Method and apparatus for controlling a freeze dryer, freeze dryer, storage medium

Abstract

The application relates to the technical field of freeze-drying, and discloses a method for controlling a freeze dryer, the freeze dryer comprising a drying chamber, a vacuum pump, a heating device and a weighing device, a freeze-drying object is subjected to freeze-drying in the drying chamber, the vacuum pump is used for vacuumizing the drying chamber, the weighing device is used for obtaining the weight of the freeze-drying object, and the heating device acts on the freeze-drying object; the method comprises the following steps: obtaining the weight of the freeze-drying object multiple times; calculating a weight change parameter of the freeze-drying object; and controlling the operation of the heating device according to the weight change parameter. The method for controlling the freeze dryer disclosed by the application can achieve good freeze-drying effects on freeze-drying objects in the case that the physical and chemical properties of the freeze-drying objects are unclear. The application further discloses a device for controlling a freeze dryer, a freeze dryer and a storage medium.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of freeze-drying, for example to a method and device for controlling a freeze-dryer, a freeze-dryer, and a storage medium. BACKGROUND

[0002] A freeze-dryer creates a vacuum low-temperature environment to sublimate the solid water in a freeze-drying object, thereby realizing dehydration and drying of the freeze-drying object. The freeze-drying object needs to be kept in a certain shape and internal structure by low temperature, and it is difficult for the freeze-drying object to provide sufficient sublimation latent heat for sublimation of the solid water at a low temperature. This will affect the freeze-drying effect of the freeze-drying object and increase the time required for freeze-drying.

[0003] In order to accelerate the freeze-drying process, a microwave vacuum freeze-drying device and a microwave vacuum freeze-drying method are disclosed in the related art. In the initial stage of drying, electric heating is used as the main way to provide sublimation latent heat to promote the sublimation of a large amount of water in the material. In the later stage of drying, sublimation is blocked, and microwave heating is used to provide sublimation latent heat. The method determines the real-time moisture content according to the initial moisture content and weight change of the material, and switches the electric heating and microwave heating according to the real-time moisture content. In the microwave heating stage, the heating of the microwave is adjusted according to the freeze-drying characteristics of the material according to a preset program.

[0004] In the process of implementing the embodiments of the present disclosure, it is found that at least the following problems exist in the related art:

[0005] The method controls the heating device based on the initial moisture content and freeze-drying characteristics of the material, and it is difficult to achieve good freeze-drying effect in the case where the physicochemical properties of the material are unknown or deviate.

[0006] It should be noted that the information disclosed in the above background section is only used to strengthen the understanding of the background of the present application, and therefore can include information that does not constitute prior art known to those of ordinary skill in the art. SUMMARY

[0007] To provide a basic understanding of some aspects of the disclosed embodiments, the following brief summary is given. The summary is not an overall description of the application, nor is it intended to identify key / important elements or delineate the scope of the embodiments, but as a prelude to the detailed description below.

[0008] The embodiments of the present disclosure provide a method and device for controlling a freeze-dryer, a freeze-dryer, and a storage medium, to achieve good freeze-drying effect on a freeze-drying object in the case where the physicochemical properties of the freeze-drying object are not clear.

[0009] In some embodiments, the freeze dryer comprises a drying chamber, a vacuum pump, a heating device and a weighing device, the freeze drying object is subjected to freeze drying in the drying chamber, the vacuum pump is used to vacuumize the drying chamber, the weighing device is used to obtain the weight of the freeze drying object, and the heating device acts on the freeze drying object; the method comprises: obtaining the weight of the freeze drying object multiple times; calculating a weight change parameter of the freeze drying object; and controlling the operation of the heating device according to the weight change parameter.

[0010] In some embodiments, the controlling the operation of the heating device according to the weight change parameter comprises: starting the heating device and determining the heat generation amount of the heating device according to the weight change parameter in the case that the weight change parameter is greater than or equal to a weight change threshold; or, turning off the heating device and turning off the vacuum pump in the case that the weight change parameter is less than the weight change threshold.

[0011] In some embodiments, after the determining the heat generation amount of the heating device according to the weight change parameter, the method further comprises: obtaining the temperature of the freeze drying object; and turning off the heating device in the case that the temperature of the freeze drying object is greater than a temperature threshold.

[0012] In some embodiments, after the determining the heat generation amount of the heating device according to the weight change parameter, the method further comprises: obtaining the temperature of the freeze drying object multiple times; and adjusting the heat generation amount of the heating device according to the temperature of the freeze drying object.

[0013] In some embodiments, the adjusting the heat generation amount of the heating device according to the change of the temperature of the freeze drying object comprises: decreasing the heat generation amount of the heating device in the case that the temperature of the freeze drying object increases; or, increasing the heat generation amount of the heating device in the case that the temperature of the freeze drying object decreases.

[0014] In some embodiments, the obtaining the weight of the freeze drying object multiple times comprises: starting the vacuum pump to vacuumize the drying chamber; and periodically obtaining the weight of the freeze drying object in the case that the vacuum pump is started for a preset time length.

