Carbon dioxide aerosol topical skin preparations

Abstract

An aerosol carbonic acid skin external preparation, which is composed of an aerosol base liquid containing components (A) to (C) and a propellant containing component (D), and has a pH value of 4.0 or more and 7.0 or less immediately after being sprayed. (A) heparinoid, (B) water-soluble polymer, (C) water, (D) carbon dioxide.

Description

Technical Field

[0001] This invention relates to a carbonic aerosol topical skin agent. Background Technology

[0002] Heparin-like substances possess multiple hydrophilic groups such as sulfate, carboxyl, and hydroxyl groups in their structure, exhibiting pharmacological effects including moisturizing and anti-inflammatory properties. Topical skin preparations containing heparin-like substances are believed to be effective in treating and preventing thrombophlebitis (including hemorrhoids), pain and inflammatory diseases caused by circulatory disorders (induration and pain after injection), chilblains, hypertrophic scars / keloids, progressive palmar-digital keratoderma, sebaceous agenesis, swelling, hematoma, tenosynovitis, myalgia, arthritis, and muscular torticollis (in infancy) following trauma (bruises, sprains, contusions).

[0003] As dosage forms of topical skin agents containing heparin-like substances, creams, ointments, lotions, and foam sprays are currently on the market. Among these dosage forms, foam sprays are expected to better prevent dripping at the affected area compared to lotions, and are easier to spread on the affected area compared to creams or ointments. For example, Patent Document 1 describes a composition for a screen foamer that can form foam using a screen foamer without using a foaming gas, considering that liquefied natural gas can irritate the skin. This composition contains a heparin-like substance, a nonionic surfactant, and a specific polyol. Patent Document 2 describes a foaming composition consisting of a heparin-like substance, a stock solution containing a specific nonionic surfactant and free of lower alcohols, and a spraying agent.

[0004] On the other hand, carbon dioxide is known to promote blood circulation and has a warming effect, and the industry has been using aerosol-type cosmetics that utilize carbon dioxide as a spray (e.g., Patent Document 3).

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2019-172703

[0008] Patent Document 2: Japanese Patent Application Publication No. 2016-180012

[0009] Patent Document 3: Japanese Patent Application Publication No. 2018-43932 Summary of the Invention

[0010] The present invention provides a carbonated aerosol skin topical agent, which is composed of an aerosol stock solution containing the following components (A) to (C) and a spray containing component (D), and the pH value immediately after spraying is above 4.0 and below 7.0.

[0011] (A) Heparin-like substances,

[0012] (B) Water-soluble polymers,

[0013] (C) Water

[0014] (D) Carbon dioxide. Detailed Implementation

[0015] The composition for a screen foamer described in Reference 1 is difficult to produce fine foam, and friction is easily felt during application. Furthermore, the foaming composition described in Reference 2, due to the use of LPG as the spray agent, presents a problem of skin irritation.

[0016] However, while the surface of human skin maintains a slightly acidic pH as part of homeostasis, the pH of dry skin with inflammation is known to be elevated, especially for topical skin agents containing heparin-like substances. To improve the health of this skin, it is important to use a slightly acidic formulation. However, the compositions described in Patent Documents 1 and 2 produce a foam with a pH in the neutral range, higher than the pH of slightly acidic skin. However, adding a large amount of pH adjuster to make the formulation slightly acidic to improve buffering capacity can cause irritation or tightness to the skin. To address this, using carbonic acid as a spray, as in the cosmetic described in Patent Document 3, can suppress irritation or tightness and adjust the pH to slightly acidic. However, it is known that such formulations release carbon dioxide upon spraying, thereby increasing the pH to near neutral. Furthermore, it is desirable to reduce friction during application and spread on the skin to minimize physical irritation.

[0017] The inventors have discovered that by using carbon dioxide as a propellant and containing heparin-like substances and water-soluble polymers in the stock solution, the above-mentioned problems can be solved.

[0018] The carbonic aerosol skin topical agent of the present invention causes less skin irritation or tightness, is easy to apply and spread, and maintains a slightly acidic pH after spraying.

