A process and equipment for preparing medical biodegradable polymers

Abstract

This invention discloses a process and equipment for preparing medical biodegradable polymers, relating to the field of biomanufacturing technology. The equipment includes: a preparation chamber containing two sets of linear guide rails symmetrically installed. Between the two sets of linear guide rails, from top to bottom, are a biodegradable polymer solution nozzle, a ring electrode ring, and a collection tray. A separation component is installed at the bottom of the preparation chamber, below the collection tray. A dispensing device is located at the bottom of the preparation chamber, to the left of the separation component. The dispensing device can uniformly distribute the biodegradable polymer microspheres in the separation component. This invention achieves automated separation, screening, and collection of biodegradable polymers through the separation component and dispensing device, thereby improving preparation efficiency.

Description

Technical Field

[0001] This invention relates to the field of biomanufacturing technology, specifically to a process and equipment for preparing medical biodegradable polymers. Background Technology

[0002] Microspheres are spherical particles formed by the dispersion or adsorption of drugs in a polymer matrix, typically ranging in diameter from 1 micrometer to 300 micrometers. In recent years, artificially synthesized biodegradable polymeric materials have received considerable attention due to their non-toxicity, non-irritation, good film-forming or spheroidizing properties, high chemical stability, good biocompatibility, and strong controllability. Among these, polylactic acid (PLA), polycaprolactone (PCL), polyglycolic acid (PLGA), and their copolymers are particularly noteworthy, having become the most commonly used carrier materials for preparing sustained-release microspheres. They are widely used in the sustained-release and controlled-release administration of peptides, proteins, and other drugs via injection and non-injection routes. In the pharmaceutical system, polylactic acid (PLA) has become one of the most valued materials in the current biomedical field due to its good biocompatibility and biodegradability. Its degradation products can participate in human metabolism and its properties can be regulated within a wide range by copolymerizing with other monomers. Polycaprolactone (PCL), as a biocompatible and biodegradable medical material, is often used in long-acting sustained-release drug formulations due to its long degradation time. It is particularly suitable for the development and application of microsphere carriers. At the same time, PCL and its composites are also one of the candidate materials for bone tissue engineering scaffolds.

[0003] In existing technologies, the surface of the prepared polymer microspheres carries residual collection liquid, which affects the performance of the polymer microspheres. Furthermore, it is not possible to obtain polymer microspheres of different sizes according to actual needs, which affects the performance and is time-consuming and labor-intensive. We provide a process and equipment for preparing medical biodegradable polymers to solve the above problems. Summary of the Invention

[0004] The purpose of this invention is to provide a process and equipment for preparing medical biodegradable polymers to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: comprising: a preparation box, wherein two sets of linear guide rails are symmetrically installed inside the preparation box, and between the two sets of linear guide rails, from top to bottom, a biodegradable polymer solution nozzle, a ring electrode ring and a collection tray are arranged sequentially; a separation component is installed at the bottom of the preparation box and below the collection tray; and a dispensing device is provided at the bottom of the preparation box and to the left of the separation component, wherein the dispensing device can uniformly dispense the biodegradable polymer microspheres in the separation component.

[0006] Preferably, the electrostatic generator is fixedly connected to the rear end of the inner wall of the preparation box, the biodegradable polymer solution nozzle, the annular electrode ring and the collection tray are electrically connected to the electrostatic generator through several wires, the biodegradable polymer solution nozzle is connected to the solution storage tank through several hoses, and the annular electrode ring is fixedly connected to the outer wall of the rear end of the linear guide rail through the first fixing rod.

[0007] Preferably, the solution storage tank is fixedly connected to the inner wall of the left side of the preparation box, the outer wall of the preparation box is provided with a solution inlet, and the solution storage tank is connected to the solution inlet. The side of the solution storage tank away from the solution inlet is connected to the input end of the pressure pump through a connecting pipe. The pressure pump is fixedly connected to the top of the inner wall of the solution storage tank, and the output end of the pressure pump is connected to the biodegradable polymer solution nozzle through several hoses.

[0008] Preferably, two sets of linear guide rails are fixedly connected to the rear end of the inner wall of the preparation box, and two sets of fixed brackets are symmetrically arranged on the side of the two sets of linear guide rails that are close to each other. The two sets of fixed brackets slide up and down along the two sets of linear guide rails by a linear motor, and the linear motor is installed inside the linear guide rails.

[0009] Preferably, the biodegradable polymer solution nozzle includes: an upper nozzle support and a lower nozzle support, with the upper nozzle support fixedly connected between the two sets of fixed supports, and the lower nozzle support fixedly connected to the lower end of the upper nozzle support, and a plurality of syringes are installed in a ring on the upper nozzle support, with the lower ends of the syringes fixedly penetrating the upper nozzle support and extending to the bottom of the lower nozzle support, and each of the syringes having a plurality of nozzles at one end extending out of the lower nozzle support.

[0010] Preferably, two sets of fixing blocks are fixedly connected to the bottom of the two sets of linear guide rails, the collection tray is fixedly connected to the two sets of fixing blocks, several sets of return nozzles are fixedly arranged around the top of the collection tray, a through hole is opened in the center of the collection tray, the flow nozzle is installed at the bottom center of the collection tray and communicates with the through hole, and the overall shape of the collection tray is funnel-shaped.

