A soothing anti-sensitivity composition, method of preparation and use thereof

Abstract

The application discloses a soothing and anti-allergic composition and a preparation method and application thereof. The soothing and anti-allergic composition comprises the following components in parts by weight: sea salt 0.001-5.0 parts; hydrolyzed seaweed extract 0.001-3.0 parts; Illicium micranthum leaf extract 0.001-5.0 parts; and polysaccharide 0.001-1.0 part. The soothing and anti-allergic composition is composed of sea salt containing rich mineral elements, hydrolyzed seaweed extract capable of promoting blood circulation, Illicium micranthum leaf extract capable of inhibiting TRPV1 expression and polysaccharide capable of improving skin activity. The sea salt, the polysaccharide, the Illicium micranthum leaf extract and the hydrolyzed seaweed extract have a synergistic effect, and can achieve unexpected effects of instant soothing and continuous alleviation of allergic symptoms.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of cosmetics, in particular to a soothing anti-allergy composition and its preparation method and application. BACKGROUND

[0002] Sensitive skin refers to a high reaction state of skin under physiological or pathological conditions, mainly occurring on the face, and is clinically manifested as subjective symptoms such as burning, stinging, itching and tightness, or accompanied by objective signs such as erythema, scales and telangiectasia when the skin is stimulated by physical, chemical, mental and other factors. Due to the complexity of the causes and mechanisms of sensitive skin, it may be related to factors such as damage to skin barrier function, inflammatory response, increased nerve sensitivity and abnormal sebum changes. There is no specific treatment method at present. In general, it is caused by the combined action of internal and external factors, resulting in damage to the skin barrier function, increased sensory nerve signal input and enhanced immune response, leading to the occurrence of sensitive skin.

[0003] In September 2021, the Nobel Prize in Physiology or Medicine was awarded to American scientists David Julius and Ardem Patapoutian for their contribution to the discovery of temperature and touch receptors. In order to explore how capsaicin causes a sense of pain, Julius and his colleagues created a library consisting of millions of DNA fragments, and after repeated attempts, they finally identified a gene that can make cells sensitive to capsaicin. Further experiments showed that the identified gene encodes a new ion channel protein, which was later named TRPV1. The discovery of TRPV1 ion channel has opened up a path to uncover other temperature sensing receptors. This discovery has also been used to develop treatments for various diseases. For example, the burning and stinging sensation is caused by the overexpression of the heat receptor TRPV1 (transient receptor potential vanilloid 1).

[0004] At present, many anti-allergy cosmetics on the market only target a certain immune response source in the body to achieve the effect of preventing and treating sensitivity, such as anti-histamine, many cosmetics on the market add ingredients such as oat alkaloids and chitin to achieve the effect of preventing and treating sensitivity. The mechanism of such products is not comprehensive enough, and it is difficult to be suitable for most people with sensitive skin. Moreover, most anti-allergy products do not effectively target the discomfort caused by nerve signal transmission, and the consumers' burning sensation and pain do not decrease, and the consumers need to use it for a period of time before the symptoms are alleviated, and the pain can be reduced. SUMMARY

[0005] In order to overcome the problems existing in the prior art, one of the purposes of the present application is to provide a soothing anti-allergy composition.

[0006] The second object of the present application is to provide a preparation method of the soothing and anti-allergic composition.

[0007] The third object of the present application is to provide a soothing and anti-allergic skin care product.

[0008] The fourth object of the present application is to provide an application of the soothing and anti-allergic composition in the field of cosmetics.

[0009] To achieve the above objects, the technical solution adopted by the present application is:

[0010] The first aspect of the present application is to provide a soothing and anti-allergic composition, comprising the following components in parts by weight: sea salt 0.001-5.0 parts; hydrolyzed algal extract 0.001-3.0 parts; Illicium micranthum leaf extract 0.001-5.0 parts; polysaccharide 0.001-1.0 parts.

