A Chinese medicine for treating hypertension with liver yang hyperactivity syndrome

Abstract

A traditional Chinese medicine for treating hypertension liver yang hyperactivity syndrome comprises the following raw materials by weight: 18-23g of Tribulus terrestris, 18-23g of Bidens pilosa, 18-23g of Astragalus membranaceus, 10-14g of Plantago seed, 8-11g of Chrysanthemum, 8-11g of Cibotium barometz, 8-11g of Gastrodia elata, 8-11g of Uncaria rhynchophylla, 8-12g of Semen Cassiae, 8-12g of Pheretima and 13-17g of Pueraria root; the raw materials are mixed, soaked in water and decocted twice, firstly adding water 8 times of the total weight thereof and decocting for 1 hour to obtain a first decoction, secondly adding water 6 times of the total weight thereof and decocting for 0.5 hour to obtain a second decoction, combining the two decoctions, filtering and concentrating to 1 / 5 of the total volume to obtain the traditional Chinese medicine; the traditional Chinese medicine has abundant raw materials, simple preparation method, easy production and convenient administration, and has obvious effect in treating hypertension liver yang hyperactivity syndrome, good safety and huge social and economic benefits.

Description

Technical Field

[0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating hypertension liver yang hyperactivity syndrome. Background Art

[0002] Hypertension is a common clinical disease that can cause lesions in the heart, brain, kidneys, and peripheral blood vessels, resulting in various clinical events. The high incidence of hypertension seriously consumes medical resources and imposes a huge economic burden on families and society. At present, drugs for the treatment of essential hypertension have many side effects and still need to be further improved. Finding effective drugs with fewer side effects to treat stage 1 hypertension is the focus of current research.

[0003] Hypertension belongs to the category of "vertigo" in traditional Chinese medicine. Common clinical symptoms include dizziness and blurred vision. Most of them are caused by liver and kidney yin deficiency, qi and blood deficiency, and wind, fire, phlegm and blood stasis. Treatment is mainly to tonify the deficiency and purge the excess, and adjust yin and yang. Traditional Chinese medicine has unique advantages such as multiple pathways, multiple targets and few side effects. It can significantly improve the symptoms of hypertension and delay the progression of the disease. Under the guidance of traditional Chinese medicine theory, the application research of innovative Chinese medicine combination in the treatment of hypertension liver yang hyperactivity syndrome has important medical and sociological significance. Summary of the invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine for treating hypertension and liver yang hyperactivity syndrome, which can effectively solve the problem of medication for treating hypertension and liver yang hyperactivity syndrome.

[0005] To achieve the above purpose, the technical solution provided by the present invention is a traditional Chinese medicine for treating hypertension with liver yang hyperactivity syndrome, comprising the following raw materials by weight: 18-23g of Tribulus terrestris, 18-23g of Bidens pilosa, 18-23g of Astragalus membranaceus, 10-14g of Plantago asiatica, 8-11g of Chrysanthemum, 8-11g of Cibotium barometz, 8-11g of Gastrodia elata, 8-11g of Uncaria rhynchophylla, 8-12g of Semen Cassiae, 8-12g of Pheretima and 13-17g of Pueraria root; the above raw materials are mixed, soaked in water and decocted twice, the first time, 8 times the volume of water of the total weight is added and decocted for 1 hour to obtain the first decoction, the second time, 6 times the volume of water of the total weight is added to the filter residue and decocted for 0.5 hour to obtain the second decoction, the two decoctions are combined and filtered, and concentrated to 1 / 5 of the total volume to obtain; the weight volume is the weight in g and the liquid in ml.

[0006] The invention has abundant raw materials, a simple preparation method, is easy to produce, is convenient to take, has obvious effect in treating hypertension liver yang hyperactivity syndrome, has good safety, and has huge social and economic benefits. DETAILED DESCRIPTION

[0007] The specific implementation modes of the present invention are described in detail below in conjunction with the embodiments.

[0008] The specific implementation of the present invention is given by the following examples.

