A high-voltage high-frequency signal generation circuit for mass spectrometry separation and its operation method

Abstract

A high-voltage high-frequency signal generation circuit for mass spectrometry separation and its operation method, comprising: a square-wave signal generation circuit, a driving circuit, a coupling circuit, a power amplification circuit and a boosting circuit; the square-wave signal output terminal of the square-wave signal generation circuit is connected to the square-wave signal input terminal of the driving circuit, the high-drive square-wave signal output terminal of the driving circuit is connected to the high-drive square-wave signal input terminal of the coupling circuit, the sine alternating signal output terminal of the coupling circuit is connected to the alternating signal input terminal of the power amplification circuit, the high-power sine alternating signal output terminal of the power amplification circuit is connected to the high-power alternating signal input terminal of the boosting circuit, and the kilovolt sine alternating signal output terminal of the boosting circuit is connected to the poles of the linear trap. This design can not only realize the output of high-amplitude radio frequency periodic oscillation signals through the cooperation of digital and analog modules, but also effectively improve the efficiency of the output alternating signal on the premise of avoiding the influence of signal crossover distortion.

Description

Technical Field

[0001] The present invention relates to a signal generating circuit, and particularly to a high-voltage high-frequency signal generating circuit for mass spectrometry separation and its operation method, which is specifically applicable to a high-voltage high-frequency signal generating circuit for mass spectrometry separation that is small in volume and large in amplitude of the output alternating signal and its operation method. Background Art

[0002] The trapping and separation of specific microparticles have extensive applications in the fields of physics, chemistry, and biology, and quantum computing is one of its application scenarios. Traditional computers are composed of semiconductors as computing units and can only present data in two states, which greatly limits the form and efficiency of data processing. In recent years, the emerging quantum computers utilize the microscopic state of quantum to achieve the recording and processing of multiple data states, providing the possibility for parallel computing.

[0003] J.I. Cirac and P. Zoller first proposed in 1995 to use mass spectrometry separation technology for quantum computing research, that is, to capture different forms of specific quantum to achieve data expression. In a quantum computer, a quantum can not only be in various orthogonal states but also in an entangled state, and can simultaneously process multiple different situations during the operation. Therefore, quantum computing can be applied to large-scale complex parallel computing systems, and this advantage cannot be surpassed by classical computers. In a specific spatial environment, it is required that quantum exists in the form of charged ions, and these charged ions are easily involved in chemical reactions and recombination with other charged ions. Therefore, it is very necessary to use electromagnetic field technology to overcome the interaction between charged microparticles and make them stably exist in a specific space. A particle mass filter is a quadrupole linear trap device based on an alternating electric field, which can make target particles exist stably in an ultra-high vacuum environment without being interfered by the outside world. The particle mass analyzer linear trap combines an electrostatic field and a radio frequency field to make charged particles be confined at the mechanical equilibrium point and move back and forth like a simple harmonic oscillator, so that charged microparticles stably exist in a specific space. The alternating field of the particle mass filter is mainly provided by a radio frequency source. Therefore, the amplitude and stability of the radio frequency signal output by the radio frequency source are closely related to the trapping of particles, and its volume and power consumption are also key issues of concern for the miniaturization of the quantum computing system.

[0004] Traditional radio frequency sources for high-voltage high-frequency signals in mass spectrometry separation usually use commercial signal generators to output small radio frequency signals, and then boost the voltage through a step-up coil. Existing commercial signal generators are large in volume and high in operating power, which is not conducive to miniaturization. At the same time, due to the small output signal power of the signal generator and the limited voltage boosting ability of the coil, the amplitude of the output alternating signal is only a few hundred volts, making the effect of the alternating field in confining particles not ideal enough.

[0005] The invention patent application with the application number 201310596375.4 and the application date of March 23, 2010 discloses a switchable radio frequency power source system. This system includes an oscillator that provides a frequency signal, a radio frequency power source component that receives the frequency signal and outputs a radio frequency signal at a first frequency or a second frequency, and a switching mechanism that receives the output of the radio frequency power source component and selectively applies the radio frequency signal with the first frequency to the first narrowband amplifier or applies the radio frequency signal with the second frequency to the second narrowband amplifier. Although this design can achieve switching between radio frequency powers at multiple frequencies, this design still has the following defects:

[0006] The system has a relatively large volume and the amplitude of the output alternating signal is small.

[0007] Disclosing the information of this background art section is only intended to increase the understanding of the overall background of the present application, and should not be regarded as an admission or any form of implication that this information constitutes the prior art already known to those of ordinary skill in the art. Summary of the Invention

[0008] The object of the present invention is to overcome the disadvantages of the relatively large volume of the existing system and the small amplitude of the output alternating signal, and provides a mass spectrometry separation high-voltage high-frequency signal generating circuit with a relatively small volume and a large amplitude of the output alternating signal and its operation method.

[0009] To achieve the above object, the technical solution of the present invention is:

[0010] A mass spectrometry separation high-voltage high-frequency signal generating circuit and its operation method. The signal generating circuit includes: a square wave signal generating circuit, a driving circuit, a coupling circuit, a power amplification circuit, and a boosting circuit.

[0011] The square wave signal output terminal of the square wave signal generating circuit is connected to the square wave signal input terminal of the driving circuit. The driving circuit is a MOS transistor driver. The high driving square wave signal output terminal of the driving circuit is connected to the high driving square wave signal input terminal of the coupling circuit. The sine alternating signal output terminal of the coupling circuit is connected to the alternating signal input terminal of the power amplification circuit. The high-power sine alternating signal output terminal of the power amplification circuit is connected to the high-power alternating signal input terminal of the boosting circuit. The kilovolt sine alternating signal output terminal of the boosting circuit is connected to the pole of the linear trap.

