Space brain science animal experiment optical genetic device

Abstract

The application provides a spatial brain science animal experiment optical genetic device, comprising: an optical genetic component and a transmitting and receiving component; the optical genetic component comprises an OLED component, a sensing layer film and a quantum dot film; the sensing layer film and the quantum dot film are connected, and the OLED component and the quantum dot film are connected; the sensing layer film is connected with the transmitting and receiving component. The application realizes non-invasive optical genetic regulation, avoids the problems that experimental animals are prone to death under the conditions of high complexity operation and space station pollution, and greatly reduces the mortality of experimental animals.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of optical genetic technology, in particular, to a spatial brain science animal experiment optical genetic device. BACKGROUND

[0002] The existing optical genetic device causes trauma to the animal body when installed on the animal body, and in the case of high complexity operation and space station pollution, the mortality rate of experimental animals is greatly increased when corresponding experiments are carried out in the space station. The existing optical genetic device needs to perform craniotomy surgery on the experimental animal (such as a mouse) to bury the optical fiber in the specific brain area of the experimental animal when installing, and the experimental animal will have a pain after the operation. Too violent activity may cause bleeding of the wound in the operation area, which threatens the life safety of the experimental animal, in addition, the wound caused by the operation is easy to cause viral infection, which is not conducive to the survival of the experimental animal. The present application realizes non-invasive optical genetic non-invasive regulation by using OLED devices in combination with quantum dot films, thereby avoiding the above problems.

[0003] The patent document with publication number CN102283137A discloses an animal behavior testing platform for optical genetic regulation, which is used for behavior testing of test animals. The testing platform includes a central control system, an environment control system, a behavior monitoring system, a photoelectric detection and regulation system, and a shell device for fixing the above systems. By combining optical genetic neural regulation technology with electrophysiology and behavior testing, a standardized and integrated behavior testing platform for testing animal optical genetic regulation is established. However, when testing is performed using the testing platform of the patent document, craniotomy surgery is still required, which still causes trauma to the experimental animal.

[0004] The patent document with publication number CN207412159U discloses an animal neural function detection device based on optical genetic-electrophysiological technology, which includes an electrophysiological signal recording system, a laser and an optical fiber. The tip of the optical fiber is coated with a plurality of metal conductive wires on the outer circumferential surface of the tip, and the length direction of the metal conductive wires is consistent with the length direction of the optical fiber. The electrophysiological signal recording system includes a measurement electrode group, which includes a plurality of microelectrodes for detecting brain neural cell electrical signals, and each microelectrode is connected to each metal conductive wire. However, when installing the detection device of the patent document, craniotomy surgery is still required, which still causes trauma to the experimental animal. SUMMARY

[0005] In view of the defects in the prior art, the purpose of the present application is to provide a spatial brain science animal experiment optical genetic device.

[0006] The application provides a spatial brain science animal experiment optical genetic device, which comprises an optical genetic component and a transmitting and receiving component.

[0007] The optical genetic component comprises an OLED component, a sensing layer film and a quantum dot film; the sensing layer film is connected with the quantum dot film, and the OLED component is connected with the quantum dot film.

[0008] The sensing layer film is connected with the transmitting and receiving component.

[0009] Preferably, the optical genetic component further comprises a peripheral component, and the peripheral component comprises a first protective layer film and a second protective layer film.

[0010] The sensing layer film, the quantum dot film and the OLED component are arranged between the first protective layer film and the second protective layer film.

[0011] The quantum dot film is arranged between the sensing layer film and the OLED component, the sensing layer film is arranged close to the first protective layer film, and the OLED component is arranged close to the second protective layer film.

[0012] Preferably, the OLED component comprises a thin film circuit negative electrode, an organic light-emitting semiconductor, a thin film circuit positive electrode and a first connecting wire.

[0013] The organic light-emitting semiconductor is arranged between the thin film circuit negative electrode and the thin film circuit positive electrode; one end of the thin film circuit negative electrode and the thin film circuit positive electrode is connected with one end of the first connecting wire, and the other end of the first connecting wire is used for connecting a cranial nail.

[0014] The thin film circuit negative electrode is arranged close to the quantum dot film, and the thin film circuit positive electrode is arranged close to the second protective layer film.

[0015] Preferably, the transmitting and receiving component comprises a control and power supply component, a shell and a fixing component.