[0015] In some embodiments, the calculating the weight change parameter of the freeze drying object comprises: k = m1-m2, wherein k is the weight change parameter, m1 is the weight of the freeze drying object obtained last time, and m2 is the weight of the freeze drying object obtained this time.

[0016] In some embodiments, the device for controlling the freeze dryer comprises a processor and a memory storing program instructions, the processor is configured to execute the above-mentioned method for controlling the freeze dryer when running the program instructions.

[0017] In some embodiments, the freeze dryer comprises a freeze dryer body, a vacuum pump, a heating device, a weighing device and the above-mentioned device for controlling the freeze dryer, wherein the freeze dryer body defines a drying chamber inside for placing the freeze-drying object; the vacuum pump is connected to the drying chamber for vacuumizing the drying chamber; the heating device is arranged on the freeze dryer body for providing sublimation heat for the solid water in the freeze-drying object; the weighing device is arranged on the freeze dryer body for obtaining the weight of the freeze-drying object; and the device for controlling the freeze dryer is installed on the freeze dryer body.

[0018] In some embodiments, the storage medium stores program instructions which, when executed, perform the above-mentioned method for controlling the freeze dryer.

[0019] The method and device for controlling the freeze dryer, the freeze dryer and the storage medium provided by the embodiments of the present disclosure can achieve the following technical effects:

[0020] 1. The weight change parameter for controlling the heating device is obtained according to the weight of the freeze-drying object, and the freeze dryer does not need to know the initial water content of the freeze-drying object or preinstall a freeze-drying program suitable for the freeze-drying object, so the use range of the freeze dryer is wider.

[0021] 2. The weight change parameter of the freeze-drying object is determined according to the weight of the freeze-drying object obtained multiple times, so the weight change parameter of the freeze-drying object is objective and accurate, and the control of the heating device by the freeze dryer is more accurate.

[0022] The foregoing general description and the following description are only exemplary and explanatory, and are not used to limit the present application. BRIEF DESCRIPTION OF DRAWINGS

[0023] One or more embodiments are exemplarily illustrated by corresponding drawings, which do not constitute limitation on the embodiments, elements with the same reference numerals in the drawings are shown as similar elements, the drawings do not constitute proportional limitation, and wherein:

[0024] Figure 1 is a structural schematic diagram of a freeze dryer provided by the embodiments of the present disclosure;

[0025] Figure 2 is a schematic diagram of a method for controlling a freeze dryer provided by the embodiments of the present disclosure;

[0026] Figure 3 is a schematic diagram of another method for controlling a freeze dryer provided by the embodiments of the present disclosure;

[0027] Figure 4 is a schematic diagram of another method for controlling a freeze dryer provided by the embodiments of the present disclosure;

[0028] Figure 5 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;

[0029] Figure 6 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;

[0030] Figure 7 is a schematic diagram of another method for controlling a freeze dryer provided by an embodiment of the present disclosure;

[0031] Figure 8 is a schematic diagram of a device for controlling a freeze dryer provided by an embodiment of the present disclosure;

[0032] Figure 9 is a structural schematic diagram of another freeze dryer provided by an embodiment of the present disclosure. DETAILED DESCRIPTION

[0033] In order to enable a more detailed understanding of the features and technical content of the embodiments of the present disclosure, the implementation of the embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings, which are only used for reference and do not limit the embodiments of the present disclosure. In the following technical description, in order to facilitate explanation, a plurality of details are provided to provide a full understanding of the disclosed embodiments. However, one or more embodiments can still be implemented without these details. In other cases, well-known structures and devices can be simplified to facilitate the drawings.

[0034] The terms "first", "second", and the like in the specification and claims of the embodiments of the present disclosure and the above-mentioned drawings are used to distinguish similar objects and do not necessarily have to describe a specific order or sequence. It should be understood that the data thus used can be interchanged under appropriate circumstances, so that the embodiments of the present disclosure described herein can be implemented. In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusion.

[0035] Unless otherwise specified, the term "a plurality of" means two or more.

[0036] In the embodiments of the present disclosure, the character " / " represents an "or" relationship between the objects before and after it. For example, A / B represents: A or B.

[0037] The term "and / or" is a description of the association relationship between the objects, which means that there can be three relationships. For example, A and / or B means: A or B, or, A and B, the three relationships.

[0038] The term "corresponding" can refer to an association relationship or a binding relationship. A and B correspond to each other means that there is an association relationship or a binding relationship between A and B.

[0039] The freeze dryer creates a vacuum low-temperature environment to sublimate the solid water in the freeze-dried object, thereby realizing the dehydration and drying of the freeze-dried object. The freeze-dried object needs to maintain a certain shape and internal structure through low temperature, and it is difficult for the freeze-dried object with low temperature to provide sufficient sublimation latent heat for the sublimation of the solid water. This will affect the freeze-drying effect of the freeze-dried object and increase the time required for freeze-drying.

