A production line of microfluidic chips

Abstract

The application discloses a production line of micro-fluidic chips, which comprises a forming die and an injection molding equipment used for injection molding of the forming die, and a material taking device used for clamping the injection molding piece is arranged on the injection molding equipment; further comprising a detection device and a storage device, a first conveying belt is arranged between the detection device and the injection molding equipment, and a second conveying belt is arranged between the detection device and the storage device; further comprising a carrying device used for carrying the injection molding piece between the first conveying belt and the second conveying belt; the production line of the micro-fluidic chips is high in production efficiency and good in product quality, the micro-fluidic chips are injection molded through the injection molding equipment and the forming die, and the molded micro-fluidic chips are detected through the detection device, so that the micro-fluidic chips entering the storage device are all qualified products, and the production of the micro-fluidic chips with high efficiency and high quality is realized.

Description

TECHNICAL FIELD

[0001] The present application relates to the microfluidic chip production technical field, and in particular to a microfluidic chip production line. BACKGROUND

[0002] Microfluidic chip technology is to integrate the sample preparation, reaction, separation, detection and other basic operation units of biological, chemical and medical analysis process on a micron chip to automatically complete the whole analysis process. Due to its great potential in the fields of biology, chemistry, medicine and other fields, it has developed into a new research field of biology, chemistry, medicine, fluid, electronics, materials and mechanics.

[0003] Polymer (PDMS) is a model glue for making microfluidic chips, which is convenient to process and shape, and the raw material cost is low, and is suitable for mass production. By pouring liquid polymer on the microfluidic chip replication mold, the pattern consistent with the mold can be formed on the surface of the polymer after the polymer is solidified and separated from the mold.

[0004] The commonly used molding method is to inject PDMS into the mold, to mold the semi-finished product, and then to perform photoetching on the finished product; or to directly pour PDMS into the mold with a template, to wait for cooling and solidification, and then to cut the chip with a knife.

[0005] The mold formed by the above method must be placed on a completely horizontal operation table, otherwise the surface of the chip is uneven, and in the process of molding, the surface tension of the injection liquid will cause the upper surface of the injection liquid to be curved after solidification, and batch production cannot be performed.

[0006] Since the flow channel of the microfluidic chip is relatively narrow, the surface tension of the injection liquid will cause the injection liquid to not well adhere to the surface of the mold during the injection molding process, resulting in uneven surface of the flow channel of the microfluidic chip, unqualified product quality, and greatly affected use effect; but since the flow channel is relatively small and the microfluidic chip is transparent as a whole, the defects cannot be well observed by the human eye, which not only affects the production efficiency, but also greatly affects the qualified rate of product shipment.

[0007] Based on the above situation, the present application provides a microfluidic chip production line, which can effectively solve one or more of the above problems. SUMMARY

[0008] The purpose of the present application is to provide a microfluidic chip production line.

[0009] The present application is realized by the following technical scheme:

[0010] The production line of the micro-fluidic chip comprises a forming die and an injection molding device for injection molding of the forming die, the injection molding device is provided with a material taking device for clamping the injection molded part; further comprising a detection device and a storage device, the detection device is provided with a first conveying belt between the injection molding device, the detection device and the storage device are provided with a second conveying belt; the first conveying belt and the second conveying belt are further provided with a carrying device for carrying the injection molded part.

[0011] Preferably, the forming die comprises an upper die structure and a lower die structure; the upper die structure comprises an upper die and an upper die fixing plate for fixing the upper die; the upper die is further provided with a liquid injection assembly above; the lower die structure comprises a lower die and a lower die fixing plate for mounting the lower die; the lower die fixing plate is provided with a lower die base plate below; the lower die base plate and the lower die are provided with a jacking assembly therebetween; the jacking assembly is further provided with a lower die vertical plate connected between the lower die fixing plate and the lower die base plate.

[0012] Preferably, the bottom surface of the upper die is provided with a male die; the upper die is provided with a plurality of flow channels;

[0013] The male die is provided with a plurality of air holes;

[0014] The liquid injection assembly comprises a liquid injection plate and a liquid distribution plate, the liquid injection plate is connected with a liquid injection interface, and a funnel-shaped liquid injection port is formed in the liquid injection interface;

[0015] The bottom of the liquid distribution plate is embedded in the upper die fixing plate; the top of the liquid distribution plate is provided with a liquid inlet corresponding to the liquid injection port, and the bottom of the liquid distribution plate is provided with a liquid outlet corresponding to each flow channel, and each liquid outlet is communicated to the liquid inlet.

