A sunscreen composition based on xanthoceras oil and oil-soluble ultraviolet absorber and application

Abstract

The present application relates to a kind of based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber sunscreen composition and application, in the sunscreen composition, oil-soluble ultraviolet absorber includes diethylaminohydroxybenzoyl benzoyl acid hexyl ester (APLUS), methoxycinnamic acid ethylhexyl (MC80), benzophenone-3, Xanthoceras sorbifolia Bunge oil and fat-soluble sunscreen agent weight content ratio is 100 :(10~1).The sunscreen composition is used to prepare sunscreen oil product and W / O sunscreen cream product.The sunscreen composition of the present application can be well solved the stability of oil-soluble ultraviolet absorber in formula, has synergistic sunscreen effect in sunscreen oil and sunscreen cream product, significantly improves SPF value, PA value, the survival rate and swallowing rate of nematode under ultraviolet irradiation.Compared with prior art, the present application uses natural oil to improve the safety of sunscreen product, high efficiency, while can reduce the use of chemical sunscreen agent, natural, safe and effective.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and in particular to a sunscreen composition and its application based on *Sapindus mukorossi* oil and an oil-soluble ultraviolet absorber. Background Technology

[0002] Ultraviolet (UV) radiation is a type of electromagnetic radiation emitted by the sun. The main forms of UV radiation include UVA (315-400nm), UVC (290-315nm), and UVB (100-290nm). Skin exposure to UV radiation can lead to short-term sunburn and tanning, and long-term photoaging, DNA damage, and skin cancer. Therefore, using sunscreen products to reduce the damage of UV radiation to the skin is essential. While sunscreen can effectively reduce the damage of UV radiation to the skin, the safety concerns of the active ingredients in currently permitted sunscreen products, such as their easy absorption into the bloodstream and their tendency to decompose and cause skin allergies and irritation, remain a concern for researchers and consumers.

[0003] The fruit of the *Xanthoceras sorbifolium* is sweet and neutral in nature, non-toxic, and has a chestnut-like flavor. It is believed to invigorate qi, nourish the five internal organs, calm the mind, nourish blood, and promote muscle regeneration. Long-term consumption is said to promote health and longevity. A decoction made from its branches is used to treat rheumatism and strengthen muscles and bones. In addition to its wide range of medicinal uses, *Xanthoceras sorbifolium* components possess free radical scavenging, anti-aging, cardiovascular disease prevention, anti-inflammatory, antiviral, and antibacterial properties. *Xanthoceras sorbifolium* oil is a natural oil extracted from the fruit. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art by providing a sunscreen composition and its application based on *Sapindus mukorossi* oil and an oil-soluble ultraviolet absorber. The *Sapindus mukorossi* oil in this invention is natural and safe, and together with the oil-soluble ultraviolet absorber, it has a synergistic effect in sun protection. When applied to sunscreen oil products and W / O sunscreen products, it can reduce the amount of oil-soluble ultraviolet absorber used and significantly improve the sun protection effect.

[0005] The objective of this invention can be achieved through the following technical solutions:

[0006] This invention provides a sunscreen composition based on *Sapindus mukorossi* oil and an oil-soluble ultraviolet absorber, the sunscreen composition comprising the following components and their weight percentages:

[0007] 100g of *Sapindus mukorossi* oil;

[0008] Oil-soluble ultraviolet absorber 1~10.

[0009] Furthermore, the oil-soluble ultraviolet absorber is one or more of benzophenone-3, MC80 (ethylhexyl methoxycinnamate), and APLUS (hexyl bis(ethylaminohydroxybenzoyl)benzoate).

[0010] The application further provides a preparation method of the sunscreen composition based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber.

[0011] Further, the heating and dissolving temperature is 75-95°C.

[0012] Further, the heating and dissolving process is accelerated by stirring at a stirring rate of 100-300 rpm.

[0013] Further, the cooling temperature is room temperature.

[0014] The application further provides an application of the sunscreen composition based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber, which is used for preparing sunscreen oil products and W / O sunscreen cream products.

[0015] The application further provides a sunscreen oil product based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber, which comprises the sunscreen composition, components and mass percentage contents as follows:

[0016] Sunscreen composition 94.0%-97.5%;

[0017] Solid oil 1.0-5.0%;

[0018] Antioxidant 0.5%;

[0019] Preservative 0-0.5%.

[0020] Further, the solid oil comprises one or more of shea butter, stearic acid, monoglyceride, cetostearyl alcohol and behenyl alcohol.