[0011] Preferably, the separation device includes: a first support column, a second support column, and a third support column. Two sets of first support columns are fixedly connected to the bottom of the inner wall of the preparation chamber. A U-shaped block is fixedly connected to the top of the two sets of first support columns, and a liquid collection tank is placed inside the U-shaped block. Two sets of second support columns are fixedly connected to the bottom of the inner wall of the preparation chamber, and the two sets of second support columns are located on both sides of the two sets of first support columns. The top of the second support column movably passes through the bottom of the adjusting sleeve, and the adjusting sleeve is movably connected up and down along the outer wall of the second support column. The adjusting sleeve can be fixed to the second support column by connecting bolts. A buffer spring is fixedly connected to the top of the adjusting sleeve. A mounting plate is fixedly connected to the top of the buffer spring. Vibration dials are fixedly connected to the left and right ends of the mounting plate, and a filter screen is installed in the center of the mounting plate. Two sets of third support columns are fixedly connected to the bottom of the inner wall of the preparation chamber, and the two sets of third support columns are located on both sides of the two sets of second support columns. A drive motor is fixedly connected to the top of the third support column. A rotating ring is fixedly sleeved on the output shaft of the drive motor. A ring of vibration dials is provided on the outer wall of the rotating ring, and the vibration dials abut against the vibration dials.

[0012] Preferably, the material distribution device includes: a screening box and a secondary material distribution assembly. The screening box is fixedly connected to the bottom of the inner wall of the preparation box. A microsphere hopper is provided at the top of the screening box, and a drying box is installed inside the microsphere hopper. A second drive motor is installed at the rear end of the inner wall of the screening box, and a feeding tray is fixedly sleeved on the output shaft of the second drive motor. Several material troughs are formed in the feeding tray by several baffles at intervals. A U-shaped cylinder is fixedly connected to the bottom of the inner wall of the screening box. A support column is fixedly connected to the center of the top of the U-shaped cylinder, and a primary material distribution box is rotatably connected to the top of the support column. A primary screen is fixedly connected to the inner wall of the primary material distribution box. The screen has a primary screen as its central axis and is located on the outer wall of the primary distribution box with two discharge ports. A double-headed cylinder is fixedly connected to the inner wall of the horizontal section of the U-shaped cylinder, and the two output ends of the double-headed cylinder are fixedly connected to the same piston head. The piston head is movably connected to the inner wall of the horizontal section of the U-shaped cylinder, and the piston head is movably connected to the inner wall of the vertical section of the U-shaped cylinder. The lower end of the first connecting rod extends movably into the vertical section of the U-shaped cylinder and is fixedly connected to the top of the piston head. The upper end of the first connecting rod is rotatably connected to the bottom of the primary distribution box. Two sets of secondary distribution components are symmetrically arranged on both sides of the U-shaped cylinder.

[0013] Preferably, the secondary material distribution assembly includes: a secondary material distribution box, with a microsphere inlet 2 at the top; a secondary screen, a first guide plate, a tertiary screen, a second guide plate, a quaternary screen, and a third guide plate sequentially installed from top to bottom on the inner wall of the secondary material distribution box, with the secondary, tertiary, and quaternary screens fixedly connected to the inner wall of the secondary material distribution box; the first, second, and third guide plates rotatably connected to the inner wall of the secondary material distribution box; a U-shaped tube 1 connected through to the front outer wall of the secondary material distribution box, with one end of the U-shaped tube 1 positioned at the top of the secondary screen and the other end positioned at the top of the tertiary screen; and a U-shaped tube 2 connected through to the rear outer wall of the secondary material distribution box. One end of U-shaped tube 2 is set at the top of the third-stage screen, and the other end of U-shaped tube 2 is set at the top of the fourth-stage screen. Discharge port 3 and discharge port 5 are connected to the rear outer wall of the secondary distribution box. Discharge port 3 is set at the top of the first guide plate, and discharge port 5 is set at the top of the third guide plate. Discharge port 4 and discharge port 6 are connected to the front outer wall of the secondary distribution box. Discharge port 4 is set at the top of the second guide plate, and discharge port 6 is set at the top of the fourth-stage screen. The bottom of the first guide plate, the second guide plate, and the third guide plate are all equipped with tilt angle adjustment units. The angle adjustment unit includes a motor and a cam. The motor is fixedly installed on the inner wall of the secondary distribution box, and the output end of the motor is fixedly sleeved with a cam.

[0014] This invention also provides a process for preparing a medical biodegradable polymer, used to control the preparation of the medical biodegradable polymer using the aforementioned equipment. The preparation process includes:

[0015] Step 1: Prepare a biodegradable polymer solution and inject the biodegradable polymer solution into the solution storage tank through the solution inlet;

[0016] Step 2: The linear motor is started and drives the biodegradable polymer solution nozzle to move up and down along the linear guide rail through the fixed bracket until the height of the biodegradable polymer solution nozzle from the annular electrode ring is 30cm.

[0017] Step 3: Apply voltage to the nozzle and the ring electrode ring using an electrostatic generator;

[0018] Step 4: Start the pressure pump to discharge the biodegradable polymer solution in the solution storage tank through a syringe, so that the biodegradable polymer solution forms scattered microspheres after passing through the ring electrode ring and falls into the collection tray.

[0019] Step 5: The biodegradable polymer solution in the collection tray is transported to the separation component through the flow nozzle for filtration and separation to form biodegradable polymer balls;

[0020] Step 6: After the biodegradable polymer spheres are conveyed to the distribution device, the distribution device can uniformly distribute the biodegradable polymer microspheres in the separation component.