[0009] Example 1

[0010] A traditional Chinese medicine for treating hypertension and liver yang hyperactivity syndrome comprises the following raw materials measured by weight: 20g of Tribulus terrestris, 20g of Bidens pilosa, 20g of Astragalus membranaceus, 12g of Plantago seed, 9g of Chrysanthemum, 9g of Cibotium barometz, 9g of Gastrodia elata, 9g of Uncaria rhynchophylla, 10g of Semen Cassiae, 10g of Pheretima and 15g of Pueraria root; the above raw materials are mixed, soaked in water and decocted twice, the first time water of 8 times the total weight is added and decocted for 1 hour to obtain the first decoction, the second time water of 6 times the total weight is added to the filter residue and decocted for 0.5 hour to obtain the second decoction, the two decoctions are combined and filtered, and concentrated to 1 / 5 of the total volume to obtain the product.

[0011] Example 2

[0012] A traditional Chinese medicine for treating hypertension and liver yang hyperactivity syndrome comprises the following raw materials measured by weight: 18g of Tribulus terrestris, 18g of Bidens pilosa, 18g of Astragalus membranaceus, 10g of Plantago seed, 8g of Chrysanthemum, 8g of Cibotium barometz, 8g of Gastrodia elata, 8g of Uncaria rhynchophylla, 8g of Semen Cassiae, 8g of Pheretima and 13g of Pueraria root.

[0013] Example 3

[0014] A traditional Chinese medicine for treating hypertension and liver yang hyperactivity syndrome, comprising the following raw materials by weight: 23g of Tribulus terrestris, 23g of Bidens pilosa, 23g of Astragalus membranaceus, 14g of Plantago seed, 11g of Chrysanthemum, 11g of Cibotium barometz, 11g of Gastrodia elata, 11g of Uncaria rhynchophylla, 12g of Semen Cassiae, 12g of Pheretima and 17g of Pueraria root.

[0015] Example 4

[0016] A traditional Chinese medicine for treating hypertension and liver yang hyperactivity syndrome comprises the following raw materials measured by weight: 19g of Tribulus terrestris, 22g of Bidens pilosa, 20g of Astragalus membranaceus, 13g of Plantago seed, 9g of Chrysanthemum, 9g of Cibotium barometz, 10g of Gastrodia elata, 11g of Uncaria rhynchophylla, 11g of Semen Cassiae, 9g of Pheretima and 14g of Pueraria root.

[0017] Example 5

[0018] A traditional Chinese medicine for treating hypertension and liver yang hyperactivity syndrome comprises the following raw materials measured by weight: 22g of Tribulus terrestris, 19g of Bidens pilosa, 22g of Astragalus membranaceus, 11g of Plantago seed, 10g of Chrysanthemum, 10g of Cibotium barometz, 9g of Gastrodia elata, 8g of Uncaria rhynchophylla, 9g of Semen Cassiae, 11g of Pheretima and 16g of Pueraria root.

[0019] In the above-mentioned drug composition, among them:

[0020] Tribulus terrestris: bitter, pungent, neutral. Enters the liver, lung, kidney, and heart meridians. It has the effects of calming the liver and suppressing yang, clearing the liver and improving eyesight, dispelling wind and relieving itching, soothing the liver and relieving depression, and promoting blood circulation and dispersing stagnation. It is mainly used to treat headaches and dizziness, chest and flank pain and breast pain, milk blockage, mastitis, red eyes and cataracts, urticaria and itching, etc.

[0021] Bidens pilosa: sweet, light, bitter, slightly cold. Enters the liver, lung, and large intestine meridians. Has the effects of soothing the liver and dispelling wind, clearing away heat and detoxifying, and dispersing blood stasis and reducing swelling.

[0022] Astragalus membranaceus: sweet in taste, warm in nature, enters the liver and kidney meridians, has the effect of nourishing the liver and improving eyesight, and can be used for symptoms such as liver and kidney deficiency, low back and knee pain, dizziness and blurred vision.

