A sample analysis device and method

Abstract

A sample analysis device and a sample analysis method, wherein a controller (90) of the device controls an information reader / writer (470) to read reagent information of a reagent container to be loaded on a reagent loading and unloading mechanism (450); the controller (90) controls the reagent information to be written into a memory (91); and before the reagent container to be loaded is transported to a reagent bin (410) by a transport mechanism (490), the controller (90) controls the information reader / writer (470) to write information to a label of the reagent container, so that the reagent information corresponding to the label is set to be unavailable.

Description

Technical Field

[0001] The invention relates to a sample analysis device and method. Background Art

[0002] Sample analysis devices, such as biochemical analyzers, immunoassay analyzers, coagulation analyzers and cell analyzers, are instruments used to analyze and measure samples. Generally, reagents are added to the samples, and the characteristics, chemical composition and concentration of the samples after the reaction with the reagents are measured in a certain way.

[0003] The sample analysis device will continuously consume reagents during the test process, thus generating a large number of empty reagent bottles. The closed management of these empty reagent bottles - for example, how to prevent third parties such as reagent manufacturers from recycling them - is an issue worth studying. Summary of the invention

[0004] The present invention mainly provides a sample analysis device and method, which are described in detail below.

[0005] According to a first aspect, an embodiment provides a sample analysis device, comprising:

[0006] A reaction cup loading component, used for supplying and carrying empty reaction cups;

[0007] A scheduling component, used for scheduling reaction cups;

[0008] A sampling component, used for scheduling samples to be injected;

[0009] The sample dispensing component is used to absorb the sample to be injected and discharge it into the reaction cup;

[0010] The reagent bin includes a placement position for carrying a reagent container; the reagent bin is used to dispatch the carried reagent container to the reagent suction position;

[0011] Reagent dispensing component, used to absorb the reagent and discharge it into the reaction cup;

[0012] A reagent loading and unloading mechanism, used for carrying reagent containers to be loaded and unloaded reagent containers, and receiving reagent containers to be discarded;

[0013] A transport mechanism, used to transport reagent containers between the reagent warehouse and the reagent loading and unloading mechanism; the transport mechanism is used to transport reagent containers to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, and to transport reagent containers to be unloaded or discarded from the reagent warehouse to the reagent loading and unloading mechanism;

[0014] One or more processing units; the processing units are used to receive the reaction cup carrying the sample or the sample prepared by the sample and the reagent dispatched by the dispatching component, and process the liquid in the reaction cup;

[0015] An information reader / writer, capable of sensing a label on a reagent container to read reagent information of the reagent container, and capable of writing information to the label of the reagent container; wherein the reagent information at least includes the reagent amount;

[0016] Memory and controller;

[0017] in:

[0018] The controller controls the information reader to read the reagent information of the reagent container to be loaded on the reagent loading and unloading mechanism; the controller controls the reagent information to be written into the memory; before the reagent container to be loaded is transported to the reagent warehouse by the transport mechanism, the controller controls the information reader to write information to the label of the reagent container, so that the reagent information corresponding to the label is set to be unavailable;

[0019] The controller is used to control the transport mechanism to transport the reagent container to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, and at least update the reagent quantity in the reagent information corresponding to the reagent container in the memory in real time; when the reagent container needs to be discarded, the controller controls the transport mechanism to transport the reagent container to the reagent loading and unloading mechanism for discarding.

[0020] In one embodiment, the controller controls the information reader to write information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable, including:

[0021] The controller controls the information reader / writer to write information to the label of the reagent container so that the reagent information corresponding to the label is zero.

[0022] In one embodiment, when the reagent warehouse carries a reagent container to be unloaded, the controller controls the transport mechanism to transport the reagent container from the reagent warehouse to the reagent loading and unloading mechanism for storage; the controller obtains the latest reagent quantity of the reagent container from the memory, and controls the information reader to write the latest reagent quantity of the reagent container into its label to update the reagent quantity information in its label.

[0023] In one embodiment, the reagent compartment has a working timing cycle, each working timing cycle of the reagent compartment includes a reagent aspiration time period, and one or more of the working timing cycles of the reagent compartment also includes a reagent loading time period;

[0024] The reagent suction time period in the working time sequence cycle of the reagent warehouse is used for the reagent warehouse to dispatch the reagent container it carries to the reagent suction position for the reagent dispensing component to suck;

[0025] The reagent loading time period in the working timing cycle of the reagent chamber is used for loading reagent containers into the reagent chamber, or for unloading or discarding reagent containers from the reagent chamber.

[0026] In one embodiment, the controller controls the transport mechanism to transport the reagent container from the reagent loading and unloading mechanism to the reagent bin, including:

[0027] The controller controls the transport mechanism to transport the reagent container from the reagent loading and unloading mechanism to above a preset position of the reagent bin;

[0028] During the reagent suction time period in the working time sequence cycle of the reagent bin, the controller controls the conveying mechanism to place the reagent container to be loaded into the reagent bin from above a preset position of the reagent bin.

[0029] In one embodiment, the controller controls the transport mechanism to transport the reagent container from the reagent bin to the reagent loading and unloading mechanism, including:

[0030] During the reagent loading time period in the working time sequence cycle of the reagent bin, the controller controls the transport mechanism to take the reagent container out of the reagent bin;

[0031] The controller then controls the transport mechanism to transport the removed reagent container to the reagent loading and unloading mechanism.

[0032] According to a second aspect, an embodiment provides a sample analysis method, comprising:

[0033] Control the dispatching of samples to be tested to the sample suction position;

[0034] Control the reagent compartment to dispatch the reagent container to the reagent suction position

[0035] Controlling the aspiration and discharge of the sample from the sample aspiration position and the aspiration and discharge of the reagent from the reagent aspiration position to prepare the test sample;

[0036] Controlling the measurement of the prepared sample to obtain the test result;

[0037] in:

[0038] When the reagent loading and unloading mechanism carries a reagent container to be loaded, an information reader is controlled to read the label of the reagent container to read the reagent information of the reagent container, and the read reagent information is controlled to be written into a memory, and before the reagent container to be loaded is transported to the reagent warehouse by the transport mechanism, the information reader is controlled to write information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable;

[0039] After controlling the transport mechanism to transport the reagent container to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, at least the reagent quantity in the reagent information corresponding to the reagent container in the memory is updated in real time; when the reagent container needs to be discarded, the transport mechanism is controlled to transport the reagent container to the reagent loading and unloading mechanism for discarding.

[0040] In one embodiment, the control information reader / writer writes information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable, including:

[0041] The information reader / writer is controlled to write information to the label of the reagent container so that the reagent information corresponding to the label is zero.

[0042] In one embodiment, when the reagent bin carries a reagent container to be unloaded, the transport mechanism is controlled to transport the reagent container from the reagent bin to the reagent loading and unloading mechanism for storage; the latest reagent quantity of the reagent container is obtained from the memory, and the information reader is controlled to write the latest reagent quantity of the reagent container into its label to update the reagent quantity information in its label.

[0043] In one embodiment, the reagent compartment has a working time sequence cycle, each working time sequence cycle of the reagent compartment includes a reagent suction time period, and one or more of the working time sequence cycles of the reagent compartment also includes a reagent loading time period:

[0044] During the reagent aspiration time period, the reagent compartment is controlled to dispatch the reagent container it carries to the reagent aspiration position for the reagent dispensing component to aspirate;

[0045] When the reagent loading and unloading mechanism carries a reagent container to be loaded, the conveying mechanism is controlled to convey the reagent container to be loaded from the reagent loading and unloading mechanism to above the preset position of the reagent warehouse, and within the reagent suction time period in the working timing cycle of the reagent warehouse, the conveying mechanism is controlled to place the reagent container to be loaded from above the preset position of the reagent warehouse into the reagent warehouse; or, when the reagent warehouse carries a reagent container to be unloaded or discarded, the conveying mechanism is controlled to take out the reagent container from the reagent warehouse within the reagent suction time period in the working timing cycle of the reagent warehouse, wherein the taken out reagent container will be conveyed to the reagent loading and unloading mechanism by the conveying mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 is a schematic structural diagram of a sample analysis device according to an embodiment;

[0047] Figure 2 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0048] Figure 3 is a schematic structural diagram of a sample analysis device according to another embodiment;

[0049] Figure 4 It is a schematic diagram of the structure of a reagent bin, a reagent loading and unloading mechanism and a transport mechanism according to an embodiment;

[0050] Figure 5It is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in another embodiment;

[0051] Figure 6 It is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism of another embodiment;

[0052] FIG. 7 (a) and FIG. 7 (b) are schematic diagrams of the structures of reagent discs according to two embodiments;

[0053] Figure 8 A schematic diagram of the structure of a reagent disc in another embodiment;

[0054] Fig. 9 It is a structural schematic diagram of a reagent bin, a reagent loading and unloading mechanism and a transport mechanism of another embodiment;

[0055] Fig.10 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0056] Fig.11 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0057] Fig.12 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0058] Fig.13 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0059] Fig.14 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0060] Fig.15 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0061] Fig.16 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0062] Fig.17 This is a schematic structural diagram of a reagent bin, a reagent loading and unloading mechanism, and a transport mechanism in yet another embodiment;

[0063] Fig.18 It is a structural schematic diagram of a sample analysis device according to another embodiment;

[0064] Fig.19 A schematic diagram of the structure of a reagent dispensing component according to an embodiment;

[0065] Fig. 20A schematic diagram of the structure of a reagent dispensing component in another embodiment;

[0066] Fig.21 A schematic structural diagram of a reagent dispensing component in yet another embodiment;

[0067] Fig. 22 A schematic diagram of the structure of a reagent dispensing component according to another embodiment;

[0068] Fig.23 It is a structural schematic diagram of a sample analysis device according to another embodiment;

[0069] Fig.24 It is a structural schematic diagram of a sample analysis device according to another embodiment;

[0070] Fig.25 A flow chart of a sample analysis method according to an embodiment;

[0071] Fig.26 The present invention is a flow chart of a sample analysis method according to another embodiment. DETAILED DESCRIPTION

[0072] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are for making the present application better understood. However, those skilled in the art can easily recognize that some features can be omitted in different situations, or can be replaced by other elements, materials, methods. In some cases, some operations related to the present application are not shown or described in the specification, this is to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations according to the description in the specification and the general technical knowledge in the art.

[0073] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0074] The serial numbers assigned to the components herein, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings).

[0075] Please refer to Figure 1 , is a schematic diagram of the structure of the sample analysis device of some embodiments of the invention. The sample analysis device of some embodiments of the present invention may include a housing 1, a reaction cup loading component 10, a sample injection component 20, a sample dispensing component 30, a reagent compartment 410, a reagent loading and unloading mechanism 450 and a transport mechanism 490, an information reader 470, one or more reagent dispensing components 60, one or more processing units 50, a scheduling component 70, a memory 91 and a controller 90. It should be noted that, Figure 1 The example shown in FIG. 1 is a sample analyzer having two reagent dispensing components 60 and two processing units 50, but those skilled in the art will appreciate that this is only for illustration and does not limit the number of reagent dispensing components 60 and processing units 50 to only two. The following is a detailed description of each component in the sample analyzer.

[0076] The housing 1 is an instrument housing of the sample analysis device, for example, it may have a substantially rectangular or cube-shaped box shape, and its function may be to store some components of the sample analysis device. For example, in some embodiments, the housing 1 includes a first side 1a along a first direction and a second side 1b along a second direction.

[0077] The first direction and the second direction involved in this document, in some embodiments, these two directions, namely the first direction and the second direction, may be perpendicular to each other, for example, the first direction is the Y direction in the figure, and the second direction is the X direction in the figure.

[0078] The cuvette loading component 10 is used to supply and carry empty cuvettes. During operation, the sample analysis device needs to continuously use empty cuvettes to complete test items one by one. The sample analysis device prepares, incubates and measures the sample by adding samples and reagents to the empty cuvettes, thereby obtaining the test results of the items. The cuvette loading component 10 can load the empty cuvettes to a predetermined position, and the sample dispensing mechanism 30 draws the sample from the sample injection component 20 and discharges it into the empty cuvette at the predetermined position.

[0079] The sample introduction component 20 is used to supply a sample rack carrying samples to be tested. In some embodiments, the sample introduction component 20 can be disposed in the housing 1. The sample introduction component 20 can be implemented in a variety of ways.

[0080] In one implementation of the sample injection component 20 , the sample injection component 20 may be a sample injection component 21 , and the sample injection component 21 is used to dispatch a sample rack carrying a sample to a sample suction position. Figure 2As an example, the injection component 21 may include a loading area 21a, an injection channel 21b and an unloading area 21c, wherein a sample suction position may be provided on the injection channel 21b. In the figure, the X direction and the Y direction are perpendicular, the X1 direction and the X2 direction are opposite directions, and the Y1 direction and the Y2 direction are also opposite directions. The user can place the sample rack carrying the sample to be tested in the loading area 21a, and the loading area 21a moves the sample rack in the Y1 direction in the figure to enter the injection channel 21b. The sample rack can move along the X1 direction in the injection channel 21b and pass through the sample suction position. The sample on the sample rack can be sucked by the sample dispensing component 30 when passing through the sample suction position. The sample rack then enters the unloading area 21c from the injection channel 21b along the Y2 direction, and the user can take out the sample rack from the unloading area 21c. The sampling component 21 is more suitable for large-scale sample testing occasions, and the sampling component 21 can be set independently from the sample analysis device. When the sample analysis device needs to be connected to a test system in the form of an assembly line, the sampling component 21 can be directly removed.

