third tube to the inflow tube.

[0031] Meanwhile, the injection preparation kit according to the present invention can also be used for the dissolution of powder medicines, and in this case, the injection preparation kit includes: a first tube connected to the outflow tube of the cylinder barrel; a powder medicine container connected to the first tube; a second tube connected to the inflow tube of the cylinder barrel; and a diluent bag connected to the second tube.

[0032] In addition, the present invention provides an injection preparation method, which includes: a first step of preparing the above-mentioned injection preparation kit for the powder medicine; a second step of installing the cylinder barrel of the injection preparation kit on a cylinder pump, and the cylinder pump independently drives a pair of pistons arranged inside the cylinder barrel; a third step of inputting a diluent in a diluent bag to be introduced into a powder medicine container relative to the cylinder pump; and a fourth step of introducing the diluent in the diluent bag into the powder medicine container according to a set amount by driving the cylinder pump.

[0033] When using the injection preparation kit of the present invention having the structure as described above, since the cylinder pump performs both the suction and discharge actions at the same time, the previous syringe operation can be automatically performed, reducing the intervention of the operator, greatly reducing the danger when handling toxic liquid medicines, and automatically performing accurate metering, thereby eliminating the worry of mistakes during preparation.

[0034] In addition, according to the prior art introduced above, during the process of preparing the injection, there is a moment of exposure to the external environment, so there is a concern about contamination or infection. However, the present invention performs all preparation processes while maintaining a closed system in the injection preparation kit. Therefore, the previous work of inserting and removing the injection needle disappears, which has the advantage of reducing the risk of contamination of the infusion bag. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1This is a diagram showing the overall structure of the applicant's prior patent cylinder pump.

[0036] Figure 2 It is shown installed on Figure 1 An exploded perspective view of the cylinder barrel of a cylinder pump.

[0037] Figure 3 It is shown installed on Figure 1 Diagram of the condition of the cylinder barrel of a cylinder pump.

[0038] Figure 4 About setting Figure 1 Diagram of the cylinder drive section of a cylinder pump.

[0039] Figure 5 About Figure 4 Exploded perspective view of the cylinder drive unit.

[0040] Figure 6 is a diagram showing the suction and discharge processes performed in the cylinder bore.

[0041] Figure 7 This is a diagram showing one embodiment of the injection preparation kit according to the present invention.

[0042] Figure 8 It is shown in Figure 7 A diagram showing changes in the flow path state of a three-way valve in an injection preparation kit.

[0043] Fig. 9 This is a diagram showing another embodiment of the injection preparation kit according to the present invention.

[0044] Fig.10 It is a figure which shows still another embodiment of the injection preparation kit according to the present invention.

[0045] Fig.11 It shows that Figure 7 A diagram of an embodiment of an injection preparation system in which an injection preparation kit is combined with a cylinder pump.

[0046] Fig.12 This is a diagram showing a state where finishing work is performed on the infusion bag after the preparation of the injection is completed.

[0047] Fig.13 This is a diagram showing another state in which finishing work is performed on the infusion bag after the injection preparation is completed.

[0048] Fig.14 It is a figure which shows the modification embodiment of the injection preparation kit according to this invention.

[0049] Description of symbols

[0050] 10: Injection preparation kit 100: Cylinder barrel

[0051] 110: Upper housing 112: Drive shaft insertion hole

[0052] 114: Upper rotating body 116: First drive shaft tight connection hole

[0053] 118: Upper tight connection part 120: Lower shell

[0054] 122: Lower rotating body 124: Second drive shaft tight connection hole

[0055] 126: Lower tight connection part 130: Cylinder space

[0056] 140: First piston 142: Second piston

[0057] 150: Inflow pipe 152: Outflow pipe

[0058] 200: Three-way valve 202: First inflow path

[0059] 204: Second inflow channel 206: Outflow channel

[0060] 210: Additional three-way valve 300: Drug container adapter

[0061] 310: First tube 320: Second tube

[0062] 330: Third tube 340: Fourth tube

[0063] 400: Infusion bag 402: Empty infusion bag

[0064] 404: diluent bag 410: medicine container

[0065] 420: Additional medicine container 430: Powder medicine container

[0066] 500: Cylinder pump 510: Cover

[0067] 512: Cylinder mounting groove 520: Cylinder drive unit

[0068] 522: driving shaft 530: first driving unit

[0069] 532: first drive motor 534: first worm

[0070] 536: First worm gear 538: First drive shaft

[0071] 540: Second driving unit 542: Second driving motor

[0072] 544: Second worm 546: Second worm wheel

[0073] 548: Second drive shaft 1000: Injection preparation system DETAILED DESCRIPTION

[0074] The present invention can be modified in many ways and has many embodiments, so specific embodiments are exemplified and described in detail in the specification. However, this is not intended to limit the specific implementation of the present invention, but should be understood to include all changes, equivalents and even substitutes within the scope of the present invention.

