A multifunctional 14 C measuring device and Helicobacter pylori detector

Abstract

The present invention relates to the technical field of medical instruments, and specifically discloses a multifunctional <supgt;14< / supgt;C measuring device that uses photomultiplier tubes to detect consumables to improve detection efficiency and accuracy and is compatible with supporting the detection of cassette or / and liquid scintillation and solid scintillation consumables. The device includes a detection main body with an opposed area inside, and a drawer slidably inserted on the detection main body. Two photomultiplier tubes are relatively arranged on both sides of the opposed area inside the detection main body. A receiving groove for placing consumables to be detected is provided inside the drawer, and two through holes are provided on both side edges of the drawer and communicated with the receiving groove. A highly transparent plastic scintillator is detachably embedded in each through hole; the receiving groove is a gas collecting card slot extending along the length direction of the drawer and penetrating the top surface of the drawer; or the receiving groove is a round hole slot penetrating the top surface of the drawer and extending along the height direction of the drawer and communicating with the through holes; or the receiving groove includes a card embedding part and a bottle body embedding part. A Helicobacter pylori detector including the device is also disclosed.

Description

Technical Field

[0001] The present invention relates to the technical field of medical instruments, and in particular to a multifunctional 14 C measuring device and Helicobacter pylori detector. Background Art

[0002] Helicobacter pylori is closely related to the occurrence of chronic gastritis, peptic ulcer and gastric cancer. It is an important indicator for the diagnosis of digestive diseases and has been listed as a class I carcinogen. The detection of Helicobacter pylori is based on the fact that Helicobacter pylori can secrete urease during its survival in the patient's stomach. 14 C] capsule, which allows the urease produced by Helicobacter pylori in the stomach to catalyze the rapid hydrolysis of urea into NH4 + and H 14 CO3 - , which can be absorbed from the stomach into the blood and passed through the lungs 14 CO2 is exhaled, so by collecting a breath sample and measuring it on an instrument 14 CO2 can determine whether there is Helicobacter pylori infection.

[0003] At present, the detection methods for Helicobacter pylori are divided into invasive detection and non-invasive detection. Among them, the urea breath test in non-invasive detection is divided into card type, liquid scintillation type and solid scintillation type according to the different breath collection and measurement devices. The card type uses a card-shaped form as a breath collection device for Helicobacter pylori detection. A strong alkaline substance is attached to the detection window of the card to absorb the exhaled urea containing 14 C of CO2 gas, and detect the exhaled gas; 14 C decay process emits β rays, which are currently mainly detected by Geiger-Muller tube (GM tube) using ionization counting method. Liquid scintillation is the use of glass bottles as breath collection devices for Helicobacter pylori detection. The bottle contains alkaline substances and organic solvents such as methanol. The subject blows the breath containing liquid through the blowing tube inserted into the bottle solution. 14 The CO2 gas of C is blown into the bottle and absorbed, and then scintillation liquid is added into the bottle. The radioactivity of the sample is measured by the principle of liquid scintillation counting through a photomultiplier tube. The solid flash type uses a plastic bottle as a breath collection device for Helicobacter pylori detection. The bottle body has an overlapping structure of scintillation plate and absorption plate. The scintillation plate is pre-coated with scintillation liquid. The subject also blows the scintillation liquid containing the scintillation liquid into the bottle through the air tube. 14 C of CO2 gas is blown into the plastic bottle and absorbed. Its detection principle is consistent with the liquid scintillation method, that is, the liquid scintillation counting method is used.

[0004] Among the above three detection methods, the amplitude and 14There is a problem of lack of connection between C abundance and the abundance of the scintillation medium. Therefore, when there is radiation contamination in the card-type consumables, it is impossible to identify the interference signal and the useful signal from the output signal, which easily leads to false positives, false negatives and other problems; in addition, the detection efficiency of the GM tube is usually only about 8%, which will lead to relatively low detection sensitivity and detection accuracy. The detection efficiency and accuracy of liquid scintillation consumables can be greatly improved by using photomultiplier tubes, but there are disadvantages such as troublesome configuration of scintillation liquid, low work efficiency and high overall cost. The detection efficiency and accuracy of solid flash consumables are improved by using photomultiplier tubes compared with card-type devices, but solid flash consumables cannot be mass-produced automatically, and their solid flash consumables have the defect of unstable quality. At present, from the perspective of actual market applications, different detection methods and use environments require different detection consumables. A single detection device can only detect one sample of the card-type, liquid scintillation or solid flash type, and there are certain defects. It is difficult to meet the accuracy and cost requirements of different detection methods for the same detection device. Summary of the invention

[0005] Based on this, it is necessary to provide a multifunctional device that can support the detection of cassette and / or liquid scintillation and solid scintillation consumables to address the above shortcomings. 14 C measuring device and Helicobacter pylori detector, the multifunctional 14 The C measuring device uses photomultiplier tubes to detect consumables, which improves detection efficiency and accuracy. It is also compatible with the detection of cassette and / or liquid scintillator consumables and solid scintillator consumables, improving the versatility of the equipment.