[0021] Compared with the prior art, the beneficial effects of the present invention are:

[0022] This invention can prepare polymers of different materials and sizes according to requirements, and can be widely used in the medical field. Furthermore, by setting up separation and collection components, it realizes the automated separation and collection of biodegradable polymers, while ensuring that the entire process of preparation, separation and collection of medical biodegradable polymers is carried out in a clean environment. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the main structure of the present invention;

[0024] Figure 2 A three-dimensional schematic diagram of the internal structure of the box is prepared for this invention;

[0025] Figure 3 For the present invention Figure 1 Enlarged schematic diagram of the structure at point A in the middle;

[0026] Figure 4 This is a schematic diagram of the material distribution device in this invention;

[0027] Figure 5 This is a schematic diagram of the internal structure of the primary material distribution box in this invention;

[0028] Figure 6 This is a schematic diagram of the structure of the two-stage material distribution component in this invention;

[0029] Figure 7 This is a schematic diagram of the preparation process in this invention.

[0030] In the diagram: 1. Preparation box; 2. Linear guide rail; 3. Biodegradable polymer solution nozzle; 4. Ring electrode ring; 5. Collection tray; 501. Through hole; 6. Wire; 7. Electrostatic generator; 8. Hose; 9. Solution storage tank; 10. Solution inlet; 11. Connecting pipe; 12. Pressure pump; 13. Fixing bracket; 14. Upper nozzle bracket; 15. Lower nozzle bracket; 16. Syringe; 17. Nozzle; 18. First fixing rod; 19. Fixing block; 20. Return nozzle; 21. Drain nozzle; 22. First support column; 23. U-shaped block; 24. Liquid collection tank; 25. Second support column; 26. Connecting bolt; 27. Adjusting sleeve; 28. Buffer spring; 29. ​​Mounting plate; 30. Vibration dial; 31. Filter screen; 32. Third support column; 33. Drive motor one; 34. Vibration dial; 35. Rotating ring; 36. Screening box; 37. Connecting pump; 38. Microsphere hopper; 381. Drying oven; 39. Drive motor II; 40. Feeding tray; 41. Baffle; 42. Feed trough; 43. Primary distribution box; 44. Discharge port I; 45. Primary screen; 46. Discharge port II; 47. First connecting hose; 48. Support column; 49. Second connecting hose; 50. Double-headed cylinder; 51. Piston head I; 52. U-shaped cylinder; 53. Piston head II; 54. 55. First connecting rod; 56. Secondary material distribution assembly; 57. Secondary material distribution box; 58. Microsphere inlet 2; 59. Secondary screen; 60. First guide plate; 61. Tertiary screen; 62. Secondary guide plate; 63. Quaternary screen; 64. Third guide plate; 65. U-shaped tube 1; 66. U-shaped tube 2; 67. Outlet 3; 68. Outlet 4; 69. Outlet 5; 70. Motor; 71. Cam. Detailed Implementation

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] In the description of this invention, it should be noted that the terms "upper," "lower," "inner," "outer," "front end," "rear end," "both ends," "one end," and "the other end," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0033] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0034] Example 1

[0035] Please see Figure 1-2 and Figure 7 The present invention provides a technical solution comprising: a preparation box 1, wherein two sets of linear guide rails 2 are symmetrically installed inside the preparation box 1, and between the two sets of linear guide rails 2, a biodegradable polymer solution nozzle 3, an annular electrode ring 4 and a collection tray 5 are arranged sequentially from top to bottom; a separation component is installed at the bottom of the preparation box 1 and below the collection tray 5; and a dispensing device is provided at the bottom of the preparation box 1 and to the left of the separation component, wherein the dispensing device can uniformly dispense the biodegradable polymer microspheres in the separation component.

[0036] Preferably, the electrostatic generator 7 is fixedly connected to the rear end of the inner wall of the preparation box 1. The biodegradable polymer solution nozzle 3, the annular electrode ring 4, and the collection tray 5 are electrically connected to the electrostatic generator 7 through several wires 6. The biodegradable polymer solution nozzle 3 is connected to the solution storage tank 9 through several hoses 8. The annular electrode ring 4 is fixedly connected to the outer wall of the rear end of the linear guide rail 2 through the first fixing rod 18.

[0037] Preferably, the solution storage tank 9 is fixedly connected to the inner left wall of the preparation box 1, the outer wall of the preparation box 1 is provided with a solution inlet 10, and the solution storage tank 9 is connected to the solution inlet 10. The side of the solution storage tank 9 away from the solution inlet 10 is connected to the input end of the pressure pump 12 through a connecting pipe 11. The pressure pump 12 is fixedly connected to the top of the inner wall of the solution storage tank 9, and the output end of the pressure pump 12 is connected to the biodegradable polymer solution nozzle 3 through several hoses 8.

[0038] Preferably, two sets of linear guide rails 2 are fixedly connected to the rear end of the inner wall of the preparation box 1, and two sets of fixed brackets 13 are symmetrically arranged on the side of the two sets of linear guide rails 2 that are close to each other. The two sets of fixed brackets 13 slide up and down along the two sets of linear guide rails 2 by a linear motor, and the linear motor is installed inside the linear guide rails 2.

[0039] Preferably, the biodegradable polymer solution nozzle 3 includes: an upper nozzle support 14 and a lower nozzle support 15. The upper nozzle support 14 is fixedly connected between two sets of fixed supports 13. The lower nozzle support 15 is fixedly connected to the lower end of the upper nozzle support 14. A plurality of syringes 16 are installed in a ring on the upper nozzle support 14, and the lower ends of the plurality of syringes 16 are fixedly inserted through the upper nozzle support 14 and extend to the bottom of the lower nozzle support 15. A plurality of nozzles 17 are provided at one end of the plurality of syringes 16 extending out of the lower nozzle support 15.

[0040] Preferably, two sets of fixing blocks 19 are fixedly connected to the bottom of the two sets of linear guide rails 2 respectively, the collection plate 5 is fixedly connected to the two sets of fixing blocks 19, several sets of return nozzles 20 are fixedly arranged around the top of the collection plate 5, a through hole 501 is opened in the center of the collection plate 5, and the flow nozzle 21 is installed at the bottom center of the collection plate 5 and communicates with the through hole 501. The overall shape of the collection plate 5 is funnel-shaped.

