Acetamido-phenyltetrazole derivatives and their usage

Abstract

This invention relates to compounds of formula (IA), as well as their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods of preparation. The compounds disclosed herein can be used to treat diseases in which P-glycoprotein and / or cytochrome P450 (e.g., CYP3A4) are regulated (e.g., cancers that have developed multidrug resistance).

Description

[0001] Related applications

[0002] This application claims priority and interest in U.S. Provisional Application No. 63 / 088,788, filed October 7, 2020, the entire contents of which are incorporated herein by reference. Technical Field

[0003] This invention relates to acetamido-phenyltetrazole derivatives having P-glycoprotein regulatory activity and / or regulatory activity against drug-metabolizing enzymes cytochrome P450 (e.g., CYP3A4 and / or CYP3A5 isoforms), and for use in treating humans or animals. This disclosure also relates to methods for preparing these compounds, pharmaceutical compositions comprising them, and their use in treating diseases in which the expression of P-glycoprotein and / or cytochrome P450 isoforms (e.g., CYP3A4 or CYP3A5) is regulated (e.g., in cancers that have developed multidrug resistance). This disclosure further relates to the use of the compounds of this disclosure for improving the oral bioavailability of therapeutic agents that are substrates of P-glycoprotein and / or cytochrome P450. This disclosure also relates to the use of the compounds of this disclosure for increasing the brain distribution of therapeutic agents that are substrates of P-glycoprotein and / or cytochrome P450. Background Technology

[0004] Many anticancer drugs (such as vinca alkaloids, anthracyclines, epipodophyllotoxin, paclitaxel, and docetaxel) become ineffective when administered to patients with multidrug resistance (MDR), which is caused by the presence of overexpressed P-glycoproteins. P-glycoproteins regulate the intracellular accumulation of administered anticancer drugs by pumping them out of tumor cells. The expression of the drug-metabolizing protein CYP3A4 in breast, colorectal, esophageal tumors, and Ewing's sarcoma may inhibit the intracellular concentration of anticancer drugs by forming metabolites with reduced antitumor activity. This role of CYP3A4 limits the efficacy of anticancer drugs or leads to resistance to these drugs. Regulation of P-glycoproteins and / or cytochrome P450 enzymes (such as CYP3A4) in tumor cells can increase the sensitivity of these cells to anticancer drugs.

[0005] P-glycoproteins are also expressed in normal healthy tissues, such as the small intestine. Intestinal P-glycoproteins prevent their substrates from crossing the epithelial cells of the intestinal wall, resulting in poor oral bioavailability of these substrates. Furthermore, anticancer agents may also suffer first-pass metabolism by cytochrome P450 enzymes (e.g., CYP3A4 and / or CYP3A5 isoforms) present in the small intestine and liver, further reducing their oral bioavailability. Therefore, it is necessary to improve the bioavailability of anticancer agents through dual-targeted regulation of P-glycoproteins and cytochrome P450 enzymes (e.g., CYP3A4 and / or CYP3A5 isoforms).

[0006] The localization of P-glycoproteins in the endothelial cells of the blood-brain barrier significantly restricts the transport of P-glycoprotein substrates from the blood to the brain. Modulation of P-glycoproteins at the blood-brain barrier may be beneficial for the treatment of many central nervous system (CNS) diseases, such as brain tumors like glioblastoma. Traditional P-glycoprotein modulators, such as verapamil and cyclosporine A, can cause serious side effects (e.g., hypotension and immunosuppression). Therefore, several novel P-glycoprotein modulators have been developed, such as piperidine-2-carboxylic acid esters, acridine, piperazine-2,5-dione, anthranilic acid, and methylene dibenzocycloheptane derivatives. However, newly introduced P-glycoprotein modulators have been reported to have toxicity and other side effects. This disclosure stems from the need to provide other compounds for regulating P-glycoprotein and cytochrome P450 (e.g., CYP3A4 and CYP3A5 isoforms) enzymes, said compounds reducing serious side effects while a) significantly improving the bioavailability of substrates of these enzymes, including anticancer agents, b) overcoming multidrug resistance in tumors, and c) improving the delivery of P-glycoprotein substrates to the brain. Summary of the Invention

[0007] In one aspect, the present invention provides compounds of formula (IA):

[0008]

[0009] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0010] A is C 3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 14-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-group;

[0011] Each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0012] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0013] Each R2 and R3 is independently H and C.2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0014] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0015] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0016] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0017] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0018] Each R9 is independently -(CH2) u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0019] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0020] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups.3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0021] Two Rs 11 The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0022] Each of n, m, and p is independently 0 or 1;

[0023] t is 1, 2, or 3; and

[0024] u can be 0, 1, 2, or 3.

[0025] When R5 and R6, together with the atoms they are attached to, form a heterocyclic or heteroaryl group that substitutes for two R7 groups, and both R7 groups are -O-methyl, then

[0026] (a) One of R2 and R3 is not -O-methyl; or

[0027] (b)R x or R y It is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0028] In one aspect, the present invention provides compounds of formula (I):

[0029]

[0030] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0031] A is C 3-10Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl or 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-group;

[0032] Each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0033] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0034] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0035] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0036] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0037] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0038] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0039] Each R9 is independently -(CH2) u-(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0040] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0041] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0042] Two Rs 11 The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0043] Each of n, m, and p is independently 0 or 1;

[0044] t is 1, 2, or 3; and

[0045] u can be 0, 1, 2, or 3.

[0046] When R5 and R6 together with the atoms they are attached to form a heterocyclic or heteroaryl group that has two R7s, then one of the R7s is not -O-methyl.

[0047] In one aspect, the present invention provides compounds of formula (I'):

[0048]

[0049] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0050] A is

[0051] Each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0052] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0053] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0054] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0055] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0056] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0057] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0058] Each R9 is independently -(CH2) u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0059] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0060] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0061] Two Rs 11The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0062] Each of n, m, and p is independently 0 or 1;

[0063] t is 1, 2, or 3; and

[0064] u can be 0, 1, 2, or 3.

[0065] When R5 and R6 together with the atoms they are attached to form a heterocyclic or heteroaryl group that has two R7s, then one of the R7s is not -O-methyl.

[0066] In one aspect, the present invention provides compounds of formula (II):

[0067]

[0068] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0069] R x For H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0070] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0071] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11-C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0072] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0073] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0074] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0075] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0076] Each R9 is independently -(CH2) u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0077] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0078] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0079] Two Rs 11 The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0080] Each of n, m, and p is independently 0 or 1;

[0081] t is 1, 2, or 3; and

[0082] u can be 0, 1, 2, or 3.

[0083] When R5 and R6 together with the atoms they are attached to form a heterocyclic or heteroaryl group that has two R7s, then one of the R7s is not -O-methyl.

[0084] In one aspect, the present invention provides compounds of formula (IA'):

[0085]

[0086] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0087] A is C 3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl or 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-group;

[0088] Each R x and R y Independently H or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S;

[0089] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0090] Each of R2 and R3 is independently H, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 Alkyne group, or -O- (a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0091] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0092] Each R7 is independently C 1-6 alkoxy groups; and

[0093] Each of n, m, and p is independently 0 or 1.

[0094] Where (a) one of R2 and R3 is not -O-methyl; or (b) R x or R y It is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0095] In one aspect, the present invention provides a compound which can be obtained by or through methods for preparing the compounds described herein (e.g., methods comprising one or more steps described in embodiments 1-6).

[0096] In one aspect, the present invention provides pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers or salts thereof, and pharmaceutically acceptable diluents or carriers.

[0097] In one aspect, this disclosure provides intermediates as described herein, which are suitable for use in methods of preparing compounds as described herein (e.g., the intermediates are selected from those described in Examples 1-16).

[0098] In one aspect, the present invention provides a method for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo), comprising contacting cells with an effective amount of the compound of the present invention or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof.

[0099] In one aspect, the present invention provides a method for treating or preventing the diseases or disorders disclosed herein in a subject in need, comprising administering to the subject a therapeutically effective amount of a compound of the present invention or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, or a pharmaceutical composition of the present invention.

[0100] In one aspect, the present invention provides compounds of the present invention or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers or salts thereof for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo).

[0101] In one aspect, the present invention provides compounds of the present invention or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers or salts thereof for the treatment or prevention of the diseases or disorders disclosed herein.

[0102] In one aspect, the present invention provides the use of the compounds of the present invention or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers or salts thereof in the preparation of medicaments for modulating P-glycoprotein activity (e.g., in vitro or in vivo) and / or cytochrome P450 activity (e.g., in vitro or in vivo).

[0103] In one aspect, the present invention provides the use of the compounds of the present invention or pharmaceutically acceptable prodrugs, solvates, enantiomers, stereoisomers, tautomers or salts thereof in the preparation of medicaments for the treatment or prevention of the diseases or disorders disclosed herein.

[0104] On one hand, the present invention provides a method for preparing the compound of the present invention.

[0105] On the one hand, the present invention provides a method for preparing a compound, comprising one or more steps described herein.

[0106] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains. In the specification, singular forms also include plural forms unless the context clearly specifies otherwise. Although methods and materials similar to or equivalent to those described herein may be used in practice or testing with this disclosure, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated herein by reference. References cited herein are not considered prior art to the claimed invention. In case of conflict, this specification, including the definitions, shall prevail. Furthermore, materials, methods, and examples are illustrative only and not restrictive. In case of conflict between the chemical structures and names of the compounds disclosed herein, the chemical structure shall prevail.

[0107] Other features and advantages of the invention will become apparent from the following detailed description and claims. Invention Details

[0109] The compounds of the present invention

[0110] In one aspect, the present invention provides compounds of formula (IA):

[0111]

[0112] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0113] A is C 3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl or 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-group;

[0114] Each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0115] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0116] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0117] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0118] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0119] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0120] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0121] Each R9 is independently -(CH2) u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0122] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0123] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0124] Two Rs 11 The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0125] Each of n, m, and p is independently 0 or 1;

[0126] t is 1, 2, or 3; and

[0127] u can be 0, 1, 2, or 3.

[0128] When R5 and R6, together with the atoms they are attached to, form a heterocyclic or heteroaryl group that substitutes for two R7 groups, and both R7 groups are -O-methyl, then

[0129] (a) One of R2 and R3 is not -O-methyl; or

[0130] (b)R x or R y It is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0131] In one aspect, the present invention provides compounds of formula (I):

[0132]

[0133] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0134] A is C3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl or 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-group;

[0135] Each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0136] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0137] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0138] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0139] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0140] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0141] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0142] Each R9 is independently -(CH2) u-(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0143] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0144] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0145] Two Rs 11 The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0146] Each of n, m, and p is independently 0 or 1;

[0147] t is 1, 2, or 3; and

[0148] u can be 0, 1, 2, or 3.

[0149] When R5 and R6 together with the atoms they are attached to form a heterocyclic or heteroaryl group that has two R7s, then one of the R7s is not -O-methyl.

[0150] In one aspect, the present invention provides compounds of formula (I'):

[0151]

[0152] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0153] A is

[0154] Each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0155] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0156] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0157] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0158] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0159] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0160] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0161] Each R9 is independently -(CH2) u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0162] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0163] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0164] Two Rs 11The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0165] Each of n, m, and p is independently 0 or 1;

[0166] t is 1, 2, or 3; and

[0167] u can be 0, 1, 2, or 3.

[0168] When R5 and R6 together with the atoms they are attached to form a heterocyclic or heteroaryl group that has two R7s, then one of the R7s is not -O-methyl.

[0169] In one aspect, the present invention provides compounds of formula (II):

[0170]

[0171] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0172] R x For H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S;

[0173] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0174] Each R2 and R3 is independently H and C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11-C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0175] Each R5 and R6 is independently H and C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0176] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0177] Each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 ;

[0178] R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s;

[0179] Each R9 is independently -(CH2) u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2;

[0180] Each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S;

[0181] Each R 11 H and C independently 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more C2 groups. 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more C atoms. 3-10Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, 5- to 10-membered heteroaryl containing 1-4 heteroatoms selected from N, O, and S, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, oxo, halogen, -CN, -OH, or -NH2, or

[0182] Two Rs 11 The atoms bonded to them together form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more C atoms. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 Alkyne, halogen, -CN, -OH, or -NH2;

[0183] Each of n, m, and p is independently 0 or 1;

[0184] t is 1, 2, or 3; and

[0185] u can be 0, 1, 2, or 3.

[0186] When R5 and R6 together with the atoms they are attached to form a heterocyclic or heteroaryl group that has two R7s, then one of the R7s is not -O-methyl.

[0187] In one aspect, the present invention provides compounds of formula (IA'):

[0188]

[0189] Or a pharmaceutically acceptable prodrug, solvate, enantiomer, stereoisomer, tautomer, or salt thereof, wherein:

[0190] A is C 3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl or 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-group;

[0191] Each R x and R y Independently H or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S;

[0192] R1 represents H and C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 alkynyl group;

[0193] Each of R2 and R3 is independently H, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 Alkyne group, or -O- (a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S;

[0194] R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0195] Each R7 is independently C 1-6 alkoxy groups; and

[0196] Each of n, m, and p is independently 0 or 1.

[0197] Where (a) one of R2 and R3 is not -O-methyl; or (b) R x or R y It is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0198] It should be understood that for compounds of formula (IA), (I), (I'), (II) or (IA'), A, R X R Y , R1, R2, R3, R5, R6, R7, R8, R9, R 10 R 11 Where applicable, n, m, p, t, and u can each be selected from the groups described herein, and this document refers to A, R... X R Y , R1, R2, R3, R5, R6, R7, R8, R9, R 10 R 11 Any of the groups described in any of the following can be used with respect to A, R, n, m, p, t, and u, where applicable. X R Y , R1, R2, R3, R5, R6, R7, R8, R9, R 10 R 11 Any combination of one or more of the remaining parts of n, m, p, t and u.

[0199] In some implementations, the N atom of the compound is an N-oxide.

[0200] In some embodiments, the N-oxide has the formula in Indicates the connection with a compound of formula (IA), (I), (I'), (II) or (IA').

[0201] In some embodiments, the N-oxide has the formula in Indicates the connection with a compound of formula (IA), (I), (I'), (II) or (IA').

[0202] In some embodiments, the N-oxide has the formula in Indicates the connection with a compound of formula (IA), (I), (I'), (II) or (IA').

