External Chinese medicine composition for treating synovitis and tenosynovitis and preparation method thereof

Abstract

The invention provides a Chinese medicine composition for external use for treating synovitis and tenosynovitis and a preparation method thereof. The raw materials of the Chinese medicine composition for external use are: processed chuanwu, chuanxiong, rhubarb, dactylorhizon, pittosporum tobira bark, angelica, red peony root, angelica dahurica, white scutellaria, forsythia, cyperus rotundus, clematis, pulsatilla, sapodilla, radix scutellariae, camphor, myrrh, scutellaria baicalensis, frankincense, and schizonepeta. The Chinese medicine composition for external use of the invention has a simple preparation process, and the medicines are used together to play the effects of removing dampness and removing arthralgia, dredging collaterals and relieving pain, relaxing muscles and activating blood circulation, warming and unblocking meridians, and anti-inflammatory and analgesic, and has a very significant therapeutic effect on synovitis and tenosynovitis.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external Chinese medicine composition for treating synovitis and tenosynovitis and a preparation method thereof. Background Art

[0002] Synovitis is a common orthopedic disease in clinical practice. It is a joint disease caused by inflammation of the synovium due to stimulation, resulting in an imbalance of secretions and the formation of effusion. Articular cartilage damage, intra-articular fractures, joint dislocations, ligament injuries, loose joint bodies, etc. can all cause synovial injury. Tenosynovitis, or stenosing tenosynovitis, refers to excessive friction or repeated wear of the tendon in the tendon sheath for a long time, leading to inflammatory changes such as congestion, increased exudation, and thickening of the synovium, causing thickening, adhesion or stenosis of the tendon sheath wall, and obstruction of tendon sliding, resulting in pain, snapping, and limited movement in the corresponding parts. It can occur in the fingers, toes, wrists, ankles, shoulders, and other parts.

[0003] In traditional Chinese medicine, synovitis is classified as "arthralgia" because its main symptom is pain; tenosynovitis belongs to the category of "tendon arthralgia" and "tendon injury" in traditional Chinese medicine. According to traditional Chinese medicine, synovitis is caused by obstruction of meridians, retention of dampness, turbidity, phlegm and blood stasis; tenosynovitis is caused by strain and damage to meridians and tendons, or invasion of cold and dampness into the veins, obstruction of meridians, poor circulation of qi and blood, and stagnation of qi and blood stasis. In general, synovitis and tenosynovitis both belong to the category of "arthralgia" in traditional Chinese medicine. There are many ways to treat synovitis and tenosynovitis in traditional Chinese medicine, such as oral Chinese medicine decoction, external application of Chinese medicine, hot compress of Chinese medicine, fumigation of Chinese medicine, acupuncture, cupping, massage, moxibustion, medicinal wine, etc. Although these treatment methods have certain curative effects, they are either bad in taste and bitter in the mouth, making it difficult for patients to accept, and the treatment methods are inconvenient, such as fumigation, acupuncture, cupping, massage, etc., which require more professional people to operate and treat, which is time-consuming and laborious. Therefore, how to provide a Chinese medicine composition for external use that has clear efficacy, is easy to use, safe and has no toxic side effects for treating synovitis and tenosynovitis is an urgent problem to be solved by those skilled in the art. Summary of the invention

[0004] In view of the deficiencies in the prior art, the object of the present invention is to provide a Chinese medicine composition for external use and a preparation method and application thereof, and in particular to provide a Chinese medicine composition for external use for treating synovitis and tenosynovitis and a preparation method and application thereof.

[0005] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0006] In a first aspect, the present invention provides a Chinese medicine composition for external use for treating synovitis and tenosynovitis, which is composed of the following raw materials: 10-30 parts of processed Chuanwu, 10-30 parts of Chuanxiong, 5-25 parts of rhubarb, 5-25 parts of Rhizoma Dioscoreae, 10-30 parts of Pittosporum tobira bark, 10-30 parts of Angelica sinensis, 3-20 parts of red peony root, 3-20 parts of Angelica dahurica, 3-20 parts of white mulberry, 10-20 parts of Forsythia suspensa, 3-20 parts of Semen Armeniacae Atractylodes, 10-20 parts of 10-30 parts of Polygonum multiflorum, 5-25 parts of Pulsatilla chinensis, 5-15 parts of Gleditsia sinensis, 5-15 parts of Herba spatholobi, 10-30 parts of Campsis creeper, 5-25 parts of Carthamus tinctorius, 5-25 parts of Osmanthus fragrans, 5-20 parts of Sinapis alba, 5-20 parts of Caulis quinata, 5-25 parts of Snakehead acutus, 3-12 parts of Scolopendra subspinipes, 3-12 parts of Camphor, 5-20 parts of Myrrha, 15-30 parts of Buza leaves, 5-20 parts of Olibanum, and 5-20 parts of Schizonepeta tenuifolia.

