A Chinese medicine composition for treating rheumatoid arthritis and sarcopenia, and its preparation method and application

Abstract

The present invention belongs to the field of medicine, and specifically relates to a Chinese medicine composition for treating rheumatoid arthritis sarcopenia, and a preparation method and application thereof. The composition is composed of: 9-60g of raw astragalus, 9-15g of peony, 9-30g of cinnamon twig, 15-30g of stir-fried atractylodes, 9-30g of angelica, 9-15g of notopterygium, 9-15g of siler, 9-30g of swollen joint herb, 6-12g of scutellaria baicalensis, and 3-6g of roasted liquorice. The beneficial effects of the present invention are: invigorating qi and blood, regulating liver and spleen, dispelling wind and dampness, and relieving arthritis and promoting tissue regeneration. It is used for rheumatoid arthritis sarcopenia caused by deficiency of Yingwei Qi and blood, liver and spleen disorders, internal invasion of external evils such as wind, cold and dampness, stagnation of Qi and blood, and lack of nourishment of tendons and muscles. The following symptoms can be seen: weakness or paralysis of limb muscles, swollen and painful joints, soreness or migratory pain, heaviness or numbness of joint muscles, spasm, morning stiffness, fatigue, poor appetite, pale tongue with thin coating, fat tongue or tongue with teeth marks, and stringy or thin pulse.

Description

Technical Field

[0001] The present invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for treating rheumatoid arthritis sarcopenia, and a preparation method and application thereof. Background Art

[0002] Rheumatoid arthritis (RA) is a common and intractable autoimmune disease with the characteristics of complex mechanism, easy relapse, ultimate disability and many complications. The incidence of RA complicated with sarcopenia (sarcopenia in rheumatoid arthritis) is as high as about 31%. It can appear in the early stage of RA, involving skeletal muscles throughout the body, and is progressive. It is mainly manifested as insufficient muscle strength and decreased muscle quality. It is a precursor risk factor for RA bone destruction, which can accelerate the patient's physical disability, increase the risk of death, seriously affect the patient's limb function and quality of life, and bring a huge burden to society and family. Rheumatoid arthritis sarcopenia belongs to the category of "biwei" in traditional Chinese medicine. At present, conventional treatment drugs for RA, such as glucocorticoids, traditional DMARDs, biological agents and JAK inhibitors, can control RA inflammation and bone destruction, but it is difficult to restore skeletal muscle quality and function. There is currently no effective treatment for it. Summary of the invention

[0003] In view of the problems existing in the prior art, the present invention provides a traditional Chinese medicine composition for treating rheumatoid arthritis sarcopenia.

[0004] The present invention also provides a method for preparing a traditional Chinese medicine composition for treating rheumatoid arthritis sarcopenia.

[0005] Another object of the present invention is to provide the use of the above-mentioned Chinese medicine composition in the preparation of a drug for treating rheumatoid arthritis sarcopenia.

[0006] The technical solution adopted by the present invention to achieve the above-mentioned purpose is:

[0007] The present invention provides a Chinese medicine composition for treating rheumatoid arthritis sarcopenia, the raw materials comprising, by weight:

[0008] Raw Astragalus 9-60g, Peony 9-15g, Cassia twig 9-30g, stir-fried Atractylodes 15-30g, Angelica 9-30g, Notopterygium 9-15g, Saposhnikovia 9-15g, Sarcandra 9-30g, Caulis Sinomenii 6-12g, and roasted Licorice root 3-6g.

[0009] Furthermore, in the Chinese medicine composition provided by the present invention, the raw materials also include: 15-30g of Codonopsis pilosula and 15-30g of Poria cocos.

[0010] Further, the raw material medicine also includes: 9g-12g of Xu Changqing, 10g-30g of Piper mesenteriae; or, the raw material medicine also includes: 15g of Angelica dahurica, 15g of Polygonum cuspidatum, 15g of Papaya; or, the raw material medicine also includes: 9g of Aconitum carmichaelii, 15g of Salt Eucommia ulmoides, 6g of Cinnamon bark; or, the raw material medicine also includes 30g of Rehmannia root and 15g of Cornus officinalis.

[0011] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps: accurately weighing according to the formula, adding 250 ml of water, first decocting for 40 minutes, second decocting for 25 minutes, filtering the residue while hot, and mixing the two decoctions and concentrating them into 200 ml.

