A soothing composition, method of making and use thereof

Abstract

This application relates to the field of soothing product technology, specifically disclosing a soothing composition, its preparation method, and its application. A soothing composition comprises the following components in parts by weight: 1-1.5 parts dipotassium glycyrrhizate; 6-10 parts tetrahydromethylpyrimidine carboxylic acid; 2-4 parts *Tea oleifera* extract (from *Tea oleifera* var. *broomgrass*); deionized water, a chelating agent, and a humectant may also be introduced for synergistic use. The preparation method is as follows: the chelating agent and humectant are stirred and mixed evenly, heated to 45-55°C, then deionized water is added, stirred and mixed evenly, and cooled to 30-40°C to obtain a mixture; *Tea oleifera* extract is added to the mixture, stirred and mixed evenly, then dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid are added, and stirred and mixed evenly to obtain the final product. When used, the soothing composition of this application can enhance the soothing effect even if the concentrations of dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid exceed the upper limit, without causing any irritation to the human body.

Description

Technical Field

[0001] This application relates to the field of soothing product technology, and more specifically, to a soothing composition, its preparation method, and its application. Background Technology

[0002] In recent years, due to changes in people's skincare habits, such as overuse of cleansing products or excessive cleansing, increased environmental pollution, and increased mental stress, the incidence of sensitive skin has been increasing, reaching 32.4%-56%. As a result, soothing products have emerged to alleviate skin allergies and discomfort caused by factors such as climate change, ultraviolet rays, and pollution, soothe the skin, help adjust the skin condition, maintain the skin, and reduce the risk of skin inflammation.

[0003] Currently, using soothing and moisturizing skincare products, or combining them with medications and cosmetic treatments, can effectively alleviate the symptoms of sensitive skin. However, the ways and manifestations of allergies vary among individuals, and a single soothing and moisturizing skincare product cannot comprehensively relieve allergy symptoms. Dipotassium glycyrrhizate has multiple effects such as anti-inflammatory, anti-allergic, antibacterial, and antioxidant properties. It can be used for sun protection, assisting in whitening, relieving itching, regulating sebum, and promoting hair growth and health, making it a good anti-allergy additive. Tetrahydromethylpyrimidine carboxylic acid is a good skin conditioning agent that can stabilize the structure of enzyme proteins in organisms and has moisturizing, skin repair, anti-aging, anti-inflammatory, and anti-radiation effects. Therefore, dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid are often used in soothing products to achieve excellent soothing effects. However, to achieve better soothing effects, high concentrations should not be added. This is because when the amount of dipotassium glycyrrhizate in the formula reaches 1% and the amount of tetrahydromethylpyrimidine carboxylic acid reaches 6%, it not only fails to have a soothing effect but also causes slight irritation to the human body. Moreover, exceeding the above-mentioned amounts makes the irritation more obvious, resulting in poor suitability for sensitive individuals.

[0004] Therefore, there is an urgent need to propose a solution to address the aforementioned technical problems. Summary of the Invention

[0005] In order to increase the upper limit of the dosage of dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid in soothing products, so as to provide a strong soothing effect without irritating the human body and making it more suitable for sensitive people, this application provides a soothing composition, its preparation method and application.

[0006] In a first aspect, this application provides a soothing composition, employing the following technical solution:

[0007] A soothing composition comprising the following components in parts by weight:

[0008] Dipotassium glycyrrhizate 1-1.5 parts;

[0009] 6-10 parts of tetrahydromethylpyrimidine carboxylic acid;

[0010] 2-4 parts of broom leaf Australian tea extract.

[0011] By employing the above-mentioned technical solutions, dipotassium glycyrrhizate achieves the elimination of inflammation and allergic reactions by inhibiting hyaluronidase activity, histamine release, and the production of leukotrienes (LTs) and prostaglandin E2. The cyclic structure of tetrahydromethylpyrimidine carboxylic acid molecules has strong electronegativity, forming hydrogen bonds with water molecules to alter their spatial distribution, causing them to align and promoting water molecule association. This leads to the formation of more water molecule clusters, resulting in a hydration layer around the protein. The presence of this insulating layer blocks / reduces external stimulation to skin cells, giving them better resilience and alleviating adverse reaction symptoms. Both components exhibit good soothing effects at low concentrations, but as the concentration increases to a certain level, the soothing effect does not increase accordingly and may even cause some irritation to the body. The combination of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract, through the neutralization and regulation of the three ingredients, can enhance the soothing effect even when the concentrations of dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid exceed the upper limit, without causing any irritation to the human body, making it highly suitable for sensitive individuals.