[0007] Preferably, the raw materials of the external Chinese medicine composition are as follows: 15-30 parts of processed Chuanwu, 15-25 parts of Chuanxiong, 10-20 parts of Rhubarb, 10-25 parts of Rhizoma Dioscoreae, 15-30 parts of Pittosporum tobira bark, 15-25 parts of Angelica sinensis, 5-15 parts of Red Peony Root, 5-15 parts of Angelica dahurica, 5-15 parts of Bletilla striata, 12-18 parts of Forsythia suspensa, 5-15 parts of Fructus Aconiti Lateralis, 15-30 parts of Clematis chinensis, 15-25 parts of Radix Glehniae, 15-30 parts of Radix Glehniae, 15-25 parts of Radix Angelicae Sinensis, 5-15 parts of Radix Paeoniae Rubra, 5-15 parts of Radix Angelicae Dahuricae, 5-15 parts of Radix Ampelopsis, 12-18 parts of Fructus Forsythiae, 5-15 parts of Fructus Aconiti Lateralis, 15-30 parts of Radix Clematis, 15-25 parts of Radix Glehniae 10-25 parts of Rhizoma Cibotii, 7-15 parts of Gleditsia sinensis, 7-15 parts of Herba Scutellariae, 15-30 parts of Flos Campsis, 10-22 parts of Flos Carthami, 10-22 parts of Cassia twigs, 7-18 parts of Semen Sinapis, 7-18 parts of Caulis Agaricuses, 10-25 parts of Snakeheads, 5-10 parts of Scolopendra, 5-10 parts of Camphor, 8-18 parts of Myrrha, 20-25 parts of Folium Buza, 10-20 parts of Olibanum, and 10-20 parts of Semen Viscum.

[0008] More preferably, the raw materials of the external Chinese medicine composition are composed of: 30 parts of processed Chuanwu, 22 parts of Chuanxiong, 12 parts of rhubarb, 18 parts of Rhizoma Dioscoreae, 30 parts of Pittosporum tobira, 25 parts of Angelica sinensis, 12 parts of red peony root, 10 parts of Angelica dahurica, 10 parts of Bletilla striata, 15 parts of Forsythia suspensa, 12 parts of Semen Corydalis, 25 parts of Clematidis, 17 parts of Pulsatilla, 9 parts of Gleditsia sinensis, 10 parts of Herba Polygoni Multiflori, 30 parts of Campsis creeper, 20 parts of Carthamus tinctorius, 15 parts of Cinnamomum officinale, 10 parts of Sinapis alba, 10 parts of Caulis Sinensis, 14 parts of Snakehead acanthus, 8 parts of Scolopendra subspinipes, 6 parts of Camphor, 13 parts of Myrrha, 22 parts of Buza leaves, 15 parts of frankincense, and 15 parts of Vitex schizonepeta.

[0009] In a second aspect, the present invention provides a method for preparing the external Chinese medicine composition, comprising the following steps:

[0010] S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use;

[0011] S2. Take the Chinese medicine powder obtained in step S1, add 5-12 times the weight of the powder in an amount of 80% ethanol solution, ultrasonically extract for 1-6 h, filter and obtain the filtrate and residue, and set aside;

[0012] S3. Weigh angelica dahurica, white peony root, forsythia, wood beetle, clematis, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, vine, black snake, centipede, camphor, myrrh, cloth residue leaf, frankincense by weight fraction, grind into coarse powder, add 85% ethanol solution 2-3 times the weight of the coarse powder and soak for 1-3 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into the percolator with absorbent cotton at the bottom in 2-3 times, and then load the filter residue obtained in step S2 in 1-2 times, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 2-6 h, collect the percolate and set aside;

[0013] S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 40-60% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution;

[0014] S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

[0015] Furthermore, in step S2, the amount of ethanol solution used is 8 times, and the extraction time is 3.5 h.

[0016] Furthermore, the diafiltration extraction time in step S3 is 4 h, and the concentrated volume in step S4 is 50% of the original volume.

[0017] In a third aspect, the present invention provides an application of the external Chinese medicine composition in the preparation of a medicine for treating synovitis and tenosynovitis.

[0018] The various Chinese medicines involved in the present invention can be purchased from general Chinese medicine stores, and their specifications meet the standards of the Chinese Pharmacopoeia.

[0019] Among them, processed Chuanwu is a processed product of the dried root of Aconitum carmichaeli Debx., a plant of the Ranunculaceae family. It has the effects of dispelling wind and dampness, warming the meridians and relieving pain. It is used for wind-cold-dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, and anesthesia and pain relief.

[0020] Among them, Chuanxiong is the rhizome of the Umbelliferae herbaceous plant Chuanxiong Host. It has the effects of promoting qi and relieving depression, removing wind and dampness, promoting blood circulation and relieving pain. It can treat wind-cold headache, dizziness, flank pain and abdominal pain, cold arthralgia and muscle spasm, amenorrhea, dystocia, postpartum blood stasis and pain, carbuncle and ulcer. It is used for irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to mass, stabbing pain in the chest and flank, swelling and pain due to falls, headache, and rheumatic pain.

[0021] Rhubarb is the dried root and rhizome of Rheum palmatum L, Rheumtanguticum Maximex Balf or Rheum officinale Baill of the Polygonaceae family. It has the effects of purging heat and clearing the intestines, cooling blood and detoxifying, and removing blood stasis and dredges the menstrual period. It is used for constipation due to excess heat, abdominal pain due to accumulation, diarrhea, jaundice due to damp heat, vomiting and bleeding due to blood heat, red eyes, swollen throat, abdominal pain due to intestinal carbuncle, carbuncle furuncle, amenorrhea due to blood stasis, traumatic injury, external treatment of burns caused by water or fire; upper gastrointestinal bleeding. Wine rhubarb is good at clearing heat and toxicity in the upper part of the blood. It is used for red eyes, swollen throat, and swollen and painful gums. Cooked rhubarb has a slow purgative effect, purging fire and detoxifying. It is used for fire toxicity sores.

[0022] Among them, Dioscorea nipponica Makino is a plant of the Dioscoreaceae family, Dioscorea genus, and its rhizome is used as medicine. It has the effects of promoting blood circulation and relaxing muscles, promoting digestion and diuresis, and removing phlegm and stopping malaria. It can treat wind-cold dampness, chronic tracheitis, indigestion, strain and sprain, malaria, and carbuncle.