[0012] The present invention also provides a use of the traditional Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicament for treating rheumatoid arthritis sarcopenia.

[0013] Treatment principle: tonify Qi and harmonize blood, regulate the liver and spleen, dispel wind and dampness, relieve numbness and promote tissue regeneration.

[0014] Prescription modification: If fatigue, tiredness, laziness, poor appetite, loose stools, add Codonopsis pilosula 15g, Poria 15g; if there is migratory joint pain, add Cynanchum paniculatum 12g, Piper mesenteriae 12g; if the lower limb joints are swollen and painful, and the joints and muscles are heavy, add Angelica dahurica 15g, Polygonum cuspidatum 15g, and Papaya 15g; if there are symptoms of Yang deficiency such as fear of cold, cold limbs, etc., add Radix Aconiti Lateralis Preparata 9g 先煎 , salt-soaked Eucommia 15g, cinnamon 6g; if dizziness, tinnitus, low back pain and fatigue occur, add Rehmannia root 30g, wine-soaked Cornus fruit 15g.

[0015] The invention has the beneficial effects of invigorating qi and blood, regulating the liver and spleen, dispelling wind and dampness, relieving numbness and promoting muscle growth. It is used for rheumatoid arthritis sarcopenia caused by deficiency of Yingwei qi and blood, liver and spleen disorders, invasion of wind, cold and dampness and other external evils, stagnation of qi and blood, and lack of nourishment of tendons and muscles, with the following symptoms: weakness or paralysis of limb muscles, swelling and pain in joints, soreness or migratory pain, heaviness or numbness of joint muscles, morning stiffness, fatigue, poor appetite, pale tongue with thin coating, fat tongue or with tooth marks, and stringy or stringy pulse. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a comparison of joints between the animal model group and the experimental group;

[0017] Figure 2 Comparison of Oil Red O staining of gastrocnemius muscle between the experimental group and the model group; Note: Orange or red represents lipid;

[0018] Figure 3 Comparison of HE staining of gastrocnemius muscle between the experimental group and the model group. DETAILED DESCRIPTION

[0019] The technical solution of the present invention is further explained and illustrated by means of specific embodiments below.

[0020] Example 1

[0021] The recipe is: raw astragalus 9-60g, peony 9-15g, cinnamon twig 9-30g, stir-fried atractylodes 15-30g, angelica 9-30g, notopterygium wilfordii 9-15g, siler 9-15g, swollen knotweed 9-30g, green wind vine 6-12g, and roasted licorice 3-6g.

[0022] Effect Example

[0023] 1. Clinical trial data

[0024] 1. Data Source

[0025] A total of 60 patients with RA sarcopenia who met the criteria and were admitted to the Department of Rheumatology and Immunology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine from December 2021 to March 2023 were included.

[0026] 2. Grouping and treatment plan

[0027] According to the random number table method, the patients were divided into an experimental group (30 cases) and a control group (30 cases). Both groups received methotrexate (10 mg qw) and folic acid (5 mg qw) treatment. The experimental group was given the patented prescription with additions and subtractions on this basis. The treatment course was 12 weeks.

[0028] 3. Observation indicators

[0029] The TCM symptom scores, disease activity scores of 28 joints (DAS28), and skeletal muscle mass index (SMI) (skeletal muscle mass of limbs / height) of the two groups were observed before and after treatment. 2 ), muscle strength (grip strength), physical function index (6-meter gait speed), muscle activity function (Simple Physical Status Scale SPPB), BMI, calf circumference, triceps skinfold thickness (TSF), upper arm muscle circumference (AMC), serum prealbumin (PA), serum albumin (ALB), inflammatory indexes (ESR, CRP) were used to evaluate the clinical efficacy.

[0030] 4. Statistical results

[0031] The results showed that the total effective rate of the experimental group was 87.1%, which was higher than 63.3% in the control group (P<0.05). Compared with before treatment, the symptom scores of joint pain / pain, fatigue, palpitations, shortness of breath, dizziness, and poor appetite in both groups were reduced after treatment, and the difference was statistically significant (P<0.05). Among them, the symptom scores of joint pain / pain (0.74±0.58 points, 1.07±0.64 points, P<0.05), fatigue (0.61±0.56 points, 1.20±0.55 points, P<0.01), and poor appetite (0.71±0.53 points, 1.17±0.59 points, P<0.05) in the experimental group were lower than those in the control group after treatment, with statistical differences.