[0041] This invention also provides a process for preparing a medical biodegradable polymer, used to control the preparation of the medical biodegradable polymer using the aforementioned equipment. The preparation process includes:

[0042] Step 1: Prepare a biodegradable polymer solution and inject the biodegradable polymer solution into the solution storage tank 9 through the solution inlet 10;

[0043] Step 2: The linear motor is started and drives the biodegradable polymer solution nozzle 3 to move up and down along the linear guide rail 2 through the fixed bracket 13 until the height of the biodegradable polymer solution nozzle 3 from the annular electrode ring 4 is 30cm.

[0044] Step 3: Apply voltage to the nozzle 17 and the annular electrode ring 4 through the electrostatic generator 7;

[0045] Step 4: Start the pressure pump 12 to discharge the biodegradable polymer solution in the solution storage tank 9 through the syringe 16, so that the biodegradable polymer solution forms scattered microspheres after passing through the ring electrode ring 4 and falls into the collection tray 5.

[0046] Step 5: The biodegradable polymer solution in the collection tray 5 is transported to the separation component through the guide nozzle 21 for filtration and separation to form biodegradable polymer balls;

[0047] Step 6: After the biodegradable polymer spheres are conveyed to the distribution device, the distribution device can uniformly distribute the biodegradable polymer microspheres in the separation component.

[0048] The working principle and beneficial effects of the above technical solution are as follows: In use, first prepare the required biodegradable polymer solution and inject it into the solution storage tank 9 through the solution inlet 10. Then, start the linear motor and drive the upper nozzle support 14 and lower nozzle support 15 up and down along the linear guide rail 2 via the fixed bracket 13 until the bottom of the nozzle 17 is 30cm above the annular electrode ring 4. At this time, apply a 30KW voltage to the nozzle 17 and a 25KW voltage to the annular electrode ring 4 through the electrostatic generator 7, thereby achieving coordinated and stable spraying of several nozzles 17 and controllable deposition of the biodegradable polymer solution. Subsequently, start the pressure pump 12 to discharge the biodegradable polymer solution in the solution storage tank 9 downwards through the syringe 16 (the pressure pump 12 is turned on for 20 seconds every minute), causing the biodegradable polymer solution to form scattered microspheres as it passes through the annular electrode ring 4 and fall into the collection tray 5 (the biodegradable polymer solution is driven by high-voltage electrostatics). The solution forms a Taylor cone jet at several nozzles 17. The electrostatic repulsion force experienced by the ejected charged droplets is greater than the surface tension, thus breaking them into smaller charged microspheres. For the specific working principle, please refer to the existing patent CN201310399452 (Two-stage electric field structure electrostatic jetting system and array and usage method). By applying voltage to the annular electrode ring 4, the dispersion range of the biodegradable polymer solution microspheres ejected from several nozzles 17 can be constrained, reducing raw material waste. Since the collection plate 5 is located directly below the annular electrode ring 4 and its overall shape is funnel-shaped, it contains a certain amount of buffer solution to buffer the high-speed flying biodegradable polymer solution microspheres. Subsequently, the buffer solution carries the biodegradable polymer solution microspheres through the through hole 501 and flows through the guide nozzle 21 into the collection component for filtration and separation to form biodegradable polymer spheres. After the biodegradable polymer spheres are transported to the distribution device, the distribution device can uniformly distribute the biodegradable polymer microspheres in the separation component.

[0049] It should be noted that the voltage applied by the electrostatic generator 7 to the annular electrode ring 4 and the nozzle 17 needs to be adjusted according to different biodegradable polymer solutions.

[0050] This invention can prepare polymers of different materials and sizes according to requirements, and can be widely used in the medical field. Through the separation components and their configuration, it realizes the automated separation and collection of biodegradable polymers, while ensuring that the entire process of preparation, separation and collection of medical biodegradable polymers is carried out in a clean environment.

[0051] Example 2

[0052] Based on Example 1, please refer to Figure 3The separation assembly includes: a first support column 22, a second support column 25, and a third support column 32. Two sets of first support columns 22 are fixedly connected to the bottom of the inner wall of the preparation chamber 1. A U-shaped block 23 is fixedly connected to the top of each set of first support columns 22, and a liquid accumulation tank 24 is placed inside the U-shaped block 23. Two sets of second support columns 25 are fixedly connected to the bottom of the inner wall of the preparation chamber 1, with the two sets of second support columns 25 located on either side of the two sets of first support columns 22. The top of each second support column 25 movably passes through the bottom of an adjusting sleeve 27, and the adjusting sleeve 27 is movably connected up and down along the outer wall of the second support column 25. The adjusting sleeve 27 and the second support column 32 can be connected by connecting bolts 26. 25 is fixed, and a buffer spring 28 is fixedly connected to the top of the adjusting sleeve 27. The mounting plate 29 is fixedly connected to the top of the buffer spring 28. Vibration dials 30 are fixedly connected to the left and right ends of the mounting plate 29, and a filter screen 31 is installed in the center of the mounting plate 29. Two sets of third support columns 32 are fixedly connected to the bottom of the inner wall of the preparation box 1, and the two sets of third support columns 32 are located on the two sets of second support columns 25 on both sides. A drive motor 33 is fixedly connected to the top of the third support column 32. A rotating ring 35 is fixedly sleeved on the output shaft of the drive motor 33. A ring of vibration dials 34 is provided on the outer wall of the rotating ring 35, and the vibration dials 34 abut against the vibration dials 30.