[0016] Preferably, the lower die is slidingly embedded in the lower die fixing plate, and a plurality of first through holes are formed in the lower die;

[0017] The jacking assembly comprises a jacking top plate and a jacking bottom plate, and a plurality of guide columns are arranged between the jacking top plate and the jacking bottom plate; the jacking top plate is further provided with a second through hole corresponding to each first through hole;

[0018] The jacking top plate and the jacking bottom plate are further provided with a lifting plate, and the lifting plate is slidingly connected to the guide columns; the top surface of the lifting plate is provided with a jack corresponding to each second through hole, and a lifting assembly is arranged below the lifting plate;

[0019] The lifting assembly comprises a first transmission block fixed to the lifting plate and a lifting driving member fixed to the jacking bottom plate, and a second transmission block is connected to the lifting driving member for driving the first transmission block to lift; the first transmission block and the second transmission block are driven through the inclined surface.

[0020] The upper portion of the lifting plate is further provided with a spring sleeved on the top rod.

[0021] Preferably, the detection device comprises a clamping structure and a detection structure; the clamping structure comprises a clamping mounting frame and a clamping assembly arranged on the clamping mounting frame; the detection structure comprises a detection mounting frame and a detection assembly mounted on the detection mounting frame, and the detection mounting frame is slidingly connected to the clamping mounting frame through a displacement assembly; the detection assembly comprises a plurality of groups of laser emitters arranged above the clamping assembly, each group of laser emitters comprising a plurality of laser emitters; the detection assembly further comprises a signal receiving plate arranged below the clamping assembly, and the signal receiving plate is provided with a plurality of photosensitive elements.

[0022] Preferably, the detection assembly and the detection mounting frame are connected through a rotating seat and a rotating mounting strip, the bottom surface of the rotating mounting strip is a plane, and a plurality of rows of the groups of laser emitters are mounted on the bottom surface of the rotating mounting strip.

[0023] One end of the rotating mounting strip is provided with a knob.

[0024] Both ends of the bottom surface of the signal receiving plate are connected to the detection mounting frame through a lifting structure.

[0025] The lifting structure comprises a first rotating seat arranged on the detection mounting frame and a plurality of second rotating seats arranged on the bottom surface of the signal receiving plate; the first rotating seat is provided with a rotating block, the rotating block is connected with an adjusting rod, the adjusting rod is sleeved with a stop block, the adjusting rod and the stop block are connected through threads, and the stop block is clamped in the rotating block; the top end of the adjusting rod is connected with a lifting connecting piece, and the lifting connecting piece is rotatably connected to the second rotating seat; the bottom end of the adjusting rod is connected with a rotating disc.

[0026] The displacement assembly comprises a plurality of second guide rails parallel to each other, and the second guide rails are provided with second sliding blocks connected with the detection mounting frame; the displacement assembly further comprises a displacement driving element arranged between the detection mounting frame and the clamping mounting frame.

[0027] The displacement driving element is a linear motor.

[0028] Preferably, the clamping assembly comprises a clamping disc and two mutually parallel clamping strips, and a convex strip for lifting the micro-fluidic chip is arranged on the inner side of the two clamping strips; the bottom of the clamping disc is provided with a rectangular light transmission window; the clamping assembly further comprises two mutually parallel first guide rails, and the two first guide rails are both perpendicular to the clamping strips; the two first guide rails are respectively arranged at the two ends of the light transmission window, and each clamping strip is connected to the two first guide rails through a first sliding block.

[0029] Both ends of the clamping disc are also provided with clamping driving members, and a driving sliding block is arranged on the clamping driving member corresponding to each clamping strip, and the driving sliding block and the clamping strip are connected through a driving connecting member.

[0030] Preferably, the conveying device comprises a conveying rail arranged above the detection device, the first conveying belt and the second conveying belt, and two conveying manipulators are arranged on the conveying rail.

[0031] Preferably, the injection molding equipment is a horizontal injection molding machine or a vertical injection molding machine.

[0032] Preferably, the material taking device is a three-axis manipulator.

[0033] Compared with the prior art, the micro-fluidic chip production line has the following advantages and beneficial effects:

[0034] The micro-fluidic chip production line is efficient and has good product quality, the micro-fluidic chip is injection molded through the injection molding equipment and the molding mold, and the molded micro-fluidic chip is detected by the detection device, so that the micro-fluidic chips entering the storage device are all qualified products, and efficient and high-quality micro-fluidic chip production is realized. BRIEF DESCRIPTION OF DRAWINGS

[0035] Figure 1 It is a structural schematic view of the present application.