[0023] Among them, Pittosporum bark is the bark or root bark of Erythrina indica Lam., a tree of the Leguminosae family. It has the effects of removing rheumatism, relaxing muscles and unblocking meridians. It is used for rheumatic numbness, pain in the waist and legs, and injuries from falls; it can also be used externally to treat various stubborn ringworms.

[0024] Among them, Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels of the Umbelliferae family. It has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, constipation due to dry intestines, rheumatism and pain, injuries caused by falls, carbuncles and ulcers. Wine Angelica sinensis activates blood circulation and regulates menstruation. It is used for amenorrhea and dysmenorrhea, rheumatism and pain, injuries caused by falls.

[0025] Among them, red peony root is the dried root of Paeonia lactiflora Pall. or Paeonia veitchii Lynch, a plant of the Ranunculaceae family. It has the effects of clearing away heat, cooling blood, dispersing blood stasis and relieving pain. It is used for fever and toxicity, vomiting blood, epistaxis, red and swollen eyes, liver depression and flank pain, amenorrhea and dysmenorrhea, abdominal pain due to lumps, injuries from falls, carbuncles, swellings and ulcers.

[0026] Angelica dahurica is the dried root of Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f. or Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan. It has the effects of dispersing wind and dampness, opening the orifices and relieving pain, and reducing swelling and draining pus. It is used for colds and headaches, brow pain, nasal congestion, sinusitis, toothache, leucorrhea, and sores and swelling.

[0027] Among them, Ampelopsis japonica is the dried root of Ampelopsis japonica (Thunb.) Makino, a plant of the grape family. It has the effects of clearing away heat and detoxifying, eliminating carbuncle and dispersing knots. It is used for carbuncle, furuncle, scrofula, and burns caused by water or fire.

[0028] Among them, Forsythia suspensa is the dried fruit of Forsythia suspensa (Thunb.) Vahl, a plant of the Oleaceae family. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules. It is used for carbuncle, scrofula, breast carbuncle, erysipelas, wind-heat cold, the initial stage of febrile disease, warm and heat entering the Ying, high fever and thirst, coma and rash, and heat stranguria and urinary retention.

[0029] Among them, Mubiezi is the dried mature seeds of Momordica cochinchinensis (Lour.) Spreng., a plant of the Cucurbitaceae family. It has the effects of dispersing nodules and reducing swelling, attacking toxins and curing sores. It is used for sores, swelling and toxins, breast abscesses, scrofula, hemorrhoid fistula, psoriasis, and baldness.

[0030] Among them, Clematis chinensis is the root and rhizome of Clematis chinensis Osbeck, Clematis hexapetala Pall or Clematis manshurica Rupr. of the Ranunculaceae family. It has the effects of removing rheumatism and unblocking meridians. It is used for rheumatic arthralgia, numbness of limbs, spasm of tendons and veins, and difficulty in flexion and extension.

[0031] Among them, Pulsatilla chinensis is the dried root of Pulsatilla chinensis (Bge.) Regel, a plant of the Ranunculaceae family. It has the effects of clearing away heat and detoxifying, cooling blood and stopping dysentery. It is used for heat-toxic bloody dysentery, vaginal itching and leucorrhea, and amoebic dysentery.

[0032] Among them, sapodilla is the mature fruit of the leguminous plant Gleditsia sinensis Lam. It has the effects of opening the orifices and removing phlegm, dispersing stagnation and reducing swelling, moistening dryness and relieving constipation. It is used to open the orifices and search for wind, relieve heat and expectorate, remove dampness and dirt, break up stagnation and relieve stagnation, and disperse swelling and disinfect.

[0033] Among them, the whole herb of Speranskia tuberculata (Bunge) Baill. of the Euphorbiaceae family, Impatiens balsamina L. of the Impatiens family, Incarvillea sinensis Lam. of the Bignoniaceae family, Vicia amoena Fisch. of the Leguminosae family, and the whole plant of Gaultheria yunnanensis (Franch.) Rehd. of the Ericaceae family. It has the effects of dispelling wind and dampness, detoxifying and relieving pain. It is used for rheumatic joint pain; externally for sores, ulcers, swelling and toxins.

[0034] Among them, trumpet creeper is the dried flower and root of Campsis grandiflora (Thunb.) K. Schum. or Campsis radicans (L.) Seem. of the family Campsis grandiflora. It has the effects of cooling blood, removing blood stasis, dispelling wind, promoting blood circulation and dispersing blood stasis, detoxifying and reducing swelling. It is used for irregular menstruation, amenorrhea, postpartum breast swelling, erythema, itchy skin, acne, rheumatic pain, traumatic injury, fracture, dislocation, and acute gastroenteritis.

[0035] Among them, safflower is the dried flower of Carthamus tinctorius L., a plant of the Asteraceae family. It has the effects of promoting blood circulation and menstruation, dispersing blood stasis and relieving pain. It is used for amenorrhea, dysmenorrhea, lochia retention, masses, injuries from falls, and swelling and pain in sores.

[0036] Among them, cinnamon is the dried young branches of Cinnamomum cassia Presl, a plant of Lauraceae. It has the effects of sweating and relieving muscles, warming and unblocking meridians, promoting yang and transforming qi, and balancing and descending qi. It is used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0037] Among them, white mustard seeds are the seeds of the cruciferous plant white mustard. It has the effects of promoting qi and eliminating phlegm, warming the middle and dispersing cold, unblocking meridians and relieving pain. It can treat phlegm and cough, chest and flank distension and pain, nausea and vomiting, aphasia due to stroke, numbness and pain in limbs, beriberi, genital carbuncle, swelling and pain, and swelling and pain from falls.