[0053] Preferably, a reflux pump is installed at the rear end of the inner wall of the preparation box 1 and at the same height as the liquid collection tank 24. The rear end of the liquid collection tank 24 is connected to the reflux nozzle 20 at the top of the collection tray 5 through the pump and a hose.

[0054] The working principle and beneficial effects of the above technical solution are as follows: In use, after lowering the adjusting sleeve 27 to allow the filter screen 31 to fully enter the collection tank 24, the adjusting sleeve 27 is fixed to the second support column 25 by the connecting bolt 26. When the buffer solution carrying biodegradable polymer solution microspheres flows into the filter screen 31 through the through hole 501 and the drainage nozzle 21, the drive motor 33 is started to drive the rotating ring 35 to rotate. At this time, several vibration plates 34 set on the outer ring of the rotating ring 35 continuously strike the vibration head 30, thereby causing the mounting plate 29 to vibrate under the action of the buffer spring 28, thus filtering the filter screen. The buffer solution carried on the surface of the biodegradable polymer solution microspheres in the mesh 31 is shaken into the collection tank 24, thereby achieving automated separation of the biodegradable polymer solution microspheres and the buffer solution. Since some of the biodegradable polymer solution microspheres will inevitably enter the collection tank 24 during the shaking process, the reflux pump can be started at this time. The liquid in the collection tank 24 is pumped into the collection tray 5 through the reflux nozzle 20, and then flows into the filter screen 31 through the through hole 501 and the guide nozzle 21 for multiple circulation filtration, thereby further reducing the waste of raw materials.

[0055] By adjusting the cooperation between the sleeve 27 and the second support column 25, the height of the filter screen 31 can be adjusted so that the filter screen 31 is completely inserted into the liquid collection tank 24, preventing the microspheres of the biodegradable polymer solution from spilling out during shaking. The setting of this separation component realizes the automated separation of biodegradable polymers and improves the preparation efficiency.

[0056] Example 3

[0057] Based on any one of Examples 1-2, please refer to Figure 4-6The material distribution device includes a screening box 36 and a secondary material distribution assembly 55. The screening box 36 is fixedly connected to the bottom of the inner wall of the preparation box 1. A microsphere hopper 38 is provided on the top of the screening box 36. A drying box 381 is installed inside the microsphere hopper 38. A second drive motor 39 is installed at the rear end of the inner wall of the screening box 36, and a feeding tray 40 is fixedly sleeved on the output shaft of the second drive motor 39. Several material troughs 42 are formed in the feeding tray 40 by several baffles 41 at intervals. A U-shaped cylinder 52 is fixedly connected to the bottom of the inner wall of the screening box 36. A support column 48 is fixedly connected to the center of the top of the U-shaped cylinder 52, and a primary material distribution box 43 is rotatably connected to the top of the support column 48. A primary screening box 43 is fixedly connected to the inner wall of the primary material distribution box 43. The screen 45 has a discharge port 44 and a discharge port 46 located on the outer wall of the primary material distribution box 43 with the primary screen 45 as the central axis. The double-headed cylinder 50 is fixedly connected to the inner wall of the horizontal section of the U-shaped cylinder 52, and the two output ends of the double-headed cylinder 50 are fixedly connected to the same piston head 51. The piston head 51 is movably connected to the inner wall of the horizontal section of the U-shaped cylinder 52, and the piston head 53 is movably connected to the inner wall of the vertical section of the U-shaped cylinder 52. The lower end of the first connecting rod 54 extends movably into the vertical section of the U-shaped cylinder 52 and is fixedly connected to the top of the piston head 53. The upper end of the first connecting rod 54 is rotatably connected to the bottom of the primary material distribution box 43. Two sets of secondary material distribution components 55 are symmetrically arranged on both sides of the U-shaped cylinder 52. Preferably, the secondary material distribution assembly 55 includes: a secondary material distribution box 56, with a microsphere inlet 57 at the top of the secondary material distribution box 56; a secondary screen 58, a first guide plate 59, a tertiary screen 60, a second guide plate 61, a quaternary screen 62, and a third guide plate 63 sequentially installed from top to bottom on the inner wall of the secondary material distribution box 56; the secondary screen 58, tertiary screen 60, and quaternary screen 62 are fixedly connected to the inner wall of the secondary material distribution box 56; the first guide plate 59, second guide plate 61, and third guide plate 63 are rotatably connected to the inner wall of the secondary material distribution box 56; a U-shaped tube 64 is connected through to the front outer wall of the secondary material distribution box 56, with one end of the U-shaped tube 64 located at the top of the secondary screen 58 and the other end located at the top of the tertiary screen 60; and a U-shaped tube 65 is connected through to the rear outer wall of the secondary material distribution box 56. One end of U-shaped tube 2 65 is set at the top of the third-stage screen 60, and the other end of U-shaped tube 2 65 is set at the top of the fourth-stage screen 62. The discharge port 3 66 and discharge port 5 68 are connected to the rear outer wall of the secondary distribution box 56. The discharge port 3 66 is set at the top of the first guide plate 59, and the discharge port 5 68 is set at the top of the third guide plate 63. The discharge port 4 67 and discharge port 69 are connected to the front outer wall of the secondary distribution box 56. The discharge port 4 67 is set at the top of the second guide plate 61, and the discharge port 69 is set at the top of the fourth-stage screen 62. The bottom of the first guide plate 59, the second guide plate 61, and the third guide plate 63 are all provided with tilt angle adjustment units. The angle adjustment unit includes a motor 70 and a cam 71. The motor 70 is fixedly installed on the inner wall of the secondary distribution box 56, and the output end of the motor 70 is fixedly sleeved with the cam 71.Preferably, the connecting pump 37 is installed at the bottom of the inner wall of the preparation chamber 1. The outlet of the connecting pump 37 is connected to the microsphere hopper 38 through the first connecting hose 47, and the inlet of the connecting pump 37 is connected to the filter screen 31 through the second connecting hose 49.

