An isolated packaging structure and a forming process thereof

Abstract

The present application relates to the technical field of efficacy essence package, in particular to an isolated package structure and a forming process thereof, the present application is improved on the basis of the existing BFS technology, can automatically complete blowing, filling, throwing, sealing all process and monitoring, the equipment occupies small area, the energy consumption of production process is less, so the comprehensive production cost of BFS aseptic filling process is not higher than traditional aseptic filling process, but the product quality and comprehensive economic benefit are much higher than traditional aseptic filling process.

Description

Technical Field

[0001] This invention relates to the field of packaging materials for functional essences, and in particular to an isolation packaging structure. Background Technology

[0002] As research into the use of potent serums deepens, more and more aspects of these serums are being discovered.

[0003] For example, with dry serum formulations, there's no need to worry about microbial growth in an aquatic environment causing the active ingredients to deteriorate or oxidize (due to moisture). Therefore, there's no need to add preservatives or antibacterial agents, which can also cause side effects on the body or skin. The only difference is that the dry serum formulation needs to be dissolved in water before use.

[0004] On the other hand, storing some active ingredients in combination can lead to instability in their properties, thus affecting their efficacy. For example, mixing substances with strong antioxidant activity with polysaccharides or proteins can reduce their activity; mixing various acidic substances with proteins can also reduce their activity; mixing proteins with carbonyl compounds or sugars can produce non-enzymatic glycosylation reactions, all of which can lead to a decrease in the efficacy of the ingredients. However, when these active ingredients are used in combination (together), the effects are often better.

[0005] From this perspective, many active ingredients and their excipients in serums are suitable for "separate storage and mixed use." Existing technologies also include packaging for separately storing serums. For example, patent EP15173946.3 discloses a container capable of separately storing two flowable substances. Specifically, the container assembly has a first container operably accommodating a second container. The first container is configured to contain a first flowable substance, and the second container is configured to contain a second flowable substance. The second container is fracture-resistant, preferably fractured by manipulation through the first container, wherein the second flowable substance can be mixed with the first flowable substance to form a mixture.

[0006] However, existing isolation packaging structures using traditional aseptic filling processes are inefficient and cannot guarantee the quality of the essence. Specifically: 1. In traditional aseptic filling processes, the equipment cannot truly achieve CIP / SIP, especially since key components require manual assembly and debugging before use, resulting in low efficiency and potential contamination of the equipment and sterile environment. 2. Containers and components are purchased externally and must be cleaned and sterilized separately before assembly, a complex and labor-intensive process. Each step carries the risk of contamination, failing to meet the requirement of sterility throughout the entire process. 3. High-temperature sterilization alters the effective components of the essence and generates "new substances." Some products, due to raw material and process limitations, cannot undergo high-temperature sterilization, failing to meet the requirements of aseptic pharmaceutical manufacturing processes. 4. Equipment components and delivery pipelines after sterilization and filtration cannot achieve CIP / SIP. Equipment components require manual assembly and debugging before filling, and personnel are needed in the filling area, introducing many uncontrollable factors. Non-degradable waste pollutes the environment, failing to meet the requirements of user safety, operator safety, and environmental safety. Summary of the Invention

[0007] To address the issues of low efficiency and difficulty in quality control in the molding process of existing dual-cavity isolation packaging structures, this invention provides an isolation packaging structure and its molding process.

[0008] The technical solution adopted by this invention to solve its technical problem is:

[0009] One aspect of the present invention provides a molding process for an isolation packaging structure, comprising the following steps:

[0010] Provide the first container,

[0011] The first formulation is filled into the first container, and the first container is sealed.

[0012] Using BFS technology to form preforms by extrusion;

[0013] Using BFS technology, a second container is blown into shape according to the mold and then filled with the second formulation;

[0014] The first container is placed into the second container;

[0015] The second container is encapsulated using BFS technology to form a complete package;

[0016] After sealing, the mold is opened and the package is sent out.

[0017] According to one embodiment of the present invention, a coating is formed on the surface of the first container, the coating being located on the inner surface and / or outer surface of the first container.