[0019] Aerosol stock solution

[0020] The aerosol stock solution in the carbonated aerosol skin topical agent of the present invention contains the following components (A) to (C).

[0021] [Ingredient (A): Heparin-like substance]

[0022] The heparinoid substance in component (A) is also known as a mucopolysaccharide polysulfate or heparinoid, and is formed by polysulfating a mucopolysaccharide with a repeating unit consisting of a disaccharide composed of D-glucuronic acid and N-acetyl-D-galactosamine. Preferably, the heparinoid substance is one described in the Japanese Pharmacopoeia Standard for Non-Pharmaceutical Products 2002.

[0023] There is no particular limitation on the average molecular weight of the heparin-like substance, but from the viewpoint of medicinal effects such as moisturizing, it is preferably 1,000 to 1,000,000 Mw, and particularly preferably 5,000 to 100,000 Mw. Furthermore, there is no particular limitation on the amount (%) of organosulfate groups in the heparin-like substance, but from the viewpoint of medicinal effects such as moisturizing, it is preferably 20 to 40%, and more preferably 25 to 38%. Moreover, the amount of organosulfate groups is determined using the method described in the "Heparin-like Substances" section of the Japanese Pharmacopoeia Standard for Non-Pharmaceutical Products 2002.

[0024] From the viewpoint of efficacy such as moisturizing effect and user experience, the content of component (A) in the aerosol stock solution is preferably 0.05% by mass or more, more preferably 0.07% by mass or more, and even more preferably 0.1% by mass or more; furthermore, it is preferably 0.6% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.4% by mass or less. The specific range of the content of component (A) in the aerosol stock solution is preferably 0.05 to 0.6% by mass, more preferably 0.07 to 0.5% by mass, and even more preferably 0.1 to 0.4% by mass.

[0025] [Ingredient (B): Water-soluble polymer]

[0026] The water-soluble polymer used as component (B) is not limited to any commonly used topical skin preparations, and examples include: plant-based polymers, microbial polymers, mucopolysaccharides, cellulose polymers, starch polymers, vinyl polymers, acrylic polymers, and polyoxyethylene polymers. The weight-average molecular weight of the water-soluble polymer in component (B) is preferably 10,000 or higher. The weight-average molecular weight is determined using a gel permeation chromatography (GPC)-multi-angle laser scattering detection (MALLS) system with polyethylene oxide as the standard substance.

[0027] Furthermore, from the viewpoint of maintaining the weakly acidic nature of the sprayed agent, the viscosity of a 2% by mass aqueous solution of component (B) at 20°C is preferably 5 mPa·s or more, more preferably 10 mPa·s or more, and even more preferably 20 mPa·s or more; furthermore, from the viewpoint of improving sprayability, it is preferably 100,000 mPa·s or less, more preferably 8,000 mPa·s or less, and even more preferably 5,000 mPa·s or less. Moreover, the viscosity is measured at 20°C using a Type B viscometer (e.g., VISCOMETER TVB-10, manufactured by Toki Sangyo Co., Ltd.).

[0028] Examples of plant-based polymers include: gum arabic, locust bean gum, guar gum, ebony gum, carrageenan, pectin, agar, and starch (from rice, corn, potatoes, and wheat). Examples of microbial polymers include: xanthan gum and gellan gum. Examples of mucopolysaccharides include: hyaluronic acid, tuberose polysaccharides, and tremella polysaccharides. Examples of cellulose polymers include: methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose stearyl ether, nitrocellulose, sodium cellulose sulfate, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, and sodium hydroxypropyl sulfonate of hydroxyethylcellulose hydroxypropyl cellulose stearyl ether. Examples of starch polymers include: carboxymethyl starch and methyl hydroxypropyl starch. Examples of vinyl polymers include: polyvinyl methyl ether and polyvinylpyrrolidone. Examples of acrylic polymers include: sodium polyacrylate, ethyl polyacrylate, polyacrylamide, acrylic acid / (meth)acrylate alkyl ester copolymer, (sodium acrylate / sodium acryloyldimethyl taurate) copolymer, polyacrylate crosslinker-6, 2-methacryloyloxyethyl phosphocholine / butyl methacrylate copolymer, etc. Examples of polyoxyethylene polymers include: polyethylene oxide, etc.

