A Soothing and Moisturizing Special Skin Care Lotion and Its Preparation Method

Abstract

The invention discloses a soothing and moisturizing skin care lotion, which is composed of the following raw materials by weight: 10-15 parts of a moisturizing agent, 3-8 parts of an emulsifier, 2-4 parts of a surfactant, 10-15 parts of a skin care agent, 0.1-1 parts of an antioxidant, 5-9 parts of a softener, 5-10 parts of an adjuvant, 0.01-0.05 parts of p-hydroxyacetophenone, 0.2-0.5 parts of a surfactant, 3-6 parts of a carbomer, 4-8 parts of a modified composite carrier, 5-8 parts of a ceramide complex, and 30-45 parts of water. The soothing and moisturizing skin care lotion has a unique formula, obvious moisturizing and hydrating effects, and a refreshing and non-greasy feel. Through the combined action of various substances, the prepared special care lotion has multiple functions such as scavenging free radicals, removing wrinkles and brightening the skin tone, and delaying skin aging.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care products, and particularly relates to a soothing and moisturizing skin care lotion and a preparation method thereof. Background Art

[0002] The skin's physical barrier is composed of the sebum membrane, keratin in the stratum corneum, lipids, a "sandwich" structure, a brick wall structure, dermal mucopolysaccharides, and mucopolysaccharides. It has the function of resisting the entry of harmful external substances, irritants, and ultraviolet rays, while also having moisturizing, regulating, anti-inflammatory, and anti-aging effects.

[0003] With global climate and ecological changes, harmful airborne substances such as inhalable particulate matter, sulfur dioxide, nitrogen oxides, carbon monoxide, and ozone not only harm human respiratory health but can also easily cause facial redness, swelling, and allergies. This is due to the loss of moisture from the skin's surface layer, which can lead to dryness, scaling, or itching. At this time, harmful airborne substances, surface pathogens, pollen, and other allergens can easily penetrate the damaged skin barrier and enter the skin, triggering further skin inflammation. To improve their appearance and enhance their beauty, cosmetics have become a daily necessity. In particular, cosmetics with functional properties such as acne treatment, whitening, moisturizing, sun protection, and anti-aging have gradually become a popular choice.

[0004] Skin care creams and cosmetics, particularly functional skin care products, have become indispensable daily necessities. Cosmetics production technology continues to innovate, and products are constantly being upgraded. Cosmetics have evolved from their original, unprocessed natural products to chemically synthesized ones. Now, people are enthusiastic about products that are natural, green, additive-free, and free of artificial colors and synthetic fragrances. Consumers are returning to nature, and people are placing greater emphasis on their quality of life and health, driving continuous advancements in cosmetics technology. However, anti-pollution cosmetics are scarce on the market. Coupled with the effects of external factors such as sunburn and post-surgery, protecting and repairing damaged skin has become a growing concern. Current treatments for skin allergies and damage repair primarily involve medications containing antihistamines or hormones, which only provide temporary relief but fail to fundamentally address the problem.

[0005] In the prior art, Chinese patent application No. 202010456706.4 discloses a ceramide compound skin-soothing and repairing factor and its emulsion. The repairing factor is composed of the following components by weight: 112-19 parts of ceramide, 8-11 parts of seaweed extract, 5-7 parts of coix seed extract, 4-6 parts of Centella asiatica extract, 3-6 parts of Patchouli extract, 3-6 parts of Scutellaria root extract, 2-4 parts of Andrographis paniculata extract, 1-3 parts of camellia sinensis extract fermentation product, 1-2 parts of tea seed oil, 1-3 parts of avocado oil, 1-2 parts of calendula flower oil, 1-1.2 parts of scutellaria baicalensis flower oil, 2-4 parts of myrtle seed extract, and 1-2 parts of mung bean seed extract. This repairing factor is non-irritating to the skin and can effectively soothe damaged skin, regulate the skin's water and oil balance system, and effectively repair the damaged skin barrier. The emulsion has strong permeability, effectively repairs the skin barrier, and protects against external irritants. Although it can effectively protect the skin, it also has the disadvantages of insufficient protection duration and insufficient ability to moisturize the skin after use.

[0006] Therefore, there is an urgent need in this field to develop a soothing and moisturizing skin care lotion that has the effects of soothing the skin, repairing the skin barrier, improving skin tolerance, etc., and can lock in moisture for a long time. Summary of the Invention

[0007] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide a soothing and moisturizing skin care lotion and a preparation method thereof. The special care lotion has the effects of soothing the skin, repairing the skin barrier, and improving skin tolerance, and can also moisturize, increase skin elasticity, improve antioxidant and delay skin aging.

[0008] To achieve the above object, the present invention provides the following technical solutions:

[0009] A soothing and moisturizing skin care lotion, composed of the following raw materials in parts by weight:

[0010] 10-15 parts of moisturizer, 3-8 parts of emulsifier, 2-4 parts of surfactant, 10-15 parts of skin care agent, 0.1-1 part of antioxidant, 5-9 parts of emollient, 5-10 parts of auxiliary agent, 0.01-0.05 parts of p-hydroxyacetophenone, 0.2-0.5 parts of surfactant auxiliary agent, 3-6 parts of carbomer, 4-8 parts of modified composite carrier, 5-8 parts of ceramide complex, and 30-45 parts of water.

[0011] Preferably, a soothing and moisturizing skin care lotion is composed of the following raw materials in parts by weight:

[0012] 13 parts of moisturizer, 7 parts of emulsifier, 3 parts of surfactant, 12 parts of skin care agent, 0.5 parts of antioxidant, 7 parts of emollient, 8 parts of auxiliary agent, 0.03 parts of p-hydroxyacetophenone, 0.4 parts of surfactant auxiliary agent, 5 parts of carbomer, 6 parts of modified composite carrier, 7 parts of ceramide complex, and 37 parts of water.