[0011] Preferably, the soothing and anti-allergic composition comprises the following components in parts by weight: sea salt 0.001-1.0 parts; hydrolyzed algal extract 0.01-1.0 parts; Illicium micranthum leaf extract 0.01-3.0 parts; polysaccharide 0.005-0.5 parts.

[0012] Preferably, the polysaccharide is selected from at least one of Schizophyllan, β-glucan.

[0013] Preferably, the sea salt comprises the following ingredients: sodium ion, calcium ion, magnesium oxide, sulfate ion.

[0014] The second aspect of the present application is to provide a preparation method of the soothing and anti-allergic composition provided by the first aspect of the present application, comprising the following steps: mixing the components to obtain the soothing and anti-allergic composition. The preparation method of the soothing and anti-allergic composition in the present application is simple and easy to operate, and can be applied to mass industrial production.

[0015] The third aspect of the present application is to provide a soothing and anti-allergic skin care product, comprising the soothing and anti-allergic composition provided by the first aspect of the present application.

[0016] Preferably, in the skin care product, the mass percentage of the soothing and anti-allergic composition is 0.004-14%.

[0017] Preferably, in the skin care product, the mass percentage of the soothing and anti-allergic composition is 0.026-5.5%.

[0018] Preferably, the skin care product comprises a spray, a toner, an essence, a lotion, a cream or a mask.

[0019] The above-mentioned skin care product has all the characteristics and advantages of the soothing and anti-allergic composition in the present application.

[0020] The fourth aspect of the present application provides the use of the soothing and anti-allergic composition provided by the first aspect of the present application in the field of cosmetics.

[0021] The present application has the following advantages: the soothing and anti-allergic composition of the present application is composed of sea salt containing rich mineral elements, hydrolyzed seaweed extract promoting blood circulation, schizophyllan or beta-glucan improving skin activity, and Illicium micranthum leaf extract inhibiting TRPV1 expression, and the sea salt, the polysaccharide, the Illicium micranthum leaf extract, and the hydrolyzed seaweed extract have a synergistic effect on each other, achieving unexpected effects of instant soothing and continuous relief of allergic symptoms. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure 1 Figure 2 is a graph of the relationship between the skin blood cell concentration change value and time in Experiment 1. DETAILED DESCRIPTION

[0023] The specific embodiments of the present application are further described in detail below with reference to the accompanying drawings and examples, but the implementation and protection of the present application are not limited thereto. It should be noted that if the following processes are not specifically described in detail, they can be implemented or understood by those skilled in the art with reference to the prior art. If the reagents or instruments used are not marked with the manufacturer, they are considered to be conventional products that can be purchased on the market.

[0024] The following is an introduction to the raw materials and related mechanisms of the present application:

[0025] Illicium micranthum is a high mountain plant, and the Illicium micranthum leaf extract is a water-soluble component containing waterweed dials, anthocyanins, and rutin, which can reduce the release of inflammatory mediators, interleukin-1α, and prostaglandin E2 by inhibiting the activation of TRPV1 channel, thereby achieving the effect of soothing skin sensitivity, itching, and stinging. The Illicium micranthum leaf extract can eliminate or reduce inflammatory factors, and can reduce skin irritation, so it has the effects of anti-inflammation and skin soothing. The Illicium micranthum leaf extract used in the examples and comparative examples of the present application is sourced from LUCAS MAYER.

[0026] Sea salt is rich in minerals, which promote blood circulation and metabolism in the skin. For example, sodium ions can regulate and maintain osmotic pressure in the extracellular fluid, thus affecting cell function; calcium is an important cation in both intracellular and extracellular fluid, existing in plasma as complexed polypeptides, which can activate thrombin, enhance nerve inhibition processes, increase blood vessel density, stimulate the sympathetic nervous system to increase excitability, densify capillary walls, reduce capillary and cell permeability, thereby reducing exudate, stimulating the myocardium and muscular system, regulating muscle tension, and promoting the repair of damaged tissues; magnesium salts can bind with water, affecting epidermal proliferation and differentiation and accelerating the repair of the permeable barrier, thus improving skin barrier function, increasing the hydration of the stratum corneum, and reducing skin roughness and inflammation; and SO42-... 2- S in 2+ It can partially dissociate, causing peripheral vasodilation, oxidizing pathological products, softening damaged skin, and promoting the resolution of inflammation. It also helps in mild pain relief and improves skin vasodilation and surface blood circulation. - It has a strong bactericidal effect; a concentration of 0.02 mg / L in the air is sufficient to kill various microorganisms. It also has an oxidizing effect on tissues, softening scar tissue. The sea salt used in the embodiments and comparative examples of this invention is derived from ODYCEA and contains calcium ions, magnesium ions, sulfate ions, and sodium ions.