[0029] From the viewpoint of maintaining the weakly acidic nature of the sprayed agent and reducing friction during application, water-soluble polymers with a sugar backbone, such as plant polymers, microbial polymers, mucopolysaccharides, cellulose polymers, and starch polymers, are preferred, cellulose polymers are more preferred, and hydroxypropyl methylcellulose, hydroxypropyl methylcellulose stearoxy ether, and hydroxyethyl cellulose are even more preferred.

[0030] From the viewpoint of maintaining the weakly acidic nature of the sprayed agent and reducing friction during application, the content of component (B) in the aerosol stock solution is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.10% by mass or more, and even more preferably 0.20% by mass or more; furthermore, it is preferably 5.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 1.0% by mass or less, and even more preferably 0.80% by mass or less. The specific range of the content of component (B) in the aerosol stock solution is preferably 0.01 to 5.0% by mass, more preferably 0.05 to 2.0% by mass, even more preferably 0.10 to 1.0% by mass, and even more preferably 0.20 to 0.80% by mass.

[0031] From the viewpoint of improving the uniformity of the agent and enhancing the user experience during application, the mass ratio (A) / (B) of component (A) to component (B) in the aerosol stock solution is preferably 0.01 or more, more preferably 0.03 or more, and even more preferably 0.1 or more; furthermore, it is preferably 60 or less, more preferably 10 or less, and even more preferably 4 or less. The specific range of the mass ratio (A) / (B) of component (A) to component (B) in the aerosol stock solution is preferably 0.01 to 60, more preferably 0.03 to 10, and even more preferably 0.1 to 4.

[0032] [Ingredient (C): Water]

[0033] The water content of component (C) in the aerosol stock solution is preferably 10% by mass or more, more preferably 20% by mass or more, and even more preferably 40% by mass or more, from the viewpoint of the skin penetration of the sprayed agent and the solubility of heparin-like substances or other components; furthermore, it is preferably 90% by mass or less, more preferably 85% by mass or less, and even more preferably 80% by mass or less. The specific range of the content of component (C) in the aerosol stock solution is preferably 10 to 90% by mass, more preferably 20 to 85% by mass, and even more preferably 40 to 80% by mass.

[0034] [Ingredient (E): Specific pH adjuster]

[0035] The aerosol solution may further contain one or more pH adjusters selected from organic acids, organic acid salts, amino acids, amino acid salts, amines, and inorganic acids, inorganic acid salts, and inorganic bases. Examples of organic acids include glycolic acid, citric acid, malic acid, succinic acid, tartaric acid, and lactic acid; examples of their salts include potassium salts and sodium salts. Examples of amino acids include glutamic acid, aspartic acid, arginine, and lysine; examples of their salts include sodium salts, hydrochlorides, and succinates. Examples of amines include monoethanolamine, triethanolamine, methylamine, ethylamine, trimethylamine, triethylamine, ethylenediamine, tetramethylethylenediamine, and other aliphatic amines. Examples of inorganic acids include phosphoric acid; examples of inorganic acid salts include potassium dihydrogen phosphate and disodium hydrogen phosphate. Examples of inorganic bases include alkali metal hydroxides such as lithium hydroxide, sodium hydroxide, and potassium hydroxide. From the perspective of improving the stability of heparin-like substances, organic acids, organic acid salts, amino acids, amino acid salts, amines, and inorganic bases are preferred.

[0036] From the viewpoint of the stability of heparin-like substances, the content of component (E) in the aerosol stock solution is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more; furthermore, from the viewpoint of reducing skin irritation or tightness, it is preferably 0.7% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.4% by mass or less. The specific range of the content of component (E) in the aerosol stock solution is preferably 0.01 to 0.7% by mass, more preferably 0.05 to 0.5% by mass, and even more preferably 0.1 to 0.4% by mass.

