Facial Mask Compositions and Methods

Abstract

A facial mask for caring for keratin materials, comprising: (1) at least one hydrogel layer, (2) at least one fiber-based layer, wherein at least one fiber-based layer is a layer closer to the keratin material than all the hydrogel layers present in the facial mask. A method for preparing the facial mask and its uses are also provided.

Description

Field of the Invention

[0001] The present invention relates to a facial mask composition for topical application comprising a water-insoluble substrate, said substrate comprising a composition that provides a functional benefit to the skin. In addition, the present invention relates to a corresponding non-therapeutic method of using the same facial mask. Background of the Invention

[0003] Sheets formed from a substrate sheet (such as a nonwoven fabric sheet) impregnated with a lotion (lorion) or the like have been used for the cosmetic treatment of the skin, particularly the face. Such facial masks for cosmetic treatment are for example disclosed in patent application WO 02 / 062132, which provides the beneficial effect of significantly changing the skin tone to the skin.

[0004] It is also known to use active substances in cosmetics for treating or caring for the skin, such as hydration, whitening, anti-aging, pore reduction, refreshing, smoothing, softening, etc. Among them, skin conditioning effects (such as hydration) are always of interest to consumers worldwide. A cosmetic facial mask impregnated with a lotion containing a skin conditioner is suitable for application to the skin to provide in particular a skin hydration effect. To meet this demand, various facial masks have been developed.

[0005] In addition to the active agent, the support of the facial mask is an important part. Currently, the general products of facial masks on the market are divided into two types: one uses a non-woven fabric sheet, and the other uses a gel sheet.

[0006] The disadvantage of a facial mask made of a fibrous sheet is that it can only hold or load a limited amount of a functional liquid containing one or more active agents, and one or more active agents contained in the fibrous sheet are directly exposed to the air. Therefore, the application time of a facial mask made of a fibrous sheet is limited to a short time because one or more active agents contained in the fibrous sheet volatilize or dry out in a short time. Such a facial mask made of a fibrous sheet cannot provide a continuous effect on the skin. In addition, a facial mask made of a fibrous sheet has sufficient moisture at the beginning of use, which causes the skin to absorb too much water; subsequently, when the facial mask made of a fibrous sheet dries, the facial mask made of a fibrous sheet absorbs moisture from the skin in the reverse direction, which will make the skin uncomfortable, such as tight.

[0007] The disadvantage of a facial mask made of a gel sheet is that since the gel sheet is usually used as a support material, it must be used with a liquid preparation; otherwise, it cannot deliver cosmetic efficacy to the skin. In other words, a facial mask made of a gel sheet cannot deliver active substances to the skin well even when filled with a functional liquid containing one or more active agents.

[0008] However, the face masks available to date still have room for improvement, particularly in terms of the long-term active effects of using a large amount of active agents.

[0009] Based on the above, there is a need for a face mask that can effectively deliver skin-conditioning active substances to the skin in large amounts of active substances during long-term application. In particular, there is a need for the following face mask, which has a high active substance loading (e.g., providing good skin-conditioning benefits to the skin, particularly moisturizing, refreshing, smooth and soft, etc.), while having excellent delivery ability when applied to the skin.

[0010] Disclosure of the Invention

[0011] An object of the invention is to provide a novel solid hydrogel sheet face mask, which has a high active substance loading and excellent delivery ability. This face mask effectively delivers skin-conditioning active substances to the skin in large amounts of active substances during long-term application.

[0012] The above object of the present invention can be achieved by a face mask that at least comprises:

[0013] (1) one or more fiber-based layers as defined in the present invention;

[0014] (2) one or more hydrogel layers as defined in the present invention, which are in contact with the fiber-based layer and optionally contain one or more active agents;

[0015] wherein at least one fiber-based layer is a layer closer to the keratin material than any hydrogel layer present in the face mask after application.

[0016] Another aspect of the present invention provides a method for preparing a face mask, comprising the following steps:

[0017] - providing a fiber-based layer;

[0018] - providing a hydrogel layer containing one or more active agents,

[0019] - coating the fiber-based layer on the hydrogel layer.

[0020] Another aspect of the present invention provides a skin wound dressing that at least comprises:

[0021] (1) one or more fiber-based layers as defined in the present invention;

[0022] (2) one or more hydrogel layers as defined in the present invention, which are in contact with the fiber-based layer and optionally contain one or more active agents;

[0023] wherein at least one fiber-based layer is a layer closer to the keratin material than all the hydrogel layers present.

[0024] These and other features, aspects, and advantages of the present invention will be better understood by reading the following description and claims.

[0025] Preferably, the "keratin material" according to the present invention is the skin. "Skin" refers to all body skin, including the scalp. Also preferably, the keratin material is the face or neck, especially the face.

[0026] "Topical application" means applying or spreading the composition onto the surface of a keratin material, such as the skin. Detailed Description of the Invention

[0028] Hereinafter and unless otherwise indicated, the boundaries of numerical ranges are included within the range, especially in the expressions "from... to..." and "between... and...".

[0029] The terms "a" and "the" are understood to include the plural as well as the singular.

[0030] The term "at least one" means "one or more", and vice versa, and thus includes both individual components and mixtures / combinations.

[0031] When the term "about" refers to a value, it particularly means that the measurement result can be rounded to that value using the standard convention of numerical rounding. For example, "about 1.5" is from 1.45 to 1.54. In cases where the above meaning needs to be given, or in the absence of the term, all values listed herein can be modified by the term "about", whether or not the term "about" is explicitly listed (or not) together with any specific value in the specification.

[0032] According to the present invention, the facial mask comprises a facial mask for caring for a keratin material, comprising at least:

[0033] (1) one or more fiber-based layers as defined in the present invention;

[0034] (2) one or more hydrogel layers as defined in the present invention, which are in contact with the fiber-based layer and optionally contain one or more active agents;

[0035] wherein at least one fiber-based layer is a layer closer to the keratin material than all the hydrogel layers present in the facial mask.

[0036] Hydrogel Layer

[0037] The hydrogel layer used in the present facial mask is an insoluble solid hydrogel layer, to which an active substance is optionally added. Generally, all types of insoluble solid hydrogel layers containing at least one water-soluble alkali metal salt acceptable in the beauty field can be used in the present invention.