[0006] A multifunctional 14 C measuring device, comprising a detection body with an illumination area inside, a drawer inserted in the detection body and capable of being pushed and pulled into or out of the illumination area, two photomultiplier tubes being arranged opposite to each other on both sides of the illumination area inside the detection body, a receiving groove for placing consumables to be detected being provided in the drawer, and two opposite sides of the drawer are respectively provided with a through hole communicating with the receiving groove, and a high-transparency plastic scintillator corresponding to the photomultiplier tube when the drawer is pushed into the illumination area is detachably embedded in each through hole;

[0007] The receiving slot is a gas collecting card slot extending along the length direction of the drawer and penetrating the top surface of the drawer, and the gas collecting card slot is used to insert the gas collecting card; or

[0008] The receiving groove is a circular hole groove that passes through the top surface of the drawer and extends along the height direction of the drawer, the circular hole groove is connected with the through hole, and the circular hole groove is used to insert a liquid scintillation bottle or a solid scintillation bottle; or

[0009] The receiving groove includes a card embedding portion extending along the length direction of the drawer and penetrating the top surface of the drawer, and a bottle body embedding portion arranged between the two ends of the card embedding portion, penetrating the top surface of the drawer and connected to the through hole. The receiving groove is used to insert a gas collection card or a liquid scintillation bottle or a solid scintillation bottle.

[0010] In one embodiment, the detection body includes a shell with the corresponding illumination area inside, two sleeves arranged on two sides of the shell and connected to the corresponding illumination area respectively, and a darkroom box fixed at one end of the shell and connected to the corresponding illumination area. The drawer is located at the other end of the shell and can be pushed and pulled to enter or leave the corresponding illumination area, and each of the sleeves is provided with a photomultiplier tube.

[0011] In one of the embodiments, a light guide is provided on the inner surface of the through hole outside the high-transparency plastic scintillator.

[0012] In one of the embodiments, the highly transparent plastic scintillator and the light guide are integrally formed and inserted into the through hole.

[0013] In one of the embodiments, a limiting abutment portion for limiting the maximum insertion depth of the drawer is provided in the reflection area.

[0014] In one embodiment, a handle is provided on the drawer at one end away from the darkroom box.

[0015] In one embodiment, the shell is a hollow sleeve with a stepped limiter inside, two sleeves respectively penetrate the annular side wall of the hollow sleeve and cooperate with the stepped limiter, and the darkroom box and the drawer are respectively located on both sides of the hollow sleeve.

[0016] In one of the embodiments, the top surface of the drawer is recessed to form a avoidance area connected to the receiving groove.

[0017] The invention also discloses a method comprising the multifunctional 14 C measuring device for Helicobacter pylori detection.

[0018] The multifunctional method of implementing the present invention 14 The C measuring device and Helicobacter pylori detector use photomultiplier tubes to detect consumables, which greatly improves detection efficiency and accuracy, solves the problems of false positives and false negatives caused by contamination of consumables by radiation when using GM tubes for detection, and greatly improves detection accuracy and efficiency; the device is compatible with the detection support of cassette, liquid scintillation and solid scintillation consumables, improves the flexibility and scope of use of the device, has better versatility, and reduces the cost of testing samples in different sampling forms. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 In one embodiment of the present invention, a multifunctional 14 C is a schematic diagram of the cross-sectional structure of the measuring device;

[0020] Figure 2 In another embodiment of the present invention, a multifunctional 14C is a schematic diagram of the cross-sectional structure of the measuring device;

[0021] Figure 3 In one embodiment of the present invention, a multifunctional 14 C. Schematic diagram of the structure of the measuring device in use;

[0022] Figure 4 In one embodiment of the present invention, a multifunctional 14 C. Structural schematic diagram of the measuring device in another use state;

[0023] Figure 5 In one embodiment of the present invention, a multifunctional 14 C is a schematic diagram of the structure of the measuring device in another usage state. DETAILED DESCRIPTION

[0024] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0025] The present invention aims at the problem that the detection result accuracy of the traditional GM tube detection gas collection card is insufficient, and the detection cost is high because the gas collection card is different from the solid flash and liquid flash consumables detection based on the different working principles. When detecting different forms of consumables, different detection equipment needs to be used respectively. The present invention provides a multifunctional device that is compatible with card-type, solid flash and liquid flash consumables while ensuring the high accuracy of the detection result of card-type consumables. 14 C measuring device improves the versatility of the equipment for different forms of consumables and the reliability of the test results.