[0021] Further, the antioxidant is di-tert-butyl-p-cresol.

[0022] Further, the preservative comprises one or more of p-hydroxyacetophenone, nipagin and nipasol.

[0023] The application further provides a preparation method of the sunscreen oil product based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber, which comprises the following steps:

[0024] A1: preparing materials according to the following mass proportions of components:

[0025] Sunscreen composition 94.0%-97.5%,

[0026] Solid oil 1.0-5.0%,

[0027] Antioxidant 0.5%,

[0028] Preservative 0~0.5%;

[0029] A2: The sunscreen composition, solid oil and fat are mixed in the above proportions, heated to 75~95℃ in a water bath, stirred uniformly at a speed of 100~300rpm, then cooled to 50~60℃, the antioxidant and preservative are added, stop stirring when the temperature reaches room temperature, discharge, and the target product sunscreen oil product is obtained.

[0030] The application also provides a W / O sunscreen product based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber, which comprises the sunscreen composition, components and mass percentage contents as follows:

[0031] Sunscreen composition 11%~24%;

[0032] Liquid oil and fat 4%~12%;

[0033] Emulsifier 1.3%~2.3%;

[0034] Moisturizer 5%~8%;

[0035] Preservative 0~0.5%;

[0036] Thickening agent 0.05%~0.6%;

[0037] Sodium chloride 0.5%~1.0%;

[0038] Water 51.6%~78.15%.

[0039] Further, the liquid oil and fat comprises one or more of dimethicone, silylated silica, cyclomethicone.

[0040] Further, the emulsifier comprises one or more of cetyl peg / propyleneglycol-10 / 1 dimethicone, cetyl stearyl alcohol, cetyl dimethicone, magnesium stearate.

[0041] Further, the moisturizer comprises one or more of glycerin, polyethylene glycol, 1,3-butanediol.

[0042] Further, the preservative is one of p-hydroxyacetophenone, propyl paraben, hydroxybenzoate.

[0043] Further, the thickening agent comprises xanthan gum or carbomer.

[0044] The application also provides a preparation method of a W / O sunscreen product based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber, comprising the following steps:

[0045] B1: Prepare the components in the following mass proportions:

[0046] sunscreen composition 11%~24%,

[0047] liquid oil 4%~12%,

[0048] emulsifier 1.3%~2.3%,

[0049] moisturizer 5%~8%,

[0050] preservative 0~0.5%,

[0051] thickening agent 0.05%~0.6%,

[0052] sodium chloride 0.5%~1.0%,

[0053] deionized water 51.6%~78.15%;

[0054] B2: mix the sunscreen composition, liquid oil and emulsifier, heat and stir until the system is uniform to obtain an oil phase;

[0055] B3: dissolve the thickening agent, moisturizer and sodium chloride in deionized water, heat and stir to obtain an aqueous phase;

[0056] B4: stir the oil phase obtained in step B2, add the aqueous phase obtained in step B3 to it, continue heating and stirring until mixed uniformly, homogenize, cool, and obtain a mixture;

[0057] B5: add the preservative to the mixture obtained in step B4, stir to room temperature, discharge, and obtain the target product W / O sunscreen product.

[0058] Further, in step B2, the temperature for heating and stirring to dissolve is 75~95℃, and the stirring speed is 100~300rpm.

[0059] In step B3, the heating temperature is 75~95℃, and the stirring speed is 100~300rpm.

[0060] In step B4, the heating temperature is 75~95℃, the stirring speed is 200~800rpm, the homogenization speed is 1000~1500rpm, and the cooling temperature is 50~60℃.

[0061] In step B5, the stirring speed is 50~150rpm.

[0062] Compared with the prior art, the present application has the following advantages:

[0063] The sunscreen composition of the present application is a combination of natural oil and oil-soluble ultraviolet absorber, Xanthoceras sorbifolia Bunge oil is a unique healthy woody edible oil in China, which has natural and safe characteristics, and the oil-soluble ultraviolet absorber has good compatibility with it; the precipitation of the oil-soluble ultraviolet absorber in the sunscreen product can be reduced, the sunscreen effect is obviously improved, and the sunscreen effect is better than that of a single sunscreen agent dissolved in white oil or common oil such as silicone oil; the composition can be applied to sunscreen oil products and W / O sunscreen cream products, so that the amount of oil-soluble ultraviolet absorber can be reduced or the sunscreen effect can be significantly improved. BRIEF DESCRIPTION OF DRAWINGS