[0038] The hydrogel layer is prepared from the following materials which contain water, a gel-forming composition, and at least one water-soluble alkali metal salt.

[0039] Gel-Forming Composition

[0040] According to one aspect, the gel-forming composition according to the present invention contains at least one hydrophilic thickener (also known as an aqueous-phase thickening polymer).

[0041] There are no special restrictions on the hydrophilic thickener. For example, the hydrophilic thickener can be selected from the following compounds:

[0042] (i) Homopolymers or copolymers of acrylic acid or methacrylic acid or their salts and esters

[0043] Particularly mentionable examples include products sold by Allied Colloid under the names Versicol F or Versicol K, products sold by Ciba-Geigy under the name Ultrahold 8, products sold by BASF under the name Cosmedia SP, products sold by Lucas Meyer Cosmetics under the name Lecigel (a mixture of sodium acrylate copolymer / lecithin); polyacrylic acid of the Synthalen K type, and polyacrylates, especially the sodium salt (corresponding to the INCI name sodium acrylate copolymer), and more particularly crosslinked sodium polyacrylate sold under the name Luvigel EM (corresponding to the INCI name sodium acrylate copolymer (and) caprylic / capric triglyceride).

[0044] Also mentionable are polyacrylic acid / acrylic acid alkyl ester copolymers, preferably modified or unmodified carboxyvinyl polymers, most particularly acrylate / acrylic acid C10-C30 alkyl ester copolymers (INCI name: acrylate / acrylic acid C10-30 alkyl ester crosslinked polymer), such as products sold by Lubrizol under the trade names Pemulen TR1, Pemulen TR2, Carbopol 1382, Carbopol EDT 2020, and even more preferably Pemulen TR-2; copolymers of methacrylic acid, methyl methacrylate, methylstyrene isocyanate, and PEG-40 behenate (INCI name: polyacrylate-3) (Viscophobe DB 1000 sold by Dow).

[0045] (ii) Copolymers of acrylic acid and acrylamide

[0046] Those in the form of their sodium salts sold by Hercules under the name Reten, sodium polymethacrylate sold by Vanderbilt under the name Darvan No. 7, and the sodium salts of polyhydroxycarboxylic acids sold by Henkel under the name Hydagen F may be mentioned.

[0047] (iii) Homopolymers and copolymers based on acrylamidopropanesulfonic acid

[0048] For example, the following may be mentioned:

[0049] - Polyacrylamidomethylpropanesulfonic acid partially neutralized with ammonia and highly cross-linked, such as, in particular, the product Hostacerin AMPS sold by Clariant.

[0050] - Copolymers of acrylamidopropanesulfonic acid / acrylamide, such as, in particular, those of the Sepigel or Simulgel type sold by SEPPIC.

[0051] - Polyoxyethylenated acrylamidopropanesulfonic acid / alkyl methacrylate copolymers (cross-linked or non-cross-linked) of the following types, such as, in particular, Aristoflex HMS and Aristoflex TAC sold by Clariant.

[0052] - Copolymers of acrylamidomethylpropanesulfonic acid and hydroxyethyl acrylate, such as acrylamidomethylpropanesulfonic acid / hydroxyethyl acrylate copolymers, in particular those used in commercial products such as Simulgel NS sold by SEPPIC, or acrylamidomethylpropanesulfonic acid / hydroxyethyl acrylate copolymers, in particular those used in commercial products such as Sepinov EMT10 sold by SEPPIC (INCI name: hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer);

[0053] - Copolymers of acrylamidomethylpropanesulfonic acid and vinylpyrrolidone, such as the product Aristoflex AVC sold by Clariant (ammonium acryloyldimethyltaurate / VP copolymer in water); and

[0054] - Mixtures thereof.

[0055] Alternatively, the hydrophilic thickener may be selected from:

[0056] - Anionic, cationic, amphoteric or non-ionic chitin or chitosan polymers;

[0057] - Cellulose polymers, especially (C1-C3) hydroxyalkyl celluloses, selected from hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl cellulose, ethyl hydroxyethyl cellulose; carboxymethyl cellulose and quaternized derivatives of cellulose;

[0058] - Vinyl polymers, such as polyvinylpyrrolidone, copolymers of methyl vinyl ether and maleic anhydride, copolymers of vinyl acetate and crotonic acid, copolymers of vinylpyrrolidone and vinyl acetate; copolymers of vinylpyrrolidone and caprolactam; polyvinyl alcohol,

[0059] - Optionally modified polymers of natural origin, such as galactomannans and their derivatives, for example carrageenan, konjac gum, gellan gum, locust bean gum, fenugreek gum, sterculia gum, tragacanth gum, gum arabic, acacia gum, guar gum and its derivatives (carboxymethyl guar gum, hydroxypropyl guar gum, hydroxypropyl guar gum modified with sodium methyl carboxylate groups (Jaguar XC97-1, Rhodia)) xanthan gum and its derivatives;

[0060] - Alginates and carrageenans, for example carrageenans of the μ, κ, v, ι or λθ types, and mixtures in all proportions, preferably of the κ type;

[0061] - Mucopolysaccharides such as hyaluronic acid;

[0062] - And mixtures thereof.

[0063] According to some embodiments, the thickening polymer is selected from xanthan gum, carrageenan, konjac gum, guar gum, hydroxypropyl gum, locust bean gum and carboxymethyl cellulose.

[0064] According to some embodiments, the composition according to the invention comprises carrageenan and konjac gum as hydrophilic gums.

[0065] According to some embodiments, the composition according to the invention comprises xanthan gum and konjac gum as hydrophilic gums.

[0066] According to some embodiments, the composition according to the invention comprises hydroxypropyl guar gum as a hydrophilic gum.

[0067] In order to increase the gel strength, the composition according to the invention may further comprise a crosslinking agent.

[0068] As an example of a crosslinking agent, sodium borate may be mentioned.

[0069] According to one embodiment, the composition according to the invention comprises hydroxypropyl guar gum as a hydrophilic gum and comprises borax as a crosslinking agent.

[0070] Under the teachings of this specification, those skilled in the art can adjust the amount and / or type of thickener and / or crosslinking agent to obtain the composition according to the present invention.

[0071] In some preferred embodiments, the composition according to the present invention comprises carrageenan and konjac gum as hydrophilic gums, and the total amount of carrageenan and konjac gum is 0.2% to 10% by weight based on the total weight of the composition.