[0037] From the viewpoint of reducing skin irritation or tightness, the mass ratio (A) / (E) of component (A) to component (E) in the aerosol stock solution is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more; furthermore, it is preferably 60 or less, more preferably 10 or less, and even more preferably 4 or less. The specific range of the mass ratio (A) / (E) of component (A) to component (E) in the aerosol stock solution is preferably 0.05 to 60, more preferably 0.1 to 10, and even more preferably 0.2 to 4.

[0038] From the viewpoint of maintaining the weakly acidic nature of the aerosol stock solution, the mass ratio (B) / (E) of component (B) to component (E) is preferably 0.01 or more, more preferably 0.1 or more, and even more preferably 0.2 or more; furthermore, it is preferably 500 or less, more preferably 40 or less, and even more preferably 2.5 or less. The specific range of the mass ratio (B) / (E) of component (B) to component (E) in the aerosol stock solution is preferably 0.01 to 500, more preferably 0.1 to 40, and even more preferably 0.2 to 2.5.

[0039] From the viewpoint of reducing skin irritation or tightness, the mass ratio (D) / (E) of component (D) to component (E) in the aerosol stock solution is preferably 0.01 or more, more preferably 0.2 or more, further preferably 2.5 or more, further preferably 3.0 or more, and further preferably 3.5 or more. Furthermore, from the viewpoint of the stability of the heparin-like substance, it is preferably 500 or less, more preferably 60 or less, further preferably 30 or less, further preferably 15 or less, and further preferably 10 or less. The specific range of the mass ratio (D) / (E) of component (D) to component (E) in the aerosol stock solution is preferably 0.01 to 500, more preferably 0.2 to 60, further preferably 2.5 to 30, further preferably 3.0 to 15, and further preferably 3.5 to 10.

[0040] [Any other ingredients]

[0041] Aerosol solutions can also appropriately incorporate ingredients commonly used in topical skin preparations as other components besides those mentioned above. Examples of such components include: oils that are liquid at 25°C, polyols, thickeners, preservatives, powders, ethanol, antioxidants, pigments, fragrances, moisturizers, blood circulation promoters, cooling agents, antiperspirants, bactericides, whitening agents, anti-inflammatory agents, and skin activators. Furthermore, these agents are not limited to their intended use and can be repurposed or combined with other uses depending on the purpose. For example, an antiperspirant can be used as a fragrance, or as an agent that combines the effects of both antiperspirants and fragrances.

[0042] The polyol can be any commonly used in cosmetics, such as: ethylene glycol, propylene glycol, propanediol, 1,3-butanediol, 1,3-propanediol, dipropylene glycol, polyethylene glycol, polypropylene glycol, and other binary polyols; and glycerin, sorbitol, and other trivalent or higher polyols. From the viewpoint of improving the penetration and even application of the sprayed agent into the skin, glycerin and binary polyols are preferred; more preferably, glycerin, propylene glycol, propanediol, 1,3-butanediol, 1,3-propanediol, and dipropylene glycol are preferred; even more preferably, glycerin, 1,3-propanediol, and dipropylene glycol are preferred; and even more preferably, glycerin and dipropylene glycol are also preferred.

[0043] From the viewpoint of improving the penetration and even application of the sprayed agent into the skin, the polyol content in the aerosol stock solution is preferably 1% by mass or more, more preferably 2% by mass or more, further preferably 5% by mass or more, and even more preferably 10% by mass or more; additionally, it is preferably 50% by mass or less, more preferably 40% by mass or less, further preferably 30% by mass or less, and even more preferably 20% by mass or less. The specific range of polyol content in the aerosol stock solution is preferably 1 to 50% by mass, more preferably 2 to 40% by mass, further preferably 5 to 30% by mass, and even more preferably 10 to 20% by mass.

