Composition with water-oil coordinating effect and application thereof

Abstract

The present invention relates to the field of cosmetic technology, and in particular to a composition with water-oil harmonizing effect and its application. The composition with water-oil harmonizing effect comprises 0.5 to 3 parts of red pine lactone and 1 to 10 parts of schizonepeta biflavonoids by weight. The composition of the present invention, by using the two components of red pine lactone and schizonepeta biflavonoids in combination, has a synergistic effect, can significantly improve the regulating effect on oils and fats, and achieve the effect of water-oil harmonizing; the composition of the present invention can be used as a raw material for water-oil harmonizing effect in cosmetic products, and can significantly improve the water-oil harmonizing effect of cosmetic products.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, and in particular to a composition with water-oil blending effect and application thereof. Background Art

[0002] People with oily skin have troubles such as greasy skin, and the root cause of oily skin is the vigorous secretion of sebaceous glands, which leads to excessive oil on the surface of the skin, bringing an unrefreshing feeling. Therefore, people with oily skin will improve it by using oil control products or medical beauty projects, but these methods are often irritating to the skin, and will also exfoliate the keratin and make the skin barrier thinner, and the skin will become sensitive over time. And for oily skin that has already developed sensitive problems, common oil control products are not suitable. Therefore, there is a need for a composition that can play a role in water and oil coordination, which is more suitable for oily skin to regulate skin condition.

[0003] Pinusolid is a sesquiterpenoid compound. Pinusolid is a known platelet-activating factor (PAF) receptor binding antagonist that can inhibit the production of 5-lipoxygenase-dependent leukotriene C4 by blocking the c-Jun N-terminal kinase pathway. It can also attenuate the neurotoxic effects of staurosporine in primary cultures of rat cortical cells and may have a certain effect on the treatment of neurodegenerative diseases. The chemical structure of pinusolid is shown below:

[0004]

[0005] Studies have shown that red pine lactone has the effects of improving insulin resistance caused by hyperglycemia, anti-leukemia, anti-inflammatory, and neuroprotection.

[0006] Amentoflavone, also known as amentoflavone, is a flavonoid substance with a molecular formula of C 30 H 18 O 10 , molecular weight 538.46, melting point 256 ℃, is a C 30 Connected apigenin dimer. The chemical structure of the flavonoid pine lactone from the edible cedar is shown below:

[0007]

[0008] The main pharmacological activities of sedge flavonoids are antioxidant, anti-inflammatory and antibacterial. In the current research on sedge flavonoids, its targets are mainly NOX, ROS, SOD, glutathione reductase (GR), catalase (CAT) and glutathione peroxidase (GSH-Px) activities; inhibiting superoxide anion O2 ·-It can inhibit the production of lipid peroxide malondialdehyde (MDA); inhibit nuclear factor-кB (NF-кB) and mitogen-activated protein kinase (MAPK) signaling pathways; inhibit the receptor of TLR4, mediate the expression of iNOS and COX-2, and then inhibit inflammatory and oxidative stress pathways such as NO, PGE2, tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). However, there are few studies on the pharmacological activities in other directions, which greatly limits the application of sedge biflavonoids.

[0009] In view of this, the present invention is proposed. Summary of the invention

[0010] One object of the present invention is to provide a composition with water-oil harmonizing effect, which has the effect of harmonizing water and oil for oily sensitive skin by using two ingredients, red pine lactone and sedum biflavonoids, in combination.

[0011] Another object of the present invention is to provide a composition having water-oil blending effect for use in preparing cosmetic products.

[0012] In order to achieve the above-mentioned object of the present invention, the present invention provides a composition with water-oil coordination effect, comprising 0.5-3 parts of red pine lactone and 1-10 parts of sedum biflavonoids by weight.

[0013] In a specific embodiment of the present invention, the composition with water-oil coordination effect comprises 0.5-2 parts of red pine lactone and 3-7 parts of aconitum biflavonoids by weight.

[0014] In a specific embodiment of the present invention, the composition with water-oil coordination effect comprises 0.8-1.2 parts of red pine lactone and 4-6 parts of aconitum biflavonoids by weight.

[0015] In a specific embodiment of the present invention, the composition with water-oil coordination effect comprises 1 part of red pine lactone and 5 parts of aconitum biflavonoids by weight.

[0016] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination further comprises a solvent. Further, the solvent comprises any one or more of butanediol, hexanediol, propylene glycol, glycerol and n-butanol.