[0036] Figure 2 It is a structural schematic view of the molding mold.

[0037] Figure 3 It is a sectional structural schematic view of the molding mold.

[0038] Figure 4 It is a structural schematic view of the liquid distribution plate.

[0039] Figure 5 It is a structural schematic view of the liquid distribution plate from another angle.

[0040] Figure 6 It is a structural schematic view of the upper mold and the upper mold fixing plate.

[0041] Figure 7 Another angle structural schematic view of the upper die and the upper die fixing plate of the present application.

[0042] Figure 8 For Figure 7 Partial structural schematic view at A in the middle.

[0043] Figure 9 Structural schematic view of the lower die and the lower die fixing plate of the present application.

[0044] Figure 10 Structural schematic view of the jacking top plate of the present application.

[0045] Figure 11 Structural schematic view of the lower die structure of the present application.

[0046] Figure 12 Structural schematic view of the lifting plate and the lifting assembly of the present application.

[0047] Figure 13 Structural schematic view of the detection device of the present application.

[0048] Figure 14 Structural schematic view of the detection device of the present application.

[0049] Figure 15 For Figure 14 Partial enlarged schematic view at B.

[0050] Figure 16 Structural schematic view of the clamping assembly of the present application. DETAILED DESCRIPTION

[0051] In order for those skilled in the art to better understand the technical solutions of the present application, the preferred embodiments of the present application are described below in combination with specific examples, but it should be understood that the drawings are only used for illustrative description and cannot be understood as a limitation of the present patent; in order to better illustrate the present embodiment, some components in the drawings may be omitted, enlarged or reduced, and do not represent the actual product size; for those skilled in the art, it is understandable that some well-known structures and their descriptions in the drawings may be omitted. The positional relationship described in the drawings is only used for illustrative description and cannot be understood as a limitation of the present patent. Example 1:

[0052] As Figures 1 to 16As shown, the present application provides a production line of microfluidic chip, comprising a forming die 1 and an injection molding equipment 2 for injection molding of the forming die 1, the injection molding equipment 2 is provided with a material taking device 3 for clamping the injection molding part; further comprising a detection device 4 and a storage device 5, the detection device 4 and the injection molding equipment 2 are provided with a first conveying belt 6, the detection device 4 and the storage device 5 are provided with a second conveying belt 7; the first conveying belt 6 and the second conveying belt 7 are further provided with a carrying device 8 for carrying the injection molding part.

[0053] The present application comprises injection molding of microfluidic chip by the injection molding equipment 2 and the forming die 1, and detection of the formed microfluidic chip by the detection device 4, ensuring that the microfluidic chip entering the storage device 5 is all qualified products, realizing efficient and high-quality production of microfluidic chip.

[0054] Manual visual inspection can be arranged at the first conveying belt 6, and if there are obvious defects, they can be directly taken out and sent to the waste product place.

[0055] The detection device 4 and the second conveying belt 7 are further provided with a waste box 9, and the unqualified microfluidic chip in the detection device 4 is directly sent into the waste box by the carrying device 8.

[0056] Further, in another embodiment, the forming die 1 comprises an upper die structure and a lower die structure; the upper die structure comprises an upper die 11 and an upper die fixing plate 12 for fixing the upper die 11; the upper die 11 is further provided with a liquid injection assembly 13 above; the lower die structure comprises a lower die 14 and a lower die fixing plate 15 for mounting the lower die 14; the lower die fixing plate 15 is provided with a lower die bottom plate 16 below; the lower die bottom plate 16 and the lower die 14 are provided with a jacking assembly 17; the jacking assembly 17 is further provided with a lower die vertical plate 161 connected between the lower die fixing plate 15 and the lower die bottom plate 16.

[0057] Through the upper die 11 and the lower die 14, a mold cavity for injection molding is formed, and the injection liquid flows into the mold cavity to realize injection molding of the microfluidic chip, and the jacking assembly 17 lifts the lower die 14 during the injection molding process to extrude the mold cavity space and ensure that the injection liquid can fill the mold cavity, ensuring precise injection molding and good injection effect.

[0058] The lower die vertical plate 161 is provided with a protruding block inward at both ends, which can limit the jacking assembly 17.