[0023] Plantago seed: sweet in taste, cold in nature. Enters the kidney and bladder meridians. Has the effects of clearing away heat, promoting diuresis, relieving stranguria, dispelling dampness and stopping diarrhea, improving eyesight, and removing phlegm. Can nourish the liver and improve eyesight, improve symptoms of red, swollen and painful eyes, dark and painful eyes. Used for hot stranguria, edema, diarrhea caused by summer heat, red, swollen and painful eyes, and cough caused by phlegm and heat.

[0024] Chrysanthemum: sweet, bitter, slightly cold. It has the effects of dispersing wind and heat, calming the liver and improving eyesight. It is used for wind-heat cold, headache, dizziness, red and swollen eyes, and blurred vision.

[0025] Green box: bitter, slightly cold, non-toxic. Enters the liver meridian. Clears the liver, brightens the eyes, removes cataracts. Used for red, swollen and painful eyes; cataracts; blurred vision; hypertension; epistaxis; itchy skin due to wind-heat; sores and ringworms.

[0026] Gastrodia elata: sweet, neutral, and enters the liver meridian. It is sweet, slow, heavy, soft and moist without being dry, neutral and impartial, and enters the liver meridian. It is good at calming wind and stopping spasms, calming liver yang, and treating liver yang and liver wind symptoms, regardless of cold, heat, deficiency or excess. It can dispel wind and dredge meridians, and treat arthralgia, limb numbness, and paralysis of hands and feet.

[0027] Uncaria rhynchophylla: sweet and cool in nature. Enters the liver and pericardium meridians. Sweet, mild and mild, slightly cold and clear, light and penetrating, mainly enters the liver meridian and also enters the pericardium meridian. It has the effects of calming wind and relieving convulsions, clearing heat and calming the liver. It is mainly used to treat dizziness and vertigo caused by hyperactivity of yang, headache and swelling caused by liver heat, and convulsions caused by convulsions.

[0028] Lithospermum officinale: salty, cold, enters the liver meridian. Lithospermum officinale is heavy and calming, salty and cold, clearing and tonifying, specifically enters the liver meridian, and slightly benefits the yin. It has the effects of calming the liver and suppressing yang, clearing the liver and improving eyesight. It is an essential medicine for treating liver yang hyperactivity and liver heat eye diseases. It is often used for headaches, dizziness, red eyes, blurred vision, and amblyopia.

[0029] Earthworm: salty in taste, cold in nature, enters the liver, spleen, and bladder meridians. It has the effects of clearing away heat and calming the nerves, promoting blood circulation, clearing the lungs and relieving asthma, and diuresis. It is often used for high fever and coma, epilepsy and convulsions, joint pain, limb numbness, hemiplegia, lung heat and cough, edema and oliguria.

[0030] Pueraria root: sweet, pungent, and cool. It enters the spleen, stomach, and lung meridians. It is sweet and pungent, lightly lifting and dispersing, and is mild and slightly cool and can clear. It can not only penetrate and relieve wind-heat on the surface of the muscles, relieve muscles and reduce fever, and release the exterior, and cause rashes, but also encourage the spleen and stomach to rise and produce fluid to quench thirst, and raise yang to stop diarrhea. It is most suitable for treating stiff neck and back pain and Yangming headache, regardless of cold or heat, deficiency or excess, with or without sweat. It can be used raw to dissipate, clear, and produce fluid, while stewed is better at lifting and less clearing.

[0031] The above-mentioned medicines are effectively combined and support each other. In the formula, Tribulus terrestris and Bidens pilosa are the main medicines for soothing the liver and dispelling wind, while Plantago seed, Gastrodia elata, Uncaria rhynchophylla and Semen Cassiae can calm the liver, suppress yang and improve eyesight. When used together with the main medicine, they strengthen the effect of soothing the liver and dispelling wind, and are the assistant medicines; Astragalus membranaceus enters the liver and kidneys to replenish their deficiency, Chrysanthemum and Indigofera chinensis are slightly cold in nature and can control the hyperactivity of liver yang, clear the liver and improve eyesight to help the main medicine clear the liver and improve eyesight, Pheretima root can calm the wind, activate the collaterals and help lower the liver yang, and are all adjuvant medicines; Pueraria root is a Yangming meridian medicine that can relax muscles and relieve restlessness, and lead all medicines into the head and neck, and is the guiding medicine.