[0026] For details, please refer to Figure 1 , the multifunctional 14The C measuring device comprises a detection body with an internally arranged facing area, a drawer 400 inserted on the detection body and capable of being pushed and pulled into or out of the facing area, two photomultiplier tubes 500 are disposed oppositely at both sides of the facing area in the detection body, a receiving groove 600 for placing consumables to be detected is provided in the drawer 400, and two opposite sides of the drawer 400 are respectively provided with a through hole 410 connected with the receiving groove 600, and a highly transparent plastic scintillator 700 corresponding to the photomultiplier tube 500 when the drawer 400 is pushed into the facing area is detachably embedded in each through hole 410. In this embodiment, the detection body comprises a housing 100 with an internally arranged facing area, two sleeves 200 disposed oppositely at both sides of the housing 100 and respectively connected with the facing area, and a darkroom box 300 fixed at one end of the housing 100 and connected with the facing area, the drawer 400 is located at the other end of the housing 100 and capable of being pushed and pulled into or out of the facing area, and one of the photomultiplier tubes 500 is respectively disposed in each sleeve 200. In this embodiment, the housing 100 is a hollow sleeve with a stepped stopper 110 inside, and the two sleeves 200 respectively penetrate the annular side wall of the hollow sleeve and cooperate with the stepped stopper 110, and the darkroom box 300 and the drawer 400 are respectively located on both sides of the hollow sleeve. After the consumables to be tested are loaded into the receiving groove 600 and the drawer 400 is pushed into the shooting area, the through holes 410 on both sides of the drawer 400 correspond to the photomultiplier tubes 500 on both sides of the housing 100, so that the two photomultiplier tubes 500 can detect the parts of the consumables to be tested corresponding to the through holes 410 after being powered on and shooting.

[0027] In this embodiment, the multifunctional 14 The C measuring device can detect only card-type consumables, only solid flash consumables or liquid flash consumables, or can be compatible with the detection of card-type consumables, solid flash consumables and liquid flash consumables. That is to say, the receiving groove 600 includes three structures, namely, the receiving groove 600 is a gas collecting card groove extending along the length direction of the drawer 400 and penetrating the top surface of the drawer 400, and the gas collecting card groove is used to insert the gas collecting card; or the receiving groove 600 is a circular hole groove penetrating the top surface of the drawer 400 and extending along the height direction of the drawer 400, the circular hole groove is connected with the through hole 410, and the circular hole groove is used to insert the liquid scintillation bottle or the solid flash bottle; or the receiving groove 600 includes a card embedding portion 610 extending along the length direction of the drawer 400 and penetrating the top surface of the drawer 400, and a bottle body embedding portion 620 arranged between the two ends of the card embedding portion 610 and penetrating the top surface of the drawer 400 and communicating with the through hole 410, the receiving groove 610 is used to insert the gas collecting card or the liquid scintillation bottle or the solid flash bottle, that is, when the receiving groove 600 includes the card embedding portion 610 and the bottle body embedding portion 620, it can be used for multi-function 14 The consumables tested by the C measuring device include gas collection cards, solid scintillation bottles and liquid scintillation bottles, that is, card-type and liquid / solid scintillation samples can all be placed in one device for testing. Figure 3-5It shows the situation that when the receiving slot 600 includes a card embedding portion 610 and a bottle body embedding portion 620, a gas collecting card 10, a liquid flash bottle 20 and a solid flash bottle 30 are respectively loaded. In addition, in this embodiment, the top surface of the drawer 400 is recessed to form a avoidance area 420 connected to the receiving slot 600. The avoidance area 420 provides a probe position for fingers or other gripping tools when the gas collecting card is inserted into the receiving slot 600. That is to say, by setting the avoidance area 420, when the gas collecting card is inserted into the receiving slot 600, a part of the gas collecting card is exposed outside the receiving slot 600 and is located in the avoidance area 420, so as to reduce the difficulty for the operator to remove the gas collecting card after detection.

[0028] In one embodiment, the inner surface of the through hole 410 is provided with a light guide 800 outside the highly transparent plastic scintillator 700. In this embodiment, the light guide 800 is a tubular structure, also known as a light pipe, and its inner surface is coated with a reflective coating, which is mainly used to gather the fluorescence emitted by the highly transparent plastic scintillator 700, or gather the fluorescence emitted by the scintillator substance in the liquid scintillator bottle or the solid scintillator bottle, so that the photomultiplier tube 500 can detect more effective photons, thereby improving the sensitivity of the photomultiplier tube 500 and the reliability of the detection result.