[0058] Preferably, outlet 366, outlet 467, outlet 568, and outlet 69 all penetrate through the screening box 36 and extend outside the preparation box 1, which facilitates the collection of microspheres of different sizes.

[0059] Preferably, the drying chamber 381 is connected to the first connecting hose 47. The drying chamber 381 is equipped with a heating wire and a micro fan. During the process of the biopolymer microspheres falling from the microsphere hopper 38 to the feed tray 40 through the drying chamber 381, the micro fan blows air onto the heating wire, so that hot air passes over the surface of the biopolymer microspheres, thereby drying the residual solvent on the surface of the biopolymer microspheres.

[0060] The working principle and beneficial effects of the above technical solution are as follows: When the connecting pump 37 is started, the biopolymer microspheres in the filter screen 31 are drawn from the first connecting hose 47 into the drying chamber 381 inside the microsphere hopper 38 through the second connecting hose 49 to remove residual solvent from the surface of the biopolymer microspheres. At this time, a number of biopolymer microspheres fall from the microsphere hopper 38 into the feeding tray 40. When the material trough 42 in the feeding tray 40 is connected to the microsphere hopper 38, the microspheres to be screened in the microsphere hopper 38 enter the material trough 42. Then, as the feeding tray 40 continues to rotate, interval quantitative feeding is achieved. The microspheres to be screened fall into the primary distribution box 43 for screening, preventing excessive pressure during screening caused by excessive feeding at one time. When microspheres clog the primary screen 45, the double-headed cylinder 50 starts, driving the two sets of piston heads 51 at both ends to slide back and forth. Since the space between piston head 51 and piston head 53 is filled with inert gas, the two sets of first connecting rods 54 will move up and down back and forth, causing the distribution box 43 to rotate around the top of the support column 48. While the distribution box 43 is rotating, microspheres larger than the aperture of the primary screen 45 will flow through the discharge port 44 to the secondary distribution component 55 on the left, and microspheres smaller than the aperture of the primary screen 45 will fall to the bottom of the primary distribution box 43 and flow through the discharge port 46 to the secondary distribution component 55 on the right. At this time, the microspheres are initially separated.

[0061] Subsequently, the microspheres, after initial separation, fall into the secondary distribution box 56 through the microsphere inlet 2 57. The secondary screen 58, tertiary screen 60, and quaternary screen 62 are three different screens with different apertures. Taking the secondary screen 58 as an example, microspheres that conform to the aperture of the secondary screen 58 will fall onto the first guide plate 59 and be discharged and collected through the discharge port 3 66 along the first guide plate 59. Microspheres that do not conform to the aperture of the secondary screen 58 will flow through the U-shaped tube 1 64 to the next layer of the tertiary screen 60 for screening, and so on, thus obtaining three different sizes of microspheres. The microspheres that are finally discharged from the discharge port 69 are unqualified products and need to be collected and processed. In this way, various sizes of microspheres can be obtained, collected, and classified, so that they can be used and sold according to actual needs.

[0062] It should be noted that the screen diameters in the two secondary sorting components 55 on the left and right sides are different. The left side is used to screen and classify microspheres with larger diameters, while the right side is used to screen and classify microspheres with smaller diameters. Since the diameter of the microspheres varies depending on the requirements, the diameter of the microspheres for each quality is not specified here. The screens with different pore sizes in the secondary sorting components 55 can be replaced according to actual needs to achieve this purpose.

[0063] By using a dispensing device, the biodegradable polymer microspheres in the separation component can be uniformly dispensed, resulting in microspheres of various sizes. These microspheres can then be collected and classified for use and sale according to actual needs.

[0064] Example 4

[0065] Based on any one of Examples 1-3, it also includes:

[0066] Several hydraulic sensors are respectively installed at several nozzles 17 to detect the pressure of the solution sprayed from the nozzles 17;

[0067] Several flow rate sensors: respectively installed at several nozzles 17, used to detect the flow rate of the solution passing through the nozzles 17;

[0068] Timer: The timer is set on the upper nozzle bracket 14 and is used to detect the spraying duration of the nozzle 17;

[0069] Alarm: The alarm is installed on the outer surface of the preparation box 1;

[0070] Controller: The controller is located on the outer surface of the preparation chamber 1, and is electrically connected to several hydraulic sensors, several flow rate sensors, a timer, and an alarm.

[0071] The controller controls the alarm based on several hydraulic sensors, several flow rate sensors, and a timer, including the following steps:

[0072] Step 1: The controller calculates the spray stability index of nozzle 17 based on the detection values ​​of several hydraulic sensors, several flow rate sensors, timers, and formula (1):

[0073]

[0074] Where X is the spray stability index of nozzle 17, P1 is the average spray pressure of nozzle 17 detected by several hydraulic sensors, P2 is the maximum spray pressure of nozzle 17 detected by several hydraulic sensors, V1 is the average spray velocity at nozzle 17 detected by several flow rate sensors, R1 is the radius of the spray hole of nozzle 17, S1 is the effective spray area of ​​nozzle 17, T is the spray time of nozzle 17 detected by the timer, e is the natural constant with a value of 2.72, and ω is the wear coefficient of several nozzles 17 (with a value greater than 0 and less than 1, related to the usage time of several nozzles 17 and the influence of the usage environment on several nozzles 17). K is the stability coefficient of several nozzles 17 (with a value greater than 0 and less than 1, set to take into account the stability factors of the internal structure installation of several nozzles 17); K is the product of the accuracy of several hydraulic sensors and several flow rate sensors (with a value greater than 0 and less than 1, set to take into account the accuracy factors of the sensors themselves).