[0081] In another implementation of the sample injection component 20 , the sample injection component 20 may be a sample placement area 22 , and the sample placement area 22 is used to place a sample rack carrying samples to be tested. Figure 3 is an example. The sample placement area 22 may have multiple channels 22a, each channel 22a may hold a sample rack, and the user may push the sample rack into the channel 22a along the Y1 direction in the figure; the sample dispensing component 30 may absorb the samples on the sample racks in each channel 22a in turn; after all the samples on the sample racks are absorbed, the user may pull the sample rack out of the channel 22a along the Y2 direction in the figure. The sample placement area 22 does not require the sample rack to be arranged, so it occupies a small volume, which is conducive to reducing the size of the sample analysis device, and is very beneficial to the miniaturization design of the sample analysis device.

[0082] The sample dispensing component 30 is used to absorb the sample to be injected and discharge it into the reaction cup, for example, to absorb the sample from the sample suction position and discharge it into the reaction cup located at the sample adding position. In some embodiments, the sample dispensing component 30 can be arranged in the housing 1. In some embodiments, the sample dispensing mechanism 30 may include a sample needle, and the sample needle is driven by a two-dimensional or three-dimensional driving mechanism to move in a two-dimensional or three-dimensional direction. In some embodiments, the sample needle may be one or more. In order to simplify the motion trajectory and reduce the volume and size of the sample analysis device, the sample suction position and the predetermined position where the reaction cup loading component 10 loads the empty reaction cup can be designed to be on a straight line, for example, on a straight line along the first direction, so that the sample needle only needs to reciprocate between the sample suction position and the above-mentioned predetermined position in the first direction, which not only increases the movement speed of the sample needle, but also helps to reduce the size of the sample analysis device, which is very beneficial for the miniaturization design of the sample analysis device.

[0083] Please refer to Figure 4 , Figure 5 and Figure 6 , Figure 4 It is a structural schematic diagram of the reagent bin 410, the reagent loading and unloading mechanism 450 and the transport mechanism 490. Figure 5 It is a three-dimensional diagram of the reagent chamber 410, the reagent loading and unloading mechanism 450 and the transport mechanism 490 after removing part of the outer shell. Figure 6 It is a top view of the reagent warehouse 410, the reagent loading and unloading mechanism 450 and the conveying mechanism 490 after removing part of the outer shell. In some embodiments, the reagent warehouse 410 is used to carry reagent containers, and the reagent containers in the reagent warehouse 410 are used to be sucked; the reagent loading and unloading mechanism 450 can interact with the reagent warehouse 410, such as real-time reagent loading, real-time reagent unloading, real-time reagent cup throwing, etc.; for example, in some embodiments, the reagent loading and unloading mechanism 450 is used to store reagent containers to be loaded, or to store unloaded reagent containers, or to receive reagent containers to be discarded for discarding. The conveying mechanism 490 is used to transport reagent containers between the reagent warehouse 410 and the reagent loading and unloading mechanism 450; for example, in some embodiments, the conveying mechanism 490 is used to transport reagent containers to be loaded from the reagent loading and unloading mechanism 450 to the reagent warehouse 410, or to transport reagent containers to be unloaded from the reagent warehouse 410 to the reagent loading and unloading mechanism 450, or to transport reagent containers to be discarded from the reagent warehouse 410 to the reagent loading and unloading mechanism 450. The reagent chamber 410 , the reagent loading and unloading mechanism 450 , and the transport mechanism 490 are further described below.

[0084] The reagent chamber 410 will be described first.

[0085] As mentioned above, reagent storehouse 410 is used to carry reagent container, and the reagent container in the reagent storehouse is used to be sucked. Generally, reagent storehouse 410 can provide functions such as refrigeration for the reagent carried, for example, the temperature is maintained between 2 and 16 degrees Celsius, so as to ensure the activity of the reagent. Specifically, reagent storehouse 410 is used to maintain the temperature in it within the range required by the reagent instruction manual. In order to ensure the refrigeration effect, reagent storehouse 410 can be a closed structure, for example, reagent storehouse 410 can be provided with a reagent cover to achieve insulation. In some embodiments, reagent storehouse 410 can be arranged in casing 1. In some embodiments, reagent storehouse 410 includes reagent tray 420, and reagent tray 420 includes at least one circle of reagent track 421 that can rotate, and reagent track includes multiple placement positions 423 for carrying reagent container, and reagent track 421 is rotated to drive the reagent container on its placement position 423 to move. In some embodiments, reagent tray 420 includes multiple circles of reagent track 421, and each reagent track 421 can rotate independently. FIG. 7 (a) shows an example in which the reagent disc 420 has one circle of reagent tracks 421, and FIG. 7 (b) shows an example in which the reagent disc 420 has two circles of reagent tracks 421 that can rotate independently. The reagent tracks 421 can rotate and drive the reagent containers carried thereon to be transported, thereby rotating the reagent containers to the reagent suction position for the reagent dispensing component 60 to absorb the reagent. The reagent disc 420 is further described below in conjunction with the accompanying drawings.

[0086] Please refer to Figure 7 (a). In some specific embodiments, the reagent tray 420 includes a circle of reagent tracks 421, and its placement position 423 can be used to place reagent cups 424. The reagent cups 424 each include one or more cavities for holding reagents required for the project test, and one reagent is placed in one cavity; the reagent tray 420 includes a first driving component for driving the reagent track 421 to rotate, and the first driving component drives the reagent track 421 to rotate, and is used to rotate the cavity of the reagent cup 424 containing the reagent required for the project to the corresponding reagent suction position. In one example, the reagent cup 424 includes at least a first cavity 424a for carrying a first reagent and a second cavity 424b for carrying a second reagent. For example, the reagent cup 424 includes at least a first cavity 424a for carrying a mixed reagent R1 and a second cavity 424b for carrying a trigger reagent R2; the reagent chamber 410 includes a first reagent aspiration position and a second reagent aspiration position different from the first reagent aspiration position, and the first driving component drives the reagent track 421 to rotate and drives the reagent cup 424 to rotate, so as to rotate the first cavity 424a of the reagent cup 424 to the first reagent aspiration position; the first driving component drives the reagent track 421 to rotate and drives the reagent cup 424 to rotate, so as to rotate the second cavity 424b to the second reagent aspiration position.

[0087] Please refer to FIG. 7 (b). In some specific embodiments, the reagent disc 420 includes two circles of reagent tracks 421 that can rotate independently, such as the inner circle reagent track 421 and the outer circle reagent track 421 in the figure. The placement position 423 of the outer circle reagent track 421 can be used to carry the first reagent container; the placement position 423 of the outer circle reagent track 421 can be used to carry the second reagent container. The reagent disc 420 includes a first driving component for driving the outer circle reagent track 421 to rotate, the first driving component drives the outer circle reagent track 421 to rotate and drives the first reagent container to rotate, so as to rotate the first reagent container to the first reagent suction position; the reagent disc 420 also includes a second driving component for driving the inner circle reagent track 421 to rotate, the second driving component drives the inner circle reagent track 421 to rotate and drives the second reagent container to rotate, so as to rotate the second reagent container to the second reagent suction position.

[0088] The above describes two structures of the reagent tray 420. For example, FIG. 7 (a) is an example of placing a reagent cup 424, and FIG. 7 (b) is an example of realizing the reagent tray 420 by using multiple circles of independently rotatable tracks. It can be understood by those skilled in the art that the two methods can also be combined to realize the reagent tray 420 by using multiple circles of independently rotatable tracks, and at least one circle of tracks or the placement position 423 on each circle of tracks can be used to place the reagent cup 424, for example Figure 8 This is an example, the placement position 423 of the reagent track 421 of the inner circle and the reagent track 421 of the outer circle can be used to place the reagent cup 424. By placing all types of reagents required for a test item in the same reagent cup 424, the management of reagents can be facilitated. Of course, in other embodiments, the needle washing solution and diluent can also be placed in the reagent track 421 of the inner circle, and the main reagent for testing, such as the mixed reagent and trigger reagent mentioned above, can be placed in the reagent track 421 of the outer circle.

[0089] The above is some description of the reagent bin 410. During the working cycle, the reagent bin 410 can rotate and dispatch the corresponding reagents required for the test items to the corresponding reagent suction positions of the reagent dispensing component 60, for example, dispatching the first reagent to the first reagent suction position and dispatching the second reagent to the second reagent suction position.

[0090] The reagent warehouse 410 needs to receive reagents to replenish the reagents consumed during the test, and unload the reagents or discard empty reagent containers. Therefore, in some embodiments, the reagent warehouse 410 also includes a reagent container inlet and outlet 431 and an electric door 433 arranged at the reagent container inlet and outlet 431 in an openable and closable manner; when the electric door 433 is in an open state, it can allow the transport mechanism 490 to transport the reagent container from the reagent loading and unloading mechanism 450 to the reagent warehouse 410 through the reagent container inlet and outlet 431, or the transport mechanism 490 to transport the reagent container from the reagent warehouse 410 to the reagent loading and unloading mechanism 450 through the reagent container inlet and outlet 431; at other times, the electric door 433 can remain closed, thereby ensuring that the reagent warehouse 410 has a small heat loss and its cooling effect. That is, the electric door 433 is opened when taking or putting the reagent container from the reagent warehouse 410, and is closed at other times.

[0091] Next, the reagent loading and unloading mechanism 450 will be described.

[0092] As described above, the reagent loading and unloading mechanism 450 is used to store reagent containers to be loaded, and / or to store unloaded reagent containers, and / or to receive reagent containers to be discarded for discarding. In some specific embodiments, the reagent loading and unloading mechanism 450 is provided with a plurality of container positions, which include storage positions and discarding positions, the storage positions being used to store reagent containers to be loaded or unloaded, and the discarding positions being used to discard reagent containers to be discarded. It should be noted that the reagent containers here refer to the reagent cup 424, the first reagent container 425, and the second reagent container 426 that appear in this article, etc., which are containers that carry reagents. The reagent loading and unloading mechanism 450 has a variety of implementations, which are described in detail below.

[0093] Please refer to Fig. 9 In some embodiments, the reagent loading and unloading mechanism 450 includes a base 451 and a storage unit 460. The storage unit 460 is used to store or receive reagent containers. In some embodiments, the storage unit 460 may be fixedly disposed on the base 451, that is, the storage unit 460 is stationary - for example Fig. 9 In some other embodiments, the storage unit 460 may also be movably disposed on the base 451. For example, the reagent loading and unloading mechanism 450 further includes a driving unit 452, which is used to drive the storage unit 460 to move relative to the base 451, such as rotation or linear motion. Fig.10 This is an example in which the storage unit 460 can rotate relative to the base 451. Fig.12 This is an example in which the storage unit 460 can move linearly relative to the base 451 .

[0094] It is described above that the storage part 460 can move relative to the base 451 or can be fixed. The shape of the storage part 460 can be a disc structure or a rectangle.

[0095] For example, in some embodiments, the storage unit 460 is a disk-shaped structure. Fig. 9 and Fig.10 These are all examples of the storage unit 460 being a disk-shaped structure. The disk-shaped surface of the storage unit 460 is provided with the plurality of container positions mentioned above. As mentioned above, the plurality of container positions include a storage position 462 and a discard position 463. The storage position 462 is used to store reagent containers to be loaded or unloaded, and the discard position 463 is used to receive reagent containers to be discarded. The number of the storage positions 462 is one or more, preferably, the number of the storage positions 462 is multiple; similarly, the number of the discard position 463 is one or more, preferably, the number of the discard position 463 is one - for example Fig. 9 and Fig.10 In the example, there are ten storage positions 462 and one discarding position 463. In some embodiments, the container positions of the storage unit are arranged in a ring around the disk-shaped center of the storage unit 460. In the example where the storage unit 460 can move (e.g., rotate) relative to the base 451, when the storage unit 460 rotates, the container positions on the storage unit also rotate accordingly.

[0096] For example, in some embodiments, the storage portion 460 is rectangular—for example Fig.11 and Fig.12 This is an example. The rectangular surface of the storage unit 460 is provided with the above-mentioned plurality of container positions. Similarly, these container positions include a storage position 462 and a discard position 463. The storage position 462 is used to store reagent containers to be loaded or unloaded, and the discard position 463 is used to receive reagent containers to be discarded. The number of storage positions 462 is one or more, preferably, the number of storage positions 462 is multiple; similarly, the number of discard positions 463 is one or more, preferably, the number of discard positions 463 is one - for example Fig.11 and Fig.12 In the example shown in FIG. 4 , there are seven storage positions 462 and one discard position 463. In some embodiments, the container positions of the storage unit are arranged in a row.

