A chain composition preparation device and a preparation method

Abstract

The application discloses a chain composition preparation device and a preparation method, which comprise a perfusion part, a push injection part, a first connecting pipe, a second connecting pipe, a distribution valve and a transfusion pipe; the perfusion part is communicated with the push injection part through the first connecting pipe, the distribution valve is communicated with the first connecting pipe through the second connecting pipe, the transfusion pipe is connected to the distribution valve, and the distribution valve is also used for being connected with external gas supply parts and liquid supply parts; the perfusion part is used for sucking gas in the gas supply parts and liquid in the liquid supply parts into the second connecting pipe in sequence to form a gas-liquid alternating agent type medicine; and the push injection part is used for pushing the gas-liquid alternating agent type medicine to pass through the distribution valve and enter the transfusion pipe. Therefore, the chain composition preparation device can realize the integration of medicine configuration and medicine injection, thereby improving the convenience of medicine injection and being beneficial to improving the injection efficiency of the medicine.

Description

TECHNICAL FIELD

[0001] The present application relates to a chain composition preparation device and a preparation method, and belongs to the technical field of medical devices. BACKGROUND

[0002] With the development of medical technology, transcatheter arterial infusion chemotherapy technology has emerged. This technology is an important means of tumor interventional therapy and can be used for radial artery and other parts. This treatment method is to send a microcatheter into the diseased arterial blood vessel through the radial artery, and then inject therapeutic drugs through the microcatheter, so as to achieve the purpose of precise perfusion therapy, while greatly reducing side effects.

[0003] The key to transcatheter arterial infusion therapy technology is to control the perfusion pressure and speed of the drug. If the perfusion pressure or speed is too high, the drug is easy to reflux or the microcatheter pops out of the local artery, and if the pressure or speed is too low, the drug is difficult to reach the inside of the tumor, so the operator needs to repeatedly perform hand contrast to find the appropriate injection pressure and speed. In this way, it is impossible to guarantee the homogeneity of the optimal operation. Local perfusion can improve the local drug concentration, improve the curative effect, and reduce side effects.

[0004] Therefore, a chain composition preparation and injection system is needed to generate a chain composition formed by different media alternately. The structure of the chain composition can refer to the patent application No. 201880021772.X filed by the applicant on March 26, 2018. SUMMARY

[0005] The primary technical problem to be solved by the present application is to provide a chain composition preparation device.

[0006] Another technical problem to be solved by the present application is to provide a chain composition preparation method.

[0007] To achieve the above technical purposes, the present application adopts the following technical solutions:

[0008] A chain composition preparation device, comprising:

[0009] A distribution valve comprising a plurality of distribution ports;

[0010] A perfusion part connected to one of the plurality of distribution ports through a first connecting pipe, for allowing gas or liquid to enter the first connecting pipe from the distribution valve, forming a chain composition of different media alternately;

[0011] A bolus part connected to one of the plurality of distribution ports through the first connecting pipe, for pushing the chain composition located in the first connecting pipe;

[0012] An infusion tube connected to another of the plurality of distribution ports for outputting the chain composition from the distribution valve.

[0013] Wherein preferably, the perfusion part comprises a first plunger and a first connection valve, the first connection valve having at least a first valve port, a second valve port and a third valve port which can be communicated with each other in pairs, the first plunger being installed at the first valve port, and the third valve port being a vent valve port.

[0014] Wherein preferably, the bolus part comprises a second plunger and a second connection valve, the second connection valve having at least a fourth valve port, a fifth valve port and a sixth valve port which can be communicated with each other in pairs, the second plunger being installed at the fourth valve port, the sixth valve port being used for connecting with a saline supply part, and the fifth valve port being communicated with the second valve port through the first connection tube.

[0015] Wherein preferably, a common connection end is rotatably arranged at the center of the distribution valve, a plurality of distribution ports are formed on the outer wall of the distribution valve, and the common connection end can be rotated around the central axis of the distribution valve to communicate with any of the distribution ports.

[0016] The proximal end of the second connection tube is connected with the first connection tube, the distal end of the second connection tube is connected with the common connection port, one of the plurality of distribution ports is connected with the infusion tube, and the remaining distribution ports are used for connecting with different gas supply parts or liquid supply parts.

[0017] Wherein preferably, a pressure sensor is further included, and the pressure sensor is installed on the first connection tube between the fifth valve port and the proximal end of the second connection tube.