[0012] The square wave signal generating circuit includes a first resistor R1, a second resistor R2, a first capacitor C1, a first NOT gate circuit U3A and a second NOT gate circuit U3B. The second resistor R2 is a variable resistor. The second resistor R2 is connected in series with the first resistor R1 and the first capacitor C1 in sequence and then grounded. The first resistor R1, the second resistor R2 and the first capacitor C1 together form a Schmitt trigger. The first resistor R1 and the second resistor R2 are connected in series and then in parallel with the first NOT gate circuit U3A. The input port of the first NOT gate circuit U3A is connected between the first resistor R1 and the first capacitor C1. The output port of the first NOT gate circuit U3A is connected to the input port of the second NOT gate circuit U3B. The output port of the second NOT gate circuit U3B is the square wave signal output end of the square wave signal generating circuit.

[0013] The coupling circuit includes a coupling coil T1, a ninth resistor R9, a twelfth resistor R12, a sixth capacitor C6, a seventh capacitor C7 and a fourteenth capacitor C14. One end of the sixth capacitor C6 is connected to the high drive square wave signal output end of the drive circuit. The sixth capacitor C6 is connected in series with the primary coil of the coupling coil T1 and the twelfth resistor R12 and then grounded. One end of the secondary coil of the coupling coil T1 is connected in series with the seventh capacitor C7 and is the first sine alternating signal output end of the coupling circuit. The first sine alternating signal output end of the coupling circuit is connected to the first sine alternating signal input end of the power amplifier circuit. The other end of the secondary coil of the coupling coil T1 is connected in series with the fourteenth capacitor C14 and is the second sine alternating signal output end of the coupling circuit. The second sine alternating signal output end of the coupling circuit is connected to the second sine alternating signal input end of the power amplifier circuit. The middle of the secondary coil of the coupling coil T1 is connected in series with the ninth resistor R9 and then grounded. The phase difference between the two sine AC signals output by the secondary coil of the coupling coil T1 is 180°.

[0014] The power amplification circuit includes a fourth resistor R4, a fifth resistor R5, a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a tenth resistor R10, an eleventh resistor R11, a thirteenth resistor R13, a fourteenth resistor R14, a fifteenth resistor R15, a tenth capacitor C10, an eleventh capacitor C11, a twelfth capacitor C12, a thirteenth capacitor C13, a first triode Q1 and a second triode Q2. One end of the fourth resistor R4 is the first sine alternating signal input terminal of the power amplification circuit. The other end of the fourth resistor R4 is grounded after being serially connected with the fifth resistor R5. The clamping power supply is serially connected with the sixth resistor R6 and the fifth resistor R5 in sequence and then grounded. One end of the thirteenth resistor R13 is the second sine alternating signal input terminal of the power amplification circuit. The other end of the thirteenth resistor R13 is grounded after being serially connected with the fourteenth resistor R14. The clamping power supply is serially connected with the eleventh resistor R11 and the fourteenth resistor R14 in sequence and then grounded. The tenth capacitor C10 and the eleventh capacitor C11 are connected in parallel. One end of the tenth capacitor C10 and the eleventh capacitor C11 are both connected to the clamping power supply. The other end of the tenth capacitor C10 and the eleventh capacitor C11 are both grounded;

[0015] The source S of the first triode Q1 is grounded after being serially connected with the eighth resistor R8. The gate G of the first triode Q1 is grounded after being serially connected with the fifth resistor R5. The drain D of the first triode Q1 is grounded after being serially connected with the seventh resistor R7, the twelfth capacitor C12 and the fifth resistor R5 in sequence. The drain D of the first triode Q1 is the first high-power sine alternating signal output terminal of the power amplification circuit. The first high-power sine alternating signal output terminal of the power amplification circuit is connected to the first high-power sine alternating signal input terminal of the boost circuit;

[0016] The source S of the second triode Q2 is grounded after being serially connected with the fifteenth resistor R15. The gate G of the second triode Q2 is serially connected between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is serially connected with the tenth resistor R10 and the thirteenth capacitor C13 in sequence and then serially connected between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is the second high-power sine alternating signal output terminal of the power amplification circuit. The second high-power sine alternating signal output terminal of the power amplification circuit is connected to the second high-power sine alternating signal input terminal of the boost circuit.

[0017] The boost circuit includes a second boost coil T2, an eighth capacitor C8, a fifteenth capacitor C15 and an inductor coil L1. One end of the primary coil of the second boost coil T2 is the first high-power sine alternating signal input terminal of the boost circuit. The other end of the primary coil of the second boost coil T2 is the second high-power sine alternating signal input terminal of the boost circuit,

[0018] The middle of the primary coil of the second boost coil T2 is connected to the 24V power supply in series with an inductance coil L1 and a filter circuit in sequence. One end of the secondary coil of the second boost coil T2 is connected to the first kilovolt sine alternating signal output terminal of the signal generation circuit after being connected in series with a fifteenth capacitor C15. The other end of the secondary coil of the second boost coil T2 is connected to one end of a ninth capacitor C9 after being connected in series with an eighth capacitor C8 in sequence. The other end of the ninth capacitor C9 is the second kilovolt sine alternating signal output terminal of the signal generation circuit.

[0019] The filter circuit includes a sixteenth capacitor C16, a seventeenth capacitor C17, and an eighteenth capacitor C18. The sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 are all connected in parallel with each other. One end of the sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 is connected in series between the 24V power supply and the inductance coil L1. The other ends of the sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 are all grounded.

[0020] The boost multiple of the second boost coil T2 is fifty times.

[0021] An operating method for a mass spectrometry separation high-voltage high-frequency signal generation circuit, the operating method includes:

[0022] The first step: Output a square wave signal. Turn on the main power supply. The main power supply supplies power to each electrical component in the signal generation circuit 1. The input level of the Schmitt trigger is zero. At this time, the Schmitt trigger outputs a high-level signal. The high-level signal returns to the input terminal after passing through a first resistor R1 and a second resistor R2, and charges the first capacitor C1. When the first capacitor C1 reaches the first threshold, the output of the Schmitt trigger flips. At this time, the Schmitt trigger outputs a low-level signal, and the first capacitor C1 starts to discharge, causing the input level of the Schmitt trigger to gradually decrease. When the input voltage of the Schmitt trigger is lower than the second threshold, the output of the Schmitt trigger flips again. At this time, a cycle of the square wave signal is completed. Repeat the cycle of the square wave signal and output the square wave signal to the driver. At this time, the step of outputting the square wave signal is completed;

