A method for increasing the content of linalool in honeysuckle dew

Abstract

The present invention provides a method for increasing the linalool content in honeysuckle dew, comprising the following steps: after screening the dust from the honeysuckle, placing it in a steam tank and spraying it with water, and draining the water after spraying; using a steam distillation method to distill the sprayed honeysuckle to obtain a linalool-containing liquid, wherein the distillation process parameters are: a steam pressure of 0.2MPa-0.4MPa and a distillate temperature of 28°C-48°C; filtering the liquid for the first time, adding auxiliary materials to the first filtrate, mixing evenly, filtering the mixed liquid for the second time, sterilizing the second filtrate, and cooling, thereby obtaining a honeysuckle dew with a high linalool content. The present invention adopts a steam distillation method, studies the steam pressure and the distillate temperature, and utilizes the mutual synergistic effect to obtain a linalool-containing liquid, and uses the liquid to prepare the honeysuckle dew, thereby further improving the product efficacy.

Description

Technical Field

[0001] The invention belongs to the field of linalool extraction, and particularly relates to a method for increasing the linalool content in honeysuckle dew. Background Art

[0002] Honeysuckle dew is mainly used clinically to clear away heat and detoxify. It is used to treat heatstroke, prickly heat, and furunculosis caused by summer heat invading the lungs and stomach, with symptoms of fever, thirst, sore throat, bright red prickly heat, and furunculosis on the head. At present, the main active ingredients of honeysuckle dew are volatile ingredients such as linalool. The existing extraction process of honeysuckle is imperfect, the active ingredients are not completely extracted, or volatilized and lost during the production process, resulting in a low content of linalool, which will ultimately directly affect the efficacy of the product.

[0003] Chinese patent CN111773261A discloses a production process of honeysuckle dew, which includes soaking honeysuckle with drinking water of 1 times the amount of drinking water for 30 minutes, controlling the steam pressure at 0.05-0.15Mpa, and when the water in the extraction tank boils, closing the steam valve, maintaining the pressure in the tank at 0.01-0.03Mpa, the temperature at 95℃-105℃, and collecting the distillate at a ratio of 1400mL of honeysuckle distillate for 100g of honeysuckle. Among them, immersion distillation will cause a great loss of volatile components such as linalool in the medicinal materials, because part of such components will remain in the water and cannot be completely extracted; the steam pressure is 0.05-0.15Mpa and 0.01-0.03Mpa, the overall pressure is relatively low, which will affect the distillation speed and increase the energy consumption in the industrial production process; and because it is immersion distillation, and the temperature in the tank is 95℃-105℃, the overall temperature of the liquid coming out will be too high, which will also cause losses to volatile components such as linalool. Summary of the invention

[0004] In view of this, the present invention provides a method for increasing the content of linalool in honeysuckle dew.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A method for increasing the linalool content in honeysuckle distillate comprises the following steps:

[0007] After screening the dust from the honeysuckle, place it in a steam tank and spray it with water, then drain the water after spraying;

[0008] The sprayed honeysuckle is distilled by steam distillation to obtain a liquid containing linalool, and the distillation process parameters are: steam pressure 0.2MPa-0.4MPa, distillate temperature 28°C-48°C.

[0009] Preferably, the process parameters of the steam distillation method are: steam pressure 0.25Mpa, distillate temperature 36°C.

[0010] Furthermore, the amount of water used for spraying is 1.5 times the mass of honeysuckle.

[0011] Furthermore, the mass of the distillate is 14 times that of honeysuckle, and the content of linalool in the distillate is 0.70 μg / mL to 0.85 μg / mL.

[0012] A honeysuckle dew is prepared by adding auxiliary materials to the honeysuckle distillate prepared by the above method.

[0013] Furthermore, the preparation process of honeysuckle dew includes the following steps: filtering the honeysuckle distillate for the first time, adding auxiliary materials to the first filtrate, mixing evenly, filtering the mixed solution for the second time, sterilizing the second filtrate, and cooling to obtain the product.

[0014] Furthermore, the first filtration uses a microporous filter membrane with a pore size of 50 μm, and the second filtration uses microporous filter membranes with pore sizes of 5 μm, 0.8 μm, and 0.45 μm, respectively.