[0040] In order to accelerate the freeze-drying process, a microwave vacuum freeze-drying device and a microwave vacuum freeze-drying method thereof are disclosed in the related art. In the initial stage of drying, electric heating is used as the main way to provide sublimation latent heat to promote the sublimation of a large amount of water in the material. In the later stage of drying, microwave heating is used to provide sublimation latent heat when sublimation is blocked. The method determines the real-time moisture content according to the initial moisture content and weight change of the material, and switches between electric heating and microwave heating according to the real-time moisture content. In the microwave heating stage, the heating of the microwave is adjusted according to the freeze-drying characteristics of the material according to a preset program. The problem of the related art is that the method controls the heating device based on the initial moisture content and freeze-drying characteristics of the material, and it is difficult to achieve good freeze-drying effect when the physicochemical properties of the material are unknown or deviate.

[0041] The method for controlling the freeze dryer provided by the embodiments of the present disclosure controls the operation of the heating device according to the weight change parameter, and good freeze-drying effect can be achieved even when the initial water content and other physicochemical properties of the freeze-dried object are unknown.

[0042] In combination Figure 1 As shown in the drawings, the embodiments of the present disclosure provide a freeze dryer, which includes a drying chamber 201, a vacuum pump 202, a heating device 203, and a weighing device 204. The freeze-dried object is freeze-dried in the drying chamber 201. The vacuum pump 202 is used to vacuumize the drying chamber 201. The weighing device 204 is used to obtain the weight of the freeze-dried object. The heating device 203 acts on the freeze-dried object.

[0043] The drying chamber is used to provide a drying environment for the freeze-dried object, and the drying chamber is a dense chamber. The vacuum pump is connected to the drying chamber, and the vacuum pump is used to vacuumize the drying chamber when the vacuum pump is running. The boiling point of the solid water in the freeze-dried object decreases in an environment with low air pressure, and is easy to sublimate into gaseous water. The gaseous water sublimation absorbs heat, and the heating device is used to supplement the heat for the freeze-dried object. The weighing device is used to obtain the weight of the freeze-dried object. Exemplarily, the weighing device is a weight sensor arranged in the drying chamber.

[0044] Using the freeze dryer provided by the embodiments of the present disclosure, the heating device can supplement the sublimation heat for the freeze-dried object, which can accelerate the freeze-drying process of the freeze-dried object. The weighing device can obtain the weight of the freeze-dried object, which can be used to judge the freeze-drying state of the freeze-dried object, and is conducive to the accurate freeze-drying control of the freeze dryer.

[0045] In combination Figure 2As shown, the embodiment of the present disclosure provides a method for controlling a freeze dryer, applied to the freeze dryer described above, the method comprising:

[0046] S01, the weighing device obtains the weight of the freeze-dried object multiple times.

[0047] S02, the freeze dryer calculates the weight change parameter of the freeze-dried object.

[0048] S03, the freeze dryer controls the operation of the heating device according to the weight change parameter.

[0049] The drying stage of freeze drying is generally divided into sublimation drying stage and desorption drying stage. The sublimation drying stage is also called primary drying, and the sublimation of solid water gradually moves from the outer surface of the freeze-dried object to the inside. The gap left after the sublimation of solid water serves as an escape channel for subsequent sublimation of solid water.

[0050] In the sublimation drying stage, the sublimation speed of solid water is different. In the initial stage of freeze drying, the sublimation speed of solid water is relatively fast. As freeze drying proceeds, the sublimation speed of solid water decreases, and at the end of freeze drying, the sublimation speed of solid water approaches zero.

[0051] The sublimation of solid water absorbs a certain amount of heat, and the heat stored in the freeze-dried object is limited, so it is difficult for solid water to absorb heat from the freeze-dried object, which affects the sublimation of solid water.

[0052] By providing sublimation heat for solid water through the heating device, the sublimation of solid water can be accelerated, thereby reducing the required time for freeze drying. However, turning on the heating device may cause the structure of the freeze-dried object to melt or collapse, affecting the freeze-drying effect.

[0053] Based on this, the control method for controlling the freeze dryer provided by the embodiment of the present disclosure starts from the perspective of the heat required for the sublimation of solid water, and controls the operation of the heating device according to the heat required for the sublimation of the freeze-dried object. Specifically, according to the sublimation speed of solid water, the freeze-dried object is supplemented with sublimation heat suitable for the sublimation speed. Turning on the heating device makes the freeze-dried object in a heat balance state, which accelerates the freeze-drying process while making the freeze-dried object obtain the expected freeze-drying effect.

[0054] The sublimation speed of solid water is not easy to measure, but as the sublimation of solid water proceeds, the weight of the freeze-dried object also changes. Therefore, the weight change parameter of the freeze-dried object is regarded as a synchronous indicator of the sublimation speed of solid water. For example, within a predetermined time period, if the weight change of the freeze-dried object is large, it is considered that the sublimation speed of solid water is fast, and if the weight change of the freeze-dried object is small, it is considered that the sublimation speed of solid water is slow.

[0055] According to the weight change parameter, the operation of the heating device can correspond to the sublimation speed of solid water in the freeze-dried object, thereby improving the freeze-drying effect and shortening the required time for freeze drying.