[0018] Wherein preferably, the first connection tube and the second connection tube are both Teflon tubes.

[0019] Wherein preferably, the perfusion part further comprises a plunger driving part, the first plunger comprises a first plunger tube and a first plunger rod, the distal end of the first plunger tube is connected with the first valve port, the first plunger rod is movably arranged in the first plunger tube, and the plunger driving part is connected with the first plunger rod to drive the first plunger rod to reciprocate in the first plunger tube.

[0020] Wherein preferably, the perfusion part further comprises a valve driving part, the first connection valve comprises a first valve body and a first valve core, a central hole is formed on the first valve body in the axial direction, and the first valve port, the second valve port and the third valve port are formed on the outer wall of the first valve body in the radial direction and communicated with the central hole;

[0021] The first valve core is provided with a curved channel penetrating the outer wall of the first valve core, the first valve core is rotatably arranged in the center hole, and the first valve core is connected with the valve driving part for driving the first valve core to rotate around the center axis of the first valve body, so that the two ends of the curved channel are respectively communicated with any two of the first valve port, the second valve port and the third valve port.

[0022] A preparation method using the chain composition preparation device.

[0023] The present application has the following technical effects:

[0024] The chain composition preparation device of the technical scheme of the present application first uses the perfusion part to continuously suck the air in the first connecting pipe and the second connecting pipe, so that the physiological saline enters the second connecting pipe to empty the first connecting pipe and the second connecting pipe, until the first connecting pipe and the second connecting pipe are filled with physiological saline; then, by adjusting the distribution valve to be connected with different gas supply parts or liquid supply parts, and by using the perfusion part to alternately suck gas and liquid, the excess physiological saline is discharged, so as to form the gas-liquid alternating dosage form in the second connecting pipe; finally, the bolus part is used to suck the physiological saline, and then the physiological saline is pushed into the first connecting pipe, so as to extrude the alternating dosage form in the second connecting pipe through the distribution valve into the infusion pipe, so as to use the infusion pipe to inject the patient. Therefore, the chain composition preparation device can realize the integration of perfusion and bolus injection, improve the convenience, preparation efficiency and accuracy of preparation, and also reduce the volume and cost of the chain composition preparation device. The chain composition preparation device can realize the integration of perfusion and bolus injection, so that the user can prepare the medicine on site, expand the application range of medicine preparation, realize the medicine administration mode of preparing and sending into the body at the same time, and accurately send to the specific position of the arterial blood vessel or tissue. The perfusion speed and pressure can be accurately controlled. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 A structure schematic view of a chain composition preparation device provided for an embodiment of the present application;

[0026] Figure 2 A split structure schematic view of the first plunger;

[0027] Figure 3 A partial sectional view of the first connecting valve;

[0028] Figure 4 A structure schematic view of the perfusion part;

[0029] Figure 5 A structure schematic view of the distribution valve. DETAILED DESCRIPTION

[0030] The technical content of the present application will be described in detail below in combination with the drawings and specific embodiments.

[0031] <First embodiment>

[0032] Please refer to Figure 1 The chain composition preparation device provided by the embodiment of the present application (in this embodiment, the preparation and injection system of two substances of gas and liquid are taken as an example for description) includes a perfusion part 1, a bolus part 2, a first connecting pipe 3, a second connecting pipe 4, a distribution valve 5, and a transfusion pipe 6.

[0033] The perfusion part 1 is in communication with the bolus part 2 through the first connecting pipe 3, the distribution valve 5 is in communication with the first connecting pipe 3 through the second connecting pipe 4, the transfusion pipe 6 is connected to the distribution valve 5, and the distribution valve 5 is also used to be connected with an external gas supply part (which can also not be connected with the external gas supply part, and is directly opened to air in and out) and a liquid supply part; the perfusion part 1 is used to suck the gas in the gas supply part and the liquid in the liquid supply part into the second connecting pipe 4 in sequence to form a chain composition of alternating different media (in this embodiment, a gas-liquid alternating agent type of medicament is taken as an example for description); and the bolus part 2 is used to push the gas-liquid alternating agent type of medicament through the distribution valve 5 and into the transfusion pipe 6.

