A fully enclosed sodium alginate capsule forming device

Abstract

The application discloses a kind of fully closed sodium alginate capsule forming device, including fixed body, fixed body is connected with positioning body by screwing or welding mode on it, the front end surface of the fixed body is connected with forming cavity by screwing or welding mode, the bottom of the forming cavity is fixedly connected with processing cavity, the forming cavity is communicated with processing cavity, the bottom of the processing cavity is fixedly provided with magnetic stirrer;High-voltage direct-current generator is fixedly provided on the forming cavity, the fixed cavity is connected with the inner wall of the forming cavity by screwing or welding mode, the fixed cavity is provided with communication pipe, and the communication pipe is communicated with the liquid guide device;Flow guide plate is fixedly provided in the processing cavity, the flow guide plate is connected with the inner wall of the processing cavity by sliding mode, and positioning plate is fixedly provided below the two sides of the flow guide plate, hydraulic lifting cylinder is fixedly provided between the positioning plate and the flow guide plate, and flow guide hole is formed in the flow guide plate.

Description

Technical Field

[0001] This invention relates to the field of capsule forming technology, and in particular to a fully enclosed sodium alginate capsule forming device. Background Technology

[0002] Alginate and its derivatives, as one of the main wall materials for microcapsule preparation using the sharp-pore coagulation bath method, can be used to encapsulate hydrophobic active ingredients. Calcium alginate microcapsules, made from these materials, are suitable for applications in biopharmaceuticals, food, health products, and skincare products due to the different active ingredients they encapsulate. Among these, the application in biopharmaceuticals, particularly the encapsulation of bioactive living cells, is the most complex. Microcapsules have recently attracted much attention due to their important role in drug sustained release and implantable therapeutic regimens. Biocapsules are made by encapsulating living cells, enzymes, etc., with biocompatible wall materials. The selective permeability of the microcapsule membrane prevents substances larger than a certain molecular weight from diffusing into the capsule, while nutrients from the biological environment and bioactive substances or small molecule products secreted by cells can freely enter and exit the microcapsule, thereby achieving immune isolation.

[0003] Traditional microcapsule preparation equipment is unsuitable for industrial production of biological and food microcapsules because it often uses a single sharp orifice, has low yield, is not made entirely of stainless steel, and cannot be thoroughly sterilized. Furthermore, the self-assembly equipment is rudimentary and requires multiple liquid changes and cell rinsing, which may lead to contamination. The main problem with existing technology is that there is currently no similar equipment in China, making it impossible to form a polymer microcapsule preparation instrument with controllable particle size and uniform size. Summary of the Invention

[0004] The purpose of this invention is to provide a fully enclosed sodium alginate capsule forming device to solve the problems mentioned in the background art.

[0005] The objective of this invention is achieved through the following technical solution: a fully enclosed sodium alginate capsule forming device, comprising a fixed body, a positioning body connected to the fixed body by screws or welding, a forming cavity connected to the front end face of the fixed body by screws or welding, a processing cavity fixedly connected to the bottom of the forming cavity, the forming cavity communicating with the processing cavity, and a magnetic stirrer fixedly provided at the bottom of the processing cavity;

[0006] A high-voltage DC generator is fixedly installed on the molding cavity. The molding cavity is connected to the fixed cavity near the inner wall by screws or welding. A connecting pipe is provided in the fixed cavity, and the connecting pipe is connected to the liquid guiding device.

[0007] A guide plate is fixedly installed inside the processing chamber. The guide plate is slidably connected to the inner wall of the processing chamber. Positioning plates are fixedly installed on both sides below the guide plate. A hydraulic lifting cylinder is fixedly installed between the positioning plates and the guide plate.

[0008] Furthermore, a guide hole is fixedly opened on the guide plate, and the guide hole is connected to the booster pipe connected to the connecting pipe;

[0009] The booster tube has a hollow tube structure, and the bottom of the booster tube is flat, conical, or wedge-shaped.

[0010] The bottom of the booster tube is connected to the positive terminal of the high-voltage DC generator via a connecting wire;

[0011] The guide plate is connected to the negative terminal of the high-voltage DC generator via a connecting wire.

[0012] Furthermore, a stirring chamber is fixedly provided on the fixed body, and a stirring shaft is provided inside the stirring chamber. The stirring shaft is driven to rotate by an external motor. The stirring chamber is connected to a buffer chamber through a connecting pipe, and the buffer chamber is connected to a pressure pump chamber.