[0017] In a specific embodiment of the present invention, in the composition having the effect of water-oil coordination, the total mass concentration of the red pinolide and the aconitum biflavonoids is 0.3% to 50%.

[0018] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination includes any one of a liquid preparation and an ointment.

[0019] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination further comprises a functional additive; the functional additive comprises at least one of an emulsifier, a softener and a conditioner.

[0020] Another aspect of the present invention provides use of any one of the above-mentioned compositions with water-oil blending effects in the preparation of cosmetics.

[0021] In a specific embodiment of the present invention, the cosmetics include any one or more of cleansing milk, lotion, cream, ointment, essence and hair care products.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] (1) The composition with the effect of regulating water and oil of the present invention has a synergistic effect by using two components, namely, red pine lactone and sedum biflavonoids, which can significantly improve the regulating effect on oil and fat and achieve the effect of regulating water and oil;

[0024] (2) The composition with water-oil blending effect of the present invention can be used as a water-oil blending effect raw material in cosmetic products, and can significantly improve the water-oil blending effect of the cosmetic products. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0026] Figure 1 This is the dose-effect curve of finasteride's inhibitory effect on 5α-reductase;

[0027] Figure 2 The 5α-reductase inhibition dose-effect curves of the samples of Example 1, Comparative Example 1 and Comparative Example 2;

[0028] Figure 3 The changes in oil secretion over 28 days using different groups of samples;

[0029] Figure 4 The figure shows the changes in water loss rate of different groups of samples over 28 days. DETAILED DESCRIPTION

[0030] The technical scheme of the present invention will be clearly and completely described below in conjunction with the accompanying drawings and specific embodiments, but it will be understood by those skilled in the art that the following described embodiments are part of embodiments of the present invention, rather than all embodiments, and are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of the present invention. If specific conditions are not specified in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer is not specified in the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0031] The present invention provides a composition with water-oil coordination effect, comprising 0.5-3 parts of red pine lactone and 1-10 parts of schizonepeta biflavonoids by weight.

[0032] Generally speaking, the skin barrier of oily skin will be thicker, and deep cleaning is very suitable. Due to the greasy skin and skin problems such as blackheads and acne caused by the vigorous secretion of sebaceous glands, people with oily skin often use excessive cleaning methods to wash away the grease on the surface of the skin. Oil-control skin care products often contain ingredients such as retinoic acid and salicylic acid. In addition, there are also medical beauty projects such as acid brushing, photorejuvenation, and laser, which are also commonly used by people with oily skin to improve oil secretion. However, these methods are irritating to the skin, and the skin barrier often sounds an alarm before improving oil secretion. The skin will become sensitive, red, and dry, and the root problem of vigorous oil secretion has not been solved. And if oily sensitive skin continues to use conventional oil control products or excessive cleaning, it is easy to cause the skin to become more and more sensitive, and the inflammatory state and histamine secretion caused by sensitivity will be further aggravated. Based on this, the composition of the present invention can provide a reliable method for improving skin condition and achieving water-oil synchronization for oily sensitive skin.

[0033] The flavonoids of tachyphylla have a certain regulatory effect on the oil secretion of the skin, while the control ability of red pine lactone on the oil secretion of the skin is not obvious. The present invention adopts the two ingredients of red pine lactone and flavonoids of tachyphylla in combination, which has a synergistic effect, can significantly improve the regulatory effect on the oil secretion of the skin, and achieve the effect of water-oil coordination.

[0034] Water-oil balancing refers to regulating the skin's water content while regulating oil secretion, so that the oil content and water content on the skin surface reach a relatively balanced state. However, unlike the water-oil balanced cosmetics on the market, water-oil balance is usually adjusted for the imbalance of water and oil in healthy skin. The imbalance of water and oil in different skin types is often different, so targeted formulations are required. Water-oil balancing can save the step of formulating for different skin types, and is more universal. It can adjust the imbalance of water and oil in healthy or sensitive skin.

[0035] For example, in different embodiments, the composition with water-oil harmonizing effect may exemplarily include 0.5 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts or any two of the above mentioned pine lactones by weight, and may exemplarily include 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts or any two of the above mentioned pine flavonoids by weight.

[0036] In a specific embodiment of the present invention, in the composition having the effect of water-oil coordination, the mass ratio of the red pine lactone to the aconitum biflavonoids is less than 1.

