A BSL-3 laboratory

Abstract

The application discloses a BSL-3 laboratory, which comprises a laboratory module and an auxiliary module, the laboratory module is formed by sequentially and detachably splicing a buffer room module and a plurality of shelter modules, the auxiliary module is equipped with air supply and exhaust units and guarantee units, and the buffer room module and the shelter modules are connected with the units on the auxiliary module to normally work. Compared with the prior art, the application has the following advantages: the technical indexes of the buffer room module and the shelter modules are designed and constructed by adopting unified standards on the basis of meeting the relevant mandatory provisions of the state; quick expansion or layout change can be realized by configuring different types of buffer room modules; the auxiliary module is equipped with a plurality of air supply and exhaust units with uniform pressure, each module corresponds to an air supply and exhaust unit, and the air supply and exhaust units of adjacent modules can be used as backup for each other, so that when air supply and exhaust faults occur in any module, the module with the faults can be ensured to not cause sharp pressure change or even pressure reversal.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biosafety laboratory, and particularly to a BSL-3 laboratory. BACKGROUND

[0002] Since the 21st century, major infectious diseases such as SARS, H1N1, MERS, Ebola, and SARS-CoV-2 have had a huge impact on the life and production order of human civilization, and have posed great challenges to global trade, people's health, and national security. High-level biosafety laboratories are one of the important infrastructures for researching and preventing these major infectious diseases, and are of great significance in the prevention and control of severe infectious diseases, biological defense, and anti-bioterrorism.

[0003] Most of the existing BSL-3 (Biological safety protection third-level) laboratories are modified from containers, and are divided into multiple experimental modules according to the types of experimental operations required. Although these BSL-3 laboratories have certain short-distance moving and self-loading and unloading functions, the size and function of each experimental module are relatively fixed, and the layout is limited. It is not only inconvenient to disassemble but also once disassembled, it will affect the overall operation of the laboratory, and even threaten the biological safety. Therefore, it cannot be flexibly configured according to different working environments, and in the face of a large-scale outbreak of the epidemic, it can only increase the number of BSL-3 laboratories to improve the on-site testing capacity. However, increasing the number of BSL-3 laboratories will cause unreasonable allocation of resources, resulting in some experimental modules with heavy workloads and some experimental modules with excess capacity, which weakens the effectiveness of the BSL-3 laboratory. SUMMARY

[0004] The purpose of the present application is to provide a BSL-3 laboratory that can be flexibly configured according to different working environments, thereby solving the problems of limited layout, fixed form, and unreasonable allocation of resources of existing BSL-3 laboratories.

[0005] To achieve the above purpose, the present application adopts the following technical solution:

[0006] A BSL-3 laboratory comprises:

[0007] A laboratory module is formed by sequentially detachably connecting a buffer room module and a plurality of square cabin modules with the same or different functions, and the buffer room module and the square cabin module are provided with air supply and exhaust interfaces and water, electricity, and gas interfaces.

[0008] An auxiliary module is provided with a plurality of air supply and exhaust units and a support unit, the air supply and exhaust units and the support unit are respectively provided with a plurality of interfaces, the number of the air supply and exhaust units matches the number of the buffer room modules and the shelter modules, each of the air supply and exhaust units is connected with the air supply and exhaust interface of the buffer room module or one of the shelter modules, the maximum power of the air supply and exhaust units can at least meet the negative pressure requirement of two of the shelter modules, the buffer room modules and the shelter modules are adapted to be connected with the interfaces of the support unit through the water, electricity and gas interfaces thereof to normally work.

[0009] Preferably, the buffer room module comprises a straight-in straight-out buffer room module, a straight-in left-out buffer room module and a straight-in right-out buffer room module.

[0010] Preferably, the shelter module comprises at least one of an experiment module, a biological safety cabinet module and a high-pressure sterilization module, and the experiment module, the biological safety cabinet module and the high-pressure sterilization module are respectively provided with corresponding experiment instruments.

[0011] Preferably, the experiment module is provided with an experiment operation side table and a refrigerator.

[0012] Preferably, the biological safety cabinet module is provided with an operation cabinet, an ultraviolet lamp disinfection device, a refrigerator, a fluorescent quantitative PCR instrument and a nucleic acid automatic analyzer, and the operation cabinet is provided with an air flow control and high-efficiency air filtration device.

[0013] Preferably, the high-pressure sterilization module is provided with a high-pressure sterilization pot, a safety container classification device and an ultraviolet lamp disinfection device.

[0014] Preferably, the support unit comprises a power distribution unit and a water treatment unit.