[0023] The second step: Improve the signal driving ability. After the driver receives the square wave signal output by the signal generation circuit, it amplifies the current of the square wave signal to improve the signal driving ability, and outputs the high-driving square wave signal with improved signal driving ability to the coupling circuit. At this time, the step of improving the signal driving ability is completed;

[0024] Step 3: Convert digital signal to analog signal. After the primary coil in the coupling coil T1 receives the square wave signal sent by the driver, the square wave signal is converted into a sinusoidal alternating signal through the coupling coil T1, and the converted sinusoidal alternating signal is equally divided into two signals with equal power through both ends of the secondary coil in the coupling coil T1 and output to the first sinusoidal alternating signal input terminal and the second sinusoidal alternating signal input terminal of the power amplification circuit. At this time, the step of converting digital signal to analog signal is completed;

[0025] Step 4: Amplify the power of the alternating signal. The sinusoidal alternating signal received by the first sinusoidal alternating signal input terminal in the power amplification circuit enters the first triode Q1 after passing through the fourth resistor R4. At the same time, the sinusoidal alternating signal received by the second sinusoidal alternating signal input terminal in the power amplification circuit enters the second triode Q2. When the first triode Q1 and the second triode Q2 receive a negative voltage signal, the corresponding triode is cut off. When the first triode Q1 and the second triode Q2 receive a positive voltage signal, the corresponding triode conducts, amplifying the alternating signal passing through the triode, and outputting it to the boost circuit through the first high-power sinusoidal alternating signal output terminal and the second high-power sinusoidal alternating signal output terminal. At this time, the step of amplifying the power of the alternating signal is completed;

[0026] Step 5: Boost the alternating signal. The boost circuit boosts the high-power sinusoidal alternating signal through the second boost coil T2 and outputs the boosted alternating signal to the poles of the linear trap. At this time, the step of boosting the signal is completed.

[0027] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0028] 1. In the high-voltage high-frequency signal generation circuit for mass spectrometry separation of the present invention, the square wave signal generator and the driver are digital modules, and the power amplification circuit and the boost circuit are analog modules. The digital module and the analog module are connected through a coupler. The square wave signal generator can output an original periodic oscillation signal, that is, a square wave signal, and improve the driving ability of the square wave signal through the driver. The square wave signal is converted into an analog signal through the coupler. At the same time, the coupler evenly distributes the analog signal into two outputs. The two analog signals have high symmetry. The two analog signals are amplified in power and boosted through the power amplification circuit and the boost circuit and then output to the poles of the linear trap. Therefore, this design can cooperate with the digital module and the analog module to achieve the output of a radio frequency periodic oscillation signal with high amplitude and stability, and effectively reduce the volume and power consumption of the system.

[0029] 2. In a high-voltage high-frequency signal generation circuit for mass spectrometry separation and its operation method of the present invention, a square-wave signal generator forms a Schmitt trigger through a first resistor, a second resistor, and a first capacitor. The Schmitt trigger and a first NOT gate circuit form a multivibrator. The multivibrator can cause the output to flip through the charging and discharging of the first capacitor to form a square-wave signal. At the same time, the Schmitt trigger also has the function of shaping and reducing noise of the square-wave signal. Therefore, this design can generate a square-wave signal through the cooperation of the Schmitt trigger and the first NOT gate circuit, and shape and reduce noise of the square-wave signal, effectively improving the signal-to-noise ratio and stability of the square-wave signal.

[0030] 3. In a high-voltage high-frequency signal generation circuit for mass spectrometry separation and its operation method of the present invention, the drive circuit is a MOS transistor driver, which can improve the signal drive ability to match the subsequent analog module. Therefore, this design can improve the signal drive ability through the MOS transistor driver to match the subsequent analog module.

[0031] 4. In a high-voltage high-frequency signal generation circuit for mass spectrometry separation and its operation method of the present invention, the power amplification circuit is a class AB push-pull power amplifier, which can amplify the power of the signal, making the output alternating signal more efficient and avoiding the influence of signal crossover distortion. Therefore, this design can amplify the power of the signal through the power amplification circuit, effectively improving the efficiency of the output alternating signal on the premise of avoiding the influence of signal crossover distortion.

[0032] 5. In a high-voltage high-frequency signal generation circuit for mass spectrometry separation and its operation method of the present invention, the second resistor in the square-wave signal generator is an adjustable resistor. By adjusting the resistor R in the second resistor, the frequency of the square-wave signal output by the square-wave signal generator can be made consistent with the resonance frequency of the second boost coil in the boost circuit, so that the voltage amplitude of the alternating signal output by the power amplification circuit can be further boosted to more than a thousand volts through the second boost coil. Therefore, this design can make the square-wave signal frequency consistent with the resonance frequency of the second boost coil by adjusting the adjustable resistor in the square-wave signal generator, effectively increasing the amplitude of the alternating signal output by the system. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 is the circuit schematic diagram of the present invention.

[0034] Figure 2 is the signal change diagram of the present invention.

[0035] In the figure: square-wave signal generation circuit 1, drive circuit 2, coupling circuit 3, power amplification circuit 4, boost circuit 5, pole 6, filter circuit 7. DETAILED DESCRIPTION OF THE INVENTION

[0036] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0037] See Figures 1 to 2 , a high-voltage high-frequency signal generating circuit for mass spectrometry separation. The signal generating circuit includes: a square-wave signal generating circuit 1, a driving circuit 2, a coupling circuit 3, a power amplification circuit 4, and a boosting circuit 5.

[0038] The square-wave signal output terminal of the square-wave signal generating circuit 1 is connected to the square-wave signal input terminal of the driving circuit 2. The driving circuit 2 is a MOS transistor driver. The high-drive square-wave signal output terminal of the driving circuit 2 is connected to the high-drive square-wave signal input terminal of the coupling circuit 3. The sine alternating signal output terminal of the coupling circuit 3 is connected to the alternating signal input terminal of the power amplification circuit 4. The high-power sine alternating signal output terminal of the power amplification circuit 4 is connected to the high-power alternating signal input terminal of the boosting circuit 5. The kilovolt sine alternating signal output terminal of the boosting circuit 5 is connected to the pole 6 of the linear trap.