[0056] The weight change parameter of the freeze-drying object is calculated based on the weight of the freeze-drying object obtained multiple times. The initial weight, initial water content and other physicochemical properties of the freeze-drying object do not need to be known in advance. After the freeze-drying object is placed in the drying chamber, the freeze-drying machine can obtain the weight of the freeze-drying object multiple times and calculate the weight change parameter of the freeze-drying object, and control the operation of the heating device according to the weight change parameter.

[0057] Compared with the method in the related art, the method provided in the embodiments of the present disclosure can achieve good freeze-drying effect on any unknown type of freeze-drying object, while the type of material that can be freeze-dried by the method in the related art is limited by the limitation of the material type that can be freeze-dried by the built-in program. In the case where the initial water content of the material, the physicochemical parameters of the freeze-drying object and the like are unknown or the fluctuation of the material in different batches is large, the control will have certain deviation, while the control of the technical solution of the present application relies on the real-time weight of the current freeze-drying object, so the control is more stable.

[0058] Using the method for controlling the freeze-drying machine provided in the embodiments of the present disclosure, the weight change parameter for controlling the heating device is calculated based on the weight of the freeze-drying object, and the freeze-drying machine does not need to know the initial water content of the freeze-drying object or preinstall a freeze-drying program suitable for the freeze-drying object, so the use range of the freeze-drying machine is wider. The weight change parameter of the freeze-drying object is determined based on the weight of the freeze-drying object obtained multiple times, the weight change parameter of the freeze-drying object is objective and accurate, and the control of the heating device by the freeze-drying machine is more accurate.

[0059] In the related art, some freeze-drying machines use the temperature of the freeze-drying object as the main control means in the freeze-drying process, for example, the freeze-drying object is controlled to be kept at a preset temperature for a preset time, and the operation of the heating device is controlled according to the temperature change of the freeze-drying object, so that the freeze-drying object is kept at the preset temperature.

[0060] The problem of this control method is that the preset temperature needs to be preset first, and the use range of the freeze-drying machine is limited. In addition, the sublimation speed of the solid water in the freeze-drying object is limited by the preset temperature, and the freeze-drying effect is poor in the case where the temperature setting is unreasonable or has deviation.

[0061] The method for controlling the freeze-drying machine provided in the embodiments of the present disclosure controls the operation of the heating device through the weight change parameter of the freeze-drying object, so that the heat supplied by the heating device and the heat required for the sublimation of the solid water are dynamically balanced, and the temperature of the freeze-drying object is allowed to fluctuate to a certain extent. In this way, good freeze-drying effect can be achieved on the freeze-drying machine without knowing the preset temperature in advance, and the freeze-drying time is shortened.

[0062] In combination with Figure 3 As shown in FIG. 1, the embodiments of the present disclosure provide another method for controlling a freeze-drying machine, which comprises:

[0063] S01, the weighing device obtains the weight of the freeze-drying object multiple times.

[0064] S02, the freeze-drying machine calculates the weight change parameter of the freeze-drying object.

[0065] S31, in the case that the weight change parameter is greater than or equal to the weight change threshold, the freeze-drying machine starts the heating device and determines the heat quantity of the heating device according to the weight change parameter.

[0066] In the embodiments of the present disclosure, the weight change parameter is a state parameter of the freeze-drying process. In the case that the weight change parameter is greater than or equal to the weight change threshold, it is considered that the solid water in the freeze-drying object is still in continuous sublimation. At this time, the heating device is started to provide heat for the sublimation of the solid water, thereby accelerating the freeze-drying process. Further, the weight change parameter also represents the speed of the sublimation of the solid water. Therefore, the heat quantity of the heating device is determined according to the weight change parameter. In this way, the freeze-drying object can be in a relatively heat balance state in the freeze-drying process, and the expected freeze-drying effect can be achieved while accelerating the freeze-drying process. Exemplarily, the weight change threshold is between 0.1 and 1% of the first measured weight of the freeze-drying object. Such a weight change threshold can better reflect the freeze-drying state of the freeze-drying object.

[0067] Optionally, in the step S31 of starting the heating device in the case that the weight change parameter is greater than or equal to the weight change threshold and determining the heat quantity of the heating device according to the weight change parameter, the heat quantity of the heating device is determined by the following relationship:

[0068] Q=a*k

[0069] wherein Q is the heat quantity of the heating device, a is an adjustment coefficient, and k is the weight change parameter.

[0070] In the case that the weight change of the freeze-drying object is relatively large, the sublimation speed of the solid water is relatively fast, and the heat quantity of the heating device is relatively large; in the case that the weight change of the freeze-drying object is relatively small, the sublimation speed of the solid water is relatively slow, and the heat quantity of the heating device is relatively small. In this way, the freeze-drying object can be in a temperature balance state, thereby accelerating the freeze-drying process and achieving the expected freeze-drying effect.

[0071] Optionally, the value of the adjustment coefficient a is positively correlated with the latent heat required for the sublimation of the solid water per unit weight and is negatively correlated with the heat absorption rate of the freeze-drying object. In this way, the heat supplement of the freeze-drying machine to the freeze-drying object can be more accurate.