[0013] Preferably, the moisturizer is a mixture of glycerin, sodium hyaluronate, butylene glycol, 1,2-hexanediol and panthenol, and the mass ratio thereof is 100:2-5:10-15:30-40:10-20; the emulsifier is cetearyl alcohol; the surfactant is a mixture of hydrogenated lecithin, glyceryl stearate, cetearyl olive oil ester and sodium stearoyl lactylate, and the mass ratio thereof is 10:10-20:15-20:5-10; the skin care agent is a mixture of meadowfoam seed oil, purslane extract, ginger root extract, Bacillus / soybean fermentation product extract and xanthan gum aqueous solution, and the mass ratio thereof is 80:10-20:5-10:10-15:10-20, and the mass concentration of the xanthan gum aqueous solution is 5-10%; the antioxidant is a mixture of tocopherol and tocopherol acetate, and the mass ratio thereof is 1:1-3.

[0014] Preferably, the emollient is a mixture of butylene glycol dicaprylate / dicaprate and dicaprylyl carbonate in a mass ratio of 10:5-20; the adjuvant is a mixture of β-glucan, allantoin, arginine, bisabolol and folic acid in a mass ratio of 50:2-5:0.5-2:10-15:0.1-0.5; the surfactant is a mixture of sorbitan olivate and acetyl glucosamine in a mass ratio of 5:3-8; the ceramide complex is a mixture of ceramide NP, ceramide EOP, ceramide AS and ceramide AP in a mass ratio of 20:1-2:0.1-0.3:0.5-1.

[0015] Preferably, the method for preparing the modified composite carrier comprises the following steps:

[0016] (a) diatomaceous earth is soaked in dilute hydrochloric acid, filtered, washed, and dried to obtain pretreated diatomaceous earth, then the pretreated diatomaceous earth is added to a sodium hydroxide solution, followed by addition of microcrystalline cellulose and urea, stirred evenly, and then ultrasonically treated to obtain a mixed solution, then the mixed solution is added to a mixed solvent of ethyl acetate and acetic acid, stirred, allowed to stand, washed with water, and freeze-dried to obtain a cellulose / diatomaceous earth composite; the cellulose / diatomaceous earth composite is placed in a muffle furnace for calcination, and after calcination, ground to obtain a modified diatomaceous earth powder;

[0017] (b) adding aqueous ammonia to anhydrous ethanol to obtain a mixed solution, adding the modified diatomaceous earth powder in step (a) to the mixed solution, then adding tetraethyl orthosilicate dropwise under stirring to carry out a hydrothermal reaction, and after the reaction is completed, filtering, drying, and washing to obtain a silicon dioxide / modified diatomaceous earth powder;

[0018] (c) dissolving superoxide dismutase in deionized water to obtain an enzyme solution, and then impregnating the silica / modified diatomaceous earth powder obtained in step (b) into the enzyme solution. After impregnation, the mixture is filtered, freeze-dried, ground, and passed through a 300-mesh sieve to obtain the modified composite carrier.

[0019] Preferably, the mass concentration of the dilute hydrochloric acid in step (a) is 10-15%; the soaking time is 2-3 hours; the mass concentration of the sodium hydroxide is 5-10%; the mass ratio of the pretreated diatomaceous earth, sodium hydroxide solution, microcrystalline cellulose, and urea is 30:100-120:5-10:10-15; the mass fraction of ethyl acetate in the mixed solvent of ethyl acetate and acetic acid is 40-60%; the calcination temperature is 600-750°C and the time is 3-5 hours.

[0020] Preferably, the mass concentration of the ammonia water in step (b) is 15-20%; the mass ratio of the modified diatomaceous earth powder, ammonia water, anhydrous ethanol, and tetraethyl orthosilicate is 30:5-10:120-140:10-15; the temperature of the hydrothermal reaction is 100-130°C, and the reaction time is 2-4h.

[0021] Preferably, the concentration of superoxide dismutase in the enzyme solution in step (c) is 2-4 g / L; the immersion temperature is 15-25° C., and the immersion time is 5-10 h.

[0022] The present invention also provides a method for preparing the soothing and moisturizing skin care lotion, comprising the following steps:

[0023] (1) Add a skin care agent, a softener, 1.5-4 parts of an emulsifier, and 5-8 parts of a moisturizer into an oil phase pot, and stir and mix uniformly at 75-85° C. to obtain material A;

[0024] (2) adding water, surfactant, antioxidant, auxiliary agent, surfactant auxiliary agent and the remaining emulsifier and moisturizer into the water phase pot, stirring and mixing at 70-80° C., then pumping into the homogenization emulsification pot, slowly adding the material A in step (1) into the emulsification pot under stirring conditions, homogenizing and emulsifying, vacuum degassing after the emulsification is completed, cooling, and obtaining material B;

[0025] (3) When the material B in step (2) is cooled to 30-36° C., p-hydroxyacetophenone, carbomer, ceramide complex and modified composite carrier are added to perform secondary homogenization and emulsification. After the emulsification is completed, vacuum degassing is performed and the material is cooled to room temperature to obtain the soothing and moisturizing skin care lotion.

[0026] Preferably, the homogenization emulsification conditions in step (2) are a stirring speed of 1500-2000 r / min and a time of 10-15 min; the secondary homogenization emulsification conditions in step (3) are 800-1200 r / min and a time of 5-10 min.