[0037] In a specific embodiment of the present invention, the composition with water-oil coordination effect comprises 0.5-2 parts of red pine lactone and 3-7 parts of aconitum biflavonoids by weight.

[0038] In a specific embodiment of the present invention, the composition with water-oil coordination effect comprises 0.8-1.2 parts of red pine lactone and 4-6 parts of aconitum biflavonoids by weight.

[0039] In a specific embodiment of the present invention, the composition with water-oil coordination effect comprises 1 part of red pine lactone and 5 parts of aconitum biflavonoids by weight.

[0040] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination further comprises a solvent. Further, the solvent comprises any one or more of butanediol, hexanediol, propylene glycol, glycerol and n-butanol, such as 1,3-butanediol.

[0041] In a specific embodiment of the present invention, in the composition having the effect of water-oil coordination, the total mass concentration of the red pinolide and the aconitum biflavonoids is 0.3% to 50%.

[0042] For example, in different embodiments, in the composition with water-oil coordination effect, the total mass concentration of the red pine lactone and the sedge flavonoids can be exemplified as 0.3%, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50% or a range consisting of any two of them.

[0043] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination also includes a functional additive; the functional additive includes at least one of an emulsifier, a softener and a conditioner. Further, the composition having the effect of water-oil coordination includes 0.01 to 3 parts of the functional additive by weight.

[0044] Among them, the emulsifier may include C10-18 fatty acid triglycerides, C10-30 acid cholesterol / lanosterol mixed esters, PEG / PPG-1 / 2 copolymers, PEG / PPG-8 / 3 laurate, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerol, PEG-10 glyceryl isostearate, PEG-40 lanolin, PEG-100 lanolin, PEG-100 stearate, PEG-11 avocado glycerides, PEG-12 carnauba wax, PEG-15 coconut oil polyamine, PEG-15 stearate, PEG-192 almond glycerides, PEG-2 soyamine, PEG-2 anhydrous sorbitan isostearate, PEG-2 stearamine, PEG-3 cocamide, PEG-6 beeswax, PEG-7 laurate, PPG-1-cetyl alcohol polyamine At least one of ethers, PPG-9 glyceryl ether, PEG-10 hydrogenated castor oil, PEG-100 hydrogenated castor oil, PEG-2 hydrogenated castor oil, PEG-20 castor oil, PEG-200 castor oil, PEG-200 hydrogenated castor oil, PEG-25 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-35 castor oil, PEG-35 hydrogenated castor oil, PEG-36 castor oil, PEG-40 castor oil, PEG-40 hydrogenated castor oil, PEG-45 hydrogenated castor oil, PEG-5 hydrogenated castor oil, PEG-50 castor oil, PEG-50 hydrogenated castor oil, PEG-60 castor oil, PEG-60 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-8 hydrogenated castor oil, and PEG-80 hydrogenated castor oil;

[0045] The emollient may include at least one of C10-40 isoalkanoic acid cholesterol esters, C10-40 isoalkanoic acid triglycerides, C11-12 isoparaffins, N-palmitoyl hydroxyproline cetyl ester, PEG-9 diglycidyl ether / sodium hyaluronate crosspolymer, babassu seed oil, white lupine seed oil, castor oil, soybean oil, tea seed oil, canola oil, lilac flower oil, clove leaf oil, raspberry seed oil, synthetic jojoba oil, calendula flower oil, bitter orange flower oil, babassu seed oil, and Brazilian nectarine oil;

[0046] The conditioning agent may include at least one of safflower seed oil, red bisabolol oil, pepper fruit oil, pepper seed oil, jojoba seed oil, bitter almond oil, bitter orange peel oil, myrrh oil, rose flower oil, palmarosa oil, Ningxia wolfberry seed oil, lemon peel oil, apple seed oil, grape leaf oil, grape seed oil, grapefruit peel oil, grapefruit oil, grapefruit seed oil, ginseng seed oil, Japanese cypress wood oil, Japanese cypress oil, almond oil, oat germ oil, oat kernel oil, lavender oil, perilla seed oil, palm kernel oil, and palm oil.

[0047] The dosage form of the composition with water-oil coordination effect of the present invention can be adjusted according to actual product requirements, such as liquid preparations or ointments, etc. The types of functional additives required for different dosage forms can be adjusted according to actual conditions.