[0016] The control and power supply component is arranged in the shell, and the fixing component is used for fixing the shell on the brain of an animal body.

[0017] The control and power supply component is electrically connected with the optical genetic component.

[0018] Preferably, the control and power supply component comprises a power supply component and a control module.

[0019] The power supply component is used for supplying power to the control module; and the optical genetic component is connected with the control module and the power supply component.

[0020] Preferably, the power supply assembly comprises a wireless power supply module and a second supplementary power source;

[0021] The wireless power supply module is configured to supply power to the control module and the optogenetic assembly, and the second supplementary power source is configured to supply power to the control module.

[0022] Preferably, the control module comprises a control circuit, a second connecting wire, a wireless communication module, a signal receiving and amplifying module, and a data storage unit.

[0023] One end of the second connecting wire is configured to be connected to a cranial nail, and the other end of the second connecting wire is connected to the data storage unit.

[0024] The control circuit is connected to the data storage unit and the wireless communication module.

[0025] The data storage unit and the signal receiving and amplifying module are configured to transmit signals, and the wireless communication module and a master control unit are configured to transmit signals.

[0026] The power supply assembly is configured to supply power to the control circuit, the wireless communication module, the signal receiving and amplifying module, and the data storage unit.

[0027] Preferably, the shell is a polyether ether ketone shell, and the inner side of the polyether ether ketone shell is sprayed with a carbon fiber film layer.

[0028] Preferably, the control assembly comprises a control box shell and a master control unit, and the master control unit is arranged in the control box shell.

[0029] The master control unit is configured to adjust the optogenetic assembly and the emission and reception assembly.

[0030] Preferably, a usb interface, a typec interface, a SCSI interface, an RS122 interface, a short-distance wireless data transmission interface, an HD-SDI interface, an HDMI interface, a long-distance wireless data transmission port, a memory card interface, a situation fear module power interface, a gigabit Ethernet interface, a power supply 28V interface, a suction water pipe interface, a power supply 100V interface, a sugar water preference module power interface, and a switch button are arranged on a circumferential sidewall of the control box shell.

[0031] A laser switch, a wireless control switch, a laser opening prompt light, a touch screen manual control integrated switch, a gas control switch, a gas sampling control button, an ammeter, an electric shock opening prompt light, a water control switch, a water sampling control button, and a water meter are arranged on the circumferential sidewall of the control box shell.

[0032] An air-cooled heat dissipation interface is arranged on the circumferential sidewall of the control box shell.

[0033] Compared with the prior art, the present application has the following beneficial effects:

[0034] 1、The optical genetic module of the present application adopts a structure of connecting OLED system and quantum dot film in series, uses visible light emitted by organic fluorescent semiconductor to excite quantum dot film to emit monochromatic far red light which can penetrate biological tissues, realizes non-invasive optical genetic regulation, avoids the problem that experimental animals are prone to die under high complexity operation and space station pollution, and greatly reduces the mortality rate of experimental animals;

[0035] 2、The optical genetic module of the present application applies flexible electrode material to optical genetic device, solves the problem that traditional rigid OLED material cannot be used in space environment and experimental conditions due to its fragility and lack of flexibility, and greatly improves the operability and flexibility of space animal experiments;

[0036] 3、The present application adopts a head-mounted transmitting and receiving device, solves the problem that animals are inconvenient to move when implementing traditional optical genetic regulation technology under weightlessness and small activity space, and realizes remote control of optical genetic regulation. BRIEF DESCRIPTION OF DRAWINGS

[0037] Other features, objects and advantages of the present application will become more apparent from the following detailed description of non-limiting embodiments, made with reference to the accompanying drawings:

[0038] Figure 1 Fig. 1 is a structural schematic diagram of the optical genetic assembly of the present application;

[0039] Figure 2 Fig. 2 is a schematic diagram of the optical genetic assembly connected to the animal brain skull;

[0040] Figure 3 Fig. 3 is a schematic diagram of the transmitting and receiving assembly of the present application installed on the animal brain skull;

[0041] Figure 4 Fig. 4 is a structural schematic diagram of the transmitting and receiving assembly of the present application;

[0042] Figure 5 Fig. 5 is a partial schematic diagram of the control assembly of the present application Figure 1 ;

[0043] Figure 6 Fig. 6 is a perspective schematic diagram of the control assembly of the present application;

[0044] Figure 7 Fig. 7 is a structural schematic diagram of the anti-collision loosening groove;

[0045] Figure 8 Fig. 8 is a structural schematic diagram of the air-cooled heat dissipation interface;

[0046] Figure 9 Fig. 9 is a partial schematic diagram of the control assembly of the present applicationFigure 2 .