[0039] The square-wave signal generating circuit 1 includes a first resistor R1, a second resistor R2, a first capacitor C1, a first NOT gate circuit U3A, and a second NOT gate circuit U3B. The second resistor R2 is an adjustable resistor. The second resistor R2 is sequentially connected in series with the first resistor R1 and the first capacitor C1 and then grounded. The first resistor R1, the second resistor R2, and the first capacitor C1 together form a Schmitt trigger. The series connection of the first resistor R1 and the second resistor R2 is connected in parallel with the first NOT gate circuit U3A. The input port of the first NOT gate circuit U3A is connected between the first resistor R1 and the first capacitor C1. The output port of the first NOT gate circuit U3A is connected to the input port of the second NOT gate circuit U3B. The output port of the second NOT gate circuit U3B is the square-wave signal output terminal of the square-wave signal generating circuit 1.

[0040] The coupling circuit 3 includes a coupling coil T1, a ninth resistor R9, a twelfth resistor R12, a sixth capacitor C6, a seventh capacitor C7, and a fourteenth capacitor C14. One end of the sixth capacitor C6 is connected to the high-drive square-wave signal output terminal of the drive circuit 2. The sixth capacitor C6 is connected to the ground after being connected in series with the primary coil of the coupling coil T1 and the twelfth resistor R12. One end of the secondary coil of the coupling coil T1 is connected in series with the seventh capacitor C7 to be the first sinusoidal alternating signal output terminal of the coupling circuit 3. The first sinusoidal alternating signal output terminal of the coupling circuit 3 is connected to the first sinusoidal alternating signal input terminal of the power amplification circuit 4. The other end of the secondary coil of the coupling coil T1 is connected in series with the fourteenth capacitor C14 to be the second sinusoidal alternating signal output terminal of the coupling circuit 3. The second sinusoidal alternating signal output terminal of the coupling circuit 3 is connected to the second sinusoidal alternating signal input terminal of the power amplification circuit 4. The middle of the secondary coil of the coupling coil T1 is connected in series with the ninth resistor R9 and then grounded. The phase difference between the two sinusoidal AC signals output by the secondary coil of the coupling coil T1 is 180°.

[0041] The power amplification circuit 4 includes a fourth resistor R4, a fifth resistor R5, a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a tenth resistor R10, an eleventh resistor R11, a thirteenth resistor R13, a fourteenth resistor R14, a fifteenth resistor R15, a tenth capacitor C10, an eleventh capacitor C11, a twelfth capacitor C12, a thirteenth capacitor C13, a first triode Q1, and a second triode Q2. One end of the fourth resistor R4 is the first sinusoidal alternating signal input terminal of the power amplification circuit 4. The other end of the fourth resistor R4 is connected to the ground after being connected in series with the fifth resistor R5. The clamping power supply is connected to the ground after being connected in series with the sixth resistor R6 and the fifth resistor R5 in sequence. One end of the thirteenth resistor R13 is the second sinusoidal alternating signal input terminal of the power amplification circuit 4. The other end of the thirteenth resistor R13 is connected to the ground after being connected in series with the fourteenth resistor R14. The clamping power supply is connected to the ground after being connected in series with the eleventh resistor R11 and the fourteenth resistor R14 in sequence. The tenth capacitor C10 and the eleventh capacitor C11 are connected in parallel. One end of the tenth capacitor C10 and the eleventh capacitor C11 are both connected to the clamping power supply. The other ends of the tenth capacitor C10 and the eleventh capacitor C11 are both grounded;

[0042] The source S of the first triode Q1 is connected to the ground after being connected in series with the eighth resistor R8. The gate G of the first triode Q1 is connected to the ground after being connected in series with the fifth resistor R5. The drain D of the first triode Q1 is connected to the ground after being connected in series with the seventh resistor R7, the twelfth capacitor C12, and the fifth resistor R5 in sequence. The drain D of the first triode Q1 is the first high-power sinusoidal alternating signal output terminal of the power amplification circuit 4. The first high-power sinusoidal alternating signal output terminal of the power amplification circuit 4 is connected to the first high-power sinusoidal alternating signal input terminal of the boost circuit 5;

[0043] The source S of the second triode Q2 is grounded after being serially connected with a fifteenth resistor R15. The gate G of the second triode Q2 is connected in series between an eleventh resistor R11 and a fourteenth resistor R14. The drain D of the second triode Q2 is serially connected with a tenth resistor R10 and a thirteenth capacitor C13 in sequence and then connected in series between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is the second high-power sinusoidal alternating signal output terminal of the power amplification circuit 4, and the second high-power sinusoidal alternating signal output terminal of the power amplification circuit 4 is connected to the second high-power sinusoidal alternating signal input terminal of the boost circuit 5.

[0044] The boost circuit 5 includes a second boost coil T2, an eighth capacitor C8, a fifteenth capacitor C15, and an inductor coil L1. One end of the primary coil of the second boost coil T2 is the first high-power sinusoidal alternating signal input terminal of the boost circuit 5, and the other end of the primary coil of the second boost coil T2 is the second high-power sinusoidal alternating signal input terminal of the boost circuit 5.

[0045] The middle of the primary coil of the second boost coil T2 is serially connected with the inductor coil L1 and the filter circuit 7 in sequence and then connected to the 24V power supply. One end of the secondary coil of the second boost coil T2 is serially connected with the fifteenth capacitor C15 and is the first kilovolt sinusoidal alternating signal output terminal of the signal generation circuit. The other end of the secondary coil of the second boost coil T2 is serially connected with the eighth capacitor C8 in sequence and then connected to one end of a ninth capacitor C9. The other end of the ninth capacitor C9 is the second kilovolt sinusoidal alternating signal output terminal of the signal generation circuit.

[0046] The filter circuit 7 includes a sixteenth capacitor C16, a seventeenth capacitor C17, and an eighteenth capacitor C18. The sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 are all connected in parallel with each other. One end of the sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 is serially connected between the 24V power supply and the inductor coil L1, and the other ends of the sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 are all grounded.

[0047] The boost multiple of the second boost coil T2 is fifty times.