[0038] Among them, Qingfengteng is the dried vine stems of Sinomenium acutum (Thunb.) Rehd et Wils. and inomenium acutum (Thunb.) Rehd. et Wils. var. cinereum Rehd. et Wils. of the Menispermaceae family. It has the effects of removing rheumatism, unblocking meridians, and promoting urination. It is used for rheumatic pain, joint swelling, paralysis and itching.

[0039] Among them, the black snake is the whole body of the black-banded snake of the Colubridae family without the internal organs. It has the effect of removing rheumatism and unblocking the meridians. It can treat rheumatism, skin numbness, bone and joint tuberculosis, measles, scabies, leprosy, tetanus, and poliomyelitis.

[0040] The centipede is the dried body of Scolopendra subspinipes mutilans L. Koch, an animal of the Scolopendae family. It has the effects of calming wind and relieving spasm, dispersing toxicity and relieving pain. It is used for infantile convulsions, convulsions and spasms, crooked mouth due to stroke, hemiplegia, tetanus, rheumatism, sores, scrofula, and snake bites.

[0041] Camphor is a granular crystal obtained by distilling the roots, branches, leaves and waste materials of Cinnamomum camphora (L.) Presl. of the Lauraceae family. It has the effects of clearing the orifices and eliminating filth, warming the middle and relieving pain, and removing dampness and killing insects. It is used for vomiting and diarrhea caused by cold and dampness, stomach and abdominal pain; it is used externally to treat scabies, ringworm, and tooth decay pain.

[0042] Among them, myrrh is the oily resin exuded from the bark of the trunk of Commiphora myrrha Engl. [C. molmolEngl.] and other plants of the same genus in the Oleaceae family. It has the effects of dispersing blood and removing blood stasis, reducing swelling and relieving pain. It can treat falls, wounds, tendons and bones, heart and stomach pains, masses, amenorrhea, swelling and pain in carbuncle, hemorrhoid fistula, and eye disorders.

[0043] Among them, Buza leaves are leaves of Microcos paniculata., a plant of the Tiliaceae family. It has the effects of clearing away heat, digesting food, and resolving phlegm. It is used for colds, heatstroke, food stagnation, indigestion, and diarrhea.

[0044] Among them, frankincense is a plant of the genus Boswellia in the family Oleaceae, including the frankincense tree Boswellia carterii Birdw. [B. sacraFluek.], the medicinal gum tree B. bhawdajiana Birdw., and the wild frankincense tree B. neglecta M. Moore. Its oleoresin exuded from wounds on the bark of its trunk is used as medicine. It has the effect of promoting blood circulation and relieving pain. It is used for various pains in the heart and abdomen, muscle spasms, injuries from falls, swelling and pain in sores and carbuncles; it can be used externally to reduce swelling and promote tissue regeneration.

[0045] Among them, the dried aerial part of Schizonpeta tenuifolia Briq. of the Labiatae family has the effects of dispelling wind and clearing rashes. It is used for colds, headaches, measles, rubella, and the initial stage of sores. Stir-fried charcoal can treat bloody stools, metrorrhagia, and postpartum blood loss.

[0046] The beneficial effects of the present invention are as follows: Traditional Chinese medicine believes that synovitis and tenosynovitis belong to the category of "arthralgia" in traditional Chinese medicine, and the clinical treatment principles are generally to remove dampness and arthralgia, dredge collaterals and relieve pain, relax muscles and tendons, activate blood circulation, and warm and dredge meridians. The external Chinese medicine composition involved in the present invention uses Pittosporum tobira bark, Campsis creeper and Clematis chinensis as main drugs, which can dispel wind and dampness, relax muscles and tendons, cool blood and remove blood stasis, and detoxify and reduce swelling; uses Chuanxiong, processed Chuanwu, Pulsatilla scabra, Herba Polygoni Multiflori, Leaf of Buza and Rhubarb as assistant drugs, which can dispel wind and dampness, warm the meridians and relieve pain, and clear away heat and detoxify, and further enhance the effects of the main drugs in dispelling wind, relaxing muscles and tendons, activating blood circulation and relieving pain; uses Rhizoma Dioscoreae, Angelicae Sinensis, Paeonia lactiflora, Herba Schizonepetae, Gleditsia sinensis, Cinnamomum cassia, Angelica dahurica, Radix Ampelopsis, Olibanum, Myrrh and Fructus Forsythiae as adjuvant drugs, uses Fructus Achyranthis Bidentatae, Carthamus tinctorius, Semen Sinapis, Caulis Sinensis, Snake, Centipede and Camphor as guiding drugs, which can coordinate the effects of dispelling wind and promoting blood circulation, tonifying the kidney and strengthening tendons, and further have the effects of removing dead tissue, promoting tissue regeneration, reducing swelling and relieving pain, promoting diuresis and reducing swelling, and strengthening muscles and tendons. The combination of these medicines has the effects of removing dampness and numbness, dredging meridians and relieving pain, relaxing muscles and tendons, activating blood circulation, warming the meridians, and anti-inflammatory and analgesic. It has a very significant therapeutic effect on synovitis and tenosynovitis. DETAILED DESCRIPTION

[0047] In order to better understand the present invention, the embodiments of the present invention are described in detail below in conjunction with examples. However, those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention.