[0047] shown in the figure:

[0048] Optogenetic component 1 SCSI interface 304

[0049] First protective layer film 101 RS122 interface 305

[0050] Sensing layer film 102 short-range wireless data transmission interface 306

[0051] Quantum dot film 103 HD-SDI interface 307

[0052] Thin film circuit negative electrode 104 HDMI interface 308

[0053] Organic light-emitting semiconductor 105 long-range wireless data transmission port 309

[0054] Thin film circuit positive electrode 106 storage card interface 310

[0055] Second protective layer film 107 scenario fear module power supply interface 311

[0056] Connecting wire 108 Gigabit Ethernet interface 312

[0057] Brain skull nail 109 power supply 28V interface 313

[0058] Reference line 110 siphon water pipe interface 314

[0059] Transmitting and receiving component 2 power supply 100V interface 315

[0060] Skull nail connecting wire 201 sugar water preference module power supply interface 316

[0061] Power supply component 202 switch button 317

[0062] Control module 203 laser switch 318

[0063] Wireless communication module 204 wireless control switch 319

[0064] Data temporary storage unit 205 laser start prompt light 320

[0065] Wireless power supply module 206 touch screen manual control integrated switch 321

[0066] Second supplementary power supply 207 gas control switch 322

[0067] Signal receiving and amplifying module 208 gas sampling control button 323

[0068] Carbon fiber film layer 209 ammeter 324

[0069] Polyether ether ketone shell 210 Electric shock opening prompt light 325

[0070] Head-mounted elastic band 211 Water control switch 326

[0071] Control assembly 3 Water sample control button 327

[0072] Anti-collision loose groove 301 Water meter 328

[0073] USB interface 302 Air-cooled heat dissipation interface 329

[0074] Type C interface 303 DETAILED DESCRIPTION

[0075] The application will be described in detail below with specific embodiments. The following examples will help those skilled in the art to further understand the application, but do not limit the application in any form. It should be noted that those skilled in the art can make several changes and improvements without departing from the concept of the application. These are within the scope of the present application.

[0076] Example 1

[0077] As shown in 1-9, the embodiment provides a spatial brain science animal experiment optical genetic device, which comprises an optical genetic assembly 1 and a transmitting and receiving assembly 2. The optical genetic assembly 1 comprises an OLED assembly, a sensing layer film 102 and a quantum dot film 103. The sensing layer film 102 and the quantum dot film 103 are connected, the OLED assembly and the quantum dot film 103 are connected, and the sensing layer film 102 is connected with the transmitting and receiving assembly 2.

[0078] The optical genetic assembly 1 and the transmitting and receiving assembly 2 are wirelessly interacted through an induction coil. The transmitting and receiving assembly 2 is connected with the optical genetic assembly 1 through a skull nail connected wire, so as to control visible light excitation. The control assembly 3 is wirelessly interacted with a signal receiving and amplifying module 208 on the transmitting and receiving assembly 2. In addition, the sensing layer film 102 of the optical genetic assembly 1 is connected with the transmitting and receiving assembly 2 through a wire, and the recorded brain electrical signals are transmitted back. The transmitting and receiving assembly 2 realizes communication with the control assembly 3 through a wireless data transmission interface, without the need of a wire, and transmits in the air. The quantum dot film 103 is an organic polymer, which generates quantum dots, i.e. a semiconductor nanocrystal, in the inside through high temperature and other conditions. The OLED assembly and the quantum dot film 103 are divided by a substrate. One side of the substrate is deposited with the quantum dot film 103, and the other side is deposited with a thin film circuit negative electrode 104. The sensing layer film 102 and the quantum dot film 103 are connected through the substrate. The material of the substrate can be silicon carbide and the like.

[0079] The optogenetic assembly 1 further comprises a peripheral assembly, the peripheral assembly comprising a first protective layer film 101 and a second protective layer film 107, the sensing layer film 102, the quantum dot film 103 and the OLED assembly being arranged between the first protective layer film 101 and the second protective layer film 107, the quantum dot film 103 being located between the sensing layer film 102 and the OLED assembly, the sensing layer film 102 being arranged close to the first protective layer film 101, and the OLED assembly being arranged close to the second protective layer film 107.