[0034] In specific use, first, the perfusion part 1 is used to continuously suck the air in the first connecting pipe 3 and the second connecting pipe 4, so that the physiological saline enters the second connecting pipe 4 to empty the first connecting pipe 3 and the second connecting pipe 4, until the first connecting pipe 3 and the second connecting pipe 4 are filled with the physiological saline; then, the distribution valve 5 is adjusted to be connected with different gas supply parts or liquid supply parts, and the perfusion part 1 is used to alternately suck the gas and the liquid, and then the excess physiological saline is discharged, so that the gas-liquid alternating agent type of medicament is formed in the second connecting pipe 4; finally, the bolus part 2 is used to suck the physiological saline, and then the physiological saline is pushed into the first connecting pipe 3, so that the alternating agent type of medicament in the second connecting pipe 4 is squeezed into the transfusion pipe 6 through the distribution valve 5, to inject the patient by using the transfusion pipe 6. Thus, the chain composition preparation device can realize the integration of medicament perfusion and bolus injection, has high preparation efficiency, convenient operability, and accurate compounding (the amount of different media can be accurately controlled), so that the user can prepare the medicament on site, expand the application range of medicament preparation, realize the medication mode of preparing and sending into the body at the same time, and accurately send to a specific position of an arterial blood vessel or tissue.

[0035] In the above embodiment, specifically, the perfusion part 1 includes a first plunger 11 and a first connecting valve 12. Please refer to Figure 2As shown, the first plunger 11 comprises a first plunger tube 111 and a first plunger rod 112, wherein the first plunger tube 111 is substantially cylindrical, and a threaded connection portion 1111 is arranged at the distal end of the first plunger tube 111, which is used to be screwed with the first connecting valve 12, so as to improve the stability of the connection between the first plunger tube 111 and the first connecting valve 12. The first plunger rod 112 is movably arranged in the first plunger tube 111, and a plunger head 1121 is arranged at the distal end of the first plunger rod 112, which is made of silica gel or rubber, so as to ensure the sealing between the plunger head 1121 and the first plunger tube 111.

[0036] Referring to Figure 3 As shown, the first connecting valve 12 comprises a first valve body 121 and a first valve core 122. In the embodiment, the first valve body 121 is cylindrical, and a central hole 120 is arranged on the first valve body 121 in the axial direction, and a first valve port 1211, a second valve port 1212 and a third valve port 1213 are arranged on the outer wall of the first valve body 121 in the radial direction, which are all communicated with the central hole 120, wherein the included angle between any two adjacent valve ports is 120°, and the threaded connection portion 1111 of the first plunger tube 111 is connected with the first valve port 1211, the second valve port 1212 is used to be connected with the first connecting tube 3, and the third valve port 1213 is used to be emptied. The first valve core 122 is cylindrical, and a curved passage 1221 is arranged on the first valve core 122 and penetrates the outer wall of the first valve core 122, and the curved angle of the curved passage 1221 is 120°, and the first valve core 122 is movably arranged in the central hole, so that the two ends of the curved passage 1221 can be communicated with any two of the first valve port 1211, the second valve port 1212 and the third valve port 1213, respectively. When the two ends of the curved passage 1221 are communicated with the first valve port 1211 and the second valve port 1212, respectively, the first plunger 11 can be used to suck air or physiological saline; when the two ends of the curved passage 1221 are communicated with the first valve port 1211 and the third valve port 1213, respectively, the first plunger 11 can be used to discharge air or physiological saline to the outside, so as to be ready for the next time of sucking air or physiological saline.

[0037] Referring to Figure 4 As shown in the above embodiment, the perfusion part 1 further comprises a plunger driving part 13, which is connected with the first plunger rod 112 to drive the first plunger rod 112 to reciprocate in the first plunger tube 111, and the plunger driving part 13 can be connected with a control system to accurately control the moving distance of the first plunger rod 112 by using the control system.

[0038] Continuing to refer to Figure 4As shown in the above embodiments, the perfusion part 1 further comprises a valve driving part 14 connected with the first valve core 122 for driving the first valve core 122 to rotate around the central axis of the first valve body 121, so that the two ends of the curved channel 1221 are respectively communicated with any two of the first valve port 1211, the second valve port 1212 and the third valve port 1213. The valve driving part 14 can also be connected with the control system, so as to accurately control the rotation angle of the first valve core 122 by the control system.

[0039] In an embodiment, the chain composition preparation device further comprises a displacement sensor arranged on one side of the first piston rod 112 for detecting the movement distance of the first piston rod 112 and feeding back to the control system; at the same time, the chain composition preparation device further comprises an angle sensor arranged on one side of the first valve core 122 for detecting the rotation angle of the first valve core 122 and feeding back to the control system.