[0027] In the present invention, 1,2-hexanediol has good skin moisturizing effect, excellent broad-spectrum antibacterial activity, high purity, low odor, high safety, and is particularly suitable for sensitive and delicate skin.

[0028] Panthenol: In skin care products, it can improve and increase skin moisture, making dry skin softer and more elastic. In addition, it can soothe irritated skin and play an anti-inflammatory role.

[0029] Cetearyl Alcohol: Emulsifier and thickener, it can increase the stability of the emulsion and has a co-emulsifying effect.

[0030] Hydrogenated lecithin, glyceryl stearate, cetearyl olivate, and sodium stearoyl lactylate reduce interfacial tension, allowing each component to dissolve and disperse better in the solvent, thereby making the components more evenly mixed and facilitating the stable performance of the product's efficacy.

[0031] By adding bisabolol, bisabolol has good antibacterial and anti-inflammatory effects, and can effectively reduce the level of pro-inflammatory factor interleukin IL-1lalpha, thereby preventing and repairing keratinocyte inflammation, accelerating skin wound healing, promoting metabolism, and thus delaying skin aging.

[0032] The added skin care agent is emulsified and applied to the skin, which can form a breathable protective film on the surface of the skin, delay the evaporation of moisture inside the skin, play a moisturizing and emollient effect, and can also accelerate metabolism, increase the penetration of other ingredients, and help other effective ingredients to be better absorbed.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) The soothing and moisturizing skin care lotion provided by the present invention has glycerin and sodium hyaluronate added in the moisturizer, which have small molecular weights, can dissolve quickly, and can act on the skin surface. The small molecule hyaluronic acid can penetrate into the dermis, slightly dilate capillaries, increase blood circulation, improve intermediate metabolism, and promote skin nutrient absorption. Panthenol is a permeable moisturizer that can help sodium hyaluronate penetrate into the skin and cover the skin, and absorb moisture from the environment. When used in conjunction with glycerin, the water-locking and moisturizing effect is improved; the ceramide complex has a strong ability to eliminate wrinkles, increase skin elasticity, long-term moisturizing, delay skin aging, and promote the proliferation of epidermal cells. It can scavenge oxygen free radicals, inhibit lipid peroxidation, prevent and repair skin damage, and work together with antioxidants to further delay skin aging; carbomer, as a thickener, can increase the viscosity of the cleanser; the surfactant is composed of a variety of alcohols and esters. Cetearyl olive oil ester can make the emulsification system form a liquid crystal gel network structure with long-lasting moisturizing ability. Combined with hydrogenated lecithin, glyceryl stearate and sodium stearoyl lactylate, the special care lotion can have better spreadability; butylene glycol dicaprylate / dicaprate in the emollient can make the skin soft and unclog pores; bisabolol in the auxiliary agent can repair damaged skin, thereby delaying skin aging.

[0035] (2) The soothing and moisturizing skin care lotion provided by the present invention uses diatomaceous earth as the main raw material as the added modified composite carrier. The diatomaceous earth has a three-dimensional network structure and presents a very complex pore structure with a porosity of up to 80-90%. It has the characteristics of low density and high specific surface area. First, it is treated with hydrochloric acid to increase the specific surface area of the diatomaceous earth, improve its pore structure, form interconnected channels and gaps, increase the adsorption capacity, and facilitate the subsequent adsorption of superoxide dismutase; then, the microcrystalline cellulose is modified to form a three-dimensional network aerogel, which is then calcined and crushed at high temperature to obtain a modified diatomaceous earth powder material, which retains the advantages of aerogel being light, porous and having a high specific surface area. Its abundant pores cooperate with the good pore structure of diatomaceous earth to make the modified diatomaceous earth The soil powder maintains good water permeability and air permeability, further improving the modified diatomaceous earth powder's ability to retain moisture and fix superoxide dismutase; the modified diatomaceous earth powder is then reacted with ethyl orthosilicate to generate silica in situ on its surface; finally, the silica / modified diatomaceous earth powder is placed in a superoxide dismutase solution to form an immobilized enzyme on its surface; silica has good physical sunscreen and radiation protection properties, and synergistically acts with superoxide dismutase and antioxidants to improve the skin's antioxidant properties; natural nutrients such as meadowfoam seed oil, purslane extract, and ginger root extract in the skin care agent are then added to make them easily absorbed by the skin, thereby delaying and preventing aging and pathological changes of human skin, and having good sunscreen and moisturizing properties.

[0036] (3) The soothing and moisturizing skin care lotion provided by the present invention has a unique formula, obvious moisturizing effect, and a refreshing and non-greasy skin feel. Through the combined action of various substances, the prepared special care lotion has multiple functions such as scavenging free radicals, removing wrinkles and brightening skin color, and delaying skin aging. DETAILED DESCRIPTION

[0037] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0038] It should be noted that, unless otherwise specified, all chemical reagents involved in the present invention were purchased through commercial channels.

[0039] The diatomaceous earth was purchased from Shijiazhuang Qilu Diatomaceous Earth Co., Ltd., with a mesh size of 400 mesh; the microcrystalline cellulose was purchased from Henan Ruiren Bioengineering Co., Ltd., CAS: 9004-34-6.

[0040] Example 1

[0041] A soothing and moisturizing skin care lotion is composed of the following raw materials: 13g of moisturizer, 7g of emulsifier, 3g of surfactant, 12g of skin care agent, 0.5g of antioxidant, 7g of emollient, 8g of auxiliary agent, 0.03g of parahydroxyacetophenone, 0.4g of surfactant auxiliary agent, 5g of carbomer, 6g of modified composite carrier, 7g of ceramide complex, and 37g of water.