[0075] The terms used in the present invention are only used to illustrate specific embodiments and are not intended to limit the intention of the present invention. Singular expressions include plural expressions unless the context has a clearly different meaning. In this specification, terms such as "including" or "having" should be understood to specify the existence of the features, numbers, steps, actions, constituent elements, components or combinations thereof recorded in the specification, and do not exclude the existence or additional possibility of one or more other features or numbers, steps, actions, constituent elements, components or combinations thereof in advance.

[0076] Hereinafter, the preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. At this time, it should be noted that in the accompanying drawings, the same components are represented by the same reference numerals as much as possible. In addition, the detailed description of the known functions and structures that may obscure the gist of the present invention will be omitted. For the same reason, in the accompanying drawings, some components are exaggerated, omitted or schematically shown.

[0077] The present invention relates to an injection preparation kit 10 and an injection preparation system 1000 including the same, characterized in that the injection preparation kit 10 is constructed as a closed system, thereby minimizing contamination from the external environment and reducing the workload and mistakes of the staff, thereby safely and accurately preparing the injection, and the prepared injection preparation kit 10 can be immediately used on the patient in this state. Here, in order to explain the injection preparation kit 10 of the present invention, it is necessary to explain the cylinder pump 500 of the applicant's prior patent application. However, the structure of the cylinder pump 500 will be briefly explained within the limit required for understanding the present invention.

[0078] Figure 1 As a figure showing the overall appearance of the cylinder pump 500 of the prior patent application, the front cover 510 is in an open state. When the front cover 510 is opened, the Figure 2 The cylinder barrel 100 shown, Figure 3(b) shows a state where the cylinder barrel 100 is combined in the cylinder pump 500. For reference, the cylinder barrel 100 is fixed by an automatic locking function, and the cylinder barrel 100 combined with the drive shaft 522 is fixed in a form that does not move during operation. The following describes the cylinder barrel 100 and its drive unit 520 and its working principle.

[0079] Reference Figure 2 The cylinder barrel 100 is a structure formed by sealingly combining an upper shell 110 and a lower shell 120, and neatly arranged on the same axis so that the upper rotating body 114 and the lower rotating body 122 therein can rotate independently. The upper rotating body 114 and the lower rotating body 122 are respectively formed in the form of a truncated cone, and the vertex parts (vertices of the extended generatrix) of each truncated cone are arranged in a mutually facing manner, forming a concave space between the shells. The annular space is used as a cylinder space 130.

[0080] An upper fastening connection part 118 and a lower fastening connection part 126 are formed in an integrated form on the inclined surfaces of the upper and lower rotating bodies 122, and a first piston 140 is combined with the upper fastening connection part 118, and a second piston 142 is combined with the lower fastening connection part 126. The first piston 140 and the second piston 142 are made of a deformable material so that the rubber sealing ring combined with the end of the push rod of a conventional syringe has elasticity and fits tightly to the surrounding surface. In other words, the first piston 140 and the second piston 142 fit tightly to the inner circumferential surface of the outer shell, and according to the rotational movement of the first piston 140 or the second piston 142, negative pressure and positive pressure can be partially formed in the annular cylinder space 130. For reference, Figure 2 The annular component not shown with a reference numeral is a sealing component used for sealing.

[0081] In addition, the lower housing 120 is provided with an inflow tube 150 and an outflow tube 152, and an infusion tube is inserted into the inflow tube 150 and the outflow tube 152, respectively. In addition, a drive shaft insertion hole 112 is formed in the center of the upper housing 110, and a first drive shaft fastening connection hole 116 is formed in the upper rotating body 114 coaxial with the drive shaft insertion hole 112, and a second drive shaft fastening connection hole 124 is formed in the lower rotating body 122. Here, the first drive shaft fastening connection hole 116 is larger than the second drive shaft fastening connection hole 124. In other words, the second drive shaft fastening connection hole 124 can be approached through the first drive shaft fastening connection hole 116. In addition, the first drive shaft fastening connection hole 116 and the second drive shaft fastening connection hole 124 form a directional shape. In the illustrated embodiment, the first drive shaft fastening connection hole 116 forms a cross shape with different widths, and the second drive shaft fastening connection hole 124 forms a T-shaped shape.

[0082] from Figure 3 As shown in (a), a drive shaft 522 is shown in the central portion of the cylinder mounting groove 512, and a cylinder drive unit 520 disposed in the main body of the cylinder pump 500 is shown in FIG. Figure 4 and Figure 5 The cylinder driving unit 520 is provided with two driving motors, and the rotation axes of the first driving shaft 538 and the second driving shaft 548 operated by the respective driving motors are consistent. In addition, as a dual-axis structure in which the second driving shaft 548 is included in the first driving shaft 538, one driving shaft 522 is formed from the appearance.