[0072] Optionally, in the case that the weight change parameter is greater than or equal to the weight change threshold, the freeze dryer starts the heating device and determines the heat generation of the heating device according to the weight change parameter, including: determining the target power of the heating device according to the heat generation of the heating device; gradually increasing the output power of the heating device to the target power.

[0073] In the case that the vacuum degree is relatively high, the freeze-drying object mainly receives heat through thermal radiation and heat transfer. In the freeze-drying object, the interface where sublimation occurs gradually moves from the outside to the inside. After the power of the heating device is increased, the heat may not be transferred to the inside of the freeze-drying object in time, which may cause the surface temperature of the freeze-drying object to be too high, thereby causing collapse or melting. Gradually increasing the power of the heating device provides a certain time for the conduction of heat in the freeze-drying object. Compared with the form of directly increasing the output power of the heating device to the target power, the risk of melting and collapse of the surface of the freeze-drying object is reduced, and the freeze-drying effect of the freeze-drying object is improved.

[0074] In combination Figure 4 As shown in the figure, the embodiment of the disclosure provides another method for controlling a freeze dryer, including:

[0075] S01, the weighing device obtains the weight of the freeze-drying object multiple times.

[0076] S02, the freeze dryer calculates a weight change parameter of the freeze-drying object.

[0077] S31, in the case that the weight change parameter is greater than or equal to the weight change threshold, the freeze dryer starts the heating device and determines the heat generation of the heating device according to the weight change parameter.

[0078] S32, in the case that the weight change parameter is less than the weight change threshold, the freeze dryer turns off the heating device and turns off the vacuum pump.

[0079] The weight change parameter is a state parameter of the freeze-drying process. In the case that the weight change parameter is less than the weight change threshold, it is considered that the sublimation of the solid water in the freeze-drying object is slow or no longer sublimates. At this time, there may be two cases, the first case is that the heat required for the sublimation of the solid water in the freeze-drying object is insufficient and the sublimation is blocked, and the second case is that the sublimation of the solid water in the freeze-drying object is completed and the freeze-drying ends. For the first case, the heat supplied by the heating device matches the heat required for the sublimation of the solid water, and a part of the heat accumulated by the freeze-drying object itself can also make the solid water sublimate. Therefore, the first case is excluded. Therefore, in the case that the weight change parameter is less than the weight change threshold, it is considered that the freeze-drying object has achieved the expected freeze-drying effect, and at this time, the heating device is turned off and the vacuum pump is turned off. In the embodiment of the disclosure, the case that the weight change parameter is less than the weight change threshold is taken as a judgment condition for the end of freeze-drying, and the judgment of the end of freeze-drying is more accurate.

[0080] In combinationFigure 5 As shown, the embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:

[0081] S01, the weighing device obtains the weight of the freeze-dried object multiple times.

[0082] S02, the freeze dryer calculates the weight change parameter of the freeze-dried object.

[0083] S31, in the case where the weight change parameter is greater than or equal to the weight change threshold, the freeze dryer starts the heating device and determines the heat output of the heating device according to the weight change parameter.

[0084] S41, the freeze dryer obtains the temperature of the freeze-dried object.

[0085] S42, in the case where the temperature of the freeze-dried object is greater than the temperature threshold, the freeze dryer turns off the heating device.

[0086] In the case where the heating device is not started, the temperature of the freeze-dried object will not change much. After starting the heating device, the temperature of the freeze-dried object may rise. In the case where the temperature of the freeze-dried object is greater than the temperature threshold, it is considered that the freeze-dried object has the risk of melting and collapsing. At this time, the heating device is turned off, so that the temperature of the freeze-dried object is within the preset interval.

[0087] Obtaining the temperature of the freeze-dried object is performed after starting the heating device, which can reduce the computational load of the freeze dryer. In the case where the temperature of the freeze-dried object is greater than the temperature threshold, the heating device is turned off, which can avoid the temperature of the freeze-dried object being too high, thereby obtaining the expected freeze-drying effect.

[0088] Optionally, the temperature threshold is the disintegration temperature of the freeze-dried object. Taking the disintegration temperature as the temperature threshold of the freeze-dried object can avoid the collapse of the surface of the freeze-dried object.

[0089] Optionally, the temperature threshold is determined according to the following relationship:

[0090] T=T0±c

[0091] Wherein, T is the temperature threshold, T0 is the temperature of the freeze-dried object when the heating device is started, and c is the temperature tolerance. Exemplarily, the value of c is 2. In this way, in the case where the disintegration temperature of the freeze-dried object is unknown, the freeze dryer can also have a good freeze-drying effect on the freeze-dried object.

[0092] In combination Figure 6 As shown, the embodiment of the present disclosure provides another method for controlling a freeze dryer, comprising:

[0093] S01, the weighing device obtains the weight of the freeze-dried object multiple times.

[0094] S02, the freeze dryer calculates the weight change parameter of the freeze-dried object.

[0095] S31, in the case where the weight change parameter is greater than or equal to the weight change threshold, the freeze dryer starts the heating device and determines the heat output of the heating device according to the weight change parameter.

[0096] S51, the freeze dryer acquires the temperature of the freeze-drying object multiple times.