[0018] According to one embodiment of the present invention, a coating is formed on the surface of the first container, the coating being formed by a plasma plating process, wherein the material of the thin-film organic coating of the plasma plating is polyethylene, polystyrene, siloxane, fluoropolymer, amination, hydroxyethyl methacrylate, silane, or vinyl.

[0019] According to one embodiment of the present invention, a coating is formed on the surface of the first container, wherein the coating process is a Sidel Actis coating, a DLC coating, or a Parylene coating.

[0020] According to one embodiment of the present invention, the second formulation is filled using a blow-fill mechanism, and then the first container is dispensed. The blow-fill mechanism includes a blow-fill needle, which is connected to the flow pump through a first branch channel and to the dispensing device through a second branch channel. An air pump is provided at the end of the blow-fill needle. The dispensing device delivers the first container into the blow-fill needle and dispenses it into the second container using the pressure of the air pump.

[0021] According to one embodiment of the present invention, the second formulation is filled using a blow-fill mechanism, and then a robotic arm is used to deliver the first container into the second container.

[0022] According to one embodiment of the present invention, the first formulation is a solid or a liquid, and the second formulation is a liquid.

[0023] In another aspect, the present invention provides an isolation packaging structure manufactured using the above-described isolation packaging structure molding process, comprising a first container and a second container forming two independent cavities, wherein the first container is placed inside the second container, and a coating is formed on the inner and / or outer surfaces of the first container.

[0024] According to one embodiment of the present invention, the coating is made of parylene and the thickness of the coating is 0.5 μm-1 μm.

[0025] According to one embodiment of the present invention, the diameter of the first container is 0.5-1 cm, the length is 20-30 mm, and the wall thickness is 1-2 mm.

[0026] According to one embodiment of the present invention, the second container contains a liquid essence, and the first container contains a lyophilized powder.

[0027] Beneficial effects

[0028] This invention improves upon existing BFS technology, enabling the automatic completion and monitoring of the entire process of blowing, filling, dispensing, and sealing. The equipment occupies a small area and consumes less energy during production. Therefore, the overall production cost of the BFS aseptic filling process is not higher than that of the traditional aseptic filling process, but the product quality and overall economic benefits are significantly higher.

[0029] BFS technology can be used to automatically complete CIP / SIP under computer program control, with reliable reproducibility and high efficiency.

[0030] BFS technology enables aseptic filling without the need for high-temperature sterilization, ensuring stable product quality. By simply changing the mold, it can be used for various forms of aseptic product filling and the production of various aseptic containers.

[0031] Products packaged using BFS technology are of high quality. Attached Figure Description

[0032] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0033] Figure 1 This is a schematic diagram of the isolation packaging structure in this embodiment;

[0034] Figure 2 This is a schematic diagram of the structure of the first container in this embodiment;

[0035] Figure 3 This is a schematic diagram of the fracture structure of the first container in this embodiment;

[0036] Figure 4 This is a schematic diagram of the blowing and irrigation mechanism in this embodiment;

[0037] Figure 5 This is a schematic diagram of the structure of the vibratory feeding device in this embodiment;

[0038] Figure 6 This is a schematic diagram of the deflection guide component structure in this embodiment.

[0039] in,

[0040] First container 1, first receiving cavity 11, first sub-container 12, inclined surface 13;

[0041] Second container 2;

[0042] Fracturing structure 3, thinning part 31, thinning line 32, misaligned engagement part 33, bonding line 34;

[0043] The blowing and irrigation mechanism 4, the blowing and irrigation needle 41, the first branch channel 43, the second branch channel 42, the base 44, the pneumatic push rod 45, the air pump 46, and the feeding channel 47;

[0044] Vibrating feeding device 5, vibrating feeding plate 51, transfer channel 52, air blowing assembly 53, deflection guide assembly 54. Detailed Implementation

[0045] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the present invention or its application or use. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0046] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0047] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following figures denote similar items; therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0048] In the description of this invention, it should be understood that the orientation or positional relationship indicated by directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" is generally based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing this invention and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this invention; the directional terms "inner" and "outer" refer to the inner and outer contours relative to the outline of each component itself.