[0027] Seaweed is one of the oldest plants in the world, without roots, flowers, or fruits. The organic iodine in seaweed extract has a lipolysis-regulating effect, while the mineral salts and polysaccharides in seaweed stimulate blood circulation. The hydrophilic properties of the alginate in the hydrolyzed seaweed extract protect the hydrophilic and lipophilic outer layer. The hydrolyzed seaweed extract used in the embodiments and comparative examples of this invention is sourced from Symrise Fragrance & Flavor (Nantong) Co., Ltd.

[0028] Schizophyllan polysaccharide Schizophyllian (SPG) is a water-soluble polysaccharide extracted from the fruiting body, mycelium, or fermentation broth of Schizophyllum commune. Its structure consists of a β-(1-3) glycoside as the main chain and a β-(1-6) glycoside as the side chain. SPG has various physiological activities such as inhibiting tumors, antibacterial and anti-inflammatory effects, anti-radiation effects, and improving the body's immunity.

[0029] The polysaccharides (including Schizophyllum commune polysaccharide and β-glucan) are sourced from Guangzhou Nuowei Biotechnology Co., Ltd.

[0030] MONTANOV L is derived from SEPPIC SA. Montano L emulsifier is an oil-in-water emulsifier, and its INCI name is: C14-22 alcohol / C12-20 alkyl glucoside. It is a white granular solid.

[0031] Edenor C18-65 MY is derived from Emery Oleochemicals (M) Sdn Bhd, and the trade name is stearic acid Edenor C18-65.

[0032] In order to facilitate the study of the soothing and anti-allergic effect of the soothing and anti-allergic composition in the present application, the soothing and anti-allergic composition is added to the basic skin care formula, specifically: different proportions of soothing and anti-allergic composition are added to the spray, toner and cream respectively to form soothing and anti-allergic skin care products, wherein the spray, toner and cream basic formula used in the soothing and anti-allergic skin care product do not contain soothing and anti-allergic ingredients. The soothing and anti-allergic composition in the present application can be used alone or added to any skin care product. The different dosage form skin care product basic formula used in the following examples is only a specific example provided for convenience and does not mean that the soothing and anti-allergic composition in the present application can only be added to the skin care product basic formula of the following formula. The specific implementation of the present application is further described in detail in combination with specific examples:

[0033] Spray examples 1-10

[0034] The components of the soothing and anti-allergic spray in spray examples 1-10 include the spray basic formula and the soothing and anti-allergic composition, wherein the components of the spray basic formula and the content of each component are shown in the spray basic formula in Table 1, and the components in the soothing and anti-allergic composition and the addition ratio of each component in the soothing and anti-allergic spray are shown in Table 2.

[0035] The soothing and anti-allergic spray in spray examples 1-10 is prepared by the following preparation method, specifically including the following steps:

[0036] 1) Heat water, butylene glycol, p-hydroxyacetophenone and 1,2-hexanediol to 60℃, dissolve completely, and reserve;

[0037] 2) Cool to about 37℃, add false octagonal leaf extract, hydrolyzed algal extract, sea salt and polysaccharide to the pot, stir until uniform, cool to room temperature, sample detection, qualified discharge, and prepare the soothing and anti-allergic spray.