[0048] An operating method for a mass spectrometry separation high-voltage high-frequency signal generation circuit, the operating method includes:

[0049] Step 1: Output a square wave signal and turn on the main power supply. The main power supply powers each electrical component in the signal generation circuit 1. The input level of the Schmitt trigger is zero. At this time, the Schmitt trigger outputs a high-level signal. The high-level signal returns to the input terminal after passing through the first resistor R1 and the second resistor R2, charging the first capacitor C1. When the first capacitor C1 reaches the first threshold, the output of the Schmitt trigger flips. At this time, the Schmitt trigger outputs a low-level signal, and the first capacitor C1 starts to discharge, causing the input level of the Schmitt trigger to gradually decrease. When the input voltage of the Schmitt trigger is lower than the second threshold, the output of the Schmitt trigger flips again. At this time, one cycle of the square wave signal is completed. Repeat the square wave signal cycle and output the square wave signal to the driver 2. At this time, the step of outputting the square wave signal is completed;

[0050] Step 2: Improve the signal driving ability. After receiving the square wave signal output by the signal generation circuit, the driver 2 amplifies the current of the square wave signal to improve the signal driving ability, and outputs the high-drive square wave signal with improved signal driving ability to the coupling circuit 3. At this time, the step of improving the signal driving ability is completed;

[0051] Step 3: Convert digital signal to analog signal. After the primary coil in the coupling coil T1 receives the square wave signal sent by the driver 2, the square wave signal is converted into a sinusoidal alternating signal through the coupling coil T1, and the converted sinusoidal alternating signal is equally divided into two signals with equal power and output to the first sinusoidal alternating signal input terminal and the second sinusoidal alternating signal input terminal of the power amplifier circuit 4 through both ends of the secondary coil in the coupling coil T1. At this time, the step of converting digital signal to analog signal is completed;

[0052] Step 4: Amplify the power of the alternating signal. The sinusoidal alternating signal received by the first sinusoidal alternating signal input terminal in the power amplifier circuit 4 enters the first triode Q1 after passing through the fourth resistor R4. At the same time, the sinusoidal alternating signal received by the second sinusoidal alternating signal input terminal in the power amplifier circuit 4 enters the second triode Q2. When the first triode Q1 and the second triode Q2 receive a negative voltage signal, the corresponding triode is cut off. When the first triode Q1 and the second triode Q2 receive a positive voltage signal, the corresponding triode conducts, amplifying the alternating signal passing through the triode, and outputting it to the boost circuit 5 through the first high-power sinusoidal alternating signal output terminal and the second high-power sinusoidal alternating signal output terminal. At this time, the step of amplifying the power of the alternating signal is completed;

[0053] Step 5: Boost the alternating signal. The boost circuit 5 boosts the high-power sinusoidal alternating signal through the second boost coil T2 and outputs the boosted alternating signal to the pole 6 of the linear trap. At this time, the step of boosting the signal is completed.

[0054] The principle of the present invention is described as follows:

[0055] In this design, the high-voltage high-frequency alternating electric field signal specifically refers to an alternating electric field signal with a voltage between 0 - 2000V and a frequency between 0.5 - 10MHz.

[0056] In this design.

[0057] Embodiment 1:

[0058] A mass spectrometry separation high-voltage high-frequency signal generation circuit, the signal generation circuit includes: a square wave signal generation circuit 1, a drive circuit 2, a coupling circuit 3, a power amplification circuit 4, and a boost circuit 5.

[0059] The square wave signal output terminal of the square wave signal generation circuit 1 is connected to the square wave signal input terminal of the drive circuit 2. The drive circuit 2 is a MOS transistor driver. The high drive square wave signal output terminal of the drive circuit 2 is connected to the high drive square wave signal input terminal of the coupling circuit 3. The sine alternating signal output terminal of the coupling circuit 3 is connected to the alternating signal input terminal of the power amplification circuit 4. The high-power sine alternating signal output terminal of the power amplification circuit 4 is connected to the high-power alternating signal input terminal of the boost circuit 5. The kilovolt sine alternating signal output terminal of the boost circuit 5 is connected to the pole 6 of the linear trap.

[0060] The square wave signal generation circuit 1 includes a first resistor R1, a second resistor R2, a first capacitor C1, a first NOT gate circuit U3A, and a second NOT gate circuit U3B. The second resistor R2 is an adjustable resistor. The second resistor R2 is sequentially connected in series with the first resistor R1 and the first capacitor C1 and then grounded. The first resistor R1, the second resistor R2, and the first capacitor C1 together form a Schmitt trigger. The series connection of the first resistor R1 and the second resistor R2 is connected in parallel with the first NOT gate circuit U3A. The input port of the first NOT gate circuit U3A is connected between the first resistor R1 and the first capacitor C1. The output port of the first NOT gate circuit U3A is connected to the input port of the second NOT gate circuit U3B. The output port of the second NOT gate circuit U3B is the square wave signal output terminal of the square wave signal generation circuit 1.

[0061] The coupling circuit 3 includes a coupling coil T1, a ninth resistor R9, a twelfth resistor R12, a sixth capacitor C6, a seventh capacitor C7, and a fourteenth capacitor C14. One end of the sixth capacitor C6 is connected to the high-drive square-wave signal output end of the drive circuit 2. The sixth capacitor C6 is connected to the ground after being connected in series with the primary coil of the coupling coil T1 and the twelfth resistor R12. One end of the secondary coil of the coupling coil T1 is connected in series with the seventh capacitor C7 to be the first sine alternating signal output end of the coupling circuit 3. The first sine alternating signal output end of the coupling circuit 3 is connected to the first sine alternating signal input end of the power amplifier circuit 4. The other end of the secondary coil of the coupling coil T1 is connected in series with the fourteenth capacitor C14 to be the second sine alternating signal output end of the coupling circuit 3. The second sine alternating signal output end of the coupling circuit 3 is connected to the second sine alternating signal input end of the power amplifier circuit 4. The middle of the secondary coil of the coupling coil T1 is connected in series with the ninth resistor R9 and then grounded. The phase difference between the two sine AC signals output by the secondary coil of the coupling coil T1 is 180°.