[0075] Step 2: The controller compares the spray stability index of nozzle 17 with the preset spray stability index of nozzle 17. When the spray stability index of nozzle 17 is less than the preset spray stability index of nozzle 17 (0.85), the controller controls the alarm to issue an alarm prompt.

[0076] The working principle and beneficial effects of the above technical solution are as follows: When the nozzle 17 is used multiple times, the hydraulic sensor, flow sensor and timer are used to detect the solution pressure and solution velocity during the working process of the nozzle 17. The controller uses formula (1) to obtain the spray stability index of the nozzle 17. If the spray stability index of the nozzle 17 is less than the preset spray stability index (0.85) of the nozzle 17, the controller controls the alarm to issue an alarm prompt, reminding the operator to check the nozzle 17 to prevent the nozzle 17 from breaking or being damaged, thereby improving the safety and reliability of the device.

[0077] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A medical biodegradable polymer preparation device, comprising: The preparation of the box body (1) is characterized in that, Two sets of linear guide rails (2) are symmetrically installed inside the preparation box (1). Between the two sets of linear guide rails (2), a biodegradable polymer solution nozzle (3), a ring electrode ring (4) and a collection plate (5) are arranged from top to bottom. A separation component is installed at the bottom of the preparation box (1) and below the collection plate (5). A dispensing device is provided at the bottom of the preparation box (1) and to the left of the separation component. The dispensing device can uniformly dispense the biodegradable polymer microspheres in the separation component. The separation assembly includes: a first support column (22), a second support column (25), and a third support column (32). Two sets of first support columns (22) are fixedly connected to the bottom of the inner wall of the preparation box (1). A U-shaped block (23) is fixedly connected to the top of the two sets of first support columns (22). A liquid accumulation tank (24) is placed inside the U-shaped block (23). Two sets of second support columns (25) are fixedly connected to the bottom of the inner wall of the preparation box (1). The two sets of second support columns (25) are located on both sides of the two sets of first support columns (22). The top of the second support column (25) moves through the bottom of the adjusting sleeve (27). The adjusting sleeve (27) moves up and down along the outer wall of the second support column (25). The adjusting sleeve (27) and the second support column (25) can be connected by connecting bolts (26). The top of the adjusting sleeve (27) is fixedly connected to a buffer spring (28), the mounting plate (29) is fixedly connected to the top of the buffer spring (28), the left and right ends of the mounting plate (29) are respectively fixedly connected to a vibration dial (30), and a filter screen (31) is installed in the center of the mounting plate (29). Two sets of third support columns (32) are fixedly connected to the bottom of the inner wall of the preparation box (1), and the two sets of third support columns (32) are located on the two sets of second support columns (25) on both sides. The top of the third support column (32) is fixedly connected to a drive motor (33), and a rotating ring (35) is fixedly sleeved on the output shaft of the drive motor (33). A ring of vibration dial (34) is provided on the outer wall of the rotating ring (35), and the vibration dial (34) abuts against the vibration dial (30).

2. The medical biodegradable polymer preparation equipment according to claim 1, characterized in that: The electrostatic generator (7) is fixedly connected to the rear end of the inner wall of the preparation box (1). The biodegradable polymer solution nozzle (3), the annular electrode ring (4) and the collection tray (5) are electrically connected to the electrostatic generator (7) through several wires (6). The biodegradable polymer solution nozzle (3) is connected to the solution storage tank (9) through several hoses (8). The annular electrode ring (4) is fixedly connected to the outer wall of the rear end of the linear guide rail (2) through the first fixing rod (18).

3. The medical biodegradable polymer preparation equipment according to claim 2, characterized in that: The solution storage tank (9) is fixedly connected to the inner wall of the left side of the preparation box (1). The outer wall of the preparation box (1) is provided with a solution inlet (10), and the solution storage tank (9) is connected to the solution inlet (10). The side of the solution storage tank (9) away from the solution inlet (10) is connected to the input end of the pressure pump (12) through a connecting pipe (11). The pressure pump (12) is fixedly connected to the top of the inner wall of the solution storage tank (9), and the output end of the pressure pump (12) is connected to the biodegradable polymer solution nozzle (3) through several hoses (8).

4. The medical biodegradable polymer preparation equipment according to claim 1, characterized in that: Two sets of linear guide rails (2) are fixedly connected to the rear end of the inner wall of the preparation box (1). Two sets of fixed brackets (13) are symmetrically arranged on the side of the two sets of linear guide rails (2) that are close to each other. The two sets of fixed brackets (13) slide up and down along the two sets of linear guide rails (2) through a linear motor. The linear motor is installed inside the linear guide rails (2).

5. The medical biodegradable polymer preparation equipment according to claim 3, characterized in that: The biodegradable polymer solution nozzle (3) includes: an upper nozzle support (14) and a lower nozzle support (15). The upper nozzle support (14) is fixedly connected between two sets of fixed supports (13). The lower nozzle support (15) is fixedly connected to the lower end of the upper nozzle support (14). Several syringes (16) are installed in a ring on the upper nozzle support (14). The lower ends of the syringes (16) are fixedly inserted through the upper nozzle support (14) and extend to the bottom of the lower nozzle support (15). Several nozzles (17) are provided at the ends of the syringes (16) that extend out of the lower nozzle support (15).