[0040] Similarly, the bolus part 2 comprises a second plunger 21 and a second connecting valve 22. The structure of the second plunger 21 and the second connecting valve 22 is the same as that of the first plunger 11 and the first connecting valve 12, which will not be described here. The difference is that the valve body of the second connecting valve 22 is provided with fourth valve port 221, fifth valve port 222 and sixth valve port 223 which are communicated with each other, the second plunger 21 is installed at the fourth valve port 221, the sixth valve port 223 is used for connecting with the saline supply part, and the fifth valve port 222 is communicated with the second valve port 1212 through the first connecting pipe 3, that is, the second connecting valve 22 does not have emptying design. After the perfusion part 1 forms the gas-liquid alternating agent, the fourth valve port 221 and the sixth valve port 223 are communicated to suck physiological saline into the second connecting valve 22, and then the fourth valve port 221 and the fifth valve port 222 are communicated to push the saline into the first connecting pipe 3, so as to push the gas-liquid mixed agent in the second connecting pipe 2 into the infusion pipe 6.

[0041] Similarly, the bolus part 2 also has a piston driving part and a valve driving part, which have the same functions as the piston driving part 13 and the valve driving part 14 in the perfusion part 1, which will not be described here. Similarly, the bolus part 2 also has a displacement sensor and an angle sensor for detecting the movement distance of the second piston rod in the second plunger 21 and the rotation angle of the second valve core in the second connecting valve 22.

[0042] Reference Figure 5As shown in the above embodiment, the center of the distribution valve 5 is rotatably provided with a common connection end 51, and a plurality of distribution ports 52 are formed on the outer wall of the distribution valve 5. In this embodiment, the distribution ports 52 are six, i.e., the distribution valve 5 is a six-distribution valve, and in other embodiments, the number of distribution ports 52 can be determined according to actual needs. The common connection end 51 can be connected with a driving device (for example, a stepper motor), so that the common connection end 51 is driven to rotate around the central axis of the distribution valve 5 by the driving device, thereby being in communication with any distribution port 52. The proximal end of the second connecting pipe 4 is connected with the first connecting pipe 3, and the distal end of the second connecting pipe 4 is connected with the common connection end 51. One of the six distribution ports 52 is connected with the infusion pipe 6 (i.e., the distribution port 52 for delivering liquid), and the remaining distribution ports 52 are used to be connected with different gas supply parts or liquid supply parts, such as CO2 supply part, contrast agent supply part, alcohol supply part, and physiological saline supply part, etc. When the common connection end 51 is in communication with different medicament distribution ports 52, different gases or liquids can be sucked by the perfusion part 1 to form a gas-liquid alternating type medicament; when the common connection end 51 is in communication with the infusion pipe 6 through the distribution port 52, the gas-liquid alternating type medicament can be pushed into the infusion pipe 6 by the bolus part 2.

[0043] Similarly, the distribution valve 5 has a plurality of distribution ports (six are shown in the figure), one of which is connected with the infusion pipe 6 (as an output port), and the remaining five distribution ports can be respectively connected with different media (gas or liquid) to combine different media (five distribution ports, up to five different media) into a chain composition of different media alternately, such as first medium-second medium-third medium-first medium-second medium-third medium-first medium-second medium-third medium......, first medium-second medium-third medium-second medium-third medium-second medium-third medium......, first medium-second medium...... fifth medium-second medium...... fifth medium-second medium...... fifth medium, first medium-second medium-first medium-third medium-first medium-fourth medium-first medium-fifth medium-first medium-second medium-first medium......, etc.

[0044] It can be understood that the number of distribution ports of the distribution valve is at least three, and can also be four, five, etc., which can be selected according to needs. The more the number of distribution ports, the more the types of media in the chain composition prepared.

[0045] It needs to be understood that in the above embodiment, the perfusion part 1 and the bolus part 2 are connected in parallel with the distribution valve 5 through the second connecting pipe 4, and the distribution valve 5 is located downstream of the perfusion part 1 and the bolus part 2. In specific operation, the distribution valve 5 cooperates with only one of the perfusion part 1 or the bolus part 2 at the same time. Meanwhile, the distribution valve 5 has a plurality of distribution ports 52, and the distribution ports 52 used are different when the distribution valve 5 cooperates with the perfusion part 1 or the bolus part 2.