[0097] The user can place the reagent container to be loaded into the storage position 462 of the storage unit 460, or take out the unloaded reagent container from the storage position 462, and the reagent container to be discarded, such as an empty reagent container with exhausted reagent, is transported from the reagent compartment 410 to the discard position 463 of the storage unit 460 to realize the discarding of the reagent container. Fig.13, the discarding position 463 can be connected to the waste box 465 through a channel 464, and the reagent container received by the discarding position 463 is discarded to the waste box 465 through the channel 464. The waste box 465 can store reagent containers such as expired reagents, empty reagent containers, etc. In the example where the storage part 460 can move relative to the base 451, when the storage part 460 moves, the channel 464 can move with the discarding position 463. For example, in the embodiment where the storage part 460 rotates relative to the base 451, the channel 464 is arranged in a manner that can rotate with the discarding position 463; in the embodiment where the storage part 460 moves linearly relative to the base 451, the channel 464 is arranged in a manner that can move linearly with the discarding position 463. In the embodiment where the channel 464 can move with the discarding position 463, this facilitates the placement position and function reuse of the waste box 465 in the sample analysis device. For example, the waste box 465 can be used to store discarded reagent containers, and can also be used to store used reaction cups.

[0098] The above is the reagent loading and unloading mechanism 450, and the transport mechanism 490 will be described below.

[0099] The transport mechanism 490 is used to transport the reagent container between the reagent warehouse 410 and the reagent loading and unloading mechanism 450. For example, the transport mechanism 490 is used to transport the reagent container to be loaded from the reagent loading and unloading mechanism 450 to the reagent warehouse 410, and / or transport the reagent container to be unloaded from the reagent warehouse 410 to the reagent loading and unloading mechanism 450, and / or transport the reagent container to be discarded from the reagent warehouse 410 to the reagent loading and unloading mechanism 450 for discarding. In combination with the storage position and the discarding position, the transport mechanism 490 is used to transport the reagent container to be loaded from the storage position of the reagent loading and unloading mechanism 450 to the reagent warehouse 410, and / or transport the reagent container to be unloaded from the reagent warehouse 410 to the storage position of the reagent loading and unloading mechanism 450, and / or transport the reagent container to be discarded from the reagent warehouse 410 to the discarding position of the reagent loading and unloading mechanism 450 for discarding. The transport mechanism 490 has multiple implementations.

[0100] Please refer to Fig.14 and Fig.15 For example, in some embodiments, the transport mechanism 450 includes a two-dimensional moving mechanism 451 and a reagent container grabbing unit 459; the two-dimensional moving mechanism 451 can drive the reagent container grabbing unit 459 to move one dimensionally between the reagent compartment 410 and the storage unit 460 (for example Fig.14 The reagent container grabbing portion 459 is driven to move in the up and down directions (for example, Fig.14The reagent container gripping portion 459 is used to grip and put down the reagent container. In the example where the transport mechanism 450 can perform one-dimensional movement in the plane direction and in the up-and-down direction, the reagent loading and unloading mechanism 450 can be a structure in which the storage unit 460 can move relative to the base 451.

[0101] For example, in some embodiments, please refer to Fig.16 The transport mechanism 450 includes a three-dimensional moving mechanism 453 and a reagent container grabbing unit 459; the three-dimensional moving mechanism 453 can drive the reagent container grabbing unit 459 to move in a three-dimensional direction; the reagent container grabbing unit 459 is used to grab and put down the reagent container. In the example where the transport mechanism 450 can perform three-dimensional movement, the reagent loading and unloading mechanism 450 can be a structure in which the storage unit 460 is fixed.

[0102] The above is the description of the reagent bin 410, the reagent loading and unloading mechanism 450 and the transport mechanism 490. The reagent bin 410, the reagent loading and unloading mechanism 450 and the transport mechanism 490 of the present application cooperate to not interrupt the test process when loading, unloading and discarding reagents. For example, the user places the reagent container to be loaded into the storage position 462 on the storage unit 460, and the transport mechanism 490 then transports the reagent container to be loaded from the storage position 462 on the storage unit 460 to the reagent warehouse 410 at an appropriate time, thereby realizing real-time loading of reagents without interrupting the test process; similarly, the transport mechanism 490 transports the reagent container to be unloaded from the reagent warehouse 410 to the storage position 462 on the storage unit 460 at an appropriate time for the user to take out, which will not affect or interrupt the normal test process of the reagent warehouse 410; similarly, the transport mechanism 490 transports the reagent container to be discarded from the reagent warehouse 410 to the discard position 463 on the storage unit 460 for discarding at an appropriate time, which will not affect or interrupt the normal test process of the reagent warehouse 410.

[0103] In some embodiments, the information reader / writer 470 can sense a label on a reagent container to read reagent information of the reagent container, and can write information to the label of the reagent container, wherein the reagent information at least includes the reagent amount or the reagent remaining amount. Fig.17 This is also an example in which a sample analysis device includes an information reader / writer 470 .

[0104] Specifically, the reagent container may be provided with a label, and the information reader / writer 470 reads the label information by sensing the label of the reagent container. The label of the reagent container stores the reagent information of the corresponding reagent, and the reagent information or label information may include the reagent type and the reagent remaining amount, etc., and may also include information such as the reagent container type, production date, shelf life, batch number, serial number, bottle opening date, and several calibration curves. The information reader / writer 470 may be an RFID reader / writer, and the label of the reagent container may be an RFID tag. The information reader / writer 470 may assist in completing the information management function of the reagent.

[0105] The controller 90 controls the information reader / writer 470 to read the reagent information of the reagent container to be loaded on the reagent loading and unloading mechanism 450; the controller 90 controls the reagent information to be written into the memory 91. Before the reagent container to be loaded is transported to the reagent warehouse 410 by the transport mechanism 490, the controller 90 controls the information reader / writer 470 to write information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable. After the controller 90 controls the transport mechanism to transport the reagent container to be loaded from the reagent loading and unloading mechanism 450 to the reagent warehouse 410, the reagent amount or the reagent remaining amount in the reagent information corresponding to the reagent container in the memory 91 can be at least updated in real time.

[0106] When the reagent container needs to be discarded, the controller 90 controls the conveying mechanism 490 to transport the reagent container to the reagent loading and unloading mechanism 450 for discarding. It can be seen that when loading the reagent container, before the reagent container is transported to the reagent warehouse 410, its label is written with information so that the reagent information corresponding to the label is set to unavailable. In this way, when the reagent container is discarded due to reasons such as the reagent in it being consumed, even if the third-party manufacturer can get the reagent container, it cannot be reused because the reagent information corresponding to the label of the reagent container is set to unavailable. In some specific embodiments, the controller 90 controls the information reader 470 to write information to the label of the reagent container so that the reagent information corresponding to the label is set to unavailable, including: the controller 90 controls the information reader 470 to write information to the label of the reagent container so that the reagent information corresponding to the label is zero.

[0107] When the reagent container needs to be unloaded, that is, when the reagent warehouse 410 carries a reagent container to be unloaded, the controller 90 controls the transport mechanism 490 to transport the reagent container from the reagent warehouse 410 to the reagent loading and unloading mechanism 450 for storage; the controller 90 obtains the latest reagent quantity of the reagent container from the memory 91, and controls the information reader / writer 470 to write the latest reagent quantity of the reagent container into its label to update the reagent quantity information in its label.

[0108] The above is a description of some structures of the reagent bin 410, the reagent loading and unloading mechanism 450, the transport mechanism 490 and the reagent container 470. The following is an example of the storage part 460 of the reagent loading and unloading mechanism 450 being a disc structure and being rotatable relative to the base 451 to explain the working process of the reagent bin 410, the reagent loading and unloading mechanism 450 and the transport mechanism 490. Fig.17 This is an example of this.

[0109] In some embodiments, the reagent bin 410 has a working time sequence cycle, each working time sequence cycle of the reagent bin 410 includes a reagent suction time period, and one or more of the working time sequence cycles of the reagent bin also includes a reagent loading time period - for example, each working time sequence cycle may include a reagent loading time period. The reagent suction time period in the working time sequence cycle of the reagent bin 410 is used for the reagent bin 410 to dispatch the reagent container it carries to the reagent suction position for the reagent dispensing component 60 to suck; the reagent loading time period in the working time sequence cycle of the reagent bin 410 is used for the reagent container to be loaded into the reagent bin 410, or the reagent container is unloaded or discarded from the reagent bin 410.

[0110] For example, when loading a reagent bottle, the controller 90 controls the transport mechanism 490 to transport the reagent container from the reagent loading and unloading mechanism 450 to the reagent bin 410, which can be done as follows:

[0111] (1) The controller 90 controls the transport mechanism 490 to transport the reagent container from the reagent loading and unloading mechanism 450 to the upper side of the preset position of the reagent chamber 410;

[0112] (2) During the reagent suction time period in the working time sequence cycle of the reagent chamber 410 , the controller 90 controls the transport mechanism 490 to place the reagent container to be loaded into the reagent chamber 410 from above the above-mentioned preset position of the reagent chamber 410 .

[0113] For another example, when unloading or discarding a reagent bottle, the controller 90 controls the transport mechanism 490 to transport the reagent container from the reagent bin 410 to the reagent loading and unloading mechanism 450, which can be done as follows:

[0114] (1) During the reagent loading period of the working time sequence cycle of the reagent compartment 410 , the controller 90 controls the transport mechanism 490 to take the reagent container out of the reagent compartment 410 ;

[0115] (2) The controller 90 controls the transport mechanism 490 to transport the removed reagent container to the reagent loading and unloading mechanism 450 .

[0116] The present invention can load reagents without stopping the test. The user directly puts the reagent container to be loaded on the empty storage position 462 of the reagent loading and unloading mechanism 450. The driving unit 452 of the reagent loading and unloading mechanism 450 drives the storage unit 460 of the disc structure to rotate, and the reagent container to be loaded is transferred to the position of the information reader 470. The information reader 470 reads the reagent information from the label of the reagent container to be loaded, for example, the reagent type, the reagent remaining amount (also referred to as the reagent loading amount or reagent amount), the reagent container type, the production date, the shelf life, the batch number, the serial number, the bottle opening date and several calibration curves. After completing the reagent information reading, writing and verification, the corresponding reagent information is stored in the memory 91 for management and real-time update of information such as its reagent remaining amount. In addition, the information reader 470 also writes information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable. The reagent loading and unloading mechanism 450 rotates the compliant reagent container to the bottom of the reagent container grabbing part 459 of the conveying mechanism 450, and the reagent container grabbing part 459 grabs the reagent container downward, and then conveys it to the reagent warehouse 410, for example, above the reagent container inlet and outlet 431, and the electric door 433 opens, and the reagent container grabbing part 459 then puts the reagent container into the reagent warehouse 410 through the reagent container inlet and outlet 431, completing the reagent loading. In the example where the reagent warehouse 410 includes two circles of reagent tracks 421, the reagent container can be placed on the inner circle of the reagent track 421 or the outer circle of the reagent track 421 according to the reagent type. It should be noted that when the reagent container grasping unit 459 transports the reagent container to the reagent bin 410, for example, above the reagent container inlet and outlet 431, a request for loading the reagent can be submitted to the test process at this time. In each working timing cycle of the reagent bin 410, a fixed time can be reserved for loading the reagent - for example, 3.4 seconds are fixedly reserved for loading the reagent in an 8-second working timing cycle; after waiting for this fixed reagent loading time period, the reagent tray 420 in the reagent bin 410 places the hollow placement position 423 of the reagent track 421 under the reagent container inlet and outlet 431 or under the reagent container grasping unit 459 at this time, the electric door 433 is in an open state, the reagent container grasping unit 459 descends and puts down the reagent container and then lifts it up, and then the electric door 433 is closed, thereby completing the reagent loading.

[0117] It can be seen that some embodiments of the present invention can remove reagents from the reagent compartment 410 without stopping the test. When the reagent is exhausted or the user actively chooses to unload the reagent, the reagent container grabbing part 459 will move to the top of the reagent container inlet and outlet 431. At this time, a request for reagent removal can be submitted to the test process. After the above-mentioned fixed reagent loading time period arrives, the reagent tray 420 in the reagent compartment 410 rotates the reagent track 421 to rotate the reagent container to be removed (for example, to be discarded or to be unloaded) to the bottom of the reagent container inlet and outlet 431 or to the bottom of the reagent container grabbing part 459 at this time, the electric door 433 is in an open state, the reagent container grabbing part 459 descends, then grabs the reagent container, and then lifts it up, and then the electric door 433 is closed. The reagent container grabbing part 459 moves the reagent container to the top of the reagent loading and unloading mechanism 450. If the reagent container is a reagent container to be unloaded, the driving unit 452 of the reagent loading and unloading mechanism 450 drives the storage unit 460 of the disc structure to rotate, and rotates the empty storage position 462 to the bottom of the reagent container grabbing unit 459, and the reagent container grabbing unit 459 then places the reagent container to be unloaded on the empty storage position 462 below it, completing the unloading of the reagent. If the reagent container is a reagent container to be discarded, the driving unit 452 of the reagent loading and unloading mechanism 450 drives the storage unit 460 of the disc structure to rotate, and rotates the discarding position 463 to the bottom of the reagent container grabbing unit 459, and the reagent container grabbing unit 459 then places the reagent container to be discarded on the discarding position 463 below it, and the reagent container will fall into the waste bin 465 along the passage 464.