6. The medical biodegradable polymer preparation equipment according to claim 3, characterized in that: Two sets of linear guide rails (2) are fixedly connected to two sets of fixing blocks (19) at the bottom respectively. The collection plate (5) is fixedly connected to the two sets of fixing blocks (19). Several sets of return nozzles (20) are fixedly arranged around the top of the collection plate (5). A through hole (501) is opened in the center of the collection plate (5). The flow nozzle (21) is installed at the bottom center of the collection plate (5) and communicates with the through hole (501). The overall shape of the collection plate (5) is funnel-shaped.

7. The medical biodegradable polymer preparation equipment according to claim 1, characterized in that: The material distribution device includes: a screening box (36) and a secondary material distribution component (55). The screening box (36) is fixedly connected to the bottom of the inner wall of the preparation box (1). A microsphere hopper (38) is provided on the top of the screening box (36). A drying box (381) is installed inside the microsphere hopper (38). A second drive motor (39) is installed at the rear end of the inner wall of the screening box (36). A feeding tray (40) is fixedly sleeved on the output shaft of the second drive motor (39). Several material troughs (42) are formed in the feeding tray (40) by several baffles (41) at intervals. A U-shaped cylinder (52) is fixedly connected to the bottom of the inner wall of the screening box (36). A support column (48) is fixedly connected to the center of the top of the U-shaped cylinder (52). A primary material distribution box (43) is rotatably connected to the top of the support column (48). A first-stage material distribution box (43) is fixedly connected to the inner wall of the primary material distribution box (43). A primary screen (45) is provided with a discharge port 1 (44) and a discharge port 2 (46) on the outer wall of the primary distribution box (43) with the primary screen (45) as the central axis. A double-headed cylinder (50) is fixedly connected to the inner wall of the horizontal section of the U-shaped cylinder (52), and the two output ends of the double-headed cylinder (50) are fixedly connected with the same piston head 1 (51). The piston head 1 (51) is movably connected to the inner wall of the horizontal section of the U-shaped cylinder (52), and the piston head 2 (53) is movably connected to the inner wall of the vertical section of the U-shaped cylinder (52). The lower end of the first connecting rod (54) extends movably into the vertical section of the U-shaped cylinder (52) and is fixedly connected to the top of the piston head 2 (53). The upper end of the first connecting rod (54) is rotatably connected to the bottom of the primary distribution box (43). Two sets of secondary distribution components (55) are symmetrically provided on both sides of the U-shaped cylinder (52).

8. The medical biodegradable polymer preparation equipment according to claim 7, characterized in that: The secondary material distribution assembly (55) includes: a secondary material distribution box (56), the top of which has a microsphere inlet (57), and the inner wall of the secondary material distribution box (56) is sequentially equipped with a secondary screen (58), a first guide plate (59), a tertiary screen (60), a second guide plate (61), a quaternary screen (62), and a third guide plate (63) from top to bottom. The secondary screen (58), tertiary screen (60), and quaternary screen (62) are connected to the secondary material distribution box (56). The inner wall is fixedly connected, and the first guide plate (59), the second guide plate (61), and the third guide plate (63) are rotatably connected to the inner wall of the secondary distribution box (56). U-shaped tube one (64) is connected through to the front outer wall of the secondary distribution box (56), and one end of U-shaped tube one (64) is set on the top of the secondary screen (58), and the other end of U-shaped tube one (64) is set on the top of the tertiary screen (60). U-shaped tube two (65) is connected through to the rear outer wall of the secondary distribution box (56), and U-shaped tube two (65) is connected through to the rear outer wall of the secondary distribution box (56). One end of pipe two (65) is set at the top of the third-stage screen (60), and the other end of U-shaped pipe two (65) is set at the top of the fourth-stage screen (62). The discharge port three (66) and the discharge port five (68) are connected to the rear outer wall of the secondary distribution box (56). The discharge port three (66) is set at the top of the first guide plate (59), the discharge port five (68) is set at the top of the third guide plate (63), and the discharge port four (67) and the discharge port six (69) are connected to the secondary distribution box (56). The front outer wall, and the discharge port four (67) is set on the top of the second guide plate (61), and the discharge port six (69) is set on the top of the fourth-stage screen (62). The bottom of the first guide plate (59), the second guide plate (61) and the third guide plate (63) are all provided with tilt angle adjustment units. The angle adjustment unit includes a motor (70) and a cam (71). The motor (70) is fixedly installed on the inner wall of the secondary distribution box (56), and the output end of the motor (70) is fixedly sleeved with a cam (71).

9. A process for preparing a medical biodegradable polymer, used to control the preparation of the medical biodegradable polymer using the equipment described in any one of claims 1-8, characterized in that, The preparation process includes: Step 1: Prepare a biodegradable polymer solution and inject the biodegradable polymer solution into the solution storage tank (9) through the solution inlet (10); Step 2: The linear motor is started and drives the biodegradable polymer solution nozzle (3) to move up and down along the linear guide rail (2) through the fixed bracket (13) until the height of the biodegradable polymer solution nozzle (3) from the annular electrode ring (4) is 30cm. Step 3: Apply voltage to the nozzle (17) and the annular electrode ring (4) through the electrostatic generator (7); Step 4: Start the pressure pump (12) to discharge the biodegradable polymer solution in the solution storage tank (9) through the syringe (16), so that the biodegradable polymer solution forms scattered microspheres after passing through the ring electrode ring (4) and falls into the collection tray (5); Step 5: The biodegradable polymer solution in the collection tray (5) is scattered and transported to the separation component through the guide nozzle (21) for filtration and separation to form biodegradable polymer balls; Step 6: After the biodegradable polymer spheres are conveyed to the distribution device, the distribution device can uniformly distribute the biodegradable polymer microspheres in the separation component.

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