[0062] The power amplifier circuit 4 includes a fourth resistor R4, a fifth resistor R5, a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a tenth resistor R10, an eleventh resistor R11, a thirteenth resistor R13, a fourteenth resistor R14, a fifteenth resistor R15, a tenth capacitor C10, an eleventh capacitor C11, a twelfth capacitor C12, a thirteenth capacitor C13, a first triode Q1, and a second triode Q2. One end of the fourth resistor R4 is the first sine alternating signal input end of the power amplifier circuit 4. The other end of the fourth resistor R4 is connected to the ground after being connected in series with the fifth resistor R5. The clamping power supply is connected to the ground after being connected in series with the sixth resistor R6 and the fifth resistor R5 in sequence. One end of the thirteenth resistor R13 is the second sine alternating signal input end of the power amplifier circuit 4. The other end of the thirteenth resistor R13 is connected to the ground after being connected in series with the fourteenth resistor R14. The clamping power supply is connected to the ground after being connected in series with the eleventh resistor R11 and the fourteenth resistor R14 in sequence. The tenth capacitor C10 and the eleventh capacitor C11 are connected in parallel. One end of the tenth capacitor C10 and the eleventh capacitor C11 are both connected to the clamping power supply. The other ends of the tenth capacitor C10 and the eleventh capacitor C11 are both grounded;

[0063] The source S of the first triode Q1 is connected to the ground after being connected in series with the eighth resistor R8. The gate G of the first triode Q1 is connected to the ground after being connected in series with the fifth resistor R5. The drain D of the first triode Q1 is connected to the ground after being connected in series with the seventh resistor R7, the twelfth capacitor C12, and the fifth resistor R5 in sequence. The drain D of the first triode Q1 is the first high-power sine alternating signal output end of the power amplifier circuit 4. The first high-power sine alternating signal output end of the power amplifier circuit 4 is connected to the first high-power sine alternating signal input end of the boost circuit 5;

[0064] The source S of the second triode Q2 is grounded after being connected in series with the fifteenth resistor R15. The gate G of the second triode Q2 is connected in series between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is connected in series with the tenth resistor R10 and the thirteenth capacitor C13 in sequence and then connected in series between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is the second high-power sine alternating signal output terminal of the power amplification circuit 4, and the second high-power sine alternating signal output terminal of the power amplification circuit 4 is connected to the second high-power sine alternating signal input terminal of the boost circuit 5.

[0065] The boost circuit 5 includes a second boost coil T2, an eighth capacitor C8, a fifteenth capacitor C15, and an inductor coil L1. One end of the primary coil of the second boost coil T2 is the first high-power sine alternating signal input terminal of the boost circuit 5, and the other end of the primary coil of the second boost coil T2 is the second high-power sine alternating signal input terminal of the boost circuit 5.

[0066] The middle of the primary coil of the second boost coil T2 is connected to the 24V power supply in series with the inductor coil L1 and the filter circuit 7 in sequence. One end of the secondary coil of the second boost coil T2 is connected in series with the fifteenth capacitor C15 to be the first kilovolt sine alternating signal output terminal of the signal generation circuit. The other end of the secondary coil of the second boost coil T2 is connected to one end of the ninth capacitor C9 in series with the eighth capacitor C8 in sequence. The other end of the ninth capacitor C9 is the second kilovolt sine alternating signal output terminal of the signal generation circuit.

[0067] An operating method for a mass spectrometry separation high-voltage high-frequency signal generation circuit, the operating method includes:

[0068] The first step: Output a square wave signal. Turn on the main power supply. The main power supply supplies power to each electrical component in the signal generation circuit 1. The input level of the Schmidt trigger is zero. At this time, the Schmidt trigger outputs a high-level signal. The high-level signal returns to the input terminal after passing through the first resistor R1 and the second resistor R2, and charges the first capacitor C1. When the first capacitor C1 reaches the first threshold, the output of the Schmidt trigger flips. At this time, the Schmidt trigger outputs a low-level signal, and the first capacitor C1 starts to discharge, causing the input level of the Schmidt trigger to gradually decrease. When the input voltage of the Schmidt trigger is lower than the second threshold, the output of the Schmidt trigger flips again. At this time, a cycle of the square wave signal is completed. Repeat the cycle of the square wave signal and output the square wave signal to the driver 2. The voltage value of the square wave signal output by the signal generation circuit 1 is 5V. At this time, the step of outputting the square wave signal is completed;

[0069] Step 2: Improve the signal driving ability. After receiving the square wave signal output by the signal generation circuit, driver 2 amplifies the current of the square wave signal to improve the signal driving ability, and outputs the high-driving square wave signal with improved signal driving ability to coupling circuit 3. The voltage value of the high-driving square wave signal output by driver 2 is 10V. At this time, the step of improving the signal driving ability is completed;

[0070] Step 3: Convert digital signal to analog signal. After the primary coil in coupling coil T1 receives the square wave signal sent by driver 2, the square wave signal is converted into a sinusoidal alternating signal through coupling coil T1, and the converted sinusoidal alternating signal is equally divided into two signals with equal power and output to the first sinusoidal alternating signal input terminal and the second sinusoidal alternating signal input terminal of power amplification circuit 4 through both ends of the secondary coil in coupling coil T1. The voltage value of the sinusoidal alternating signal output from both ends of the secondary coil in coupling coil T1 is 5V. At this time, the step of converting digital signal to analog signal is completed;

[0071] Step 4: Amplify the power of the alternating signal. The sinusoidal alternating signal received by the first sinusoidal alternating signal input terminal in power amplification circuit 4 enters the first triode Q1 after passing through the fourth resistor R4. At the same time, the sinusoidal alternating signal received by the second sinusoidal alternating signal input terminal in power amplification circuit 4 enters the second triode Q2. When the first triode Q1 and the second triode Q2 receive a negative voltage signal, the corresponding triode is cut off. When the first triode Q1 and the second triode Q2 receive a positive voltage signal, the corresponding triode conducts, amplifying the alternating signal passing through the triode, and outputting it to boost circuit 5 through the first high-power sinusoidal alternating signal output terminal and the second high-power sinusoidal alternating signal output terminal. The voltage value of the high-power sinusoidal alternating signal output by power amplification circuit 4 is 40V. At this time, the step of amplifying the power of the alternating signal is completed;

[0072] Step 5: Boost the alternating signal. Boost circuit 5 boosts the high-power sinusoidal alternating signal with a voltage of 40V received through the second boost coil T2 by 50 times, and outputs the boosted alternating signal to the pole 6 of the linear trap. At this time, the step of boosting the signal is completed.