[0080] The OLED assembly comprises a thin film circuit negative electrode 104, an organic light-emitting semiconductor 105, a thin film circuit positive electrode 106 and a first connecting wire 108, the organic light-emitting semiconductor 105 being arranged between the thin film circuit negative electrode 104 and the thin film circuit positive electrode 106; the thin film circuit negative electrode 104 and the thin film circuit positive electrode 106 are both connected to one end of the first connecting wire 108, the other end of the first connecting wire 108 being used for connecting the cranial nail, the thin film circuit negative electrode 104 being arranged close to the quantum dot film 103, and the thin film circuit positive electrode 106 being arranged close to the second protective layer film 107.

[0081] The transmitting and receiving assembly 2 comprises a control and power supply assembly, a shell 210 and a fixing assembly 211, the control and power supply assembly being arranged in the shell 210, the fixing assembly 211 being used for fixing the shell 210 on the brain of the animal body, and the control and power supply assembly being electrically connected with the optogenetic assembly 1.

[0082] The control and power supply assembly comprises a power supply assembly 202 and a control module 203, the power supply assembly 202 being used for supplying power to the control module 203; the optogenetic assembly 1 is connected with the control module 203 and the power supply assembly 202.

[0083] The power supply assembly 202 comprises a wireless power supply module 206 and a second supplementary power source 207, the wireless power supply module 206 being used for supplying power to the control module 203 and the optogenetic assembly 1, and the second supplementary power source 207 being used for supplying power to the control module 203.

[0084] The wireless power supply module 206 comprises an induction coil and wires connected with other components. The induction coil of the wireless power supply module 206 cooperates with the power supply coil in the space station to obtain electric energy by using the principle of electromagnetic induction. The wireless power supply module 206 is connected with the signal receiving and amplifying module 208, the data temporary storage unit 205 and the control circuit through wires to realize power supply. The second supplementary power source 207 contains a battery, which is directly connected with each component through wires to realize the switching from a standby state to a working state. The power supply assembly 202 supplies power to the optogenetic assembly through the cranial nail connecting wire. The power supply assembly 202 is similar to a transformer.

[0085] The control module 203 comprises a control circuit, a second connection wire 201, a wireless communication module 204, a signal receiving and amplifying module 208 and a data temporary storage unit 205. One end of the second connection wire 201 is used for connecting a cranial nail, and the other end of the second connection wire 201 is connected to the data temporary storage unit 205. The control circuit is connected with the data temporary storage unit 205 and the wireless communication module 204. The data temporary storage unit 205 and the signal receiving and amplifying module 208 perform signal transmission. The wireless communication module 204 and the main control unit perform signal transmission. The power supply assembly 202 is used for supplying power to the control circuit, the wireless communication module 204, the signal receiving and amplifying module 208 and the data temporary storage unit 205. The control circuit is specifically composed of a controller, an arithmetic unit and a line connected between them, and finally in the form of a chip. The data temporary storage unit 205 is specifically a memory. The signal receiving and amplifying module 208 comprises a signal receiver and a signal amplifier.

[0086] The signal receiving and amplifying module 208 transmits the received signal to the data temporary storage unit 205 and the control circuit through wireless transmission. The control circuit retrieves the data in the data temporary storage unit 205 through wired connection and performs operation, and transmits the signal to the optogenetic assembly 1 through the cranial nail connection wire. The optogenetic assembly 1 transmits the received signal back to the data temporary storage unit 205 through the cranial nail connection wire, and then transmits it back to the control circuit. After signal conversion in the control circuit, the signal is output to the control system through the wireless communication module 204.

[0087] The shell 210 is a polyether ether ketone shell, and the inner side of the polyether ether ketone shell is sprayed with a carbon fiber film layer 209.

[0088] The spatial brain science animal experiment optogenetic device of the embodiment further comprises a control assembly 3. The control assembly 3 comprises a control box shell and a main control unit. The main control unit is arranged in the control box shell, and is used for adjusting the optogenetic assembly 1 and the transmitting and receiving assembly 2. The main control unit is specifically a single-chip microcomputer.