[0049] For ease of description, spatial relative terms such as "above," "on top of," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "on top of" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0050] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore should not be construed as limiting the scope of protection of this invention.

[0051] This invention proposes an isolation packaging structure that can isolate different formulations for mixing during use. However, existing isolation packaging structures all use traditional injection molding and filling methods, which are inefficient and cannot guarantee the quality of the essence.

[0052] This invention utilizes BFS (Blow-Fill-Seal) technology for molding. BFS technology refers to a three-in-one (blow-fill-seal) aseptic filling technology, an advanced technology that enables the molding of packaging containers, filling of pharmaceutical solutions, and sealing of containers on a single machine in a fully controlled environment, ensuring the sterility of the pharmaceutical packaging and its contents. Accordingly, the isolation packaging structure molded using BFS technology can achieve fully automated packaging, greatly improving production efficiency while ensuring the quality of the essence during the molding process.

[0053] One aspect of this invention provides a process for forming an isolation packaging structure, which utilizes BFS technology to achieve aseptic filling of the essence, and further improves upon this process to achieve aseptic filling of an enclosed dual-cavity packaging structure for the storage of different formulations, ensuring the quality of the essence.

[0054] The molding process for the isolation packaging structure in this embodiment includes the following steps:

[0055] S1 provides a first container 1, such as Figure 1 As shown, a cavity is formed within the first container 1. The first container 1 can be purchased directly or manufactured using extrusion stretch molding, where heated resin is continuously passed through a mold using an extruder to extrude the desired product shape. Alternatively, it can be manufactured using injection molding, where molten thermoplastic is injected into a mold under high pressure using an injection molding machine, and then cooled and solidified to obtain the product. Another option is blow molding, where compressed air pressure is used to blow a thermoplastic preform enclosed in a mold into a hollow product.

[0056] The first container 1 is preferably made of plastic. In order to facilitate the breaking of the first container 1 so that the isolated essences can be mixed, the first container 1 needs to be made into a shape with a fracture structure. The specific fracture structure can adopt the fracture structure of existing technology, which will not be described in detail here.

[0057] After the first container 1 is manufactured, the first preparation needs to be filled into the first container 1 and the first container 1 needs to be sealed. Preferably, a coating is made on the inner or outer surface of the first container 1 to ensure sealing and isolation. The first container 1 is then filled and sealed for use.

[0058] In this embodiment, the first container 1 can be produced and sold independently.

[0059] According to one embodiment of the invention, the coating process preferably uses PlasmaPlus nanocoating, achieved on the inner and outer walls of the packaging through an innovative, low-cost PlasmaPlus plasma plating process. PlasmaPlus nanocoating, developed by Plasmatreat, is a transparent, glassy coating that is elastic, impact-resistant, and abrasion-resistant. This nanocoating acts as a barrier, extending the product's shelf life. The materials for the thin-film organic coating of the plasma plating can be, but are not limited to, polyethylene, polystyrene, siloxanes, fluoropolymers, aminations, hydroxyethyl methacrylate, silanes, and vinyl groups.

[0060] According to one embodiment of the present invention, the preferred coating process is Sidel Actis coating, which is deposited on the inner surface of the packaging using Actis plasma spraying technology. Sidel Actis coating provides barrier protection for the product inside the packaging, extends product shelf life, and achieves lightweight packaging.

[0061] According to one embodiment of the present invention, the preferred coating process is a diamond-like carbon (DLC) coating, also known as an amorphous carbon coating. This coating is formed on the surface of the packaging by physical vapor deposition (PVD) in a vacuum environment. This coating is both thin and hard, providing barrier protection. Furthermore, it possesses excellent machinability, corrosion resistance, high hardness, and abrasion resistance, significantly reducing scratches and abrasions on the surface of objects.