[0118] It can be seen that in some of the above embodiments, a discarding position 463 is provided in the reagent loading and unloading mechanism 450. This design does not require a separate discarding position 463 to be provided in the movement direction of the reagent container grabbing portion 459, thereby ensuring that the sample analysis device is small and compact. In some of the above examples, the reagent container grabbing portion 459 can achieve all functions by only one-dimensional movement in the plane direction instead of two-dimensional movement, thereby reducing the volume and cost of the sample analysis device.

[0119] It can be seen that the sample analysis device of some embodiments can concentrate the reagent loading function, reagent unloading function, and reagent discarding function on the reagent loading and unloading mechanism 450, which ensures that the instrument is compact and reduces the material cost of the instrument. When the reagent is loaded, the information reader 470 reads the label information on the reagent container and makes a validity judgment. After success, the information is written to the label to set the bottle opening date and clear the number of available times. When the reagent is unloaded, the information reader 470 writes the actual reagent remaining amount or the number of available tests to the label of the reagent container that has been unloaded on the reagent loading and unloading mechanism 450.

[0120] In some examples, the reagent management process can also be designed around the detection of the remaining reagent in the reagent compartment 410, which is described in detail below.

[0121] The controller 90 can detect the reagent remaining amount information in each reagent container carried by the reagent warehouse 410. Specifically, when the reagent container is loaded from the reagent loading and unloading mechanism 450 to the reagent warehouse 410, the label information of the reagent container is read by the information reader 470, so that the reagent amount, reagent remaining amount or loading amount of the reagent container can be obtained, such as the test amount of 100 times. The controller 90 can therefore know the initial remaining amount when the reagent container is loaded into the reagent warehouse 410. When the reagent in the reagent container is sucked and tested once, its test amount is reduced by 1, so that the real-time reagent remaining amount information of each reagent container can be detected and titled in real time. When it is detected that there is insufficient reagent remaining amount of a reagent container in the reagent warehouse 410, the controller 90 can send a prompt message to prompt the user to put in the required reagent container; the prompt message at least includes the reagent type information of the reagent container with insufficient reagent remaining amount.

[0122] In some embodiments, when it is detected that the reagent remaining amount of a reagent container in the reagent compartment 410 is insufficient, the reagent type information of the reagent container is obtained, and the reagent container with the same reagent type information in the reagent loading and unloading mechanism 450 is determined as the reagent container to be loaded. When it is detected that the reagent remaining amount of multiple reagent containers in the reagent compartment 410 is insufficient, at least the reagent type information of the reagent container with the least reagent remaining amount among the multiple reagent containers is obtained, and the reagent container with the same reagent type information as the reagent container with the least reagent remaining amount in the reagent loading and unloading mechanism 450 is determined as the reagent container to be loaded. When determining the reagent container to be loaded from the reagent loading and unloading mechanism 450, the controller 90 can first query whether there is a reagent container with the same reagent type information in the reagent loading and unloading mechanism 450 based on the reagent type information of the reagent container with insufficient reagent remaining amount obtained - the information reader 470 can read the reagent information of each reagent container on the reagent loading and unloading mechanism 450. As mentioned above, the reagent information includes the reagent type information; if the reagent container with the same reagent type information is queried in the reagent loading and unloading mechanism 450, the controller 90 determines it as the reagent container to be loaded, otherwise, the controller 90 sends a prompt message to prompt the user to put in the required reagent container; the prompt message at least includes the reagent type information of the reagent container with insufficient reagent remaining amount. In other embodiments, the controller 90 can also determine the corresponding reagent container in the reagent loading and unloading mechanism 450 as the reagent container to be loaded when receiving the loading instruction triggered by the user. Regardless of whether it is based on the reagent remaining amount or the loading instruction triggered by the user, after the reagent container to be loaded is determined from the reagent loading and unloading mechanism 450 , the controller 90 controls the transport mechanism 490 to transport the reagent container to be loaded from the reagent loading and unloading mechanism 450 to the reagent warehouse 410 .In order to reduce the impact of reagent loading on the normal working process and testing of the reagent warehouse 410, a reagent loading time period can be set in each working timing cycle of the reagent warehouse 410. This reagent loading time period is used for reagent loading, and only when the reagent loading action needs to be coordinated with the reagent warehouse 410, the reagent warehouse 410 is controlled to perform corresponding actions in this reagent loading time period. Specifically: the controller 90 controls the conveying mechanism 490 to take out the reagent container to be loaded from the reagent loading and unloading mechanism 450, and the controller 90 controls the conveying mechanism 490 to transport the reagent container to be loaded to the top of the preset position of the reagent warehouse 410 - it can be seen , these actions can be completed independently of the reagent warehouse 410, and the reagent warehouse 410 is not affected when these actions are performed; then, during the above-mentioned reagent loading time period, the controller 90 controls the conveying mechanism 490 to place the reagent container to be loaded from above the preset position of the reagent warehouse 410 into the reagent warehouse 410. Specifically, during this reagent loading time period: the controller 90 controls the empty placement position in the reagent warehouse 410 to be dispatched to the preset position, and controls the opening of the electric door 433, and then controls the conveying mechanism 490 to place the reagent container to be loaded from above the preset position of the reagent warehouse to the empty placement position in the reagent warehouse 410, and then controls the closing of the electric door 433.

[0123] In some embodiments, when it is detected that the reagent remaining amount of a reagent container in the reagent bin 410 is zero, it means that the reagent of the reagent container is exhausted or it is an empty reagent container, then the controller 90 determines the reagent container as a reagent container to be discarded. Then the controller 90 controls the conveying mechanism 490 to transport the reagent container to be discarded from the reagent bin 410 to the reagent loading and unloading mechanism 450 for discarding. Specifically, each working sequence cycle of the reagent bin 410 includes a reagent loading time period. When there is a reagent container to be discarded, the controller 90 controls the conveying mechanism 490 to take out the corresponding reagent container from the reagent bin 410 during the reagent loading time period; then the controller 90 controls the conveying mechanism 490 to transport the reagent container to the reagent loading and unloading mechanism 450, such as its discarding position 463. It should be noted that the action of "the conveying mechanism 490 transports the reagent container to the reagent loading and unloading mechanism 450, such as its discarding position 463" can be in the reagent loading time period or in the non-reagent loading time period, and this application does not limit this.

[0124] The above is the process of discarding the empty reagent container during the test, and the process of unloading the reagent container is similar. The unloaded reagent container, which still has reagents, can be loaded into this machine or other machines to participate in the test; generally, the reagent container is unloaded from the reagent warehouse 410-the reagent residue of the reagent container is usually not zero at this time, which is mainly for loading the reagent container into other machines; in other cases, it is possible to unload the reagent container from the reagent warehouse 410 in order to recycle its reagent container itself for reuse, and the reagent residue in the reagent container is usually zero at this time. Therefore, if it is to recycle the reagent container itself for reuse, then in this case, when it is detected that the reagent container itself needs to be recycled, the reagent residue of the reagent container is zero, then the controller 90 determines the reagent container as the reagent container to be unloaded. More commonly, in some cases, the user needs to unload the reagent container whose reagent residue is not zero, and load it into other machines to participate in the test. At this time, the controller 90 can determine the corresponding reagent container in the reagent warehouse 410 as the reagent container to be unloaded according to the unloading instruction triggered by the user when it is received. After determining that it is a reagent container to be unloaded, the controller 90 controls the conveying mechanism 490 to convey the reagent container to be unloaded from the reagent compartment 410 to the reagent loading and unloading mechanism 450 for the user to take out. Specifically, each working sequence cycle of the reagent compartment 410 includes a reagent loading time period. When there is a reagent container to be unloaded, the controller 90 controls the conveying mechanism 490 to take out the corresponding reagent container from the reagent compartment 410 during the reagent loading time period; then the controller 90 controls the conveying mechanism 490 to convey the reagent container to the reagent loading and unloading mechanism 450, such as its storage position 462. It should be noted that the action of "the conveying mechanism 490 conveys the reagent container to the reagent loading and unloading mechanism 450, such as its storage position 462" can be in the reagent loading time period or in the non-reagent loading time period, and this application does not limit this. After the transport mechanism 490 transports the reagent container to be unloaded from the reagent warehouse 410 to the reagent loading and unloading mechanism 450, the controller 90 controls the information reader / writer 470 to write the reagent remaining information of the reagent container into its label to update the reagent remaining information in its label, so that when the reagent container is reloaded on this machine or other machines, its actual reagent remaining can be known through its label.

[0125] It can be seen that no matter whether the reagent container is discarded or unloaded, the reagent container is taken out from the reagent compartment 410. In order not to affect and interrupt the normal testing process of the reagent compartment 410, the present application introduces a fixed reagent loading time period in the working timing cycle when designing the working timing cycle of the reagent compartment 410. Those skilled in the art can understand that the time of each working timing cycle is the same, and the time period of the reagent loading time period in each working timing cycle is also the same. For example, in an 8-second working timing cycle, 3.4 seconds are reserved as a fixed reagent loading time period. In the non-reagent loading time period in the working timing cycle, the reagent bin 410 can dispatch the reagents required for the current test item to the corresponding reagent suction position. When the reagent bin 410 has reagent containers to be unloaded or discarded, then during the reagent loading time period: the controller 90 controls the dispatch of the corresponding reagent container in the reagent bin 410 to a preset position, controls the opening of the electric door 433, controls the transport mechanism 490 to take the reagent container out of the preset position of the reagent bin 410, and then controls the closing of the electric door 433; this series of actions can be designed to be completed within the reagent loading time period, so as not to affect and interrupt the normal testing process of the reagent bin 410.

[0126] It can be seen that the reagent bin 410 is designed to have a fixed reagent loading time period in its working timing cycle, and this reagent loading time period can be used for reagent loading, reagent unloading and reagent discarding. If there is no reagent that needs to be loaded, unloaded or discarded, then no corresponding action may be performed during this reagent loading time period; in order to reduce the disturbance to the reagent bin 410, only one of the three tasks of reagent loading, unloading and discarding may be performed during the reagent loading time period of each working timing cycle. When there are at least two tasks of reagent loading, unloading and discarding at the same time, reagent loading may generally be prioritized, followed by reagent unloading, and then reagent discarding; of course, if the current reagent bin 410 does not have an empty placement position 423 for placing the reagent container to be loaded, it is obvious that the reagent is unloaded or discarded first.

[0127] The above is a description of some structures and working processes of the reagent chamber 410, the reagent loading and unloading mechanism 450 and the transport mechanism 490. The following will continue to describe other components in the sample analysis device.

[0128] The processing unit 50 is used to receive a reaction cup carrying a sample and process the sample in the reaction cup. The sample here refers to a reaction solution composed of a sample and a reagent. There can be one or more processing units 50.

[0129] Please refer to Fig.18In some embodiments, the processing unit 50 has at least one reaction component 51 for incubating samples or specimens, and the reaction component 51 is used to carry a reaction cup and incubate the sample or specimen in the reaction cup. In some embodiments, the reaction component 51 is rectangular and has multiple reaction cup placement positions. Generally, the reaction component 51 can heat the reaction liquid or specimen in the reaction cup on each reaction cup placement position to incubate the specimen, for example, heating the specimen in the reaction cup and maintaining it at 37±0.5°C. The specific heating time and the heated temperature can be determined by the heating parameters corresponding to different test items. In some embodiments, the length direction of the reaction component 51 is set along a first direction, for example, along the Y direction in the figure.

[0130] In some embodiments, the processing unit 50 has at least one measuring component 52 for measuring the sample, and the measuring component 52 is used to carry the reaction cup and detect the sample in the reaction cup; in some embodiments, the measuring component 52 is rectangular and has multiple reaction cup placement positions. Generally, the measuring component 52 can be configured with a detection unit (not shown in the figure) for each reaction cup placement position, and each detection unit is used to detect the sample in the reaction cup at the corresponding reaction cup placement position. In some embodiments, the length direction of the measuring component 52 is set along a second direction different from the first direction, for example, it is set along the X direction in the figure.

[0131] In some embodiments, the reaction component 51 and the determination component 52 are disposed adjacently around the reagent chamber 410. In some specific embodiments, the reaction component 51 and the determination component 52 are disposed along the first side 1a and the second side 1b, respectively, and are disposed adjacently around the reagent chamber 410.

[0132] The rectangular reaction component 51 and the measuring component 52 are respectively arranged along the first side 1a and the second side 1b, and surround the reagent chamber 410 in an adjacent manner, which can save space and reduce the size of the sample analysis device. It is also beneficial for the reagent chamber 410 to interact with the reaction component 51 and the measuring component 52 through the reagent dispensing component 60.

[0133] In some embodiments, the sample injection component 20, such as the sample injection component 21, the reaction cup loading component 10, the reaction component 51 and the determination component 52 are arranged around the reagent compartment 410. The present application takes the reagent compartment 410 as the center, and designs the scheduling track of the entire detection process of the reaction cup around the reagent compartment 410, which is novel in design and saves space.