[0089] A USB interface 302, a Type-C interface 303, a SCSI interface 304, an RS122 interface 3050, a short-distance wireless data transmission interface 306, an HD-SDI interface 307, an HDMI interface 308, a long-distance wireless data transmission port 309, a memory card interface 310, a phobic module power supply interface 311, a gigabit Ethernet interface 312, a 28V power supply interface 313, a suction pipe interface 314, a 100V power supply interface 315, a sugar preference module power supply interface 316, a switch button 317, a laser switch 318, a wireless control switch 319, a laser start prompt light 320, a touch screen manual control integrated switch 321, a gas control switch 322, a gas sample control button 323, an ammeter 324, a shock start prompt light 325, a water control switch 326, a water sample control button 327, and a water meter 328 are arranged on a circumferential side wall of the control box shell.

[0090] The space brain science animal experiment optogenetic device also includes a brain skull nail 109 and a reference line 110. The brain skull nail 109 bears the force of the dental cement on the skull, and avoids cracks in the dental cement caused by temperature and the like. The use method is as follows: after the operation is completed, a hole (not penetrating) is drilled on the skull, the brain skull nail 109 is nailed, and then the dental cement is added to fix the device applied to the brain. The reference line 110 is a ground line of the brain electrical signal, and is used to remove signal noise.

[0091] The OLED assembly includes a thin-film circuit negative electrode 104, a thin-film circuit positive electrode 106, and an organic light-emitting semiconductor 105. Under the driving of an electric field generated by the thin-film circuit negative electrode 104 and the thin-film circuit positive electrode 106, the organic light-emitting semiconductor 105 can be excited and emit visible light. After the quantum dot film 103 absorbs the visible light generated by the OLED assembly, monochromatic far-red light with a longer wavelength is released, which can penetrate biological tissues to achieve non-invasive and non-invasive optogenetic regulation.

[0092] The OLED assembly and the application of the quantum dot film 103 are combined in the embodiment, non-invasive optogenetic regulation and low-energy light-emitting effects are achieved, flexible materials are used as the substrate of the OLED assembly, the OLED assembly has good flexibility, a light weight, and low power consumption, and has strong wearability. The OLED assembly is a safe and efficient device that can be applied to experimental animals in a space environment.

[0093] The control assembly 3 integrates circuit control, signal transmission, real-time monitoring, sample control, and state prompting, and realizes integrated control of various modules. The power supply interface, the water and gas control switches, and the air-cooled heat dissipation interface are respectively connected with corresponding main systems in the spacecraft, so that resources are reasonably utilized.

[0094] The holes and electrons in the organic light-emitting semiconductor 105 between the positive electrode 106 and the negative electrode of the thin-film circuit in the optogenetic assembly 1 migrate to the light-emitting layer under the driving of the electric field, respectively by the hole transport layer and the electron transport layer, and energy excitons are generated when the two meet, which excite light-emitting photons to generate visible light. The quantum dot film 103 is a nanoscale semiconductor that emits far-red light with lower energy after absorbing visible light. Since the transmittance of far-red light with longer wavelength in biological tissues is high, and the far-red light generated by quantum dot excitation is monochromatic light, the far-red light can penetrate the brain tissue to directly activate the light-sensitive protein on the neuron cell, thereby activating specific neurons, achieving non-implantable and non-invasive optogenetic regulation, and the sensing layer film 102 can record the field potential after light activation and transmit it back to the signal processing system to verify the activation degree of the neuron, thereby proving that the neuron cell has been effectively regulated by optogenetics.

[0095] The present embodiment combines the application of OLED assembly and quantum dot film 103, achieving the effects of non-invasive optogenetic regulation and low-energy light emission. The OLED assembly uses flexible material as the substrate, has good flexibility, light weight, and low power consumption, and is a safe and efficient device that can be used in space environment.

[0096] The head-mounted transmitter-receiver module has two power supply modes: wireless power supply and second supplementary power supply 207. External signals are first amplified by the signal receiving and amplifying module 208, temporarily stored in the data temporary storage unit 205, processed by the signal processing module, transmitted to the control circuit through the wireless communication module 204, and controlled through the cranial connection wire to control the optogenetic assembly 1.

[0097] Example 2

[0098] Those skilled in the art can understand the present embodiment as a more specific description of embodiment 1.

[0099] As Figures 1-9 shown, the present embodiment provides a spatial brain science animal experiment optogenetic device, which includes an optogenetic assembly 1, a transmitter-receiver assembly 2, and a control assembly 3.