[0032] As can be seen from the above, the Chinese medicine for treating hypertension liver yang hyperactivity syndrome of the present invention has mutually supportive drugs, reasonable compatibility, and scientific preparation, and is effectively used for hypertension liver yang hyperactivity syndrome, and clinical trials have achieved very good beneficial technical effects. Taking Example 1 as an example, the relevant experimental data are as follows:

[0033] 1. Case selection:

[0034] (1) Inclusion criteria

[0035] ①18 years old ≤ ≤ 70 years old;

[0036] ② Meet the diagnostic criteria for hypertension in Western medicine, according to the "Guidelines for the Prevention and Treatment of Hypertension in China" (revised version in 2018):

[0037] Without taking antihypertensive drugs, the blood pressure in the clinic was measured three times on different days, and SBP ≥ 140 mmHg and (or) DBP ≥ 90 mmHg. SBP ≥ 140 mmHg and DBP < 90 mmHg are isolated systolic hypertension.

[0038] Patients with a history of hypertension who are currently taking antihypertensive drugs should still be diagnosed with hypertension even if their blood pressure is lower than 140 / 90 mmHg;

[0039] ③ Meet the diagnostic criteria of TCM vertigo due to liver yang hyperactivity syndrome, refer to the "Guidelines for Clinical Research of New Chinese Medicines" and "Chinese Medicine Internal Medicine":

[0040] Main symptoms: dizziness, headache;

[0041] Secondary symptoms: bitter taste in the mouth, tinnitus, insomnia and dreaminess, aggravated by fatigue, depression and anger, even falling down, flushed face, irritability, tremors of limbs; tongue and pulse: red tongue with yellow coating, stringy or rapid pulse;

[0042] The diagnosis can be made if the main symptom and ≥ two secondary symptoms are present.

[0043] ④Voluntarily sign the informed consent form.

[0044] (2) Exclusion criteria

[0045] ① Patients with severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and blood system diseases;

[0046] ②Patients with mental illness;

[0047] ③ Pregnant, lactating women and those planning to become pregnant;

[0048] ④ Those with allergic constitution and allergic to the medications they take;

[0049] ⑤ Those who have recently participated in other research and those who have taken Chinese herbal medicine or Chinese patent medicine;

[0050] ⑥ Patients who are judged by the researchers to be unsuitable for participating in this trial.

[0051] 2. Treatment methods:

[0052] According to case selection, a total of 120 patients were selected and randomly divided into two groups, 60 cases in the treatment group and 60 cases in the control group. There was no significant difference between the two groups in terms of gender, age, etc.

[0053] ① The control group took losartan potassium tablets (Zhejiang Huahai Pharmaceutical Co., Ltd., specification: 50 mg) orally, 1 tablet each time, once a day, for 4 weeks, a total of 1 course of treatment;

[0054] ② The experimental group was given the Chinese medicine preparation prepared in Example 1 (one dose), decocted in water and taken warm twice a day for 4 weeks, with a total of 1 course of treatment.

[0055] 3. Observation indicators and efficacy evaluation criteria:

[0056] 3.1 Observation indicators:

[0057] ①Main efficacy indicators: changes in systolic and diastolic blood pressure levels before and after treatment;

[0058] ② Secondary efficacy indicators: TCM syndrome scores before and after treatment, referring to the "Guidelines for Clinical Research of New Chinese Medicines" (Trial) and "Standards for Diagnosis and Efficacy of TCM Internal Medicine Diseases", the main symptoms are divided into four levels: none, mild, moderate, and severe, scored 0, 2, 4, and 6 points respectively; the secondary symptoms are divided into four levels: none, mild, moderate, and severe, scored 0, 1, 2, and 3 points respectively.