[0134] Each processing unit 50 can be configured with a corresponding reagent adding transfer position, for example, the reaction component 51 is configured with at least one incubation transfer position 51a for placing a reaction cup, and the number of incubation transfer positions 51a can be one or more; when the position of the incubation transfer position 51a for placing the reaction cup is set to 1, the incubation transfer position 51a can be set in a position-adjustable manner so that the reaction cup placed on the incubation transfer position 51a can correspond to each reagent needle in the first reagent dispensing component (the first reagent dispensing component corresponds to the reaction component and adds reagent to the reaction cup in the reaction component) to receive the reagent dispensed by each reagent needle. In some embodiments, the incubation transfer position 51a is arranged between the reagent compartment 410 and the reaction component 51. The determination component 52 is configured with at least one determination transfer position 52a for placing the reaction cup, and the number of determination transfer positions 52a can be one or more; in some embodiments, the determination transfer position 52a is arranged between the reagent compartment 410 and the determination component 52. When the position for placing the reaction cup at the measurement transfer position 52a is set to one, the measurement transfer position 52a can be set in a positionally adjustable manner so that the reaction cup placed on the measurement transfer position 52a can correspond to the positions of each reagent needle in the second reagent dispensing component (the second reagent dispensing component corresponds to the measurement component and adds reagent to the reaction cup in the measurement component) to receive the reagent dispensed by each reagent needle.

[0135] Fig.18 What is shown is that the number of incubation transfer positions 51a is one, and each incubation transfer position 51a has two reaction cup placement positions, such as the first position and the second position for placing the reaction cup; the number of measurement transfer positions 52a is one, and each measurement transfer position 52a has two reaction cup placement positions, such as the third position and the fourth position for placing the reaction cup.

[0136] The reagent dispensing component 60 is used to absorb the reagent and discharge it into the reaction cup, for example, to absorb the reagent from the reagent absorption position and discharge it into the reaction cup of the reagent addition position. For example, the reagent dispensing component 60 can absorb the first reagent from the first reagent absorption position mentioned in this article and discharge it into the reaction cup; the reagent dispensing component 60 can absorb the second reagent from the second reagent position mentioned in this article and discharge it into the reaction cup. In some embodiments, the reagent dispensing component 60 can be arranged in the housing 1.

[0137] The reagent dispensing component 60 can be implemented by a reagent needle. Therefore, in some embodiments, the reagent dispensing component 60 includes a reagent needle, which is used to absorb the reagent from the reagent chamber 410 and discharge it into the reaction cup.

[0138] From the perspective of the number of reagent needles, in some embodiments, the reagent dispensing component 60 may have multiple reagent needles, and each reagent needle is arranged in a manner that can move independently of each other. Specifically, the reagent needles can be configured as follows: each processing unit 50 is configured with a group of reagent needles; the reagent needles are used to absorb reagents from the reagent compartment 410 and discharge them into the reaction cup of the corresponding processing unit 50, and each group of reagent needles includes at least two reagent needles. For example, a group of reagent needles can be configured for the reaction component 51, and a group of reagent needles can be configured for the measurement component 52. In some specific embodiments, a first group of reagent needles can be configured for the reaction component 51, and the first group of reagent needles are arranged in a manner of linear motion between the reagent aspiration position and the incubation transfer position 51a, and the first group of reagent needles are used to aspirate reagents from the reagent aspiration position and discharge them into a reaction cup located at the incubation transfer position 51a, and the first group of reagent needles include at least one reagent needle; similarly, a second group of reagent needles can be configured for the measurement component 52, and the second group of reagent needles are arranged in a manner of linear motion between the reagent aspiration position and the measurement transfer position 52a, and the second group of reagent needles are used to aspirate reagents from the reagent aspiration position and discharge them into a reaction cup located at the measurement transfer position 52a, and the second group of reagent needles include at least one reagent needle.

[0139] From the perspective of the number of reagent dispensing components 60, in some embodiments, the number of reagent dispensing components 60 is equal to the number of processing units 50, and one reagent dispensing component 60 corresponds to one processing unit 50. Figures 1 to 3 These are all examples of this. Specifically, there may be two reagent dispensing components 60, the reaction component 51 corresponds to one of the reagent dispensing components 60, and the determination component 52 corresponds to the other reagent dispensing component 60. A reagent dispensing component 60 is configured for each processing unit 50, and the actions of the reagent adding process of the detection item are decomposed, that is, each reagent dispensing component 60 only needs to add the corresponding reagent to the reaction cup of the corresponding processing unit 50, which makes the adding of the corresponding reagent of the detection item completed by division of labor, which is conducive to improving efficiency.

[0140] Next, the specific structure of the reagent dispensing unit 60 will be described.

[0141] Please refer to Fig.19 Each reagent dispensing component 60 includes a plurality of reagent needles 61 and a guide assembly 62 for guiding the plurality of reagent needles 61 to make linear motion, and a second drive assembly 63 for driving the plurality of reagent needles 61 to make linear motion along the guide assembly 62. The guide assembly 62 is arranged along the direction determined by the reagent suction position and the reagent adding intermediate transfer position of the processing unit 50 corresponding to the reagent dispensing component 60, so that the reagent needle 61 absorbs the reagent from the reagent suction position and discharges it into the reaction cup at the reagent adding intermediate transfer position of the processing unit 50 corresponding to the reagent dispensing component 60. For example Fig.19The reagent dispensing component 60 on the left side of the middle has a guide assembly 62 arranged along the direction determined by the reagent suction position and the incubation transfer position 51a of the reaction component 51, so that the reagent needle 61 of the reagent dispensing component 60 sucks the reagent from the reagent suction position and discharges it into the reaction cup located at the incubation transfer position 51a; Fig.19 The reagent dispensing component 60 on the right side of the middle has a guide component 62 arranged along the direction determined by the reagent aspiration position and the assay transfer position 52a of the assay component 52, so that the reagent needle 61 of the reagent dispensing component 60 draws the reagent from the reagent aspiration position and discharges it into the reaction cup located at the assay transfer position 52a. In some embodiments, the number of second drive components 53 of each reagent dispensing component 60 is equal to the number of reagent needles 61, and the independent driving force output ends of the multiple second drive components 53 act on the multiple reagent needles 61 accordingly, so as to independently drive the multiple reagent needles 61 to perform linear motion along the guide component 52 between the reagent aspiration position and the reagent addition transfer position. For example Fig.19 The example shown in FIG. 6 is an example in which each reagent dispensing component 60 includes two reagent needles 61 , and each reagent needle 61 is independently driven by its own second driving assembly 63 .

[0142] There are many ways to implement the guide component 52, and a few are listed below.

[0143] Fig. 20 It is a schematic diagram of the side of the reagent dispensing component 60. In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a crossbeam 62a, and a plurality of guide members 62b arranged in parallel and along the length direction of the crossbeam 62a; the crossbeam 62a is arranged along the direction determined by the reagent suction position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are respectively slidably connected to the plurality of guide members 62b, so that the reagent needle 61 moves linearly along the guide members 62b between the reagent suction position and the reagent adding transfer position. In some embodiments, each reagent dispensing component 60 has two reagent needles 61; each reagent dispensing component 60 has two guide members 62b, and both guide members 62b are linear guides; the two linear guides are respectively arranged on both sides of the crossbeam 62a along the long axis direction of the crossbeam 62a—— Fig.21 What is shown is a schematic diagram of one side of the beam 62a, and the structure on the other side reveals a reagent needle 61; the two reagent needles 61 are respectively arranged on the linear guides on both sides of the beam 62a, and are slidably connected to the linear guides; the reagent needle 61 moves linearly between the reagent aspiration position and the reagent addition transfer position along the linear guides on which it is located.

[0144] This is an implementation method of realizing a reagent dispensing component by respectively setting a reagent needle on both sides of a beam. In other embodiments, a reagent dispensing component can also be realized by two parallel beams, each of which is only provided with a reagent needle, as described in detail below.

[0145] Please refer to Fig.21 and Fig. 22 In some embodiments, the guide assembly 62 of each reagent dispensing component 60 includes: a plurality of parallelly arranged beams 62a, and a plurality of guide members 62b respectively arranged on the plurality of the above-mentioned beams 62a and arranged along the length direction of the above-mentioned beams 62a; the plurality of the above-mentioned beams 62a are arranged along the direction determined by the reagent aspiration position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60; the number of guide members 62b is equal to the number of reagent needles 61 of the reagent dispensing component 60, and the plurality of reagent needles 61 are respectively slidably connected to the plurality of guide members 62b, so that the reagent needle 61 makes a linear motion along the guide member 62b between the reagent aspiration position and the reagent adding transfer position. In some embodiments, the multiple guide members 62b of each reagent dispensing component 60 are linear guides, and the multiple linear guides are respectively arranged along the long axis direction of the multiple beams 62a; the multiple reagent needles 61 are respectively arranged on the linear guides of the multiple beams 62a and are slidably connected to the linear guides; the reagent needles 61 perform linear motion between the reagent aspiration position and the reagent addition transfer position along the linear guides on which they are located.

[0146] In some embodiments, the crossbeam 52 a of the guide assembly 52 in each reagent dispensing component 60 is fixedly disposed above the reagent suction position and the reagent adding transfer position of the processing unit 50 corresponding to the reagent dispensing component 60 .

[0147] The reagent dispensing component 60 realizes the linear motion of multiple needles through the crossbeam structure. The movement trajectory of the reagent needle 61 does not take up too much space and minimizes the layout interference with other components, making the structure of the sample analysis device more compact, which is very beneficial to the miniaturized design of the sample analysis device.

[0148] In some embodiments, the linear motion trajectories of the reagent needles 61 of different reagent dispensing components 60 do not intersect with each other, so that the movements of the reagent needles 61 of different reagent dispensing components 60 will not be interfered with each other, which is beneficial to improving the test speed.

[0149] In some embodiments, at least one processing unit 50 has a reagent transfer position including the same number of cuvette placement positions as the reagent needles 61 of the reagent dispensing component 60 corresponding to the processing unit 50. Fig.18In the example, the reagent adding transfer position of the reaction component 51 is the incubation transfer position 51a in the figure, and the incubation transfer position 51a can hold two reaction cups; the number of reagent needles 61 of the reagent dispensing component 60 corresponding to the reaction component 51 is two. Fig.18 In the figure, the reagent adding intermediate transfer position of the measuring part 52 is the measuring intermediate transfer position 52a in the figure, and the measuring intermediate transfer position 52a can place two reaction cups; the number of reagent needles 61 of the reagent dispensing part 60 corresponding to the measuring part 52 is two. In some embodiments, the number of the reagent suction positions is the same as the number of the reagent needles. For example Fig.18 There are two reagent dispensing parts 60, each of which has two reagent needles 61, so the number of reagent suction positions is four. The number of reagent needles is the same as the number of reagent adding positions, so that each reagent needle can clearly divide the work and add reagent to the reaction cup on its own reagent adding position, which is conducive to improving the test speed.

[0150] In some embodiments, the reagent needles 61 in the same reagent dispensing component 60 are used to absorb the same type of reagent. For example, the reagent needles 61 of the reagent dispensing component 60 corresponding to the reaction component 51 are all used to absorb the first reagent, and the reagent needles 61 of the reagent dispensing component 60 corresponding to the determination component 52 are all used to absorb the second reagent. Different reagent dispensing components 60 are used to absorb different reagents, which makes the division of labor of each reagent dispensing component 60 clear, which is conducive to improving the test speed.

[0151] In some embodiments, each reagent needle 61 of the reagent dispensing component 60 is provided with a heating component (not shown in the figure) for heating the reagent sucked by the reagent needle. Since each reagent dispensing component 60 includes multiple reagent needles 61, let's take two reagent needles as an example, and each reagent needle 61 is further provided with a heating component. Since there are two reagent needles 61, each reagent needle 61 has sufficient time, for example, doubled time, to heat the sucked reagent while maintaining the original speed, so that when the reagent reaches the corresponding processing unit 50, the temperature of the reagent is already close to the predetermined temperature, that is, the reagent has been fully preheated.

[0152] The above is some description of the reagent dispensing component 60. The following may take the case where the number of processing units 50 is two, specifically the reaction component 51 and the determination component 52 as an example to explain the matching relationship and corresponding structure between the reagent dispensing component 60 and the processing unit 50.

[0153] In some embodiments, the reagent dispensing component 60 corresponding to the reaction component 51 is a first reagent dispensing component, and the reagent dispensing component 60 corresponding to the measurement component 52 is a second reagent dispensing component, which is described in detail below.

[0154] In some embodiments, the first reagent dispensing component 60 includes a first crossbeam 62a and a first group of reagent needles, and the first group of reagent needles includes at least a plurality of first reagent needles 6b, for example, two; the plurality of first reagent needles 61 are arranged on the first crossbeam 62a, and move linearly along the long axis direction of the first crossbeam 62a to absorb the first reagent from the first reagent aspirating position and discharge it into the reaction cup located at the incubation transfer position 51a. In some embodiments, the first crossbeam 62a is arranged along the direction determined by the first reagent aspirating position and the incubation transfer position 51a, and the first crossbeam 62a is fixedly arranged at the upper position corresponding to the first reagent aspirating position and the incubation transfer position 51a.