[0044] • Propellant

[0045] [Component (D): Carbon Dioxide]

[0046] In this invention, carbon dioxide containing component (D) is used as the propellant. Other propellants besides carbon dioxide can also be used in combination. Examples of propellants other than carbon dioxide include: liquefied petroleum gas (ethane, propane, ethylene, isobutane, n-butane, propylene, etc., and mixtures thereof (e.g., mixtures of isobutane and propane, propane and butane, etc.), ether propellants (dimethyl ether, etc.), fluorocarbons (fluorocarbons, chlorofluorocarbons, bromochlorofluorocarbons, etc.), compressed gases (nitrogen, air, and mixtures thereof), and chlorofluorocarbons (monochlorodifluoroethane, tetrafluoroethane, etc.), among which nitrogen, dimethyl ether, and liquefied petroleum gas are preferred. When carbon dioxide containing component (D) is used in combination with other propellants, any one can be used alone or in combination of two or more.

[0047] When using a propellant other than carbon dioxide (component D) as the propellant, from the viewpoint of not impairing the effect of carbon dioxide, the ratio of carbon dioxide (component D) in all propellants, based on the volume of gaseous state (1013.25 hPa, 25°C), is preferably 20% or more, more preferably 40% or more, further preferably 60% or more, and even more preferably 80% or more.

[0048] Carbonated aerosol skin treatment

[0049] The carbonated aerosol topical skin agent of the present invention can be manufactured by preparing an aerosol stock solution containing components (A) to (C), and filling it together with a spray containing component (D) into a pressure-resistant container. As for its spray form, a foam type that is sprayed in a bubble-like manner is preferred.

[0050] From the viewpoint of improving the solubility, foam viscosity, and sprayability of carbon dioxide relative to 100 parts by mass of the aerosol stock solution, the ratio of (D) carbon dioxide is preferably 0.01 parts by mass or more, more preferably 0.10 parts by mass or more, even more preferably 0.125 parts by mass or more, even more preferably 0.25 parts by mass or more, even more preferably 0.5 parts by mass or more, and even more preferably 1.0 parts by mass or more; furthermore, it is preferably 5.0 parts by mass or less, and even more preferably 3.0 parts by mass or less.

[0051] The aerosol topical skin agent of the present invention has a pH value of 4.0 to 7.0 immediately after spraying. To adjust the pH value to this range, a pH adjuster of the above-mentioned component (E) can be used. The pH value immediately after spraying is preferably 4.5 or higher, more preferably 5.0 or higher; furthermore, it is preferably 6.5 or lower, more preferably 6.0 or lower. In the present invention, the pH value immediately after spraying refers to the pH value measured 1 minute after spraying from the aerosol container at 25°C.

[0052] When the carbonated aerosol skin topical agent of the present invention is a foam type, the viscosity of the sprayed foam is preferably 0.1 Pa·s or more, more preferably 0.5 Pa·s or more, and even more preferably 1.0 Pa·s or more, from the viewpoint of maintaining weak acidity; furthermore, it is preferably 50 Pa·s or less, more preferably 40 Pa·s or less, and even more preferably 30 Pa·s or less. Here, the viscosity of the sprayed foam is measured using a Type B viscometer (e.g., VISCOMETER TVB-10, manufactured by Toki Sangyo Co., Ltd.) under the conditions of rotor No. 3, 12 rpm, 25°C, and 10 seconds.

[0053] [How to use]

[0054] Apply an appropriate amount of the carbonated aerosol skin agent of the present invention to the skin, specifically the skin of the whole body excluding the scalp, preferably any part of the face, body, limbs, etc., more preferably the skin of the hands and feet. It can be taken into the hands and then applied to the target area, or it can be sprayed directly onto the target area. In the case of a foam type, it is preferable to take it into the hands and apply it without breaking the foam. It is particularly preferred to apply it to areas with thicker stratum corneum and prone to dryness, such as the hands, feet, fingers or toes, heels, elbows, and knees. Regarding the amount applied, approximately 1g is preferred when using both hands.