[0046] When the distribution valve 5 cooperates with the perfusion part 1, the different distribution ports 52 are connected with the common connecting end 51 by adjusting, and at this time, the distribution ports 52 need to be externally connected with a medicament supply device (for example, a CO2 supply device, a saline supply device, etc.) to use the continuous suction of the perfusion part 1 to suck the gas or liquid from the different medicament supply devices through the distribution valve 5 into the second connecting pipe 4, so as to realize the configuration of the medicament, which is a gas-liquid alternating medicament, and the specific types of gas and liquid can be selected as needed. At this time, the bolus part 2 is in a non-working state, that is, during the process of medicament configuration, the bolus part 2 is closed.

[0047] When the distribution valve 5 cooperates with the bolus part 2, the distribution port 52 for delivering liquid is connected with the common connecting end 51 (at this time, the distribution port 52 connected with the medicament supply device is in a non-working state), so as to use the bolus part 2 to push the medicament from the second connecting pipe 4 through the distribution valve 5 into the infusion pipe 6 for infusion for the patient. At this time, the perfusion part 1 is in a non-working state, that is, during the process of medicament bolus, the perfusion part 1 (the first connecting valve 12) is closed.

[0048] Therefore, the cooperation of the distribution valve 5 with the perfusion part 1 realizes the configuration of the medicament, and the cooperation of the distribution valve 5 with the bolus part 2 realizes the bolus of the medicament, so as to complete the integrated operation of dispensing and infusion, thereby improving the convenience of the overall operation and being beneficial to realize the dispensing and injection of the medicament by the doctor on the operation site.

[0049] In addition, in the above embodiment, since the perfusion part 1 needs to continuously suck to configure the medicament, an emptying port needs to be arranged on the perfusion part 1; however, the bolus part 2 needs better sealing to avoid the entry of external excess gas into the second connecting pipe 4, so the bolus part 2 is directly connected with the external saline supply part to directly suck physiological saline, and the configured medicament is pushed into the infusion pipe 6 through the injection of the physiological saline, and meanwhile, after the bolus is completed, the second connecting pipe 4 is still full of physiological saline, and there is no gas.

[0050] Reference Figure 1As shown in the above embodiment, the chain composition preparation device further comprises a pressure sensor 7, which is installed on the first connecting pipe 3 between the fifth valve port 222 and the proximal end of the second connecting pipe 4. Thus, the pressure sensor 7 can be used to detect the pressure values in the first connecting pipe 3 and the second connecting pipe 4, so as to ensure that the pressure in the chain composition preparation device is within a normal range.

[0051] In the above embodiment, the first connecting pipe 3 and the second connecting pipe 4 are Teflon pipes, but the specific material of the first connecting pipe 3 and the second connecting pipe 4 is not limited, and in other embodiments, connecting pipes made of other medical materials can also be selected.

[0052] <Second Embodiment>

[0053] Based on the chain composition preparation device in the first embodiment, the application further provides a gas-liquid injection method, which specifically comprises the following steps:

[0054] S1: emptying is performed by using the perfusion part 1.

[0055] Before performing the injection of the medicament, the air in the chain composition preparation device needs to be exhausted first, so as to avoid injecting too much air into the human body and causing damage to the human body. Specifically, steps S11-S15 are included:

[0056] S11: the first valve port 1211 and the second valve port 1212 are communicated, and the fourth valve port 221 and the fifth valve port 222 are communicated, at this time, the piston head of the first piston rod 112 is located at the distal end of the first plunger pipe 111, and the piston head of the second piston rod is located at the distal end of the second plunger pipe. At the same time, the common connecting end 51 is connected with the physiological saline supply part through the distribution port 52 by driving the driving device.

[0057] S12: the first piston rod 112 is moved by the piston driving part 13 to suck the air in the first connecting pipe 3 and the second connecting pipe 4, and at the same time, the physiological saline is sucked into the second connecting pipe 4, the volume of air sucked each time is equal to the volume of the first plunger pipe 111, and in this embodiment, up to 250 μl of air can be sucked each time.

[0058] S13: the first valve core 122 is rotated by the valve driving part 14 to make the first valve port 1211 communicate with the third valve port 1213.

[0059] S14: the first piston rod 112 is moved by the piston driving part 13 to discharge the air to the outside through the third valve port 1213, at this time, the first piston rod 112 returns to the initial position in step S11, so as to be ready for the next air suction.