[0038] Toner examples 1-10

[0039] The components of the soothing and anti-allergic toner in toner examples 1-10 include the toner basic formula and the soothing and anti-allergic composition, wherein the components of the toner basic formula and the content of each component are shown in the toner basic formula in Table 1, and the components in the soothing and anti-allergic composition and the addition ratio of each component in the soothing and anti-allergic toner are shown in Table 2.

[0040] The soothing and anti-allergic toner in toner examples 1-10 is prepared by the following preparation method, specifically including the following steps:

[0041] 1) Pre-treatment phase: butanediol, p-hydroxyacetophenone, 1,2-hexanediol heated to 60°C, completely dissolved, ready for use;

[0042] 2) Water, glycerin, gum arabic, xanthan gum were added to the stirring pot, heated to 80°C and stirred until completely dissolved;

[0043] 4) The homogenization emulsification in the stirring pot was started, the stirring speed was 2500-3000 r / min, the homogenization emulsification time was 5-10 min, vacuum defoaming, and cooled to 60°C, then the pre-treatment phase was added and ready for use;

[0044] 5) Cooled to about 37°C, the Illicium lanceolatum leaf extract, hydrolyzed algae extract, sea salt and polysaccharide were added to the pot, stirred until uniform, cooled to room temperature, sampled and tested, qualified discharge, and the soothing and anti-allergic skin toner was prepared.

[0045] Cream examples 1-10

[0046] The components of the soothing and anti-allergic cream in cream examples 1-10 include a cream base formula and a soothing and anti-allergic composition, wherein the components of the cream base formula and the content of each component are shown in Table 1, and the components in the soothing and anti-allergic composition and the addition ratio of each component in the soothing and anti-allergic cream are shown in Table 2.

[0047] The soothing and anti-allergic cream in cream examples 1-10 was prepared by the following method, specifically including the following steps:

[0048] 1) Pre-treatment phase: p-hydroxyacetophenone, 1,2-hexanediol heated to 60°C, completely dissolved, ready for use;

[0049] 2) Water, glycerin, cellulose, xanthan gum, acryloyldimethyltaurine ammonium / VP copolymer were added to the stirring pot, heated to 80°C and stirred until completely dissolved;

[0050] 3) Hydrogenated lecithin, MONTANOV L, Edenor C18-65 MY, dimethicone, squalane, cetyl alcohol ethylhexanoate, glyceryl tri(ethylhexanoate), tocopheryl acetate were added to the oil pot, heated to 80°C until completely dissolved;

[0051] 4) The material in the oil pot was pumped into the stirring pot, the homogenization emulsification was started, the stirring speed was 2500-3000 r / min, the homogenization emulsification time was 5-10 min, vacuum defoaming, and cooled to 60°C, then the pre-treatment phase was added and ready for use;

[0052] 5) Cooled to about 37°C, the Illicium lanceolatum leaf extract, hydrolyzed algae extract, sea salt and polysaccharide were added to the pot, stirred until uniform, cooled to room temperature, sampled and tested, qualified discharge, and the soothing and anti-allergic cream was prepared.

[0053] Table 1 Spray, Toner, Cream Base Formulation

[0054]

[0055]

[0056] Table 2 Composition and Addition Ratio of Soothing Anti-Sensitive Composition

[0057]

[0058] Comparative Examples 1-21

[0059] Comparative Example 1

[0060] The spray in this example differs from Spray Example 1 in that it does not contain Illicium lanceolatum leaf extract; the other components and their proportions are the same as in Spray Example 1.

[0061] Comparative Example 2

[0062] The spray in this example differs from Spray Example 1 in that it does not contain hydrolyzed algae extract; the other components and their proportions are the same as in Spray Example 1.

[0063] Comparative Example 3

[0064] The spray in this example differs from Spray Example 1 in that it does not contain beta-glucan; the other components and their proportions are the same as in Spray Example 1.

[0065] Comparative Example 4

[0066] The spray in this example differs from Spray Example 1 in that it does not contain sea salt; the other components and their proportions are the same as in Spray Example 1.