[0042] The moisturizing agent is a mixture of glycerin, sodium hyaluronate, butylene glycol, 1,2-hexanediol and panthenol in a mass ratio of 100:4:12:35:15;

[0043] The emulsifier is cetearyl alcohol;

[0044] The surfactant is a mixture of hydrogenated lecithin, glyceryl stearate, cetearyl olive oil ester and sodium stearoyl lactylate, with a mass ratio of 10:15:17:8;

[0045] The skin care agent is prepared by mixing meadowfoam seed oil, purslane extract, ginger root extract, Bacillus / soybean fermentation product extract and xanthan gum aqueous solution in a mass ratio of 80:15:7:13:15, and the mass concentration of the xanthan gum aqueous solution is 8%;

[0046] The antioxidant is a mixture of tocopherol and tocopherol acetate in a mass ratio of 1:2;

[0047] The emollient is a mixture of butylene glycol dicaprylate / dicaprate and dicaprylyl carbonate in a mass ratio of 10:15;

[0048] The auxiliary agent is a mixture of β-glucan, allantoin, arginine, bisabolol and folic acid, with a mass ratio of 50:3:1:12:0.3;

[0049] The surfactant is a mixture of sorbitan olivate and acetyl glucosamine in a mass ratio of 5:5;

[0050] The ceramide complex is prepared by mixing ceramide NP, ceramide EOP, ceramide AS and ceramide AP in a mass ratio of 20:1.5:0.2:0.7;

[0051] The preparation method of the modified composite carrier comprises the following steps:

[0052] (a) 50 g of diatomaceous earth was added to 400 mL of 13% dilute hydrochloric acid and soaked for 2.5 h. After soaking, the mixture was filtered, washed, and dried to obtain pretreated diatomaceous earth. Subsequently, 30 g of the pretreated diatomaceous earth was added to 110 mL of 8% sodium hydroxide solution, followed by addition of 8 g of microcrystalline cellulose and 12 g of urea. The mixture was stirred evenly and then ultrasonically treated to obtain a mixed solution. The mixed solution was then added to 300 mL of a mixed solvent of ethyl acetate and acetic acid (the mass fraction of ethyl acetate was 50%), stirred, allowed to stand, washed with water, and freeze-dried to obtain a cellulose / diatomaceous earth composite. The cellulose / diatomaceous earth composite was placed in a muffle furnace and calcined at a temperature of 700° C. for 4 h. After calcination, the composite was ground to obtain a modified diatomaceous earth powder.

[0053] (b) adding 8 g of 18% ammonia water to 130 g of anhydrous ethanol to obtain a mixed solution, adding the modified diatomaceous earth powder (30 g) in step (a) to the mixed solution, and then adding 12 g of ethyl orthosilicate dropwise under stirring to carry out a hydrothermal reaction at a temperature of 120° C. for 3 h. After the reaction is completed, filtering, drying, and washing to obtain a silica / modified diatomaceous earth powder;

[0054] (c) Superoxide dismutase was dissolved in deionized water to obtain an enzyme solution with a mass concentration of 3 g / L, and the silica / modified diatomaceous earth powder (30 g) obtained in step (b) was then immersed in 300 mL of the enzyme solution. After the immersion was completed, the solution was filtered, freeze-dried, ground, and passed through a 300-mesh sieve to obtain the modified composite support.

[0055] A method for preparing a soothing and moisturizing skin care lotion comprises the following steps:

[0056] (1) Weigh the raw materials according to the above formula, add the skin care agent, softener, 3.5g emulsifier and 6.5g moisturizer into the oil phase pot, stir and mix at 80°C to obtain material A;

[0057] (2) adding water, surfactant, antioxidant, auxiliary agent, surfactant auxiliary agent and the remaining emulsifier and moisturizer into the water phase pot, stirring and mixing at 75°C, and then pumping into the homogenizing emulsification pot, slowly adding the material A in step (1) into the emulsification pot under stirring conditions, and homogenizing and emulsifying. The homogenizing emulsification conditions are as follows: stirring speed of 1800r / min, time of 13min, vacuum degassing after emulsification is completed, cooling, and obtaining material B;

[0058] (3) When the material B in step (2) is cooled to 33° C., p-hydroxyacetophenone, carbomer, ceramide complex and modified composite carrier are added and secondary homogenization and emulsification is performed. The conditions of the secondary homogenization and emulsification are 1000 r / min and the time is 8 min. After the emulsification is completed, vacuum degassing is performed and the temperature is cooled to room temperature to obtain the soothing and moisturizing skin care lotion.

[0059] Example 2

[0060] A soothing and moisturizing skin care lotion is composed of the following raw materials: 15g of moisturizer, 3g of emulsifier, 2g of surfactant, 12g of skin care agent, 0.1g of antioxidant, 6g of emollient, 8g of auxiliary agent, 0.01g of parahydroxyacetophenone, 0.2g of surfactant auxiliary agent, 4g of carbomer, 4g of modified composite carrier, 6g of ceramide complex, and 35g of water.

[0061] The moisturizing agent is a mixture of glycerin, sodium hyaluronate, butylene glycol, 1,2-hexanediol and panthenol in a mass ratio of 100:2:10:30:10;

[0062] The emulsifier is cetearyl alcohol;

[0063] The surfactant is a mixture of hydrogenated lecithin, glyceryl stearate, cetearyl olive oil ester and sodium stearoyl lactylate, with a mass ratio of 10:10:15:5;

[0064] The skin care agent is prepared by mixing meadowfoam seed oil, purslane extract, ginger root extract, Bacillus / soybean fermentation product extract and xanthan gum aqueous solution in a mass ratio of 80:10:5:10:10, and the mass concentration of the xanthan gum aqueous solution is 10%;

[0065] The antioxidant is a mixture of tocopherol and tocopherol acetate in a mass ratio of 1:1;

[0066] The emollient is a mixture of butylene glycol dicaprylate / dicaprate and dicaprylyl carbonate in a mass ratio of 10:5;

[0067] The auxiliary agent is a mixture of β-glucan, allantoin, arginine, bisabolol and folic acid, with a mass ratio of 50:2:0.5:10:0.1;

[0068] The surfactant is a mixture of sorbitan olivate and acetyl glucosamine in a mass ratio of 5:3.