[0059] Markedly effective: The main and secondary clinical symptoms basically or completely disappeared, and the symptom score decreased by >70%;

[0060] Effective: Clinical symptoms improved significantly, with syndrome scores reduced by 30% to 70%;

[0061] Ineffective: clinical symptoms have no significant improvement, and the syndrome score decreases by less than 30%;

[0062] Aggravation: Clinical symptoms worsen, and the score after treatment exceeds the score before treatment.

[0063] ③Safety indicators: observe vital signs, routine blood tests, routine urine tests; routine stool tests (when there is bowel movement), fecal occult blood (when there is bleeding tendency and there is bowel movement), liver and kidney function indicators. TCM syndrome scoring was performed at the 0th and 4th weeks of treatment; routine blood tests, routine urine tests, routine stool tests, liver function, and kidney function were tested at the 0th, 1st, and 4th weeks.

[0064] 3.2 Clinical efficacy criteria:

[0065] Markedly effective: After treatment, clinical symptoms basically or completely disappear, and blood pressure drops back to normal or approaches normal;

[0066] Effective: After treatment, clinical symptoms improved and blood pressure decreased slightly;

[0067] Ineffective: After treatment, clinical symptoms slightly improved or not improved, and blood pressure did not drop significantly;

[0068] Effective rate = (number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0069] Statistical Analysis

[0070] SPSS 22.0 statistical software was used for analysis. Indicates that the independent sample t test was used for inter-group comparisons with normal distribution, and the independent sample rank sum test was used for non-normal distribution. The paired sample t test was used for intra-group comparisons with normal distribution, and the paired sample rank sum test was used for non-normal distribution. The chi-square test was used for count data, and the rank sum test was used for rank data. P<0.05 was considered statistically significant.

[0071] V. Test Results

[0072] 5.1 Comparison of blood pressure between the two groups before and after treatment:

[0073] After treatment, blood pressure in both groups decreased significantly (P<0.05), and the overall antihypertensive effect of the experimental group was better than that of the control group. Compared with the control group, the SBP antihypertensive effect of the experimental group was better (P<0.05), as shown in Table 1.

[0074] Table 1 Comparison of blood pressure between the two groups before and after treatment

[0075]

[0076] Note: Compared with the group before treatment, * P<0.05, **P<0.01; compared with the control group after treatment, # P<0.05.

[0077] 5.2 Comparison of total TCM syndrome scores between the two groups before and after treatment

[0078] After treatment, the total score of TCM syndrome decreased in both groups (P<0.05), and the decrease in the total score of TCM syndrome in the experimental group was lower than that in the control group (P<0.05). The results are shown in Table 2.

[0079] Table 2 Comparison of total scores of TCM syndromes between the two groups before and after treatment

[0080]

[0081] Note: Compared with the group before treatment, * P<0.01; compared with the control group after treatment, # P<0.05.

[0082] 5.3 Comparison of clinical efficacy between the two groups

[0083] The total effective rate of the experimental group was higher than that of the control group (P<0.05). The results are shown in Table 3.

[0084] Table 3 Comparison of clinical efficacy between the two groups n (%)

[0085]

[0086] Note: Compared with the control group, # P<0.01.

[0087] 5.4 Safety of the two groups before and after treatment

[0088] No adverse events occurred in both groups during the treatment, and no obvious abnormal changes were found in blood routine, urine routine, stool routine, liver function, and kidney function before and after treatment.

[0089] Each of the above experiments was repeated three times, and the results were consistent. At the same time, while performing the above experiments on Example 1, the present invention also performed the same experiments on Examples 2-5, and obtained the same or similar results as Example 1, which are not listed here one by one, indicating that the present invention has good effects and stable and reliable therapeutic effects.

[0090] VI. Conclusion

[0091] In summary, the present invention has reasonable components, scientific compatibility, simple and easy preparation method, low cost, good effect, easy to take, and obvious effect in treating hypertension and liver yang hyperactivity syndrome, with a total effective rate of up to 86.67%, and can effectively reduce systolic and diastolic blood pressure, and reduce the total score of TCM symptoms of hypertension and liver yang hyperactivity syndrome, with significant clinical efficacy, safe medication, and no obvious adverse reactions; and the present invention has abundant raw materials, simple preparation method, mutual support and cooperation, and can exert the efficacy of the drug while reducing side effects on the body, and is effectively used for hypertension and liver yang hyperactivity syndrome, and has achieved satisfactory results through the above clinical trials, with huge economic and social benefits.