[0012] Preferably, the weight ratio of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract is 1.3:8.5:3.

[0013] By adopting the above technical solution, the combined effect of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid and broom leaf Australian tea extract at the above weight ratio is excellent. Even when the concentrations of dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid are high, their combination can still achieve excellent soothing effects without causing any irritation to the human body, making it more suitable for sensitive individuals.

[0014] Preferably, the soothing composition comprises the following components in parts by weight percentage:

[0015] Chelating agent 0.3-0.7%;

[0016] Moisturizer 0.3-0.7%;

[0017] Dipotassium glycyrrhizate 1-1.5%;

[0018] Tetrahydromethylpyrimidine carboxylic acid 6-10%;

[0019] 2-4% broom leaf Australian tea extract;

[0020] Deionized water 80-90%.

[0021] By employing the above-mentioned technical solution, the use of water, chelating agents, and moisturizers enables dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract to be mixed evenly and stably applied to human skin, thereby achieving excellent soothing effects without causing irritation to the human body. Furthermore, when introducing other raw materials to form a soothing product as needed, it is only necessary to replace some of the deionized water with the corresponding weight parts of the required raw materials, while the other components in the soothing composition can fully combine with the introduced raw materials to obtain the desired product of excellent quality.

[0022] Preferably, the chelating agent is one or a combination of several of p-hydroxyacetophenone, disodium EDTA, sodium tripolyphosphate, and aminotriacetic acid.

[0023] By adopting the above technical solutions, the above-mentioned chelating agents all have good dispersion and suspension effects. In the application process, they can assist dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid and broom leaf Australian tea extract to fully cooperate. The resulting soothing composition not only has excellent soothing effects, but also does not produce any irritation to the human body, and has better overall quality.

[0024] Preferably, the humectant is one or a combination of several of 1,2-hexanediol, mannitol, propylene glycol and sorbitol.

[0025] By adopting the above-mentioned technical solution, the above-mentioned moisturizers have excellent and stable dispersibility and binding properties with other component raw materials, so that the components in the soothing composition can be combined with other raw materials to obtain a high-quality soothing product that can exert a strong soothing effect without irritating the human body.

[0026] Preferably, the soothing composition comprises the following components in parts by weight percentage:

[0027] p-Hydroxyacetophenone 0.3-0.7%;

[0028] 1,2-Hexanediol 0.3-0.7%;

[0029] Dipotassium glycyrrhizate 1-1.5%;

[0030] Tetrahydromethylpyrimidine carboxylic acid 6-10%;

[0031] 2-4% broom leaf Australian tea extract;

[0032] Deionized water 80-90%.

[0033] By adopting the above technical solution, the soothing composition composed of the above raw materials has a better and more stable effect when the soothing product is obtained by replacing some of the deionized water with other raw materials. Even if the content of dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid is high, it will not cause irritation to the human body, and the soothing effect is also stronger.

[0034] Secondly, this application provides a method for preparing a soothing composition, using the following technical solution:

[0035] A method for preparing a soothing composition includes the following steps:

[0036] (1) Prepare the raw materials containing chelating agent, moisturizer, dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, broom leaf Australian tea extract and deionized water according to the formula;

[0037] (2) Stir and mix the chelating agent and moisturizer in step (1) until they are evenly mixed. During the process, heat the mixture to 45-55°C, then add deionized water, stir and mix until evenly mixed, and cool the mixture to 30-40°C to obtain a mixture.

[0038] (3) Add broom leaf Australian tea extract to the mixture in step (2), stir and mix evenly, then add dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid, stir and mix evenly to obtain the soothing composition.

[0039] By adopting the above technical solution, the overall operation is relatively simple and convenient in the preparation process of the soothing composition, and it can fully mix the raw materials of each component and form a uniform and stable mixture, thereby exerting excellent efficacy in the application process and making the obtained soothing composition have excellent quality.

[0040] Thirdly, this application provides an application of a soothing composition in a soothing product, employing the following technical solution:

[0041] The use of a soothing composition in soothing products, said soothing products including facial cleansers, bath gels, shampoos, lotions, perfumes, cleansing waters, makeup removers, and serums.

[0042] By adopting the above technical solutions, the soothing composition can be used in all of the above products. While exerting a high soothing effect, it will not irritate the human body, and its overall application is quite wide.