[0048] In a specific embodiment of the present invention, the composition having the effect of water-oil coordination comprises the following components in parts by mass:

[0049] 0.5 to 3 parts of red pine lactone, 1 to 10 parts of aconitum biflavonoids, 5 to 15 parts of alcohol solvents and 0.01 to 3 parts of functional additives.

[0050] The preparation method of the composition having the effect of water-oil coordination of the present invention comprises the following steps:

[0051] The korania lactone is mixed with a solvent to prepare a korania lactone solution; and the aconitum biflavonoids is added into the korania lactone solution and mixed evenly.

[0052] In a specific embodiment of the present invention, in the preparation of the rosin lactone solution, the rosin lactone and the solvent are heated and mixed at 45°C.

[0053] In a specific embodiment of the present invention, if the combination contains a functional additive, the functional additive and aconitum biflavonoids are simultaneously added to the koreanolide solution and mixed evenly.

[0054] In a specific embodiment of the present invention, after the mixing, the process further comprises shaking in a water bath for 1 to 2 hours.

[0055] Another aspect of the present invention provides use of any one of the above-mentioned compositions with water-oil blending effects in the preparation of cosmetics.

[0056] In a specific embodiment of the present invention, the cosmetics include any one or more of cleansing milk, lotion, cream, ointment, essence and hair care products.

[0057] Example 1

[0058] This embodiment provides a composition having the function of water-oil coordinating, comprising the following components by mass:

[0059] 1 part of red pinolactone, 5 parts of aconitum biflavonoids, 12 parts of 1,3-butylene glycol and 2 parts of PEG-40 castor oil.

[0060] The preparation method of the composition having the effect of water-oil coordination comprises the following steps:

[0061] The red pine lactone and 1,3-butanediol are mixed, and heated at 45°C for 15 minutes to obtain a red pine lactone solution; then, the sedge flavonoids and functional additives are added to the red pine lactone solution, mixed evenly, placed in a 37°C water bath constant temperature oscillator, and oscillated in a water bath for 2 hours to obtain the composition with water-oil coordinating effect.

[0062] Example 2

[0063] This embodiment provides a composition having the function of water-oil coordinating, comprising the following components in parts by mass:

[0064] 0.5 parts of red pinolactone, 5 parts of aconitum biflavonoids, 5 parts of 1,3-butylene glycol and 1 part of PEG-40 castor oil.

[0065] The preparation method of the composition having the effect of water-oil coordination can refer to the preparation method of Example 1.

[0066] Example 3

[0067] This embodiment provides a composition having the function of water-oil coordination, comprising the following components by mass:

[0068] 3 parts of red pinolactone, 1 part of aconitum biflavonoids, 12 parts of 1,3-butylene glycol and 0.5 parts of PEG-40 castor oil.

[0069] The preparation method of the composition having the effect of water-oil coordination can refer to the preparation method of Example 1.

[0070] Comparative Example 1

[0071] Comparative Example 1 is a sample of red pine lactone.

[0072] The preparation method of the red pine lactone sample includes: mixing 1 part of red pine lactone, 2 parts of 1,3-butanediol and 0.3 parts of PEG-40 castor oil by weight, heating at 45°C for 15 minutes to obtain a red pine lactone solution; then placing it in a 37°C water bath constant temperature oscillator, oscillating in a water bath for 2 hours to obtain the red pine lactone sample.

[0073] Comparative Example 2

[0074] Comparative Example 2 is a sample of Metasequoia glyptostroboides flavonoids.

[0075] The preparation method of the tachyphylla biflavonoids sample includes: mixing 1 part of tachyphylla biflavonoids, 2 parts of 1,3-butanediol and 0.3 parts of PEG-40 castor oil by weight, heating at 45°C for 15 minutes to obtain a tachyphylla biflavonoids solution; then placing it in a 37°C water bath constant temperature oscillator, oscillating in the water bath for 2 hours to obtain the tachyphylla biflavonoids sample.

[0076] Experimental Example 1

[0077] Inhibition of 5α-reductase

[0078] Sample preparation: Take the composition with water-oil coordinating effect of Example 1, the red pine lactone sample of Comparative Example 1, and the schizonepeta biflavonoids sample of Comparative Example 2;

[0079] Ten test concentrations were set respectively: 35 mg / mL was used as the initial concentration, and 9 2.5-fold gradient dilutions were made using a 20% ethanol aqueous solution; and 5 2-fold gradient dilutions were made using anhydrous ethanol for the positive control substance finasteride. The preparation of the sample with an initial concentration of 35 mg / mL included: dissolving the composition of Example 1 in a 20% ethanol aqueous solution to obtain a sample of the composition of Example 1 with a concentration of 35 mg / mL.