[0015] Preferably, the buffer room module, the shelter module and the auxiliary module are respectively provided with a mobile lifting mechanism.

[0016] Preferably, the auxiliary module is further provided with a plurality of function rooms.

[0017] Compared with the prior art, the present application has the following beneficial effects:

[0018] (1) the BSL-3 laboratory according to different functions is divided into a plurality of different independent modules, the technical indicators of the buffer room module and each cabin module are designed and constructed according to a unified size standard on the basis of meeting the mandatory provisions of the state about the general requirements of BSL-3 laboratory biological safety, each module can quickly start normal work after being connected with the air supply and exhaust unit and the support unit on the auxiliary module through the air supply and exhaust interface and the water, electricity and gas interface on the module, when used, the corresponding modules can be selected according to different experimental environments and experimental requirements for targeted combination, so as to improve the working efficiency of the BSL-3 laboratory and the rationality of experimental resource allocation, thereby solving the problems of layout limitation, fixed form and unreasonable resource allocation of the existing BSL-3 laboratory;

[0019] (2) the laboratory main body of the application is assembled in a detachable and splicing manner, so that it meets the conditions of long-distance and large-scale passive transportation;

[0020] (3) each module is equipped with a mobile lifting mechanism, so that it can realize autonomous short-distance movement;

[0021] (4) the auxiliary module is equipped with a support unit, which can be selected according to the actual situation of the construction site and deployed to the site together with the laboratory main body;

[0022] (5) the application can appropriately add the number of auxiliary modules, and the support units on the auxiliary modules are equipped with a plurality of interfaces, the support units of different auxiliary modules are standby for each other, and the embarrassment that the whole laboratory stops running due to the failure of a certain unit of the support module of the traditional BSL-3 laboratory can be solved by replacing the unit, which can provide strong support for biological experiments. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the specific embodiments of the application, the drawings needed in the specific embodiments will be briefly introduced. It should be noted that in all the drawings, the elements or parts are not necessarily drawn according to the actual proportion.

[0024] Figure 1 the overall structure schematic diagram of the BSL-3 laboratory in an embodiment of the application (equipped with a straight-in straight-out buffer room module);

[0025] Figure 2 the overall structure schematic diagram of the BSL-3 laboratory in an embodiment of the application (equipped with a straight-in left-out buffer room module);

[0026] Figure 3 the overall structure schematic diagram of the BSL-3 laboratory in an embodiment of the application (equipped with a straight-in right-out buffer room module);

[0027] Figure 4 The overall layout of the experimental module of the BSL-3 laboratory in the embodiment of the present application (2 straight-in left-out buffer room modules are used as the conversion module);

[0028] Figure 5 The overall layout of the experimental module of the BSL-3 laboratory in the embodiment of the present application (2 straight-in left-out buffer room modules and 1 straight-in right-out buffer room module are used as the conversion module);

[0029] Figure 6 The overall structure schematic diagram of the experimental module in the embodiment of the present application;

[0030] Figure 7 The overall structure schematic diagram of the biological safety cabinet module in the embodiment of the present application;

[0031] Figure 8 The overall structure schematic diagram of the high-pressure sterilization module in the embodiment of the present application;

[0032] Figure 9 The overall structure schematic diagram of the auxiliary module in the embodiment of the present application.

[0033] In the figure:

[0034] 1, laboratory main body; 111, straight-in straight-out buffer room module; 112, straight-in left-out buffer room module; 113, straight-in right-out buffer room module; 12, shelter module; 121, experimental module; 1211, experimental operation side table; 122, biological safety cabinet module; 1221, operation cabinet; 123, high-pressure sterilization module; 1231, high-pressure sterilization pot; 13, exhaust room; 2, auxiliary module; 21, air supply and exhaust unit; 22, power distribution unit; 23, water treatment unit; 24, water treatment room; 25, shower room; 26, monitoring room; 27, reagent storage room; 28, power distribution room; 3, mobile lifting mechanism. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical scheme and advantages of the present application clearer, the technical scheme of the present application will be described clearly and completely below in conjunction with the drawings. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0036] In the description of the present application, it should be noted that the terms "upper", "lower", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the systems or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the use of the terms "first", "second" and the like to define parts is only for the convenience of distinguishing the above-mentioned parts, and the above-mentioned terms have no special meaning unless otherwise stated, and cannot be understood as indicating or implying relative importance.