[0032] Table 1 Comparison of TCM symptom scores between the two groups before and after treatment

[0033]

[0034] Note: * Represents the comparison before and after treatment within the group, P<0.05, & Represents the comparison between groups after treatment, P<0.05.

[0035] The DSA28 scores of the two groups decreased significantly before and after treatment (P < 0.01), and the decrease in the experimental group was greater than that in the control group (P < 0.05). In terms of skeletal muscle function, the SMI (4.98 ± 0.60 kg / m 2 , 7.21±0.47kg / m 2 , P<0.05), grip strength (14.38±6.17kg, 17.06±4.11kg, P<0.01), 6-meter gait speed (0.75±0.09m / s, 0.90±0.16m / s, P<0.01), SPPB score (6.32±2.11, 9.18±1.52, P<0.05) all increased, and the difference was statistically significant, while the control group had no statistically significant difference in these four indicators before and after treatment. After treatment, the experimental group was better than the control group in SMI, grip strength, 6-meter gait speed, SPPB score, etc., and the difference was statistically significant.

[0036] Table 2 Comparison of DAS28 scores and skeletal muscle function-related indicators between the two groups before and after treatment

[0037]

[0038] Note: * Represents the comparison after treatment within the group, P<0.05, & The data represent the comparison between the groups before and after treatment, P<0.05.

[0039] In the experimental group, BMI (19.23±2.14, 21.42±2.32, P<0.05), calf circumference (28.68±3.10cm, 32.41±3.17cm, P<0.05), TSF (8.42±1.57mm, 11.02±1.42mm, P<0.05), AMC (16.62±2.65mm, 20.49±2.36mm, P<0.05), PA (190.28±20.34mg / L, 210.55±19.22mg / L, P<0.05), ALB (31.28±5.34, 35.47±5.63, P<0.05) were improved before and after treatment, and the differences were statistically significant. However, there were no statistical differences in the control group before and after treatment in these six items.

[0040] Table 3 Comparison of BMI, calf circumference, TSF, AMC, PA, ALB related indicators between the two groups before and after treatment

[0041]

[0042] Note: * Represents intra-group comparison after treatment, P<0.05.

[0043] Compared with the control group before and after treatment, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in the experimental group were significantly reduced (P<0.05), with statistically significant differences. Compared with the control group after treatment, the C-reactive protein in the experimental group (5.40±3.00mg / L, 7.72±4.45mg / L, P<0.05) was significantly reduced, with statistically significant differences.

[0044] Table 4 Comparison of ESR and CRP indexes before and after treatment between the two groups

[0045]

[0046] Note: & Represents the comparison after treatment within the group, P<0.05, * The data represent the comparison between the groups before and after treatment, P<0.05.

[0047] (II) Basic Experiments

[0048] 1. Experimental methods and results

[0049] Male Wistar rats were randomly divided into 4 groups: blank group (n=10), model group (n=10), methotrexate group (n=10) and experimental group (patented prescription for RA sarcopenia group: raw astragalus 9g, peony 9g, cinnamon twig 9g, stir-fried atractylodes 15g, angelica 9g, notopterygium 9g, siler 9g, swollen knotweed 9g, scutellaria baicalensis 6g, and licorice 3g, n=10). Drug intervention was used 21 days after CIA induction: methotrexate group was given 0.7 mg / kg once a week; experimental group was given 4.725 g / kg once a day; blank group and model group were gavaged with equal amount of normal saline. The rats were killed 4 weeks after gavage. Gastrocnemius, quadriceps femoris, soleus, and tibialis anterior muscles were separated and weighed for wet weight; gastrocnemius was pathologically sectioned and stained with HE and Oil Red O.

[0050] The results show that:

[0051] (1) Comparison of skeletal muscle mass: Compared with the blank group, the mass of the gastrocnemius, quadriceps, soleus, and tibialis anterior muscles in the model group decreased (43%, 41%, 30%, and 31%, respectively), indicating that the model was successfully established. Compared with the model group, the mass of the quadriceps in the methotrexate group increased (29%, P < 0.05), and the mass of the other muscles did not change significantly; the mass of the gastrocnemius, quadriceps, and soleus in the experimental group increased (34%, 32%, and 23%, respectively, P < 0.05). Figure 1 shown.