[0083] Figure 5 : is an exploded perspective view of the cylinder driving unit 520. The first driving unit 530 and the second driving unit 540 are respectively composed of worm gear transmission structures. The first driving unit 530 includes a first driving motor 532, a first worm 534 coupled to the shaft of the first driving motor 532, a first worm wheel 536 meshing with the first worm 534, and a first driving shaft 538 extending in a direction perpendicular to the gear of the first worm wheel 536. The second driving motor 542, the second worm 544, the second worm wheel 546 and the second driving shaft 548 of the second driving unit 540 also form the same structure.

[0084] especially, Figure 5 The cylinder drive unit 520 forms a double-axis structure in which the second drive shaft 548 enters the first drive shaft 538. In other words, the first drive shaft 538 is a structure in which the second drive shaft 548 enters and further protrudes. Even if such a double-axis structure is formed, since the first drive unit 530 and the second drive unit 540 are worm gear transmission structures, even if either side of the first drive shaft 538 or the second drive shaft 548 rotates, the other drive shaft cannot be rotated. Therefore, the first drive shaft 538 and the second drive shaft 548 operate independently.

[0085] In addition, observe Figure 2 , Figure 4 and Figure 5, the outer surface of the first drive shaft 538 corresponds to the shape of the first drive shaft fastening connection hole 116 formed in the upper rotating body 114 of the cylinder barrel 100, and the end of the second drive shaft 548 corresponds to the shape of the second drive shaft fastening connection hole 124 formed on the lower rotating body 122. In addition, the first drive shaft fastening connection hole 116 is larger than the second drive shaft fastening connection hole 124, and the second drive shaft 548 protrudes more than the first drive shaft 538. Therefore, when the cylinder barrel 100 is installed in the barrel mounting groove 512, the second drive shaft 548 passes through the first drive shaft fastening connection hole 116 through the drive shaft insertion hole 112 of the cylinder barrel 100 and is fastened to the second drive shaft fastening connection hole 124 of the lower rotating body 122 located further inside, and the first drive shaft 538 is fastened to the first drive shaft fastening connection hole 116. Since the first drive shaft 538 and the second drive shaft 548 operate independently, the first piston 140 coupled to the upper rotating body 114 through the first drive unit 530 rotates independently, and the second piston 142 coupled to the lower rotating body 122 can also rotate independently through the second drive unit 540 .

[0086] Figure 6 The structure having this Figures 1 to 5 The working principle of the Cylinder Pump 500.

[0087] According to the cylinder pump 500 of the prior patent application, the first piston 140 and the second piston 142 of the cylinder barrel 100 are controlled to rotate by the operation of the driving unit 520, so that the injection (blood or liquid medicine, etc.) flows out through the cylinder barrel 100, that is, is injected into the patient's body. The suction and discharge of the injection as described above form an injection cycle and an alternating cycle.

[0088] For example, when the cylinder pump 500 is initially driven, the control unit of the cylinder pump 500 performs injection cycle control, such as Figure 6 As shown in (a), the second piston 142 is fixed between the inflow pipe 150 and the outflow pipe 152, and the first piston 140 located on the inflow pipe 150 side rotates counterclockwise, so that a negative pressure is formed in the cylinder space 130 between the first piston 140 and the second piston 142. Through this negative pressure, the injection agent flows into the cylinder barrel 100 through the inflow pipe 150.

[0089] In addition, if Figure 6 As shown in (b) and (c), the first piston 140 continues to rotate in the counterclockwise direction, so that the injection agent flows into the cylinder through the inlet pipe 150. In addition, the injection agent in the cylinder flows out to the outside of the cylinder barrel 100 through the outlet pipe 152. In this way, the injection agent continues to move (inflow and outflow).

[0090] Afterwards, when the first piston 140 rotates and Figure 6 When the cylinder is located at the outflow pipe 152 as shown in (d), the injection in the cylinder will not flow out to the outside. At this time, the control unit drives the first piston 140 and the second piston 142 at the same time. Figure 6 As shown in (e), the first piston 140 is located between the inflow pipe 150 and the outflow pipe 152 where the second piston 142 was previously located, and the second piston 142 is controlled to rotate in the counterclockwise direction. In other words, an alternating cycle control is implemented to change the functions (fixed and rotating) of the first piston 140 and the second piston 142.

[0091] After performing this alternating cycle control, when the first piston 140 is fixed, Figure 6 As shown in (f) and (g) of FIG. 1 , the second piston 142 is again rotated in the counterclockwise direction to perform injection cycle control. Figure 6 As shown in (h), when the second piston 142 rotates to the outflow pipe 152, the alternating cycle control is performed again, so that the functions of the first piston 140 and the second piston 142 are alternating.