[0059] Further, in another embodiment, the bottom surface of the upper die 11 is provided with a convex die 111; the upper die 11 is provided with a plurality of flow channels 112.

[0060] The convex die 111 is provided with a plurality of air holes 1111.

[0061] Since several independent internal spaces are formed in the punch 111, after the injection liquid seals the openings of the internal spaces, the internal air cannot be discharged, which causes the injection to fail to fill the mold cavity and the workpiece to fail to be formed; and through the air hole, the air in the internal space can be discharged in time, ensuring better injection effect.

[0062] The liquid injection assembly 13 comprises a liquid injection plate 131 and a liquid distribution plate 132, the liquid injection plate 131 is connected with a liquid injection port 1311, and a funnel-shaped liquid injection port 13111 is arranged in the liquid injection port 1311.

[0063] The funnel-shaped liquid injection port 13111 can better guide the injection liquid into the mold; and the liquid injection port 1311 can be replaced, avoiding the overall replacement of the mold due to the damage of the liquid injection port 1311 after being used for too many times.

[0064] The liquid injection port 1311 can also be replaced to meet different needs of injection molding.

[0065] The bottom of the liquid distribution plate 132 is embedded in the upper mold fixed plate 12; the top of the liquid distribution plate 132 is provided with a liquid inlet 1321 corresponding to the liquid injection port 13111, and the bottom of the liquid distribution plate 132 is respectively provided with a liquid outlet 1322 corresponding to each flow channel 112, and each liquid outlet 1322 is communicated to the liquid inlet 1321.

[0066] Through the liquid distribution plate 132, the injection liquid is better distributed, ensuring that the injection liquid can quickly fill the mold cavity, ensuring that the injection workpiece is more uniform, and ensuring better injection effect.

[0067] Further, in another embodiment, the lower mold 14 is slidingly embedded in the lower mold fixed plate 15, and a plurality of first through holes 141 are arranged in the lower mold 14.

[0068] The lower mold 14 is slidingly connected to the lower mold fixed plate 15, ensuring that the lower mold 14 can adjust the mold cavity space by sliding; during the injection process, the injection liquid is pressurized by reducing the mold cavity space, ensuring that the injection liquid can fill the mold cavity, and ensuring better injection effect.

[0069] The jacking assembly 17 comprises a jacking top plate 171 and a jacking bottom plate 172, and a plurality of guide columns 173 are arranged between the jacking top plate 171 and the jacking bottom plate 172; the jacking top plate 171 is further provided with a second through hole 1711 corresponding to each first through hole 141.

[0070] The middle part of the lower mold base plate 16 is provided with a jacking hole, and when the mold is installed on the injection molding equipment, the driving rod of the cylinder or the hydraulic cylinder on the injection molding equipment will pass through the jacking hole to drive the jacking assembly 17 to rise and fall, thereby driving the lower mold 14 to move.

[0071] The jacking top plate 171 and the jacking bottom plate 172 are also provided with a lifting plate 174, and the lifting plate 174 is slidingly connected to the guide column 173; the top surface of the lifting plate 174 is provided with a top rod 1741 corresponding to each second through hole 1711, and a lifting assembly 175 is arranged below the lifting plate 174.

[0072] The lifting plate 174 is driven to move by the lifting assembly 175, and the top rod 1741 is arranged on the lifting plate 174, and in the moving process, the top rod 1741 is lifted through the second through hole 1711 and the first through hole 141, thereby achieving a better demolding effect.

[0073] The lifting assembly 175 includes a first transmission block 1751 fixed to the lifting plate 174 and a lifting driving member 1752 fixed to the jacking bottom plate 172, and a second transmission block 1753 for driving the first transmission block 1751 to rise and fall is connected to the lifting driving member 1752; the first transmission block 1751 and the second transmission block 1753 are connected through an inclined surface.

[0074] The first transmission block 1751 is a four-prism with a straight-angled trapezoidal cross section, and the upper base of the trapezoid is larger than the lower base; when the lifting plate 174 is lowered to the lowest position, the first transmission block 1751 can play a better supporting role, ensuring that the top rod 1741 will not shake and affect the injection quality; the first transmission block 1751 can also play a positioning role, and when the lifting plate 174 is lowered to the lowest position, the top end of the top rod 1741 is flush with the bottom surface of the inner cavity of the lower mold 14, thereby ensuring a better injection effect; the second transmission block 1753 and the first transmission block 1751 are connected through an inclined surface, and the movement of the second transmission block 1753 in the horizontal direction is converted into the lifting movement of the first transmission block 1751, and the driving process is stable.