[0062] According to one embodiment of the present invention, the preferred coating process is a Parylene coating, which is a polymer of paraxylene. Depending on the molecular structure, Parylene can be classified into various types such as N-type, C-type, F-type, and HT-type. A completely covering polymer film coating is formed on the surface of the packaging through a vacuum pyrolysis vapor deposition process. This film coating is extremely thin and uniform in thickness, dense and pinhole-free, transparent and tough, contains no additives, does not damage the substrate, and has excellent electrical insulation and barrier properties. It is one of the most effective moisture-proof, mildew-proof, corrosion-proof, and salt spray-proof coating materials available today. It can be coated onto surfaces of various shapes, including sharp edges, cracks, and inner surfaces.

[0063] S3 utilizes BFS technology to extrude preforms, allowing for direct use of existing aseptic filling techniques. Specifically, plastic granules are continuously extruded into preforms by a rotating screw at a temperature of 170~230℃ and a pressure of 350 bar. The preform, protected by sterile air, passes through the mold. When the preform reaches the correct length, the main mold closes and seals the bottom of the preform. A cutter cuts the preform, while the top of the preform is held in place by an opening. Sterile air continues to protect the open preform within the mold.

[0064] S4 utilizes BFS technology to blow-form the second container 2 according to the shape of the mold and fill it with the second formulation. Specifically, the mold is quickly transferred to the blow / fill station, and the sterile air in the equipment's built-in Class A air shower protects the blow-forming, filling, and sealing stations. The blow-fill needle mechanism quickly descends to the neck of the container and blows it into the shape of the mold using clean compressed air (vacuum method for small container forming). The essence, measured using the time-pressure method, is immediately filled into the container, and the sterile air inside the container is expelled.

[0065] S5. The first container 1 is placed into the second container 2.

[0066] It should be noted that, as Figure 1 and 4As shown, this embodiment uses an improved blowing and irrigation mechanism 4 to complete the three actions of blowing, irrigation, and dispensing. Specifically, the blowing and irrigation mechanism 4 includes a blowing and irrigation needle. The blowing and irrigation needle is connected to the flow pump through a first branch channel 43. The blowing and irrigation needle is connected to the dispensing device through a second branch channel 42. An air pump is provided at the end of the blowing and irrigation needle. The dispensing device sends the first container 1 into the blowing and irrigation needle and uses the pressure of the air pump to dispense it into the second container 2.

[0067] According to one embodiment of the present invention, the dispensing device includes a base 44, a pneumatic push rod 45 fixed to the base 44, and a vibrating feeding device 5. A pushing channel for the passage of the first container 1 is formed in the base 44, and a feeding channel 47 is formed on one side of the base 44. The feeding channel 47 is connected to the output end of the vibrating feeding device 5. The first container 1 is sequentially fed into the pushing channel, and then the pneumatic push rod 45 pushes the first container 1 into the filling needle. Preferably, before the pneumatic push rod 45 is activated, the flow pump is started for filling. Then the pneumatic push rod 45 pushes the first container 1 into the filling needle. After the first container 1 adjusts its posture, the air pump 46 is started to press the first container 1 to the filling port, so that the first container 1 and the preparation move downward at the same time. In this way, the first container 1 can be protected by the preparation, so that the first container 1 will not be directly pressed into the second container 2 and rupture. In addition, in order to pursue filling speed, the pressure of the flow pump is relatively high, and the impact of the formulation on the blow-fill needle is relatively large. However, the pressure of the air pump 46 can cleverly reduce the lateral impact of the formulation on the blow-fill needle.

[0068] According to one embodiment of the present invention, the vibrating feeding device 5 includes a vibrating feeding plate 51 and a transfer channel 52. The vibrating feeding plate 51 feeds the first container 1 into the feeding channel 47 via the transfer channel 52. Preferably, the first side of the transfer channel 52 is provided with an air blowing component 53, which can be used to remove defective products. The second side of the transfer channel 52 is provided with a deflection guide component 54 opposite to the air blowing component 53.