[0048] Embodiment 1:

[0049] A traditional Chinese medicine composition for external use for treating synovitis and tenosynovitis, comprising the following raw materials: 30 parts of processed Chuanwu, 30 parts of Chuanxiong, 25 parts of rhubarb, 25 parts of Rhizoma Dioscoreae, 30 parts of Pittosporum tobira, 30 parts of Angelica sinensis, 20 parts of red peony root, 20 parts of Angelica dahurica, 20 parts of Bletilla striata, 20 parts of Forsythia suspensa, 20 parts of Semen Codonopsis pilosulae, 30 parts of Clematidis, 25 parts of Pulsatilla scutellariae, 15 parts of Gleditsia sinensis, 15 parts of Herba Polygoni Multiflori, 30 parts of Campsis creeper, 25 parts of Carthamus tinctorius, 25 parts of Cinnamomum officinale, 20 parts of Sinapis alba, 20 parts of Caulis Sinensis, 25 parts of Snakehead acutus, 12 parts of Scolopendra subspinipes, 12 parts of Camphor, 20 parts of Myrrha, 30 parts of Buza leaves, 20 parts of Olibanum incense and 20 parts of Schizonepeta tenuifolia.

[0050] A method for preparing the external Chinese medicine composition comprises the following steps:

[0051] S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use;

[0052] S2. Take the Chinese medicine powder obtained in step S1, add 12 times the weight of the powder in an amount of 80% ethanol solution, ultrasonically extract for 6h, filter and obtain the filtrate and residue, and set aside;

[0053] S3. Weigh angelica dahurica, white peony root, forsythia suspensa, wood beetle, clematis, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, vine, black snake, centipede, camphor, myrrh, slag leaf, frankincense by weight, grind into coarse powder, add 85% ethanol solution 3 times the weight of the coarse powder to soak for 3 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into a percolator with absorbent cotton at the bottom in 3 times, and then load the filter residue obtained in step S2 in 2 times, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 6 h, collect the percolate and set aside;

[0054] S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 60% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution;

[0055] S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

[0056] Embodiment 2:

[0057] A traditional Chinese medicine composition for external use for treating synovitis and tenosynovitis, composed of the following raw materials: 10 parts of processed Chuanwu, 10 parts of Chuanxiong, 5 parts of rhubarb, 5 parts of Rhizoma Dioscoreae, 10 parts of Pittosporum tobira bark, 10 parts of Angelica sinensis, 3 parts of red peony root, 3 parts of Angelica dahurica, 3 parts of Bletilla striata, 10 parts of Forsythia suspensa, 3 parts of Semen Corydalis, 10 parts of Clematidis, 5 parts of Pulsatilla scutellariae, 5 parts of Gleditsia sinensis, 5 parts of Herba Polygoni Multiflori, 10 parts of Campsis creeper, 5 parts of Carthamus tinctorius, 5 parts of Cinnamomum officinale, 5 parts of Sinapis alba, 5 parts of Caulis Sinensis, 5 parts of Caulis Sinensis, 5 parts of Snakehead aconite, 3 parts of Scolopendra subspinipes, 3 parts of Camphor, 5 parts of Myrrha, 15 parts of Buza leaves, 5 parts of frankincense and 5 parts of Vitex schizonepetae.

[0058] A method for preparing the external Chinese medicine composition comprises the following steps:

[0059] S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use;

[0060] S2. Take the Chinese medicine powder obtained in step S1, add 80% ethanol solution 5 times the weight of the powder, ultrasonically extract for 1.5h, filter to obtain the filtrate and residue, and set aside;

[0061] S3. Weigh angelica dahurica, white peony root, forsythia suspensa, wood beetle, clematis root, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, qingfengteng, black snake, centipede, camphor, myrrh, slag leaf, frankincense by weight, grind into coarse powder, add 85% ethanol solution twice the weight of the coarse powder to soak for 1 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into the percolator with absorbent cotton at the bottom in 2 times, and then load the filter residue obtained in step S2 in 1 time, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 2 h, collect the percolate and set aside;

[0062] S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 40% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution;

[0063] S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

[0064] Embodiment 3:

[0065] A Chinese medicine composition for external use for treating synovitis and tenosynovitis, comprising the following raw materials: 20 parts of processed Chuanwu, 20 parts of Chuanxiong, 15 parts of rhubarb, 10 parts of Rhizoma Dioscoreae, 25 parts of Pittosporum tobira bark, 22 parts of angelica, 11 parts of red peony root, 13 parts of angelica dahurica, 9 parts of white ampel, 11 parts of forsythia, 8 parts of pygmy schizonepeta, 25 parts of clematis, 17 parts of Pulsatilla, 6 parts of Gleditsia sinensis, 11 parts of Radix schizonepetae, 25 parts of Campsis creeper, 8 parts of safflower, 10 parts of cinnamon bark, 7 parts of white mustard seeds, 15 parts of Caulis Aconiti Lateralis, 13 parts of black snake, 4 parts of Scolopendra subspinipes, 5 parts of camphor, 11 parts of myrrh, 26 parts of Buza leaves, 11 parts of frankincense and 6 parts of schizonepeta.