[0073] Embodiment 2:

[0074] Embodiment 2 is basically the same as Embodiment 1, and the difference lies in:

[0075] The filtering circuit 7 includes a sixteenth capacitor C16, a seventeenth capacitor C17 and an eighteenth capacitor C18. The sixteenth capacitor C16, the seventeenth capacitor C17 and the eighteenth capacitor C18 are all connected in parallel with each other. One ends of the sixteenth capacitor C16, the seventeenth capacitor C17 and the eighteenth capacitor C18 are connected in series between a 24V power supply and an inductor coil L1, and the other ends of the sixteenth capacitor C16, the seventeenth capacitor C17 and the eighteenth capacitor C18 are all grounded.

[0076] Embodiment 3:

[0077] Embodiment 3 is basically the same as Embodiment 2, and the difference lies in that:

[0078] The voltage boosting multiple of the second boosting coil T2 is fifty times.

[0079] The above is only the preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments. Any equivalent modifications or changes made by those of ordinary skill in the art according to the disclosed content of the present invention shall be included in the protection scope recorded in the claims.

Claims

1. A high-voltage high-frequency signal generation circuit for mass spectrometry separation, characterized in that: The signal generation circuit includes: a square wave signal generation circuit (1), a drive circuit (2), a coupling circuit (3), a power amplification circuit (4) and a boost circuit (5). The square wave signal output terminal of the square wave signal generation circuit (1) is connected to the square wave signal input terminal of the drive circuit (2). The drive circuit (2) is a MOS transistor driver. The high drive square wave signal output terminal of the drive circuit (2) is connected to the high drive square wave signal input terminal of the coupling circuit (3). The sine alternating signal output terminal of the coupling circuit (3) is connected to the alternating signal input terminal of the power amplification circuit (4). The high-power sine alternating signal output terminal of the power amplification circuit (4) is connected to the high-power alternating signal input terminal of the boost circuit (5). The kilovolt sine alternating signal output terminal of the boost circuit (5) is connected to the pole (6) of the linear trap. The square wave signal generation circuit (1) includes a first resistor R1, a second resistor R2, a first capacitor C1, a first NOT gate circuit U3A and a second NOT gate circuit U3B. The second resistor R2 is a variable resistor. The second resistor R2 is connected to the ground in series with the first resistor R1 and the first capacitor C1 in sequence. The first resistor R1, the second resistor R2 and the first capacitor C1 together form a Schmitt trigger. The series connection of the first resistor R1 and the second resistor R2 is connected in parallel with the first NOT gate circuit U3A. The input port of the first NOT gate circuit U3A is connected between the first resistor R1 and the first capacitor C1. The output port of the first NOT gate circuit U3A is connected to the input port of the second NOT gate circuit U3B. The output port of the second NOT gate circuit U3B is the square wave signal output terminal of the square wave signal generation circuit (1). The drive circuit (2) is used to improve the signal drive ability to match the subsequent analog module. The coupling circuit (3) is used to convert the square wave signal into a sine alternating signal and output the sine alternating signal to the power amplification circuit (4). The power amplification circuit (4) is a class AB push-pull power amplifier. The power amplification circuit (4) is used to amplify the power of the signal. The boost circuit (5) is used to further boost the voltage amplitude of the alternating signal output by the power amplification circuit to more than kilovolts.

2. A high-voltage high-frequency signal generation circuit for mass spectrometry separation according to claim 1, characterized in that: The coupling circuit (3) includes a coupling coil T1, a ninth resistor R9, a twelfth resistor R12, a sixth capacitor C6, a seventh capacitor C7, and a fourteenth capacitor C14. One end of the sixth capacitor C6 is connected to the high drive square wave signal output end of the drive circuit (2). The sixth capacitor C6 is connected to the ground after being connected in series with the primary coil of the coupling coil T1 and the twelfth resistor R12. One end of the secondary coil of the coupling coil T1 is connected in series with the seventh capacitor C7 to be the first sine alternating signal output end of the coupling circuit (3). The first sine alternating signal output end of the coupling circuit (3) is connected to the first sine alternating signal input end of the power amplification circuit (4). The other end of the secondary coil of the coupling coil T1 is connected in series with the fourteenth capacitor C14 to be the second sine alternating signal output end of the coupling circuit (3). The second sine alternating signal output end of the coupling circuit (3) is connected to the second sine alternating signal input end of the power amplification circuit (4). The middle of the secondary coil of the coupling coil T1 is connected in series with the ninth resistor R9 and then grounded. The phase difference between the two sine alternating current signals output by the secondary coil of the coupling coil T1 is 180°.