[0072] In some preferred embodiments, the composition according to the present invention comprises xanthan gum and konjac gum as hydrophilic gums, and the total amount of xanthan gum and konjac gum is 0.5% to 10% by weight based on the total weight of the composition.

[0073] In some preferred embodiments, the composition according to the present invention comprises hydroxypropyl guar gum as a hydrophilic gum, and the amount of hydroxypropyl guar gum is 0.5% to 10% by weight based on the total weight of the composition.

[0074] In some preferred embodiments, the composition according to the present invention comprises hydroxypropyl guar gum as a hydrophilic gum and borax as a crosslinking agent, and the amount of hydroxypropyl guar gum is 0.5% to 10% by weight based on the total weight of the composition.

[0075] As commercial products of carrageenan, mention may be made of those sold by Cargill under the names Satiagum UTC 30 Carrageenan lamda Cargill, Satiagum UTC 10 Carrageenan lamda and Cargill SATIAGEL TM UHD 300, those sold by BLG under the name CARRAGEENAN BLK120 and those sold by Greenfresh under the name KA120LMO.

[0076] As commercial products of konjac gum, mention may be made of the konjac gum sold by XieLi under the name KONJAC GEL CKAA1220 and the konjac gum sold by BLG under the name KONJAC FLOUR HWG1002.

[0077] As commercial products of xanthan gum, mention may be made of the xanthan gum sold by CP KELCO under the names KELTROL CG or KELTROL CG-T; and the xanthan gum sold by PMC OUVRIE under the name RHODICARE XC.

[0078] As a commercial product of hydroxypropyl guar gum, mention may be made of hydroxypropyl guar gum sold by RHODIA (SOLVAY) under the name JAGUAR HP105 SGI.

[0079] Water-Soluble Alkali Metal Salt

[0080] In one embodiment of the present invention, the water-soluble alkali metal salts that can be used in the present invention include all kinds of alkali metals (such as Li, Na, K, etc.) that form soluble salts acceptable in the field of cosmetics (chlorides, nitrates, etc.).

[0081] In one embodiment of the present invention, the water-soluble alkali metal salts are selected from water-soluble alkali metal salts of one or more inorganic acids and / or one or more organic acids. The water-soluble alkali metal salts of inorganic acids are selected from, for example, alkali metal chlorides, alkali metal nitrates, alkali metal citrates, alkali metal sulfates, alkali metal carbonates, alkali metal bicarbonates, alkali metal phosphates, alkali metal acetates, etc. The water-soluble alkali metal salts of organic acids are selected from, for example, alkali metal salts of EDTA, alkali metal salts of carboxylic acids, alkali metal salts of lactic acid, alkali metal salts of acetic acid, alkali metal salts of formic acid, alkali metal salts of uric acid, alkali metal salts of malic acid, alkali metal salts of tartaric acid, etc.

[0082] In one embodiment of the present invention, the alkali metal is selected from Li, Na and K.

[0083] In one embodiment of the present invention, the water-soluble alkali metal salts are selected from disodium ethylenediaminetetraacetate (i.e., EDTA disodium salt) and sodium citrate.

[0084] In one embodiment of the present invention, relative to the weight of the hydrogel layer, the amount of the water-soluble alkali metal salt is 0.01 to 15% by weight, preferably 0.05 to 12% by weight, or 0.1 to 10% by weight, or even 1 to 8% by weight.

[0085] In one embodiment of the present invention, the weight of the hydrogel layer is 400 g / m 2 to 1600 g / m 2 .

[0086] In addition to water, the above-mentioned water-soluble alkali metal salts and hydrophilic thickeners, the hydrogel layer of the present invention may further contain additional components.

[0087] Additional Components

[0088] As additional components, mention may be made of water-miscible or at least partially water-miscible compounds for improving the hydration feeling, such as C2 to C8 lower polyols or monohydric alcohols, such as ethanol and isopropanol.

[0089] The term "polyol" is to be understood as meaning any organic molecule containing at least two free hydroxyl groups. Examples of polyols include diols such as pentanediol, butanediol, propanediol and isopentanediol, octylene glycol, glycerol (i.e., glycerin) and polyethylene glycol.

[0090] As additional components, sebum-absorbing components may also be mentioned.

[0091] The sebum-absorbing component may be an inorganic or organic sebum-absorbing particle. The particles of one or more inorganic compounds used in the hydrogel layer may have different shapes, such as spheres, solid or hollow, debris, needles or flakes, and preferably they are substantially spherical.

[0092] More specifically, the sebum-absorbing particles may be selected from:

[0093] - silica powder,

[0094] - polyamide powder,

[0095] - powders of acrylic polymers, especially powders of: polymethyl methacrylate, poly(methyl methacrylate / ethylene glycol dimethacrylate), poly(allyl methacrylate / ethylene glycol dimethacrylate), ethylene glycol dimethacrylate / lauryl methacrylate copolymer,

[0096] - powders of silicone elastomers, especially obtained by polymerization of an organopolysiloxane containing at least two hydrogen atoms each bonded to a silicon atom and an organopolysiloxane containing at least two ethylenically unsaturated groups (especially two vinyl groups) in the presence of a platinum catalyst,

[0097] - polylactic acid,

[0098] - cellulose,

[0099] - talc,

[0100] - carbon black

[0101] - perlite,

[0102] - clay, and

[0103] - mixtures thereof.

[0104] The sebum-absorbing particles may be powders coated with a hydrophobic treatment agent.

[0105] The hydrophobic treatment agent may be selected from: fatty acids such as stearic acid; metal soaps such as aluminum dimyristate, aluminum salt of hydrogenated tallow glutamate; amino acids; N-acyl amino acids or their salts; lecithin, titanium isopropyl triisostearate, wax, and mixtures thereof.

[0106] The N-acyl amino acid may contain an acyl group having 8 to 22 carbon atoms, such as 2-ethylhexanoyl, hexanoyl, lauroyl, myristoyl, palmitoyl, stearoyl or cocoyl. The salts of these compounds may be aluminum, magnesium, calcium, zirconium, zinc, sodium or potassium salts. The amino acid may be, for example, lysine, glutamic acid or alanine.

[0107] As a non-limiting illustration of the sebum-absorbing particles according to the invention, the following particles may be mentioned in particular.