[0066] A method for preparing the external Chinese medicine composition comprises the following steps:

[0067] S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use;

[0068] S2. Take the Chinese medicine powder obtained in step S1, add 7 times the weight of the powder to 80% ethanol solution, ultrasonically extract for 4.5 h, filter to obtain the filtrate and residue, and set aside;

[0069] S3. Weigh angelica dahurica, white peony root, forsythia, wood beetle, clematis, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, vine, black snake, centipede, camphor, myrrh, slag leaf, frankincense by weight, grind into coarse powder, add 85% ethanol solution twice the weight of the coarse powder and soak for 2.5 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into the percolator with absorbent cotton at the bottom in 3 times, and then load the filter residue obtained in step S2 in 2 times, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 3.5 h, collect the percolate and set aside;

[0070] S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 45% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution;

[0071] S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

[0072] Embodiment 4:

[0073] A Chinese medicine composition for external use for treating synovitis and tenosynovitis, comprising the following raw materials: 28 parts of processed Chuanwu, 14 parts of Chuanxiong, 15 parts of rhubarb, 16 parts of Rhizoma Dioscoreae, 28 parts of Pittosporum tobira bark, 22 parts of angelica, 11 parts of red peony root, 6 parts of angelica dahurica, 6 parts of white ampel, 14 parts of forsythia, 11 parts of pygmy schizonepeta, 28 parts of clematis, 14 parts of Pulsatilla scabra, 9 parts of Gleditsia sinensis, 10 parts of Radix schizonepetae, 28 parts of Campsis creeper, 14 parts of safflower, 17 parts of cinnamon bark, 14 parts of mustard seeds, 16 parts of Caulis Sinapis, 10 parts of snakehead, 6 parts of Scolopendra subspinipes, 7 parts of camphor, 15 parts of myrrh, 20 parts of Buza leaves, 15 parts of frankincense and 11 parts of schizonepeta.

[0074] A method for preparing the external Chinese medicine composition comprises the following steps:

[0075] S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use;

[0076] S2. Take the Chinese medicine powder obtained in step S1, add 11 times the weight of the powder to 80% ethanol solution, ultrasonically extract for 5.5 h, filter to obtain the filtrate and residue, and set aside;

[0077] S3. Weigh angelica dahurica, white peony root, forsythia suspensa, wood beetle, clematis, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, vine, black snake, centipede, camphor, myrrh, slag leaf, frankincense by weight, grind into coarse powder, add 85% ethanol solution 3 times the weight of the coarse powder to soak for 2 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into the percolator with absorbent cotton at the bottom in 2 times, and then load the filter residue obtained in step S2 in 2 times, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 5.5 h, collect the percolate and set aside;

[0078] S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 55% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution;

[0079] S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

[0080] Embodiment 5:

[0081] A Chinese medicine composition for external use for treating synovitis and tenosynovitis, comprising the following raw materials: 30 parts of processed Chuanwu, 22 parts of Chuanxiong, 12 parts of rhubarb, 18 parts of Rhizoma Dioscoreae, 30 parts of Pittosporum tobira, 25 parts of Angelica sinensis, 12 parts of red peony root, 10 parts of Angelica dahurica, 10 parts of Bletilla striata, 15 parts of Forsythia suspensa, 12 parts of Semen Armeniacae Atractylodes, 25 parts of Clematidis, 17 parts of Pulsatilla scutellariae, 9 parts of Gleditsia sinensis, 10 parts of Herba Polygoni Multiflori, 30 parts of Campsis Creeper, 20 parts of Carthamus tinctorius, 15 parts of Cinnamomum officinale, 10 parts of Sinapis alba, 10 parts of Caulis Sinensis, 14 parts of Snakehead aconite, 8 parts of Scolopendra subspinipes, 6 parts of Camphor, 13 parts of Myrrha, 22 parts of Buza leaves, 15 parts of Olibanum incense and 15 parts of Vitex schizonepetae.

[0082] A method for preparing the external Chinese medicine composition comprises the following steps:

[0083] S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use;

[0084] S2. Take the Chinese medicine powder obtained in step S1, add 8 times the weight of the powder to 80% ethanol solution, ultrasonically extract for 3.5 h, filter to obtain the filtrate and residue, and set aside;

[0085] S3. Weigh angelica dahurica, white peony root, forsythia suspensa, wood beetle, clematis, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, vine, black snake, centipede, camphor, myrrh, slag leaf, frankincense by weight, grind into coarse powder, add 85% ethanol solution 3 times the weight of the coarse powder to soak for 2.5 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into the percolator with absorbent cotton at the bottom in 3 times, and then load the filter residue obtained in step S2 in 2 times, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 4h, collect the percolate and set aside;

[0086] S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 50% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution;

[0087] S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

[0088] Example 6: Effect of the external Chinese medicine composition of the present invention on synovial inflammation in rats with arthritis induced by type II collagen

[0089] (1) Experimental animals: 30 clean-grade Wistar rats, male, 2-3 months old, weighing 180-220 g, purchased from Shanghai Slake Laboratory Animal Co., Ltd.

[0090] (2) Experimental groups and methods: 36 rats were randomly divided into 5 groups, 6 rats in each group, namely normal group, model group, low-dose treatment group, medium-dose treatment group, and high-dose treatment group. Bovine type II collagen was dissolved in 0.1 mmol / L acetic acid and mixed with Freund's complete adjuvant at a ratio of 2 mg / ml in a 1:1 ratio for emulsification. Except for the normal group, it was injected at the base of the tail of rats in the remaining groups (0.2 mL per injection per rat). Arthritis was induced 11-16 days after collagen immunization, and the inflammation lasted for 3-4 weeks after onset. Drug administration began on the 10th day after modeling. Before drug administration, the abdomen and legs of rats in the normal group, model group, low-dose treatment group, medium-dose treatment group, and high-dose treatment group were depilated. The depilatory range of the abdomen was about 2×3 cm 2, the rats were administered with the external Chinese medicine composition prepared in Example 5 at a dosage of 1.0 g / kg, 2.0 g / kg, and 4.0 g / kg, respectively, in the low-dose treatment group, the medium-dose treatment group, and the high-dose treatment group. The normal group and the model group were given 4.0 g / kg of normal saline, which was applied to the ankle joints and the depilated part of the abdomen of each rat to allow it to be fully absorbed. The administration was continued for 10 days, once in the morning and evening each day. One hour after the last administration, the rats were decapitated, the joint synovium was separated, and the synovium was subjected to HE pathological sections to determine the effects on inflammatory cell infiltration, macrophage A cell proliferation, and synovial hyperplasia.