[0069] The ceramide complex is prepared by mixing ceramide NP, ceramide EOP, ceramide AS and ceramide AP in a mass ratio of 20:1:0.1:0.5;

[0070] The preparation method of the modified composite carrier comprises the following steps:

[0071] (a) 50 g of diatomaceous earth was added to 400 mL of 10% dilute hydrochloric acid and soaked for 3 h. After soaking, the mixture was filtered, washed, and dried to obtain pretreated diatomaceous earth. Subsequently, 30 g of the pretreated diatomaceous earth was added to 100 mL of 10% sodium hydroxide solution, followed by addition of 5 g of microcrystalline cellulose and 10 g of urea. The mixture was stirred evenly and then ultrasonically treated to obtain a mixed solution. The mixed solution was then added to 300 mL of a mixed solvent of ethyl acetate and acetic acid (the mass fraction of ethyl acetate was 40%), stirred and allowed to stand, washed with water, and freeze-dried to obtain a cellulose / diatomaceous earth composite. The cellulose / diatomaceous earth composite was placed in a muffle furnace and calcined at a temperature of 600° C. for 5 h. After calcination, the composite was ground to obtain a modified diatomaceous earth powder.

[0072] (b) adding 5 g of 20% ammonia water to 120 g of anhydrous ethanol to obtain a mixed solution, adding the modified diatomaceous earth powder (30 g) in step (a) to the mixed solution, and then adding 10 g of ethyl orthosilicate dropwise under stirring to carry out a hydrothermal reaction at a temperature of 100° C. for 4 h. After the reaction is completed, filtering, drying, and washing to obtain a silica / modified diatomaceous earth powder;

[0073] (c) dissolving superoxide dismutase in deionized water to obtain an enzyme solution with a mass concentration of 2 g / L, and then immersing the silica / modified diatomaceous earth powder (30 g) obtained in step (b) in 300 mL of the enzyme solution. After immersion, the mixture was filtered, freeze-dried, ground, and passed through a 300-mesh sieve to obtain the modified composite support.

[0074] A method for preparing a soothing and moisturizing skin care lotion comprises the following steps:

[0075] (1) Weigh the raw materials according to the above formula, add the skin care agent, emollient, 1.5g emulsifier and 7.5g moisturizer into the oil phase pot, stir and mix at 75°C to obtain material A;

[0076] (2) adding water, surfactant, antioxidant, auxiliary agent, surfactant auxiliary agent and the remaining emulsifier and moisturizer into the water phase pot, stirring and mixing at 70°C, and then pumping into the homogenizing emulsification pot, slowly adding the material A in step (1) into the emulsification pot under stirring conditions, and homogenizing and emulsifying. The homogenizing emulsification conditions are as follows: stirring speed of 1500r / min, time of 15min, vacuum degassing after emulsification, cooling, and obtaining material B;

[0077] (3) When the material B in step (2) is cooled to 30° C., p-hydroxyacetophenone, carbomer, ceramide complex and modified composite carrier are added and secondary homogenization and emulsification is performed. The conditions of the secondary homogenization and emulsification are 800 r / min and the time is 10 min. After the emulsification is completed, vacuum degassing is performed and the temperature is cooled to room temperature to obtain the soothing and moisturizing skin care lotion.

[0078] Example 3

[0079] A soothing and moisturizing skin care lotion is composed of the following raw materials: 15g of moisturizer, 8g of emulsifier, 4g of surfactant, 15g of skin care agent, 1g of antioxidant, 9g of emollient, 10g of auxiliary agent, 0.05g of parahydroxyacetophenone, 0.5g of surfactant auxiliary agent, 6g of carbomer, 8g of modified composite carrier, 8g of ceramide complex, and 45g of water.

[0080] The moisturizing agent is a mixture of glycerin, sodium hyaluronate, butylene glycol, 1,2-hexanediol and panthenol in a mass ratio of 100:5:15:40:20;

[0081] The emulsifier is cetearyl alcohol;

[0082] The surfactant is a mixture of hydrogenated lecithin, glyceryl stearate, cetearyl olive oil ester and sodium stearoyl lactylate in a mass ratio of 10:20:20:10;

[0083] The skin care agent is prepared by mixing meadowfoam seed oil, purslane extract, ginger root extract, Bacillus / soybean fermentation product extract and xanthan gum aqueous solution in a mass ratio of 80:20:10:15:20, and the mass concentration of the xanthan gum aqueous solution is 5%;

[0084] The antioxidant is a mixture of tocopherol and tocopherol acetate in a mass ratio of 1:3;

[0085] The emollient is a mixture of butylene glycol dicaprylate / dicaprate and dicaprylyl carbonate in a mass ratio of 10:20;

[0086] The auxiliary agent is a mixture of β-glucan, allantoin, arginine, bisabolol and folic acid, and the mass ratio thereof is 50:5:2:15:0.5;

[0087] The surfactant is a mixture of sorbitan olivate and acetyl glucosamine in a mass ratio of 5:8;

[0088] The ceramide complex is composed of a mixture of ceramide NP, ceramide EOP, ceramide AS and ceramide AP in a mass ratio of 20:2:0.3:1;