[0064] Figure 1 Physical pictures of sunscreen oil products 3, 15 and 18 obtained in Example 8, Comparative Example 9 and Comparative Example 12;

[0065] Figure 2 Effects of different oils and different sunscreen oil products on the survival rate of C. elegans under UV;

[0066] Figure 3 Effects of different oils and different sunscreen oil products on the phagocytosis rate of C. elegans under UV. DETAILED DESCRIPTION

[0067] The present application will be described in detail below in combination with the drawings and specific examples. The present embodiment is implemented on the premise of the technical solution of the present application, and detailed implementation modes and specific operation processes are given, but the protection scope of the present application is not limited to the following examples. Based on the given examples, all other examples obtained by those skilled in the art without making creative efforts belong to the scope of protection of the present application.

[0068] Unless otherwise specified, the reagents, methods, instruments and equipment used in the present application are conventional reagents, methods, instruments and equipment in the art.

[0069] In the following examples, the Xanthoceras sorbifolia Bunge oil is a cosmetic grade, which is purchased from Shanghai Baihaobo Chemical Co., Ltd.; the APLUS, MC80 and benzophenone-3 are cosmetic grades, which are purchased from Guangzhou Longhui Trade Co., Ltd.; the shea butter, glycerin, xanthan gum, p-hydroxyacetophenone, magnesium stearate and white oil are cosmetic grades, which are purchased from National Pharmaceutical Group Chemical Reagent Co., Ltd.; the silylated silica, dimethicone and cetyl polyethylene glycol / polypropylene glycol-10 / 1 dimethicone are cosmetic grades, which are purchased from Wincreate Speciality Chemicals (Shanghai) Co., Ltd.

[0070] Example 1

[0071] A sunscreen composition based on Xanthoceras sorbifolia Bunge oil and APLUS, which comprises the following components and weight contents:

[0072] Shorea fat 100;

[0073] APLUS 8.

[0074] The preparation method is: take 0.8g APLUS into 10g Shorea fat, stir at 200rpm / min in 85℃ water bath until the system is uniform, and then cool to room temperature to obtain sunscreen composition 1.

[0075] Example 2

[0076] A sunscreen composition based on Shorea fat and MC80, which includes the following components and weight content:

[0077] Shorea fat 100;

[0078] MC80 8.

[0079] The preparation method is: take 0.8g MC80 into 10g Shorea fat, stir at 200rpm / min in 85℃ water bath until the system is uniform, and then cool to room temperature to obtain sunscreen composition 2.

[0080] Example 3

[0081] A sunscreen composition based on Shorea fat and benzophenone-3, which includes the following components and weight content:

[0082] Shorea fat 100;

[0083] Benzophenone-3 8.

[0084] The preparation method is: take 0.8g benzophenone-3 into 10g Shorea fat, stir at 200rpm / min in 85℃ water bath until the system is uniform, and then cool to room temperature to obtain sunscreen composition 3.

[0085] Example 4

[0086] A sunscreen composition based on Shorea fat and APLUS, which is mostly the same as Example 1, except that the component mass content is adjusted as follows to obtain sunscreen composition 4:

[0087] Shorea fat 100;

[0088] APLUS 1.

[0089] Example 5

[0090] A sunscreen composition based on Shorea fat and APLUS, which is mostly the same as Example 1, except that the component mass content is adjusted as follows to obtain sunscreen composition 5:

[0091] Wu-guan fruit oil 100;

[0092] APLUS 10.

[0093] Example 6

[0094] A sunscreen oil product based on Wu-guan fruit oil and APLUS, which includes the following components and weight contents:

[0095] Sunscreen composition 1 97.0%;

[0096] Shea butter 2.0%;

[0097] Di-tert-butyl-p-methylphenol 0.5%;

[0098] p-Hydroxyacetophenone 0.5%.

[0099] The preparation method is as follows:

[0100] A1: Prepare the components in the following mass ratio:

[0101] Sunscreen composition 1 97.0%;

[0102] Shea butter 2.0%;

[0103] Di-tert-butyl-p-methylphenol 0.5%;

[0104] p-Hydroxyacetophenone 0.5%.

[0105] A2: Mix sunscreen composition 1 and shea butter in the above ratio, heat in a water bath to 85°C, stir uniformly at 200 rpm, then cool to 55°C, add the above ratio of di-tert-butyl-p-methylphenol and p-hydroxyacetophenone, stop stirring when it reaches room temperature, discharge, and the target product, sunscreen oil product 1 based on Wu-guan fruit oil and APLUS, is obtained.