[0052] (2) Gastrocnemius muscle pathological sections (HE staining): The cross-sectional area of ​​muscle fibers in the experimental group was significantly increased compared with that in the model group. Figure 3 As shown; Oil red O staining showed that fat infiltration in skeletal muscle of the experimental group was significantly reduced, as shown Figure 2 shown.

[0053] (III) Treatment cases

[0054] Treatment Case 1

[0055] Patient information: Zhang, female, 39 years old, has had multiple joint pain and swelling for 3 years, which has worsened with fatigue and muscle loss for more than 2 months. She was treated in a certain hospital 3 years ago, and the RF was 231IU / ml, anti-CCP antibody>1600RU / ml, and erythrocyte sedimentation rate was 45mm / hr. She was diagnosed with "rheumatoid arthritis". She took Chinese and Western medicines such as methotrexate, leflunomide, and aceclofenac enteric-coated capsules. The symptoms recurred and her condition was unstable. Symptoms at the time of consultation: swelling and pain in the proximal interphalangeal joints of both hands, swelling and pain in both knees, pain in the right elbow joint, and limited flexion and extension. She was sore and weak all over, thin body, thin muscles, fear of cold, fatigue, poor appetite, occasional dizziness, pale tongue, thin white fur, and thin pulse. Laboratory examination and scoring: DSA28 score was 5.6 points, VAS score was 8 points, ESR: 37mm / hr, CRP: 21.4mg / L; body composition analysis showed: BMI = 17.70, limb skeletal muscle mass = 13.01kg, SMI = 4.96kg / m 2 ; Maximum grip strength (12.3kg). Diagnosis: Rheumatoid arthritis and sarcopenia.

[0056] Prescription: 30g raw Astragalus, 12g peony, 15g cinnamon twig, 15g stir-fried Atractylodes, 15g angelica, 6g roasted Licorice, 9g Notopterygium, 9g Saposhnikovia, 30g Sarcandra, 12g Caulis Sinomenii, 15g Codonopsis, and 15g Poria.

[0057] Dosage and administration: 14 doses, decocted in ordinary water. Accurately weigh according to the formula, add 250 ml of water, boil for 40 minutes for the first decoction, and 25 minutes for the second decoction. Filter the residue while hot, mix the two decoctions and concentrate to 200 ml, take twice a day, one dose per day.

[0058] Effect: After taking it for 14 days, the joint swelling and pain were significantly relieved, the elbow joint activity improved, the fatigue was relieved, and the appetite was better than before. After the symptoms improved, the above treatment was mainly added or subtracted. After the symptoms were relieved, it was changed to one dose every other day. After taking it regularly for 6 months, there was no obvious swelling and pain in the joints, the energy improved, the appetite was normal, the complexion turned rosy, and the weight increased by 2 kg. At the follow-up visit, the DSA28 score dropped to 2.4 points, the VAS score was 1 point, ESR: 15mm / h, CRP: 7.83mg / L; body composition analysis showed: BMI=19.23, SMI=5.62kg / m2; maximum grip strength (15.3kg).

[0059] Treatment Case 2

[0060] Patient information: Cai, female, 44 years old, had migratory pain in the right wrist, elbow and knee joints for 6 years, accompanied by soreness and weakness in both lower limbs for more than 2 months. She was diagnosed with "rheumatoid arthritis" at a local hospital, and the intermittent self-application of plasters and oral medications were ineffective. Symptoms at the time of consultation: slight swelling of the right wrist, elbow and knee joints, obvious pain, and migratory pain. Muscle soreness and weakness in both lower limbs, poor lower limb strength, thin body, fear of wind and cold, shortness of breath and fatigue, poor appetite and sleep, normal bowel movements, pale tongue, thin white fur, teeth marks on the edges, and thin pulse. Laboratory tests and scores: DSA28 score of 6.1 points, VAS score of 8 points, ESR (48mm / hr), CRP (27.42mg / L); body composition analysis showed: BMI = 18.30, skeletal muscle content of limbs = 13.39kg, SMI = 4.89kg / m 2 ; Maximum grip strength (14.2kg). Diagnosis: Rheumatoid arthritis and sarcopenia.