[0203] In some implementations, A is C 3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 14-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxo group.

[0204] In some implementations, A is C 3-10 Cycloalkyl groups, 3- to 14-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 14-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0205] In some implementations, A is C 3-10 Cycloalkyl or a 3- to 14-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with an oxy-type.

[0206] In some implementations, A is C 3-10 Cycloalkyl or 3- to 14-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0207] In some implementations, A is an optional replacement for C in aerobic metabolism. 3-10 Cycloalkyl.

[0208] In some embodiments, A is a C3 cycloalkyl group. In some embodiments, A is a C4 cycloalkyl group. In some embodiments, A is a C5 cycloalkyl group. In some embodiments, A is a C6 cycloalkyl group. In some embodiments, A is a C7 cycloalkyl group. In some embodiments, A is a C8 cycloalkyl group. In some embodiments, A is a C9 cycloalkyl group. In some embodiments, A is a C... 10 Cycloalkyl.

[0209] In some embodiments, A is an optionally substituted C3 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C4 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C5 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C6 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C7 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C8 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C9 cycloalkyl group with an oxygenation. In some embodiments, A is an optionally substituted C... 10 Cycloalkyl.

[0210] In some embodiments, A is a C3-C7 monocyclic cycloalkyl group. In some embodiments, A is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, A is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, A is a C9-C9 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl. In some embodiments, A is C9-C. 10 Bicyclic saturated cycloalkyl group. In some embodiments, A is C9-C. 10 Bicyclic partially saturated cycloalkyl group. In some embodiments, A is C8-C. 10 Polycyclic cycloalkyl groups.

[0211] In some embodiments, A is an optionally substituted, oxygen-modified C3-C7 monocyclic cycloalkyl group. In some embodiments, A is an optionally substituted, oxygen-modified C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, A is an optionally substituted, oxygen-modified C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, A is an optionally substituted, oxygen-modified C9-C7 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl. In some embodiments, A is optionally substituted with an oxygen-dependent C9-C. 10 Bicyclic saturated cycloalkyl. In some embodiments, A is optionally substituted with an oxygen-dependent C9-C. 10 Bicyclic partially saturated cycloalkyl group. In some embodiments, A is an optionally substituted oxy-substituted C8-C. 10 Polycyclic cycloalkyl groups.

[0212] In some embodiments, A is a 3- to 14-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S.

[0213] In some embodiments, A is a 3- to 14-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, optionally substituted with oxygen.

[0214] In some embodiments, A is a 3- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S.

[0215] In some embodiments, A is a 3- to 10-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O, and S, optionally substituted with oxygen.

[0216] In some embodiments, A is a 3-membered heterocyclic group containing one heteroatom selected from N, O, and S. In some embodiments, A is a 4-membered heterocyclic group containing 1-2 heteroatoms selected from N, O, and S. In some embodiments, A is a 5-membered heterocyclic group containing 1-3 heteroatoms selected from N, O, and S. In some embodiments, A is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 14-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S.

[0217] In some embodiments, A is a 3-membered heterocyclic group containing one heteroatom selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is a 4-membered heterocyclic group containing 1-2 heteroatoms selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is a 5-membered heterocyclic group containing 1-3 heteroatoms selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with an oxometalate. In some embodiments, A is a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O and S, optionally substituted with oxygen.

[0218] In some embodiments, A is a 7- to 10-membered bicyclic heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S.

[0219] In some embodiments, A is a 7- to 10-membered bicyclic heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, optionally substituted with oxygen.

[0220] In some embodiments, A is a 7-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S.

[0221] In some embodiments, A is a 7-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with oxygen. In some embodiments, A is an 8-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with oxygen. In some embodiments, A is a 9-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with oxygen. In some embodiments, A is a 10-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S, optionally substituted with oxygen.

[0222] In some embodiments, A is an 8- to 14-membered polycyclic heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S.

[0223] In some embodiments, A is an 8- to 14-membered polycyclic heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, optionally substituted with oxygen.

[0224] In some embodiments, A is an 8- to 10-membered polycyclic heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S.

[0225] In some embodiments, A is an 8- to 10-membered polycyclic heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, optionally substituted with oxygen.

[0226] In some embodiments, A is a 14-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0227] In some embodiments, A is a 14-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O and S, optionally substituted with oxygen.

[0228] In some embodiments, A is a 14-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O and S, which is substituted with oxygen.

[0229] In some implementations, A is C 6-10 Aryl or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0230] In some implementations, A is C 6-10 Aryl. In some embodiments, A is a C5-C6 aryl group. In some embodiments, A is a phenyl group.

[0231] In some embodiments, A is a 5- to 14-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0232] In some embodiments, A is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0233] In some embodiments, A is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is an 11-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 12-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 14-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S.

[0234] In some embodiments, A is a 9- to 10-membered bicyclic heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0235] In some embodiments, A is a 9-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, A is a 10-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0236] In some embodiments, A is a 9- to 10-membered polycyclic heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0237] In some implementation schemes, A is

[0238] In some implementation schemes, A is

[0239] In some implementation schemes, A is

[0240] In some implementation schemes, A is

[0241] In some implementation schemes, A is

[0242] In some implementation schemes, A is

[0243] In some implementation schemes, each R x and R y H and C independently1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0244] In some implementation schemes, each R x and R y H and C independently 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, or -NH2.

[0245] In some implementation schemes, each R x and R y For H.

[0246] In some implementation schemes, each R x and R y Independently for C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0247] In some implementation schemes, each R x and R y Independently for C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, or -NH2.

[0248] In some implementation schemes, each R x and R y Independently, it is a 3- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0249] In some implementation schemes, each R x and R y H and C independently 1-6 Alkyl group or -OH group.

[0250] In some implementation schemes, R x For H, C1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0251] In some implementation schemes, R x For H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, or -NH2.

[0252] In some implementation schemes, R x For H.

[0253] In some implementation schemes, R x C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0254] In some implementation schemes, R x C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, or -NH2.

[0255] In some implementation schemes, R x C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl or C 1-6 Alkyl group.

[0256] In some implementation schemes, R x C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0257] In some implementation schemes, R x C 1-6 Alkyl group. In some embodiments, R x It is methyl. In some embodiments, R xIt is ethyl. In some embodiments, R x It is propyl. In some embodiments, R x For butyl. In some implementations, R x It is pentyl. In some implementations, R x For its own foundation. In some implementation schemes, R x It is isopropyl. In some embodiments, R x It is isobutyl. In some embodiments, R x It is isopentyl. In some embodiments, R x It is an allotropic group. In some implementations, R x It is sec-butyl. In some implementations, R x It is sec-amyl. In some implementations, R x For Zhongjiji. In some implementations, R x It is tert-butyl.

[0258] In some implementation schemes, R x C 2-6 Alkenyl. In some embodiments, R x It is C2-olefinic. In some embodiments, R x It is a C3 alkenyl group. In some embodiments, R x It is a C4 alkenyl group. In some embodiments, R x It is a C5 alkenyl group. In some embodiments, R x It is a C6 alkenyl group.

[0259] In some implementation schemes, R x C 2-6 Alkyne group. In some embodiments, R x It is a C2 acetylene group. In some embodiments, R x It is a C3 acetyl group. In some embodiments, R x It is a C4 acetylene group. In some embodiments, R x It is a C5 acetyl group. In some embodiments, R x It is a C6 acetylene group.

[0260] In some implementation schemes, R x C 1-6 Alkyl group. In some embodiments, R x It is methoxylated. In some embodiments, R x It is ethoxylated. In some embodiments, R x It is propoxylated. In some embodiments, R x It is butoxylated. In some embodiments, R x It is pentoxygenated. In some embodiments, R x It is an hexoxy group.

[0261] In some implementation schemes, R x It can be a halogen, -CN, -OH, or -NH2.

[0262] In some implementation schemes, R x It is a halogen. In some implementations, R x It can be F, Cl, Br, or I. In some implementations, R x It is F, Cl, or Br. In some implementations, R x For F. In some implementations, R x For Cl. In some implementations, R x For Br. In some implementations, R x For I.

[0263] In some implementation schemes, R x For -CN. In some implementations, R x For -OH. In some implementations, R x It is -NH2.

[0264] In some implementation schemes, R x It is a 3- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0265] In some implementation schemes, R x It is a 3- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S.

[0266] In some implementation schemes, R x It is a 3-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 4-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 5-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0267] In some implementation schemes, R x It is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0268] In some implementation schemes, R x It is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R x It is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S.

[0269] In some implementation schemes, each R x For H, C 1-6 Alkyl group or -OH group.

[0270] In some implementation schemes, R y For H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0271] In some implementation schemes, R y For H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, or -NH2.

[0272] In some implementation schemes, R y For H.

[0273] In some implementation schemes, R y C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6Alkoxy, halogen, -CN, -OH, -NH2, 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S, or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0274] In some implementation schemes, R y C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkoxy, halogen, -CN, -OH, or -NH2.

[0275] In some implementation schemes, R y C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl or C 1-6 Alkyl group.

[0276] In some implementation schemes, R y C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0277] In some implementation schemes, R y C 1-6 Alkyl group. In some embodiments, R y It is methyl. In some embodiments, R y It is ethyl. In some embodiments, R y It is propyl. In some embodiments, R y For butyl. In some implementations, R y It is pentyl. In some implementations, R y For its own foundation. In some implementation schemes, R y It is isopropyl. In some embodiments, R y It is isobutyl. In some embodiments, R y It is isopentyl. In some embodiments, R y It is an allotropic group. In some implementations, R y It is sec-butyl. In some implementations, R y It is sec-amyl. In some implementations, R y For Zhongjiji. In some implementations, R y It is tert-butyl.

[0278] In some implementation schemes, R y C 2-6 Alkenyl. In some embodiments, R y It is C2-olefinic. In some embodiments, R yIt is a C3 alkenyl group. In some embodiments, R y It is a C4 alkenyl group. In some embodiments, R y It is a C5 alkenyl group. In some embodiments, R y It is a C6 alkenyl group.

[0279] In some implementation schemes, R y C 2-6 Alkyne group. In some embodiments, R y It is a C2 acetylene group. In some embodiments, R y It is a C3 acetyl group. In some embodiments, R y It is a C4 acetylene group. In some embodiments, R y It is a C5 acetyl group. In some embodiments, R y It is a C6 acetylene group.

[0280] In some implementation schemes, R y C 1-6 Alkyl group. In some embodiments, R y It is methoxylated. In some embodiments, R y It is ethoxylated. In some embodiments, R y It is propoxylated. In some embodiments, R y It is butoxylated. In some embodiments, R y It is pentoxygenated. In some embodiments, R y It is an hexoxy group.

[0281] In some implementation schemes, R y It can be a halogen, -CN, -OH, or -NH2.

[0282] In some implementation schemes, R y It is a halogen. In some implementations, R y It can be F, Cl, Br, or I. In some implementations, R y It is F, Cl, or Br. In some implementations, R y For F. In some implementations, R y For Cl. In some implementations, R y For Br. In some implementations, R y For I.

[0283] In some implementation schemes, R y For -CN. In some implementations, R y For -OH. In some implementations, R y It is -NH2.

[0284] In some implementation schemes, R yIt is a 3- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0285] In some implementation schemes, R y It is a 3- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O and S.

[0286] In some implementation schemes, R y It is a 3-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 4-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 5-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0287] In some implementation schemes, R y It is a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S.

[0288] In some implementation schemes, R y It is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R y It is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S.

[0289] In some implementation schemes, each R yFor H, C 1-6 Alkyl group or -OH group.

[0290] In some implementations, R1 is H or C. 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0291] In some implementations, R1 is H.

[0292] In some implementations, R1 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0293] In some implementations, R1 is C 1-6 Alkyl group. In some embodiments, R1 is methyl. In some embodiments, R1 is ethyl. In some embodiments, R1 is propyl. In some embodiments, R1 is butyl. In some embodiments, R1 is pentyl. In some embodiments, R1 is hexyl. In some embodiments, R1 is isopropyl. In some embodiments, R1 is isobutyl. In some embodiments, R1 is isopentyl. In some embodiments, R1 is isohexyl. In some embodiments, R1 is sec-butyl. In some embodiments, R1 is sec-pentyl. In some embodiments, R1 is sec-hexyl. In some embodiments, R1 is tert-butyl.

[0294] In some implementations, R1 is C 2-6 Alkenyl. In some embodiments, R1 is C2 alkenyl. In some embodiments, R1 is C3 alkenyl. In some embodiments, R1 is C4 alkenyl. In some embodiments, R1 is C5 alkenyl. In some embodiments, R1 is C6 alkenyl.

[0295] In some implementations, R1 is C 2-6 Alkyne group. In some embodiments, R1 is C2 alkynyl. In some embodiments, R1 is C3 alkynyl. In some embodiments, R1 is C4 alkynyl. In some embodiments, R1 is C5 alkynyl. In some embodiments, R1 is C6 alkynyl.

[0296] In some implementations, each R1 is H or C. 1-6 alkyl.

[0297] In some implementations, each of R2 and R3 is independently H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0298] In some implementations, each of R2 and R3 is independently H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2, where R2 or R3 is not H, wherein -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0299] In some implementations, each of R2 and R3 is independently H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11-C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S).

[0300] In some implementations, each of R2 and R3 is independently H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2, where R2 or R3 is not H.

[0301] In some implementations, each R2 and R3 is independently C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S).

[0302] In some implementations, each R2 and R3 is independently C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0303] In some implementations, each R2 and R3 is independently -OC 1-6 Alkyl, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2, or -C(O)NR 11 -S(O)2R 11 .

[0304] In some implementations, R2 or R3 is not H.

[0305] In some implementations, R2 is not H.

[0306] In some implementations, R3 is not H.

[0307] In some implementations, R2 is H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0308] In some implementations, R2 is H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2, where R2 or R3 is not H, wherein -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0309] In some implementations, R2 is H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S).

[0310] In some implementations, R2 is H, C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11-C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0311] In some implementations, R2 is H.

[0312] In some implementations, R2 is C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S).

[0313] In some implementations, R2 is C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0314] In some implementations, R2 is C 2-6 alkenyl or C 2-6 Alkyne group.