[0155] In some embodiments, the first crossbeam 62a of the first reagent dispensing component 60 is set as one, and the above-mentioned multiple first reagent needles 61 are arranged in parallel on this first crossbeam 62a, and move linearly along the long axis direction of the first crossbeam 62a. Taking the first group of reagent needles with two first reagent needles 61 as an example, a linear guide is respectively arranged on both sides of the first crossbeam 62a along its long axis direction, and the two first reagent needles 61 are respectively arranged on the linear guides on both sides of the first crossbeam 62a, and the first reagent needle 61 moves linearly between the first reagent suction position and the incubation transfer position 51a along the linear guides. This is an implementation method of realizing the first reagent dispensing component by arranging a first reagent needle on both sides of a first crossbeam.

[0156] In some embodiments, the number of first beams 62a of the first reagent dispensing component 60 is equal to the number of the first reagent needles 61 of the first group of reagent needles, and each of the first beams 62a is provided with a first reagent needle 61, and the first beams 62a are arranged parallel to each other. In some specific embodiments, a plurality of first beams 62a are provided with a linear guide along their long axis, and the plurality of first reagent needles 61 are respectively arranged on the linear guides of the plurality of first beams 62a, so that the first reagent needles 61 can move linearly between the first reagent suction position and the incubation transfer position 51a. This is an implementation method of the first reagent dispensing component by providing a plurality of, for example, two parallel first beams, with only one first reagent needle on each first beam.

[0157] In some embodiments, the first reagent dispensing component 60 also includes a plurality of driving mechanisms that independently drive the plurality of first reagent needles to perform linear motion, such as second driving components, the number of the plurality of second driving components is equal to the number of the plurality of first reagent needles, and the independent driving force output ends of the plurality of second driving components act on the plurality of first reagent needles respectively to drive the plurality of first reagent needles to perform linear motion along the long axis direction of the first beam between the first reagent aspiration position and the incubation transfer position 51a.

[0158] Take the incubation transfer position 51a in the above text as an example, which includes the first position and the second position for placing the reaction cup. Then, in the example where the first reagent dispensing component 60 has two first reagent needles 61, one of the first reagent needles 61 moves linearly along the first cross beam 62a between the first reagent aspiration position and the first position, and the other first reagent needle 61 moves linearly along the first cross beam 62a between the first reagent aspiration position and the second position.

[0159] In some embodiments, the first reagent dispensing component 60 also includes a first Z-direction drive assembly 64 for driving the first reagent needles 61 in the first group of reagent needles to move in the vertical direction, and the number of the first Z-direction drive assemblies 64 is the same as the number of the first reagent needles 61 in the first group of reagent needles; the first Z-direction drive assembly 64 includes: a first Z-direction guide 64a for guiding the first reagent needle 61 to move in the vertical direction, and a first Z-direction drive 64b for driving the first reagent needle to move along the first Z-direction guide; the first reagent needle 61 forms a sliding connection with the first crossbeam 62a through the first Z-direction guide 64a and the first Z-direction drive 64b, so that the first reagent needle 61 can move in the vertical direction relative to the first crossbeam 62a under the drive of the first Z-direction drive 64b. It can be understood by those skilled in the art that when the reagent needle performs reciprocating linear motion, it needs to move in the vertical direction when reaching each position to complete operations such as absorbing and discharging reagents.

[0160] In some embodiments, the first reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent sucked therein.

[0161] The above is some description about the first reagent dispensing part 60, and the second reagent dispensing part 60 will be described below.

[0162] The second reagent dispensing component 60 includes a second crossbeam 62a and a second group of reagent needles, and the second group of reagent needles includes at least a plurality of second reagent needles 61, for example, two; the plurality of second reagent needles 61 are arranged on the second crossbeam 62a, and move linearly along the long axis direction of the second crossbeam 62a to absorb the second reagent from the second reagent aspirating position and discharge it into the reaction cup located at the measurement transfer position 52a. In some embodiments, the second crossbeam 62a is arranged along the direction determined by the second reagent aspirating position and the measurement transfer position 52a, and the second crossbeam 62a is fixedly arranged at the upper position corresponding to the second reagent aspirating position and the measurement transfer position 52a.

[0163] In some embodiments, the second crossbeam 62a of the second reagent dispensing component 60 is provided as one, and the above-mentioned multiple second reagent needles 61 are arranged in parallel on this second crossbeam 62a, and move linearly along the long axis direction of the second crossbeam 62a. Taking the second group of reagent needles having two first reagent needles 61 as an example, a linear guide is respectively arranged on both sides of the second crossbeam 62a along its long axis direction, and the two second reagent needles 61 are respectively arranged on the linear guides on both sides of the second crossbeam 62a, and the second reagent needle 61 moves linearly between the second reagent suction position and the measurement transfer position 52a along the linear guides where it is located. This is an implementation method of realizing the second reagent dispensing component by arranging a second reagent needle on both sides of a second crossbeam.

[0164] In some embodiments, the number of second beams 62a of the second reagent dispensing component 60 is equal to the number of the second reagent needles 61 of the second group of reagent needles, and each of the second beams 62a is provided with a second reagent needle 61, and the second beams 62a are arranged parallel to each other. In some specific embodiments, the plurality of second beams 62a are provided with a linear guide along their long axis direction, and the plurality of second reagent needles 61 are respectively arranged on the linear guides of the plurality of second beams 62a, so that the second reagent needles 61 can move linearly between the second reagent suction position and the measurement transfer position 52a. This is an implementation method of the second reagent dispensing component by means of a plurality of, for example, two parallel second beams, each of which is provided with only one second reagent needle.

[0165] In some embodiments, the second reagent dispensing component 60 further includes a plurality of drive mechanisms that are different from the second drive assembly and independently drive the plurality of second reagent needles to perform linear motion, such as third drive assemblies, the number of the third drive assemblies is equal to the number of the plurality of second reagent needles, and the plurality of third drive assemblies have independent driving force output ends that act on the plurality of second reagent needles, respectively, to drive the plurality of second reagent needles to perform linear motion between the second reagent position and the measurement transfer position along the long axis direction of the second crossbeam. The second drive assembly and the third drive assembly may have the same structure.

[0166] Take the example that the transfer position 52a in the above determination includes the third position and the fourth position for placing the reaction cup. Then, in the example where the second reagent dispensing component 60 has two second reagent needles 61, one of the second reagent needles 61 moves linearly along the second cross beam 62a between the second reagent aspiration position and the third position, and the other second reagent needle 61 moves linearly along the second cross beam 62a between the second reagent aspiration position and the fourth position.

[0167] In some embodiments, the second reagent dispensing component 60 also includes a second Z-direction drive assembly 64 for driving the second reagent needles 61 in the second group of reagent needles to move in the vertical direction, and the number of the second Z-direction drive assemblies 64 is the same as the number of the second reagent needles 61 in the second group of reagent needles; the second Z-direction drive assemblies 64 include: a second Z-direction guide 64a for guiding the second reagent needle 61 to move in the vertical direction, and a second Z-direction drive 64b for driving the second reagent needle 61 to move along the second Z-direction guide 64a; the second reagent needle 61 forms a sliding connection with the second beam 62a through the second Z-direction guide 64a and the second Z-direction drive 64b, so that the second reagent needle 61 can move in the vertical direction relative to the second beam 62a under the drive of the second Z-direction drive 64b.

[0168] In some embodiments, the second reagent needle 61 may also be provided with a heating component (not shown in the figure) for heating the reagent absorbed by it.

[0169] In some embodiments, the linear motion trajectory of the multiple first reagent needles 61 of the first reagent dispensing component 60 between the first reagent aspiration position and the incubation transfer position 51a is the first motion trajectory; the linear motion trajectory of the multiple second reagent needles 61 of the second reagent dispensing component 60 between the second reagent aspiration position and the measurement transfer position 52a is the second motion trajectory; wherein the first motion trajectory does not intersect with the second motion trajectory.

[0170] The structures of the first reagent dispensing component 60 and the second reagent dispensing component 60 can be the same, but they are set in different directions. The first reagent dispensing component 60 is set in the direction of the reaction component 51 for cooperating with the reaction component 51, and the second reagent dispensing component 60 is set in the direction of the measuring component 52 for cooperating with the measuring component 52.

[0171] The above is some description of the reagent dispensing component 60. The reagent dispensing component 60 uses a crossbeam structure to make the reagent needle 61 continuously reciprocate between the reagent suction position of the reagent chamber 410 and the reagent adding position of the corresponding processing unit to complete the suction and discharge of the corresponding reagent.

[0172] The movements of different reagent dispensing components 60 are independent and do not interfere with each other, thus playing a significant role in miniaturizing the space of the instrument and improving the test speed.

[0173] The scheduling component 70 is used to schedule the cuvettes. For example, the scheduling component 70 schedules the cuvettes that have been loaded with samples and are located in the sample loading position to the processing units 50 according to the detection process. For example, the scheduling component 70 schedules the cuvettes that have been loaded with reagents, such as the first reagent, at the incubation transfer position 51a to the reaction component 51, and schedules the cuvettes that have been loaded with reagents, such as the second reagent, at the measurement transfer position 52a to the measurement component 52. The specific structure of the scheduling component 70 is described below.

[0174] Please refer to Fig.23In some embodiments, the scheduling component 70 includes a first transport component 71, a second transport component 73, and a third transport component 75. In order to cooperate with the three transport components 71, 73, and 75, in some embodiments, the sample analysis device is also provided with a first cache transfer position 77 and a second cache transfer position 78. In some embodiments, the first cache transfer position 77 can adopt a fixed cache position design, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is conducive to reducing the volume and size of the sample analysis device; similarly, the first cache transfer position 78 can adopt a fixed cache position design, with only one reaction cup placement position, that is, only one reaction cup can be placed, which is conducive to reducing the volume and size of the sample analysis device. Of course, in some embodiments, the first cache transfer position 77 and the second cache transfer position 78 can also be designed to have multiple reaction cup placement positions when adopting a fixed cache position design, so that there are more reaction cup placement positions in scheduling. Even in some embodiments, the first cache transfer position 77 can be designed as a movable or rotatable cache position. For example, the first cache transfer position 77 can include a cuvette placement position that can be driven to move or rotate. In this way, when the first transfer component 71 transfers the cuvette to the first cache transfer position 77, the first cache transfer position 77 can also be controlled to move or rotate to a predetermined position to receive the cuvette transferred by the first transfer component 71. In addition, when the second transfer component 73 needs to transfer the cuvette on the first cache transfer position 77, the first cache transfer position 77 can also be controlled to move or rotate to a predetermined position to enable the second transfer component 73 to grab the cuvette on the first cache transfer position 77 more quickly. The transfer position 78 may include a reaction cup placement position that can be driven to move or rotate, so that in the process of the second transfer component 73 transferring the reaction cup to the second cache transfer position 78, the second cache transfer position 78 can also be controlled to move or rotate to a predetermined position to receive the reaction cup transferred by the second transfer component 73. In addition, when the third transfer component 73 needs to transfer the reaction cup on the second cache transfer position 78, the second cache transfer position 78 can also be controlled to move or rotate to a predetermined position so that the third transfer component 75 can grab the reaction cup on the second cache transfer position 78 more quickly; through such a design, the entire transfer process of the reaction cup can be made faster and less time-consuming, thereby improving the efficiency and testing speed of the sample analysis device.

[0175] There are many specific implementation methods of the first transfer component 71, the second transfer component 73 and the third transfer component 75, such as a rail-type transfer component, which transfers the reaction cup by placing the reaction cup on the rail; another example is a turntable-type transfer component, which places the reaction cup on a turntable-type structure and transfers the reaction cup carried by the turntable to the corresponding position through the transfer of the turntable itself; for example, the first transfer component 71, the second transfer component 73 and the third transfer component 75 are implemented by driving a cup grabbing hand through a two-dimensional or three-dimensional driving mechanism, the reaction cup is grabbed by the cup grabbing hand, and then the cup grabbing hand is driven to move by a two-dimensional or three-dimensional driving mechanism, so as to realize the transfer of the reaction cup to the corresponding position. The following is an explanation of the method of implementing the transfer component by using a cup grabbing hand.

[0176] The various transfer components and their functions are described below.

[0177] The first transport component 71 is used to transport the reaction cup after sample loading to the first buffer transfer position 77. In some embodiments, the first transport component 71 moves linearly along a first direction, such as the Y direction in the figure, to transport the reaction cup after sample loading to the first buffer transfer position 77. Since the first transport component 71 moves the reaction cup in a linear motion, the volume of the sample analysis device occupied during the reaction cup transportation process is relatively reduced, which is conducive to the miniaturization design of the sample analysis device.

[0178] Please refer to Fig.24 In some embodiments, the sample analysis device may further be provided with a sample adding position 10a, a pre-dilution position 10b, a first cup throwing position 10c and a second cup throwing position 10d. In some embodiments, the first transport component 71 may move along a first direction, such as the Y direction in the figure, between the sample adding position 10a, the pre-dilution position 10b, the first cup throwing position 10c and the first cache transfer position 77. The sample adding position 10a may be a predetermined position where the reaction cup loading component 10 mentioned above loads an empty reaction cup. Generally, the sample dispensing component 30 sucks the sample from the sample suction position and discharges it into the reaction cup located at the sample adding position 10a to complete the sample addition. In some cases, the sample needs to be pre-diluted. Therefore, in this case, the first transport component 71 first transports the empty reaction cup on the sample adding position 10a to the pre-dilution position 10b, and the sample dispensing component 30 absorbs the sample from the sample suction position and discharges it into the reaction cup at the pre-dilution position 10b, and then dilutes the sample in the reaction cup at the pre-dilution position 10b; in this process, the reaction cup loading component 10 loads a new empty reaction cup onto the sample adding position 10a, and then the sample dispensing component 30 absorbs the pre-diluted sample from the reaction cup on the pre-dilution position 10b and discharges it into the sample adding position 10a, thereby completing the sample addition; the first transport component 71 then performs a cup throwing process on the reaction cup on the pre-dilution position 10b, for example, transports it to the first cup throwing position 10c for cup throwing.