[0089] The preparation method of the modified composite carrier comprises the following steps:

[0090] (a) 50 g of diatomaceous earth was added to 400 mL of 15% dilute hydrochloric acid and soaked for 2 h. After soaking, the mixture was filtered, washed, and dried to obtain pretreated diatomaceous earth. Subsequently, 30 g of the pretreated diatomaceous earth was added to 120 mL of 5% sodium hydroxide solution, followed by addition of 10 g of microcrystalline cellulose and 15 g of urea. The mixture was stirred evenly and then ultrasonically treated to obtain a mixed solution. The mixed solution was then added to 300 mL of a mixed solvent of ethyl acetate and acetic acid (the mass fraction of ethyl acetate was 60%), stirred and allowed to stand, washed with water, and freeze-dried to obtain a cellulose / diatomaceous earth composite. The cellulose / diatomaceous earth composite was placed in a muffle furnace and calcined at a temperature of 750° C. for 3 h. After calcination, the composite was ground to obtain a modified diatomaceous earth powder.

[0091] (b) adding 10 g of 15% ammonia water to 140 g of anhydrous ethanol to obtain a mixed solution, adding the modified diatomaceous earth powder (30 g) in step (a) to the mixed solution, and then adding 15 g of ethyl orthosilicate dropwise under stirring to carry out a hydrothermal reaction at a temperature of 130° C. for 2 h. After the reaction is completed, filtering, drying, and washing to obtain a silica / modified diatomaceous earth powder;

[0092] (c) dissolving superoxide dismutase in deionized water to obtain an enzyme solution with a mass concentration of 4 g / L, and then immersing the silica / modified diatomaceous earth powder (30 g) obtained in step (b) in 300 mL of the enzyme solution. After immersion, the solution was filtered, freeze-dried, ground, and passed through a 300-mesh sieve to obtain the modified composite support.

[0093] A method for preparing a soothing and moisturizing skin care lotion comprises the following steps:

[0094] (1) Weigh the raw materials according to the above formula, add the skin care agent, softener, 4g emulsifier and 7.5g moisturizer into the oil phase pot, stir and mix at 85°C to obtain material A;

[0095] (2) adding water, surfactant, antioxidant, auxiliary agent, surfactant auxiliary agent and the remaining emulsifier and moisturizer into the water phase pot, stirring and mixing at 80°C, and then pumping into the homogenizing emulsification pot, slowly adding the material A in step (1) into the emulsification pot under stirring conditions, and homogenizing and emulsifying. The homogenizing emulsification conditions are as follows: stirring speed 2000r / min, time is 10min, vacuum degassing after emulsification is completed, cooling, and obtaining material B;

[0096] (3) When the material B in step (2) is cooled to 36° C., p-hydroxyacetophenone, carbomer, ceramide complex and modified composite carrier are added and secondary homogenization and emulsification is performed. The conditions of the secondary homogenization and emulsification are 1200 r / min and the time is 5 min. After the emulsification is completed, vacuum degassing is performed and the temperature is cooled to room temperature to obtain the soothing and moisturizing skin care lotion.

[0097] Comparative Example 1

[0098] A soothing and moisturizing skin care lotion is composed of the following raw materials: 13g of moisturizer, 7g of emulsifier, 3g of surfactant, 12g of skin care agent, 0.5g of antioxidant, 7g of emollient, 8g of auxiliary agent, 0.03g of parahydroxyacetophenone, 0.4g of surfactant auxiliary agent, 5g of carbomer, 6g of modified carrier, 7g of ceramide complex, and 37g of water.

[0099] The moisturizing agent is a mixture of glycerin, sodium hyaluronate, butylene glycol, 1,2-hexanediol and panthenol in a mass ratio of 100:4:12:35:15;

[0100] The emulsifier is cetearyl alcohol;

[0101] The surfactant is a mixture of hydrogenated lecithin, glyceryl stearate, cetearyl olive oil ester and sodium stearoyl lactylate, with a mass ratio of 10:15:17:8;

[0102] The skin care agent is prepared by mixing meadowfoam seed oil, purslane extract, ginger root extract, Bacillus / soybean fermentation product extract and xanthan gum aqueous solution in a mass ratio of 80:15:7:13:15, and the mass concentration of the xanthan gum aqueous solution is 8%;

[0103] The antioxidant is a mixture of tocopherol and tocopherol acetate in a mass ratio of 1:2;

[0104] The emollient is a mixture of butylene glycol dicaprylate / dicaprate and dicaprylyl carbonate in a mass ratio of 10:15;

[0105] The auxiliary agent is a mixture of β-glucan, allantoin, arginine, bisabolol and folic acid, with a mass ratio of 50:3:1:12:0.3;

[0106] The surfactant is a mixture of sorbitan olivate and acetyl glucosamine in a mass ratio of 5:5;

[0107] The ceramide complex is prepared by mixing ceramide NP, ceramide EOP, ceramide AS and ceramide AP in a mass ratio of 20:1.5:0.2:0.7;

[0108] The preparation method of the modified carrier comprises the following steps:

[0109] Superoxide dismutase was dissolved in deionized water to obtain an enzyme solution with a mass concentration of 3 g / L. Subsequently, 30 g of diatomaceous earth powder was immersed in 300 mL of the enzyme solution. After the immersion, the solution was filtered, freeze-dried, ground, and passed through a 300-mesh sieve to obtain the modified carrier.