[0043] In summary, this application has the following beneficial effects:

[0044] This application uses a compound of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract as a soothing composition. When the amount of dipotassium glycyrrhizate added to the formula reaches or exceeds 1%, and the amount of tetrahydromethylpyrimidine carboxylic acid added reaches or exceeds 6%, it can also bring about an enhanced soothing effect without causing any irritation to the human body, and has excellent suitability for sensitive people. Detailed Implementation

[0045] The present application will be further described in detail below with reference to the embodiments.

[0046] Unless otherwise specified, all raw materials used in the preparation examples and embodiments of this application are commercially available.

[0047] p-Hydroxyacetophenone was purchased from Symrise's GeniusCare HAP.

[0048] 1,2-Hexanediol was purchased from Cosphatec GmbH;

[0049] Dipotassium glycyrrhizate was purchased from Pan-Plant Corporation.

[0050] Tetrahydromethylpyrimidine carboxylic acid was purchased from Blue Crystal Company's ectoine.

[0051] The broom leaf extract was purchased from Ganesha's broom leaf extract (LEPTOSPERMUM SCOPARIUM).

[0052] Purslane extract was purchased from Shanghai Huiwen Biotechnology Co., Ltd.

[0053] Citrus reticulata fruit extract was purchased from GREAF Biotechnology's Calmnerv product. TM CR;

[0054] Panthenol was purchased from DSM's D-panthenol;

[0055] C10-18 fatty acid triglycerides were purchased from GELEOL PELLETS, GATTEFOOSSE.

[0056] Behenyl alcohol was purchased from BASF;

[0057] Oil-soluble silicone was purchased from Momentive Silsoft 034;

[0058] Glycerin was purchased from Procter & Gamble.

[0059] The thickener was purchased from BASF Cosmdia SP.

[0060] Example

[0061] Example 1

[0062] A soothing composition, the components of which and their corresponding weights are shown in Table 1, is prepared by the following steps:

[0063] (1) Prepare raw materials containing dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid and broom leaf Australian tea extract according to the formula;

[0064] (2) Mix dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid and broom leaf Australian tea extract from step (1) evenly, stir at 300r / min for 30min, and mix at 35℃ to obtain the soothing composition.

[0065] Example 2-10

[0066] A soothing composition differs from that of Example 1 in that its component ingredients and their corresponding weights are shown in Table 1.

[0067] Table 1. Raw materials and their weight parts (kg / part) for each component in Examples 1-10

[0068]

[0069] Example 11

[0070] A soothing composition, differing from Example 1 in that it is produced using 100 kg as the production standard, and its component raw materials and their corresponding weight percentages are shown in Table 2, and is prepared by the following steps:

[0071] (1) Prepare the raw materials containing chelating agent, moisturizer, dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, broom leaf Australian tea extract and deionized water according to the formula;

[0072] (2) Stir the chelating agent and moisturizer in step (1) until they are evenly mixed. Stir at 300r / min for 10min, and heat to 45-55℃ during the process. Then add deionized water, stir for 5min until they are evenly mixed, and cool to 30-40℃ to obtain a mixture.

[0073] (3) Add broom leaf Australian tea extract to the mixture in step (2), stir at 300 r / min for 10 min, stir until evenly mixed, then add dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid, stir at 300 r / min for 15 min, stir until evenly mixed, and the soothing composition can be obtained.

[0074] Note: The chelating agent is p-hydroxyacetophenone, and the humectant is 1,2-hexanediol; the heating temperature in step (2) is 50°C, and the temperature is reduced to 35°C.

[0075] Examples 12-15

[0076] A soothing composition differs from that of Example 11 in that its component ingredients and their corresponding weight percentages are shown in Table 2.

[0077] Table 2. Raw materials and their weight percentages (%) for each component in Examples 11-15

[0078]

[0079] Example 16

[0080] A soothing composition, which differs from Example 11 in that the chelating agent is disodium EDTA.

[0081] Example 17

[0082] A soothing composition, differing from that of Example 11, wherein the chelating agent is a composition of sodium tripolyphosphate and nitric acid in a weight ratio of 1:1.

[0083] Example 18

[0084] A soothing composition, which differs from Example 11 in that the moisturizer is mannitol.

[0085] Example 19

[0086] A soothing composition, differing from that of Example 11, wherein the moisturizer is a composition of propylene glycol and sorbitol in a weight ratio of 1:1.