[0315] In some implementations, R2 is C 2-6 Alkenyl. In some embodiments, R2 is C2-alkenyl. In some embodiments, R2 is C3-alkenyl. In some embodiments, R2 is C4-alkenyl. In some embodiments, R2 is C5-alkenyl. In some embodiments, R2 is C6-alkenyl.

[0316] In some implementations, R2 is C 2-6 Alkyne group. In some embodiments, R2 is C2 alkynyl. In some embodiments, R2 is C3 alkynyl. In some embodiments, R2 is C4 alkynyl. In some embodiments, R2 is C5 alkynyl. In some embodiments, R2 is C6 alkynyl.

[0317] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0318] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0319] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl.

[0320] In some implementations, R2 is -OC 1-6Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with 5 to 13 heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0321] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 Alkyne substitution has C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0322] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 Alkyne substitution has C 6-10 Aryl.

[0323] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl substitution has 5 to 13 heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0324] In some implementations, R2 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 Alkyne group.

[0325] In some implementations, R2 is -OC 1-6 Alkyl groups, optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0326] In some implementations, R2 is -OC 1-6 Alkyl groups, optionally substituted with C6-10 Aryl.

[0327] In some implementations, R2 is -OC 1-6 Alkyl groups, optionally substituted with phenyl groups.

[0328] In some embodiments, R2 is -O-methyl, which may optionally be substituted with a phenyl group.

[0329] In some implementations, R2 is -OC 1-6 Alkyl groups, which are substituted with phenyl groups.

[0330] In some embodiments, R2 is -O-methyl, which is substituted with phenyl.

[0331] In some implementations, R2 is -OC 1-6 Alkyl groups, optionally substituted with 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S.

[0332] In some implementations, R2 is -OC 1-6 Alkyl groups, which are substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0333] In some implementations, R2 is -OC 1-6 Alkyl groups, which are substituted with C 6-10 Aryl.

[0334] In some implementations, R2 is -OC 1-6 Alkyl groups, which are substituted with 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S.

[0335] In some implementations, R2 is -OC 1-6 Alkyl group. In some embodiments, R2 is -O-methyl. In some embodiments, R2 is -O-ethyl. In some embodiments, R2 is -O-propyl. In some embodiments, R2 is -O-butyl. In some embodiments, R2 is -O-pentyl. In some embodiments, R2 is -O-hexyl. In some embodiments, R2 is -O-isopropyl. In some embodiments, R2 is -O-isobutyl. In some embodiments, R2 is -O-isopentyl. In some embodiments, R2 is -O-isohexyl. In some embodiments, R2 is -O-sec-butyl. In some embodiments, R2 is -O-sec-pentyl. In some embodiments, R2 is -O-sec-hexyl. In some embodiments, R2 is -O-tert-butyl.

[0336] In some implementations, R2 is -OC 2-6 Alkenyl group, which may be optionally substituted with C6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0337] In some implementations, R2 is -OC 2-6 Alkenyl group, which may be optionally substituted with C 6-10 Aryl.

[0338] In some implementations, R2 is -OC 2-6 Alkenyl groups, optionally substituted with 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S.

[0339] In some implementations, R2 is -OC 2-6 Alkenyl groups, which are substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0340] In some implementations, R2 is -OC 2-6 Alkenyl groups, which are substituted with C 6-10 Aryl.

[0341] In some implementations, R2 is -OC 2-6 Alkenyl groups, which are substituted with 5 to 13 heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O and S.

[0342] In some implementations, R2 is -OC 2-6 Alkenyl. In some embodiments, R2 is -O-C2 alkenyl. In some embodiments, R2 is -O-C3 alkenyl. In some embodiments, R2 is -O-C4 alkenyl. In some embodiments, R2 is -O-C5 alkenyl. In some embodiments, R2 is -O-C6 alkenyl.

[0343] In some implementations, R2 is -OC 2-6 The alkynyl group, which may be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0344] In some implementations, R2 is -OC 2-6 The alkynyl group, which may be optionally substituted with C 6-10 Aryl.

[0345] In some implementations, R2 is -OC 2-6 Alkyne group, optionally substituted with 5 to 13 heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O and S.

[0346] In some implementations, R2 is -OC 2-6 Alkyne group, which has C substitutions 6-10Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0347] In some implementations, R2 is -OC 2-6 Alkyne group, which has C substitutions 6-10 Aryl.

[0348] In some implementations, R2 is -OC 2-6 Alkyne group, which is substituted with 5 to 13 heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O and S.

[0349] In some implementations, R2 is -OC 2-6 Alkyne group. In some embodiments, R2 is -O-C2 alkynyl. In some embodiments, R2 is -O-C3 alkynyl. In some embodiments, R2 is -O-C4 alkynyl. In some embodiments, R2 is -O-C5 alkynyl. In some embodiments, R2 is -O-C6 alkynyl.

[0350] In some implementations, R2 is -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0351] In some implementations, R2 is -C(O)R 11 -C(O)OR 11 、or -C(O)N(R) 11 )2.

[0352] In some implementations, R2 is -C(O)R 11 In some implementations, R2 is -C(O)OR 11 In some implementations, R2 is -C(O)N(R 11 )2.

[0353] In some implementations, R2 is -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0354] In some implementations, R2 is -C(O)NR 11 -S(O)2R 11 In some implementations, R2 is -C(O)NR 11 -S(O)2-OR 11 In some implementations, R2 is -C(O)NR 11 -S(O)2-N(R 11 )2.

[0355] In some implementations, R2 is -OC 1-6 Alkyl, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2, or -C(O)NR 11 -S(O)2R 11 .

[0356] In some embodiments, R2 is -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S).

[0357] In some embodiments, R2 is -O- (a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R2 is -O- (a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R2 is -O- (a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R2 is -O- (an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R2 is -O- (a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R2 is -O- (a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S).

[0358] In some embodiments, R2 is -O-methyl, -O-methyl substituted with phenyl, or -C(O)2CH3.

[0359] In some embodiments, R2 is -O-methyl or -O-methyl substituted with phenyl.

[0360] In some implementations, R3 is H or C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R)11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 2. or -O- (containing 1-4 heteroatoms selected from N, O and S, consisting of 5- to 10-membered heteroaryl groups), wherein R2 or R3 is not H, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0361] In some implementations, R3 is H or C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2, where R2 or R3 is not H, wherein -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0362] In some implementations, R3 is H or C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11-C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S).

[0363] In some implementations, R3 is H or C. 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0364] In some implementations, R3 is H.

[0365] In some implementations, R3 is C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 -C(O)NR 11 -S(O)2-N(R 11 )2, or -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S).

[0366] In some implementations, R3 is C 2-6 alkenyl, C 2-6 alkynyl group, -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0367] In some implementations, R3 is C 2-6 alkenyl or C 2-6 Alkyne group.

[0368] In some implementations, R3 is C 2-6 Alkenyl group. In some embodiments, R3 is C2 alkenyl. In some embodiments, R3 is C3 alkenyl. In some embodiments, R3 is C4 alkenyl. In some embodiments, R3 is C5 alkenyl. In some embodiments, R3 is C6 alkenyl.

[0369] In some implementations, R3 is C 2-6 Alkynyl group. In some embodiments, R3 is C2 alkynyl. In some embodiments, R3 is C3 alkynyl. In some embodiments, R3 is C4 alkynyl. In some embodiments, R3 is C5 alkynyl. In some embodiments, R3 is C6 alkynyl.

[0370] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, -OC 2-6 alkynyl group, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0371] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6The alkynyl group can be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0372] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with C 6-10 Aryl.

[0373] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 The alkynyl group can be optionally substituted with 5 to 13 heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0374] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 Alkyne substitution has C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0375] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 Alkyne substitution has C 6-10 Aryl.

[0376] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 alkynyl group, wherein the -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6The alkynyl substitution has 5 to 13 heteroaryl groups containing 1 to 4 heteroatoms selected from N, O and S.

[0377] In some implementations, R3 is -OC 1-6 Alkyl, -OC 2-6 alkenyl, or -OC 2-6 Alkyne group.

[0378] In some implementations, R3 is -OC 1-6 Alkyl groups, optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0379] In some implementations, R3 is -OC 1-6 Alkyl groups, optionally substituted with C 6-10 Aryl.

[0380] In some implementations, R3 is -OC 1-6 Alkyl groups, optionally substituted with phenyl groups.

[0381] In some embodiments, R3 is -O-methyl, which may optionally be substituted with a phenyl group.

[0382] In some implementations, R3 is -OC 1-6 Alkyl groups, which are substituted with phenyl groups.

[0383] In some embodiments, R3 is -O-methyl, which is substituted with phenyl.

[0384] In some implementations, R3 is -OC 1-6 Alkyl groups, optionally substituted with 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S.

[0385] In some implementations, R3 is -OC 1-6 Alkyl groups, which are substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0386] In some implementations, R3 is -OC 1-6 Alkyl groups, which are substituted with C 6-10 Aryl.

[0387] In some implementations, R3 is -OC 1-6 Alkyl groups, which are substituted with 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S.

[0388] In some implementations, R3 is -OC 1-6Alkyl group. In some embodiments, R3 is -O-methyl. In some embodiments, R3 is -O-ethyl. In some embodiments, R3 is -O-propyl. In some embodiments, R3 is -O-butyl. In some embodiments, R3 is -O-pentyl. In some embodiments, R3 is -O-hexyl. In some embodiments, R3 is -O-isopropyl. In some embodiments, R3 is -O-isobutyl. In some embodiments, R3 is -O-isopentyl. In some embodiments, R3 is -O-isohexyl. In some embodiments, R3 is -O-sec-butyl. In some embodiments, R3 is -O-sec-pentyl. In some embodiments, R3 is -O-sec-hexyl. In some embodiments, R3 is -O-tert-butyl.

[0389] In some implementations, R3 is -OC 2-6 Alkenyl group, which may be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0390] In some implementations, R3 is -OC 2-6 Alkenyl group, which may be optionally substituted with C 6-10 Aryl.

[0391] In some implementations, R3 is -OC 2-6 Alkenyl groups, optionally substituted with 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S.

[0392] In some implementations, R3 is -OC 2-6 Alkenyl groups, which are substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0393] In some implementations, R3 is -OC 2-6 Alkenyl groups, which are substituted with C 6-10 Aryl.

[0394] In some implementations, R3 is -OC 2-6 Alkenyl groups, which are substituted with 5 to 13 heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O and S.

[0395] In some implementations, R3 is -OC 2-6 Alkenyl. In some embodiments, R3 is -O-C2 alkenyl. In some embodiments, R3 is -O-C3 alkenyl. In some embodiments, R3 is -O-C4 alkenyl. In some embodiments, R3 is -O-C5 alkenyl. In some embodiments, R3 is -O-C6 alkenyl.

[0396] In some implementations, R3 is -OC 2-6 The alkynyl group, which may be optionally substituted with C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0397] In some implementations, R3 is -OC 2-6 The alkynyl group, which may be optionally substituted with C 6-10 Aryl.

[0398] In some implementations, R3 is -OC 2-6 Alkyne group, optionally substituted with 5 to 13 heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O and S.

[0399] In some implementations, R3 is -OC 2-6 Alkyne group, which has C substitutions 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0400] In some implementations, R3 is -OC 2-6 Alkyne group, which has C substitutions 6-10 Aryl.

[0401] In some implementations, R3 is -OC 2-6 Alkyne group, which is substituted with 5 to 13 heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O and S.

[0402] In some implementations, R3 is -OC 2-6 Alkynyl group. In some embodiments, R3 is -O-C2 alkynyl. In some embodiments, R3 is -O-C3 alkynyl. In some embodiments, R3 is -O-C4 alkynyl. In some embodiments, R3 is -O-C5 alkynyl. In some embodiments, R3 is -O-C6 alkynyl.

[0403] In some implementations, R3 is -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2、-C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0404] In some implementations, R3 is -C(O)R 11 -C(O)OR 11、or -C(O)N(R) 11 )2.

[0405] In some implementations, R3 is -C(O)R 11 In some implementations, R3 is -C(O)OR 11 In some implementations, R3 is -C(O)N(R 11 )2.

[0406] In some implementations, R3 is -C(O)NR 11 -S(O)2R 11 -C(O)NR 11 -S(O)2-OR 11 、or -C(O)NR 11 -S(O)2-N(R 11 )2.

[0407] In some implementations, R3 is -C(O)NR 11 -S(O)2R 11 In some implementations, R3 is -C(O)NR. 11 -S(O)2-OR 11 In some implementations, R3 is -C(O)NR. 11 -S(O)2-N(R 11 )2.

[0408] In some implementations, R3 is -OC 1-6 Alkyl, -C(O)R 11 -C(O)OR 11 -C(O)N(R) 11 )2, or -C(O)NR 11 -S(O)2R 11 .

[0409] In some embodiments, R3 is -O- (a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O and S).

[0410] In some embodiments, R3 is -O- (a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R3 is -O- (a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R3 is -O- (a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R3 is -O- (an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R3 is -O- (a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R3 is -O- (a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S).

[0411] In some embodiments, R3 is -O-methyl, -O-methyl substituted with phenyl, or -C(O)2CH3.

[0412] In some embodiments, R3 is -O-methyl or -O-methyl substituted with phenyl.

[0413] In some implementations, each R5 and R6 is independently H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0414] R5 and R6, together with the atoms they are attached to, form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0415] In some implementations, each R5 and R6 is independently C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, or -C(O)R7, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s, or

[0416] R5 and R6, together with the atoms they are attached to, form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0417] In some implementations, each R5 and R6 is independently H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0418] In some implementations, each R5 and R6 is independently H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0419] In some implementations, each R5 and R6 is independently H.

[0420] In some implementations, each R5 and R6 is independently C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0421] In some implementations, each R5 and R6 is independently C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0422] In some implementations, each R5 and R6 is independently H, C 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, or -C(O)R7, wherein the alkyl, cycloalkyl, heterocyclic, aryl or heteroaryl may optionally be substituted with one or more R7s.

[0423] In some implementations, each R5 and R6 is independently H, C 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0424] In some implementations, each R5 and R6 is independently H, C 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is substituted with one or more R7 atoms.

[0425] In some embodiments, R5 and R6 together with the atoms to which they are attached form a 4- to 10-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is substituted with one or more R7.