[0013] Furthermore, the liquid guiding device is a booster, and the end of the liquid guiding device is embedded in the positioning hole of the positioning body. The positioning hole is a countersunk hole structure. A hydraulic telescopic cylinder is fixedly provided at the rear end of the positioning body, and the end of the hydraulic telescopic cylinder is in contact with the rear end of the liquid guiding device.

[0014] Furthermore, a drying chamber and a polishing chamber are fixedly provided on the fixed body near the processing chamber;

[0015] The drying chamber is divided into two cavities, an inner and an outer one. A rotary motor is installed at the bottom of the inner cavity, a stirring rod is installed at the bottom of the inner cavity, and a drying lamp tube is fixed on the inner wall of the inner cavity.

[0016] The polishing chamber is divided into inner and outer cavities. The bottom of the inner cavity is equipped with a rotary motor, and the inner cavity rotates 360 degrees around the outer cavity.

[0017] Furthermore, an inlay groove is fixedly formed on the inner wall of the inner sleeve cavity, and the inlay groove is evenly distributed along the inner wall of the inner sleeve cavity;

[0018] A positioning plate is inserted into the inlay groove. Positioning posts are spaced apart on the positioning plate by means of screws or welding. A spiral polishing frame is inserted and sleeved on the positioning post. The spiral spacing of the spiral polishing frame is smaller than the diameter of the formed sodium alginate capsule.

[0019] Furthermore, a light rod is connected to the positioning post by screws and / or welding. The diameter of the light rod is larger than the diameter of the positioning post, and a circular spherical structure is fixed on the circumferential surface of the light rod.

[0020] Furthermore, the liquid guiding device is a tank structure, one end of the liquid guiding device is directly connected to the pressure pump chamber, the other end of the liquid guiding device is connected to the connecting pipe, the connecting pipe is connected to the spray pipe, and a nozzle is fixedly provided at the end of the spray pipe;

[0021] The nozzle has an umbrella-shaped or flat plate-shaped structure design;

[0022] Two injection tubes are provided and arranged symmetrically. The ends of the injection tubes are respectively connected to the positive and negative terminals of a high-voltage DC power supply.

[0023] Furthermore, the guide plate is configured as an arc-shaped plate structure, the arc-shaped position on the guide plate is a solid surface, and the plane where the solid surfaces intersect is the leakage area.

[0024] Furthermore, the outer circumferential wall of the processing cavity is evenly distributed with fixing blocks, and an aluminum foil plate connected to the high voltage DC generator is inserted into the fixing blocks. The aluminum foil plate is hollow cylindrical and can slide up and down along the fixing blocks. The fixing blocks are fixedly opened with positioning holes.

[0025] A guide plate fixing groove is fixedly opened on the inner circumference of the processing cavity. The guide plate is cylindrical and has a leakage hole at the center. A sliding block that cooperates with the guide plate fixing groove is fixed on the circumference of the guide plate. A telescopic rod is provided between the sliding block and the guide plate.

[0026] Compared with the prior art, the beneficial effects of the present invention are as follows: The electrostatic capsule integrated molding equipment of the present invention is controlled by a tunable voltage electrostatic generator. The present invention adopts a fully sealed one-time encapsulation equipment with a booster structure, which avoids the possibility of contamination during liquid change. At the same time, in addition to the booster structure, the present invention is equipped with a drying chamber and a polishing chamber fixed in the processing chamber to dry and polish the processed capsules, achieving integrated molding. The present invention has a stirring chamber fixed on the fixed body, and a stirring shaft is provided inside the stirring chamber. The stirring shaft is driven to rotate by an external motor. The stirring chamber is connected to a buffer chamber through a connecting pipe. The buffer chamber is connected to a pressure pump chamber, and the mixture in the stirring chamber is directly drawn by a pressure pump installed between the stirring chamber and the buffer chamber.

[0027] This invention uses a high-voltage electrostatic encapsulation device (electrostatic spraying method) to prepare a biodegradable sodium alginate microcapsule forming device, and the minimum particle size of the microcapsules produced can be 50 μm.