[0092] As described above, the inflow and outflow of the injection agent performed by the injection cycle performed by the first piston 140 and the second piston 142 corresponds to the volume of the cylinder corresponding to the rotation angle of the rotating piston. Therefore, the rotation speed and rotation angle of the first drive motor 532 and the second drive motor 542 are controlled, so that the injection speed and injection amount of the injection agent discharged by the cylinder pump 500 can be accurately maintained (for example, the first drive motor 532 and the second drive motor 542 can be composed of encoder motors). In other words, the cylinder pump 500 described above can accurately control the flow rate and flow velocity of the injection agent passing through the cylinder barrel 100 according to the set value, which means that the cylinder pump 500 of the prior patent application has a fast push (Bo l us) function of accurately injecting the injection agent into the patient at a set injection speed and injection amount.

[0093] This cylinder pump 500 can not only accurately perform the rapid push injection function, but also has several other advantages. One of them is that the cylinder barrel 100 independently forms a closed system with the cylinder pump 500. In other words, with the cylinder barrel 100 as the center, the infusion tube and the injection bag are connected to the inflow tube 150 and the outflow tube 152, and any cylinder pump 500 can be installed and used. In a clean environment, if the cylinder barrel 100 and various drugs such as infusion sets and anticancer agents are prepared in the form of a kit to form a collected injection, it can be used at any time, so problems such as contamination or infection will be fundamentally improved.

[0094] Another advantage is that the operation of the cylinder pump 500 is realized by the rotation operation of the first piston 140 / second piston 142 provided in the cylinder tube 100. Therefore, there are the following great advantages: even if the syringe is used for a long time for more than several days by a patient like a conventional syringe pump, there is no need to replace the syringe, and in order to avoid the change of the injection amount caused by the deformation of the infusion tube like an infusion pump, there is no need to periodically adjust the position where the infusion tube is pressed, so it can be used continuously for a very long time without interruption.

[0095] The injection preparation kit 10 and the injection preparation system 1000 including the same according to the present invention are derived from the unique structure of the cylinder pump 500 developed by the applicant, wherein the cylinder pump 500 can accurately control the rapid push injection and the cylinder barrel 100 to form an independent closed system by actively sucking in and discharging the injection. Figure 7 One embodiment of an injection preparation kit 10 according to the present invention is shown.

[0096] Reference Figure 7 According to the injection preparation kit 10 of the present invention, the cylinder barrel 100 is used as the center, and several tubes and a three-way valve 200 are connected to form a structure in which an infusion bag 400 and a medicine container 410 to be mixed in the infusion of the infusion bag 400 are combined. With this injection preparation kit 10, a medicine liquid having the same dosage as the prescription can be accurately mixed in the infusion bag 400 (or a nutrient bag, etc., the most representative one is the infusion bag) to prepare an injection. In addition, the multiple tubes included in the injection preparation kit 10 can be made of a transparent material that can confirm the flow of the infusion and the medicine liquid, and generally, an infusion tube can be used.

[0097] The injection preparation kit 10 includes a cylinder barrel 100, which allows external fluid to flow in and out through changes in cylinder volume caused by relatively fixed and rotating operations of a pair of pistons 140, 142 disposed inside. The structure of the cylinder barrel 100 is the same as described above.

[0098] In addition, the first pipe 310 is connected to the outflow pipe 152 of the cylinder barrel 100, and the outflow passage 206 of the three-way valve 200 is connected to the inflow pipe 150 of the cylinder barrel 100 via the second pipe 320. The three-way valve 200 functions to selectively open or restrict the flow of the two inflow passages by connecting only one of the two inflow passages to the outflow passage 206. The third pipe 330 is connected to the first inflow passage 202 of the three-way valve 200, and the fourth pipe 340 is connected to the second inflow passage 204.

[0099] According to the structure of the injection preparation kit 10, although the liquid flows in one direction toward the outflow pipe 152 of the cylinder barrel 100 through the first pipe 310, only the flow of any one of the third pipe 330 and the fourth pipe 340 is selectively made to flow toward the inflow pipe 150 of the cylinder barrel 100 by the operation of the three-way valve 200. In other words, the two liquids selectively flow toward the inflow pipe 150 of the cylinder barrel 100, and any one of the flows selected as above is discharged through the outflow pipe 152.

[0100] In order to prepare an injection by accurately mixing a drug solution such as an anticancer agent of the same dose as the prescription into the infusion solution in the infusion bag 400, the first tube 310 and the third tube 330 are connected to the infusion bag 400, and the drug container 410 is connected to the fourth tube 340. Therefore, the infusion solution in the infusion bag 400 or the drug solution in the drug container 410 selectively flows to the inflow tube 150 of the cylinder tube 100. In addition, although it will be described later, the flow of the infusion solution flows out and flows in with respect to the infusion bag 400 at the same time, the flow of the drug solution is discharged only from the drug container 410, so in order to smoothly discharge the drug solution, it is necessary to eliminate the negative pressure in the drug container 410. For this reason, it is preferable that the fourth tube 340 and the drug container 410 are connected to the adapter 300 having an air inflow function. In addition, the adapter 300 has a function as a support for the drug container 410, so it is preferable to block the dangerous factor of separating the drug container 410 without knowing it.