[0426] In some implementations, R5 is H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0427] In some implementations, R5 is H, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0428] In some implementations, R5 is H.

[0429] In some implementations, R5 is C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0430] In some implementations, R5 is C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0431] In some implementations, R5 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 The alkynyl group, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more R7 groups.

[0432] In some implementations, R5 is C 1-6The alkyl group is optionally substituted with one or more R7 groups. In some embodiments, R5 is methyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is ethyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is propyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is butyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is pentyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is hexyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is isopropyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is isobutyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is isopentyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is isohexyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is sec-butyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is sec-pentyl, optionally substituted with one or more R7 groups. In some embodiments, R5 is sec-hexyl, optionally substituted with one or more R7. In some embodiments, R5 is tert-butyl, optionally substituted with one or more R7.

[0433] In some implementations, R5 is C 2-6 The alkenyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C2 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C3 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C4 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C5 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C6 alkenyl group, optionally substituted with one or more R7s.

[0434] In some implementations, R5 is C 2-6 The alkynyl group is optionally substituted with one or more R7 groups. In some embodiments, R5 is a C2 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C3 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C4 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C5 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C6 alkynyl group, optionally substituted with one or more R7 groups.

[0435] In some implementations, R5 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is substituted with one or more R7 groups.

[0436] In some implementations, R5 is C 1-6 The alkyl group is substituted with one or more R7 molecules. In some embodiments, R5 is methyl, substituted with one or more R7 molecules. In some embodiments, R5 is ethyl, substituted with one or more R7 molecules. In some embodiments, R5 is propyl, substituted with one or more R7 molecules. In some embodiments, R5 is butyl, substituted with one or more R7 molecules. In some embodiments, R5 is pentyl, substituted with one or more R7 molecules. In some embodiments, R5 is hexyl, substituted with one or more R7 molecules. In some embodiments, R5 is isopropyl, substituted with one or more R7 molecules. In some embodiments, R5 is isobutyl, substituted with one or more R7 molecules. In some embodiments, R5 is isopentyl, substituted with one or more R7 molecules. In some embodiments, R5 is isohexyl, substituted with one or more R7 molecules. In some embodiments, R5 is sec-butyl, substituted with one or more R7 molecules. In some embodiments, R5 is sec-pentyl, substituted with one or more R7 molecules. In some embodiments, R5 is sec-hexyl, substituted with one or more R7 molecules. In some implementations, R5 is tert-butyl, which is substituted with one or more R7s.

[0437] In some implementations, R5 is C 2-6 The R5 group is an alkenyl group substituted with one or more R7 groups. In some embodiments, R5 is a C2 alkenyl group substituted with one or more R7 groups. In some embodiments, R5 is a C3 alkenyl group substituted with one or more R7 groups. In some embodiments, R5 is a C4 alkenyl group substituted with one or more R7 groups. In some embodiments, R5 is a C5 alkenyl group substituted with one or more R7 groups. In some embodiments, R5 is a C6 alkenyl group substituted with one or more R7 groups.

[0438] In some implementations, R5 is C 2-6 The alkynyl group is substituted with one or more R7 groups. In some embodiments, R5 is a C2 alkynyl group substituted with one or more R7 groups. In some embodiments, R5 is a C3 alkynyl group substituted with one or more R7 groups. In some embodiments, R5 is a C4 alkynyl group substituted with one or more R7 groups. In some embodiments, R5 is a C5 alkynyl group substituted with one or more R7 groups. In some embodiments, R5 is a C6 alkynyl group substituted with one or more R7 groups.

[0439] In some implementations, R5 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is substituted with an R7.

[0440] In some implementations, R5 is C 1-6 The alkyl group is substituted with one R7. In some embodiments, R5 is methyl, substituted with one R7. In some embodiments, R5 is ethyl, substituted with one R7. In some embodiments, R5 is propyl, substituted with one R7. In some embodiments, R5 is butyl, substituted with one R7. In some embodiments, R5 is pentyl, substituted with one R7. In some embodiments, R5 is hexyl, substituted with one R7. In some embodiments, R5 is isopropyl, substituted with one R7. In some embodiments, R5 is isobutyl, substituted with one R7. In some embodiments, R5 is isopentyl, substituted with one R7. In some embodiments, R5 is isohexyl, substituted with one R7. In some embodiments, R5 is sec-butyl, substituted with one R7. In some embodiments, R5 is sec-pentyl, substituted with one R7. In some embodiments, R5 is sec-hexyl, substituted with one R7. In some embodiments, R5 is tert-butyl, substituted with one R7.

[0441] In some implementations, R5 is C 2-6 The alkenyl group is substituted with one R7. In some embodiments, R5 is a C2 alkenyl group substituted with one R7. In some embodiments, R5 is a C3 alkenyl group substituted with one R7. In some embodiments, R5 is a C4 alkenyl group substituted with one R7. In some embodiments, R5 is a C5 alkenyl group substituted with one R7. In some embodiments, R5 is a C6 alkenyl group substituted with one R7.

[0442] In some implementations, R5 is C 2-6 The alkynyl group has an R7 substituted group. In some embodiments, R5 is a C2 alkynyl group with an R7 substituted group. In some embodiments, R5 is a C3 alkynyl group with an R7 substituted group. In some embodiments, R5 is a C4 alkynyl group with an R7 substituted group. In some embodiments, R5 is a C5 alkynyl group with an R7 substituted group. In some embodiments, R5 is a C6 alkynyl group with an R7 substituted group.

[0443] In some implementations, R5 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0444] In some implementations, R5 is C 1-6Alkyl group. In some embodiments, R5 is methyl. In some embodiments, R5 is ethyl. In some embodiments, R5 is propyl. In some embodiments, R5 is butyl. In some embodiments, R5 is pentyl. In some embodiments, R5 is hexyl. In some embodiments, R5 is isopropyl. In some embodiments, R5 is isobutyl. In some embodiments, R5 is isopentyl. In some embodiments, R5 is isohexyl. In some embodiments, R5 is sec-butyl. In some embodiments, R5 is sec-pentyl. In some embodiments, R5 is sec-hexyl. In some embodiments, R5 is tert-butyl.

[0445] In some implementations, R5 is C 2-6 Alkenyl. In some embodiments, R5 is C2 alkenyl. In some embodiments, R5 is C3 alkenyl. In some embodiments, R5 is C4 alkenyl. In some embodiments, R5 is C5 alkenyl. In some embodiments, R5 is C6 alkenyl.

[0446] In some implementations, R5 is C 2-6 Alkynyl group. In some embodiments, R5 is C2 alkynyl. In some embodiments, R5 is C3 alkynyl. In some embodiments, R5 is C4 alkynyl. In some embodiments, R5 is C5 alkynyl. In some embodiments, R5 is C6 alkynyl.

[0447] In some implementations, R5 is C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0448] In some implementations, R5 is C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0449] In some implementations, R5 is C 3-10 Cycloalkyl or a 3- to 13-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with one or more R7s.

[0450] In some implementations, R5 is C 3-10 Cycloalkyl or 3- to 13-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S.

[0451] In some implementations, R5 is C 3-10 Cycloalkyl, which may optionally be substituted with one or more R7s.

[0452] In some embodiments, R5 is a C3 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C4 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C5 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C6 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C7 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C8 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C9 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is a C... 10 Cycloalkyl, which may optionally be substituted with one or more R7s.

[0453] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group, optionally substituted with one or more R7 groups. In some embodiments, R5 is a C9-C9 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is C9-C. 10 A bicyclic saturated cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R5 is C9-C. 10 The bicyclic partially saturated cycloalkyl group is optionally substituted with one or more R7s. In some embodiments, R5 is C8-C6. 10 Polycyclic cycloalkyl groups, optionally substituted with one or more R7s.

[0454] In some implementations, R5 is C 3-10 Cycloalkyl, which is substituted with one or more R7s.

[0455] In some embodiments, R5 is a C3 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C4 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C5 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C6 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C7 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C8 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C9 cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C... 10 Cycloalkyl, which is substituted with one or more R7s.

[0456] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R7s. In some embodiments, R5 is a C9-C9 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl group, wherein one or more R7s are substituted. In some embodiments, R5 is C9-C. 10 A bicyclic saturated cycloalkyl group, substituted with one or more R7s. In some embodiments, R5 is C9-C. 10 The bicyclic partially saturated cycloalkyl group is substituted with one or more R7s. In some embodiments, R5 is C8-C6. 10 Polycyclic cycloalkyl groups, which are substituted with one or more R7s.

[0457] In some implementations, R5 is C 3-10 Cycloalkyl, which has one R7 substitution.

[0458] In some embodiments, R5 is a C3 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C4 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C5 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C6 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C7 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C8 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C9 cycloalkyl group substituted with one R7. In some embodiments, R5 is a C... 10 Cycloalkyl, which has one R7 substitution.

[0459] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group, substituted with one R7. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group, substituted with one R7. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group, substituted with one R7. In some embodiments, R5 is a C9-C9 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl group, wherein one of the substitutions is R7. In some embodiments, R5 is C9-C. 10 A bicyclic saturated cycloalkyl group, wherein one of the substitutions is R7. In some embodiments, R5 is C9-C. 10 The bicyclic partially saturated cycloalkyl group has one R7 substituted. In some embodiments, R5 is C8-C6. 10 Polycyclic cycloalkyl groups, which have one R7 substitution.

[0460] In some implementations, R5 is C 3-10 Cycloalkyl.

[0461] In some embodiments, R5 is a C3 cycloalkyl group. In some embodiments, R5 is a C4 cycloalkyl group. In some embodiments, R5 is a C5 cycloalkyl group. In some embodiments, R5 is a C6 cycloalkyl group. In some embodiments, R5 is a C7 cycloalkyl group. In some embodiments, R5 is a C8 cycloalkyl group. In some embodiments, R5 is a C9 cycloalkyl group. In some embodiments, R5 is a C... 10 Cycloalkyl.

[0462] In some embodiments, R5 is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R5 is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R5 is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R5 is a C9-C5 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl. In some embodiments, R5 is C9-C. 10 Bicyclic saturated cycloalkyl group. In some embodiments, R5 is C9-C6. 10 Bicyclic partially saturated cycloalkyl group. In some embodiments, R5 is C8-C6. 10 Polycyclic cycloalkyl groups.

[0463] In some embodiments, R5 is a 3- to 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0464] In some embodiments, R5 is a 3- to 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0465] In some embodiments, R5 is a 3- to 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0466] In some embodiments, R5 is a 3- to 13-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 3-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 4-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 5-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S.

[0467] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 7-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 8-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 9-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 10-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 11-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 12-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0468] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 7-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 8-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7. In some embodiments, R5 is a 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7.

[0469] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0470] In some embodiments, R5 is a 7- to 13-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0471] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 9-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 10-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 11-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 12-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0472] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0473] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0474] In some embodiments, R5 is a 9- to 13-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S.

[0475] In some implementations, R5 is C 6-10 Aryl or 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl group is optionally substituted with one or more R7 atoms.

[0476] In some implementations, R5 is C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0477] In some implementations, R5 is C 6-10 Aryl group, which may optionally have one or more R7s.

[0478] In some implementations, R5 is C 6-8 The aryl group is optionally substituted with one or more R7 groups. In some embodiments, R5 is a phenyl group optionally substituted with one or more R7 groups.

[0479] In some implementations, R5 is C 6-8The aryl group is substituted with one or more R7 groups. In some embodiments, R5 is a phenyl group substituted with one or more R7 groups.

[0480] In some implementations, R5 is C 6-8 The aryl group is substituted with one R7. In some embodiments, R5 is a phenyl group substituted with one R7.

[0481] In some implementations, R5 is C 6-10 Aryl.

[0482] In some implementations, R5 is C 6-8 Aryl. In some embodiments, R5 is phenyl.

[0483] In some embodiments, R5 is a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 11-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 12-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0484] In some embodiments, R5 is a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R5 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0485] In some embodiments, R5 is a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0486] In some embodiments, R5 is a 5- to 13-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0487] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 9-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 10-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 11-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 12-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0488] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0489] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0490] In some embodiments, R5 is a 9- to 13-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0491] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 9-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 10-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is an 11-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 12-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R5 is a 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0492] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 9-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 10-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is an 11-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 12-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 is a 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0493] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 9-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 10-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is an 11-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 12-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 is a 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0494] In some embodiments, R5 is a 9- to 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 9-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 10-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is an 11-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 12-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 is a 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0495] In some implementations, R5 is H, C 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, or -C(O)R7, wherein the alkyl, cycloalkyl, heterocyclic, aryl or heteroaryl may optionally be substituted with one or more R7s.

[0496] In some implementations, R5 is H, C 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0497] In some implementations, R5 is H, C 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is substituted with one or more R7 atoms.

[0498] In some embodiments, R5 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0499] In some implementations, R5 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0500] In some embodiments, R5 is phenyl, pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0501] In some embodiments, R5 is pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0502] In some implementations, R5 is pyridine, pyrimidine, or indazole.

[0503] In some implementations, R5 is indazole.

[0504] In some embodiments, R5 is tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0505] In some implementations, R5 is a tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0506] In some embodiments, R5 is 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, benzo[d]oxazol-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0507] In some embodiments, R5 is 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, or benzo[d]oxazol-2(3H)-one, benzo[d]isoxazole.

[0508] In some implementations, R5 is 9H-carbazole.

[0509] In some implementations, R6 is H or C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0510] In some implementations, R6 is H or C. 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0511] In some implementations, R6 is H.

[0512] In some implementations, R6 is C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0513] In some implementations, R6 is C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0514] In some implementations, R6 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 The alkynyl group, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more R7 groups.

[0515] In some implementations, R6 is C 1-6 The alkyl group is optionally substituted with one or more R7s. In some embodiments, R6 is methyl, optionally substituted with one or more R7s. In some embodiments, R6 is ethyl, optionally substituted with one or more R7s. In some embodiments, R6 is propyl, optionally substituted with one or more R7s. In some embodiments, R6 is butyl, optionally substituted with one or more R7s. In some embodiments, R6 is pentyl, optionally substituted with one or more R7s. In some embodiments, R6 is hexyl, optionally substituted with one or more R7s. In some embodiments, R6 is isopropyl, optionally substituted with one or more R7s. In some embodiments, R6 is isobutyl, optionally substituted with one or more R7s. In some embodiments, R6 is isopentyl, optionally substituted with one or more R7s. In some embodiments, R6 is isohexyl, optionally substituted with one or more R7s. In some embodiments, R6 is sec-butyl, optionally substituted with one or more R7s. In some embodiments, R6 is sec-pentyl, optionally substituted with one or more R7s. In some embodiments, R6 is sec-hexyl, optionally substituted with one or more R7s. In some embodiments, R6 is tert-butyl, optionally substituted with one or more R7s.