[0028] The particle size of the formed capsules is determined by adjusting the distance between the positive and negative electrodes of the electrostatic device, the syringe propulsion speed, and the voltage. The microcapsules formed by this invention can be loaded with drugs and cells for clinical and basic experimental research. They are biodegradable and can be absorbed after implantation into the human body. The device of this invention can use sodium alginate, calcium chloride (or barium chloride), and protamine (or chitosan) to form cell-carrying microcapsules. Attached Figure Description

[0029] Figure 1 This is a three-dimensional schematic diagram of the present invention;

[0030] Figure 2 This is a top view of the present invention;

[0031] Figure 3 This is a schematic diagram of the three-dimensional structure of the processing cavity of the present invention;

[0032] Figure 4 This is a top view schematic diagram of the processing cavity of the present invention;

[0033] Figure 5 This is a three-dimensional schematic diagram of the connection between the positioning plate and the positioning post of the present invention;

[0034] Figure 6 This is a schematic diagram of the positioning plate and positioning post of the present invention;

[0035] Figure 7 This is a three-dimensional schematic diagram of the booster tube and guide plate of the present invention;

[0036] Figure 8 This is a three-dimensional schematic diagram of the injection tube of the present invention;

[0037] Figure 9 This is a schematic cross-sectional view of the injection pipe of the present invention;

[0038] Figure 10 This is a schematic diagram of another state of the guide plate of the present invention. Detailed Implementation

[0039] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0040] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0041] In the description of this invention, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0042] like Figure 1-10 As shown, a fully enclosed sodium alginate capsule forming device includes a fixed body 1, a positioning body 2 connected to the fixed body 1 by screws or welding, a forming cavity 8 connected to the front end face of the fixed body 1 by screws or welding, a processing cavity 13 fixedly connected to the bottom of the forming cavity 8, the forming cavity 8 communicating with the processing cavity 13, and a magnetic stirrer 14 fixedly provided at the bottom of the processing cavity 13;

[0043] A high-voltage DC generator 11 is fixedly installed on the molding cavity 8. The molding cavity 8 is connected to the fixed cavity 9 near the inner wall by screws or welding. The fixed cavity 9 is provided with a connecting pipe 10, which is connected to the liquid guiding device 7.

[0044] The fixed cavity 9 is connected to the molding cavity 8 in size or is half the size of the molding cavity 8.

[0045] A guide plate 12 is fixedly installed inside the processing chamber 13. The guide plate 12 is connected to the inner wall of the processing chamber 13 by a sliding manner. Positioning plates are fixedly installed on both sides below the guide plate 12. A hydraulic lifting cylinder is fixedly installed between the positioning plate and the guide plate 12.

[0046] In order to facilitate the formation of an electrostatic field effect by the high-voltage DC generator during use, a further preferred embodiment of the present invention is that the guide plate 12 is fixedly provided with a guide hole, and the guide hole is connected to the booster pipe 23 connected to the connecting pipe 10.

[0047] The booster tube 23 has a hollow tube structure, and the bottom of the booster tube 23 is flat, conical, or wedge-shaped.

[0048] The bottom of the booster tube 23 is connected to the positive terminal of the high-voltage DC generator 11 via a connecting wire;

[0049] The guide plate 12 is connected to the negative terminal of the high voltage DC generator 11 via a connecting wire.

[0050] To facilitate integrated mixing and conveying during use and avoid contamination, a further preferred embodiment of the present invention is that a mixing chamber 6 is fixedly provided on the fixed body 1, a mixing shaft is provided inside the mixing chamber 6, the mixing shaft is driven to rotate by an external motor, the mixing chamber 6 is connected to a buffer chamber 5 through a connecting pipe, and the buffer chamber 5 is connected to a pressure pump chamber 3.

[0051] To avoid the possibility of contamination during fluid changes during use, a further preferred embodiment of the present invention is that the fluid guiding device 7 is a booster, the end of the fluid guiding device 7 is embedded in the positioning hole of the positioning body 2, the positioning hole is a countersunk hole structure, and a hydraulic telescopic cylinder 4 is fixedly provided at the rear end of the positioning body 2, the end of the hydraulic telescopic cylinder 4 is in contact with the rear end of the fluid guiding device 7.

[0052] The booster is fixed by the positioning body 2, and the inner tube of the booster is moved by the extension and retraction of the hydraulic telescopic cylinder 4 at the rear end, so as to promote the material in the booster to enter the booster tube 23.

[0053] In order to facilitate the integrated processing of the molded capsules during use, a further preferred embodiment of the present invention is that a drying chamber 15 and a polishing chamber 16 are fixedly provided on the fixing body 1 near the processing chamber 13;

[0054] The drying chamber 15 is divided into two cavities, an inner and an outer one. The bottom of the inner cavity is equipped with a rotary motor and a stirring rod. A drying lamp tube is fixed on the inner wall of the inner cavity.