[0015] Furthermore, the auxiliary materials include sucrose, citric acid and sodium benzoate.

[0016] Furthermore, the sterilization conditions are: temperature 130°C to 150°C, sterilization time 5 to 7s, and the cooling temperature is 83°C to 88°C.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] (1) The present invention adopts a steam distillation method, studies the steam pressure and the distillate temperature, and utilizes the synergistic effect to obtain a distillate with a high linalool content, wherein the linalool content in the final distillate is as high as 0.67 μg / mL to 0.85 μg / mL; the distillate is used to prepare honeysuckle dew, which can further increase the linalool content of the effective ingredient in the honeysuckle dew and enhance the product efficacy.

[0019] (2) The present invention adopts steam distillation, which is safer than organic solvent extraction; compared with supercritical extraction, the operation is simpler and the equipment requirements are low.

[0020] (3) The present invention does not soak and distill the honeysuckle medicinal material when using the steam distillation method, which has the advantages of the highest distillation efficiency and the lowest effective component loss rate compared with other distillation methods such as soaking distillation. The use of a higher steam pressure of 0.2MPa-0.4MPa can increase the distillation speed and save energy and reduce consumption. The liquid temperature is maintained at 28°C-48°C, and within this temperature range, the material loss of volatile components such as linalool extracted is minimized. DETAILED DESCRIPTION

[0021] The present invention is further described in detail below in conjunction with specific embodiments so that those skilled in the art can understand the present invention more clearly.

[0022] Sources and physical and chemical parameters of key test materials:

[0023] Honeysuckle was purchased from Shandong Zhongping Pharmaceutical Co., Ltd. and met the corresponding requirements of the Chinese Pharmacopoeia standards.

[0024] Other raw materials or structures not specifically described in the present invention already exist in the prior art and can be directly purchased from the market.

[0025] Example 1

[0026] This embodiment provides a method for increasing the linalool content in honeysuckle dew, and the specific operations are as follows:

[0027] S1. The honeysuckle medicinal materials are screened out of dust using an automatic wind selection line, and other impurities are selected through a medicine selection machine.

[0028] S2. Evenly spread the processed honeysuckle medicinal materials on the grate at the bottom of the steam tank through a feed distributor, open the top of the distillation tank to spray water on the medicinal materials (the amount of water used is 1.5 times the amount of medicinal materials), and after spraying, drain all the water from the bottom of the distillation tank, open the cooling water inlet and outlet valves, open the steam at the bottom of the distillation tank to start distillation, set the steam pressure to 0.25Mpa, maintain the distillate temperature at 36°C after cooling, and finally obtain a total amount of distillate that is 14 times the amount of honeysuckle medicinal materials.

[0029] S3. Filter the distillate obtained above into a batching tank through a 50 μm microporous filter membrane, add sucrose, citric acid and sodium benzoate, mix well, filter the mixture through 5 μm, 0.8 μm and 0.45 μm microporous filter membranes respectively, then sterilize at 140° C. for 6 seconds, cool to 85° C. and fill, to obtain honeysuckle dew with high linalool content.

[0030] Example 2

[0031] This embodiment provides a method for increasing the linalool content in honeysuckle dew, and the specific operations are as follows:

[0032] S1. The honeysuckle medicinal materials are screened out of dust using an automatic wind selection line, and other impurities are selected through a medicine selection machine.

[0033] S2. Evenly spread the processed honeysuckle medicinal materials on the grate at the bottom of the steam tank through a feed distributor, open the top of the distillation tank to spray the medicinal materials with water (the amount of water used is 1 times the amount of medicinal materials), and after spraying, drain all the water from the bottom of the distillation tank, open the cooling water inlet and outlet valves, open the steam at the bottom of the distillation tank to start distillation, set the steam pressure to 0.2Mpa, maintain the distillate temperature at 28°C after cooling, and finally obtain a total amount of distillate that is 14 times the amount of honeysuckle medicinal materials.

[0034] S3. Filter the distillate obtained above into a batching tank through a 50 μm microporous filter membrane, add sucrose, citric acid and sodium benzoate, mix well, filter the mixture through 5 μm, 0.8 μm and 0.45 μm microporous filter membranes respectively, then sterilize at 130° C. for 7 seconds, cool to 83° C. and fill, to obtain honeysuckle dew with high linalool content.