[0110] A method for preparing a soothing and moisturizing skin care lotion comprises the following steps:

[0111] (1) Weigh the raw materials according to the above formula, add the skin care agent, softener, 3.5g emulsifier and 6.5g moisturizer into the oil phase pot, stir and mix at 80°C to obtain material A;

[0112] (2) adding water, surfactant, antioxidant, auxiliary agent, surfactant auxiliary agent and the remaining emulsifier and moisturizer into the water phase pot, stirring and mixing at 75°C, and then pumping into the homogenizing emulsification pot, slowly adding the material A in step (1) into the emulsification pot under stirring conditions, and homogenizing and emulsifying. The homogenizing emulsification conditions are as follows: stirring speed of 1800r / min, time of 13min, vacuum degassing after emulsification is completed, cooling, and obtaining material B;

[0113] (3) When the material B in step (2) is cooled to 33° C., p-hydroxyacetophenone, carbomer, ceramide complex and modified carrier are added and a secondary homogenization emulsification is performed. The secondary homogenization emulsification conditions are 1000 r / min and the time is 8 min. After the emulsification is completed, vacuum degassing is performed and the temperature is cooled to room temperature to obtain the soothing and moisturizing skin care lotion.

[0114] The soothing and moisturizing skin care lotions prepared in Examples 1-3 and Comparative Example 1 were subjected to efficacy experiments.

[0115] 1. Moisturizing test

[0116] Reference standard: Refer to QB / T 4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics.

[0117] Testers: 60 healthy volunteers aged 30-40 years old (male and female) were selected and randomly divided into 4 groups, with 15 people in each group.

[0118] Test conditions: Capacitive skin moisture meter, test temperature 23-25℃, humidity 40-60%.

[0119] Test principle: The capacitance method is used to determine the moisture content of the stratum corneum of human skin. It is based on the significant difference in dielectric constants between water and other substances. According to the different moisture content of the stratum corneum of the skin, the measured capacitance value of the skin is different, and its parameter can represent the skin moisture content (MMV).

[0120] Test method: Three fixed points were measured in a certain order in each area, and the average value was calculated. Then, the soothing and moisturizing skin care lotion was applied to the test area (about 0.05g). At 0h, 1h, 2h, 4h and 8h, the skin moisture content of the test area was measured using a probe. The average value of each group at the corresponding time point was calculated. The larger the value, the better the moisturizing effect of the test sample. The specific test results are shown in Table 1:

[0121] Table 1

[0122]

[0123]

[0124] 2. Scavenging effect on DPPH free radicals

[0125] The soothing and moisturizing skin care lotion samples prepared in Examples 1-3 and Comparative Example 1 were prepared into a 1 mg / mL test solution. 3 mL of the test solution was added to 3 mL of a 0.1 mmol / L DPPH solution (dissolved in anhydrous ethanol). After mixing, the samples were placed at room temperature for 30 minutes and the absorbance of each mass concentration (A) was measured at 517 nm. i ). Parallel determination was performed 3 times and the average value was taken. At the same time, 3 mL of the test solution was added to 3 mL of anhydrous ethanol and the absorbance (A j In addition, 3 mL of anhydrous ethanol was taken instead of the sample and 3 mL of DPPH free radical solution was added to measure the blank absorbance (A o ). DPPH free radical scavenging rate was calculated according to formula (I). The test results are shown in Table 2 below:

[0126]

[0127] Table 2

[0128] Clearance rate (%) Example 1 94.5 Example 2 93.7 Example 3 93.9 Comparative Example 1 80.3

[0129] 3. Skin elasticity test

[0130] Experimental Method: 60 healthy volunteers aged 30-40 were randomly divided into four groups of 15 each. The samples were applied twice daily, morning and evening. During the experiment, the subjects were not allowed to apply any other cosmetics to the test areas.

[0131] Skin elasticity test: Use a skin elasticity meter to test the skin condition in the second and fourth weeks respectively. The test site is the arm. During the measurement, the probe repeats the measurement 3 times in the same test area and takes the average value.

[0132] Skin elasticity growth rate W% = (B n -B0) / B0×100%

[0133] B0-skin elasticity test value before application; B n - Elasticity test value after n periods of time.

[0134] The specific test results are shown in Table 3:

[0135] Table 3

[0136] After 2 weeks (skin elasticity increase %) After 4 weeks (skin elasticity increase %) Example 1 12.2 25.7 Example 2 12.7 25.2 Example 3 11.9 24.9 Comparative Example 1 10.1 18.4

[0137] As can be seen from Tables 1-3, the soothing and moisturizing skin care lotion provided by the present invention has the effects of soothing the skin, repairing the skin barrier, and improving skin tolerance, and can also have the multiple effects of moisturizing, increasing skin elasticity, improving antioxidant properties and delaying skin aging.