[0106] Example 7

[0107] A sunscreen oil product based on Wu-guan fruit oil and MC80, which includes the following components and weight contents:

[0108] Sunscreen composition 2 97.0%;

[0109] Shea butter 2.0%;

[0110] Di-tert-butyl-p-methylphenol 0.5%;

[0111] p-Hydroxyacetophenone 0.5%.

[0112] The preparation method is as follows:

[0113] A1: Prepare the components in the following mass ratio:

[0114] Sunscreen composition 2 97.0%;

[0115] Shea butter 2.0%;

[0116] Di-t-butyl p-methyl phenol 0.5%;

[0117] p-Hydroxyacetophenone 0.5%.

[0118] A2: Mix sunscreen composition 2, shea butter according to the above proportion, heat to 85℃ in water bath, stir uniformly at 200 rpm, then cool to 55℃, add the above proportion of di-t-butyl p-methyl phenol and p-hydroxyacetophenone, stop stirring when it reaches room temperature, discharge, and the target product sunscreen oil product 2 of Xingguan fruit oil and MC80 is obtained.

[0119] Example 8

[0120] A sunscreen oil product based on Xingguan fruit oil and benzophenone-3, the sunscreen oil comprising the following components and weight content:

[0121] Sunscreen composition 3 97.0%;

[0122] Shea butter 2.0%;

[0123] Di-t-butyl p-methyl phenol 0.5%;

[0124] p-Hydroxyacetophenone 0.5%.

[0125] The preparation method is as follows:

[0126] A1: Prepare the following components in the following mass proportions:

[0127] Sunscreen composition 3 97.0%;

[0128] Shea butter 2.0%;

[0129] Di-t-butyl p-methyl phenol 0.5%;

[0130] p-Hydroxyacetophenone 0.5%.

[0131] A2: Mix sunscreen composition 3, shea butter according to the above proportion, heat to 85℃ in water bath, stir uniformly at 200 rpm, then cool to 55℃, add the above proportion of di-t-butyl p-methyl phenol and p-hydroxyacetophenone, stop stirring when it reaches room temperature, discharge, and the target product sunscreen oil product 3 of Xingguan fruit oil and benzophenone-3 is obtained, see Figure 1 .

[0132] Example 9

[0133] A sunscreen oil product based on Xanthoceras sorbifolia oil and APLUS, most of which is the same as Example 6, except that the amounts of the sunscreen oil components are adjusted as follows, to obtain sunscreen oil product 4.

[0134] Sunscreen composition 1 94.0%;

[0135] Shea butter 5.0%;

[0136] Di-t-butyl-p-methyl phenol 0.5%;

[0137] p-Hydroxyacetophenone 0.5%.

[0138] Example 10

[0139] A sunscreen oil product based on Xanthoceras sorbifolia oil and APLUS, most of which is the same as Example 6, except that the amounts of the sunscreen oil components are adjusted as follows, to obtain sunscreen oil product 5.

[0140] Sunscreen composition 1 97.5%;

[0141] Shea butter 1.9%;

[0142] Di-t-butyl-p-methyl phenol 0.5%;

[0143] p-Hydroxyacetophenone 0.1%.

[0144] Example 11

[0145] A sunscreen oil product based on Xanthoceras sorbifolia oil and APLUS, most of which is the same as Example 6, except that the amounts of the sunscreen oil components are adjusted as follows, to obtain sunscreen oil product 6.

[0146] Sunscreen composition 1 97.5%;

[0147] Shea butter 1.5%;

[0148] Di-t-butyl-p-methyl phenol 0.5%;

[0149] p-Hydroxyacetophenone 0.5%.

[0150] Example 12

[0151] A sunscreen oil product based on Xanthoceras sorbifolia oil and MC80, most of which is the same as Example 9, except that the sunscreen composition 1 is adjusted to be sunscreen composition 2, to obtain sunscreen oil product 7.

[0152] Example 13

[0153] A sunscreen oil product based on Xanthoceras sorbifolia oil and MC80, most of which is identical to Example 10, except that sunscreen composition 1 is adjusted to sunscreen composition 2, resulting in sunscreen oil product 8.

[0154] Example 14

[0155] A sunscreen oil product based on Xanthoceras sorbifolia oil and MC80, most of which is identical to Example 11, except that sunscreen composition 1 is adjusted to sunscreen composition 2, resulting in sunscreen oil product 9.