[0091] (3) Experimental results: The experimental results are shown in Table 1. The low, medium and high doses of the external Chinese medicine composition of the present invention have obvious inhibitory effects on the proliferation of synovial macrophage type A cells and synovial hyperplasia, and the high dose group has the best effect.

[0092] Table 1 Effects on pathological scores of synovial inflammation in arthritis rats (mean ± SD, n = 6)

[0093]

[0094] Note: Compared with the blank group, #P <0.05, ##P <0.01; compared with the model group, *P <0.05, **P <0.01.

[0095] Example 7: Clinical therapeutic effect of the external Chinese medicine composition of the present invention on finger tenosynovitis

[0096] (1) General information: From June to December 2022, 50 patients with finger tenosynovitis were selected. Among them, there were 10 males and 40 females; the oldest was 69 years old and the youngest was 13 years old, with an average age of (45.80±9.63) years old; the course of disease ranged from 1 to 45 months, with an average course of disease of (10.02±6.75) months.

[0097] (2) Diagnostic criteria: refer to the "Standards for Diagnosis and Efficacy of TCM Diseases and Syndromes" issued by the State Administration of Traditional Chinese Medicine in 1994 and "Practical Orthopedics" published by Li Maohua et al. in 2016. Grading criteria: refer to "Clinical Pain Treatment Technology". Inclusion criteria: 1. Meet the diagnostic criteria for finger tenosynovitis; 2. Age ≥ 12 years old; 3. No acupuncture, blockade, small needle knife, wax therapy or other related treatments in the past month; 4. The patient and family members have been informed of the pros and cons of participating in this study and signed the informed consent. Exclusion criteria: 1. Pregnant or lactating women; 2. Patients with infectious diseases and coagulation disorders; 3. Patients who are allergic to the drugs used in this study; 4. Patients with severe cardiovascular and cerebrovascular diseases.

[0098] (3) Treatment method: The 50 patients were randomly divided into two groups according to the severity of tenosynovitis, with 25 people in each group, recorded as the control group and the experimental group. The control group took Du Yiwei capsules orally, 3 capsules at a time, 3 times a day, and 7 days as a course of treatment. The experimental group was given the external use composition prepared in Example 5 of the present application, applied to the affected area, once in the morning and evening every day, for 7 consecutive days, as a course of treatment.

[0099] (4) Observation indicators:

[0100] 1) Assessment of pain intensity: The visual analogue scale (VAS) was used to assess the pain intensity of the patients. A 10 cm horizontal line was drawn on a piece of paper, with 0 at one end, indicating no pain, and 10 at the other end, indicating the maximum degree of unbearable pain. The patients were asked to mark the horizontal line according to their own feelings to indicate the degree of their pain. The results are shown in Table 2.

[0101] Table 2 Comparison of VAS scores of two groups of patients with finger sheath inflammation before and after treatment (mean ± standard deviation)

[0102]

[0103] Note: Compared with before treatment, #P <0.05, ##P <0.01; compared with control group, *P <0.05, **P <0.01.

[0104] 2) Efficacy evaluation criteria: The criteria for evaluating the efficacy of finger tenosynovitis in Practical Orthopedics and TCM Disease Diagnosis and Efficacy Criteria were formulated. The efficacy of the two groups of patients was evaluated during follow-up after two courses of treatment. Cured: The pain of the affected finger completely disappeared, the flexion and extension of the metacarpophalangeal joint was normal, and there was no snapping or locking phenomenon; Improved: The pain of the affected finger basically disappeared, the tenderness was reduced compared with before, and there was snapping during the flexion and extension of the metacarpophalangeal joint, but there was no locking phenomenon; Ineffective: The symptoms of the affected finger were not improved. Total effective rate = (number of cured cases + number of improved cases) / total number of cases * 100%, cure rate = number of cured cases / total number of cases * 100%. The results are shown in Table 3.

[0105] Table 3 Comparison of clinical efficacy between the two groups of patients with finger sheath inflammation (cases (%))

[0106]

[0107] It can be seen from Tables 2 and 3 that compared with the control group, the VAS score of the experimental group was significantly reduced after treatment, and the total effective rate was higher, indicating that the external Chinese medicine composition of the present invention has a good therapeutic effect on finger tenosynovitis.

[0108] In summary, it can be seen from the experimental results that the low, medium and high dose groups of the external Chinese medicine composition of the present invention all have significant therapeutic effects on synovitis and tenosynovitis, indicating that the external Chinese medicine composition of the present invention has definite anti-inflammatory, detumescent and analgesic effects, can be used to treat synovitis and tenosynovitis, and is easy to use.