[0516] In some implementations, R6 is C 2-6The alkenyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C2 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C3 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C4 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C5 alkenyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C6 alkenyl group, optionally substituted with one or more R7s.

[0517] In some implementations, R6 is C 2-6 The alkynyl group is optionally substituted with one or more R7 groups. In some embodiments, R6 is a C2 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R6 is a C3 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R6 is a C4 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R6 is a C5 alkynyl group, optionally substituted with one or more R7 groups. In some embodiments, R6 is a C6 alkynyl group, optionally substituted with one or more R7 groups.

[0518] In some implementations, R6 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is substituted with one or more R7 groups.

[0519] In some implementations, R6 is C 1-6 The alkyl group is substituted with one or more R7 molecules. In some embodiments, R6 is methyl, substituted with one or more R7 molecules. In some embodiments, R6 is ethyl, substituted with one or more R7 molecules. In some embodiments, R6 is propyl, substituted with one or more R7 molecules. In some embodiments, R6 is butyl, substituted with one or more R7 molecules. In some embodiments, R6 is pentyl, substituted with one or more R7 molecules. In some embodiments, R6 is hexyl, substituted with one or more R7 molecules. In some embodiments, R6 is isopropyl, substituted with one or more R7 molecules. In some embodiments, R6 is isobutyl, substituted with one or more R7 molecules. In some embodiments, R6 is isopentyl, substituted with one or more R7 molecules. In some embodiments, R6 is isohexyl, substituted with one or more R7 molecules. In some embodiments, R6 is sec-butyl, substituted with one or more R7 molecules. In some embodiments, R6 is sec-pentyl, substituted with one or more R7 molecules. In some embodiments, R6 is sec-hexyl, substituted with one or more R7 molecules. In some implementations, R6 is tert-butyl, which is substituted with one or more R7s.

[0520] In some implementations, R6 is C 2-6 The R6 is an alkenyl group, substituted with one or more R7s. In some embodiments, R6 is a C2 alkenyl group, substituted with one or more R7s. In some embodiments, R6 is a C3 alkenyl group, substituted with one or more R7s. In some embodiments, R6 is a C4 alkenyl group, substituted with one or more R7s. In some embodiments, R6 is a C5 alkenyl group, substituted with one or more R7s. In some embodiments, R6 is a C6 alkenyl group, substituted with one or more R7s.

[0521] In some implementations, R6 is C 2-6 The R6 group is an alkynyl group, substituted with one or more R7 groups. In some embodiments, the R6 group is a C2 alkynyl group, substituted with one or more R7 groups. In some embodiments, the R6 group is a C3 alkynyl group, substituted with one or more R7 groups. In some embodiments, the R6 group is a C4 alkynyl group, substituted with one or more R7 groups. In some embodiments, the R6 group is a C5 alkynyl group, substituted with one or more R7 groups. In some embodiments, the R6 group is a C6 alkynyl group, substituted with one or more R7 groups.

[0522] In some implementations, R6 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is substituted with an R7.

[0523] In some implementations, R6 is C 1-6 The alkyl group is substituted with one R7. In some embodiments, R6 is methyl, substituted with one R7. In some embodiments, R6 is ethyl, substituted with one R7. In some embodiments, R6 is propyl, substituted with one R7. In some embodiments, R6 is butyl, substituted with one R7. In some embodiments, R6 is pentyl, substituted with one R7. In some embodiments, R6 is hexyl, substituted with one R7. In some embodiments, R6 is isopropyl, substituted with one R7. In some embodiments, R6 is isobutyl, substituted with one R7. In some embodiments, R6 is isopentyl, substituted with one R7. In some embodiments, R6 is isohexyl, substituted with one R7. In some embodiments, R6 is sec-butyl, substituted with one R7. In some embodiments, R6 is sec-pentyl, substituted with one R7. In some embodiments, R6 is sec-hexyl, substituted with one R7. In some embodiments, R6 is tert-butyl, substituted with one R7.

[0524] In some implementations, R6 is C 2-6The alkenyl group is substituted with one R7. In some embodiments, R6 is a C2 alkenyl group substituted with one R7. In some embodiments, R6 is a C3 alkenyl group substituted with one R7. In some embodiments, R6 is a C4 alkenyl group substituted with one R7. In some embodiments, R6 is a C5 alkenyl group substituted with one R7. In some embodiments, R6 is a C6 alkenyl group substituted with one R7.

[0525] In some implementations, R6 is C 2-6 The alkynyl group has an R7 substituted group. In some embodiments, R6 is a C2 alkynyl group with an R7 substituted group. In some embodiments, R6 is a C3 alkynyl group with an R7 substituted group. In some embodiments, R6 is a C4 alkynyl group with an R7 substituted group. In some embodiments, R6 is a C5 alkynyl group with an R7 substituted group. In some embodiments, R6 is a C6 alkynyl group with an R7 substituted group.

[0526] In some implementations, R6 is C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0527] In some implementations, R6 is C 1-6 Alkyl group. In some embodiments, R6 is methyl. In some embodiments, R6 is ethyl. In some embodiments, R6 is propyl. In some embodiments, R6 is butyl. In some embodiments, R6 is pentyl. In some embodiments, R6 is hexyl. In some embodiments, R6 is isopropyl. In some embodiments, R6 is isobutyl. In some embodiments, R6 is isopentyl. In some embodiments, R6 is isohexyl. In some embodiments, R6 is sec-butyl. In some embodiments, R6 is sec-pentyl. In some embodiments, R6 is sec-hexyl. In some embodiments, R6 is tert-butyl.

[0528] In some implementations, R6 is C 2-6 Alkenyl. In some embodiments, R6 is C2 alkenyl. In some embodiments, R6 is C3 alkenyl. In some embodiments, R6 is C4 alkenyl. In some embodiments, R6 is C5 alkenyl. In some embodiments, R6 is C6 alkenyl.

[0529] In some implementations, R6 is C 2-6 Alkynyl group. In some embodiments, R6 is C2 alkynyl. In some embodiments, R6 is C3 alkynyl. In some embodiments, R6 is C4 alkynyl. In some embodiments, R6 is C5 alkynyl. In some embodiments, R6 is C6 alkynyl.

[0530] In some implementations, R6 is C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0531] In some implementations, R6 is C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0532] In some implementations, R6 is C 3-10 Cycloalkyl or a 3- to 13-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with one or more R7s.

[0533] In some implementations, R6 is C 3-10 Cycloalkyl or 3- to 13-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S.

[0534] In some implementations, R6 is C 3-10 Cycloalkyl, which may optionally be substituted with one or more R7s.

[0535] In some embodiments, R6 is a C3 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C4 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C5 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C6 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C7 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C8 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C9 cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C... 10 Cycloalkyl, which may optionally be substituted with one or more R7s.

[0536] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is a C9-C6 monocyclic cycloalkyl group. 10Bicyclic cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is C9-C. 10 A bicyclic saturated cycloalkyl group, optionally substituted with one or more R7s. In some embodiments, R6 is C9-C. 10 The bicyclic partially saturated cycloalkyl group is optionally substituted with one or more R7s. In some embodiments, R6 is C8-C6. 10 Polycyclic cycloalkyl groups, optionally substituted with one or more R7s.

[0537] In some implementations, R6 is C 3-10 Cycloalkyl, which is substituted with one or more R7s.

[0538] In some embodiments, R6 is a C3 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C4 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C5 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C6 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C7 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C8 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C9 cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C... 10 Cycloalkyl, which is substituted with one or more R7s.

[0539] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R7s. In some embodiments, R6 is a C9-C6 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl group, wherein one or more R7s are substituted. In some embodiments, R6 is C9-C. 10 A bicyclic saturated cycloalkyl group, substituted with one or more R7s. In some embodiments, R6 is C9-C6. 10 The bicyclic partially saturated cycloalkyl group is substituted with one or more R7s. In some embodiments, R6 is C8-C6. 10 Polycyclic cycloalkyl groups, which are substituted with one or more R7s.

[0540] In some implementations, R6 is C 3-10 Cycloalkyl, which has one R7 substitution.

[0541] In some embodiments, R6 is a C3 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C4 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C5 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C6 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C7 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C8 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C9 cycloalkyl group substituted with one R7. In some embodiments, R6 is a C... 10 Cycloalkyl, which has one R7 substitution.

[0542] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group, substituted with one R7. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group, substituted with one R7. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group, substituted with one R7. In some embodiments, R6 is a C9-C6 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl group, wherein one of the substitutions is R7. In some embodiments, R6 is C9-C. 10 A bicyclic saturated cycloalkyl group, wherein one of the substitutions is R7. In some embodiments, R6 is C9-C. 10 The bicyclic partially saturated cycloalkyl group has one R7 substituted. In some embodiments, R6 is C8-C6. 10 Polycyclic cycloalkyl groups, which have one R7 substitution.

[0543] In some implementations, R6 is C 3-10 Cycloalkyl.

[0544] In some embodiments, R6 is a C3 cycloalkyl group. In some embodiments, R6 is a C4 cycloalkyl group. In some embodiments, R6 is a C5 cycloalkyl group. In some embodiments, R6 is a C6 cycloalkyl group. In some embodiments, R6 is a C7 cycloalkyl group. In some embodiments, R6 is a C8 cycloalkyl group. In some embodiments, R6 is a C9 cycloalkyl group. In some embodiments, R6 is a C... 10 Cycloalkyl.

[0545] In some embodiments, R6 is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R6 is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R6 is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R6 is a C9-C6 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl. In some embodiments, R6 is C9-C. 10 Bicyclic saturated cycloalkyl group. In some embodiments, R6 is C9-C6. 10Bicyclic partially saturated cycloalkyl group. In some embodiments, R6 is C8-C6. 10 Polycyclic cycloalkyl groups.

[0546] In some embodiments, R6 is a 3- to 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0547] In some embodiments, R6 is a 3- to 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0548] In some embodiments, R6 is a 3- to 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0549] In some embodiments, R6 is a 3- to 13-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 3-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 4-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 5-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S.

[0550] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 7-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 8-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 12-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0551] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 7-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 8-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 12-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0552] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered bicyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0553] In some embodiments, R6 is a 7- to 13-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered bicyclic heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0554] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 9-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 10-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 11-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 12-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0555] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 12-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0556] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered polycyclic heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0557] In some embodiments, R6 is a 9- to 13-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered polycyclic heterocyclic group containing 1-4 heteroatoms selected from N, O, and S.

[0558] In some implementations, R6 is C 6-10 Aryl or 5- to 13-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl group is optionally substituted with one or more R7 atoms.

[0559] In some implementations, R6 is C 6-10 Aryl or 5- to 13-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0560] In some implementations, R6 is C 6-10 Aryl group, which may optionally have one or more R7s.

[0561] In some implementations, R6 is C 6-8 The aryl group is optionally substituted with one or more R7 groups. In some embodiments, R6 is a phenyl group, optionally substituted with one or more R7 groups.

[0562] In some implementations, R6 is C 6-8The aryl group is substituted with one or more R7 groups. In some embodiments, R6 is a phenyl group substituted with one or more R7 groups.

[0563] In some implementations, R6 is C 6-8 The aryl group is substituted with one R7. In some embodiments, R6 is a phenyl group substituted with one R7.

[0564] In some implementations, R6 is C 6-10 Aryl.

[0565] In some implementations, R6 is C 6-8 Aryl. In some embodiments, R6 is phenyl.

[0566] In some embodiments, R6 is a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 11-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 12-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0567] In some embodiments, R6 is a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 12-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0568] In some embodiments, R6 is a 5- to 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0569] In some embodiments, R6 is a 5- to 13-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0570] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 12-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0571] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 12-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 13-membered bicyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0572] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0573] In some embodiments, R6 is a 9- to 13-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered bicyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0574] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 9-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 10-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is an 11-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 12-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s. In some embodiments, R6 is a 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7s.

[0575] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 9-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 10-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is an 11-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 12-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s. In some embodiments, R6 is a 13-membered polycyclic heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7s.

[0576] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 9-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 10-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is an 11-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 12-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R6 is a 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0577] In some embodiments, R6 is a 9- to 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 9-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 10-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is an 11-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 12-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R6 is a 13-membered polycyclic heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0578] In some implementations, R6 is H or C. 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, 5- to 13-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O and S, or -C(O)R7, wherein the alkyl, cycloalkyl, heterocyclic, aryl or heteroaryl may optionally be substituted with one or more R7s.

[0579] In some implementations, R6 is H or C. 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R7s.

[0580] In some implementations, R6 is H or C. 1-6 Alkyl, C 3-10 Cycloalkyl groups, 3- to 13-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 13-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is substituted with one or more R7 atoms.

[0581] In some embodiments, R6 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0582] In some implementations, R6 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0583] In some embodiments, R6 is phenyl, pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0584] In some embodiments, R6 is pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0585] In some implementations, R6 is pyridine, pyrimidine, or indazole.

[0586] In some implementations, R6 is indazole.

[0587] In some embodiments, R6 is a tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0588] In some implementations, R6 is a tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0589] In some embodiments, R6 is 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, benzo[d]oxazol-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0590] In some embodiments, R6 is 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, or benzo[d]oxazol-2(3H)-one, benzo[d]isoxazole.

[0591] In some implementations, R6 is 9H-carbazole.

[0592] In some embodiments, R5 and R6 together with the atoms to which they are attached form a 4- to 10-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the heterocyclic group or heteroaryl group is optionally substituted with one or more R7.

[0593] In some embodiments, R5 and R6, together with the atoms to which they are attached, form a 4- to 10-membered heterocyclic group containing 1 to 4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0594] In some embodiments, R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7.

[0595] In some embodiments, R5 and R6 together with the atoms they are attached to form a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0596] In some embodiments, R5 and R6 together with the atoms they are attached to form a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7.