[0055] The polishing chamber 16 is divided into inner and outer cavities. The bottom of the inner cavity is equipped with a rotary motor, and the inner cavity rotates 360 degrees around the outer cavity.

[0056] The drying chamber 15 is configured to perform surface drying treatment on the formed sodium alginate, and at the same time, to perform surface polishing treatment on the sodium alginate.

[0057] To facilitate polishing of the molded capsule during use, a further preferred embodiment of the present invention is that an inlay groove 18 is fixedly opened on the inner wall of the inner sleeve cavity, and the inlay groove 18 is evenly distributed along the inner wall of the inner sleeve cavity.

[0058] The positioning plate 19 is inserted into the inlay groove 18. Positioning posts 20 are provided on the positioning plate 19 at intervals by means of screws or welding. A spiral polishing frame 21 is inserted and sleeved on the positioning post 20. The spiral spacing of the spiral polishing frame 21 is smaller than the diameter of the formed sodium alginate capsule.

[0059] To facilitate better polishing of the formed capsule inside the cavity during use, a further preferred embodiment of the present invention is that the positioning post 20 is connected to the light rod 22 by screws and / or welding, the diameter of the light rod 22 is larger than the diameter of the positioning post 20, and a circular spherical structure is fixed on the circumferential surface of the light rod 22.

[0060] To facilitate integration during use, a further preferred embodiment of the present invention is that the liquid guiding device 7 is a tank structure, one end of the liquid guiding device 7 is directly connected to the pressure pump chamber 3, the other end of the liquid guiding device 7 is connected to the connecting pipe 10, the connecting pipe 10 is connected to the spray pipe 24, and a nozzle 25 is fixedly provided at the end of the spray pipe 24.

[0061] In order to control the forming capsule in use, a further preferred embodiment of the present invention is that the nozzle 25 is designed with an umbrella-shaped or flat plate-shaped structure.

[0062] In order to facilitate the formation of a capsule by cooperating with the guide plate through the injection pipe 24 during use, a further preferred embodiment of the present invention is that two injection pipes 24 are provided and arranged symmetrically, and the ends of the injection pipes 24 are respectively connected to the positive and negative terminals of a high-voltage DC power supply.

[0063] In order to facilitate a better forming effect through the cooperation of the corresponding guide plate 12 and the inclined spray pipe 24 in the use state, a further preferred embodiment of the present invention is that the guide plate 12 is set as an arc-shaped plate structure, the arc-shaped position on the guide plate 12 is a solid surface 24, and the plane intersecting the solid surface 24 is a leakage hole area 26.

[0064] The inclination angle of the spray pipe 24 is set along the direction of the solid surface 24, and the spray pipe 24 is either parallel to the solid surface 24 or at an angle to the solid surface 24.

[0065] Due to the different structural forms adopted by the jet pipe, a conical inlet is set at the inlet end, so that after pressurization, it reaches the nozzle position 25 through the straight pipe end.

[0066] To facilitate the formation of capsules using different field-effect modes during use, a further preferred embodiment of the present invention is that the outer circumferential wall of the processing cavity 13 is evenly distributed with fixing blocks, and an aluminum foil plate 17 connected to the high voltage DC generator 11 is inserted and fitted onto the fixing blocks. The aluminum foil plate 17 is a hollow cylinder and can slide up and down along the fixing blocks. The fixing blocks are fixedly provided with positioning holes.

[0067] A guide plate fixing groove is fixedly opened on the inner circumference of the processing cavity 13. The guide plate 12 is cylindrical and has a leakage hole at the center. A sliding block that cooperates with the guide plate fixing groove is fixedly provided on the circumference of the guide plate 12. A telescopic rod is provided between the sliding block and the guide plate 12.

[0068] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0069] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A fully enclosed sodium alginate capsule forming device, characterized in that: The system includes a fixed body (1), on which a positioning body (2) is connected by screws or welding. A forming cavity (8) is connected to the front end face of the fixed body (1) by screws or welding. A processing cavity (13) is fixedly connected to the bottom of the forming cavity (8). The forming cavity (8) and the processing cavity (13) are in communication. A magnetic stirrer (14) is fixedly provided at the bottom of the processing cavity (13). A high-voltage DC generator (11) is fixedly installed on the molding cavity (8). The molding cavity (8) is connected to the fixed cavity (9) near the inner wall by screws or welding. The fixed cavity (9) is provided with a connecting pipe (10), which is connected to the liquid guiding device (7). A guide plate (12) is fixedly provided inside the processing chamber (13). The guide plate (12) is connected to the inner wall of the processing chamber (13) by sliding. Positioning plates are fixedly provided on both sides below the guide plate (12). A hydraulic lifting cylinder is fixedly provided between the positioning plate and the guide plate (12). The guide plate (12) has a guide hole fixedly opened on it, and the guide hole is connected to the booster pipe (23) connected to the connecting pipe (10); The booster tube (23) has a hollow tube structure, and the bottom of the booster tube (23) is flat, conical, or wedge-shaped. The bottom of the booster tube (23) is connected to the positive terminal of the high voltage DC generator (11) via a connecting wire; The guide plate (12) is connected to the negative terminal of the high voltage DC generator (11) via a connecting line.