[0097] S52, the freeze dryer adjusts the heat output of the heating device according to the temperature change of the freeze-drying object.

[0098] In the case where the heating device is not started, the temperature of the freeze-drying object will not change much. After the heating device is started, the temperature of the freeze-drying object may increase. It is necessary to control the temperature of the freeze-drying object. In the case where the temperature of the freeze-drying object is less than the temperature threshold, the freeze-drying object is not at risk of collapse or melting. At this time, the more heat provided by the heating device, the more sufficient the sublimation of solid water in the freeze-drying object. Therefore, it is necessary to control the temperature of the freeze-drying object within an interval below the temperature threshold. After the heat output of the heating device is determined according to the weight change parameter, the heat output of the heating device is corrected according to the temperature change of the freeze-drying object. In this way, the heat output of the heating device is accurately controlled, and the freeze-drying speed of the freeze-drying object is improved while ensuring that the freeze-drying object will not collapse or melt.

[0099] Optionally, step S52, adjusting the heat output of the heating device according to the temperature of the freeze-drying object comprises: in the case where the temperature of the freeze-drying object increases, reducing the heat output of the heating device; in the case where the temperature of the freeze-drying object decreases, increasing the heat output of the heating device.

[0100] In the case where the temperature of the freeze-drying object increases, the heating device supplies more heat output, which may cause the temperature of the freeze-drying object to further increase, and at this time, the heat output of the freeze-drying object is reduced. In the case where the temperature of the freeze-drying object decreases, the heating device supplies less heat output, which may cause the temperature of the freeze-drying object to be low and the sublimation of solid water to be weakened, and at this time, the heat output of the freeze-drying object is increased. In this way, the temperature of the freeze-drying object can always be in a suitable temperature interval.

[0101] In combination with Figure 7 the accompanying drawings, the present disclosure provides another method for controlling a freeze dryer, comprising:

[0102] S11, the freeze dryer starts a vacuum pump to pump the drying chamber.

[0103] S12, in the case where the vacuum pump is started for a preset time length, the freeze dryer periodically acquires the weight of the freeze-drying object.

[0104] S02, the freeze dryer calculates a weight change parameter of the freeze-drying object.

[0105] S03, the freeze-drying machine controls the operation of the heating device according to the weight change parameter.

[0106] In the initial stage of the vacuum pump starting, the vacuum degree of the drying chamber gradually increases. In this process, the sublimation speed of the solid water in the freeze-drying object gradually increases. With the increase of the vacuum degree and the internal migration of the sublimation surface in the freeze-drying object, the sublimation speed of the solid water gradually decreases. If the weight of the freeze-drying object is obtained too early, it is possible to cause the freeze-drying machine to misjudge the freeze-drying process of the freeze-drying object. For example, in the initial stage of the vacuum pump starting, the weight of the freeze-drying object changes little or not at all. According to the weight change alone, the freeze-drying machine is prone to think that the freeze-drying of the freeze-drying object is close to completion. Therefore, the weight of the freeze-drying object is periodically obtained after the vacuum pump starting reaches a preset time length. In this way, the freeze-drying machine can avoid misjudgment of the freeze-drying process, and improve the reliability of the freeze-drying machine in controlling the freeze-drying.

[0107] Optionally, in step S02, the freeze-drying machine calculates the weight change parameter of the freeze-drying object, and the weight change parameter of the freeze-drying machine is calculated according to the following formula:

[0108] k = m1 - m2,

[0109] wherein k is the weight change parameter, m1 is the weight of the freeze-drying object obtained last time, and m2 is the weight of the freeze-drying object obtained this time.

[0110] The weight change parameter is a quantity characterizing the loss speed of the solid water in the freeze-drying object. In the case of obtaining the weight of the freeze-drying object multiple times, the difference between the weight obtained last time and the weight obtained this time can well reflect the sublimation amount of the solid water. In the case of periodically obtaining the weight of the freeze-drying object, the difference between the weight obtained last time and the weight obtained this time can also characterize the sublimation speed of the solid water. Therefore, taking the difference between the weight of the freeze-drying object obtained last time and the weight of the freeze-drying object obtained this time as the weight change parameter can enable the freeze-drying machine to more accurately control the heating device.

[0111] Optionally, in step S02, the freeze-drying machine calculates the weight change parameter of the freeze-drying object, and the weight change parameter of the freeze-drying machine is calculated according to the following formula:

[0112] k = (m1 - m2) / m1

[0113] wherein k is the weight change parameter, m1 is the weight of the freeze-drying object obtained last time, and m2 is the weight of the freeze-drying object obtained this time.

[0114] With such a parameter form, the weight change parameter is a ratio, which facilitates the correlation calculation with the heat generation amount of the heating device while reflecting the sublimation amount and sublimation speed of the solid water.

[0115] Optionally, in the step S02, the freeze-drying machine calculates the weight change parameter of the freeze-drying object, and the weight change parameter of the freeze-drying machine is calculated according to the following formula:

[0116] k = (m1-m2) / t

[0117] wherein, k is the weight change parameter, m1 is the weight of the freeze-drying object obtained last time, m2 is the weight of the freeze-drying object obtained this time, and t is the time interval between the last time of measuring the weight of the freeze-drying object and the current time of measuring the weight of the freeze-drying object.