[0108] The silica that can be used may be natural and untreated. Thus, mention may be made of the silica supplied by Hoffmann Mineral under the names Sillitin N85, Sillitin N87, Sillitin N82, Sillitin V85 and Sillitin V88.

[0109] They may be calcined silica.

[0110] Calcined silica can be obtained by high-temperature hydrolysis of volatile silicon compounds in a hydrogen-oxygen flame to produce finely divided silica. This process makes it possible in particular to obtain hydrophilic silica containing a large number of silanol groups on its surface. The surface of the silica can be chemically modified via a chemical reaction that results in a reduction in the number of silanol groups. In particular, the silanol groups can be replaced with hydrophobic groups; hydrophobic silica is then obtained.

[0111] The hydrophobic group can be:

[0112] -(a) Trimethylsilyloxy, which is obtained in particular by treating calcined silica in the presence of hexamethyldisilazane. The silica thus treated is called "silylated silica" according to CTFA (6th edition, 1995);

[0113] -(b) Dimethylsilyloxy or polydimethylsiloxane groups, which are obtained in particular by treating calcined silica in the presence of polydimethylsiloxane or dimethyldichlorosilane. The silica thus treated is called "dimethylsilylated silica" according to CTFA (6th edition, 1995).

[0114] Silica powders that may be mentioned more particularly include:

[0115] - Porous silica microspheres, supplied by Miyoshi under the name Silica Microspheres SB-700, and by Asahi Glass under the names H51, H33;

[0116] - Amorphous silica microspheres coated with polydimethylsiloxane, supplied by Asahi Glass under the names SA H33 and SA H53 for sale;

[0117] - Precipitated silica microspheres, such as those coated with an inorganic wax such as polyethylene and sold in particular by Evonik Degussa under the name Acematt OK 412;

[0118] - Silylated silica, such as DC VM - 2270 sold by DOW CORNING and KTL 10 sold by TOKUYAMA.

[0119] Acrylic polymer powders that may be mentioned include:

[0120] Acrylate copolymer powders, such as EXPANCEL 551 sold by AKZO NOBEL;

[0121] Lauryl methacrylate / ethylene glycol dimethacrylate crosslinked polymer powders, such as Polytrap 6603 sold by AMCOLHEALTH&BEAUTY SOLUTIONS;

[0122] Polymethyl methacrylate, such as SEPIMAT H10 sold by MATSUMOTO YUSHI - SEIYAKU.

[0123] The nylon powder that may be mentioned is the nylon powder sold by Atochem under the name 4000.

[0124] Silicone elastomers are in particular partially or fully crosslinked elastomeric organopolysiloxanes with a three - dimensional structure, such as those sold by SHIN - ETSU under the name and by DOW - CORNING under Trefil E - and Trefil E - by GRANT INDUSTRIES under Gransil SR - SR SR - SR 5CYC SR DMF 10 and SR DC 556 by GENERALELECTRIC under SF and JK those sold.

[0125] Silicone elastomer powders that may be mentioned include those sold by Dow Corning under the names “ Powder E - 505C” and “ The powder sold as "Powder E-506C".

[0126] As silicone powders, mention may be made of the gum microspheres of crosslinked polydimethylsiloxane coated with a silsesquioxane resin, in particular those sold by Shin Etsu under the name KSP100; silicone resin powders in the form of rugby balls, such as in particular the product sold by TAKEMOTO under the name NLK-602.

[0127] As polylactic acid, mention may be made of TORAYPEARL PLA sold by TORAY INDUSTRIES, Inc.

[0128] As cellulose powder, mention may be made of CELLULOBEADS USF sold by DAITO KASEI Co., Ltd.

[0129] Perlite is a natural glass of volcanic origin, with a shiny light grey or black colour, caused by the rapid cooling of lava and provided in the form of small particles similar to pearls.

[0130] The perlite particles used according to the invention can in particular be commercially obtained under the trade names Perlite P1430, Perlite P2550 or Perlite P2040 from World Minerals Europe. These particles are sold as matting agents for coatings. They are in the form of a white powder and have a crystalline silica content of less than 0.1% by weight, relative to the total weight of the composition.

[0131] Preferably, the perlite particles according to the invention have a particle size distribution such that at least 50% of the particles have a size of less than 25 μm, preferably less than 20 μm. Additionally, they preferably have a particle size distribution such that 90% by weight of the particles have a size of less than 55 μm and preferably less than 40 μm. Furthermore, preferably 90% by weight of the particles have a size greater than 5 μm.

[0132] Mention may be made of boron nitride particles such as PUHP1030L of Saint Gobain Ceramics, UHP-1010 of Carborundum, Ronaflair Extender of Merck, Covalumine Atlas White AS of Sensient, Boroneige 601 of ESK, PUHP3008 of Saint Gobain Ceramics.

[0133] Clay is a product that is already well-known per se and is described, for example, in the publication Minéralogie des argiles [Mineralogy of Clays], S. Caillère, S. Hénin, M. Rautureau, 2nd Edition, 1982, Masson.

[0134] Clay is a silicate containing cations that may be selected from calcium cations, magnesium cations, aluminum cations, sodium cations, potassium cations, and lithium cations, as well as mixtures thereof.

[0135] Examples of such products that may be mentioned include clays of the smectite group, such as montmorillonite, saponite, bentonite, beidellite, and talc, as well as clays of the vermiculite group, magnesian montmorillonite, and chlorite.

[0136] Clay may be of natural or synthetic origin. Preferably, a clay that is compatible and acceptable on cosmetic keratin fibers such as hair is used.

[0137] The clay may be selected from montmorillonite, bentonite, saponite, attapulgite, sepiolite, and mixtures thereof. Preferably, the clay is bentonite or saponite.

[0138] The clay may be selected from organophilic clays.

[0139] An organophilic clay is a clay modified with a chemical compound selected from quaternary amines, tertiary amines, acetamides, imidazolines, amine soaps, fatty sulfates, alkylaryl sulfonates, and amine oxides, as well as mixtures thereof.

[0140] Preferably, the organophilic clay according to the present invention is a clay modified with a chemical compound selected from quaternary amines.