[0055] Regarding the above-described embodiments, preferred embodiments of the present invention are further disclosed below.

[0056] <1> A carbonic aerosol skin topical agent, comprising an aerosol stock solution containing the following components (A) to (C) and a spray containing component (D), wherein the pH value immediately after spraying is above 4.0 and below 7.0.

[0057] (A) Heparin-like substances,

[0058] (B) Water-soluble polymers,

[0059] (C) Water

[0060] (D) Carbon dioxide.

[0061] <2> The carbonic aerosol skin preparation as described in <1>, wherein the content of component (A) in the aerosol stock solution is preferably 0.05% by mass or more, more preferably 0.07% by mass or more, and even more preferably 0.1% by mass or more; in addition, it is preferably 0.6% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.4% by mass or less.

[0062] <3> The carbonic aerosol skin preparation as described in <1> or <2>, wherein component (B) is preferably selected from one or more of plant-based polymers, microbial polymers, mucopolysaccharides, cellulose polymers, starch polymers, vinyl polymers, acrylic polymers, and polyoxyethylene polymers, more preferably selected from one or more of water-soluble polymers having a sugar backbone, further preferably selected from one or more of cellulose polymers, and even more preferably selected from one or more of hydroxypropyl methylcellulose, hydroxypropyl methylcellulose stearoxy ether, and hydroxyethyl cellulose.

[0063] <4> The carbonic aerosol skin preparation as described in any one of <1> to <3>, wherein the viscosity of a 2% by mass aqueous solution of component (B) at 20°C is preferably 5 mPa·s or more, more preferably 10 mPa·s or more, and even more preferably 20 mPa·s or more; furthermore, it is preferably 100,000 mPa·s or less, more preferably 8,000 mPa·s or less, and even more preferably 5,000 mPa·s or less.

[0064] <5> The carbonic acid aerosol skin preparation as described in any one of <1> to <4>, wherein the content of component (B) in the aerosol stock solution is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.10% by mass or more, even more preferably 0.20% by mass or more; furthermore, it is preferably 5.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 1.0% by mass or less, even more preferably 0.80% by mass or less.

[0065] <6> The carbonic aerosol skin preparation as described in any one of <1> to <5>, wherein the mass ratio (A) / (B) of component (A) to component (B) in the aerosol stock solution is preferably 0.01 or more, more preferably 0.03 or more, and even more preferably 0.1 or more; furthermore, it is preferably 60 or less, more preferably 10 or less, and even more preferably 4 or less.

[0066] <7> The carbonic aerosol skin preparation as described in any one of <1> to <6>, wherein the content of component (C) in the aerosol stock solution is preferably 10% by mass or more, more preferably 20% by mass or more, and even more preferably 40% by mass or more; furthermore, it is preferably 90% by mass or less, more preferably 85% by mass or less, and even more preferably 80% by mass or less.

[0067] <8> Carbonated aerosol skin preparation as described in any one of <1> to <7>, wherein, preferably, the aerosol stock solution further contains one or more pH adjusters selected from organic acids, organic acid salts, amino acids, amino acid salts, amines, and inorganic bases as ingredients (E).

[0068] <9> The carbonic aerosol skin preparation as described in any one of <1> to <8>, wherein the content of component (E) in the aerosol stock solution is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more; furthermore, it is preferably 0.7% by mass or less, more preferably 0.5% by mass or less, and even more preferably 0.4% by mass or less.

[0069] <10> The carbonic aerosol skin preparation as described in <8> or <9>, wherein the mass ratio (A) / (E) of component (A) to component (E) in the aerosol stock solution is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more; furthermore, it is preferably 60 or less, more preferably 10 or less, and even more preferably 4 or less.

[0070] <11> The carbonic aerosol skin preparation as described in any one of <8> to <10>, wherein the mass ratio (B) / (E) of component (B) to component (E) in the aerosol stock solution is preferably 0.01 or more, more preferably 0.1 or more, and even more preferably 0.2 or more; furthermore, it is preferably 500 or less, more preferably 40 or less, and even more preferably 2.5 or less.