[0061] Prescription: 30g raw Astragalus, 12g peony, 15g cinnamon twig, 18g stir-fried Atractylodes, 12g angelica, 6g roasted Licorice, 15g Notopterygium, 12g Saposhnikovia, 30g Sarcandra, 9g Caulis Sinomenii, 12g Cynanchum wilfordii, 18g Caulis Piperis.

[0062] Dosage and administration: 14 doses, decocted in ordinary water, accurately weigh according to the formula, add 250 ml of water, boil for 40 minutes for the first decoction and 25 minutes for the second decoction, filter the residue while hot, mix the two decoctions and concentrate to 200 ml, take warm in two times, one dose per day.

[0063] Effect: After taking it for 14 days, the joint pain was relieved, the soreness of both lower limbs was relieved, the strength was slightly improved, and the appetite was significantly improved. The above-mentioned prescription was used as the main treatment with additions and subtractions. After taking it regularly for 8 months, there was no shortness of breath and fatigue, no obvious pain in the joints, fear of wind and cold disappeared, and the strength of the lower limbs was significantly improved. At the second visit, the DSA28 score dropped to 2.5 points, the VAS score was 1 point, the ESR: 15mm / h, the CRP: 6.31mg / L; body composition analysis showed: BMI = 19.21, SMI = 6.01kg / m2; maximum grip strength (15.2kg).

[0064] Treatment Case 3

[0065] Patient information: Chang, male, 57 years old, has had swelling and pain in both knees and ankles for 7 years, which has worsened with heaviness and weakness of lower limb muscles for more than 2 months. The patient had swelling and pain in the interphalangeal joints of both hands 7 years ago. He was diagnosed with "rheumatoid arthritis" at the local hospital. RF: 589IU / ml, anti-CCP antibody>1600RU / ml, erythrocyte sedimentation rate: 45mm / hr. He was diagnosed with "rheumatoid arthritis" and took methotrexate, tripterygium wilfordii tablets, aceclofenac acid enteric-coated capsules and other Chinese and Western medicines. The symptoms recurred and the condition was unstable. The effect of local physical therapy was not obvious. Symptoms at the time of consultation: obvious swelling and pain in both ankles and knees, deformity of the right knee joint, limited flexion and extension of the knee joint, and limited flexion, abduction and external rotation of the ankle joint. Obvious general fatigue, thin body, heaviness and discomfort of the lower limb muscles, poor appetite, occasional dizziness, pale tongue, thin white fur, and thin pulse. Laboratory examination and scoring: DSA28 score was 6.2 points, VAS score was 8 points, ESR (77.42 mm / h), CRP (39.82 mg / L); body composition analysis showed: BMI = 17.32, limb skeletal muscle mass = 17.97 kg, SMI = 5.31 kg / m 2 ; Maximum grip strength (17.3kg). Diagnosis: Rheumatoid arthritis and sarcopenia.

[0066] Prescription: 30g raw Astragalus, 12g peony, 9g cinnamon twig, 18g stir-fried Atractylodes, 9g angelica, 6g roasted Licorice root, 12g Notopterygium, 9g Saposhnikovia, 30g Sarcandra, 9g Caulis Sinomenii, 15g Angelica dahurica, 15g Polygonum cuspidatum, and 15g papaya.

[0067] Dosage and Administration: Ordinary water decoction, accurately weigh according to the formula, add 250 ml of water, boil for 40 minutes for the first decoction and 25 minutes for the second decoction, filter the residue while hot, mix the two decoctions and concentrate to 200 ml, take warm in two times, one dose per day.

[0068] Effect: After taking it for 14 days, the joint pain was relieved, the muscle heaviness was improved, the fatigue was relieved, and the appetite increased. The above-mentioned prescription was used as the main treatment. After taking it regularly for 5 months, there was no obvious pain in the joints, the joint range of motion was improved, the heaviness of the lower limb muscles disappeared, the fatigue disappeared, and the appetite increased significantly. At the second visit, the DSA28 score dropped to 2.3 points, the VAS score was 2 points, the ESR (16.21mm / h), and the CRP (7.62mg / L); body composition analysis showed: BMI = 18.68, SMI = 6.11kg / m2; maximum grip strength (20.1kg).