[0035] Example 3

[0036] This embodiment provides a method for increasing the linalool content in honeysuckle dew, and the specific operations are as follows:

[0037] S1. The honeysuckle medicinal materials are screened out of dust using an automatic wind selection line, and other impurities are selected through a medicine selection machine.

[0038] S2. Evenly spread the processed honeysuckle medicinal materials on the grate at the bottom of the steam tank through a feed distributor, open the top of the distillation tank to spray the medicinal materials with water (the amount of water used is twice the amount of medicinal materials), and after spraying, drain all the water from the bottom of the distillation tank, open the cooling water inlet and outlet valves, open the steam at the bottom of the distillation tank to start distillation, set the steam pressure to 0.4Mpa, maintain the distillate temperature at 48°C after cooling, and finally obtain a total amount of distillate that is 14 times the amount of honeysuckle medicinal materials.

[0039] S3. Filter the distillate obtained above into a batching tank through a 50 μm microporous filter membrane, add sucrose, citric acid and sodium benzoate, mix well, filter the mixture through 5 μm, 0.8 μm and 0.45 μm microporous filter membranes respectively, then sterilize at 150° C. for 5 seconds, cool to 88° C. and fill, to obtain honeysuckle dew with high linalool content.

[0040] In order to further study the effect of different distillation conditions on the linalool content in the final honeysuckle distillate, different steam pressures and distillate temperatures were tested. The test results are shown in the following table:

[0041] Table 1 Linalool content in distillates at different steam pressures and distillate temperatures

[0042]

[0043]

[0044] It can be seen from Table 1 that when the steam pressure is 0.2MPa~0.4Mpa and the liquid temperature is maintained at 28℃~48℃, the linalool content in the distillate is relatively high, and the content is higher than 0.70μg / mL.

[0045] Comparative Example 1

[0046] This comparative example provides a method for increasing the linalool content in honeysuckle dew, and its raw materials and steps are basically the same as those in Example 1, except that in step S2, the medicinal material is soaked in water twice the amount of the medicinal material for 30 minutes, and the leaching liquid is obtained by soaking distillation.

[0047] The linalool content in the final liquid was 0.35 μg / mL.

[0048] Other raw materials or structures not specifically described in the present invention already exist in the prior art and can be directly purchased from the market.

[0049] The above are only preferred embodiments of the present invention and are not intended to limit the protection scope of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A method for increasing the linalool content in honeysuckle distillate, characterized in that: The following steps are involved: After screening the dust from the honeysuckle, place it in a steam tank and spray it with water, then drain the water after spraying; The sprayed honeysuckle is distilled by steam distillation to obtain a distillate containing linalool, wherein the distillation process parameters are: steam pressure 0.2MPa-0.4MPa, distillate temperature 28°C-48°C; The amount of water used for spraying is 1 to 2 times the mass of honeysuckle; The mass of the distillate is 14 times that of honeysuckle, and the content of linalool in the distillate is 0.70 μg / mL to 0.85 μg / mL.

2. The method according to claim 1, characterized in that The process parameters of the steam distillation method are: steam pressure 0.25Mpa, distillate temperature 36°C.

3. A honeysuckle dew, characterized in that: The honeysuckle distillate prepared by the method of claim 1 or 2 is added with auxiliary materials to prepare the product.

4. The honeysuckle dew according to claim 3, characterized in that The preparation process comprises the following steps: filtering the honeysuckle distillate for the first time, adding auxiliary materials to the first filtrate, mixing evenly, filtering the mixed solution for the second time, sterilizing the second filtrate, and cooling to obtain the product.

5. The honeysuckle dew according to claim 4, characterized in that The first filtration uses a microporous filter membrane with a pore size of 50 μm, and the second filtration uses microporous filter membranes with pore sizes of 5 μm, 0.8 μm, and 0.45 μm, respectively.

6. The honeysuckle dew according to claim 4, characterized in that The auxiliary materials include sucrose, citric acid and sodium benzoate.

7. The honeysuckle dew according to claim 4, characterized in that The sterilization conditions are: temperature 130°C to 150°C, sterilization time 5 to 7s, and cooling temperature 83°C to 88°C.

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