[0071] <12> The carbonic aerosol skin preparation as described in any one of <1> to <11>, wherein, preferably, the aerosol stock solution further contains a polyol.

[0072] <13> The carbonic aerosol skin preparation as described in <12>, wherein the polyol preferably includes one or more selected from glycerin and dihydric polyols, more preferably includes one or more selected from glycerin, propylene glycol, propanediol, 1,3-butanediol, 1,3-propanediol and dipropylene glycol, even more preferably includes one or more selected from glycerin, 1,3-propanediol and dipropylene glycol, and even more preferably includes glycerin and dipropylene glycol.

[0073] <14> The carbonic aerosol skin preparation as described in <12> or <13>, wherein the content of polyol in the aerosol stock solution is preferably 1% by mass or more, more preferably 2% by mass or more, even more preferably 5% by mass or more, even more preferably 10% by mass or more; furthermore, it is preferably 50% by mass or less, more preferably 40% by mass or less, even more preferably 30% by mass or less, even more preferably 20% by mass or less.

[0074] <15> The carbonic acid aerosol skin preparation as described in any one of <1> to <14>, wherein the ratio of component (D) relative to 100 parts by weight of the aerosol stock solution is preferably 0.01 parts by weight or more, more preferably 0.10 parts by weight or more, even more preferably 0.125 parts by weight or more, even more preferably 0.25 parts by weight or more, even more preferably 0.5 parts by weight or more, even more preferably 1.0 parts by weight or more; furthermore, it is preferably 5.0 parts by weight or less, even more preferably 3.0 parts by weight or less.

[0075] <16> The carbonic aerosol skin preparation as described in any one of <1> to <15>, wherein the pH value immediately after spraying is preferably 4.5 or higher, more preferably 5.0 or higher; and preferably 6.5 or lower.

[0076] <17> Carbonated aerosol skin preparation as described in any one of <1> to <16>, wherein it is preferably sprayed in a foam form.

[0077] Example

[0078] Examples 1-19, Comparative Examples 1-4

[0079] Prepare the aerosol stock solution according to the formula shown in Tables 1-2, and fill it together with the propellant (carbon dioxide or LPG) into an aluminum pressure-resistant container to obtain aerosol skin cosmetics.

[0080] For these aerosol skin cosmetics, the persistence of pH value after spraying, foam quality, and user experience during application were evaluated according to the following methods and benchmarks.

[0081] <pH value immediately after spraying>

[0082] At 25°C, after spraying the aerosol topical skin agent from a pressure-resistant container, take about 5g and put it into a 20mL plastic cup. One minute after spraying, use a pH meter (LAQUA F-74) to measure the pH value.

[0083] <Persistence of pH value>

[0084] At 25°C, after spraying the aerosol topical skin agent from a pressure-resistant container, approximately 5g was placed into a 20mL plastic cup and stirred at 200rpm for 5 minutes. The pH value was then measured using a pH meter (LAQUA F-74). The difference between this measured value and the pH value immediately after spraying was defined as ΔpH, and the determination was made as follows.

[0085] A: ΔpH≤0.5

[0086] B: 0.5 < ΔpH ≤ 1.0

[0087] C: 1.0 < ΔpH ≤ 1.5

[0088] D: 1.5 < ΔpH

[0089] X: The pH level is high immediately after spraying.

[0090] <Foam>

[0091] Approximately 1g of aerosol skin agent was sprayed from a pressure-resistant container onto the palm. The appearance of the foam after 10 seconds was evaluated by 5 professional evaluators based on the criteria of fine foam (2 points), coarse foam (1 point), and no foam (0 points). The total evaluation scores are shown in the table.

[0092] <The feeling of using it when applying>

[0093] 0.5g of the aerosol topical agent sprayed from the pressure-resistant container was applied to the forearm. The tactile sensation when spreading it on the palm of the untreated side was evaluated by 5 professional evaluators based on the following criteria: smooth spread on the skin without friction (2 points) / slightly smooth spread on the skin with slight friction (1 point) / difficult to spread on the skin with friction (0 points). The total evaluation scores are shown in the table.