[0075] The lifting driving member 1752 can be one of a cylinder, a hydraulic cylinder, a ball screw, a gear and rack assembly, etc.

[0076] The upper part of the lifting plate 174 is also provided with a spring 1754 sleeved on the top rod 1741.

[0077] Through the spring 1754, it is ensured that the lifting plate 174 can normally fall back, thereby ensuring that the next injection effect will not be affected.

[0078] Further, in another embodiment, the detection device 4 comprises a clamping structure 41 and a detection structure 42; the clamping structure 41 comprises a clamping mounting frame 411 and a clamping assembly 412 arranged on the clamping mounting frame 411; the detection structure 42 comprises a detection mounting frame 421 and a detection assembly 422 mounted on the detection mounting frame 421, the detection mounting frame 421 is slidingly connected to the clamping mounting frame 411 through a displacement assembly 423; the detection assembly 422 comprises a plurality of laser emitter groups arranged above the clamping assembly 412, each of the laser emitter groups comprises a plurality of laser emitters 4221; the detection assembly 422 further comprises a signal receiving plate 4222 arranged below the clamping assembly 412, the signal receiving plate 4222 is provided with a plurality of photosensitive elements.

[0079] The microfluidic chip to be detected is fixed by the clamping structure 41, ensuring that there is no deviation during the detection process, and ensuring the accuracy of the test results; through the cooperation of the plurality of laser emitter groups in the detection structure 42 and the signal receiving plate 4222, the microfluidic chip is detected, some defects that cannot be seen by the human eye can be accurately detected, and better detection effect is ensured.

[0080] The laser emitters 4221 emit laser, the laser passes through the microfluidic chip and is incident on the signal receiving plate 4222, and the position of the laser incident on the signal receiving plate 4222 is collected by the photosensitive element, the thickness change on the microfluidic chip is obtained through the deviation of the incident position, and the detection function of the microfluidic chip is realized by comparing the terminal device with the preset data.

[0081] Further, in another embodiment, the detection assembly 422 and the detection mounting frame 421 are connected through a rotating seat 4251 and a rotating mounting strip 4252, the bottom surface of the rotating mounting strip 4252 is a plane, and a plurality of rows of laser emitter groups are mounted on the bottom surface of the rotating mounting strip 4252.

[0082] One end of the rotating mounting strip 4252 is provided with a knob 4253.

[0083] The detection assembly 422 realizes the angle adjustment function of the laser emitter group; the rotating mounting strip 4252 is driven to rotate by the knob 4253, realizing the adjustable laser emission angle; the knob 4253 is arranged, and the rotating angle scale is arranged on the knob 4253, so that the rotating angle can be controlled simply and intuitively.

[0084] By rotating the rotating mounting strip 4252, the light emitting angle of the laser emitter 4221 is adjusted to avoid the laser being vertically incident on the microfluidic chip to cause the refractive direction of the laser to be uncertain, thereby ensuring that the test result is not affected.

[0085] In order to reduce the occupied space of the detection device, the incident angle of the laser is controlled to be between 5 and 30 degrees during the test, and therefore the rotation angle of the rotating mounting strip 4252 is limited to be between 30 degrees in two directions.

[0086] When the laser is vertically incident on the microfluidic chip, the refracted laser and the incident laser are still on the same straight line, so that the receiving point collected by the signal receiving plate 4222 does not change, and therefore the detection cannot be performed.

[0087] When the laser is obliquely incident on the microfluidic chip, the refracted laser and the incident laser are not on the same straight line, and the laser is refracted when being incident on and emitted from the microfluidic chip, so that the receiving point collected by the signal receiving plate 4222 changes. Then, the terminal device analyzes the thickness of the microfluidic chip at the laser refracting position by the distance between the laser emitter 4221 and the microfluidic chip, the distance between the microfluidic chip and the signal receiving plate 4222, and the emitting angle of the laser reflector 4221, and establishes a data group. By comparing the content in the data group with preset data, whether the flow channel of the microfluidic chip meets the requirements can be determined, and the detection purpose is achieved.

[0088] The bottom surface of the signal receiving plate 4222 is connected to the detection mounting frame 421 through the lifting structure 424 at both ends.

[0089] The lifting structure 424 arranged on both sides of the signal receiving plate 4222 can adjust the included angle between the signal receiving plate 4222 and the horizontal plane.