[0067] Comparative Example 5

[0068] The spray in this example differs from Spray Example 1 in that sea salt is replaced by an equivalent amount of refined salt; the other components and their proportions are the same as in Spray Example 1.

[0069] Comparative Example 6

[0070] This example uses the spray base formulation in Table 1. This example does not contain Illicium lanceolatum leaf extract, hydrolyzed algae extract, sea salt, and polysaccharide.

[0071] Comparative Example 7

[0072] The toner in this example differs from Toner Example 7 in that it does not contain Illicium lanceolatum leaf extract; the other components and their proportions are the same as in Toner Example 7.

[0073] Comparative Example 8

[0074] The toner in this example differs from the toner of Example 7 in that it does not contain hydrolyzed algae extract, and the other components and their proportions are the same as in the toner of Example 7.

[0075] Comparative Example 9

[0076] The toner in this example differs from the toner of Example 7 in that it does not contain beta-glucan, and the other components and their proportions are the same as in the toner of Example 7.

[0077] Comparative Example 10

[0078] This example includes toner Comparative Example 10, cream Comparative Example 10; wherein toner Comparative Example 10 differs from the toner of Example 7 in that it does not contain sea salt, and the other components and their proportions are the same as in the toner of Example 7. Cream Comparative Example 10 differs from the cream of Example 7 in that it does not contain sea salt, and the other components and their proportions are the same as in the cream of Example 7.

[0079] Comparative Example 11

[0080] The toner in this example differs from the toner of Example 7 in that it does not contain Illicium lanceolatum leaf extract and hydrolyzed algae extract, and the other components and their proportions are the same as in the toner of Example 7.

[0081] Comparative Example 12

[0082] The toner in this example differs from the toner of Example 7 in that it does not contain Illicium lanceolatum leaf extract and beta-glucan, and the other components and their proportions are the same as in the toner of Example 7.

[0083] Comparative Example 13

[0084] The toner in this example differs from the toner of Example 7 in that it does not contain hydrolyzed algae extract and beta-glucan, and the other components and their proportions are the same as in the toner of Example 7.

[0085] Comparative Example 14

[0086] This example includes toner Comparative Example 14, cream Comparative Example 14; wherein toner Comparative Example 14 differs from the toner of Example 7 in that it does not contain sea salt and hydrolyzed algae extract, and the other components and their proportions are the same as in the toner of Example 7. Cream Comparative Example 14 differs from the cream of Example 7 in that it does not contain sea salt and hydrolyzed algae extract, and the other components and their proportions are the same as in the cream of Example 7.

[0087] Comparative Example 15

[0088] The example includes lotion comparative example 15, cream comparative example 15; wherein the lotion comparative example 15 is different from the lotion example 7 in that it does not contain Illicium anisatum leaf extract and sea salt, and the rest of the components and the amount ratio are the same as the lotion example 7. The cream comparative example 15 is different from the cream example 7 in that it does not contain Illicium anisatum leaf extract and sea salt, and the rest of the components and the amount ratio are the same as the cream example 7.

[0089] Comparative example 16

[0090] The example includes lotion comparative example 16, cream comparative example 16; wherein the lotion comparative example 16 is different from the lotion example 7 in that it does not contain sea salt and beta-glucan, and the rest of the components and the amount ratio are the same as the lotion example 7. The cream comparative example 16 is different from the cream example 7 in that it does not contain sea salt and beta-glucan, and the rest of the components and the amount ratio are the same as the cream example 7.

[0091] Comparative example 17

[0092] The lotion in the example is different from the lotion example 7 in that it does not contain Illicium anisatum leaf extract, hydrolyzed algae extract and beta-glucan, and the rest of the components and the amount ratio are the same as the lotion example 7.

[0093] Comparative example 18

[0094] The example includes lotion comparative example 18, cream comparative example 18; wherein the lotion comparative example 18 is different from the lotion example 7 in that it does not contain sea salt, beta-glucan and Illicium anisatum leaf extract, and the rest of the components and the amount ratio are the same as the lotion example 7. The cream comparative example 18 is different from the cream example 7 in that it does not contain sea salt, beta-glucan and Illicium anisatum leaf extract, and the rest of the components and the amount ratio are the same as the cream example 7.