[0101] In addition, if Fig. 9 As shown, an additional flow path for sequentially mixing two or more liquid medicines may be formed. The additional flow path includes a three-way valve 200, and the structure of the additional flow path may be expanded according to the number of additional medicine containers 420. The first inflow flow path and the outflow flow path of the additional three-way valve 210 are connected to any one of the second pipe 320, the third pipe 330, and the fourth pipe 340, and the additional medicine container 420 is connected to the second inflow flow path of the additional three-way valve 210. Thus, each medicine container 410 is arranged in parallel with the inflow pipe 150 of the cylinder barrel 100.

[0102] In addition, as Fig. 9 Other embodiments with the same basic structure may also be Fig.10 The injection preparation kit 10 is composed of. Fig.10 The embodiment of the present invention is characterized in that an empty infusion bag 402 is prepared, and an infusion and a drug such as an anticancer agent are sequentially introduced into the empty infusion bag 402 to complete the injection. In other words, the above embodiment has the following differences compared to the infusion bag 400 containing the infusion, in which a fixed amount of drugs are introduced and mixed: Fig.10 The embodiment of the present invention is to prepare an injection by quantitatively discharging medicine or even infusing the medicine through a cylinder pump 500.

[0103] Specifically, the infusion bag 400 is connected to the second inflow passage relative to the additional three-way valve 210, and the empty infusion bag 402 is connected to the first tube 310 and the third tube 330, and the drug container 410 is connected to the fourth tube 340. When preparing the injection, the infusion of the infusion bag 400 is introduced into the empty infusion bag 402 according to the quantitative amount of the prescription by opening the outflow passage of the additional three-way valve 210, and then the drug solution of the drug container 410 connected to the three-way valve 200 is also introduced into the empty infusion bag 402 according to the quantitative amount of the prescription (although the quantitative infusion has been introduced, the same terminology is continued to be used to distinguish the infusion bags) to complete the injection.

[0104] This Fig.10 The advantage of the embodiment is that when preparing an injection, there is no need to discharge excess infusion exceeding the prescribed amount from the infusion bag 400 and discard it in advance (the cylinder pump can discharge the exact amount), and the injection can be prepared according to the prescription. Fig.10 The embodiment also includes a structure of adding a three-way valve 210 and an additional drug container 420, so that Fig. 9 As shown, multiple liquid medicines can also be mixed.

[0105] Fig.11 The injection preparation system 1000 is shown in which the injection preparation kit 10 is installed on the cylinder pump 500. The injection preparation kit 10 is a kit formed by forming a closed system with the infusion bag 400 and the medicine container 410 around the cylinder 100. The injection preparation system 1000 can be said to be a system that uses the rapid push function of the cylinder pump 500 to accurately prepare the injection according to the prescription.

[0106] The injection preparation kit 10 itself is a complete kit, and all preparations for injection preparation are completed when only the cylinder barrel 100 of the injection preparation kit 10 is installed in the barrel installation groove 512 of the cylinder pump 500. The structure of the cylinder drive unit 520 of the cylinder pump 500 to activate the cylinder barrel 100 is as described above.

[0107] The cylinder pump 500 includes a control unit for controlling the cylinder driving unit 520, and the control unit can accurately control the amount and speed of the liquid flowing in and out through the cylinder barrel 100 according to a preset value. In the absence of an additional drug container 420, the process of mixing a drug solution in the infusion bag 400 is the simplest but most basic, and for the additional drug solution, such a process is simply repeated.

[0108] Reference Figure 7, the second inflow passage 204 connected to the fourth tube 340 and the outflow passage 206 connected to the second tube 320 of the three-way valve 200 are in an open state. Therefore, the liquid medicine in the medicine container 410 can flow to the inflow tube 150 of the cylinder barrel 100, and the flow of the infusion through the third tube 330 is blocked. In this state, the control unit of the cylinder pump 500 controls the cylinder driving unit 520 so that the liquid medicine in the medicine container 410 connected to the fourth tube 340 is sucked in a preset amount and flows out to the infusion bag 400 connected to the first tube 310.

[0109] In other words, in the past, professional pharmacists used syringes to extract liquid medicine from medicine containers (ampoules, etc.) and then injected it into the infusion bag 400 to prepare injections. In the present invention, the cylinder pump 500 performs both suction and discharge actions at the same time, just like automatically executing previous syringe operations, reducing the intervention of operators, greatly reducing the risk of handling toxic liquid medicines, and automatically executing accurate measurements related to the prescription and preparation of drugs such as anticancer agents, thereby eliminating the worry of mistakes during preparation.

[0110] In addition, the injection preparation kit 10 of the present invention performs all preparation processes while maintaining a closed system, so the conventional operation of inserting and removing the injection needle is eliminated, reducing the risk of contamination of the infusion bag 400. Here, in order to ensure the closedness of the injection preparation kit 10, it is recommended to use a needleless valve that automatically switches to a locked state when separated at the connection parts of various tubes.