[0029] In this embodiment, the light guide 800 is provided to cooperate with the detachable high-transparency plastic scintillator 700, mainly to adapt to the detection of the gas collection card. Figure 1 and Figure 3 When the gas collection card is inserted into the receiving slot 600 for testing, a strong alkaline absorbent is coated on the gas collection card to absorb the carbon dioxide gas exhaled by the subject. If the subject is Hp(+) (i.e. Helicobacter pylori positive), the exhaled gas contains 14 CO2, 14 In the process of C decay, β rays are released. In this embodiment, a photomultiplier tube 500 is used for detection, and a layer of highly transparent plastic scintillator 700 is installed between the photomultiplier tube 500 and the gas collection card. 14 When the beta rays generated by the C decay process pass through the highly transparent plastic scintillator 700, they will cause the ionization and excitation of the scintillator atoms. The excited electrons will stimulate visible light (fluorescence), which will then be detected by the photomultiplier tube 500, thereby realizing the detection of the gas collecting card through the signal change of the photomultiplier tube 500. In this way, the problem of insufficient measurement accuracy caused by the low detection efficiency of the Geiger-Mueller counter (GM tube) when directly detecting beta rays is overcome. When the highly transparent plastic scintillator 700 is combined with the photomultiplier tube 500, it is also possible for the card type, liquid scintillator type and solid scintillator type to be measured in the same device. 14 C laid the foundation.

[0030] Please combine Figure 2 , Figure 4 as well as Figure 5 When testing the solid scintillation bottle 30 or the liquid scintillation bottle 20, the bottle body embedding portion 620 of the circular hole groove or the receiving groove 600 is a position for placing the liquid scintillation or solid scintillation sample. The liquid scintillation bottle 20 contains organic solvents such as gas agent and scintillation liquid; the solid scintillation bottle 30 is a plastic bottle structure, and the internal scintillation sheet and absorption sheet present an overlapping structure, wherein the scintillation sheet is coated with scintillation liquid material. When the subject blows into the liquid scintillation bottle 20 or the solid scintillation bottle 30, the gas will be collected in the bottle body due to the presence of CO2 absorbent (usually a strong alkaline substance) in the bottle. If the subject is in the Hp(+) state (that is, Helicobacter pylori positive), the exhaled gas contains 14 CO2, 14 During the C decay process, β rays are released, which excite the scintillator material to emit fluorescence, which is then detected by the photomultiplier tube 500.

[0031] In addition, in this embodiment, the highly transparent plastic scintillator 700 is designed to be a detachable structure. When the measuring device is adaptable to the detection of card-type, solid flash-type and liquid flash-type consumables, when detecting the gas collecting card, the highly transparent plastic scintillator 700 can be embedded in the through hole 410 to cooperate with the photomultiplier tube 500 to realize the detection of the gas collecting card; when it is necessary to detect the liquid scintillation bottle or the solid flash bottle, the highly transparent plastic scintillator 700 can be removed from the through hole 410 so that the liquid scintillation bottle or the solid flash bottle can be inserted into the bottle body embedding part 620 of the circular hole groove or the receiving groove 600. Since the highly transparent plastic scintillator 700 is highly transparent and can transmit photons to the maximum extent, even if the highly transparent plastic scintillator 700 is installed in the through hole 410 during the detection of the liquid scintillation bottle or the solid flash bottle, it will not affect the detection result of the liquid scintillation bottle or the solid flash bottle. In addition, when measuring liquid scintillator or solid scintillator consumables, the highly transparent plastic scintillator 700 has an enhancement effect on weak optical signals, which can further improve the detection efficiency and accuracy of liquid scintillator and solid scintillator consumables.

[0032] In one embodiment, the highly transparent plastic scintillator 700 and the light guide 800 are integrally formed and inserted into the through hole 410. In this way, while improving the connection stability between the two, it is convenient to install and maintain the highly transparent plastic scintillator 700 and the light guide 800, so that they are compatible with online products. When testing samples of different forms (card type, solid flash type or liquid flash type), the highly transparent plastic scintillator 700 and the light guide 800 integral structure can be removed from the through hole 410 according to the detection needs, or the insertion depth of the highly transparent plastic scintillator 700 and the light guide 800 integral structure in the through hole 410 can be adjusted according to the thickness of the gas collection card or the diameter of the liquid scintillator bottle and the liquid scintillator bottle, so that the highly transparent plastic scintillator 700 can abut against the consumables to be detected and position the consumables to be detected.