[0109] The applicant declares that the present invention illustrates the external Chinese medicine composition for treating synovitis and tenosynovitis and the preparation method thereof through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0110] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0111] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A Chinese medicine composition for external use for treating synovitis and tenosynovitis, characterized in that: The invention is composed of the following raw materials: 10-30 parts of processed Chuanwu, 10-30 parts of Chuanxiong, 5-25 parts of rhubarb, 5-25 parts of Rhizoma Dioscoreae, 10-30 parts of Pittosporum tobira bark, 10-30 parts of Angelica sinensis, 3-20 parts of red peony root, 3-20 parts of angelica dahurica, 3-20 parts of white smilax, 10-20 parts of forsythia, 3-20 parts of pygmy schizonepeta, 10-30 parts of clematis, 5-25 parts of Pulsatilla scutellariae, 5-15 parts of Gleditsia sinensis, 5-15 parts of Radix Angelicae Pubescentis, 10-30 parts of Campsis grandiflora, 5-25 parts of safflower, 5-25 parts of cinnamon bark, 5-20 parts of white mustard seeds, 5-20 parts of clematis quinata, 5-25 parts of black snake, 3-12 parts of centipede, 3-12 parts of camphor, 5-20 parts of myrrh, 15-30 parts of Buza leaves, 5-20 parts of frankincense and 5-20 parts of schizonepeta.

2. The external Chinese medicine composition according to claim 1, characterized in that: The invention is composed of the following raw materials: 15-30 parts of processed Chuanwu, 15-25 parts of Chuanxiong, 10-20 parts of rhubarb, 10-25 parts of Rhizoma Dioscoreae, 15-30 parts of Pittosporum tobira bark, 15-25 parts of Angelica sinensis, 5-15 parts of red peony root, 5-15 parts of Angelica dahurica, 5-15 parts of white smilax, 12-18 parts of Forsythia suspensa, 5-15 parts of Fructus Aconiti Lateralis, 15-30 parts of Clematis chinensis, 10-25 parts of Pulsatilla suspensa 1-20 parts, 7-15 parts of Gleditsia sinensis, 7-15 parts of Herba spatholobi, 15-30 parts of Flos Campsis, 10-22 parts of Flos Carthami, 10-22 parts of Cassia twigs, 7-18 parts of Semen Sinapis, 7-18 parts of Caulis Sinapis, 10-25 parts of Snakes, 5-10 parts of Scolopendra subspinipes, 5-10 parts of Camphor, 8-18 parts of Myrrh, 20-25 parts of Folium Buza, 10-20 parts of Olibanum, and 10-20 parts of Semen Viscum.

3. The external Chinese medicine composition according to claim 2, characterized in that: The invention is composed of the following raw materials: 30 parts of processed Chuanwu, 22 parts of Chuanxiong, 12 parts of Rhubarb, 18 parts of Rhizoma Dioscoreae, 30 parts of Pittosporum tobira, 25 parts of Angelica sinensis, 12 parts of Red Peony Root, 10 parts of Angelica dahurica, 10 parts of Bletilla striata, 15 parts of Forsythia suspensa, 12 parts of Semen Corydalis, 25 parts of Clematidis, 17 parts of Pulsatilla scutellariae, 9 parts of Gleditsia sinensis, 10 parts of Herba Polygoni Multiflori, 30 parts of Campsis Creeper, 20 parts of Carthamus tinctorius, 15 parts of Cinnamomum officinale, 10 parts of Semen Sinapis, 10 parts of Caulis Sinensis, 14 parts of Snakehead Snake, 8 parts of Scolopendra subspinipes, 6 parts of Camphor, 13 parts of Myrrha, 22 parts of Buza Leaf, 15 parts of Olibanum and 15 parts of Vitex.

4. A method for preparing the external Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Weigh by weight the processed Chuanwu, Chuanxiong, rhubarb, Rhizoma Cistanches, Pittosporum tobira, Angelica, Paeonia lactiflora, Gleditsia sinensis, Guiji, and Jingjie, and use a grinder to crush the above Chinese medicinal materials into powder, sieve through 100 mesh to obtain powder for later use; S2. Take the Chinese medicine powder obtained in step S1, add 80% ethanol solution 5-12 times the weight of the powder, ultrasonic extraction 1-6h, filter to obtain the filtrate and residue, set aside; S3. Weigh angelica dahurica, white peony root, forsythia, wood beetle, clematis, white peony root, radix pedunculi, trumpet creeper, safflower, white mustard, vine, black snake, centipede, camphor, myrrh, cloth residue leaf, frankincense by weight fraction, grind into coarse powder, add 85% ethanol solution 2-3 times the weight of the coarse powder and soak for 1-3 h, so that the coarse powder of the medicinal materials is fully expanded, and then evenly load it into the percolator with absorbent cotton at the bottom in 2-3 times, and then load the filter residue obtained in step S2 in 1-2 times, press it with a wooden stick after each loading, and then slowly add 85% ethanol solution from the upper part of the percolator, percolate and extract for 2-6 h, collect the percolate and set aside; S4. The filtrate obtained in step S2 and the percolate obtained in step S3 are combined, concentrated by heating to 40-60% of the original volume, filtered, and cooled to room temperature to obtain a concentrated solution; S5. The concentrated medicinal solution obtained in step S4 is divided into 100 ml glass medicinal wine bottles and sterilized by ultraviolet light to obtain the external Chinese medicine composition.

5. The method for preparing the external Chinese medicine composition according to claim 4, characterized in that: The amount of ethanol solution used in step S2 is 8 times, and the extraction time is 3.5 h.

6. The method for preparing the external Chinese medicine composition according to claim 4, characterized in that: The percolation extraction time in step S3 is 4 h, and the concentrated volume in step S4 is 50% of the original volume.

7. Use of the external Chinese medicine composition according to any one of claims 1 to 3 or the external Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 6 in preparing a medicament for treating synovitis and tenosynovitis.

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