[0111] As described above, the process of preparing an injection according to a prescription using the injection preparation kit 10 and the cylinder pump 500 according to the present invention, and the adapter 300 having an air inflow function, etc., is organized and described as follows. Here, in order to explain the injection preparation process, the cylinder pump 500 is omitted in the referenced figure, which is for the convenience of explanation, and it should be understood that the cylinder pump 500 is used as a matter of course in the operation of the cylinder barrel 100. In addition, the injection preparation process is performed in a sterile facility.

[0112] First, prepare Figure 7 The injection preparation kit 10 shown has an infusion bag 400 connected to the first tube 310 and the third tube 330, and a medicine container 410 connected to the fourth tube 340. Of course, the infusion and medicine used are in accordance with the doctor's prescription. In addition, the cylinder barrel 100 of the injection preparation kit 10 that has been sterilized and packaged is combined with the barrel mounting groove 512 of the cylinder pump 500. Thus, a pair of pistons 140, 142 disposed inside the cylinder barrel 100 can be independently driven by the cylinder drive unit 520 of the cylinder pump 500.

[0113] After the injection dispensing kit 10 is installed, the manufacturer (licensed pharmacist) confirms the dosage of the dispensing liquid indicated in the prescription and inputs the dosage of the liquid to be introduced into the injection liquid bag 400 to the control unit of the cylinder pump 500. In this case, the second inflow channel 204 connected to the fourth tube 340 and the outflow channel 206 connected to the second tube 320 should be opened by operating the three-way valve 200.

[0114] When all these preparations are completed, the cylinder pump 500 is driven to introduce the drug solution in the drug container 410 into the infusion bag 400 according to the set amount. When the drug solution flows to the set amount, the cylinder pump 500 stops operating.

[0115] The above process is the basis for preparing injections. In addition, a certain amount of the drug solution may remain in the first tube 310 and the second tube 320, instead of being introduced into the infusion bag. In order to inject all of these remaining drug solutions into the infusion bag 400, a process of circulating the infusion in the infusion bag 400 is performed. That is, the three-way valve 200 is operated to open the first inflow channel 202 connected to the third tube 330 and the outflow channel 206 connected to the second tube 320 to form a circulating flow path for the infusion, and then the cylinder pump 500 is operated to circulate the infusion in the infusion bag 400 through the cylinder barrel 100, so that all the drug solution remaining in the tube is introduced into the infusion bag 400.

[0116] The above description is about the method of first sucking and discharging the liquid medicine in the medicine container 410. Before that, the filling step of removing the air in the first tube 310, the second tube 320, and the third tube 330 may be included. The filling step is similar to the process of circulating the infusion in the infusion bag 400. Figure 8 The first inflow passage 202 connected to the third tube 330 and the outflow passage 206 connected to the second tube 320 of the three-way valve 200 are in an open state, and the infusion in the infusion bag 400 circulates through the cylinder barrel 100, thereby removing the air in the first to third tubes 330.

[0117] Furthermore, although the above description is based on mixing one type of drug solution, it is of course possible to mix two or more drug solutions in one infusion bag 400 .

[0118] For example, the drug container 410 from which the drug solution has been extracted is replaced with another additional drug container 420, and then the prescription dosage related to the additional drug container 420 is input, and the drug solution in the additional drug container 420 can be introduced into the infusion bag 400 according to the set amount. These processes can be repeated according to the type of prescribed drug solution.

[0119] However, the process of repeatedly coupling and decoupling multiple drug containers 410 with respect to one ampoule adapter 300 may be undesirable in terms of contamination. Fig. 9 As shown, by constructing the injection preparation kit 10 of the present invention, the extraction process can be performed sequentially on the two drug containers 410 and 420 without a replacement process.

[0120] In other words, the first inflow path and the outflow path of at least one additional three-way valve 210 are connected to any one of the second pipe 320, the third pipe 330, and the fourth pipe 340 ( Fig. 9 4 and 400, and the additional medicine container 420 is connected to the second inflow channel of the additional three-way valve 210 to prepare a completed injection preparation kit 10. After that, after the extraction process of the medicine container 410 is completed, while the outflow channel 206 of the medicine container 410 is closed, the outflow channel of the additional medicine container 420 is opened, and the liquid in the additional medicine container 420 is introduced into the infusion bag 400 according to the set amount by driving the cylinder pump 500, thereby completing a series of injection preparation processes.

[0121] In addition, if Fig.10 As described in the embodiment of the present invention, an empty infusion bag 402 can also be used to prepare an injection. In other words, an empty infusion bag 402 is connected to the first tube 310 and the third tube 330, and the first inflow channel and the outflow channel of at least one additional three-way valve 210 are connected to any one of the second tube 320, the third tube 330, and the fourth tube 340, and the infusion bag 400 is connected to the second inflow channel of any one of the additional three-way valves 210 to form the injection preparation kit 10. The drug container 410 is connected to the second inflow channel 204 of the three-way valve 200 through the fourth tube 340. Here, the reason why a plurality of additional three-way valves 210 can be provided is that the additional drug container 420 can also be provided at the same time.