[0597] In some embodiments, R5 and R6 together with the atoms they are attached to form a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0598] In some embodiments, R5 and R6 together with the atoms they are attached to form a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0599] In some embodiments, R5 and R6 together with the atoms they are attached to form an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0600] In some embodiments, R5 and R6 together with the atoms they are attached to form a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0601] In some embodiments, R5 and R6 together with the atoms they are attached to form a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0602] In some embodiments, R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O and S, which is substituted with one or more R7.

[0603] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms.

[0604] In some embodiments, R5 and R6 together with the atoms they are attached to form a 4- to 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O and S, with one R7 substituted.

[0605] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, replacing one R7.

[0606] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 4- to 10-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O, and S.

[0607] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S. In some implementations, R5 and R6, together with the atoms they are attached to, form a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S.

[0608] In some embodiments, R5 and R6 together with the atoms they are attached to form a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0609] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R7 atoms. In some embodiments, R5 and R6 together with the atoms they are attached to form a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R7s.

[0610] In some embodiments, R5 and R6 together with the atoms they are attached to form a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O and S, substituted with one or more R7.

[0611] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R7 atoms. In some embodiments, R5 and R6 together with the atoms they are attached to form a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O and S, substituted with one or more R7.

[0612] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R7 substituted. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R7 substituted. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R7 substituted. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R7 substituted. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R7 substituted. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R7.

[0613] In some embodiments, R5 and R6, together with the atoms to which they are attached, form a 5- to 10-membered heteroaryl group containing 1 to 4 heteroatoms selected from N, O, and S.

[0614] In some embodiments, R5 and R6, together with the atoms they are attached to, form a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S. In some embodiments, R5 and R6, together with the atoms they are attached to, form a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S.

[0615] In some embodiments, R5 and R6 together with the atoms they are attached to form piperidine, optionally substituted with one or more R7s.

[0616] In some implementations, R5 and R6 together with the atoms they are attached to form piperidine, which is replaced by one or more R7 atoms.

[0617] In some implementations, R5 and R6 together with the atoms they are attached to form piperidine, which is replaced by an R7.

[0618] In some implementations, R5 and R6 together with the atoms they are attached to form piperidine.

[0619] In some embodiments, R5 and R6 together with the atoms they are attached to form tetrahydroquinoline, optionally substituted with one or more R7s.

[0620] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydroquinoline, which is substituted with one or more R7 atoms.

[0621] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydroquinoline, with an R7 as a substitute.

[0622] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydroquinoline.

[0623] In some embodiments, R5 and R6 together with the atoms they are attached to form a tetrahydroisoquinoline, optionally substituted with one or more R7s.

[0624] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydroisoquinoline, which is substituted with one or more R7 atoms.

[0625] In some implementations, R5 and R6 together with the atoms they are attached to form a tetrahydroisoquinoline, which is replaced by an R7.

[0626] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydroisoquinoline.

[0627] In some embodiments, R5 and R6 together with the atoms they are attached to form tetrahydroimidazopyrazine, optionally substituted with one or more R7s.

[0628] In some embodiments, R5 and R6 together with the atoms they are attached to form tetrahydroimidazopyrazine, which is substituted with one or more R7s.

[0629] In some implementations, R5 and R6 together with the atoms they are attached to form a tetrahydroimidazopyrazine, which is replaced by an R7.

[0630] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydroimidazopyrazine.

[0631] In some embodiments, R5 and R6 together with the atoms they are attached to form tetrahydronaphthidine, optionally substituted with one or more R7s.

[0632] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydronaphthidine, which is substituted with one or more R7 atoms.

[0633] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydronaphthidine, which is replaced by an R7.

[0634] In some implementations, R5 and R6 together with the atoms they are attached to form tetrahydronaphthidine.

[0635] In some implementations, each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 .

[0636] In some implementations, each R7 is independently oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2. C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Alkyl groups, -NH(C 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -O-(CH2) t -R8、-NH-(CH2) t -R8, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0637] In some implementations, R7 is oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 -C(O)OR 10 -C(O)N(R) 10 2、-O-(CH2) t -R8, or -NH-(CH2) t -R8.

[0638] In some implementations, R7 is oxo, halogen, -OH, -NH2, or -CN.

[0639] In some implementations, R7 is oxo.

[0640] In some embodiments, R7 is a halogen. In some embodiments, R7 is F, Cl, Br, or I. In some embodiments, R7 is F. In some embodiments, R7 is Cl. In some embodiments, R7 is Br. In some embodiments, R7 is I.

[0641] In some embodiments, R7 is -OH. In some embodiments, R7 is -NH2. In some embodiments, R7 is -CN.

[0642] In some implementations, R7 is -C(O)R 10 -C(O)OR 10 -C(O)N(R) 10 2、-O-(CH2) t -R8, or -NH-(CH2) t -R8.

[0643] In some implementations, R7 is -C(O)R 10 In some implementations, R7 is -C(O)OR 10 In some implementations, R7 is -C(O)N(R 10 2. In some implementations, R7 is -O-(CH2). t -R8. In some implementations, R7 is -NH-(CH2). t -R8.

[0644] In some implementations, R7 is C 1-6 Alkyl groups, -NH(C 1-6 alkyl), or -N(C) 1-6 Alkyl)2.

[0645] In some implementations, R7 is C 1-6 Alkyl groups, which may optionally be substituted with one or more R groups.10 .

[0646] In some implementations, R7 is C 1-6 Alkyl groups, which are substituted with one or more R groups 10 .

[0647] In some implementations, R7 is C 1-6 Alkyl groups, which have an R substitution 10 In some implementations, R7 replaces two Rs. 10 C 1-6 Alkyl group.

[0648] In some implementations, R7 is C 1-6 Alkyloxy. In some embodiments, R7 is methoxy. In some embodiments, R7 is ethoxy. In some embodiments, R7 is propoxy. In some embodiments, R7 is butoxy. In some embodiments, R7 is pentoxy. In some embodiments, R7 is hexoxy. In some embodiments, R7 is isopropoxy. In some embodiments, R7 is isobutoxy. In some embodiments, R7 is isopentoxy. In some embodiments, R7 is isohexoxy. In some embodiments, R7 is sec-butoxy. In some embodiments, R7 is sec-pentoxy. In some embodiments, R7 is sec-hexoxy. In some embodiments, R7 is tert-butoxy.

[0649] In some implementations, R7 is -NH(C 1-6 alkyl) or -N(C) 1-6 Alkyl)2. In some embodiments, R7 is -NH(C 1-6 Alkyl group). In some embodiments, R7 is -N(C) 1-6 Alkyl)2.

[0650] In some implementations, R7 is C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, alkenyl, ynyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 .

[0651] In some implementations, R7 is C 1-3 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-10Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0652] In some implementations, R7 is C 1-3 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is optionally substituted with one or more R groups. 10 .

[0653] In some implementations, R7 is C 1-3 Alkyl groups, optionally substituted with one or more R groups 10 In some embodiments, R7 is a methyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is an ethyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is propyl, which may optionally be substituted with one or more R groups. 10 In some embodiments, R7 is isopropyl, optionally substituted with one or more R groups. 10 .

[0654] In some implementations, R7 is C 2-6 Alkenyl, which may be optionally substituted with one or more R groups 10 In some embodiments, R7 is a C2 alkenyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C3 alkenyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C4 alkenyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C5 alkenyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C6 alkenyl group, optionally substituted with one or more R groups. 10 .

[0655] In some implementations, R7 is C 2-6 The alkynyl group, which is optionally substituted with one or more R groups, 10 In some embodiments, R7 is a C2 ynyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C3 ynyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C4 ynyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C5 ynyl group, optionally substituted with one or more R groups. 10In some embodiments, R7 is a C6 ynyl group, optionally substituted with one or more R groups. 10 .

[0656] In some implementations, R7 is C 1-3 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is substituted with one or more R groups. 10 .

[0657] In some implementations, R7 is C 1-3 Alkyl groups, which are substituted with one or more R groups 10 In some embodiments, R7 is a methyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is an ethyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is propyl, which is substituted with one or more R groups. 10 In some embodiments, R7 is isopropyl, which is substituted with one or more R groups. 10 .

[0658] In some implementations, R7 is C 2-6 Alkenyl, which is substituted with one or more R 10 In some embodiments, R7 is a C2 alkenyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C3 alkenyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C4 alkenyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C5 alkenyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C6 alkenyl group, which is substituted with one or more R groups. 10 .

[0659] In some implementations, R7 is C 2-6 Alkyne group, which is substituted with one or more R groups 10 In some embodiments, R7 is a C2 ynyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C3 ynyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C4 ynyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C5 ynyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C6 ynyl group, which is substituted with one or more R groups. 10 .

[0660] In some implementations, R7 is C 1-3 Alkyl, C 2-6 alkenyl or C 2-6 Alkynyl, wherein the alkyl, alkenyl or alkynyl group is substituted with an R 10 .

[0661] In some implementations, R7 is C 1-3 Alkyl groups, which are substituted with one R 10 In some embodiments, R7 is a methyl group, which is substituted with an R. 10 In some embodiments, R7 is an ethyl group, which is substituted with an R group. 10 In some implementations, R7 is propyl, which is substituted with an R. 10 In some embodiments, R7 is isopropyl, which is substituted with an R. 10 .

[0662] In some implementations, R7 is C 2-6 Alkenyl, which has one R substitution 10 In some embodiments, R7 is a C2 alkenyl group, which is substituted with one R. 10 In some embodiments, R7 is a C3 alkenyl group, which is substituted with one R. 10 In some embodiments, R7 is a C4 alkenyl group, which is substituted with one R. 10 In some embodiments, R7 is a C5 alkenyl group, which is substituted with one R. 10 In some embodiments, R7 is a C6 alkenyl group, which is substituted with one R. 10 .

[0663] In some implementations, R7 is C 2-6 The alkynyl group has one R substitution. 10 In some embodiments, R7 is a C2 ynyl group, which is substituted with an R group. 10 In some embodiments, R7 is a C3 ynyl group, which is substituted with an R group. 10 In some embodiments, R7 is a C4 ynyl group, which is substituted with an R group. 10 In some embodiments, R7 is a C5 ynyl group, which is substituted with an R group. 10 In some embodiments, R7 is a C6 ynyl group, which is substituted with an R group. 10 .

[0664] In some implementations, R7 is C 1-3 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0665] In some implementations, R7 is C 1-3Alkyl group. In some embodiments, R7 is methyl. In some embodiments, R7 is ethyl. In some embodiments, R7 is propyl. In some embodiments, R7 is isopropyl.

[0666] In some implementations, R7 is C 2-6 Alkenyl group. In some embodiments, R7 is C2 alkenyl. In some embodiments, R7 is C3 alkenyl. In some embodiments, R7 is C4 alkenyl. In some embodiments, R7 is C5 alkenyl. In some embodiments, R7 is C6 alkenyl.

[0667] In some implementations, R7 is C 2-6 Alkynyl group. In some embodiments, R7 is C2 alkynyl. In some embodiments, R7 is C3 alkynyl. In some embodiments, R7 is C4 alkynyl. In some embodiments, R7 is C5 alkynyl. In some embodiments, R7 is C6 alkynyl.

[0668] In some implementations, R7 is C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 .

[0669] In some implementations, R7 is C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0670] In some implementations, R7 is C 3-10 Cycloalkyl or a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with one or more R atoms. 10 .

[0671] In some implementations, R7 is C 3-10 Cycloalkyl or 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S.

[0672] In some implementations, R7 is C 3-10 Cycloalkyl, which is optionally substituted with one or more R 10 .

[0673] In some embodiments, R7 is a C3 cycloalkyl group, optionally substituted with one or more R groups. 10In some embodiments, R7 is a C4 cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C5 cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C6 cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C7 cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C8 cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C9 cycloalkyl group, optionally substituted with one or more R groups. 10 In some implementations, R7 is C. 10 Cycloalkyl, which is optionally substituted with one or more R 10 .

[0674] In some embodiments, R7 is a C3-C7 monocyclic cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C3-C7 monocyclic saturated cycloalkyl group, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a C3-C7 monocyclic partially saturated cycloalkyl group, optionally substituted with one or more R groups. 10 In some implementations, R7 is C9-C. 10 Bicyclic cycloalkyl, optionally substituted with one or more R 10 In some implementations, R7 is C9-C. 10 Bicyclic saturated cycloalkyl groups, optionally substituted with one or more R groups. 10 In some implementations, R7 is C9-C. 10 Bicyclic partially saturated cycloalkyl groups, optionally substituted with one or more R groups. 10 In some implementations, R7 is C8-C. 10 Polycyclic cycloalkyl groups, optionally substituted with one or more R groups. 10 .

[0675] In some implementations, R7 is C 3-10 cycloalkyl, which is substituted with one or more R 10 .

[0676] In some embodiments, R7 is a C3 cycloalkyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C4 cycloalkyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C5 cycloalkyl group, which is substituted with one or more R groups. 10In some embodiments, R7 is a C6 cycloalkyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C7 cycloalkyl group substituted with one or more R groups. 10 In some embodiments, R7 is a C8 cycloalkyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C9 cycloalkyl group substituted with one or more R groups. 10 In some implementations, R7 is C. 10 cycloalkyl, which is substituted with one or more R 10 .

[0677] In some embodiments, R7 is a C3-C7 monocyclic cycloalkyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C3-C7 monocyclic saturated cycloalkyl group, which is substituted with one or more R groups. 10 In some embodiments, R7 is a C3-C7 monocyclic partially saturated cycloalkyl group, which is substituted with one or more R groups. 10 In some implementations, R7 is C9-C. 10 Bicyclic cycloalkyl, which is substituted with one or more R 10 In some implementations, R7 is C9-C. 10 Bicyclic saturated cycloalkyl groups, which are substituted with one or more R groups. 10 In some implementations, R7 is C9-C. 10 Bicyclic partially saturated cycloalkyl groups, which are substituted with one or more R groups. 10 In some implementations, R7 is C8-C. 10 Polycyclic alkyl groups, which are substituted with one or more R groups 10 .

[0678] In some implementations, R7 is C 3-10 Cycloalkyl, which has one R substitution 10 .

[0679] In some embodiments, R7 is a C3 cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C4 cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C5 cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C6 cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C7 cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C8 cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C9 cycloalkyl group, which is substituted with one R.10 In some implementations, R7 is C. 10 Cycloalkyl, which has one R substitution 10 .