2. The fully enclosed sodium alginate capsule forming device according to claim 1, characterized in that: The fixed body (1) is provided with a stirring chamber (6), and the stirring chamber (6) is provided with a stirring shaft inside. The stirring shaft is driven to rotate by an external motor. The stirring chamber (6) is connected to the buffer chamber (5) through a connecting pipe. The buffer chamber (5) is connected to the pressure pump chamber (3).

3. The fully enclosed sodium alginate capsule forming device according to claim 2, characterized in that: The liquid guiding device (7) is a booster. The end of the liquid guiding device (7) is embedded in the positioning hole of the positioning body (2). The positioning hole is a countersunk hole structure. The rear end of the positioning body (2) is fixedly provided with a hydraulic telescopic cylinder (4). The end of the hydraulic telescopic cylinder (4) is in contact with the rear end of the liquid guiding device (7).

4. The fully enclosed sodium alginate capsule forming device according to claim 3, characterized in that: A drying chamber (15) and a polishing chamber (16) are fixedly provided on the fixed body (1) near the processing chamber (13). The drying chamber (15) is divided into two cavities, an inner and an outer one. The bottom of the inner cavity is equipped with a rotary motor and a stirring rod. A drying lamp tube is fixed on the inner wall of the inner cavity. The polishing chamber (16) is divided into two cavities, an inner and an outer. The bottom of the inner cavity is equipped with a rotary motor, and the inner cavity rotates 360 degrees around the outer cavity.

5. The fully enclosed sodium alginate capsule forming device according to claim 4, characterized in that: An inlay groove (18) is fixedly opened on the inner wall of the inner sleeve cavity, and the inlay groove (18) is evenly distributed along the inner wall of the inner sleeve cavity. The positioning plate (19) is inserted into the inlay groove (18). Positioning posts (20) are provided on the positioning plate (19) at intervals by screwing or welding. A spiral polishing frame (21) is inserted into the positioning post (20). The spiral spacing of the spiral polishing frame (21) is smaller than the diameter of the formed sodium alginate capsule.

6. The fully enclosed sodium alginate capsule forming device according to claim 5, characterized in that: The positioning post (20) is connected to the light rod (22) by screws and / or welding. The diameter of the light rod (22) is larger than the diameter of the positioning post (20). A circular spherical structure is fixed on the circumferential surface of the light rod (22).

7. The fully enclosed sodium alginate capsule forming device according to claim 6, characterized in that: The liquid guiding device (7) is a tank structure. One end of the liquid guiding device (7) is directly connected to the pressure pump chamber (3), and the other end of the liquid guiding device (7) is connected to the connecting pipe (10). The connecting pipe (10) is connected to the spray pipe (24), and the spray pipe (24) is fixedly provided with a nozzle (25). The nozzle (25) is designed with an umbrella-shaped or flat plate structure; Two injection pipes (24) are provided and arranged symmetrically. The ends of the injection pipes (24) are respectively connected to the positive and negative terminals of the high voltage DC power supply.

8. The fully enclosed sodium alginate capsule forming device according to claim 7, characterized in that: The outer circumferential wall of the processing cavity (13) is evenly distributed with fixed blocks. An aluminum foil plate (17) connected to the high voltage DC generator (11) is inserted into the fixed block. The aluminum foil plate (17) is a hollow cylinder and can slide up and down along the fixed block. A positioning hole is fixedly opened on the fixed block. The processing chamber (13) has a guide plate fixing groove fixedly opened on its inner circumference. The guide plate (12) is cylindrical and has a leakage hole at the center. A sliding block that cooperates with the guide plate fixing groove is fixedly provided on the circumference of the guide plate (12). A telescopic rod is provided between the sliding block and the guide plate (12).

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