[0095] Comparative example 19

[0096] The example includes lotion comparative example 19, cream comparative example 19; wherein the lotion comparative example 19 is different from the lotion example 7 in that it does not contain sea salt, beta-glucan and hydrolyzed algae extract, and the rest of the components and the amount ratio are the same as the lotion example 7. The cream comparative example 19 is different from the cream example 7 in that it does not contain sea salt, beta-glucan and hydrolyzed algae extract, and the rest of the components and the amount ratio are the same as the cream example 7.

[0097] Comparative example 20

[0098] This example includes lotion comparative example 20, cream comparative example 20; wherein lotion comparative example 20 is different from lotion example 7 in that it does not contain sea salt, Illicium lanceolatum leaf extract and hydrolyzed algae extract, and the rest of the components and the amount ratio are the same as lotion example 7. Cream comparative example 20 is different from cream example 7 in that it does not contain sea salt, Illicium lanceolatum leaf extract and hydrolyzed algae extract, and the rest of the components and the amount ratio are the same as cream example 7.

[0099] Comparative example 21

[0100] This example includes lotion comparative example 21, cream comparative example 21; wherein lotion comparative example 21 uses the lotion base formula in Table 1, and does not contain Illicium lanceolatum leaf extract, hydrolyzed algae extract, sea salt and polysaccharide. Cream comparative example 21 uses the cream base formula in Table 1, and does not contain Illicium lanceolatum leaf extract, hydrolyzed algae extract, sea salt and polysaccharide.

[0101] Performance test:

[0102] Experiment 1: Redness subsidence experiment of capsaicin stimulation model

[0103] Three volunteers were selected, and three 3cm x 5cm areas on the inner forearm of each volunteer were selected as blank areas, comparative example 6 treated areas and example 1 treated areas respectively. Each area was pasted with a patch containing 0.005% capsaicin solution to stimulate redness, and then the corresponding sample was applied according to the random table, and the TiVi 700 was used to take pictures to analyze the redness subsidence at 0min, 10min, 30min, 60min and 120min after application. The plot of skin blood cell concentration change value versus time is shown in Figure 1 .

[0104] As can be seen from Figure 1 , after pasting capsaicin, the skin blood cell concentration change value of the blank area, the comparative example 6 treated area and the example 1 treated area will peak at about 30min, and then gradually decrease. This is a phenomenon caused by normal stress and metabolic response of the skin, and it is obvious that the peak value of the blank area is the highest, and after using the spray in comparative example 6, the peak value decreases slightly, and after using the spray in example 1, the peak value has a large amplitude of reduction, indicating that the soothing and anti-sensitivity spray in example 1 has good soothing and anti-sensitivity effect.

[0105] According to the experimental results, 21 volunteers were selected, three people in each group, and each group of volunteers was applied with capsaicin. Then, the sprays prepared in Examples 1-2 and Comparative Examples 1-5 were sprayed on the treated areas, respectively. After 30 minutes, TiVi700 was used to take pictures to analyze the red spot subsidence, and the volunteers' sensory feedback was collected to evaluate the burning and stinging sensation, which was scored from 1 to 10. The higher the score, the stronger the burning and stinging sensation. The average values of the skin blood cell concentration and sensory evaluation of each group of personnel obtained by testing are shown in Table 3.