[0080] Mouse liver was dissected and homogenized by adding Tris buffer at a ratio of 1:5 at 0℃, centrifuged at 4℃, 10000g for 15min, and the supernatant was centrifuged at 0℃, 55000g for 1h, and then the supernatant was collected and placed at 4℃ for later use. Reagents and samples were added according to the 5α-reductase reaction system shown in Table 1. Samples and finasteride samples of each dilution were added 4 times. After incubation at 37℃ for 60min, the decrease in absorbance at 340nm was measured.

[0081] Inhibition rate (%) = (blank ⊿A-sample ⊿A) / (blank ⊿A)×100

[0082] Table 1 5α-reductase reaction system reagent dosage (μL)

[0083]

[0084] Experimental results:

[0085] Inhibition rates and IC values ​​of finasteride at different concentration gradients, samples of Example 1 at different concentration gradients, and samples of Comparative Examples 1 to 2 on 5α-reductase 50 The results are shown in Table 2. Figure 1-2 .

[0086] Table 2 5α-reductase inhibition rate and IC 50

[0087]

[0088] According to the experimental results, it can be found that the red pine lactone sample has basically no obvious 5α-reductase inhibitory ability, the aconitum biflavonoids have moderate 5α-reductase inhibitory ability, and Example 1 has good 5α-reductase inhibitory ability at a concentration of 2.24-35 mg / mL.

[0089] Experimental Example 2

[0090] Human efficacy testing

[0091] 1. Subject recruitment

[0092] 30 subjects were recruited.

[0093] Inclusion criteria:

[0094] ① Those with oily or mixed skin (Dr. Baumann's skin classification score is between 27 and 44), who do not apply any product after washing their face the night before, do not wash their face the next morning, sit quietly for 30 minutes in a constant temperature and humidity environment, and whose forehead oil test average value reaches 100;

[0095] ②Facial lactic acid test is positive;

[0096] ③No products related to the tested efficacy have been used in the past month;

[0097] ④ Those without severe systemic diseases, immunodeficiency or autoimmune diseases;

[0098] ⑤ Those without active allergic diseases;

[0099] ⑥ Those who have no history of allergy to skin care cosmetics;

[0100] ⑦ Those who have not used hormone drugs and immunosuppressants recently;

[0101] ⑧ Those who have not participated in other human experiments or clinical trials;

[0102] ⑨ Those who are willing to participate and can complete the required content according to the test requirements;

[0103] ⑩Age: 18-45 years old; gender is not limited.

[0104] Exclusion criteria:

[0105] ① Those who do not meet the criteria for oily skin or those with severe acne;

[0106] ② Those who have participated in the test on oil control and its effect on skin condition within the last month;

[0107] ③People with skin allergic diseases;

[0108] ④ Those who are easily allergic to cosmetics;

[0109] ⑤ Those who have recently used hormone drugs and immunosuppressants;

[0110] ⑥Those with low degree of cooperation.

[0111] 2. Sample distribution

[0112] Sample names: Sample A (Example 1), Sample B (Example 2), Sample C (Example 3);

[0113] Distribution: Volunteers were randomly divided into 3 groups, 10 in each group, and sample A, sample B, and sample C were used on the whole face respectively;

[0114] Long-term effect: forehead on both sides (the area from above the eyebrow to the hairline, select 3 points at a distance of 1cm, 3cm, 5cm, and 7cm from the midline, respectively).

[0115] How to use: Use on the entire face, once in the morning and once in the evening. After cleansing every day, use only this sample, 6 to 8 drops each time or adjust the number of drops according to your own situation, apply evenly on the face and wait for it to be absorbed.

[0116] 3. Index detection

[0117] On the 0th, 7th, 14th, 21st and 28th day after the volunteers used the samples, indicators such as oil on the forehead and cheeks (observing the amount of oil produced), skin imaging, and transepidermal water loss (TEWL) were tested. The testing order and time were kept basically consistent to reduce errors.

[0118] The changes in oil secretion and transepidermal water loss in each group are shown in Table 3 and Table 4, respectively. Figure 3 and Figure 4 .