[0037] In the description of the present application, it should be noted that unless otherwise specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integral connection; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through intermediate medium, or the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0038] In the prior art, most of the BSL-3 (Biological safety protection third-level) laboratories are rebuilt from containers, which are partitioned according to the types of experimental operations required to form multiple experimental modules. The size and function of the experimental modules of these BSL-3 laboratories are relatively fixed, and the layout is limited, which is not only inconvenient to disassemble but also once disassembled, it will affect the overall operation of the laboratory, and even seriously threaten the biological safety. Therefore, it generally cannot be flexibly configured according to different working environments, and when facing special situations such as large-scale outbreak of epidemic situation that require large-scale on-site testing capacity, only by increasing the number of BSL-3 laboratories can the on-site testing capacity be improved. However, increasing the number of BSL-3 laboratories will cause unreasonable allocation of resources, resulting in large work load of some experimental modules and surplus capacity of some experimental modules, which weakens the function of BSL-3 laboratories. Therefore, the present application provides a BSL-3 laboratory which can be flexibly configured according to different experimental environments and experimental requirements, thereby solving the problems of layout limitation, form fixation and unreasonable allocation of resources of the existing BSL-3 laboratory.

[0039] Exemplary embodiments of the present application will be described herein below with reference to the accompanying drawings. While exemplary embodiments of the present application are shown in the drawings, it is understood that the present application can be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the present application to those skilled in the art.

[0040] As Figures 1-9 shown, the embodiment of the present application provides a BSL laboratory, which includes a laboratory module 1 and an auxiliary module 2.

[0041] The laboratory module 1 is composed of a buffer room module and a plurality of square cabin modules 12 with the same or different functions which are sequentially detachably spliced. The buffer room module and the square cabin modules 12 are provided with air supply and exhaust interfaces 13 and water, electricity and gas interfaces. The buffer room module mainly plays a role of controlling the contaminated air flow and pressure difference to ensure the cleanliness of the protection zone, and can also serve as a protective clothing changing room. The square cabin modules 12 are used for corresponding experimental operations.

[0042] The auxiliary module 2 is equipped with a plurality of air supply and exhaust units 21 and support units. The air supply and exhaust units 21 and the support units are respectively provided with a plurality of interfaces. The number of the air supply and exhaust units 21 matches the number of the buffer room module and the square cabin modules 12. Each air supply and exhaust unit 21 is connected to the air supply and exhaust interface 13 of the buffer room module or one square cabin module 12 to provide a unified directional air flow and negative pressure environment protection for the buffer room module and the square cabin modules 12. The maximum power of the air supply and exhaust units 21 can at least meet the negative pressure requirements of two square cabin modules 12. The air supply and exhaust pressures of the air supply and exhaust units 21 are uniformly set. The buffer room module and the square cabin modules 12 are adapted to be connected to the interfaces of the support units through the water, electricity and gas interfaces thereof to ensure the water, electricity and gas supply of the buffer room module and the square cabin modules 12. The main role of the auxiliary module 2 is to ensure the normal operation of the laboratory main body 1 and the safety of personnel.

[0043] The embodiment of the present application subdivides the BSL-3 laboratory main body 1 into a plurality of different independent modules according to different functions. Each module can quickly carry out normal work after being connected to the air supply and exhaust units and the support units of the auxiliary module 2 through the air supply and exhaust interfaces 13 and the water, electricity and gas interfaces thereof. During use, the corresponding modules can be selected for targeted combination according to different experimental environments and experimental requirements to improve the working efficiency of the BSL-3 laboratory and the rationality of experimental resource allocation, thereby solving the problems of layout limitation, form solidification and unreasonable resource allocation existing in the existing BSL-3 laboratory.

[0044] Meanwhile, the ventilation units on the auxiliary module 2 of the embodiment are all equipped with multiple interfaces and their maximum power can meet the negative pressure requirements of at least two shelter modules 12, which makes the corresponding ventilation units of the adjacent modules of the laboratory module 1 can be used as backup for each other, and the modules of the laboratory module 1 are changed from the traditional “series connection” to “parallel connection”, so that when any module of the laboratory module 1 has a ventilation failure during use, the ventilation interface 13 of the failed module can be connected to the corresponding ventilation unit 21 of the adjacent module in time, so as to ensure that the failed module will not have a dramatic change in pressure or even a pressure reversal, thereby avoiding the whole laboratory module 1 from stopping running due to the ventilation failure of a certain module, and the failed ventilation unit 21 can be repaired in time.