[0106] Table 3 Skin blood cell concentration and sensory evaluation results after treatment with the sprays in Examples 1-2 and Comparative Examples 1-5

[0107] Index Skin blood cell concentration value Burning sensation Pricking sensation Example 1 10.7 1.0 1.3 Example 2 11.0 1.0 1.0 Comparative Example 1 16.3 4.8 4.7 Comparative Example 2 15.7 4.9 4.6 Comparative Example 3 16.0 5.7 5.2 Comparative Example 4 18.3 7.3 7.6 Comparative Example 5 18.0 7.6 8.0 Comparative Example 6 22.0 9.0 9.3 Blank area 25.0 10.0 10.0

[0108] As can be seen from Table 3, the sprays in Examples 1-2 can significantly reduce the skin blood cell concentration value caused by capsaicin and weaken the burning and stinging sensation. According to the test results of Comparative Examples 1-4, it can be known that in the soothing and anti-allergic composition of the present application, the effect will be weakened if any component is reduced. In contrast, reducing sea salt will significantly weaken the soothing effect, and compared with Comparative Example 5, the sea salt in Example 1 is replaced by salt, and the blood cell concentration value of the volunteers is not much different from the effect of removing sea salt in Comparative Example 4, indicating that sea salt has a technical effect that cannot be replaced by salt, and salt may increase the stinging sensation of volunteers. Therefore, it can be known that sea salt can greatly improve the soothing effect of the soothing and anti-allergic composition in the present application.

[0109] Experiment 2: Sensitivity index evaluation test

[0110] In order to further illustrate the synergistic effect between sea salt, false octagonal leaf extract, β-glucan and hydrolyzed algal extract, the present application selected 23 volunteers with sensitive skin to use the toners in Examples 3-10 and Comparative Examples 7-21. Each volunteer used one toner, and the subjects used it once a day for two weeks according to the product usage method. The skin condition after using the sample was evaluated through a questionnaire to analyze the product usage effect. The dimensions of the sensitivity index collected included stinging phenomenon, burning phenomenon, itching phenomenon, tightness phenomenon and redness phenomenon. Among them, the usage effect of each product was evaluated by scoring, and the score of each dimension was 1-10. The higher the average score of the five dimensions, the higher the sensitivity. The sensitivity index scores before use, one week after use and two weeks after use were counted, and the sensitivity index change rates were calculated, wherein, change rate 1% = (A 使用前 -A 使用一周后 ) / A 使用前 ; change rate 2% = (A 使用前 -A 使用二周后 ) / A 使用前 , A使用前 , A 使用一周后 , A 使用二周后 respectively are the sensitive index scores before use, after one week of use, and after two weeks of use; the specific test results are shown in Table 4.

[0111] Table 4 results of sensitive index change analysis

[0112]

[0113]

[0114] As can be seen from Table 4, the soothing and anti-sensitivity compositions of Examples 3-10 have a clear dose-effect relationship, but when the content of each component in the soothing and anti-sensitivity composition reaches a certain concentration, further increasing the content of the components does not significantly change the soothing effect. Comparative Examples 7-20 have a relatively obvious soothing effect compared to Comparative Example 21. Compared to Example 7, Comparative Example 10 lacks sea salt, Comparative Examples 14-16 lack one of sea salt and one of the three components of Illicium lanceolatum leaf extract, hydrolyzed algal extract, and β-glucan, and Comparative Examples 18-20 lack two of sea salt and the three components of Illicium lanceolatum leaf extract, hydrolyzed algal extract, and β-glucan, and the soothing effect is obviously reduced, thereby indicating that the components in the soothing and anti-sensitivity composition of the present application and between sea salt and other components have a significant synergistic effect. In addition, Comparative Examples 16, 18, and 19 lack polysaccharides in addition to sea salt, and comparison shows that sea salt and polysaccharides also have a certain synergistic effect.

[0115] Experiment 3: Stratum corneum water content, skin water loss amount, and overall soothing effect test

[0116] Eighteen volunteers were selected to use the cream in Example 7 and the creams in Comparative Examples 10, 14-16, and 18-21, respectively. Each subject used one cream, and the subjects used the product once in the morning and once in the evening every day. Before use and 7 days after use, under the conditions of a temperature of 21±1℃ and a humidity of 50±10%, the subjects cleaned their faces and waited for 20 min before measuring the water content of the face and the trans-epidermal water loss (TEWL value) to comprehensively evaluate the repair effect of the product on human skin. The experimental results are shown in Table 5, wherein the water content change rate refers to the change rate of the skin water content after using the product compared to before use. A positive value indicates an increase in water content and an increase in skin moisture, and a negative value indicates a decrease in water content and a decrease in skin moisture. The TEWL value change rate refers to the change rate of the skin water loss rate after using the product compared to before use. A negative value indicates a decrease in the skin water loss rate and an increase in the skin barrier function, and a positive value indicates an increase in the skin water loss rate and a decrease in the skin barrier function.