[0141] Examples of organophilic clays that may be mentioned include: quaternary ammonium-18 bentonites, such as those sold by Elementis under the names Bentone 3, Bentone 38, and Bentone 38V, by United Catalyst under the name Tixogel VP, and by Southern Clay under the names Claytone 34, Claytone 40, and Claytone XL; stearalkonium bentonites, such as those sold by Elementis under the name Bentone 27V, by United Catalyst under the name Tixogel LG, and by Southern Clay under the names Claytone AF and Claytone APA; and quaternary ammonium-18 / benzalkonium bentonites, such as those sold by Southern Clay under the names Claytone HT and Claytone PS.

[0142] The organophilic clay is particularly selected from modified lithium montmorillonite, such as C 10 -C 12 lithium montmorillonite modified with ammonium fatty acid salts, especially dimethyldistearylammonium chloride and benzyl dimethyloctadecylammonium chloride.

[0143] The clay is particularly selected from montmorillonite and kaolin.

[0144] Particularly preferred particles for absorbing sebum are silica powders, especially precipitated silica powders, and more specifically precipitated silica coated with wax, boron nitride, acrylic polymer powder.

[0145] Preferably, the particles have a number average size of from 50 nm to 350 μm, more preferably from 100 nm to 100 μm and even more preferably from 0.5 to 100 μm.

[0146] Fiber-Based Layer

[0147] According to the present invention, one or more layers based on fibers can be all fiber-based layers that can effectively absorb the active substance from the hydrogel and deliver it to the skin.

[0148] One or more layers based on fibers for use in the present invention comprise a compound (such as a salt of a fiber, such as calcium alginate, etc.) capable of reacting with a water-soluble alkali metal salt (such as disodium EDTA or sodium citrate, etc.) contained in the hydrogel layer to form an alkali metal salt (such as sodium alginate), wherein the obtained alkali metal salt is a hydrophilic substance. The obtained hydrophilic alkali metal salt can thus absorb the water and / or aqueous substance containing the water-soluble component from the hydrogel layer, so that the water and water-soluble components in the gel are continuously transferred from the gel to the fiber-based layer. Thus, the fiber-based layer delivers the water and water-soluble components to the keratin material, especially the skin.

[0149] The present invention relates to a sheet of a fiber-based layer. When the fiber-based layer is used as part of a sheet, the material of the fiber-based layer is a material that can absorb the active substance from the hydrogel and deliver it to the skin, wherein the fiber-based layer is based on at least one of the following, selected from: natural fibers, man-made natural fibers, and / or synthetic fibers, which can be all fiber-based layers that can effectively absorb the active substance from the hydrogel and deliver it to the skin, such as natural (biological) cellulose fibers or manufactured (biological) cellulose fibers, preferably based on alginate fibers and cellulose fibers, and mixtures thereof. Two or more selected from the above substances can be used in combination.

[0150] In one embodiment of the present invention, preferably, the fiber-based layer is based on alginate fibers and other fibers.

[0151] In one embodiment of the present invention, preferably, the fiber-based layer is based on alginate fibers and cellulose fibers.

[0152] In one embodiment of the present invention, the compound used in one or more fiber-based layers capable of reacting with the water-soluble alkali metal salt contained in the hydrogel layer is a divalent salt of a fiber, such as calcium alginate.

[0153] In one embodiment of the present invention, the weight of the fiber-based layer is 18 g / m 2 to 60 g / m 2 .

[0154] In one embodiment of the present invention, the fiber-based layer is an alginate-based layer, which contains 0.1 wt% - 50 wt% of calcium alginate fibers and 50 wt% - 99.9 wt% of at least one other cellulose fiber relative to the total weight of the composition.

[0155] In one embodiment, the fiber-based layer (preferably the alginate-based layer) of the present invention can effectively absorb the active substance from the hydrogel and deliver it to the keratin material, especially the skin. The fiber-based layer (preferably the alginate-based layer) of the present invention has excellent delivery ability when applied to the keratin material, especially the skin.

[0156] Facial Mask

[0157] According to the present invention, the present fiber-based layer is coated on the hydrogel layer, and the present fiber-based layer can help the delivery of the active substance from the hydrogel, so that the mask highly improves the delivery ability of the hydrogel-type mask and makes the hydrogel layer change from a "supporting material" to a truly functional layer.

[0158] The folded mask according to the present invention can be made of two or more layers. Thus, for example, the mask can include two or more stacked layers. If a layered mask is used, the materials of each stacked layer can be the same or different from each other. For example, the layered mask can be prepared by laminating one or more of the above layers or sheets, such as by a thermal coating method.

[0159] According to the desired use and characteristics of the mask, the mask can be made in a wide variety of shapes and forms, such as flat pads, thick pads, and thin sheets with irregular thicknesses. The mask is usually designed to conform to the area of the keratin material (especially the skin, and more preferably the facial skin) that requires local application. For example, when the mask is applied to the face, it is designed to correspond to the shape of the face as needed, avoiding the eye, nostril, and mouth areas.

[0160] The weight ratio of the hydrogel layer to the fiber-based layer coated on the hydrogel layer is from 99:1 to 80:20, preferably from 99:1 to 80:15, or from 99:1 to 85:15, or even from 98:2 to 90:10.

[0161] In one embodiment, in the present facial mask, the fiber-based layer (as the primer layer, i.e., the bottommost layer) is the layer in direct contact with the keratin material.

[0162] In view of the presence of active agents and hydrophilic substances beneficial to the keratin material (such as the skin) in the hydrogel layer, the facial mask of the present invention shows a great improvement in the high loading amount of active substances and hydrophilic substances, that is, the facial mask of the present invention is loaded with more active substances and hydrophilic substances so as to effectively provide them to the keratin material (such as the skin) and shows good skin conditioning effects, such as moisturizing, refreshing, smooth, and soft effects and has a long service life.

[0163] Active Agent

[0164] According to one embodiment of the present invention, the facial mask of the present invention may comprise at least one functional reagent (referred to as an active agent or an active substance), such as at least one active agent (preferably added to the hydrogel layer), for example selected from: drugs; exfoliants or moisturizers; depigmenting agents or anti-depigmenting agents; anti-glycation agents; anti-NO agents; reagents for stimulating the synthesis of dermal or epidermal macromolecules and / or for preventing their degradation; reagents for stimulating the proliferation of fibroblasts or keratinocytes and / or keratinocyte differentiation; muscle relaxants or dermo-decontracting agents; free radical scavengers or anti-pollution agents; tensioning agents; reagents acting on capillary circulation; of course, especially the following active agents, and mixtures thereof.