[0069] Specifically, the deflection guide assembly 54 includes a deflection arm hinged to the second side of the transfer channel 52 and a guide roller located at the free end of the deflection arm. A torsion spring is provided between the deflection arm and the transfer channel 52, and the torsion spring provides a restoring force for the deflection arm. Thus, when the first container 1 is an empty bladder, the blowing assembly 53 can easily blow the first container 1 away from the transfer channel 52. After the first container 1 is filled with the preparation, the blowing assembly 53 can only change the direction of travel of the first container 1, but cannot blow it away from the transfer channel 52. The first container 1 continues to move forward and deflects under the action of the guide roller. After deflection, the first container 1 is sent into the feeding channel 47. Preferably, the feeding channel 47 is inclined, so that the first container 1 can be sent into the pushing channel in an orderly manner by gravity. Furthermore, the outlet of the transfer channel 52 and the feeding channel 47 are movably connected, and the transfer channel 52 does not interfere with the up and down movement of the feeding channel 47. The outlet of the transfer channel 52 is also provided with a top block. After feeding is completed, the top block is lifted to limit the first container 1.

[0070] In gas delivery, it is also necessary to ensure that the container opening time is short and the essence exposure time is even shorter. One filling cycle takes less than 13 seconds, while the container opening time is about 2 to 4 seconds. The time from filling to sealing the container, that is, the exposure time of the liquid, is even shorter.

[0071] This embodiment integrates the dispensing device, flow pump, air pump, and irrigation needle into a single structure. The dispensing device, flow pump, and air pump move up and down simultaneously with the irrigation needle, which makes better use of the space of the BFS equipment.

[0072] According to another embodiment of the present invention, a robotic arm is used to deliver the first container 1 into the first container 1.

[0073] S6 utilizes BFS technology to encapsulate the second container 2, forming a complete package. In this step, the preform between the top of the mold and the opening retaining clip is still in a semi-molten state.

[0074] In the molten state, the head molds are then merged to form the top of the container and seal the second container 2.

[0075] After S7 is sealed, the mold opens, and the second container 2, which has been filled and sealed, is sent out of the machine, and then the next cycle begins.

[0076] In another aspect, the present invention provides an isolation packaging structure manufactured using the above-described isolation packaging structure molding process. The isolation packaging structure includes a first container 1 and a second container 2 forming two independent cavities. The first container 1 is built into the second container 2, and a coating is formed on the inner and / or outer surfaces of the first container 1.

[0077] According to one embodiment of the present invention, the coating is made of parylene and the coating thickness is 0.5 μm-1 μm. Parylene has very good barrier properties and can ensure sealing with minimal layer thickness.

[0078] According to one embodiment of the present invention, the first container 1 has a diameter of 0.5-1cm, a length of 20-30mm, and a wall thickness of 1-2mm.

[0079] According to one embodiment of the present invention, the second container 2 contains liquid essence, and the first container 1 contains lyophilized powder.

[0080] The isolation packaging structure of this embodiment improves the overall impermeability of the first container by coating the surface of the first container, preventing cross-penetration between different preparations during long-term storage; moreover, the coating can improve the overall strength of the first container, ensuring that the first container will not break when it is placed into the second container.

[0081] Preferably, the first container 1 in this embodiment is provided with a rupture structure 3, allowing the consumer to rupture the first container 1 through the second container 2. The rupture structure 3 in this embodiment is a crushing rupture structure, which is simple in structure and allows the consumer to easily destroy the first container 1. Specifically, as shown... Figure 3 As shown, the fracture structure 3 includes a thinning portion 31 and a misaligned engagement portion 33. The thinning portion 31 forms a thinning line 32 on the first container 1, meaning that there is at least one thinning line 32 on the first container 1, and the thickness of the first container 1 on the thinning line 32 is less than that of other parts, so that the first container 1 is more likely to deform with the thinning line 32 as the bending point when under pressure. The misaligned engagement portion 33 forms a bonding line 34 on the first container 1, meaning that the first container 1 is formed by at least two open sub-components misaligned and engaged, and a bonding line 34 is formed at the misaligned engagement point to close the first container 1, so that the first container 1 deforms with the thinning line 32 as the bending point when under pressure and cracks at the bonding line 34, and the first preparation in the first container 1 can be mixed with the second preparation in the second container 2.