[0680] In some embodiments, R7 is a C3-C7 monocyclic cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C3-C7 monocyclic saturated cycloalkyl group, which is substituted with one R. 10 In some embodiments, R7 is a C3-C7 monocyclic partially saturated cycloalkyl group, which is substituted with one R. 10 In some implementations, R7 is C9-C. 10 Bicyclic cycloalkyl, which has one R substitution 10 In some implementations, R7 is C9-C. 10 Bicyclic saturated cycloalkyl groups, which are substituted with one R 10 In some implementations, R7 is C9-C. 10 Bicyclic partially saturated cycloalkyl groups, which have one R substitution. 10 In some implementations, R7 is C8-C. 10 Polycyclic alkyl groups, whose substitution has one R 10 .

[0681] In some implementations, R7 is C 3-10 Cycloalkyl.

[0682] In some embodiments, R7 is a C3 cycloalkyl group. In some embodiments, R7 is a C4 cycloalkyl group. In some embodiments, R7 is a C5 cycloalkyl group. In some embodiments, R7 is a C6 cycloalkyl group. In some embodiments, R7 is a C7 cycloalkyl group. In some embodiments, R7 is a C8 cycloalkyl group. In some embodiments, R7 is a C9 cycloalkyl group. In some embodiments, R7 is a C... 10 Cycloalkyl.

[0683] In some embodiments, R7 is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R7 is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R7 is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R7 is a C9-C7 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl. In some embodiments, R7 is C9-C. 10 Bicyclic saturated cycloalkyl group. In some embodiments, R7 is C9-C. 10 Bicyclic partially saturated cycloalkyl group. In some embodiments, R7 is C8-C6. 10 Polycyclic cycloalkyl groups.

[0684] In some embodiments, R7 is a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 .

[0685] In some embodiments, R7 is a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms.10 In some embodiments, R7 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 .

[0686] In some embodiments, R7 is a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substituted. 10 In some embodiments, R7 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substituted. 10 In some embodiments, R7 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substituted. 10 In some embodiments, R7 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substituted. 10 In some embodiments, R7 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substituted. 10 In some embodiments, R7 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, with one R substituted. 10 .

[0687] In some embodiments, R7 is a 3- to 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 3-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 4-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 5-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0688] In some implementations, R7 is C 6-10 aryl or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl group is optionally substituted with one or more R atoms. 10 .

[0689] In some implementations, R7 is C 6-10 Aryl or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0690] In some implementations, R7 is C 6-10 aryl, which may be optionally substituted with one or more R 10 .

[0691] In some implementations, R7 is C 6-8 aryl, which may be optionally substituted with one or more R 10 In some embodiments, R7 is a phenyl group, optionally substituted with one or more R groups. 10 .

[0692] In some implementations, R7 is C 6-8 aryl, which is substituted with one or more R 10 In some embodiments, R7 is a phenyl group, which is substituted with one or more R groups. 10 .

[0693] In some implementations, R7 is C 6-8 aryl, which has a substitution R 10 In some embodiments, R7 is a phenyl group, which is substituted with an R. 10 .

[0694] In some implementations, R7 is C 6-10 Aryl.

[0695] In some implementations, R7 is C 6-8 Aryl. In some embodiments, R7 is phenyl.

[0696] In some embodiments, R7 is a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R groups. 10 In some embodiments, R7 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 In some embodiments, R7 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R atoms. 10 .

[0697] In some embodiments, R7 is a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms. 10 In some embodiments, R7 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R atoms.10 .

[0698] In some embodiments, R7 is a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 In some embodiments, R7 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, with one R substitution. 10 .

[0699] In some embodiments, R7 is a 5- to 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R7 is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0700] In some embodiments, R7 is cyclopropyl, piperidine, tetrahydropyran, morpholine, phenyl, pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0701] In some implementations, R7 is cyclopropyl, piperidine, tetrahydropyran, or morpholine.

[0702] In some embodiments, R7 is phenyl, pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0703] In some embodiments, R7 is pyridine, pyrimidine, tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0704] In some implementations, R7 is pyridine or pyrimidine.

[0705] In some embodiments, R7 is tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazolium, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxadiene, benzo[d]oxazole-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0706] In some implementations, R7 is tetrazolium, triazole, pyrazole, thiazole, oxazole, furan, pyrrole, isoxazole, or imidazole.

[0707] In some embodiments, R7 is 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxanediene, benzo[d]oxazol-2(3H)-one, benzo[d]isoxazole, or 9H-carbazole.

[0708] In some embodiments, R7 is 1,3-dihydro-2H-benzo[d]imidazol-2-one, indoline, indole, 2,3-dihydrobenzofuran, 1H-benzo[d][1,2,3]triazole, 1H-indazole, imidazo[1,2-a]pyrazine, naphthalene, quinoline, 2,3-dihydrobenzo[b][1,4]dioxane, or benzo[d]oxazol-2(3H)-one, benzo[d]isoxazole.

[0709] In some implementations, R7 is 9H-carbazole.

[0710] In some implementations, R7 is oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 C 1-6 Alkyl, C 2-6 Alkyne group, -O-(CH2) t -R8,C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, ynyl, aryl, or heteroaryl group is optionally substituted with one or more R atoms. 10 .

[0711] In some implementations, R7 is oxo, halogen, -OH, -NH2, -CN, or -C(O)R. 10 C 1-6 Alkyl, C 2-6 Alkyne group, -O-(CH2) t -R8,C 6-10 aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkyl, ynyl, aryl, or heteroaryl group is substituted with one or more R atoms. 10 .

[0712] In some implementations, R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s.

[0713] In some implementations, R8 is -OH, C 1-6 Alkoxy, C 1-6Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 Alkyl), C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0714] In some implementations, R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -SH, or -S(C 1-6 Alkyl), wherein the alkoxy or alkyl group is optionally substituted with one or more R9s.

[0715] In some implementations, R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -SH, or -S(C 1-6 Alkyl), wherein the alkoxy or alkyl is substituted with one or more R9.

[0716] In some implementations, R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl group 2, -SH, or -S(C 1-6 Alkyl), wherein the alkoxy or alkyl substitution has an R9.

[0717] In some implementations, R8 is C 1-6 Alkyl group, which may optionally be substituted with one or more R9s.

[0718] In some implementations, R8 is C 1-6 Alkoxy-OH, wherein the alkoxy group is optionally substituted with one or more R9s.

[0719] In some implementations, R8 is C 1-6 Alkyl groups, which are substituted with one or more R9s.

[0720] In some implementations, R8 is C 1-6 Alkoxy-OH, wherein the alkoxy group is substituted with one or more R9s.

[0721] In some implementations, R8 replaces C which has an R9. 1-6 Alkyl group.

[0722] In some implementations, R8 is C 1-6 Alkoxy-OH, wherein the alkoxy group is substituted with an R9.

[0723] In some implementations, R8 is -NH(C 1-6 Alkyl group), wherein the alkyl group is optionally substituted with one or more R9s.

[0724] In some implementations, R8 is -N(C 1-6 Alkyl)2, wherein the alkyl group is optionally substituted with one or more R9s.

[0725] In some implementations, R8 is -NH(C 1-6 Alkyl), wherein the alkyl group is substituted with one or more R9.

[0726] In some implementations, R8 is -N(C 1-6 Alkyl)2, wherein the alkyl group is substituted with one or more R9.

[0727] In some implementations, R8 is -NH(C 1-6 Alkyl), wherein the alkyl is substituted with one R9.

[0728] In some implementations, R8 is -N(C 1-6 Alkyl)2, wherein the alkyl is substituted with one R9.

[0729] In some implementations, R8 is -S(C 1-6 Alkyl group), wherein the alkyl group is optionally substituted with one or more R9s.

[0730] In some implementations, R8 is -S(C 1-6 Alkyl), wherein the alkyl group is substituted with one or more R9.

[0731] In some implementations, R8 is -S(C 1-6 Alkyl), wherein the alkyl is substituted with one R9.

[0732] In some implementations, R8 is -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -NH(C) 1-6 alkyl), -N(C) 1-6 Alkyl)2, -SH, -S(C 1-6 alkyl).

[0733] In some implementations, R8 is -OH, C 1-6 Alkoxy or C 1-6 Alkyl group -OH.

[0734] In some implementations, R8 is -OH.

[0735] In some implementations, R8 is C 1-6 Alkyloxy. In some embodiments, R8 is methoxy. In some embodiments, R8 is ethoxy. In some embodiments, R8 is propoxy. In some embodiments, R8 is butoxy. In some embodiments, R8 is pentoxy. In some embodiments, R8 is hexoxy. In some embodiments, R8 is isopropoxy. In some embodiments, R8 is isobutoxy. In some embodiments, R8 is isopentoxy. In some embodiments, R8 is isohexoxy. In some embodiments, R8 is sec-butoxy. In some embodiments, R8 is sec-pentoxy. In some embodiments, R8 is sec-hexoxy. In some embodiments, R8 is tert-butoxy.

[0736] In some implementations, R8 is C 1-6 Alkyloxy-OH. In some embodiments, R8 is methoxy-OH. In some embodiments, R8 is ethoxy-OH. In some embodiments, R8 is propoxy-OH. In some embodiments, R8 is butoxy-OH. In some embodiments, R8 is pentoxy-OH. In some embodiments, R8 is hexoxy-OH. In some embodiments, R8 is isopropoxy-OH. In some embodiments, R8 is isobutoxy-OH. In some embodiments, R8 is isopentoxy-OH. In some embodiments, R8 is isohexoxy-OH. In some embodiments, R8 is sec-butoxy-OH. In some embodiments, R8 is sec-pentoxy-OH. In some embodiments, R8 is sec-hexoxy-OH. In some embodiments, R8 is tert-butoxy-OH.

[0737] In some implementations, R8 is -NH2, -NH(C 1-6 alkyl), or -N(C) 1-6 Alkyl)2.

[0738] In some implementations, R8 is -NH2.

[0739] In some implementations, R8 is -NH(C 1-6Alkyl group). In some embodiments, R8 is -NH (methyl). In some embodiments, R8 is -NH (ethyl). In some embodiments, R8 is -NH (propyl). In some embodiments, R8 is -NH (butyl). In some embodiments, R8 is -NH (pentyl). In some embodiments, R8 is -NH (hexyl). In some embodiments, R8 is -NH (isopropyl). In some embodiments, R8 is -NH (isobutyl). In some embodiments, R8 is -NH (isopentyl). In some embodiments, R8 is -NH (isohexyl). In some embodiments, R8 is -NH (sec-butyl). In some embodiments, R8 is -NH (sec-pentyl). In some embodiments, R8 is -NH (sec-hexyl). In some embodiments, R8 is -NH (tert-butyl).

[0740] In some implementations, R8 is -N(C 1-6 Alkyl)2. In some embodiments, R8 is -N(methyl)2. In some embodiments, R8 is -N(ethyl)2. In some embodiments, R8 is -N(propyl)2. In some embodiments, R8 is -N(butyl)2. In some embodiments, R8 is -N(pentyl)2. In some embodiments, R8 is -N(hexyl)2. In some embodiments, R8 is -N(isopropyl)2. In some embodiments, R8 is -N(isobutyl)2. In some embodiments, R8 is -N(isopentyl)2. In some embodiments, R8 is -N(isohexyl)2. In some embodiments, R8 is -N(sec-butyl)2. In some embodiments, R8 is -N(sec-pentyl)2. In some embodiments, R8 is -N(sec-hexyl)2. In some embodiments, R8 is -N(tert-butyl)2.

[0741] In some implementations, R8 is -SH or -S(C 1-6 alkyl).

[0742] In some implementations, R8 is -SH.

[0743] In some implementations, R8 is -S(C 1-6 alkyl).

[0744] In some embodiments, R8 is -S (methyl). In some embodiments, R8 is -S (ethyl). In some embodiments, R8 is -S (propyl). In some embodiments, R8 is -S (butyl). In some embodiments, R8 is -S (pentyl). In some embodiments, R8 is -S (hexyl). In some embodiments, R8 is -S (isopropyl). In some embodiments, R8 is -S (isobutyl). In some embodiments, R8 is -S (isopentyl). In some embodiments, R8 is -S (isohexyl). In some embodiments, R8 is -S (sec-butyl). In some embodiments, R8 is -S (sec-pentyl). In some embodiments, R8 is -S (sec-hexyl). In some embodiments, R8 is -S (tert-butyl).

[0745] In some implementations, R8 is C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or a 5- to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the cycloalkyl, heterocyclic, aryl, or heteroaryl group is optionally substituted with one or more R9s.

[0746] In some implementations, R8 is C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0747] In some implementations, R8 is C 3-10 Cycloalkyl or a 3- to 10-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the cycloalkyl or heterocyclic group is optionally substituted with one or more R9s.

[0748] In some implementations, R8 is C 3-10 Cycloalkyl or 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S.

[0749] In some implementations, R8 is C 3-10 Cycloalkyl, optionally substituted with one or more R9s.

[0750] In some embodiments, R8 is a C3 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C4 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C5 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C6 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C7 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C8 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C9 cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C... 10 Cycloalkyl, optionally substituted with one or more R9s.

[0751] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is a C9-C9 cycloalkyl group. 10 Bicyclic cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is C9-C6. 10 A bicyclic saturated cycloalkyl group, optionally substituted with one or more R9s. In some embodiments, R8 is C9-C6. 10 The bicyclic partially saturated cycloalkyl group is optionally substituted with one or more R9s. In some embodiments, R8 is C8-C9. 10 Polycyclic cycloalkyl groups, optionally substituted with one or more R9s.

[0752] In some implementations, R8 is C 3-10 Cycloalkyl, which is substituted with one or more R9s.

[0753] In some embodiments, R8 is a C3 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C4 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C5 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C6 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C7 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C8 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C9 cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C... 10 Cycloalkyl, which is substituted with one or more R9s.

[0754] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one or more R9s. In some embodiments, R8 is a C9-C9 monocyclic cycloalkyl group. 10 Bicyclic cycloalkyl group, wherein one or more R8s are substituted. In some embodiments, R8 is C9-C6. 10 A bicyclic saturated cycloalkyl group, substituted with one or more R9s. In some embodiments, R8 is C9-C6. 10 The bicyclic partially saturated cycloalkyl group is substituted with one or more R9s. In some embodiments, R8 is C8-C9. 10 Polycyclic alkyl groups, which are substituted with one or more R9s.