[0087] Example 20

[0088] A repair cream, the raw materials of which are shown in Table 3 and their corresponding weight percentages, is prepared by the following steps: (1) Prepare raw materials containing p-hydroxyacetophenone, 1,2-hexanediol, dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, broom leaf Australian tea extract, thickener, glycerin, oil-soluble organosilicon, behenol, C10-18 fatty acid triglycerides and deionized water according to the formula;

[0089] (2) Mix the hydroxyacetophenone, 1,2-hexanediol, glycerol, thickener and deionized water in step (1) evenly, stir at 300 r / min for 10 min, heat to 80℃ during the process, and stir until completely dissolved;

[0090] (3) Heat the oil-soluble organosilicon, behenol, and C10-18 fatty acid triglycerides in step (1) to 80°C and stir until completely dissolved;

[0091] (4) Add the mixture from step (3) to the mixture from step (2), homogenize at 60,000 r / min for 5 min, then cool to 40°C, add broom leaf Australian tea extract, dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid, stir at 300 r / min for 15 min, stir and mix evenly to obtain the repair cream.

[0092] Examples 21-23

[0093] A repair cream differs from Example 11 in that its component ingredients and their corresponding weight percentages are shown in Table 3.

[0094] Table 3. Raw materials and their weight percentages (%) for each component in Examples 20-23

[0095]

[0096] Comparative Example

[0097] Comparative Examples 1-12

[0098] A soothing composition differs from that of Example 1 in that its component ingredients and their corresponding weights are shown in Table 4.

[0099] Table 4. Raw materials and their weight parts (kg / part) for Comparative Examples 1-12

[0100]

[0101] Comparative Example 13

[0102] A soothing composition, differing from Example 1 in that the broom leaf Australian tea extract and other ingredients are replaced by purslane extract.

[0103] Comparative Example 14

[0104] A soothing composition, differing from Example 1 in that the broom leaf Australian tea extract and other ingredients are replaced by citrus fruit extract.

[0105] Comparative Example 15

[0106] A soothing composition, differing from Example 1 in that the amount of broom leaf Australian tea extract is replaced with panthenol.

[0107] Comparative Example 16

[0108] A soothing composition, which differs from Example 1 in that it does not contain broom leaf Australian tea extract.

[0109] Performance testing test samples: The soothing compositions obtained in Examples 1-10 were used as test samples 1-10, with deionized water added to a final volume of 100 kg; the soothing compositions obtained in Examples 11-19 were used as test samples 11-19; the repair cream obtained in Examples 20-23 was used as test samples 20-23; and the soothing compositions obtained in Comparative Examples 1-16 were used as control samples 1-16, with deionized water added to a final volume of 100 kg.

[0110] Test method:

[0111] Preset sample: a) Dipotassium glycyrrhizate aqueous solution with a concentration of 1%;

[0112] b. The concentration of dipotassium glycyrrhizate aqueous solution is 1.5%;

[0113] c. The aqueous solution concentration of tetrahydromethylpyrimidine carboxylic acid is 0.9%;

[0114] d. The concentration of the aqueous solution of tetrahydromethylpyrimidine carboxylic acid is 6%;

[0115] e. The aqueous solution concentration of tetrahydromethylpyrimidine carboxylic acid is 10%;

[0116] f. The concentration of tetrahydromethylpyrimidine carboxylic acid in aqueous solution is 5.9%;

[0117] Participant selection criteria: ① Inclusion criteria: 30 healthy participants aged 18–50 years who strictly adhered to the experimental requirements and signed the informed consent form. ② Exclusion criteria: Pregnant or breastfeeding women; those at risk of allergies or high sensitivity to personal care products; those with acute inflammation, immunodeficiency, or other skin diseases at the test site. ③ Withdrawal criteria: Participants who voluntarily withdrew during the experiment, exhibited poor compliance, had pregnancy, experienced adverse reactions, were lost to follow-up, or had other special circumstances requiring withdrawal from the experiment.

[0118] (1) Human skin patch test (closed skin patch test): 0.02 ml of sample was placed in the patch tester and applied to the back of the subject with low-sensitivity adhesive. The test substance was removed after 24 hours. The skin reaction was observed 24 hours after removal. The results were recorded according to the skin grading standard in the "Cosmetic Safety Technical Specifications" (2015 edition). The average value was taken according to the corresponding score level and recorded in Table 5. The above samples were tested in sequence.