[0138] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A soothing and moisturizing skin care lotion, characterized in that: By weight, it is composed of the following raw materials: 10-15 parts of moisturizer, 3-8 parts of emulsifier, 2-4 parts of surfactant, 10-15 parts of skin care agent, 0.1-1 part of antioxidant, 5-9 parts of emollient, 5-10 parts of auxiliary agent, 0.01-0.05 parts of p-hydroxyacetophenone, 0.2-0.5 parts of surfactant, 3-6 parts of carbomer, 4-8 parts of modified composite carrier, 5-8 parts of ceramide complex, 30-45 parts of water; The moisturizing agent is a mixture of glycerin, sodium hyaluronate, butylene glycol, 1,2-hexanediol and panthenol, and the mass ratio is 100:2-5:10-15:30-40:10-20; the skin care agent is a mixture of white meadowfoam seed oil, purslane extract, ginger root extract, Bacillus / soybean fermentation product extract and xanthan gum aqueous solution, and the mass ratio is 80:10-20:5-10:10-15:10-20, and the mass concentration of the xanthan gum aqueous solution is 5-10%; the antioxidant is tocopherol and tocopheryl acetate. The mass ratio of the mixture is 1:1-3; the auxiliary agent is composed of β-glucan, allantoin, arginine, bisabolol and folic acid, and the mass ratio is 50:2-5:0.5-2:10-15:0.1-0.5; the surfactant auxiliary agent is composed of sorbitan olivate and acetyl glucosamine, and the mass ratio is 5:3-8; the ceramide complex is composed of ceramide NP, ceramide EOP, ceramide AS and ceramide AP, and the mass ratio is 20:1-2:0.1-0.3:0.5-1; The preparation method of the modified composite carrier comprises the following steps: (a) diatomaceous earth is soaked in dilute hydrochloric acid, filtered, washed, and dried to obtain pretreated diatomaceous earth, then the pretreated diatomaceous earth is added to a sodium hydroxide solution, followed by microcrystalline cellulose and urea, stirred evenly, and then ultrasonically treated to obtain a mixed solution, then the mixed solution is added to a mixed solvent of ethyl acetate and acetic acid, stirred, allowed to stand, washed with water, and freeze-dried to obtain a cellulose / diatomaceous earth composite; the cellulose / diatomaceous earth composite is calcined in a muffle furnace, and after calcination, ground to obtain a modified diatomaceous earth powder; (b) adding aqueous ammonia to anhydrous ethanol to obtain a mixed solution, adding the modified diatomaceous earth powder obtained in step (a) to the mixed solution, then adding ethyl orthosilicate dropwise under stirring to carry out a hydrothermal reaction, and after completion of the reaction, filtering, drying, and washing to obtain a silica / modified diatomaceous earth powder; (c) dissolving superoxide dismutase in deionized water to obtain an enzyme solution, and then impregnating the silica / modified diatomaceous earth powder obtained in step (b) into the enzyme solution. After impregnation, the mixture is filtered, freeze-dried, ground, and passed through a 300-mesh sieve to obtain the modified composite carrier.

2. The soothing and moisturizing skin care lotion according to claim 1, characterized in that: By weight, it is composed of the following raw materials: 13 parts of moisturizer, 7 parts of emulsifier, 3 parts of surfactant, 12 parts of skin care agent, 0.5 parts of antioxidant, 7 parts of emollient, 8 parts of auxiliary agent, 0.03 parts of p-hydroxyacetophenone, 0.4 parts of surfactant auxiliary agent, 5 parts of carbomer, 6 parts of modified composite carrier, 7 parts of ceramide complex, and 37 parts of water.

3. The soothing and moisturizing skin care lotion according to claim 1, characterized in that: The emulsifier is cetearyl alcohol; the surfactant is a mixture of hydrogenated lecithin, glyceryl stearate, cetearyl olive oil ester, and sodium stearoyl lactylate, with a mass ratio of 10:10-20:15-20:5-10.

4. The soothing and moisturizing skin care lotion according to claim 1, characterized in that: The emollient is prepared by mixing butylene glycol dicaprylate / dicaprate and dicaprylyl carbonate in a mass ratio of 10:5-20.

5. The soothing and moisturizing skin care lotion according to claim 1, characterized in that: The mass concentration of the dilute hydrochloric acid in step (a) is 10-15%; the soaking time is 2-3 hours; the mass concentration of the sodium hydroxide is 5-10%; the mass ratio of the pretreated diatomaceous earth, sodium hydroxide solution, microcrystalline cellulose, and urea is 30:100-120:5-10:10-15; the mass fraction of ethyl acetate in the mixed solvent of ethyl acetate and acetic acid is 40-60%; the calcination temperature is 600-750° C., and the time is 3-5 hours.

6. The soothing and moisturizing skin care lotion according to claim 1, characterized in that: The mass concentration of the ammonia water in step (b) is 15-20%; the mass ratio of the modified diatomite powder, ammonia water, anhydrous ethanol, and ethyl orthosilicate is 30:5-10:120-140:10-15; the temperature of the hydrothermal reaction is 100-130° C., and the reaction time is 2-4 hours.

7. The soothing and moisturizing skin care lotion according to claim 1, characterized in that: The concentration of superoxide dismutase in the enzyme solution in step (c) is 2-4 g / L; the immersion temperature is 15-25° C., and the immersion time is 5-10 h.

8. A method for preparing the soothing and moisturizing skin care lotion according to any one of claims 1 to 7, characterized in that: The following steps are involved: (1) Add skin care agent, emollient, 1.5-4 parts of emulsifier and 5-8 parts of moisturizer into the oil phase pot, stir and mix at 75-85°C to obtain material A; (2) Add water, surfactant, antioxidant, auxiliary agent, surfactant auxiliary agent and the remaining emulsifier and moisturizer into the water phase pot, stir and mix evenly at 70-80°C, then pump into the homogenizing emulsification pot, slowly add the material A in step (1) into the emulsification pot under stirring conditions, homogenize and emulsify, vacuum degassing after emulsification is completed, cooling, and obtaining material B; (3) When the temperature of material B in step (2) is lowered to 30-36°C, p-hydroxyacetophenone, carbomer, ceramide complex and modified composite carrier are added and homogenized and emulsified twice. After the emulsification is completed, vacuum degassing is performed and the material is cooled to room temperature to obtain the soothing and moisturizing skin care lotion.

9. The preparation method according to claim 8, characterized in that The conditions for the homogenization and emulsification in step (2) are a stirring speed of 1500-2000 r / min and a time of 10-15 min; the conditions for the secondary homogenization and emulsification in step (3) are 800-1200 r / min and a time of 5-10 min.

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