[0755] In some implementations, R8 is C 3-10 Cycloalkyl, which has one R9 substitution.

[0756] In some embodiments, R8 is a C3 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C4 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C5 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C6 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C7 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C8 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C9 cycloalkyl group substituted with one R9. In some embodiments, R8 is a C... 10 Cycloalkyl, which has one R9 substitution.

[0757] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group substituted with one R9. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group substituted with one R9. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group substituted with one R9. In some embodiments, R8 is a C9-C9 cycloalkyl group. 10 Bicyclic cycloalkyl group, wherein one of the substitutions is R9. In some embodiments, R8 is C9-C. 10 A bicyclic saturated cycloalkyl group, wherein one of the substitutions is R9. In some embodiments, R8 is C9-C. 10 The bicyclic partially saturated cycloalkyl group has one R9 substituted. In some embodiments, R8 is C8-C9. 10 Polycyclic cycloalkyl groups, with one of the substitutions being R9.

[0758] In some implementations, R8 is C 3-10 Cycloalkyl.

[0759] In some embodiments, R8 is a C3 cycloalkyl group. In some embodiments, R8 is a C4 cycloalkyl group. In some embodiments, R8 is a C5 cycloalkyl group. In some embodiments, R8 is a C6 cycloalkyl group. In some embodiments, R8 is a C7 cycloalkyl group. In some embodiments, R8 is a C8 cycloalkyl group. In some embodiments, R8 is a C9 cycloalkyl group. In some embodiments, R8 is a C... 10 Cycloalkyl.

[0760] In some embodiments, R8 is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R8 is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R8 is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R8 is a C9-C6 group. 10 Bicyclic cycloalkyl. In some embodiments, R8 is C9-C. 10 Bicyclic saturated cycloalkyl group. In some embodiments, R8 is C9-C6. 10 Bicyclic partially saturated cycloalkyl group. In some embodiments, R8 is C8-C6. 10 Polycyclic cycloalkyl groups.

[0761] In some embodiments, R8 is a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s.

[0762] In some embodiments, R8 is a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s.

[0763] In some embodiments, R8 is a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 3-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 4-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 5-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 6-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 7-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is an 8-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 9-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9.

[0764] In some embodiments, R8 is a 3- to 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 3-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 4-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 5-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 6-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 7-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is an 8-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 9-membered heterocyclic group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 10-membered heterocyclic group containing 1-4 heteroatoms selected from N, O and S.

[0765] In some implementations, R8 is C 6-10 Aryl or 5- to 10-membered heteroaryl groups comprising 1 to 4 heteroatoms selected from N, O, and S, wherein the aryl or heteroaryl group is optionally substituted with one or more R9 atoms.

[0766] In some implementations, R8 is C 6-10 Aryl or 5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S.

[0767] In some implementations, R8 is C 6-10 Aryl, which may optionally be substituted with one or more R9s.

[0768] In some implementations, R8 is C 6-8 The aryl group is optionally substituted with one or more R9s. In some embodiments, R8 is a phenyl group optionally substituted with one or more R9s.

[0769] In some implementations, R8 is C 6-8 Aryl group, which is substituted with one or more R9s. In some embodiments, R8 is a phenyl group, which is substituted with one or more R9s.

[0770] In some implementations, R8 is C 6-8 The aryl group is substituted with one R9. In some embodiments, R8 is a phenyl group substituted with one R9.

[0771] In some implementations, R8 is C 6-10 Aryl.

[0772] In some implementations, R8 is C 6-8 Aryl. In some embodiments, R8 is phenyl.

[0773] In some embodiments, R8 is a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, optionally substituted with one or more R9s. In some embodiments, R8 is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more R9s.

[0774] In some embodiments, R8 is a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one or more R9s. In some embodiments, R8 is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S, substituted with one or more R9s.

[0775] In some embodiments, R8 is a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 5-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 6-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 7-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is an 8-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 9-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9. In some embodiments, R8 is a 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, substituted with one R9.

[0776] In some embodiments, R8 is a 5- to 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S. In some embodiments, R8 is a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S.

[0777] In some implementations, R8 is H, -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -N(C) 1-6 alkyl)2、-S(C 1-6 Alkyl group, 3 to 10-membered heterocyclic group comprising 1 to 4 heteroatoms selected from N, O and S, or 5 to 10-membered heteroaryl group comprising 1 to 4 heteroatoms selected from N, O and S, wherein the alkoxy, alkyl, heterocyclic or heteroaryl group is optionally substituted with one or more R9.

[0778] In some implementations, R8 is H, -OH, C 1-6 Alkoxy, C 1-6 Alkyl groups -OH, -NH2, -N(C) 1-6 alkyl)2、-S(C 1-6An alkyl group, a 3- to 10-membered heterocyclic group comprising 1-4 heteroatoms selected from N, O, and S, or a 5- to 10-membered heteroaryl group comprising 1-4 heteroatoms selected from N, O, and S, wherein the alkoxy, alkyl, heterocyclic, or heteroaryl group is substituted with one or more R9s.

[0779] In some implementations, each R9 is independently -(CH2). u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2.

[0780] In some implementations, R9 is -(CH2). u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl).

[0781] In some implementations, R9 is -(CH2). u - (containing 1 to 4 heteroatoms selected from N, O and S, consisting of 5 to 10 heteroaryl groups), wherein the heteroaryl groups are optionally substituted with one or more halogens, -CN, -OH, or -NH2.

[0782] In some implementations, R9 is -(CH2). u -(5-membered heteroaryl), wherein the heteroaryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(6-heteroaryl), wherein the heteroaryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(7-heteroaryl), wherein the heteroaryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(8-heteroaryl), wherein the heteroaryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(9-heteroaryl), wherein the heteroaryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(10-heteroaryl), wherein the heteroaryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2.

[0783] In some implementations, R9 is -(CH2). u - (containing 1 to 4 heteroatoms selected from N, O and S, consisting of 5 to 10 heteroaryl groups), wherein the heteroaryl groups are substituted with one or more halogens, -CN, -OH, or -NH2.

[0784] In some implementations, R9 is -(CH2). u - (a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S), wherein the heteroaryl group is substituted with one or more halogens, -CN, -OH or -NH2.

[0785] In some implementations, R9 is -(CH2). u - (containing 1 to 4 heteroatoms selected from N, O and S, of which the heteroaryl group is substituted with a halogen, -CN, -OH or -NH2).

[0786] In some implementations, R9 is -(CH2). u - (a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u- (a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S), wherein the heteroaryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u - (a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S), wherein the heteroaryl group is substituted with a halogen, -CN, -OH or -NH2.

[0787] In some implementations, R9 is -(CH2). u -(5- to 10-membered heteroaryl groups containing 1 to 4 heteroatoms selected from N, O, and S).

[0788] In some implementations, R9 is -(CH2). u -(a 5-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2). u -(a 6-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2). u -(a 7-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2). u -(an 8-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2). u -(a 9-membered heteroaryl group containing 1-4 heteroatoms selected from N, O, and S). In some embodiments, R9 is -(CH2). u -(a 10-membered heteroaryl group containing 1-4 heteroatoms selected from N, O and S).

[0789] In some implementations, R9 is -(CH2). u -(C 6-10(Aryl), wherein the aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(C 6-8 (Aryl), wherein the aryl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(phenyl), wherein the phenyl group is optionally substituted with one or more halogens, -CN, -OH, or -NH2.

[0790] In some implementations, R9 is -(CH2). u -(C 6-10 (Aryl), wherein the aryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(C 6-8 (Aryl), wherein the aryl group is substituted with one or more halogens, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(phenyl), wherein the phenyl group is substituted with one or more halogens, -CN, -OH, or -NH2.

[0791] In some implementations, R9 is -(CH2). u -(C 6-10 (Aryl), wherein the aryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(C 6-8 (Aryl), wherein the aryl group is substituted with a halogen, -CN, -OH, or -NH2. In some embodiments, R9 is -(CH2). u -(phenyl), wherein the phenyl group is substituted with more than one halogen, -CN, -OH, or -NH2.

[0792] In some implementations, R9 is -(CH2). u -(C 6-10 (Aryl). In some embodiments, R9 is -(CH2). u -(C 6-8 (Aryl). In some embodiments, R9 is -(CH2). u -(phenyl).

[0793] In some implementations, R9 is -(CH2). u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10Aryl), wherein the heteroaryl or aryl group is optionally substituted with one or more halogens or -OH.

[0794] In some implementations, R9 is -(CH2). u -(5- to 10-membered heteroaryl groups containing 1-4 heteroatoms selected from N, O, and S) or -(CH2) u -(C 6-10 Aryl), wherein the heteroaryl or aryl group is substituted with one or more halogens or -OH.

[0795] In some implementation schemes, each R 10 Independently halogen, -OH, -NH2, -CN, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0796] In some implementation schemes, R 10 It can be a halogen, -OH, -NH2, or -CN.

[0797] In some implementation schemes, R 10 It is a halogen.

[0798] In some implementation schemes, R 10 It can be F, Cl, Br, or I. In some implementations, R 10 It can be F, Cl, or Br.

[0799] In some implementation schemes, R 10 For F. In some implementations, R 10 For Cl. In some implementations, R 10 For Br. In some implementations, R 10 For I.

[0800] In some implementation schemes, R 10 For -OH. In some implementations, R 10 For -NH2. In some implementations, R 10 For -CN.

[0801] In some implementation schemes, R 10 C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 1-6 Haloalkyl, C 3-10Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0802] In some implementation schemes, R 10 C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl or C 1-6 Halogenated alkyl groups.

[0803] In some implementation schemes, R 10 C 1-6 Alkyl, C 2-6 alkenyl or C 2-6 Alkyne group.

[0804] In some implementation schemes, R 10 C 1-6 Alkyl group. In some embodiments, R 10 It is methyl. In some embodiments, R 10 It is ethyl. In some embodiments, R 10 It is propyl. In some embodiments, R 10 For butyl. In some implementations, R 10 It is pentyl. In some implementations, R 10 For its own foundation. In some implementation schemes, R 10 It is isopropyl. In some embodiments, R 10 It is isobutyl. In some embodiments, R 10 It is isopentyl. In some embodiments, R 10 It is an allotropic group. In some implementations, R 10 It is sec-butyl. In some implementations, R 10 It is sec-amyl. In some implementations, R 10 For Zhongjiji. In some implementations, R 10 It is tert-butyl.

[0805] In some implementation schemes, R 10 C 2-6 Alkenyl. In some embodiments, R 10 It is C2-olefinic. In some embodiments, R 10 It is a C3 alkenyl group. In some embodiments, R 10 It is a C4 alkenyl group. In some embodiments, R 10 It is a C5 alkenyl group. In some embodiments, R 10 It is a C6 alkenyl group.

[0806] In some implementation schemes, R10 C 2-6 Alkyne group. In some embodiments, R 10 It is a C2 acetylene group. In some embodiments, R 10 It is a C3 acetyl group. In some embodiments, R 10 It is a C4 acetylene group. In some embodiments, R 10 It is a C5 acetyl group. In some embodiments, R 10 It is a C6 acetylene group.

[0807] In some implementation schemes, R 10 C 1-6 Halogenated alkyl groups. In some embodiments, R 10 It is a halomethyl group. In some embodiments, R 10 It is a haloethyl. In some embodiments, R 10 It is a halogenated propyl group. In some embodiments, R 10 It is a halogenated butyl. In some embodiments, R 10 It is a halopentyl group. In some embodiments, R 10 Halogenated hexyl.

[0808] In some implementation schemes, R 10 C 3-10 Cycloalkyl groups, 3- to 10-membered heterocyclic groups containing 1-4 heteroatoms selected from N, O, and S, C 6-10 Aryl, or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms selected from N, O, and S.

[0809] In some implementation schemes, R 10 C 3-10 Cycloalkyl or 3- to 10-membered heterocyclic groups containing 1 to 4 heteroatoms selected from N, O and S.

[0810] In some implementation schemes, R 10 C 3-10 Cycloalkyl.

[0811] In some implementation schemes, R 10 It is a C3 cycloalkyl group. In some embodiments, R 10 It is a C4 cycloalkyl group. In some embodiments, R 10 It is a C5 cycloalkyl group. In some embodiments, R 10 It is a C6 cycloalkyl group. In some embodiments, R 10 It is a C7 cycloalkyl group. In some embodiments, R 10 It is a C8 cycloalkyl group. In some embodiments, R 10 It is a C9 cycloalkyl group. In some embodiments, R 10 C 10 Cycloalkyl.

[0812] In some implementation schemes, R 10 It is a C3-C7 monocyclic cycloalkyl group. In some embodiments, R 10 It is a C3-C7 monocyclic saturated cycloalkyl group. In some embodiments, R 10 It is a C3-C7 monocyclic partially saturated cycloalkyl group. In some embodiments, R 10 For C9-C 10 Bicyclic cycloalkyl. In some embodiments, R 10 For C9-C 10 Bicyclic saturated cycloalkyl. In some embodiments, R 10 For C9-C 10 Bicyclic partially s...

Claims

1. A compound selected from the following compounds shown in Table 1 and Table 2, or a pharmaceutically acceptable tautomer or pharmaceutically acceptable salt thereof: Compound 2: Compound 4: Compound 7: Compound 11: Compound 13: Compound 17: Compound 23: Compound 28:

2. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable tautomer or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.

3. A compound of claim 1 or a pharmaceutical composition of claim 2 for use in modulating P-glycoprotein and / or cytochrome P450 activity.

4. A compound of claim 1 or a pharmaceutical composition of claim 2 for use in the treatment or prevention of a disease or disorder susceptible to inhibition of P-glycoprotein and / or cytochrome P450 activity.

5. Use of a compound of claim 1 or a pharmaceutical composition of claim 2 in the manufacture of a medicament for modulating P-glycoprotein and / or cytochrome P450 activity.

6. Use of a compound of claim 1 or a pharmaceutical composition of claim 2 in the manufacture of a medicament for the treatment or prevention of a disease or disorder susceptible to inhibition of P-glycoprotein and / or cytochrome P450 activity.

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