[0118] In the case that the weight of the freeze-drying object is obtained in a non-periodic manner, the introduction of the time interval t can make the weight change parameter k better reflect the sublimation speed of the solid water.

[0119] In combination with Figure 8 As shown in FIG. 1, the device 10 for controlling the freeze-drying machine provided by the embodiments of the present disclosure includes a processor 100 and a memory 101. Optionally, the device can further include a communication interface 102 and a bus 103. The processor 100, the communication interface 102 and the memory 101 can complete mutual communication through the bus 103. The communication interface 102 can be used for information transmission. The processor 100 can invoke the logic instructions in the memory 101 to execute the method for controlling the freeze-drying machine of the above-mentioned embodiments.

[0120] In addition, the logic instructions in the memory 101 can be implemented in the form of a software function unit and sold or used as an independent product, which can be stored in a computer readable storage medium.

[0121] The memory 101 as a computer readable storage medium can be used to store software programs, computer executable programs, such as program instructions / modules corresponding to the method in the embodiments of the present disclosure. The processor 100 executes the program instructions / modules stored in the memory 101, thereby performing function applications and data processing, i.e. implementing the method for controlling the freeze-drying machine in the above-mentioned embodiments.

[0122] The memory 101 can include a program storage area and a data storage area, wherein the program storage area can store an operating system and at least one application required by a function; the data storage area can store data created according to the use of the terminal device, etc. In addition, the memory 101 can include a high-speed random access memory, and can also include a non-volatile memory.

[0123] In combination with Figure 1 , Figure 9As shown, the embodiment of the present disclosure provides a freeze dryer, comprising: a freeze dryer body 20, and the device 10 for controlling the freeze dryer described above. The device 200 for controlling the freeze dryer is installed on the freeze dryer body. The installation relationship described herein is not limited to being placed inside the product, but also includes installation connection with other components of the product, including but not limited to physical connection, electrical connection or signal transmission connection, etc. Those skilled in the art can understand that the device 10 for controlling the freeze dryer can be adapted to the feasible product body, and thus realize other feasible embodiments.

[0124] The embodiment of the present disclosure provides a computer readable storage medium, which stores computer executable instructions, and the computer executable instructions are configured to execute the method for controlling the freeze dryer.

[0125] The computer readable storage medium described above can be a transitory computer readable storage medium or a non-transitory computer readable storage medium.

[0126] The technical solution of the embodiment of the present disclosure can be embodied in the form of a software product. The computer software product is stored in a storage medium and includes one or more instructions to make a computer device (which can be a personal computer, a server, or a network device, etc.) execute all or part of the steps of the method of the embodiment of the present disclosure. The aforementioned storage medium can be a non-transitory storage medium, including a U disk, a mobile hard disk, a read-only memory (ROM, Read-Only Memory), a random access memory (RAM, Random Access Memory), a magnetic disk or an optical disk, and various media that can store program codes, or a transitory storage medium.

[0127] The foregoing description and accompanying drawings fully illustrate embodiments of this disclosure to enable those skilled in the art to practice them. Other embodiments may include structural, logical, electrical, procedural, and other changes. The embodiments represent only possible variations. Individual components and functions are optional unless explicitly required, and the order of operation may vary. Parts and features of some embodiments may be included in or replace parts and features of other embodiments. Moreover, the terminology used in this application is for describing embodiments only and is not intended to limit the claims. As used in the description of embodiments and claims, the singular forms “a,” “an,” and “the” are intended to equally include the plural forms unless the context clearly indicates otherwise. Similarly, the term “and / or” as used in this application means including one or more of the associated listed items and all possible combinations thereof. Additionally, when used in this application, the term "comprise" and its variations "comprises" and / or "comprising" refer to the presence of stated features, integrals, steps, operations, elements, and / or components, but do not exclude the presence or addition of one or more other features, integrals, steps, operations, elements, components, and / or groups thereof. Without further limitations, an element defined by the phrase "comprises a..." does not exclude the presence of other identical elements in the process, method, or apparatus that includes said element. In this document, each embodiment may focus on the differences from other embodiments, and similar or identical parts between embodiments can be referred to mutually. For methods, products, etc., disclosed in the embodiments, if they correspond to the method section disclosed in the embodiments, the relevant parts can be referred to the description of the method section.

[0128] Those skilled in the art will recognize that the units and algorithm steps of the various examples described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are implemented in hardware or software depends on the specific application and design constraints of the technical solution. Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of the embodiments of this disclosure. Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the specific working processes of the systems, devices, and units described above can be referred to the corresponding processes in the foregoing method embodiments, and will not be repeated here.