[0165] Among all the active agents that can be used in the present invention, particular mention may be made of: α- or β-hydroxy acids such as lactic acid, glycolic acid, citric acid, 5-octanoylsalicylic acid, α-hydroxydecanoic acid, α-hydroxylauric acid, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, α-hydroxybutyric acid, α-hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid, and salicylic acid.

[0166] It is also possible to use anti-acne agents such as salicylic acid or benzoyl peroxide, piroctone olamine (octopirox), D- and L-sulfur-containing amino acids, their salts and their N-acetyl derivatives such as N-acetylcysteine, or agents seeking to prevent skin aging and / or improve its condition, such as the above-mentioned α- and β-hydroxy acids, retinoids such as retinoic acid, retinol and its esters such as retinol propionate, retinol acetate or retinol palmitate, niacinamide, allantoin, aloe vera extract, azelaic acid, bisabolol, phytic acid, collagen, or agents stimulating collagen formation, vitamins such as vitamin C or its derivatives such as glucosyl ascorbate, vitamin E or its derivatives, vitamin A or its derivatives, vitamin F or its derivatives, the above-mentioned D- and L-sulfur-containing amino acids and their derivatives, elastin, N-acetyl-D-glucosamine, luteolin, or antioxidants such as green tea or its active ingredients, glycerol, synthetic laponite, caffeine, aromatic essential oils, colorants, free radical scavengers, humectants, depigmenting agents, agents improving skin color such as dihydroxyacetone or artificial tanning agents of the tyrosine ester type, lipid regulators, emollients, anti-wrinkle agents, keratolytic agents, fresheners, deodorants, anesthetics, nourishing agents and mixtures thereof. It is also possible to use bleaching agents such as kojic acid, ascorbyl phosphate, glucosyl ascorbate, ascorbic acid, and mixtures thereof.

[0167] In the case of a face mask, it is also possible to use active agents for improving skin condition such as humectants or agents for improving the natural lipid barrier such as ceramides, cholesterol sulfate and / or fatty acids, and mixtures thereof. It is also possible to use enzymes active on the skin such as proteases, lipases, ceramidases and / or melanases, and mixtures thereof.

[0168] As other examples of active agents that can be applied to implement the present invention, there are the following agents: drugs, peptides, proteins, detectable labels, contrast agents, analgesics, anesthetics, antibacterial agents, anti-yeast agents, antifungal agents, antiviral agents, anti-dermatitis agents, antipruritics, antiemetics, vasoprotective agents, anti-motion sickness agents, anti-irritants, anti-inflammatory agents, immunomodulators, anti-hyperkeratosis agents, dry skin treatment agents, antiperspirants, anti-psoriasis agents, anti-dandruff agents, anti-aging agents, anti-asthma agents and bronchodilators, sunscreens, antihistamines, healing agents, corticosteroids, tanning agents, and mixtures thereof.

[0169] The content of at least one active agent in the first composition and / or the second composition can be adjusted according to the intended purpose of the face mask.

[0170] Adjuvant

[0171] In a known manner, the facial mask of the present invention may also contain adjuvants common in beauty and / or dermatology, such as preservatives, antioxidants, pH regulators (acidic or alkaline), fragrances, fillers, fungicides, odor absorbers, colorants (pigments and dyes), emulsifiers, and lipid vesicles.

[0172] Needless to say, those skilled in the art will carefully select such or these optional additional compound(s) and / or their amounts such that the benefits of the second composition according to the present invention are not or are substantially not adversely affected by the intended addition.

[0173] Methods and Uses

[0174] The facial mask or skin wound dressing according to the present invention can be prepared by including the following steps:

[0175] -(1) Providing a fiber-based layer; and

[0176] -(2) Providing a hydrogel layer containing one or more active agents,

[0177] -(3) Coating the fiber-based layer on the hydrogel layer.

[0178] According to one embodiment, step (3) of coating the fiber-based layer on the hydrogel layer is carried out by a thermal coating method.

[0179] According to one embodiment, the facial mask according to the present invention is prepared by a method including the following steps:

[0180] - Fixing the fabric on a roller and inserting one end between two pressure rollers,

[0181] - Keeping the hydrogel in a tank at a temperature of 50 - 70 °C,

[0182] - Dropping a batch of hot fluid hydrogel on top of the fabric,

[0183] - Fixing the distance between the two rollers at 0.1 - 0.2 cm,

[0184] - Pressing and cooling the hydrogel layer with two pressure rollers having a cooling system,

[0185] - Die-cutting the final facial mask into a facial shape (usually 300 - 350 cm 2 , with eye, nose, and mouth holes).

[0186] According to one embodiment, the facial mask according to the present invention can be used for caring for keratin materials, preferably the skin, and more preferably the facial skin; and can also be used for treating skin wounds, for preventing the formation of postoperative adhesions or for filling or repairing osteochondral defects, etc. This use can be manifested as a method for treating skin wounds, preventing the formation of postoperative adhesions or filling or repairing osteochondral defects, including applying the facial mask of the present invention or the skin wound dressing of the present invention at the required position.

[0187] While the broad numerical ranges and parameters set forth in this invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. However, any numerical value inherently contains certain errors necessarily resulting from the standard deviation existing in its respective measurement. The following examples are intended to illustrate the invention without limiting the scope thereby.

[0188] The following examples are intended to illustrate the compositions and methods according to the present invention, but do not limit the scope of the present invention in any way. Unless otherwise indicated, all parts and percentages in the examples are given by weight, and all measurements are obtained at approximately 25 °C.

[0189] Description of the Drawings

[0190] Figure 1 The coating method during the preparation of this facial mask is shown. Examples

[0191] Example 1: Preparation of Fiber-Based Layer

[0192] Preparation scheme:

[0193] The alginate-based layer is prepared from fibers obtained from Eastex Corporation under the name E8080142 (20 wt% calcium alginate, 80 wt% cellulose, fabric density 40 g / m 2 )

[0194] Example 2: Preparation of Hydrogel Layer

[0195] Preparation scheme:

[0196] The hydrogel layer formulation is as follows:

[0197]

[0198] Method:

[0199] 1. Add all the ingredients to an oven

[0200] 2. Heat the mixture to 70 - 80 °C and mix until all the ingredients are fully dissolved

[0201] 3. Stop mixing and keep the mixture at 80 - 85 °C

[0202] 4. Cool to room temperature

[0203] Example 3: Preparation of Facial Mask

[0204] The alginate-based layer as above is brought into intimate contact with the hydrogel layer obtained as above by a thermal coating method.