[0156] Example 15

[0157] A sunscreen oil product based on Xanthoceras sorbifolia oil and benzophenone-3, most of which is identical to Example 9, except that sunscreen composition 1 is adjusted to sunscreen composition 3, resulting in sunscreen oil product 10.

[0158] Example 16

[0159] A sunscreen oil product based on Xanthoceras sorbifolia oil and benzophenone-3, most of which is identical to Example 10, except that sunscreen composition 1 is adjusted to sunscreen composition 3, resulting in sunscreen oil product 11.

[0160] Example 17

[0161] A sunscreen oil product based on Xanthoceras sorbifolia oil and benzophenone-3, most of which is identical to Example 11, except that sunscreen composition 1 is adjusted to sunscreen composition 3, resulting in sunscreen oil product 12.

[0162] Example 18

[0163] A W / O sunscreen cream product based on Xanthoceras sorbifolia oil and APLUS, the W / O sunscreen cream comprising the following components and weight parts content:

[0164] Sunscreen composition 1 22%;

[0165] Siliconized silica 3.0%;

[0166] Cyclo-methicone 3.0%;

[0167] Dimethicone 3.0%;

[0168] Cetyl PEG / PPG-10 / 1 dimethicone 2%;

[0169] Magnesium stearate 0.3%;

[0170] Glycerin 6.0%;

[0171] p-Hydroxyacetophenone 0.2%;

[0172] Xanthan gum 0.05%;

[0173] Sodium chloride 1.0%;

[0174] Deionized water 59.45%.

[0175] The preparation method is as follows:

[0176] B1: Prepare the following components in the following mass ratio:

[0177] Sunscreen composition 1 22%;

[0178] Silylated silica 3.0%;

[0179] Cyclo-methicone 3.0%;

[0180] Dimethicone 3.0%;

[0181] Cetyl polyglyceryl / polypropylene glycol-10 / 1 dimethicone 2%;

[0182] Magnesium stearate 0.3%;

[0183] Glycerin 6.0%;

[0184] p-Hydroxyacetophenone 0.2%;

[0185] Xanthan gum 0.05%;

[0186] Sodium chloride 1.0%;

[0187] Deionized water 59.45%.

[0188] B2: Mix the sunscreen composition 1, silylated silica, cyclo-methicone, dimethicone, cetyl polyglyceryl / polypropylene glycol-10 / 1 dimethicone, and magnesium stearate, heat to 85°C, and stir to dissolve until the system is uniform to obtain an oil phase.

[0189] B3: Dissolve the xanthan gum and sodium chloride in deionized water, and heat and stir in a water bath under the condition of controlling the stirring speed of the magnetic stirrer at 200 rpm to 85°C to obtain an aqueous phase.

[0190] B4: Under the condition of controlling the stirring speed of the magnetic stirrer at 500 rpm, add the aqueous phase obtained in step B3 to the oil phase obtained in step B2, and stir for 5 min under the condition of a water bath at 85°C until mixed uniformly; under the condition of stirring at a speed of 1300 rpm in a homogenizer, homogenize for 3 min; cool to 55°C to obtain a mixture.

[0191] B5: Pre-dissolve the p-hydroxyacetophenone at 55 °C, add to the mixture from step B4, stir to room temperature at 100 rpm on a magnetic stirrer, and discharge, to give the target product, W / O sunscreen product 1.

[0192] Example 19

[0193] A W / O sunscreen product based on Xanthoceras oil and APLUS, most of which is identical to Example 18, except that the W / O sunscreen component is adjusted as follows in mass parts, to give W / O sunscreen product 2.

[0194] Sunscreen composition 1 24%;

[0195] Siliconized silica 1.0%;

[0196] Cyclo-methicone 1.0%;

[0197] Dimethicone 2.0%;

[0198] Cetyl PEG / PPG-10 / 1 dimethicone 1.0%;

[0199] Magnesium stearate 0.3%;

[0200] Glycerin 5.0%;

[0201] p-Hydroxyacetophenone 0.1%;

[0202] Xanthan gum 0.2%;

[0203] Sodium chloride 0.5%;

[0204] Deionized water 64.9%.

[0205] Example 20

[0206] A W / O sunscreen product based on Xanthoceras oil and APLUS, most of which is identical to Example 18, except that the W / O sunscreen component is adjusted as follows in mass parts, to give W / O sunscreen product 3.