[0045] In addition, when any shelter module 12 of the laboratory module 1 has a ventilation failure during use, the power of the ventilation unit 21 of the adjacent shelter module 12 corresponding to the failed shelter module 12 can be increased, so that the ventilation unit 21 of the adjacent shelter module 12 is shared by the failed shelter module 12 and its adjacent shelter module 12, so as to ensure that the failed shelter module 12 will not have a dramatic change in pressure or even a pressure reversal in a short time, thereby avoiding the whole laboratory module 1 from stopping running due to the ventilation failure of a certain shelter module 12, and the failed ventilation unit 21 can be repaired in time.

[0046] It can be understood that the number of auxiliary modules 2 can be appropriately increased during use of the embodiment, and the protection units on different auxiliary modules 2 can be used as backup for each other, so that the embarrassment that the whole laboratory stops running due to the failure of a certain protection unit on the auxiliary module 2 of the traditional BSL-3 laboratory can be solved by replacing the unit during use, which can provide strong protection for biological experiments.

[0047] Further, the buffer room modules include a straight-in straight-out buffer room module 111, a straight-in left-out buffer room module 112, and a straight-in right-out buffer room module 113.

[0048] As shown in Figures 1-3 By configuring different types of buffer room modules, the laboratory module 1 can be built according to the actual conditions of the layout site during splicing, which facilitates the rapid expansion and layout change of the laboratory module 1, so that the embodiment can realize both horizontal arrangement and vertical arrangement, thereby effectively improving the layout flexibility of the embodiment.

[0049] Meanwhile, different buffer room modules can be selected as conversion modules for multi-dimensional expansion of the laboratory module 1 during use of the embodiment, which further improves the flexibility of the layout of the embodiment. Exemplarily, Figure 4The layout of the laboratory main body 1 when the laboratory main body 1 is expanded by using two straight-in left-out buffer room modules 111 as the conversion modules is shown in FIG. 1B, Figure 5 The layout of the laboratory main body 1 when the laboratory main body 1 is expanded by using two straight-in left-out buffer room modules 112 and one straight-in right-out buffer room module 113 as the conversion modules is shown in FIG. 1C.

[0050] Further, the shelter module 12 at least includes one of an experiment module 121, a biological safety cabinet module 122 and a high-pressure sterilization module 123, and the experiment module 121, the biological safety cabinet module 122 and the high-pressure sterilization module 123 are respectively equipped with corresponding experimental instruments.

[0051] The experiment module 121 is mainly used for microbial operations that do not cause human or animal diseases, and sample delivery and reagent preparation; the biological safety cabinet module 122 is mainly used for microbial operations that can cause serious human or animal diseases and are relatively easy to directly or indirectly transmit, and for specimen preparation and nucleic acid amplification detection; and the high-pressure sterilization module 123 is mainly used for the classification collection and harmless treatment of pollutants to avoid environmental pollution.

[0052] In actual application, one or more of the above three modules can be selected according to different experimental environments and experimental requirements and assembled with the buffer room module to form the laboratory main body 1. Since the modules of the laboratory main body 1 of the embodiment can be selected as needed, the embodiment can improve the work efficiency of the laboratory and reasonably allocate experimental resources.

[0053] It should be noted that the above three modules are equipped with corresponding experimental instruments according to the experimental operations performed.

[0054] Optionally, as shown in FIG. 1D, Figures 6-8 the experiment module 121 is equipped with an experimental operation side table 12 and a refrigerator; the biological safety cabinet module is equipped with an operation cabinet 1221, an ultraviolet lamp disinfection device, a refrigerator, a fluorescent quantitative PCR instrument and a nucleic acid automatic analyzer, wherein the operation cabinet 1221 has an air flow control and high-efficiency air filtration device; and the high-pressure sterilization module 123 is equipped with a high-pressure sterilization pot 1231, a safety container classification device and an ultraviolet lamp disinfection device.

[0055] Of course, the experimental instruments equipped in the experiment module 121, the biological safety cabinet module and the high-pressure sterilization module 123 are not limited to the above experimental instruments, and appropriate additions or reductions can be made as needed in other embodiments.

[0056] Further, as shown in FIG. 1E, Figure 9 the security unit includes a power distribution unit 22 and a water treatment unit 23.

[0057] It can be understood that the safeguard units on the auxiliary module 2 are not limited to the power distribution unit 22 and the water treatment unit 23, and in some other embodiments, the number of the units can be increased or decreased according to the actual situation of the laboratory building site. For example, when the laboratory building site has good water supply and power supply conditions, the auxiliary module 2 can not be equipped with the power distribution unit 22 and the water treatment unit 23, but can be equipped with other types of safeguard units as needed; when the laboratory building site conditions are relatively poor and the air quality is poor, the auxiliary module 2 can be equipped with an air filtration unit in addition to the power distribution unit 22 and the water treatment unit 23.