[0090] Since the microfluidic chip is directly exposed to the air during the detection process, and the thickness of the microfluidic chip is small, the air density on the upper and lower sides of the microfluidic chip is almost the same, and the laser is refracted when being incident on and emitted from the microfluidic chip, which causes the laser emitted from the microfluidic chip to be parallel to the laser incident on the microfluidic chip. During the process of receiving the laser signal by the signal receiving plate 4222, the detection result is most accurate when the laser is vertically incident on the laser receiving plate 4222, and therefore the lifting structure 424 needs to be adjusted to be perpendicular to the laser before detection to ensure better detection effect.

[0091] The lifting structure 424 comprises a first rotating seat 4241 arranged on the detection mounting frame 421 and a plurality of second rotating seats 4242 arranged on the bottom surface of the signal receiving plate 4222; the first rotating seat 4241 is provided with a rotating block 4243, the rotating block 4243 is connected with an adjusting rod 4244, the adjusting rod 4244 is sleeved with a retreat-stop block 4245, the adjusting rod 4244 and the retreat-stop block 4245 are connected through threads, and the retreat-stop block 4245 is clamped in the rotating block 4243; the top end of the adjusting rod 4244 is connected with a lifting connecting piece 4246, and the lifting connecting piece 4246 is rotationally connected to the second rotating seat 4242; the bottom end of the adjusting rod 4244 is connected with a rotating disc 4247.

[0092] The adjusting rod 4244 is a screw rod, and is connected with the retreat-stop block 4245 through threads, so that the retreat-stop block 4245 cannot move, and the rotating disc 4247 is rotated to drive the adjusting rod 4244 to rotate, the adjusting rod 4244 is lifted upward, and one side of the signal receiving plate 4222 is pushed upward through the lifting connecting piece 4246 to realize the angle-adjustable function of the signal receiving plate 4222.

[0093] The displacement assembly 423 comprises a plurality of second guide rails 4231 parallel to each other, and the second guide rails 4231 are provided with second sliding blocks 4232 connected with the detection mounting frame 421; the displacement assembly 423 further comprises a displacement driving piece 4233 arranged between the detection mounting frame 421 and the clamping mounting frame 411.

[0094] The displacement driving piece 4233 is a linear motor.

[0095] The linear motor can uniformly and stably drive the detection structure 42 to move, so that the detection structure 42 has better stability during scanning and detection of the microfluidic chip, better detection effect is ensured, and the detection result is accurate.

[0096] Further, in another embodiment, the clamping assembly 412 comprises a clamping disc 4129 and two clamping strips 4121 parallel to each other, and convex strips 4122 for supporting the microfluidic chip are arranged on the inner sides of the two clamping strips 4121; the bottom of the clamping disc 4129 is provided with a rectangular light transmission window 4128; the clamping assembly 412 further comprises two first guide rails 4123 parallel to each other, and the two first guide rails 4123 are perpendicular to the clamping strips 4121; the two first guide rails 4123 are arranged at two ends of the light transmission window 4128 respectively, and each clamping strip 4121 is connected to the two first guide rails 4123 through a first sliding block 4124 respectively.

[0097] The clamping strips 4121 can apply pressure to two opposite sides of the micro-fluidic chip, thereby achieving the fixing effect; in order to ensure better fixing effect, the protrusions 4122 are additionally arranged below the clamping strips 4121, thereby providing an upward lifting force for the micro-fluidic chip during the fixing process of the micro-fluidic chip, simplifying the fixing process and improving the fixing effect; and due to the protrusions 4122, the bottom surface of each micro-fluidic chip is attached to the top surface of the protrusions 4122, so that the incidence angle of the laser on each micro-fluidic chip is the same, the detection error is reduced, the better test effect is ensured, and the reliability of the test result is improved.

[0098] The clamping disc 4129 is further provided with a clamping driving element 4125 at both ends, and the clamping driving element 4125 is provided with a driving sliding block 4126 corresponding to each clamping strip 4121, and the driving sliding block 4126 and the clamping strip 4121 are connected through a driving connecting element 4127.