[0094] <Tightness>

[0095] Apply 0.5g of the aerosol skin treatment sprayed from the pressure-resistant container to the forearm. Five professional evaluators evaluated the skin feel 5 minutes after application, based on whether the skin felt no tightness (2 points), almost no tightness (1 point), or tightness (0 points). The total scores are shown in the table.

[0096]

[0097] [Table 2]

[0098]

[0099] *1: Metalose 90SH-15000 (manufactured by Shin-Etsu Chemical Co., Ltd.)

[0100] *2: Metalose 60SH-4000 (manufactured by Shin-Etsu Chemical Co., Ltd.)

[0101] *3: Sangelose 90L (manufactured by Daido Chemical Industry Co., Ltd.)

[0102] *4: Natrosol 250HX PHARM (manufactured by Ashland)

[0103] *5: ALKOX E-100 (manufactured by Mingcheng Chemical Industry Co., Ltd.)

[0104] *6: CMC DAICEL 1150 (manufactured by DAICEL MIRAIZU Ltd.)

[0105] *7: Carbopol 980 (manufactured by Lubrizol Advanced Materials Inc.)

[0106] *8: Pemulen TR-1 (manufactured by Lubrizol Advanced Materials Inc.)

[0107] *9: Echo Gum T (manufactured by DSP Gokyo Food & Chemical Co., Ltd.) *10: Lipidure PMB (manufactured by Nichiyu Corporation)

Claims

1. A carbonated aerosol topical skin agent, wherein, It consists of an aerosol stock solution containing the following components (A) to (C) and a spray containing component (D), and the pH value immediately after spraying is between 4.0 and 7.

0. (A) Heparin-like substances, (B) Contains 0.05 to 5.0% by mass of one or more water-soluble polymers selected from hydroxypropyl methylcellulose. (C) Water (D) Carbon dioxide, The carbon dioxide ratio of component (D) in all propellants is 100% based on the volumetric standard of gaseous state at 1013.25 hPa and 25°C.

2. The carbonic acid aerosol topical skin agent as described in claim 1, wherein, The content of component (A) in the aerosol stock solution is 0.05~0.6% by mass.

3. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The viscosity of a 2% aqueous solution of component (B) at 20°C is 5~100000 mPa·s.

4. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The content of component (B) in the aerosol stock solution is 0.1~2.0 by mass.

5. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The mass ratio (A) / (B) of component (A) to component (B) in the aerosol stock solution is 0.01 to 60.

6. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The content of component (C) in the aerosol stock solution is 10~90% by mass.

7. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, Furthermore, the aerosol stock solution contains one or more pH adjusters selected from organic acids, organic acid salts, amino acids, amino acid salts, amines, and inorganic bases as components (E).

8. The carbonic acid aerosol topical skin agent as described in claim 7, wherein, The content of component (E) in the aerosol stock solution is 0.01~0.7% by mass.

9. The carbonic acid aerosol topical skin agent as described in claim 7, wherein, The mass ratio (A) / (E) of component (A) to component (E) in the aerosol stock solution is 0.05 to 60.

10. The carbonic aerosol topical skin agent as described in claim 7, wherein, The mass ratio (B) / (E) of component (B) in the aerosol stock solution is 0.01 to 500.

11. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The aerosol stock solution further contains polyols.

12. The carbonic aerosol skin agent as described in claim 11, wherein, Polyols include one or more selected from glycerol and dihydric polyols.

13. The carbonic acid aerosol topical skin agent as described in claim 11, wherein, The polyol content in the aerosol stock solution is 1-50% by mass.

14. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The ratio of component (D) to 100 parts by weight of aerosol stock solution is 0.01 to 5.0 parts by weight.

15. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, The pH value immediately after spraying is 4.5~6.

5.

16. The carbonic acid aerosol topical skin agent as described in claim 1 or 2, wherein, It is sprayed out in a bubble-like form.

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