[0092] It should be noted that the technical feature and key of the present application is the compatibility of the Chinese medicine composition. The decoction (decoction) given above is only an embodiment of a dosage form. All technical schemes that are essentially the same as those of the present application made by equivalent and equivalent replacement means, or various dosage forms suitable for oral administration prepared by conventional preparation methods using the Chinese medicine composition of the present application, such as powders (granules), granules, pills, tablets, oral liquids, capsules, extract powders, etc., all fall within the scope of protection of the present application.

Claims

1. A Chinese medicine for treating hypertension due to hyperactivity of liver yang, characterized in that: The invention is prepared from the following raw materials by weight: 18-23g of Tribulus terrestris, 18-23g of Bidens pilosa, 18-23g of Astragalus complanatus, 10-14g of Plantago seed, 8-11g of Chrysanthemum, 8-11g of Cibotium barometz, 8-11g of Gastrodia elata, 8-11g of Uncaria rhynchophylla, 8-12g of Semen Cassiae, 8-12g of Pheretima and 13-17g of Pueraria root; the above raw materials are mixed, soaked in water and decocted twice, the first time, 8 times the volume of water by total weight is added and decocted for 1 hour to obtain the first decoction, the second time, 6 times the volume of water by total weight is added to the filter residue and decocted for 0.5 hour to obtain the second decoction, the two decoctions are combined and filtered, and concentrated to 1 / 5 of the total volume to obtain the product; the weight and volume are weight in g and liquid in ml.

2. The Chinese medicine for treating hypertension due to hyperactivity of liver yang according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 20g of Tribulus terrestris, 20g of Bidens pilosa, 20g of Astragalus membranaceus, 12g of Plantago seed, 9g of Chrysanthemum, 9g of Cibotium barometz, 9g of Gastrodia elata, 9g of Uncaria rhynchophylla, 10g of Semen Cassiae, 10g of Pheretima and 15g of Pueraria root.

3. The Chinese medicine for treating hypertension due to hyperactivity of liver yang according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 18g of Tribulus terrestris, 18g of Bidens pilosa, 18g of Astragalus complanatus, 10g of Plantago seed, 8g of Chrysanthemum, 8g of Cibotium barometz, 8g of Gastrodia elata, 8g of Uncaria rhynchophylla, 8g of Semen Cassiae, 8g of Pheretima and 13g of Pueraria root.

4. The Chinese medicine for treating hypertension due to hyperactivity of liver yang according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 23g of Tribulus terrestris, 23g of Bidens pilosa, 23g of Astragalus complanatus, 14g of Plantago seed, 11g of Chrysanthemum, 11g of Cibotium officinale, 11g of Gastrodia elata, 11g of Uncaria rhynchophylla, 12g of Semen Cassiae, 12g of Pheretima and 17g of Pueraria root.

5. The Chinese medicine for treating hypertension due to hyperactivity of liver yang according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 19g of Tribulus terrestris, 22g of Bidens pilosa, 20g of Astragalus complanatus, 13g of Plantago seed, 9g of Chrysanthemum, 9g of Cibotium barometz, 10g of Gastrodia elata, 11g of Uncaria rhynchophylla, 11g of Semen Cassiae, 9g of Pheretima and 14g of Pueraria root.

6. The Chinese medicine for treating hypertension due to hyperactivity of liver yang according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 22g of Tribulus terrestris, 19g of Bidens pilosa, 22g of Astragalus complanatus, 11g of Plantago seed, 10g of Chrysanthemum, 10g of Cibotium barometz, 9g of Gastrodia elata, 8g of Uncaria rhynchophylla, 9g of Semen Cassiae, 11g of Pheretima and 16g of Pueraria root.

Images