[0082] Because the first container 1 is coated, the coating covers the fracture structure 3 inside and / or outside the first container 1, and improves the overall strength of the first container 1. Therefore, in order to more easily and conveniently break the first container 1, this embodiment adopts a fracture structure 3 including a thinning portion 31 and a misaligned engagement portion 33. Under pressure, it is easier to deform at the thinning portion 31 as the bending point and crack at the misaligned engagement portion 33. If only the misaligned engagement portion 33 is used, although it is easy to break the first container 1, the fracture structure 3 is more likely to be broken. While misalignment is common in traditional systems, users typically need to press the misalignment locking part 33 to easily break the first container 1. This embodiment, however, also includes a thinning part 31. The cooperation between the thinning part 31 and the misalignment locking part 33 makes misalignment of the misalignment locking part 33 easier to occur. Furthermore, the first container 1 can be broken by pinching either the thinning part 31 or the misalignment locking part 33. This means that users can easily break the first container 1 from multiple angles and directions without needing to be in a specific position, making it more convenient to use. In addition, the rupture structure 3 of this embodiment has a simple structure and does not require complex piercing devices such as blades or needles.

[0083] Preferably, in this embodiment, the first container 1 is configured as a cylindrical shape with hemispherical ends, the diameter of the cylindrical body and the two hemispherical ends is 5-10mm, the overall length of the first container 1 is 20-30mm, and the wall thickness is 1-2mm. The misaligned engagement portion 33 extends along the longitudinal direction of the first container 1 to form a closed and sealed joint line 34. That is, the first container 1 is formed by two first sub-containers 12 misaligned engagement. The engagement structure of the two first sub-containers 12 can be selected, but is not limited to, using an interference fit or a structure with protrusions and grooves. Since the joint line 34 extends along the longitudinal direction of the first container 1, the area of ​​the fracture surface formed after the first container 1 is broken under pressure is maximized, and the first preparation in the two first sub-containers 12 can be mixed more quickly and fully with the second preparation in the second container 2.

[0084] Furthermore, in this embodiment, the thinning portion 31 also extends longitudinally along the first container 1 to form a closed thinning line 32. Since the aforementioned bonding line 34 extends longitudinally along the first container 1, if the thinning line 32 is provided to extend laterally along the first container 1, i.e., perpendicular to the longitudinal direction, then when the first container 1 is compressed, it will open mainly at the bonding line 34 positions at both ends of the first container 1 with the thinning line 32 as the midpoint, resulting in a small deformation and a small opening area. However, in this embodiment, the thinning line 32 also extends longitudinally along the first container 1. When the first container 1 is compressed, it opens mainly at the bonding line 34 positions on the sidewalls of the first container 1 with the thinning line 32 as the midpoint, resulting in a large deformation and a large opening area. Most preferably, in this embodiment, the bonding line 34 and the thinning line 32 intersect and are perpendicular at both ends of the first container 1, so that the first container 1 can be easily destroyed when subjected to force at any position between the thinning line 32 and the bonding line 34.

[0085] like Figure 3 As shown, in this embodiment, the thinning portion 31 is formed on the inner surface of the first receiving body 1, and the thinning portion 31 is formed in the shape of a groove. The specific shape of the groove can be selected, but is not limited to, triangle, rectangle, arc, etc., and is preferably triangular. Further, the misaligned engaging portion 33 in this embodiment includes mutually cooperating convex and concave portions. Specifically, one of the first sub-receiving bodies 12 ( Figure 3 The edge of the upper one has an outward convex part and an inward concave part from the outside to the inside, and the other first sub-receiver 12 ( Figure 3 The edge of the first sub-receptacle 12 has a concave portion and a convex portion from the outside to the inside. The joint surface between the convex portion and the concave portion of each first sub-receptacle 12 forms a slope 13 from the inside to the outside from the edge. When the first sub-receptacle 1 is pressed, under the guidance of the slope 13, it is easier for the two first sub-receptacle 12 to shift, making the first sub-receptacle 1 easier to break.