[0069] Treatment Case 4

[0070] Patient information: Huang, female, 42 years old, has had swelling and pain in both metacarpophalangeal joints, wrist joints, and knee joints for 5 years, accompanied by chills, cold hands and feet, and loose stools for more than 1 month. She had been treated in other hospitals and diagnosed with "rheumatoid arthritis", and the effect of taking medication was not obvious. Symptoms at the time of consultation: obvious swelling and pain in both metacarpophalangeal joints and knee joints, and limited flexion and extension of the index and ring finger joints of the right hand. Fear of cold, cold limbs, fatigue, poor appetite, loose stools, long urine, good sleep, pale tongue, white fur, and deep and thin pulse. Laboratory tests and scores: DSA28 score was 5.3 points, VAS score was 7 points, ESR (46.72mm / h), CRP (27.83mg / L); body composition analysis showed: BMI = 17.90, skeletal muscle content of limbs = 13.67kg, SMI = 5.02kg / m 2 ; Maximum grip strength (13.8kg). Diagnosis: Rheumatoid arthritis and sarcopenia.

[0071] Prescription: 30g raw astragalus, 15g peony, 12g cinnamon twig, 24g stir-fried atractylodes, 12g angelica, 6g roasted licorice, 12g notopterygium, 9g saposhnikovia divaricata, 30g scutellaria baicalensis, 9g green wind vine, 9g decocted aconite, 15g salt eucommia, and 6g cinnamon.

[0072] Dosage and Administration: Boil the processed aconite for 25 minutes first, and take the rest with ordinary water. Accurately weigh according to the recipe, add 250 ml of water, boil for 40 minutes for the first decoction and 25 minutes for the second decoction. Filter the residue while it is hot, mix the two decoctions and concentrate them to 200 ml. Take it warm twice, one dose per day.

[0073] Effect: After taking it for 12 days, the patient was less afraid of cold, less swollen and painful joints, had a better appetite, and had normal bowel movements. The above prescription was used as the main treatment, and after taking it regularly for 6 months, the patient was no longer afraid of cold, had no fatigue, had normal limb temperature, had an increased appetite, and had no obvious swelling or pain in the joints. At the next visit, the DSA28 score dropped to 2.2 points, the VAS score was 0 points, the ESR was 17.26 mm / h, and the CRP was 5.71 mg / L. The body composition analysis showed that the patient had a BMI of 18.83 and a SMI of 5.79 kg / m2. The maximum grip strength was 15.1 kg.

[0074] Treatment Case 5

[0075] Patient information: Wang, female, 55 years old, had pain in multiple joints of the whole body for 4 years and swelling of both knees for 2 years, which worsened with dizziness, tinnitus, and soreness and weakness of the limbs for more than 1 month. She was diagnosed with "rheumatoid arthritis" in another hospital, and was treated with oral Chinese and Western medicines, acupuncture and plastering, but the effect was not obvious. Symptoms at the time of consultation: swelling and pain in both knees, pain in both wrists, left elbow, and both metacarpophalangeal joints with difficulty in movement, morning stiffness lasting 30 minutes, deformation of both metacarpophalangeal joints, and limited flexion and extension. The limbs were obviously sore and weak, with dizziness, tinnitus, soreness of the waist and knees, thin body, poor appetite and good sleep, regular bowel movements, red tongue with little coating, and deep and fine pulse. Laboratory examination and scoring: DSA28 score was 6.9 points, VAS score was 8 points, ESR (69.34 mm / h), CRP (32.41 mg / L); body composition analysis showed: BMI = 16.87, limb skeletal muscle mass = 12.32 kg, SMI = 4.45 kg / m 2 ; Maximum grip strength (2.71kg, pain in left hand). Diagnosis: Rheumatoid arthritis and sarcopenia.

[0076] Prescription: 45g raw Astragalus, 15g peony, 9g cinnamon twig, 18g stir-fried Atractylodes, 12g angelica, 6g roasted Licorice root, 15g Notopterygium, 9g Saposhnikovia divaricata, 30g Sarcandra, 9g Caulis Sinomenii, 30g Rehmannia root, and 15g wine-boiled Cornus officinalis.

[0077] Dosage and Administration: Ordinary water decoction, accurately weigh according to the formula, add 250 ml of water, boil for 40 minutes for the first decoction and 25 minutes for the second decoction, filter the residue while hot, mix the two decoctions and concentrate to 200 ml, take warm in two times, one dose per day.