[0205] Preparation protocol:

[0206] The coating method is as shown in the following figure Figure 1 shown below.

[0207] Method:

[0208] 1. Fix the fabric on a roller and insert one end between two pressure rollers,

[0209] 2. Keep the hydrogel in a tank at a temperature of 50 - 60 °C,

[0210] 3. Drop a batch of hot fluid hydrogel on top of the fabric,

[0211] 4. Fix the distance between the two rollers at 0.1 - 0.2 cm,

[0212] 5. Press and cool the hydrogel layer with two pressure rollers having a cooling system,

[0213] 6. Die-cut the final facial mask into a facial shape (usually 300 - 350 cm 2 , with eye, nose and mouth holes).

[0214] Comparative example: (5*5 cm 2 fabric) Preparation

[0215] Prepare the following examples:

[0216] 1. Comparative Example 1:

[0217] Prepare the facial mask of Comparative Example 1 by coating a hydrogel layer on top of an alginate-based layer (the compositions of the hydrogel layer preparation and the alginate-based layer are as follows)

[0218] Preparation 1

[0219] INCI wt% Niacinamide 0 Caffeine 2.5 Xanthan Gum 0.2 Carrageenan 0.6 Glucomannan 0.4 Glycerin 8 Sodium Citrate 1.5 Water Up to 100

[0220] Fabric 1

[0221] Components wt% Calcium Alginate Fibers 20 Cellulose Fibers 80 Fabric Weight <![CDATA[40g / m 2 >

[0222] Preparation protocol:

[0223] 1. Fix the fabric on a roller and insert one end between two pressure rollers,

[0224] 2. Keep the hydrogel preparation 1 in a tank at a temperature of 60 °C.

[0225] 3. Drop the hot fluid hydrogel batch on top of the fabric.

[0226] 4. Fix the distance between the two rollers at 0.15 cm.

[0227] 5. Press and cool the hydrogel layer with two pressure rollers equipped with a cooling system.

[0228] 6. Die-cut the final facial mask into small square shapes (5*5 cm 2 fabric).

[0229] 2. Comparative Example 2:

[0230] Prepare the facial mask of Comparative Example 2 by impregnating the alginate fabric with the following functional preparation.

[0231] Preparation 2

[0232] INCI wt% Caffeine 2.5 Xanthan Gum 0.5 Glycerin 8 Sodium Citrate 1.5 Water Up to 100

[0233] Fabric 1

[0234] Components wt% Calcium Alginate Fibers 20 Cellulose Fibers 80 Fabric Weight <![CDATA[40 g / m 2 >

[0235] Preparation scheme:

[0236] 1. Cut the fabric into shapes of 5 cm * 5 cm.

[0237] 2. Immerse the small pieces of fabric in 2.5 grams of juice.

[0238] 3. Lift the fabric out.

[0239] 3. Comparative Example 3:

[0240] Prepare the facial mask of Comparative Example 3 to form a hydrogel layer without a fabric layer. The preparation is the same as that of Example 1.

[0241] Preparation 3

[0242] INCI wt% Niacinamide 0 Caffeine 2.5 Xanthan Gum 0.2 Carrageenan 0.6 Glucomannan 0.4 Glycerin 8 Sodium Citrate 1.5 Water Up to 100

[0243] Preparation scheme:

[0244] 1. Fix the fabric on the roller and insert one end between the two pressure rollers.

[0245] 2. Keep the hydrogel preparation 1 in a tank at a temperature of 50 - 60 °C.

[0246] 3. Drop the hot fluid hydrogel batch on top of a plastic or steel plate.

[0247] 4. Fix the distance between the two rollers at 0.15 cm.

[0248] 5. Press and cool the hydrogel layer with two pressure rollers equipped with a cooling system.

[0249] 6. Die-cut the final facial mask into small square shapes (5*5 cm 2 ).

[0250] Evaluation

[0251] 1. Delivery Capacity

[0252] Evaluation plan:

[0253] - Facial mask (1) (the facial mask of the present invention): Coat 2.5 g of hydrogel on top of 20 wt% alginate fibers; then apply the alginate fabric side on a flat plate for 20 minutes (A); then measure the total amount of functional liquid remaining on the plate;

[0254] - Facial mask (2) (a comparative facial mask containing only an alginate-based layer): Provide 2.5 g of the same functional liquid as shown in Table 1 to impregnate the alginate-based layer, then apply the alginate fabric side on a flat plate for 20 minutes (A); then measure the total amount of functional liquid remaining on the plate; and measure the content of active substances remaining on the plate;

[0255] - Facial mask (3) (a comparative facial mask including only a hydrogel layer): Prepare a hydrogel layer without alginate fibers, weighing 2.5 g, then apply the hydrogel side on a plate for 20 minutes (B), then measure the total amount of functional liquid remaining on the plate; measure the content of active substances remaining on the plate;

[0256] - Facial mask (4) (a comparative facial mask using a hydrogel layer to deliver active substances): Coat 2.5 g of hydrogel on top of 20 wt% alginate fibers; then apply the hydrogel fabric side on a flat plate for 20 minutes (B); then measure the total amount of functional liquid remaining on the plate; measure the content of active substances remaining on the plate.

[0257] Evaluation results

[0258] The evaluation results are shown in the following table.

[0259]

[0260] The results show that the active substances delivered by the facial mask (1) (the facial mask of the present invention) are much greater than those delivered by the facial masks (comparative facial masks not according to the present invention).

[0261] 2. Functional Liquid Loading on Facial Mask

[0262] Evaluation plan:

[0263] - Mask (1) (the mask of the present invention): Coat 33 g of a hydrogel layer on top of the alginate fiber and measure the weight of the hydrogel loaded on the alginate fiber.

[0264] - Mask (2) (a comparative mask containing only an alginate-based layer): Immerse the alginate fabric in 33 g of a functional liquid as shown in Table 1, take it out, and measure the amount of the functional liquid loaded on the mask.

[0265] The evaluation results are shown in the following table.

[0266]

[0267] The results show that the weight of the functional liquid loaded on Mask (2) is 28 g; while the mask according to the present invention has 33 g of the functional liquid remaining on the mask.