[0117] Table 5 test results of stratum corneum water content and skin water loss amount

[0118]

[0119]

[0120] From Table 5, it can be seen that the cream in Example 7 can significantly increase the water content in the stratum corneum and significantly reduce the amount of skin water loss, compared with the creams in Comparative Examples 10, 14-16 and 18-21, further indicating that the sea salt has a significant synergistic effect with other components in the soothing and anti-irritation composition.

[0121] In addition, 32 volunteers were selected as subjects, and each of the 32 subjects received the cream sample prepared in Example 7 and was required to use it once on the same day and three times within seven days. After the subjects used the product as required, the skin condition after using the sample was evaluated by a questionnaire to analyze the use effect of the product. The experimental results are shown in Table 6, wherein an effective rate ≥ 50% can be considered as an effective product, and the effective rate = (obviously + very obviously) / total number of people.

[0122] Table 6 Test results of the soothing and anti-irritation cream prepared in Example 7

[0123] Index Not very noticeable Not noticeable Noticeable Very noticeable Efficiency (noticeable + very noticeable) Improvement in skin dryness 0 2 16 14 93.75％ Improvement in irritation and the like 0 6 19 7 81.25％ Improvement in skin tautness 0 5 16 11 81.38％ Improvement in redness 0 10 18 14 68.75％ Overall evaluation of soothing effect 0 5 20 7 84.38％

[0124] From Table 6, it can be seen that the soothing and anti-irritation cream prepared in Example 7 can effectively improve the phenomena of dry skin, irritation, skin tightness, skin redness and the like, and the total effective rate of the soothing effect is 84.38%, further indicating that the soothing and anti-irritation composition in the present application has a good soothing and anti-irritation effect. It can be seen from the self-evaluation of the subjects in Table 6 and the test results of the water content in the stratum corneum and the amount of skin water loss in Table 5 that the results of the instrument test and the consumer self-evaluation are basically consistent.

[0125] The above embodiments of the present application are described in detail, but the present application is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the spirit of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. A soothing and anti-allergic composition, characterized in that: It is composed of the following components in parts by weight: sea salt 0.001-5.0 parts; hydrolyzed algae extract 0.001-3.0 parts; false star anise leaf extract 0.001-5.0 parts; polysaccharide 0.001-1.0 parts; The polysaccharide is selected from at least one of Schizophyllum commune polysaccharide and β-glucan; The sea salt contains the following components: sodium ions, calcium ions, magnesium oxide, and sulfate ions.

2. The soothing and anti-allergic composition according to claim 1, characterized in that: It includes the following components in parts by weight: 0.001-1.0 parts sea salt; 0.01-1.0 parts hydrolyzed algae extract; 0.01-3.0 parts false star anise leaf extract; and 0.005-0.5 parts polysaccharide.

3. The method for preparing the soothing and anti-allergic composition according to any one of claims 1 to 2, characterized in that: Includes the following steps: The components are mixed to obtain the soothing and anti-allergic composition.

4. A soothing and anti-allergic skincare product, characterized in that: Includes the soothing and anti-allergic composition according to any one of claims 1 to 2.

5. The skincare product according to claim 4, characterized in that: In the skin care product, the soothing and anti-allergic composition has a mass percentage of 0.004-14%.

6. The skincare product according to claim 4, characterized in that: In the skin care product, the soothing and anti-allergic composition has a mass percentage of 0.026~5.5%.

7. The skincare product according to claim 4, characterized in that: The skincare products include sprays, toners, serums, lotions, creams, or masks.

8. The use of the soothing and anti-allergic composition according to any one of claims 1 to 2 in the field of cosmetic preparation.

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