[0060] S15: The valve driving part 14 controls the rotation of the first valve core 122 to make the first valve port 1211 communicate with the second valve port 1212.

[0061] S16: Steps S11-S15 are repeated until the first connecting pipe 3 and the second connecting pipe 4 are filled with physiological saline.

[0062] S2: The perfusion part 1 is configured with the medicament.

[0063] When the air in the first connecting pipe 3 and the second connecting pipe 4 is exhausted, different medicaments need to be configured according to the needs of the patient. Taking the configuration of a gas-liquid alternating dosage form of 10 μl CO2+10 μl alcohol as an example, the specific steps include the following:

[0064] S21: The valve driving part 14 controls the rotation of the first valve core 122 to make the first valve port 1211 communicate with the second valve port 1212; and the common connecting end 51 is connected to the CO2 supply part through the distribution port 52 by the driving device.

[0065] S22: The piston driving part 13 drives the first piston rod 112 to move to suck 10 μl of physiological saline in the first connecting pipe 3 and the second connecting pipe 4, and at the same time, 10 μl of CO2 is sucked into the second connecting pipe 4.

[0066] S23: The valve driving part 14 controls the rotation of the first valve core 122 to make the first valve port 1211 communicate with the third valve port 1213.

[0067] S24: The piston driving part 13 drives the first piston rod 112 to move to discharge 10 μl in the first plunger pipe 111 to the outside through the third valve port 1213.

[0068] S25: The valve driving part 14 controls the rotation of the first valve core 122 to make the first valve port 1211 communicate with the second valve port 1212, and the common connecting end 51 is connected to the alcohol supply part through the distribution port 52 by the driving device.

[0069] S26: The piston driving part 13 drives the first piston rod 112 to move to suck 10 μl of physiological saline in the first connecting pipe 3 and the second connecting pipe 4, and at the same time, 10 μl of alcohol is sucked into the second connecting pipe 4.

[0070] S27: The valve driving part 14 controls the rotation of the first valve core 122 to make the first valve port 1211 communicate with the third valve port 1213.

[0071] S28: The piston driving part 13 drives the first piston rod 112 to move to discharge 10 μl in the first plunger pipe 111 to the outside through the third valve port 1213.

[0072] S29: The first valve core 122 is controlled to rotate by the valve driving part 14, so that the first valve port 1211 communicates with the second valve port 1213, and steps S21-S28 are repeated until the gas-liquid alternating agent type medicament of the set volume is arranged in the second connecting pipe 4.

[0073] It can be understood that, in the embodiment, the gas-liquid alternating agent type medicament of 10 μl CO2+10 μl alcohol arranged by the perfusion part 1 is only one of the implementation manners, and in other embodiments, medicaments of three materials or four materials can also be arranged, and the specific manner is similar to the above steps, only the common connecting end 51 is connected with different medicament supply parts through the distribution port 52, which will not be described here.

[0074] S3: The medicament is pushed into the infusion pipe 6 by the pushing part 2.

[0075] When the medicament is arranged, the medicament needs to be input into the patient's body, which is realized by the pushing part 2, and the perfusion part 1 is in standby state at this time. Specifically, the following steps are included:

[0076] S31: The second valve core is controlled to rotate by the valve driving part of the pushing part 2, so that the fourth valve port 221 communicates with the sixth valve port 223; and the common connecting end 51 is connected with the infusion pipe 6 through the distribution port 52 by the driving device.

[0077] S32: The second piston rod is driven to move by the piston driving part of the pushing part 2, so that a certain amount of physiological saline is sucked into the second plunger pipe through the sixth valve port 223, wherein the certain amount of physiological saline is determined according to the volume of the medicament to be injected.

[0078] S33: The second valve core is controlled to rotate by the valve driving part of the pushing part 2, so that the fourth valve port 221 communicates with the fifth valve port 222.

[0079] S34: The second piston rod is driven to move by the piston driving part of the pushing part 2, so that the certain amount of physiological saline in the second plunger pipe is pushed into the first connecting pipe 3. Since the first connecting pipe 3 and the second connecting pipe 4 have been filled with physiological saline and the arranged medicament, the physiological saline injected from the pushing part 2 into the first connecting pipe 3 will push the gas-liquid alternating agent type medicament of 10 μl CO2+10 μl alcohol at the far end of the second connecting pipe 4 through the distribution valve 5 and into the infusion pipe 6.