[0078] Effect: After taking it for 14 days, the pain in the joints of the whole body was relieved, the swelling of the knee joints was relieved, the fatigue was improved, there was occasional dizziness and tinnitus, and the appetite increased. The above-mentioned prescription was used as the main treatment with additions and subtractions. After taking it regularly for 8 months, there was no obvious swelling and pain in the joints, the range of motion of the joints was improved, the soreness and weakness of the limbs disappeared, there was no dizziness, tinnitus, soreness of the waist and knees, the appetite was significantly improved, and the weight increased by 3 kg. At the second visit, the DSA28 score dropped to 2.7 points, the VAS score was 2 points, ESR (18.32mm / h), CRP (8.02mg / L); body composition analysis showed: BMI = 18.53, SMI = 5.78kg / m2; maximum grip strength (13.22kg).

Claims

1. A Chinese medicine composition for treating rheumatoid arthritis sarcopenia, characterized in that: The raw material composition is, by weight: raw astragalus 9-60g, peony 9-15g, cinnamon twig 9-30g, stir-fried atractylodes 15-30g, angelica 9-30g, notopterygium wilfordii 9-15g, siler 9-15g, swollen knotweed 9-30g, green wind vine 6-12 g, and roasted liquorice 3-6g.

2. A Chinese medicine composition for treating rheumatoid arthritis sarcopenia, characterized in that: The raw material composition is, by weight: raw astragalus 9-60g, peony 9-15g, cinnamon twig 9-30g, stir-fried atractylodes 15-30g, angelica 9-30g, notopterygium wilfordii 9-15g, siler 9-15g, scutellaria baicalensis 9-30g, scutellaria baicalensis 6-12 g, roasted licorice root 3-6g, codonopsis pilosula 15-30g, and poria 15-30g.

3. A Chinese medicine composition for treating rheumatoid arthritis sarcopenia, characterized in that: The raw material composition is, by weight: raw astragalus 9-60g, peony 9-15g, cinnamon twig 9-30g, stir-fried atractylodes 15-30g, angelica 9-30g, notopterygium wilfordii 9-15g, siler 9-15g, scutellaria baicalensis 9-30g, cnidium monnieri 6-12g, roasted liquorice root 3-6g, cynanchum wilfordii 9g -12g, and scutellaria baicalensis 10g -30g.

4. A Chinese medicine composition for treating rheumatoid arthritis sarcopenia, characterized in that: The raw materials are composed of, by weight: 9-60g raw astragalus, 9-15g peony, 9-30g cinnamon twig, 15-30g stir-fried atractylodes, 9-30g angelica, 9-15g notopterygium, 9-15g siler, 9-15g scutellaria, 9-30g scutellariae, 6-12g green wind vine, 3-6g roasted liquorice, 15g angelica pubescens, 15g polygonum cuspidatum, and 15g papaya.

5. A Chinese medicine composition for treating rheumatoid arthritis sarcopenia, characterized in that: The raw materials are composed of, by weight: raw astragalus 9-60g, peony 9-15g, cinnamon twig 9-30g, stir-fried atractylodes 15-30g, angelica 9-30g, notopterygium wilfordii 9-15g, siler 9-15g, scutellaria 9-30g, scutellaria baicalensis 6-12 g, roasted licorice 3-6g, cooked aconite 9g, salted eucommia 15g, and cinnamon 6g.

6. A Chinese medicine composition for treating rheumatoid arthritis sarcopenia, characterized in that: The raw materials are composed of, by weight: 9-60g raw astragalus, 9-15g peony, 9-30g cinnamon twig, 15-30g stir-fried atractylodes, 9-30g angelica, 9-15g notopterygium, 9-15g siler, 9-15g saposhnikovia, 9-30g scutellaria, 6-12g green wind vine, 3-6g roasted liquorice, 30g rehmannia root, and 15g cornus officinalis.

7. A method for preparing the Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: accurately weighing according to the formula, adding 250 ml of water, first decocting for 40 minutes, second decocting for 25 minutes, filtering the residue while hot, and mixing the two decoctions and concentrating them into 200 ml.

8. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicament for treating rheumatoid arthritis sarcopenia.

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