[0058] Further, the buffer module, the shelter module 12 and the auxiliary module 2 are respectively equipped with a mobile lifting mechanism 3.

[0059] The laboratory main body 1 of the embodiment is assembled in a detachable and splicing manner and each module is equipped with a mobile lifting mechanism 3, which makes the embodiment not only meet the conditions of long-distance and large-scale passive transportation, but also realize autonomous short-distance movement.

[0060] In order to ensure the normal operation of the protection area and the safety of the experimenters, the auxiliary module 2 of the embodiment is also equipped with several function rooms.

[0061] Optionally, the function rooms include a water treatment room 24, a shower room 25, a monitoring room 26, a reagent storage room 27 and a power distribution room 28.

[0062] Of course, the function rooms on the auxiliary module 2 of the embodiment are not limited to the above-mentioned several types, and in some other embodiments, other types of function rooms can be set according to actual needs to ensure the normal operation of the protection area and the safety of the experimenters.

[0063] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A BSL-3 laboratory, characterized in that, include: Laboratory module (1), which is composed of a buffer room module and several container modules (12) with the same or different functions, which can be disassembled and spliced ​​in sequence. The buffer room module and the container module (12) have air supply and exhaust interfaces (13) and water, electricity and gas interfaces. The auxiliary module (2) is equipped with several supply and exhaust fan units (21) and support units. The supply and exhaust fan units (21) and the support units have multiple interfaces. The number of supply and exhaust fan units (21) matches the number of buffer room modules and container modules (12). Each supply and exhaust fan unit (21) is connected to the supply and exhaust interface (13) of the buffer room module or one container module (12). The maximum power of the supply and exhaust fan unit (21) can meet the negative pressure requirements of at least two container modules (12). The buffer room module and the container module (12) are adapted to connect to the interface of the support unit through the water, electricity and gas interfaces on them to work normally. When any cabin module (12) experiences a ventilation failure during the use of the laboratory module (1), the ventilation interface (13) of the faulty cabin module (12) can be connected to the ventilation fan unit (21) corresponding to the adjacent cabin module (12) in a timely manner. By increasing the power of the ventilation fan unit (21) corresponding to the adjacent cabin module (12) of the faulty cabin module (12), the faulty cabin module (12) and its adjacent cabin module (12) can share the ventilation fan unit (21), ensuring that the faulty cabin module (12) will not experience drastic pressure changes or even pressure reversal in a short period of time. This can prevent the laboratory module (1) from stopping operation due to a ventilation failure of a cabin module (12), and the ventilation fan unit (21) that has failed can be repaired in a timely manner.

2. The BSL-3 laboratory as described in claim 1, characterized in that, The buffer module includes a straight-in-straight-out buffer module (111), a straight-in-left-out buffer module (112), and a straight-in-right-out buffer module (113).

3. The BSL-3 laboratory as described in claim 1, characterized in that, The modular unit (12) includes at least one of an experimental module (121), a biosafety cabinet module (122), and a high-pressure sterilization module (123), and the experimental module (121), the biosafety cabinet module (122), and the high-pressure sterilization module (123) are equipped with corresponding experimental instruments.

4. The BSL-3 laboratory as described in claim 3, characterized in that, The experimental module (121) is equipped with an experimental operating table (1211) and a refrigerator.

5. The BSL-3 laboratory as described in claim 3, characterized in that, The biosafety cabinet module (122) is equipped with an operating cabinet (1221), an ultraviolet lamp disinfection device, a refrigerator, a fluorescence quantitative PCR instrument, and a fully automated nucleic acid analyzer. The operating cabinet (1221) has an airflow control and high-efficiency air filtration device.

6. The BSL-3 laboratory as described in claim 3, characterized in that, The high-pressure sterilization module (123) is equipped with a high-pressure sterilizer (1231), a safety container sorting device, and an ultraviolet lamp disinfection device.

7. The BSL-3 laboratory as described in claim 1, characterized in that, The supporting units include a power distribution unit (22) and a water treatment unit (23).

8. The BSL-3 laboratory as described in claim 1, characterized in that, The buffer module, the container module (12), and the auxiliary module (2) are also equipped with a mobile lifting mechanism (3).

9. The BSL-3 laboratory as described in claim 8, characterized in that, The auxiliary module (2) is also equipped with several functional rooms.

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