[0119] Table 3 Changes in oil secretion in each group

[0120] Group Day 0 Day 7 Day 14 Day 21 Day 28 A sample 179.14±22.03 168.59±25.35* 157.27±29.54*# 146.21±26.47*# 140.23±15.75*# Sample B 175.67±25.36 173.33±19.58 168.67±23.45 163.33±30.06 158.33±22.74 C sample 179.78±21.13 176.37±15.08* 174.32±22.72*# 173.61±18.31*# 173.28±21.03*#

[0121] Note: *: compared with the same group, P < 0.05; #: compared with the other groups, P < 0.05.

[0122] Table 4 Changes of transepidermal water loss in each group

[0123] Group Day 0 Day 7 Day 14 Day 21 Day 28 A sample 25.96±4.03 21.28±4.25 17.04±3.28*# 14.48±5.02*# 13.48±4.01*# Sample B 25.43±7.65 24.34±6.33 23.21±6.35# 19.09±5.11# 17.14±7.67*# C sample 26.27±4.03 25.85±5.51 23.91±2.82*# 24.32±7.13*# 25.23±6.14*#

[0124] Note: *: compared with the same group, P < 0.05; #: compared with the other groups, P < 0.05.

[0125] According to the results, after using the samples for 28 days, sample A showed a good ability to harmonize water and oil, with the secretion of oil reduced by 22% and the water loss reduced by 48%. Sample B has a certain ability to harmonize water and oil, with the secretion of oil reduced by 10% and the water loss reduced by 32%. There was no significant change in the oil and water loss of sample C after use, with the secretion of oil reduced by 4% and the water loss reduced by 4%. In summary, when the amount of red pine lactone in the formula is relatively large, there is basically no obvious ability to harmonize water and oil; when the amount of tassel-flowered cypress flavonoids in the formula is too much, it has a certain ability to harmonize water and oil; and when red pine lactone and tassel-flowered cypress flavonoids are mixed in a certain ratio, the effect of water and oil harmonization is significantly improved, and the effect is significant due to the above two situations. Therefore, it is believed that a certain amount of red pine lactone can promote the effect of tassel-flowered cypress flavonoids on the water and oil harmonization of the skin.

[0126] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A composition having water-oil coordinating effect, characterized in that: The invention comprises 0.5 to 3 parts of red pine lactone and 1 to 10 parts of aconitum biflavonoids by weight.

2. The composition having water-oil coordinating effect according to claim 1, characterized in that: The invention comprises 0.5-2 parts of koreanolide and 3-7 parts of aconitum biflavonoids by weight.

3. The composition having water-oil coordinating effect according to claim 1, characterized in that: The invention comprises 0.8-1.2 parts of koreanolide and 4-6 parts of aconitum biflavonoids by weight.

4. The composition having water-oil coordinating effect according to claim 3, characterized in that: The invention comprises 1 part of red pine lactone and 5 parts of aconitum biflavonoids by weight.

5. The composition having water-oil coordinating effect according to claim 1, characterized in that: The composition having the effect of water-oil coordination also includes a solvent.

6. The composition having water-oil coordinating effect according to claim 5, characterized in that: The solvent includes any one or more of butanediol, hexanediol, propylene glycol, glycerol and n-butanol.

7. The composition having water-oil coordinating effect according to claim 1, characterized in that: In the composition with water-oil coordinating effect, the total mass concentration of the red pine lactone and the aconitum biflavonoids is 0.3% to 50%.

8. The composition having water-oil coordinating effect according to claim 1, characterized in that: The composition having the effect of water-oil coordination includes any one of a liquid preparation and an ointment.

9. The composition having water-oil coordinating effect according to claim 1, characterized in that: Also included are functional additives; the functional additives include at least one of an emulsifier, a softener and a conditioner.

10. The composition having water-oil coordinating effect according to claim 1, characterized in that: It includes the following components by mass: 0.5 to 3 parts of red pine lactone, 1 to 10 parts of aconitum biflavonoids, 5 to 15 parts of alcohol solvents and 0.01 to 3 parts of functional additives.

11. Use of the composition with water-oil blending effect according to any one of claims 1 to 10 in the preparation of cosmetics.

12. The use according to claim 11, characterized in that: The cosmetics include any one or more of cleansing milk, lotion, cream, ointment and hair care products.

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