[0080] It should be understood that, since the medicament at the far end of the second connecting pipe 4 has been pushed into the infusion pipe 6, the second connecting pipe 4 is filled with physiological saline again, and the above steps can be used for the next medicament arrangement.

[0081] S4: connecting the infusion tube 6 with the infusion device to perform injection of the medicament.

[0082] In summary, the chain composition preparation device and injection method provided by the embodiments of the present application can realize the integration of medicament configuration and medicament injection, thereby improving the convenience of medicament injection and being conducive to improving the injection efficiency of medicament. Further, by selecting a distribution valve with three or more distribution ports, a chain composition with different media alternation can be realized by only using one priming part and one bolus part, especially when realizing a chain composition with three or more different media alternation, only one priming part and one bolus part are needed, thereby improving the preparation efficiency and reducing the volume and manufacturing cost of the chain composition preparation device.

[0083] The present application has been described in detail above. Any obvious modification made to the present application by those skilled in the art without departing from the essential content of the present application shall constitute an infringement of the patent right of the present application and shall bear the corresponding legal responsibility.

Claims

1. A chain-type composition preparation apparatus, characterized in that, include: A distribution valve, comprising multiple distribution ports; The injection section is used for alternately pumping different media; The injection section is used to push the formed chain composition; The first connecting tube connects the infusion section and the injection section, forming an internal flow path for the transmission of the chain composition. The second connecting pipe has its proximal end connected to the first connecting pipe and its distal end connected to the common connection end of the distribution valve. An infusion tube is connected to one of the dispensing ports of the dispensing valve, and the remaining dispensing ports of the dispensing valve are used to connect to different gas or liquid supply units; The infusion section is connected to the selected supply section through the first connecting pipe, the second connecting pipe and the distribution valve, so as to alternately draw gas or liquid from the distribution valve and form a chain composition of different media alternating in the second connecting pipe. The injection section is connected to the second connecting tube via the first connecting tube, and is used to push the chain composition located in the second connecting tube so that it enters the infusion tube through the dispensing valve.

2. The chain composition preparation apparatus as described in claim 1, characterized in that, The infusion section includes a first plunger and a first connecting valve. The first connecting valve has at least a first valve port, a second valve port, and a third valve port that can be connected in pairs. The first plunger is installed at the first valve port, and the third valve port is a venting valve port.

3. The chain composition preparation apparatus as described in claim 2, characterized in that, The injection unit includes a second plunger and a second connecting valve. The second connecting valve has at least a fourth valve port, a fifth valve port, and a sixth valve port that can be connected to each other in pairs. The second plunger is installed at the fourth valve port. The sixth valve port is used to connect to the brine supply unit. The fifth valve port and the second valve port are connected through the first connecting pipe.

4. The chain composition preparation apparatus as described in claim 3, characterized in that, It also includes a pressure sensor, which is mounted on the first connecting pipe between the fifth valve port and the proximal end of the second connecting pipe.

5. The chain composition preparation apparatus as described in claim 1, characterized in that, Both the first connecting pipe and the second connecting pipe are Teflon pipes.

6. The chain composition preparation apparatus according to claim 2, characterized in that, The infusion unit further includes a piston drive unit. The first plunger includes a first plunger tube and a first piston rod. The distal end of the first plunger tube is connected to the first valve port. The first piston rod is movably inserted inside the first plunger tube. The piston drive unit is connected to the first piston rod to drive the first piston rod to reciprocate within the first plunger tube.

7. The chain composition preparation apparatus according to claim 2, characterized in that, The infusion section further includes a valve drive section. The first connecting valve includes a first valve body and a first valve core. A central hole is provided on the first valve body along the axial direction, and a first valve port, a second valve port and a third valve port are provided on the outer wall of the first valve body along the radial direction. The first valve port, the second valve port and the third valve port are all connected to the central hole. The first valve core has a curved channel that penetrates the outer wall of the first valve core. The first valve core is rotatably inserted into the central hole and is connected to the valve driving part. The valve driving part is used to drive the first valve core to rotate around the central axis of the first valve body so that the two ends of the curved channel are respectively connected to any two of the first valve port, the second valve port and the third valve port.

8. A method for preparing a chain composition using the chain composition preparation apparatus as described in any one of claims 1 to 7.

9. The method for preparing the chain composition as described in claim 8, characterized in that, The dispensing valve is used to prepare a chain composition of alternating media, including at least three different media.

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