[0179] As described above, in some embodiments, the first transport component 71 only needs to move along the first direction, so the driving component of the first transport component 71 can be a two-dimensional driving component, which is used to drive the cup gripper of the first transport component 71 to move along the first direction and the vertical direction, wherein the first direction can be the Y direction in the figure, and the vertical direction is the direction perpendicular to the paper surface in the figure. In some embodiments, the cup gripper of the first transport component 71 grabs the reaction cup on the sample loading position 10a along the second direction, such as the X direction in the figure, so that the first transport component 71 will not affect the sample dispensing component 30 from discharging the sample into the reaction cup when grabbing the reaction cup, so that the sample dispensing component 30 can complete the sample loading of the reaction cup while the first transport component 71 grabs the reaction cup, saving time and improving the measurement speed and efficiency.

[0180] The above is some description of the first transfer component 71.

[0181] The second transport component 73 is used to transport the cuvette in the first cache transfer position 77 to the reaction component 51, and to transport the cuvette in the reaction component 51 after the sample incubation is completed to the second cache transfer position 78. In some embodiments, the second transport component 73 transports the cuvette in the first cache transfer position 77 to the reaction component 51, and transports the cuvette in the reaction component 51 after the sample incubation is completed to the second cache transfer position 78 by linear motion along a first direction, such as the direction in the figure, and a second direction, such as the X direction in the figure. Since the second transport component 73 moves the cuvette in a linear motion, the volume of the sample analysis device occupied during the transportation of the cuvette is relatively reduced, which is conducive to the miniaturization design of the sample analysis device.

[0182] During the specific transportation process, the second transportation component 73 can first transport the reaction cup of the first cache transfer position 77 to the incubation transfer position 51a, the reagent dispensing component 60 absorbs the reagent and discharges it into the reaction cup located at the incubation transfer position 51a, and the second transportation component 73 then transports the reaction cup of the incubation transfer position 51a to the reaction component 51.

[0183] In some embodiments, the second transfer component 73 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., a direction perpendicular to the drawing), so the driving component of the second transfer component 73 can be a three-dimensional driving component, which is used to drive the cup gripper of the second transfer component 73 to move along the first direction, the second direction, and the vertical direction.

[0184] In some embodiments, the cup gripper of the second transport component 73 grabs the reaction cup along the second direction, such as the X direction in the figure, so that the second transport component 71 will not affect the reagent dispensing component 60, such as the first reagent dispensing component, when grabbing the reaction cup. The reagent dispensing component 60 can complete the addition of reagent to the reaction cup while the second transport component 73 grabs the reaction cup, saving time and improving the measurement speed and efficiency. In some embodiments, the direction in which the second transport component 73 grabs the reaction cup is greater than 90 degrees from the direction of the linear motion of the first group of reagent needles. In this case, the action of the second transport component 73 grabbing the reaction cup and the action of the first group of reagent needles adding reagents are less likely to conflict, and the two can perform corresponding actions independently and in parallel in a very reasonable manner.

[0185] In some embodiments, the second transport component 73 also mixes the sample in the reaction cup during the process of transporting the reaction cup from the incubation transfer position 51a to the reaction component 51. For example, after the second transport component 73 transports the reaction cup with sample addition from the first buffer transfer position 77 and places it in the incubation transfer position 51a, the reagent dispensing component 60 then adds reagents, such as the first reagent, to the reaction cup on the incubation transfer position 51a, and the second transport component 73 picks up the reaction cup with reagent addition, mixes it, and then transports it to the reaction component 51; specifically, the second transport component 73 can drive the cup gripper to shake quickly through the driving component 71b to achieve mixing of the sample in the reaction cup grabbed by the cup gripper. The second transport component 73 also has a mixing function, so that the sample analysis device does not need to be provided with an independent mixing mechanism, making the sample analysis device more compact and reducing costs; in addition, the second transport component 73 mixes when grabbing the reaction cup for transportation, which also saves time, and there is no need to specially dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0186] The above is some description of the second transport component 73. The second transport component 73 can and realizes the transport of reaction cups between the first cache transfer position 77, the incubation transfer position 51a, the reaction component 51 and the second cache transfer position 78 by linear motion along the first direction and the second direction.

[0187] The third transport component 75 is used to transport the cuvette in the second buffer transfer position 78 to the measuring component 52. In some embodiments, the third transport component 75 transports the cuvette in the second buffer transfer position 78 to the measuring component 52 by linear motion along a first direction, such as the direction in the figure, and a second direction, such as the X direction in the figure. Since the third transport component 75 moves the cuvette in a linear motion, the volume of the sample analysis device occupied during the cuvette transportation process is relatively reduced, which is conducive to the miniaturization design of the sample analysis device.

[0188] During the specific transportation process, the third transport component 75 may first transport the cuvette in the second buffer transfer position 78 to the measurement transfer position 52a, the reagent dispensing component 60 absorbs the reagent and discharges it into the cuvette located in the measurement transfer position 52a, and the third transport component 75 then transports the cuvette in the measurement transfer position 75a to the measurement component 52. In some embodiments, when the third transport component 75 transports the cuvette from the second buffer transfer position 78 to the measurement transfer position 52a, the third transport component 75 may not place the cuvette in the measurement transfer position 52a, but still grasp the cuvette. In this case, the reagent dispensing component 60 absorbs the reagent and discharges it into the cuvette, which reduces the time it takes for the cuvette to finally enter the measurement component 52 from the second buffer transfer position 78, thereby improving the test speed. In some embodiments, the third transfer component 75 can move along a first direction (e.g., the Y direction in the figure), a second direction (e.g., the X direction in the figure), and a vertical direction (e.g., a direction perpendicular to the drawing), so the driving component of the third transfer component 75 can be a three-dimensional driving component, which is used to drive the cup gripping hand of the third transfer component 75 to move along the first direction, the second direction, and the vertical direction.

[0189] In some embodiments, the cup gripper of the third transport component 75 grabs the reaction cup along a first direction, such as the Y direction in the figure, so that when the third transport component 75 grabs the reaction cup - even if the third transport component 75 grabs the reaction cup during the entire reagent adding process, it will not affect the reagent dispensing component 60, such as the second reagent dispensing component, adding reagent to the reaction cup, so that the reagent dispensing component 60 can complete the reagent addition to the reaction cup while the third transport component 75 grabs the reaction cup, saving time and improving the measurement speed and efficiency. In some embodiments, the direction in which the third transport component 75 grabs the reaction cup is greater than 90 degrees from the direction of the linear motion of the second group of reagent needles. In this case, the action of the third transport component 75 grabbing the reaction cup and the action of the second group of reagent needles adding reagents are less likely to conflict, and the two can perform corresponding actions independently and in parallel in a very reasonable manner.

[0190] In some embodiments, the third transport component 75 mixes the sample in the reaction cup during the process of transporting the reaction cup from the measurement transfer position 52a to the measurement component 52. For example, when the third transport component 75 transports the reaction cup from the second buffer transfer position 78 to the measurement transfer position 52a - in some embodiments, the third transport component 75 may not put down the reaction cup when transporting the reaction cup to the measurement transfer position 52a, but still grasps the reaction cup; the reagent dispensing component 60 then adds reagents such as the second reagent to the reaction cup at the measurement transfer position 52a, and the third transport component 75 mixes the sample in the grabbed reaction cup and then transports it to the measurement component 52; specifically, the third transport component 75 can drive the cup gripper to shake quickly through the driving component 71b to achieve mixing of the sample in the reaction cup gripped by the cup gripper. The third transport component 75 also has a mixing function, so that the sample analysis device does not need to be equipped with an independent mixing mechanism, making the sample analysis device more compact and reducing costs. In addition, the third transport component 75 mixes the reaction cup on the original transport path, such as at the transfer position 52a during measurement, which saves time and eliminates the need to specifically dispatch the reaction cup to the corresponding mixing mechanism for mixing.

[0191] In some examples, after dispatching the reaction cup to the measuring component 52, the third transport component 75 can also grab the reaction cup that has been measured in the measuring component 52, and then transport it to the second cup throwing position 10d for cup throwing processing. In some embodiments, the second cup throwing position 10d can be set near the second cache transfer position 78, or between the measuring component 52 and the second cache transfer position 78. In this way, when the third transport component 75 transfers the reaction cup on the second cache transfer position 78 from the measuring component 52 to the second cache transfer position 78, it can also throw the reaction cup on the measuring component 52 that has been measured, thereby saving time and improving test efficiency.

[0192] The above is some description of the third transport component 75. The third transport component 75 can realize the transport of the reaction cup between the second buffer transfer position 78, the measurement transfer position 52a, the measurement component 52 and even the second cup throwing position 10d by linear movement along the first direction and the second direction.

[0193] The above is the description of the scheduling component 70 of some embodiments of the present invention. The present application uses three transfer components, namely the first transfer component 71, the second transfer component 73 and the third transfer component 75 to complete the rapid transfer of the reaction cup. The scheduling path of the reaction cup is simple and direct, which is conducive to speeding up the sample analysis device; and cooperates with two cache transfer positions, namely the first cache transfer position 77 and the second cache transfer position 78 to complete the transition between the three transfer components, and the structure is also simple and compact.

[0194] Some specific working processes of the sample analysis device are described below.

[0195] The sample analysis device in some embodiments may work as follows.

[0196] The reaction cup loading part 10 supplies and carries empty reaction cups. For example, the reaction cup loading part 10 can load the empty reaction cup to a predetermined position, which can be used as a sample adding position. The sample injection part 20, such as the sample injection part 21, dispatches the sample rack carrying the sample to the sample suction position. The sample dispensing part 30 draws the sample from the sample suction position and dispenses it into the reaction cup, for example, the sample dispensing part draws the sample from the sample suction position and then discharges it into the reaction cup located at the sample adding position to complete the sample addition.

[0197] The driving component of the reagent carrying component 60 drives the reagent carrying component 60 to rotate so that the reagent container carrying the first reagent is located at the first reagent suction position. At least one of the two reagent needles 61 on the first reagent dispensing component 60 absorbs the first reagent in the reagent container through the first reagent suction position, and makes a linear motion between the first reagent suction position and the reagent adding transfer position of the reaction component 51 to dispense the first reagent into the reaction cup at the reagent adding transfer position of the reaction component 51. The reagent adding transfer position of the reaction component 51 can be the incubation transfer position 51a mentioned in this article. In some embodiments, the two first reagent needles 61 of the first reagent dispensing component 60 independently make a linear motion between the first reagent suction position and the reagent adding transfer position of the reaction component 51. In this way, the two first reagent needles 61 of the first reagent dispensing component 60 can separately and independently - for example, alternately complete the operation of adding the first reagent to the reaction cup on the reagent adding transfer position of the reaction component 51, thereby improving the test speed and efficiency. In some specific embodiments, each first reagent needle 61 in the first reagent dispensing component 60 performs multiple preset actions in sequence to complete the operation of adding the first reagent, and among the multiple preset actions between the two first reagent needles 61, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles 61 of the first reagent dispensing component 60 can avoid occupying as few public resources as possible, so that the number of components providing corresponding public resources can be reduced, so that the sample analysis device can be more compact; and arranging the action timing of the two first reagent needles 61 in this way also avoids mutual influence between them as much as possible, which is very beneficial to speeding up the sample analysis device.

[0198] The scheduling component 70 schedules the reaction cup after the first reagent is dispensed to the reaction component 51 for incubation, and schedules the reaction cup after the incubation to the reagent transfer position of the measurement component 52. The reagent transfer position of the measurement component 52 can be the measurement transfer position 52a mentioned herein.

[0199] The reagent disk 420 of the reagent bin 410 rotates so that the reagent container carrying the second reagent is located at the second reagent suction position. At least one of the two reagent needles on the second reagent dispensing component 60 absorbs the second reagent in the reagent container through the second reagent suction position, and makes a linear motion between the second reagent suction position and the reagent adding transfer position of the measuring component to dispense the second reagent to the reaction cup at the reagent adding transfer position of the measuring component 52. In some embodiments, the two second reagent needles 61 of the second reagent dispensing component 60 move linearly between the second reagent suction position and the reagent adding transfer position of the measuring component 52 independently of each other. In this way, the two second reagent needles 61 of the second reagent dispensing component 60 can respectively and independently - for example, alternately complete the operation of adding the second reagent to the reaction cup on the reagent adding transfer position of the measuring component 52, thereby improving the test speed and efficiency. In some specific embodiments, each second reagent needle 61 in the second reagent dispensing component 60 performs multiple preset actions in sequence to complete the operation of adding the second reagent, and among the multiple preset actions between the two second reagent needles 61, at least one corresponding preset action does not overlap in timing. In this way, the two reagent needles 61 of the second reagent dispensing component 60 can avoid occupying public resources as little as possible, so that the number of components providing corresponding public resources can be reduced, and the sample analysis device can be more compact; and arranging the action timing of the two second reagent needles in this way also avoids mutual influence between them as much as possible, which is very beneficial to speeding up the sample analysis device.