[0122] For the injection preparation kit 10 prepared in this way, the infusion of the infusion bag 400 connected to the second inflow channel of the additional three-way valve 210 is introduced into the empty infusion bag 402 according to the set amount, and then while closing the outflow channel of the infusion bag 400, the outflow channel 206 of the three-way valve 200 relative to the drug container 410 is opened, and the injection is completed by introducing the drug solution in the drug container 410 into the empty infusion bag 402 according to the set amount.

[0123] In addition, after the injection preparation using the cylinder pump 500 is completed, the following can be performed: Fig.12 and Fig.13 Finishing steps shown. Fig.12 As a finishing step, the medicine container 410 and the fourth pipe 340 are removed from the cylinder barrel 100, and the second inflow flow path 204 of the three-way valve 200 connected to the fourth pipe 340 is closed. Fig.13 In the finishing step, the medicine container 410 , the fourth tube 340 , and the second tube 320 are removed relative to the cylinder barrel 100 , and the third tube 330 may also be connected to the inflow tube 150 .

[0124] The ends of various tubes must be sterilized and sealed to ensure that the infusion bag 400 will not be contaminated before being used on a patient. Therefore, the infusion bag 400 prepared in a sterile environment undergoes a finishing step, and continues to maintain a closed system state with the cylinder barrel 100 as the center, thereby solving the problem of contamination and infection caused thereby. Before the infusion bag 400 is injected into a patient, the cylinder barrel 100 is installed on the cylinder pump 500, and the tube connected to the outflow tube 152 is connected to the patient's catheter. After the amount of the prescription is input into the control unit of the cylinder pump 500, the cylinder pump 500 is driven to start the injection.

[0125] on the other hand, Fig.14 The embodiment of a modified injection preparation kit 10 according to the present invention is shown. This embodiment assumes that the drug such as an anticancer agent is provided in a powdered (powdered) form. The powdered drug only needs to be dissolved and diluted with an infusion solution before intravenous injection, and the dilution ratio of the powdered drug is also recorded in the prescription. In this case, the present invention can also use a cylinder pump 500 to mix a precise amount of diluent. For this purpose, Fig.14 An injection preparation kit 10 is shown in FIG.

[0126] The cylinder pump 500 is for liquid (medical solution) and cannot suck in or discharge powder medicine. Therefore, it is applicable to the injection preparation kit 10 for powder medicine. The powder medicine container 430 is installed in the first tube 310 connected to the outflow tube 152 of the cylinder barrel 100, and the diluent bag 404 is connected to the second tube 320 connected to the inflow tube 150 of the cylinder barrel 100. This injection preparation kit 10 for powder medicine sucks the diluent in the diluent bag 404 according to the set amount by driving the cylinder pump 500 and introduces it into the powder medicine container 430. The powder medicine container 430 added with the diluent can be used after being fully dissolved by properly shaking.

[0127] Here, the diluent bag 404 is used to mean a container containing a diluent. Of course, the infusion bag 400 can be used for the infusion, but the diluent may be different depending on the properties of the powder medicine, so it should be noted that different terms are used.

[0128] In addition, it should be noted that the dissolved powder medicine can be treated in the same manner as the general liquid medicine mentioned above, so the powder medicine container 430 after the dissolution process is completed can be handled by Figures 7 to 13The drug container 410 or the additional drug container 420 described above is used in the same manner and is mixed with the infusion bag 400 or the empty infusion bag 402 to prepare the injection.

[0129] The above description is only an example of the technical idea of ​​the present invention. Anyone with general knowledge in the technical field to which the present invention belongs can make various modifications and variations without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of ​​the present invention, but are used for explanation, and the scope of the technical idea of ​​the present invention is not limited by these embodiments.

Claims

1. An injection preparation kit, characterized in that: include: A cylinder barrel, into which external fluid flows and is discharged by a change in cylinder volume caused by a pair of pistons disposed inside being relatively fixed and rotated; a first pipe connected to an outflow pipe of the cylinder barrel; A three-way valve selectively connects any one of the two inflow paths to the outflow path; a second pipe connecting an outflow passage of the three-way valve to an inflow pipe of the cylinder barrel; a third pipe connected to the first inflow flow path of the three-way valve; as well as a fourth pipe connected to a second inflow flow path of the three-way valve; Also includes at least one additional three-way valve, The first inflow channel and the outflow channel of the additional three-way valve are connected to any one of the second to fourth pipes; An infusion bag is connected to the second inflow channel of the additional three-way valve, an empty infusion bag is connected to the first tube and the third tube, and a drug container is connected to the fourth tube.

2. The injection preparation kit according to claim 1, characterized in that: The fourth tube and the medicine container are connected via an adapter with an air inflow function.