3. The high-voltage high-frequency signal generating circuit for mass spectrometry separation according to claim 2, wherein: The power amplification circuit (4) includes a fourth resistor R4, a fifth resistor R5, a sixth resistor R6, a seventh resistor R7, an eighth resistor R8, a tenth resistor R10, an eleventh resistor R11, a thirteenth resistor R13, a fourteenth resistor R14, a fifteenth resistor R15, a tenth capacitor C10, an eleventh capacitor C11, a twelfth capacitor C12, a thirteenth capacitor C13, a first triode Q1, and a second triode Q2. One end of the fourth resistor R4 is the first sine alternating signal input end of the power amplification circuit (4). The other end of the fourth resistor R4 is connected to the ground after being connected in series with the fifth resistor R5. The clamping power supply is connected to the ground after being connected in series with the sixth resistor R6 and the fifth resistor R5 in sequence. One end of the thirteenth resistor R13 is the second sine alternating signal input end of the power amplification circuit (4). The other end of the thirteenth resistor R13 is connected to the ground after being connected in series with the fourteenth resistor R14. The clamping power supply is connected to the ground after being connected in series with the eleventh resistor R11 and the fourteenth resistor R14 in sequence. The tenth capacitor C10 and the eleventh capacitor C11 are connected in parallel. One end of the tenth capacitor C10 and the eleventh capacitor C11 are both connected to the clamping power supply. The other end of the tenth capacitor C10 and the eleventh capacitor C11 are both grounded; The source S of the first triode Q1 is connected to the ground after being connected in series with the eighth resistor R8. The gate G of the first triode Q1 is connected to the ground after being connected in series with the fifth resistor R5. The drain D of the first triode Q1 is connected to the ground after being connected in series with the seventh resistor R7, the twelfth capacitor C12, and the fifth resistor R5 in sequence. The drain D of the first triode Q1 is the first high-power sine alternating signal output end of the power amplification circuit (4). The first high-power sine alternating signal output end of the power amplification circuit (4) is connected to the first high-power sine alternating signal input end of the boost circuit (5); The source S of the second triode Q2 is grounded after being connected in series with the fifteenth resistor R15. The gate G of the second triode Q2 is connected in series between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is connected in series with the tenth resistor R10 and the thirteenth capacitor C13 in sequence and then connected in series between the eleventh resistor R11 and the fourteenth resistor R14. The drain D of the second triode Q2 is the second high-power sine alternating signal output terminal of the power amplification circuit (4), and the second high-power sine alternating signal output terminal of the power amplification circuit (4) is connected to the second high-power sine alternating signal input terminal of the boost circuit (5).

4. The high-voltage high-frequency signal generation circuit for mass spectrometry separation according to claim 3, wherein: The boost circuit (5) includes a second boost coil T2, an eighth capacitor C8, a fifteenth capacitor C15, and an inductor coil L1. One end of the primary coil of the second boost coil T2 is the first high-power sine alternating signal input terminal of the boost circuit (5), and the other end of the primary coil of the second boost coil T2 is the second high-power sine alternating signal input terminal of the boost circuit (5). The middle of the primary coil of the second boost coil T2 is connected to the 24V power supply after being connected in series with the inductor coil L1 and the filter circuit (7) in sequence. One end of the secondary coil of the second boost coil T2 is connected to the first kilovolt sine alternating signal output terminal of the signal generation circuit after being connected in series with the fifteenth capacitor C15. The other end of the secondary coil of the second boost coil T2 is connected to one end of the ninth capacitor C9 after being connected in series with the eighth capacitor C8 in sequence. The other end of the ninth capacitor C9 is the second kilovolt sine alternating signal output terminal of the signal generation circuit.

5. The high-voltage high-frequency signal generation circuit for mass spectrometry separation according to claim 4, wherein: The filter circuit (7) includes a sixteenth capacitor C16, a seventeenth capacitor C17, and an eighteenth capacitor C18. The sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 are all connected in parallel with each other. One end of the sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 is connected in series between the 24V power supply and the inductor coil L1, and the other ends of the sixteenth capacitor C16, the seventeenth capacitor C17, and the eighteenth capacitor C18 are all grounded.

6. The high-voltage high-frequency signal generation circuit for mass spectrometry separation according to claim 5, wherein: The boost multiple of the second boost coil T2 is fifty times.

7. The operation method of the high-voltage high-frequency signal generation circuit for mass spectrometry separation according to any one of claims 1 to 6, wherein: The operation method includes: The first step: Output a square wave signal, turn on the main power supply. The main power supply supplies power to each electrical component in the signal generation circuit. The input level of the Schmitt trigger is zero. At this time, the Schmitt trigger outputs a high-level signal. The high-level signal returns to the input through the first resistor R1 and the second resistor R2, and charges the first capacitor C1. When the first capacitor C1 reaches the first threshold, the output of the Schmitt trigger flips. At this time, the Schmitt trigger outputs a low-level signal, and the first capacitor C1 starts to discharge, causing the input level of the Schmitt trigger to gradually decrease. When the input voltage of the Schmitt trigger is lower than the second threshold, the output of the Schmitt trigger flips again. At this time, a cycle of the square wave signal is completed. Repeat the cycle of the square wave signal and output the square wave signal to the drive circuit (2). At this time, the step of outputting the square wave signal is completed; The second step: Improve the signal driving ability. After the drive circuit (2) receives the square wave signal output by the signal generation circuit, it amplifies the current of the square wave signal to improve the signal driving ability, and outputs the high-drive square wave signal with improved signal driving ability to the coupling circuit (3). At this time, the step of improving the signal driving ability is completed; The third step: Convert the digital signal to an analog signal. After the primary coil in the coupling coil T1 receives the square wave signal sent by the drive circuit (2), the square wave signal is converted into a sinusoidal alternating signal through the coupling coil T1, and the converted sinusoidal alternating signal is equally divided into two signals with equal power through both ends of the secondary coil in the coupling coil T1 and output to the first sinusoidal alternating signal input terminal and the second sinusoidal alternating signal input terminal of the power amplifier circuit (4). At this time, the step of converting the digital signal to an analog signal is completed; The fourth step: Amplify the power of the alternating signal. The sinusoidal alternating signal received by the first sinusoidal alternating signal input terminal in the power amplifier circuit (4) enters the first triode Q1 after passing through the fourth resistor R4. At the same time, the sinusoidal alternating signal received by the second sinusoidal alternating signal input terminal in the power amplifier circuit (4) enters the second triode Q2. When the first triode Q1 and the second triode Q2 receive a negative voltage signal, the corresponding triode is cut off. When the first triode Q1 and the second triode Q2 receive a positive voltage signal, the corresponding triode conducts, amplifying the alternating signal passing through the triode, and outputting it to the boost circuit (5) through the first high-power sinusoidal alternating signal output terminal and the second high-power sinusoidal alternating signal output terminal. At this time, the step of amplifying the power of the alternating signal is completed; The fifth step: Boost the alternating signal. The boost circuit (5) boosts the high-power sinusoidal alternating signal through the second boost coil T2 and outputs the boosted alternating signal to the pole (6) of the linear trap. At this time, the step of boosting the signal is completed.

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