[0099] The clamping driving element 4125 can adopt a linear driving structure such as a ball screw and a linear motor, and in the embodiment, a ball screw is adopted, and the motor driving the screw is connected with the terminal device, which stops the rotation of the motor as soon as the terminal device detects that the motor is overloaded, and calculates the width of the micro-fluidic chip through the rotation speed and rotation time of the motor; the ball screw can finely adjust the position of the clamping strip and ensure better fixing effect; the two driving sliding blocks 4126 corresponding to the two clamping strips 4121 are opposite to the direction of the screw, so that the screw can drive the two driving sliding blocks 4126 to move inward or outward at the same time when the screw rotates.

[0100] Further, in another embodiment, the conveying device 8 comprises a conveying track 81 arranged above the detection device 4, the first conveying belt 6 and the second conveying belt 7, and two conveying mechanical arms 82 are arranged on the conveying track 81.

[0101] Further, in another embodiment, the injection molding equipment 2 is a horizontal injection molding machine or a vertical injection molding machine.

[0102] Further, in another embodiment, the material taking device 3 is a three-axis mechanical arm.

[0103] According to the description and drawings of the present application, those skilled in the art can easily manufacture or use the micro-fluidic chip production line of the present application, and can produce the positive effects described in the present application.

[0104] Unless otherwise defined, all terms used in disclosing aspects of the application, such as professional terms and technical terms, have the meanings as commonly understood by one of ordinary skill in the art to which this application belongs. By way of non-limiting example, the following definitions are provided.

[0105] Unless otherwise defined, all terms used in disclosing aspects of the application, such as professional terms and technical terms, have the meanings as commonly understood by one of ordinary skill in the art to which this application belongs. By way of non-limiting example, the following definitions are provided.

[0106] The above description is only the preferred embodiment of the application, not any form of limitation on the application, any simple modification and equivalent change of the above embodiment according to the technical essence of the application shall fall within the protection scope of the application.

Claims

1. A production line of microfluidic chips, characterized in that: The utility model provides a kind of injection molding equipment, including forming mould (1) and for the injection molding of forming mould (1), the injection molding equipment (2) is equipped with for the material taking device (3) of clamping injection molding piece;It further includes detection device (4) and storage device (5), and first conveying belt (6) is equipped between the detection device (4) and injection molding equipment (2), and second conveying belt (7) is equipped between the detection device (4) and storage device (5);First conveying belt (6) and second conveying belt (7) are further equipped with handling device (8) for handling injection molding piece; The detection device (4) includes clamping structure (41) and detection structure (42);The clamping structure (41) includes clamping mounting bracket (411) and clamping assembly (412) arranged on the clamping mounting bracket (411);The detection structure (42) includes detection mounting bracket (421) and detection assembly (422) mounted on the detection mounting bracket (421), and the detection mounting bracket (421) is slidably connected to the clamping mounting bracket (411) by a displacement assembly (423);The detection assembly (422) includes a plurality of laser emitter groups arranged above the clamping assembly (412), and each laser emitter group includes a plurality of laser emitters (4221);The detection assembly (422) further includes a signal receiving plate (4222) arranged below the clamping assembly (412), and the signal receiving plate (4222) is provided with a plurality of photosensitive elements.

2. The microfluidic chip production line according to claim 1, wherein: The forming mould (1) includes upper die structure and lower die structure;The upper die structure includes upper die (11) and upper die fixing plate (12) for fixing the upper die (11);The upper die (11) is further provided with a liquid injection assembly (13) above;The lower die structure includes lower die (14) and lower die fixing plate (15) for mounting the lower die (14);The lower die fixing plate (15) is provided with a lower die base plate (16) below;The lower die base plate (16) and the lower die (14) are provided with a jacking assembly (17);The jacking assembly (17) is further provided with a lower die vertical plate (161) connected between the lower die fixing plate (15) and the lower die base plate (16) on both sides.

3. The production line of microfluidic chips according to claim 2, characterized in that: The bottom surface of the upper die (11) is provided with a male die (111);The upper die (11) is provided with a plurality of flow channels (112); The male die (111) is provided with a plurality of air holes (1111); The liquid injection assembly (13) includes a liquid injection plate (131) and a liquid distribution plate (132), the liquid injection plate (131) is connected with a liquid injection port (1311), and a funnel-shaped liquid injection port (13111) is formed in the liquid injection port (1311); The bottom of the liquid distribution plate (132) is embedded in the upper mold fixed plate (12); the top of the liquid distribution plate (132) is provided with a liquid inlet (1321) corresponding to the liquid injection port (13111), and the bottom of the liquid distribution plate (132) is respectively provided with a liquid outlet (1322) corresponding to each flow channel (112), and each liquid outlet (1322) is communicated to the liquid inlet (1321).