[0100] The optogenetic assembly 1 comprises a flexible OLED system, a quantum dot film 103, a sensing layer film 102 and a peripheral system. The flexible OLED system comprises a thin film circuit negative electrode 104, a thin film circuit positive electrode 106 and an organic light-emitting semiconductor 105. Under the driving of the electric field generated by the thin film circuit negative electrode 104 and the thin film circuit positive electrode 106, the organic light-emitting semiconductor 105 can be excited and emit visible light. The quantum dot film 105 absorbs the visible light generated by the flexible OLED system and releases monochromatic far-red light with longer wavelength, which can penetrate biological tissues to achieve non-invasive and non-invasive optogenetic regulation. The peripheral system comprises a first protective layer film 101 and a second protective layer film 107 and a wire 108, which functions to conduct current. The sensing layer film 102 can record the field potential generated by neuronal activity and output through the wire 108.

[0101] The transmitting and receiving assembly comprises circuit system, shell 210 and fixing assembly 211, and the transmitting and receiving assembly is a head-mounted transmitter-receiver. The circuit system comprises power supply assembly 202 and control module 203. The power supply assembly comprises wireless power supply module 206 and second supplementary power supply 207; the control module 203 comprises cranial connection wire 201, wireless communication module 204, signal receiving and amplifying module 208 and data temporary storage unit 205. The signal receiving and amplifying module 208 is in the shape of a stick and is located at the top end of the head-mounted transmitter-receiver element, which can realize signal amplification function. The shell 210 is in the shape of a cylinder and comprises polyether ether ketone shell and carbon fiber film layer 209 sprayed on the inner side thereof. The fixing assembly 211 comprises head-mounted elastic band.

[0102] The control assembly 3 comprises a box body and front and rear control panels. The box body is provided with a forced air cooling interface 329 connected with a cooling system of the spacecraft. The front control panel is provided with a switch button 317, a USB interface 302, a type-C interface 303, a SCSI interface 304, a RS122 interface 305, a short-distance wireless data transmission interface 306, an HD-SDI interface 307, an HDMI interface 308, a long-distance wireless data transmission port 309, and a gigabit Ethernet interface 312 for transmitting signals with the outside world; a 28V power supply interface and a 100V power supply interface are arranged to work at two voltages respectively, avoiding downtime caused by failure of a power supply system at a certain voltage; a suction water pipe interface 314 is arranged; a situation fear module power supply interface 311 and a sugar water preference module power supply interface 316 are arranged. The interfaces on the front side of the control panel are fixed by the anti-collision loose grooves 101. The rear side of the control panel is provided with an ammeter 324 and a water gauge 328 to monitor the parameter changes of the situation fear memory module and the air and water replacement module in real time; an air sampling control 323 and a drinking water sampling control 327 are arranged respectively to adjust the air and water inflow and outflow of the air and water replacement module; a laser switch 318 and a wireless control switch 319, a touch screen manual control integrated switch 321, an air control switch 322 and a water control switch 326 are arranged to realize integrated control of each module. The situation fear memory module and the air and water replacement module are two experimental modules on the animal experiment platform.

[0103] The application realizes non-invasive optical genetic regulation, avoids the problem that experimental animals are prone to death in the case of high complexity operation and space station pollution, and greatly reduces the mortality rate of experimental animals.

[0104] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0105] The specific embodiments of the application are described above. It should be understood that the application is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essential content of the application. The embodiments of the present application and the features in the embodiments can be arbitrarily combined with each other without conflict.

Claims

1. A space brain science animal experiment optogenetic device, characterized by: include: Optogenetic component (1) and transmitter-receiver component (2); The optogenetic component (1) comprises an OLED component, a sensing layer film (102) and a quantum dot film (103); the sensing layer film (102) and the quantum dot film (103) are connected, and the OLED component and the quantum dot film (103) are connected; The sensing layer film (102) is connected to the transmitting and receiving component (2); The quantum dot film (103) is located between the sensing layer film (102) and the OLED component; The OLED component comprises a thin film circuit cathode (104), an organic light-emitting semiconductor (105), a thin film circuit anode (106), and a first connecting wire (108); The organic light-emitting semiconductor (105) is arranged between the thin film circuit cathode (104) and the thin film circuit anode (106); The thin film circuit negative electrode (104) and the thin film circuit positive electrode (106) are both connected to one end of the first connecting wire (108), and the other end of the first connecting wire (108) is used to connect to the skull pin; Visible light emitted by the organic light-emitting semiconductor (105) is used to excite the quantum dot film (103) to emit monochromatic far-red light that can penetrate biological tissue, thereby achieving non-invasive photogenetic regulation.