[0119]

[0120] (2) Hyaluronidase inhibition rate test: Because sensitive skin is characterized by impaired barrier function or abnormal nerve conduction, it has a weaker defense against exogenous irritants and allergens compared to normal skin. Therefore, sensitive skin is prone to a series of inflammatory reactions caused by irritation or allergies. The inflammatory reaction further damages the skin barrier structure and nerve endings, leading to a vicious cycle. Hyaluronidase is involved in type I hypersensitivity reactions and has a strong correlation with inflammation and allergies. Hyaluronic acid can inhibit inflammatory reactions. Hyaluronidase is a specific cleavage enzyme of hyaluronic acid. Inhibiting the activity of hyaluronidase can ensure the normal content and function of hyaluronic acid. Therefore, the hyaluronidase inhibition rate can be used as an indicator to evaluate the anti-inflammatory activity of a substance. The higher the hyaluronic acid inhibition rate, the stronger the anti-inflammatory activity. Inhibiting hyaluronidase can reduce the damage to the skin barrier structure and nerve endings caused by skin inflammation, thus having a soothing effect.

[0121] The soothing efficacy of a product is evaluated by testing its inhibition rate of hyaluronidase.

[0122] Instruments and reagents: Microplate reader (BioTek), analytical balance (Shimadzu), pipette (Beijing Dalong), hyaluronidase (Maclean), sodium hyaluronate (Maclean), PBS buffer (BioSharp), sodium cromoglycate (Maclean), CTAB (Maclean)

[0123] Ambient temperature: 20-25℃, humidity: 50-60% RH

[0124] Hyaluronidase inhibition rate: Mix 200 μL each of sample solution, hyaluronidase solution, and sodium hyaluronate, and incubate at 37℃ for 20 min; add 200 μL of CTAB solution; pipette 200 μL of each reaction solution into a 96-well microplate and measure the absorbance at 600 nm. Calculate the effect of the sample on hyaluronidase activity and calculate the statistically significant p-value.

[0125] References

[0126] Wang Huan, Pan Yao. Evaluation of Cosmetic Efficacy (V) – Scientific Support for Claims of Soothing Effects. Daily Chemical Industry, Vol. 48, No. 5

[0127] Cheng, Shujun. Implementation Guidelines for Alternative Methods for Cosmetic Evaluation. China Standards Press, 2017.3.

[0128] Chen Jianping, Luo Chenyang, Zhong Saiyi, Qin Xiaoming. Study on the anti-allergic effect of bromelain. Agricultural Product Processing. No. 11 (Total No. 420), November 2016.

[0129] (3) Detection of inflammatory factors in the YDJC-SOP-050LPS-induced macrophage inflammation model: The in vitro inflammation model of macrophages induced by lipopolysaccharide (LPS) was used to evaluate the soothing effect of the test substance by detecting the concentration of IL-8.

[0130] The soothing efficacy of the test product was evaluated by measuring the IL-8 content (pg / mL) in a cell model.

[0131] Instruments and reagents: Microplate reader (BioTek), analytical balance (Shimadzu), pipette (Beijing Dalong)

[0132] Cell line: Macrophages (RAW264.7) (CyberKang (Shanghai) Biotechnology Co., Ltd.)

[0133] Culture medium: DMEM medium (Thermo Fisher Scientific) containing 10% FBS (Shanghai Dalsh Biotechnology).

[0134] Experimental reagent kits: CCK-8 kit (Solarbio), IL-8 kit (Xinquan Technology)

[0135] Environmental conditions: Temperature 18-27℃, Humidity 30-70% RH

[0136] Culture conditions: 37℃, 5% CO2 2 Cultivation under saturated humidity conditions

[0137] Test methods

[0138] (1) Cell viability test

[0139] 1. Seed the cell suspension (100 μL / well) into 96-well plates. Pre-culture the plates in an incubator.

[0140] 2. Add 10 μL of CCK-8 solution to each well.

[0141] 3. Incubate the culture plate in an incubator for 2 hours.

[0142] 4. Measure the absorbance at 450 nm using an ELISA reader.

[0143] Cell viability was calculated by taking the cell viability of the blank control group as 100% and calculating the relative cell viability of each group.

[0144] Relative cell viability (%) = [(OD sample - OD blank) / (OD control - OD blank)] × 100%.

[0145] Result determination: Relative activity ≤ 50% indicates irritation; relative activity > 50% indicates no irritation.