4. The microfluidic chip production line according to claim 2, wherein: The lower mold (14) is slidingly embedded in the lower mold fixed plate (15), and a plurality of first through holes (141) are arranged in the lower mold (14); The jacking assembly (17) comprises a jacking top plate (171) and a jacking bottom plate (172), and a plurality of guide columns (173) are arranged between the jacking top plate (171) and the jacking bottom plate (172); a second through hole (1711) is arranged on the jacking top plate (171) corresponding to each first through hole (141); A lifting plate (174) is further arranged between the jacking top plate (171) and the jacking bottom plate (172), and the lifting plate (174) is slidingly connected to the guide column (173); a top rod (1741) is arranged on the top surface of the lifting plate (174) corresponding to each second through hole (1711), and a lifting assembly (175) is arranged below the lifting plate (174); The lifting assembly (175) comprises a first transmission block (1751) fixed to the lifting plate (174) and a lifting driving element (1752) fixed to the jacking bottom plate (172), and a second transmission block (1753) for driving the first transmission block (1751) to lift is connected to the lifting driving element (1752); the first transmission block (1751) and the second transmission block (1753) are connected through a slope transmission; A spring (1754) is further arranged around the top rod (1741) above the lifting plate (174).

5. The microfluidic chip production line of claim 1, wherein: The detection assembly (422) and the detection mounting frame (421) are connected through a rotating seat (4251) and a rotating mounting strip (4252), the bottom surface of the rotating mounting strip (4252) is a plane, and a plurality of rows of laser emitter groups are mounted on the bottom surface of the rotating mounting strip (4252); One end of the rotating mounting strip (4252) is provided with a knob (4253); The bottom surface of the signal receiving plate (4222) is connected to the detection mounting frame (421) through a lifting structure (424) at both ends; The lifting structure (424) comprises a first rotating seat (4241) arranged on the detection mounting frame (421) and a plurality of second rotating seats (4242) arranged on the bottom surface of the signal receiving plate (4222); the first rotating seat (4241) is provided with a rotating block (4243), the rotating block (4243) is connected with an adjusting rod (4244), the adjusting rod (4244) is sleeved with a retreat-stop block (4245), the adjusting rod (4244) and the retreat-stop block (4245) are connected through threads, and the retreat-stop block (4245) is clamped in the rotating block (4243); the top end of the adjusting rod (4244) is connected with a lifting connecting piece (4246), and the lifting connecting piece (4246) is rotationally connected to the second rotating seat (4242); the bottom end of the adjusting rod (4244) is connected with a rotating disc (4247). The displacement assembly (423) comprises a plurality of second guide rails (4231) parallel to each other, and the second guide rails (4231) are provided with second sliding blocks (4232) connected with the detection mounting frame (421); the displacement assembly (423) further comprises a displacement driving element (4233) arranged between the detection mounting frame (421) and the clamping mounting frame (411). The displacement driving element (4233) is a linear motor.

6. The microfluidic chip production line of claim 1, wherein: The clamping assembly (412) comprises a clamping disc (4129) and two clamping strips (4121) parallel to each other, and a convex strip (4122) for lifting the microfluidic chip is arranged on the inner side of the two clamping strips (4121); the bottom of the clamping disc (4129) is provided with a rectangular light transmission window (4128); the clamping assembly (412) further comprises two first guide rails (4123) parallel to each other, and the two first guide rails (4123) are perpendicular to the clamping strips (4121); the two first guide rails (4123) are arranged at two ends of the light transmission window (4128) respectively, and each clamping strip (4121) is connected to the two first guide rails (4123) through a first sliding block (4124) respectively; Both ends of the clamping disc (4129) are also provided with clamping driving elements (4125), and the clamping driving elements (4125) are provided with driving sliding blocks (4126) corresponding to each clamping strip (4121), and the driving sliding blocks (4126) and the clamping strips (4121) are connected through driving connecting pieces (4127).

7. The microfluidic chip production line of claim 1, wherein: The conveying device (8) comprises a conveying track (81) arranged above the detection device (4), the first conveying belt (6) and the second conveying belt (7), and two conveying manipulators (82) are arranged on the conveying track (81).

8. The microfluidic chip production line of claim 1, wherein: The injection molding equipment (2) is a horizontal injection molding machine or a vertical injection molding machine.

9. The microfluidic chip production line of claim 1, wherein: The material taking device (3) is a three-axis manipulator.

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