[0268] Conclusion

[0269] Compared with the prior art (only a hydrogel layer or only an alginate-based layer), the mask of the present invention shows a great improvement in terms of high active substance loading and good delivery ability, that is, the mask of the present invention loads more active substances to effectively provide them to the skin and shows good skin conditioning effects such as moisturizing, refreshing, smooth, soft effects and a long-lasting usage time.

Claims

1. A facial mask for caring for keratin materials, comprising: (1) at least one hydrogel layer, (2) at least one fiber-based layer comprising alginate fibers, wherein one or more of said hydrogel layers comprise water, at least one gel-forming composition, and at least one water-soluble alkali metal salt; wherein the alginate fibers contained in said fiber-based layer are capable of reacting with the water-soluble alkali metal salt contained in said hydrogel layer to form a hydrophilic alkali metal salt; and wherein one or more of the fiber-based layers are layers closer to the keratin material than any hydrogel layer present in the facial mask after application.

2. The facial mask according to claim 1, wherein said fiber-based layer is based on alginate fibers and cellulose fibers.

3. The facial mask as claimed in any one of the preceding claims, wherein said gel-forming composition comprises at least one hydrophilic thickener.

4. The facial mask as claimed in claim 3, wherein said hydrophilic thickener is selected from: - anionic, cationic, amphoteric or non-ionic chitin or chitosan polymers; - cellulose polymers; - vinyl polymers; - optionally modified natural source polymers; - alginates and carrageenans; - mucopolysaccharides; and - mixtures thereof.

5. The facial mask as claimed in claim 4, wherein said cellulose polymer comprises (C1-C3) hydroxyalkyl cellulose.

6. The facial mask as claimed in claim 5, wherein said cellulose polymer is selected from hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxymethyl cellulose, ethyl hydroxyethyl cellulose, carboxymethyl cellulose, and quaternized derivatives of cellulose.

7. The facial mask as claimed in claim 4, wherein said vinyl polymer comprises copolymers of polyvinylpyrrolidone, methyl vinyl ether and maleic anhydride, copolymers of vinyl acetate and crotonic acid, copolymers of vinylpyrrolidone and vinyl acetate; copolymers of vinylpyrrolidone and caprolactam; polyvinyl alcohol.

8. The facial mask as claimed in claim 4, wherein said natural source polymer comprises galactomannan and its derivatives.

9. The facial mask as claimed in claim 4, wherein said natural source polymer comprises carrageenan, konjac gum, gellan gum, locust bean gum, fenugreek gum, sterculia gum, tragacanth gum, gum arabic, acacia gum, guar gum, carboxymethyl guar gum, hydroxypropyl guar gum, hydroxypropyl guar gum modified with sodium methyl carboxylate groups, xanthan gum and its derivatives.

10. The facial mask as claimed in claim 4, wherein said carrageenan comprises carrageenan of the μ, κ, v, ι or λθ type, and mixtures in all proportions thereof.

11. The facial mask as claimed in claim 4, wherein said carrageenan is of the κ type.

12. The facial mask as claimed in claim 4, wherein said mucopolysaccharide comprises hyaluronic acid.

13. The facial mask as claimed in claim 1, wherein said water-soluble alkali metal salt is selected from disodium EDTA or sodium citrate.

14. The facial mask as claimed in claim 1, wherein one or more of said hydrogel layers comprise at least one active agent.

15. The facial mask as claimed in claim 14, wherein said active agent is selected from: a reagent for improving the condition of keratin materials; a drug; an anti-aging agent; an anti-acne agent; an exfoliant or a humectant; a depigmenting agent or an anti-depigmenting agent; an anti-glycation agent; an anti-NO agent; a reagent for stimulating the synthesis of dermal or epidermal macromolecules and / or for preventing their degradation; a reagent for stimulating the proliferation of fibroblasts or keratinocytes and / or the differentiation of keratinocytes; a muscle relaxant or a skin relaxant; a free radical scavenger or an anti-pollution agent; a tightening agent; a reagent acting on capillary circulation.

16. The facial mask as claimed in claim 1, wherein said alginate fiber is a divalent salt which is capable of reacting with disodium EDTA or sodium citrate contained in the hydrogel layer to form sodium alginate.

17. The facial mask as claimed in claim 16, wherein said divalent salt is calcium alginate.

18. The facial mask as claimed in claim 1, wherein said fiber-based layer is an alginate-based layer, comprising 0.1% to 50% by weight of calcium alginate fibers and 50% to 99.9% by weight of cellulose fibers relative to the total weight of the composition.

19. The facial mask as claimed in claim 1, wherein said keratin material is skin.

20. The facial mask as claimed in claim 1, wherein said keratin material is facial skin.

21. A method for preparing the facial mask as claimed in any one of claims 1 - 20, comprising the following steps: - providing a fiber-based layer comprising alginate fibers; - providing a hydrogel layer comprising one or more active agents, - coating the fiber-based layer on said hydrogel layer.

22. The method as claimed in claim 21, wherein said hydrogel layer is prepared from a substance comprising water, at least one gel-forming composition, and at least one water-soluble alkali metal salt.

23. The method as claimed in claim 21 or 22, wherein the step of coating the fiber-based layer on said hydrogel layer is carried out by a thermal coating method.

24. The method as claimed in claim 21, wherein said fiber-based layer is an alginate-based layer, which is prepared from 0.1% to 50% by weight of calcium alginate fibers and 50% to 99.9% by weight of cellulose fibers.

25. Use of the facial mask as claimed in any one of claims 1 - 20 and the facial mask obtained by the method as claimed in any one of claims 21 to 24, for caring for keratin materials, wherein at least one fiber-based layer is a layer closer to the keratin material than all the hydrogel layers present in the facial mask.

26. The use as claimed in claim 25, wherein said keratin material is skin.

27. The use as claimed in claim 25, wherein said keratin material is facial skin.

28. A non-therapeutic method involving the use of a facial mask as claimed in any one of claims 1 to 20 above and a facial mask obtained by the method as claimed in any one of claims 21 to 24 above, wherein a fiber-based layer is applied to the keratin material such that the fiber-based layer is in direct contact with the keratin material.

29. The non-therapeutic method as claimed in claim 28, wherein the keratin material is skin.

30. The non-therapeutic method as claimed in claim 28, wherein the keratin material is facial skin.

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