[0033] Please combine Figure 1 and Figure 3In one embodiment, a limiting abutment 120 for limiting the maximum insertion depth of the drawer 400 is provided in the corresponding region to ensure that when the end of the drawer 400 adjacent to the darkroom box 300 abuts against the limiting abutment 120, the two through holes 410 on the drawer 400 are directly opposite to the two photomultiplier tubes 500, so that the fluorescence generated by the consumables to be detected or the fluorescence excited by the high-transparent plastic scintillator 700 can be detected by the photomultiplier tubes 500 as much as possible, so as to improve the sensitivity and reliability of the detection. In addition, in this embodiment, a handle 430 is provided on the drawer 400 at the end away from the darkroom box 300, and the handle 430 is used to provide a gripping portion when the drawer 400 is pushed into the corresponding region or pulled out from the corresponding region.

[0034] In addition, the present invention also discloses a multifunctional 14 The Helicobacter pylori detector of the C measuring device includes a shell, a main controller housed in the shell and electrically connected to the photomultiplier tube 500, a display screen and a control switch installed on the outer surface of the shell and electrically connected to the main controller, and a power supply device housed in the shell and providing power to the main controller. Of course, the Helicobacter pylori detector may also include a communication module electrically connected to the main controller, which is used to provide a communication connection part between the main controller and an external smart device, so as to realize the sharing of detection information and remote control of the measuring device over a long distance.

[0035] The multifunctional method of implementing the present invention 14 C measuring device uses photomultiplier tube 500 to detect consumables, which greatly improves detection efficiency and accuracy, solves the false positive and false negative problems caused by contamination of consumables by radiation when using GM tube detection, and greatly improves detection accuracy and efficiency; the device is compatible with the detection support of card-type, liquid scintillation and solid scintillation consumables, improves the flexibility and scope of use of the device, has better versatility, and reduces the cost of testing samples in different sampling forms.

[0036] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0037] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A multifunctional 14 C measuring device, characterized in that The invention comprises a detection body with an illumination area provided therein, and a drawer inserted in the detection body and capable of being pushed and pulled into or out of the illumination area, wherein two photomultiplier tubes are arranged opposite to each other on both sides of the illumination area inside the detection body, and a receiving groove for placing consumables to be detected is provided in the drawer, and two opposite sides of the drawer are respectively provided with a through hole connected to the receiving groove, and a highly transparent plastic scintillator corresponding to the photomultiplier tube when the drawer is pushed into the illumination area is detachably embedded in each through hole; The receiving groove includes a card embedding portion extending along the length direction of the drawer and penetrating the top surface of the drawer, and a bottle body embedding portion arranged between the two ends of the card embedding portion, penetrating the top surface of the drawer and connected to the through hole. The receiving groove is used to insert a gas collection card or a liquid scintillation bottle or a solid scintillation bottle.

2. The multifunctional device according to claim 1 14 C measuring device, characterized in that The detection body includes a shell body with the corresponding illumination area inside, two sleeves arranged on two sides of the shell body and connected to the corresponding illumination area respectively, and a darkroom box fixed at one end of the shell body and connected to the corresponding illumination area. The drawer is located at the other end of the shell body and can be pushed and pulled into or out of the corresponding illumination area. A photomultiplier tube is respectively arranged in each of the sleeves.

3. The multifunctional device according to claim 2 14 C measuring device, characterized in that The inner surface of the through hole is provided with a light guide outside the high-transparency plastic scintillator.

4. The multifunctional device according to any one of claims 3 14 C measuring device, characterized in that The high-transparency plastic scintillator and the light guide are integrally formed and inserted into the through hole.

5. The multifunctional device according to claim 4 14 C measuring device, characterized in that The opposing area is provided with a limiting abutment portion for limiting the maximum insertion depth of the drawer.

6. The multifunctional device according to claim 5 14 C measuring device, characterized in that The drawer is provided with a handle at one end away from the darkroom box.

7. The multifunctional device according to claim 6 14 C measuring device, characterized in that The shell is a hollow sleeve with a stepped limiter inside, the two sleeves respectively penetrate the annular side wall of the hollow sleeve and cooperate with the stepped limiter, and the darkroom box and the drawer are respectively located on both sides of the hollow sleeve.

8. The multifunctional device according to claim 7 14 C measuring device, characterized in that The top surface of the drawer is recessed to form an avoidance area communicated with the receiving groove.

9. A Helicobacter pylori detector, characterized in that: The multifunctional device comprising any one of claims 1 to 8 14 C measuring device.

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