3. The injection preparation kit according to claim 1, characterized in that: The cylinder barrel has an upper rotating body and a lower rotating body that can rotate freely with each other. An annular cylinder space is formed between the upper rotating body and the lower rotating body. In the pair of pistons, the first piston is rotatable along the cylinder space by being coupled to the upper rotating body, and the second piston is rotatable along the cylinder space by being coupled to the lower rotating body.

4. An injection preparation system, characterized in that: include: The injection preparation kit according to any one of claims 1 to 3; as well as A cylinder pump is provided, which is equipped with a cylinder barrel of an injection preparation kit and independently drives a pair of pistons arranged inside the cylinder barrel.

5. The injection preparation system according to claim 4, characterized in that: The cylinder pump includes a cylinder driving unit that independently drives a pair of pistons provided in a cylinder tube and a control unit that controls the cylinder driving unit, and the control unit controls the amount and speed of liquid flowing in and out of the cylinder tube according to preset values.

6. The injection preparation system according to claim 5, characterized in that: The control unit controls the cylinder driving unit so that a predetermined amount of drug solution in the drug container connected to the fourth tube flows in and out to the infusion bag connected to the first tube.

7. The injection preparation system according to claim 6, characterized in that: The second inflow channel connected to the fourth pipe and the outflow channel connected to the second pipe of the three-way valve are in an open state.

8. The injection preparation system according to claim 5, characterized in that: The cylinder driving unit includes a first driving unit for driving an upper rotating body of the cylinder tube and a second driving unit for driving a lower rotating body. A double-axis structure is formed in which the second driving shaft of the second driving part enters into the first driving shaft of the first driving part.

9. The injection preparation system according to claim 8, characterized in that: The first driving part and the second driving part are worm gear transmission structures respectively.

10. A method for preparing an injection, characterized in that: include: Step 1, preparing the injection preparation kit according to claim 1, connecting an infusion bag to the first tube and the third tube, and connecting a drug container to the fourth tube; In the second step, the cylinder barrel of the injection preparation kit is installed in a cylinder pump, and the cylinder pump independently drives a pair of pistons arranged inside the cylinder barrel; Step 3: inputting the amount of drug solution in the drug container to be introduced into the infusion bag to the cylinder pump; Step 4, opening the second inflow channel connected to the fourth pipe and the outflow channel connected to the second pipe with respect to the three-way valve; In step 5, the cylinder pump is driven to introduce the drug solution in the drug container into the infusion bag according to the set amount.

11. The method for preparing an injection according to claim 10, characterized in that: After step 5, In order to form a circulating flow path for infusion by operating the three-way valve, the first inflow path connected to the third tube and the outflow path connected to the second tube are opened, and the cylinder pump is operated so that the infusion in the infusion bag circulates through the cylinder barrel, thereby introducing all the remaining liquid medicine in the tube into the infusion bag.

12. The method for preparing an injection according to claim 10, characterized in that: A liquid filling step for removing air from the first to third tubes is included between the third step and the fourth step.

13. The method for preparing an injection according to claim 12, characterized in that: In the filling step, the first inflow channel connected to the third tube and the outflow channel connected to the second tube are opened with respect to the three-way valve, The infusion in the infusion bag is circulated through the cylinder tube, thereby removing the air in the first to third tubes.

14. The method for preparing an injection according to claim 10, characterized in that: The step of replacing the drug container with another additional drug container and driving the cylinder pump to introduce the drug solution in the additional drug container into the infusion bag in a set amount is performed.

15. The method for preparing an injection according to claim 10, characterized in that: The first step includes step 1-1, connecting the first inflow channel and the outflow channel of at least one additional three-way valve to any one of the second to fourth tubes, and connecting the additional drug container to the second inflow channel of the additional three-way valve, After the fifth step, an additional mixing step is included, in which the outflow passage of the medicine container is closed, the outflow passage of the additional medicine container is opened, and the medicine solution in the additional medicine container is introduced into the infusion bag according to a set amount by driving the cylinder pump.

16. The method for preparing an injection according to claim 10, characterized in that: The first step includes step 1-1, connecting an empty infusion bag to the first tube and the third tube, connecting the first inflow channel and the outflow channel of at least one additional three-way valve to any one of the second to fourth tubes, connecting the infusion bag to the second inflow channel of any one of the additional three-way valves, Steps 3 to 5 are to introduce the infusion of the infusion bag connected to the second inflow channel of the additional three-way valve into the empty infusion bag according to the set amount, and then close the outflow channel of the infusion bag while opening the outflow channel of the medicine container, thereby introducing the drug solution in the medicine container into the empty infusion bag according to the set amount.

17. The method for preparing an injection according to claim 10, characterized in that: After step 5, a finishing step is added to remove the medicine container and the fourth tube from the cylinder tube and close the second inflow passage of the three-way valve. Alternatively, the medicine container and the fourth tube and the second tube are removed, and the third tube is connected to the end of the inflow tube.

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