[0146] (2) IL-8 content determination

[0147] 1. Seed macrophages (RAW264.7) into 96-well plates and culture for 18-24 hours.

[0148] 2. Replace the blank group with maintenance culture medium, and incubate the other groups with maintenance culture medium containing samples or positive controls for 48 hours.

[0149] 3. Discard the original culture medium, wash 3 times with PBS, and add serum-free DMEM culture medium to the blank control group.

[0150] 4. The remaining groups were given culture medium containing 500 ng / ml LPS and stimulated for 1 hour to induce an inflammation model.

[0151] 5. Collect the cell supernatant and detect the IL-8 content according to the kit instructions.

[0152] Table 5. Test results of pre-set samples, test samples 1-23 and control samples 1-16

[0153]

[0154]

[0155]

[0156] Based on Examples 1 and Comparative Examples 13-16, and in conjunction with Table 2, it can be seen that when dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract are combined as a soothing composition, a strong soothing effect can still be achieved even when the content of dipotassium glycyrrhizate exceeds 1% and the amount of tetrahydromethylpyrimidine carboxylic acid exceeds 6%, without causing irritation to the human body. However, when the broom leaf Australian tea extract is replaced with purslane extract, citrus fruit extract, and panthenol, it is found that none of them can eliminate the irritating effect caused by excessive dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid, and the soothing effect of the resulting composition is relatively poor.

[0157] Based on Examples 1-10 and Comparative Examples 1-12, and referring to Table 2, it can be seen that when the weight ratio of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract is (1-1.5):(6-10):(2-4), and when the amount of dipotassium glycyrrhizate added to the formula reaches or exceeds 1%, and the amount of tetrahydromethylpyrimidine carboxylic acid added reaches or exceeds 6%, the soothing composition can exert a strong soothing effect without causing irritation. Otherwise, even with the combination of broom leaf Australian tea extract with dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid, it is difficult to achieve a non-irritating effect. Furthermore, in the combination of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract, it can be found that when the weight ratio of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract is 1.3:8.5:3, the soothing composition not only has no irritation to the human body but also provides excellent soothing effects.

[0158] As can be seen from Examples 1 and 11-15 and Table 2, the introduction of water, chelating agents, and humectants into the combination of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract in this application enhances the soothing effect of the composition on human skin, resulting in a stronger overall soothing effect. Furthermore, when the weight ratio of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract is 1.3:8.5:3,

[0159] As can be seen from Examples 1 and 20-23 and Table 2, when other component raw materials are introduced to form a soothing product according to the needs, it is only necessary to replace part of the deionized water with the required raw materials in the corresponding weight parts. The resulting repair cream is not only non-irritating to the human body, but also has a superior soothing effect, thus enabling the application of the soothing composition to bring stable effects.

[0160] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A soothing composition, characterized in that, It contains the following components by weight percentage: p-Hydroxyacetophenone 0.3-0.7%; 1,2-Hexanediol 0.3-0.7%; Dipotassium glycyrrhizate 1-1.5%; Tetrahydromethylpyrimidine carboxylic acid 6-10%; 2-4% of broom leaf Australian tea extract; Deionized water 80-90%.

2. The soothing composition according to claim 1, characterized in that: The weight ratio of dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, and broom leaf Australian tea extract is 1.3:8.5:

3.

3. The method for preparing the soothing composition according to claim 1, characterized in that: Includes the following steps: (1) Prepare the raw materials containing p-hydroxyacetophenone, 1,2-hexanediol, dipotassium glycyrrhizate, tetrahydromethylpyrimidine carboxylic acid, broom leaf Australian tea extract and deionized water according to the formula; (2) Stir and mix p-hydroxyacetophenone and 1,2-hexanediol in step (1) until homogeneous. Heat the mixture to 45-55°C during the process, then add deionized water and stir until homogeneous. Cool the mixture to 30-40°C to obtain a mixture. (3) Add broom leaf Australian tea extract to the mixture in step (2), stir and mix evenly, then add dipotassium glycyrrhizate and tetrahydromethylpyrimidine carboxylic acid, stir and mix evenly to obtain the soothing composition.

4. The use of the soothing composition according to any one of claims 1-2 in the preparation of soothing products, characterized in that: The soothing products include facial cleansers, bath gels, shampoos, toners, perfumes, cleansing waters, makeup removers, and serums.

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