[0200] The scheduling component 70 schedules the reaction cup after the second reagent is dispensed to the measuring component 52 for item detection, and schedules the reaction cup after the detection to the waste recovery device, such as the second cup disposal position mentioned in this article.

[0201] The above is some description of the sample analysis device of the present invention. Some embodiments of the present invention also disclose a sample analysis method. Fig.25 , the sample analysis method in some embodiments comprises the following steps:

[0202] Step 1000: Control the dispatching of the sample to be tested to the sample suction position.

[0203] Step 1100: Control the reagent compartment to dispatch the reagent container it carries to the reagent suction position.

[0204] Step 1200: Control the aspiration and discharge of samples from the sample aspiration position and the aspiration and discharge of reagents from the reagent aspiration position to prepare the test sample.

[0205] Step 1300: Control the measurement of the prepared sample to obtain the test result.

[0206] In the above process, reagents are constantly consumed, so it is necessary to load reagents in real time. When the reagent loading and unloading mechanism carries a reagent container to be loaded, step 2000 controls an information reader to read the label of the reagent container to read the reagent information of the reagent container; step 2100 controls the reagent information read to be written into a memory; step 2200 controls the information reader to write information to the label of the reagent container before the reagent container to be loaded is transported to the reagent warehouse by the transport mechanism, so that the reagent information corresponding to the label is set to be unavailable. It can be understood that the order of step 2100 and step 2200 can be adjusted. Step 2300 controls the transport mechanism to transport the reagent container to be loaded from the reagent loading and unloading mechanism to the reagent warehouse; step 2400, after the transport mechanism is controlled to transport the reagent container to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, at least the reagent amount in the reagent information corresponding to the reagent container in the memory is updated in real time. Step 2500: When the reagent container needs to be discarded, the transport mechanism is controlled to transport the reagent container to the reagent loading and unloading mechanism for disposal.

[0207] It can be seen that when the reagent container is loaded, before it is transported to the reagent warehouse 410, its label is written with information so that the reagent information corresponding to the label is set to unavailable. In this way, when the reagent container is discarded due to the consumption of the reagent inside, even if the third-party manufacturer can get the reagent container, it cannot be reused because the reagent information corresponding to the label of the reagent container is set to unavailable. In some specific embodiments, step 2200 controls the information reader to write information to the label of the reagent container so that the reagent information corresponding to the label is set to unavailable, including: controlling the information reader to write information to the label of the reagent container so that the reagent information corresponding to the label is zero.

[0208] Please refer to Fig.26 When the reagent container needs to be unloaded, that is, when the reagent warehouse 410 carries a reagent container to be unloaded, step 3000, controls the transport mechanism to transport the reagent container from the reagent warehouse to the reagent loading and unloading mechanism for storage; step 3100, controls obtaining the latest reagent quantity of the reagent container from the memory 91; step 3200, controls the information reader / writer 470 to write the latest reagent quantity of the reagent container into its label to update the reagent quantity information in its label.

[0209] In some embodiments, the reagent bin 410 has a working time sequence cycle, each working time sequence cycle of the reagent bin 410 includes a reagent suction time period, and one or more of the working time sequence cycles of the reagent bin also includes a reagent loading time period - for example, each working time sequence cycle may include a reagent loading time period. The reagent suction time period in the working time sequence cycle of the reagent bin 410 is used for the reagent bin 410 to dispatch the reagent container it carries to the reagent suction position for the reagent dispensing component 60 to suck; the reagent loading time period in the working time sequence cycle of the reagent bin 410 is used for the reagent container to be loaded into the reagent bin 410, or the reagent container is unloaded or discarded from the reagent bin 410.

[0210] For example, when loading a reagent bottle, controlling the transport mechanism to transport the reagent container from the reagent loading and unloading mechanism to the reagent bin can be performed as follows:

[0211] (1) Controlling the transport mechanism 490 to transport the reagent container from the reagent loading and unloading mechanism 450 to above a preset position of the reagent chamber 410;

[0212] (2) During the reagent suction time period in the working time sequence cycle of the reagent chamber 410 , the transport mechanism 490 is controlled to place the reagent container to be loaded into the reagent chamber 410 from above the above-mentioned preset position of the reagent chamber 410 .

[0213] For another example, when unloading or discarding a reagent bottle, controlling the transport mechanism 490 to transport the reagent container from the reagent bin 410 to the reagent loading and unloading mechanism 450 can be performed as follows:

[0214] (1) During the reagent loading period of the working time sequence cycle of the reagent compartment 410 , the transport mechanism 490 is controlled to take the reagent container out of the reagent compartment 410 ;

[0215] (2) The transport mechanism 490 is controlled to transport the removed reagent container to the reagent loading and unloading mechanism 450 .

[0216] This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope of this document. For example, various operating steps and components for performing the operating steps may be implemented in different ways (e.g., one or more steps may be deleted, modified, or combined into other steps) depending on the specific application or considering any number of cost functions associated with the operation of the system.

[0217] Although the principles of this invention have been shown in various embodiments, many modifications of structures, arrangements, proportions, elements, materials and components particularly suitable for specific environments and operational requirements can be used without departing from the principles and scope of this invention. The above modifications and other changes or amendments will be included in the scope of this invention.

[0218] The foregoing specific description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of the present disclosure. Therefore, the consideration of the present disclosure will be illustrative rather than restrictive, and all these modifications will be included in its scope. Similarly, the advantages, other advantages and solutions to the problems of various embodiments have been described above. However, the benefits, advantages, solutions to the problems and any elements that can produce these, or make them more clear, should not be interpreted as critical, necessary or necessary. The term "include" and any other variants used in this article are all non-exclusive inclusions, so that the process, method, article or device including the list of elements not only includes these elements, but also includes other elements that are not explicitly listed or do not belong to the process, method, system, article or device. In addition, the term "coupled" and any other variants used in this article refer to physical connections, electrical connections, magnetic connections, optical connections, communication connections, functional connections and / or any other connections.

[0219] Those skilled in the art will appreciate that many changes may be made to the details of the above-described embodiments without departing from the basic principles of the invention. Therefore, the scope of the present invention should be determined solely by the claims.

Claims

1. A sample analysis device, characterized in that: include: A reaction cup loading component, used for supplying and carrying empty reaction cups; A scheduling component, used for scheduling reaction cups; A sampling component, used for scheduling samples to be injected; The sample dispensing component is used to absorb the sample to be injected and discharge it into the reaction cup; The reagent bin includes a placement position for carrying a reagent container; the reagent bin is used to dispatch the carried reagent container to the reagent suction position; Reagent dispensing component, used to absorb the reagent and discharge it into the reaction cup; A reagent loading and unloading mechanism, used for carrying reagent containers to be loaded and unloaded reagent containers, and receiving reagent containers to be discarded; A transport mechanism, used to transport reagent containers between the reagent warehouse and the reagent loading and unloading mechanism; the transport mechanism is used to transport reagent containers to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, and to transport reagent containers to be unloaded or discarded from the reagent warehouse to the reagent loading and unloading mechanism; One or more processing units; the processing units are used to receive the reaction cup carrying the sample or the sample prepared by the sample and the reagent dispatched by the dispatching component, and process the liquid in the reaction cup; An information reader / writer, capable of sensing a label on a reagent container to read reagent information of the reagent container, and capable of writing information to the label of the reagent container; The reagent information at least includes the reagent amount; Memory and controller; in: The controller controls the information reader to read the reagent information of the reagent container to be loaded on the reagent loading and unloading mechanism; the controller controls the reagent information to be written into the memory; before the reagent container to be loaded is transported to the reagent warehouse by the transport mechanism, the controller controls the information reader to write information to the label of the reagent container, so that the reagent information corresponding to the label is set to be unavailable; The controller is used to control the transport mechanism to transport the reagent container to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, and at least update the reagent quantity in the reagent information corresponding to the reagent container in the memory in real time; when the reagent container needs to be discarded, the controller controls the transport mechanism to transport the reagent container to the reagent loading and unloading mechanism for discarding.

2. The sample analysis device according to claim 1, wherein: The controller controls the information reader to write information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable, including: The controller controls the information reader / writer to write information to the label of the reagent container so that the reagent information corresponding to the label is zero.

3. The sample analysis device according to claim 1, wherein: When the reagent bin carries a reagent container to be unloaded, the controller controls the transport mechanism to transport the reagent container from the reagent bin to the reagent loading and unloading mechanism for storage; the controller obtains the latest reagent quantity of the reagent container from the memory, and controls the information reader to write the latest reagent quantity of the reagent container into its label to update the reagent quantity information in its label.

4. The sample analysis device according to any one of claims 1 to 3, wherein the reagent chamber has a working time sequence cycle, each working time sequence cycle of the reagent chamber includes a reagent suction time period, and one or more of the working time sequence cycles of the reagent chamber also includes a reagent loading time period; The reagent suction time period in the working time sequence cycle of the reagent warehouse is used for the reagent warehouse to dispatch the reagent container it carries to the reagent suction position for the reagent dispensing component to suck; The reagent loading time period in the working timing cycle of the reagent chamber is used for loading reagent containers into the reagent chamber, or for unloading or discarding reagent containers from the reagent chamber.

5. The sample analysis device according to claim 4, characterized in that: The controller controls the transport mechanism to transport the reagent container from the reagent loading and unloading mechanism to the reagent bin, including: The controller controls the transport mechanism to transport the reagent container from the reagent loading and unloading mechanism to above a preset position of the reagent bin; During the reagent suction time period in the working time sequence cycle of the reagent bin, the controller controls the conveying mechanism to place the reagent container to be loaded into the reagent bin from above a preset position of the reagent bin.

6. The sample analysis device according to claim 4, characterized in that: The controller controls the transport mechanism to transport the reagent container from the reagent bin to the reagent loading and unloading mechanism, including: During the reagent loading time period in the working time sequence cycle of the reagent bin, the controller controls the transport mechanism to take the reagent container out of the reagent bin; The controller then controls the transport mechanism to transport the removed reagent container to the reagent loading and unloading mechanism.

7. A sample analysis method, characterized in that: include: Control the dispatching of samples to be tested to the sample suction position; Control the reagent compartment to dispatch the reagent container to the reagent suction position Controlling the aspiration and discharge of the sample from the sample aspiration position and the aspiration and discharge of the reagent from the reagent aspiration position to prepare the test sample; Controlling the measurement of the prepared sample to obtain the test result; in: When the reagent loading and unloading mechanism carries a reagent container to be loaded, an information reader is controlled to read the label of the reagent container to read the reagent information of the reagent container, and the read reagent information is controlled to be written into a memory, and before the reagent container to be loaded is transported to the reagent warehouse by the transport mechanism, the information reader is controlled to write information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable; After controlling the transport mechanism to transport the reagent container to be loaded from the reagent loading and unloading mechanism to the reagent warehouse, at least the reagent quantity in the reagent information corresponding to the reagent container in the memory is updated in real time; when the reagent container needs to be discarded, the transport mechanism is controlled to transport the reagent container to the reagent loading and unloading mechanism for discarding.

8. The sample analysis method according to claim 7, characterized in that: The control information reader / writer writes information to the label of the reagent container so that the reagent information corresponding to the label is set to be unavailable, including: The information reader / writer is controlled to write information to the label of the reagent container so that the reagent information corresponding to the label is zero.

9. The sample analysis method according to claim 7, characterized in that: When the reagent bin carries a reagent container to be unloaded, the transport mechanism is controlled to transport the reagent container from the reagent bin to the reagent loading and unloading mechanism for storage; the latest reagent quantity of the reagent container is obtained from the memory, and the information reader is controlled to write the latest reagent quantity of the reagent container into its label to update the reagent quantity information in its label.

10. The sample analysis method according to any one of claims 7 to 9, characterized in that: The reagent compartment has a working time sequence cycle, each working time sequence cycle of the reagent compartment includes a reagent suction time period, and one or more of the working time sequence cycles of the reagent compartment also includes a reagent loading time period: During the reagent aspiration time period, the reagent compartment is controlled to dispatch the reagent container it carries to the reagent aspiration position for the reagent dispensing component to aspirate; When the reagent loading and unloading mechanism carries a reagent container to be loaded, the conveying mechanism is controlled to convey the reagent container to be loaded from the reagent loading and unloading mechanism to above the preset position of the reagent warehouse, and within the reagent suction time period in the working timing cycle of the reagent warehouse, the conveying mechanism is controlled to place the reagent container to be loaded from above the preset position of the reagent warehouse into the reagent warehouse; or, when the reagent warehouse carries a reagent container to be unloaded or discarded, the conveying mechanism is controlled to take out the reagent container from the reagent warehouse within the reagent suction time period in the working timing cycle of the reagent warehouse, wherein the taken out reagent container will be conveyed to the reagent loading and unloading mechanism by the conveying mechanism.

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