2. The space brain science animal experiment optogenetic device according to claim 1, characterized in that: The optogenetic component (1) further includes a peripheral component, wherein the peripheral component includes a first protective layer film (101) and a second protective layer film (107); The sensing layer film (102), the quantum dot film (103), and the OLED component are arranged between the first protective layer film (101) and the second protective layer film (107); The sensing layer film (102) is arranged close to the first protective layer film (101), and the OLED component is arranged close to the second protective layer film (107).

3. The space brain science animal experiment optogenetic device according to claim 2, characterized in that: The thin film circuit negative electrode (104) is arranged close to the quantum dot thin film (103), and the thin film circuit positive electrode (106) is arranged close to the second protective layer thin film (107).

4. The space brain science animal experiment optogenetic device according to claim 1, characterized in that: The transmitting and receiving component (2) includes a control and power supply component, a housing (210), and a fixing component (211); The control and power supply component is disposed in the housing (210), and the fixing component (211) is used to fix the housing (210) to the brain of an animal; The control and power supply component is electrically connected to the optogenetic component (1).

5. The space brain science animal experiment optogenetic device according to claim 4, characterized in that: The control and power supply component includes a power supply component (202) and a control module (203); The power supply component (202) is used to supply power to the control module (203); the optogenetic component (1) is connected to the control module (203) and the power supply component (202).

6. The optogenetic device for space brain science animal experiments according to claim 5, characterized in that: The power supply component (202) includes a wireless power supply module (206) and a second supplementary power source (207); The wireless power supply module (206) is used to supply power to the control module (203) and the optogenetic component (1), and the second supplementary power supply (207) is used to supply power to the control module (203).

7. The optogenetic device for space brain science animal experiments according to claim 5, characterized in that: The control module (203) includes a control circuit, a second connecting wire (201), a wireless communication module (204), a signal receiving and amplifying module (208), and a data temporary storage unit (205); One end of the second connecting wire (201) is used to connect to the skull pin, and the other end of the second connecting wire (201) is connected to the data temporary storage unit (205); The control circuit is connected to the data temporary storage unit (205) and the wireless communication module (204); Signal transmission is performed between the data temporary storage unit (205) and the signal receiving and amplifying module (208), and signal transmission is performed between the wireless communication module (204) and the main control unit; The power supply component (202) is used to supply power to the control circuit, the wireless communication module (204), the signal receiving and amplifying module (208), and the data temporary storage unit (205).

8. The space brain science animal experiment optogenetic device according to claim 4, characterized in that: The shell (210) is a polyetheretherketone shell, and the inner side of the polyetheretherketone shell is sprayed with a carbon fiber film layer (209).

9. The space brain science animal experiment optogenetic device according to claim 1, characterized in that: It also includes a control assembly (3), the control assembly (3) including a control box housing and a main control unit, the main control unit being arranged in the control box housing; The main control unit is used to adjust the optogenetic component (1) and the transmitting and receiving component (2).

10. The space brain science animal experiment optogenetic device according to claim 9, characterized in that: The control box housing is provided with a USB interface (302), a TypeC interface (303), a SCSI interface (304), an RS122 interface (3050), a short-distance wireless data transmission interface (306), an HD-SDI interface (307), an HDMI interface (308), a long-distance wireless data transmission port (309), a storage card interface (310), a situational fear module power interface (311), a Gigabit Ethernet interface (312), a 28V power supply interface (313), a suction water pipe interface (314), a 100V power supply interface (315), a sugar water preference module power interface (316), and a switch button (317) on one side wall thereof; A laser switch (318), a wireless control switch (319), a laser start indicator light (320), a touch screen manual control integrated switch (321), an air control switch (322), an air injection control button (323), an ammeter (324), an electric shock start indicator light (325), a water control switch (326), a water injection control button (327), and a water meter (328) are provided on one side wall of the control box housing. An air cooling interface (329) is provided on a peripheral side wall of the control box housing.

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