[0129] In the embodiments disclosed herein, the disclosed methods, products (including but not limited to apparatuses, devices, etc.) can be implemented in other manners. For example, the described apparatus embodiments can be implemented only in a form of a logical function, and can be implemented by using a manner such as software (for example, a computer program) or a combination of hardware and software. In some embodiments, a plurality of units or components can be combined or integrated into another system, or some features can be ignored or not executed. In addition, the displayed or discussed mutual couplings or direct couplings or communication connections can be implemented by using some interfaces, and a mere combination of the described or illustrated elements can not necessarily be a logical or physical couplings. In addition, the displayed or discussed elements or the actual used elements can be divided into physical or logical parts, and can be combined or integrated into another system. In some embodiments, the display or discussion of a plurality of times of the elements can be combined or integrated into a same element. In some embodiments, the actual implementation can be different from the description in the specific uses or implementation process. In some embodiments, the elements or components of the embodiments disclosed herein can be implemented in software or other functional entities, and can be stored in any type of volatile or non-volatile storage medium according to data storage technologies. For example, the storage medium can be a semiconductor memory, a magnetic disk, an optical disk, or the like.

[0130] The flowcharts and block diagrams in the drawings show the possible implementation architectures, functions and operations of the system, method and computer program product according to the embodiments of the present disclosure. In this regard, each block in the flowcharts or block diagrams can represent a module, a program segment or a part of code that contains one or more executable instructions for implementing the specified logical functions. In some alternative implementations, the functions noted in the blocks can occur in different orders than those noted in the drawings. For example, two consecutive blocks can actually be executed substantially in parallel, and they can sometimes be executed in reverse order, depending on the functions involved. In the descriptions corresponding to the flowcharts and block diagrams in the drawings, the operations or steps corresponding to different blocks can also occur in different orders from those disclosed in the descriptions, and sometimes there is no specific order between different operations or steps. For example, two consecutive operations or steps can actually be executed substantially in parallel, and they can sometimes be executed in reverse order, depending on the functions involved. Each block in the block diagrams and / or flowcharts, and the combination of blocks in the block diagrams and / or flowcharts, can be implemented by a dedicated hardware-based system that performs the specified functions or actions, or can be implemented by a combination of dedicated hardware and computer instructions.

Claims

1. A method for controlling a freeze-dryer, characterized in that, The freeze dryer comprises a drying chamber, a vacuum pump, a heating device and a weighing device, the freeze-drying object is freeze-dried in the drying chamber, the vacuum pump is used to vacuumize the drying chamber, the weighing device is used to obtain the weight of the freeze-drying object, and the heating device acts on the freeze-drying object; the method comprises: Obtaining the weight of the freeze-drying object multiple times; Calculating the weight change parameter of the freeze-drying object; Controlling the operation of the heating device according to the weight change parameter; The control of the operation of the heating device according to the weight change parameter comprises: Starting the heating device and determining the heat output of the heating device according to the weight change parameter in the case that the weight change parameter is greater than or equal to a weight change threshold; or, Turning off the heating device and the vacuum pump in the case that the weight change parameter is less than the weight change threshold.

2. The method of claim 1, wherein, After the determination of the heat output of the heating device according to the weight change parameter, the method further comprises: Obtaining the temperature of the freeze-drying object; Turning off the heating device in the case that the temperature of the freeze-drying object is greater than a temperature threshold.

3. The method of claim 1, wherein, After the determination of the heat output of the heating device according to the weight change parameter, the method further comprises: Obtaining the temperature of the freeze-drying object multiple times; Adjusting the heat output of the heating device according to the temperature of the freeze-drying object.

4. The method of claim 3, wherein, The adjustment of the heat output of the heating device according to the change of the temperature of the freeze-drying object comprises: In the case that the temperature of the freeze-drying object increases, reducing the heat output of the heating device; or, In the case that the temperature of the freeze-drying object decreases, increasing the heat output of the heating device.

5. The method according to any one of claims 1 to 4, characterized in that, The multiple times of obtaining the weight of the freeze-drying object comprise: Starting the vacuum pump to vacuumize the drying chamber; Periodically obtaining the weight of the freeze-drying object in the case that the vacuum pump is started for a preset time length.

6. The method according to any one of claims 1 to 4, characterized in that, The calculation of the weight change parameter of the freeze-drying object comprises: k = m1 - m2, Wherein, k is the weight change parameter, m1 is the weight of the freeze-drying object obtained last time, and m2 is the weight of the freeze-drying object obtained this time.

7. An apparatus for controlling a freeze dryer, comprising a processor and a memory having stored program instructions, characterized in that, The processor is configured to execute the method for controlling the freeze dryer as claimed in any one of claims 1 to 6 when the program instructions are executed.

8. A freeze dryer characterized by, Comprise: The freeze dryer body defines a drying chamber inside, and the drying chamber is used to place the freeze-drying object; The vacuum pump is connected to the drying chamber and is used to vacuumize the drying chamber; The heating device is arranged on the freeze dryer body and is used to provide sublimation heat for the solid water in the freeze-drying object; The weighing device is arranged on the freeze dryer body and is used to obtain the weight of the freeze-drying object; and The device for controlling the freeze dryer as claimed in claim 7 is installed on the freeze dryer body.

9. A storage medium storing program instructions, characterized in that, The program instructions are executed to perform the method for controlling the freeze dryer as claimed in any one of claims 1 to 6.

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