[0086] The above are merely preferred embodiments of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A molding process for an isolation packaging structure, characterized in that, Includes the following steps: Provide a first container (1). The first preparation is filled into the first container (1), and the first container (1) is sealed. Using BFS technology to form preforms by extrusion; Using BFS technology, a second container (2) is blown into shape according to the mold and filled with a second formulation. The second formulation is then filled using a blow-fill mechanism (4). The first container (1) is then placed in the mold, causing the first container (1) and the formulation to move downwards simultaneously. The blow-fill mechanism (4) includes a blow-fill needle, which is connected to a flow pump through a first branch channel (43) and to a dispensing device through a second branch channel (42). An air pump (46) is provided at the end of the blow-fill needle. The dispensing device feeds the first container (1) into the blow-fill needle. The first container (1) is fed into the second container (2) by the pressure of the air pump (46). The feeding device includes a base (44), a pneumatic push rod (45) fixed to the base (44), and a vibrating feeding device (5). A pushing channel for the first container (1) to pass through is formed in the base (44). A feeding channel (47) is formed on one side of the base (44). The feeding channel (47) is connected to the output end of the vibrating feeding device (5). The first container (1) is sent into the pushing channel in sequence, and then the first container (1) is pushed into the blowing needle by the pneumatic push rod (45). After the first container (1) is placed into the second container (2), the second container (2) is sealed using BFS technology to form a complete package; After sealing, the mold is opened and the package is sent out. The vibrating feeding device (5) includes a vibrating feeding plate (51) and a transfer channel (52). The vibrating feeding plate (51) feeds the first container (1) into the feeding channel (47) via the transfer channel (52). The first side of the transfer channel (52) is provided with an air blowing assembly (53). The second side of the transfer channel (52) is provided with a deflection guide assembly (54) opposite to the air blowing assembly (53). The deflection guide assembly (54) includes a deflection arm hinged to the second side of the transfer channel (52) and a guide roller located at the free end of the deflection arm. A torsion spring is provided between the deflection arm and the transfer channel (52). The torsion spring provides a restoring force for the deflection arm.

2. The molding process for the isolation packaging structure according to claim 1, characterized in that, A coating is made on the surface of the first container (1), the coating being located on the inner and / or outer surfaces of the first container (1).

3. The molding process for the isolation packaging structure according to claim 1, characterized in that, A coating is made on the surface of the first container (1), the coating being made by a plasma plating process, wherein the material of the thin organic coating of the plasma plating is polyethylene, polystyrene, siloxane, fluoropolymer, hydroxyethyl methacrylate, silane or vinyl.

4. The molding process for the isolation packaging structure according to claim 1, characterized in that, A coating is made on the surface of the first container (1), and the coating process is Sidel Actis coating, DLC coating or Parylene coating.

5. The molding process for the isolation packaging structure according to claim 1, characterized in that, The second preparation is filled using a blow-fill mechanism (4), and then the first container (1) is fed into the second container (2) using a robotic arm.

6. The molding process for the isolation packaging structure according to claim 1, characterized in that, The first formulation is a solid or a liquid, and the second formulation is a liquid.

7. A separating packaging structure, manufactured using the separating packaging structure molding process described in any one of claims 1-6, characterized in that, It includes a first container (1) and a second container (2) and forms two independent cavities. The first container (1) is built into the second container (2). The inner and / or outer surfaces of the first container (1) are coated.

8. The isolation packaging structure according to claim 7, characterized in that, The coating is made of parylene and has a thickness of 0.5 μm to 1 μm.

9. The isolation packaging structure according to claim 7, characterized in that, The first container (1) has a diameter of 0.5-1cm, a length of 20-30mm, and a wall thickness of 1-2mm.

10. The isolation packaging structure according to claim 7, characterized in that, The second container (2) contains liquid essence, and the first container (1) contains freeze-dried powder.

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