[0207] Sunscreen composition 1 11%;

[0208] Siliconized silica 4.0%;

[0209] Cyclo-methicone 4.0%;

[0210] Dimethicone 4.0%;

[0211] Cetyl PEG / PPG-10 / 1 dimethicone 1.5%;

[0212] Magnesium stearate 0.3%;

[0213] Glycerin 8.0%;

[0214] 4-Methoxyacetophenone 0.5%;

[0215] Xanthan gum 0.6%;

[0216] Sodium chloride 0.8%;

[0217] Deionized water 65.3%.

[0218] Example 21

[0219] A W / O sunscreen product based on Xanthoceras sorbifolia oil and MC80, most of which is identical to Example 18, except that sunscreen composition 1 is adjusted to sunscreen composition 2, resulting in W / O sunscreen product 4.

[0220] Example 22

[0221] A W / O sunscreen product based on Xanthoceras sorbifolia oil and MC80, most of which is identical to Example 19, except that sunscreen composition 1 is adjusted to sunscreen composition 2, resulting in W / O sunscreen product 5.

[0222] Example 23

[0223] A W / O sunscreen product based on Xanthoceras sorbifolia oil and MC80, most of which is identical to Example 20, except that sunscreen composition 1 is adjusted to sunscreen composition 2, resulting in W / O sunscreen product 6.

[0224] Example 24

[0225] A W / O sunscreen product based on Xanthoceras sorbifolia oil and Benzophenone-3, most of which is identical to Example 18, except that sunscreen composition 1 is adjusted to sunscreen composition 3, resulting in W / O sunscreen product 7.

[0226] Example 25

[0227] A W / O sunscreen product based on Xanthoceras sorbifolia oil and Benzophenone-3, most of which is identical to Example 19, except that sunscreen composition 1 is adjusted to sunscreen composition 3, resulting in W / O sunscreen product 8.

[0228] Example 26

[0229] A W / O sunscreen product based on Xanthoceras sorbifolia oil and Benzophenone-3, most of which is identical to Example 20, except that sunscreen composition 1 is adjusted to sunscreen composition 3, resulting in W / O sunscreen product 9.

[0230] Comparative Example 1

[0231] A sunscreen composition based on white oil and APLUS, most of which is identical to Example 1, except that the Xanthoceras oil is adjusted to white oil, resulting in sunscreen composition 6.

[0232] Comparative Example 2

[0233] A sunscreen composition based on white oil and MC80, most of which is identical to Example 2, except that the Xanthoceras oil is adjusted to white oil, resulting in sunscreen composition 7.

[0234] Comparative Example 3

[0235] A sunscreen composition based on white oil and Benzophenone-3, most of which is identical to Example 3, except that the Xanthoceras oil is adjusted to white oil, resulting in sunscreen composition 8.

[0236] Comparative Example 4

[0237] A sunscreen composition based on dimethicone and APLUS, most of which is identical to Example 1, except that the Xanthoceras oil is adjusted to dimethicone, resulting in sunscreen composition 9.

[0238] Comparative Example 5

[0239] A sunscreen composition based on dimethicone and MC80, most of which is identical to Example 2, except that the Xanthoceras oil is adjusted to dimethicone, resulting in sunscreen composition 10.

[0240] Comparative Example 6

[0241] A sunscreen composition based on dimethicone and Benzophenone-3, most of which is identical to Example 3, except that the Xanthoceras oil is adjusted to dimethicone, resulting in sunscreen composition 11.

[0242] Comparative Example 7

[0243] A sunscreen oil product based on white oil and APLUS, most of which is identical to Example 6, except that the sunscreen composition 1 is adjusted to sunscreen composition 6, resulting in sunscreen oil product 13.

[0244] Comparative Example 8

[0245] A sunscreen oil product based on white oil and MC80, most of which is identical to Example 6, except that the sunscreen composition 1 is adjusted to sunscreen composition 7, resulting in sunscreen oil product 14.

[0246] Comparative Example 9

[0247] A sunscreen oil product based on white oil and Benzophenone-3, most of which is identical to Example 6, except that the sunscreen composition 1 is adjusted to sunscreen composition 8, resulting in sunscreen oil product 15.

[0248] Comparative Example 10

[0249] A sunscreen oil product based on dimethicone and APLUS, most of which are the same as Example 6, except that sunscreen composition 1 is adjusted to sunscreen composition 9, to obtain sunscreen oil product 16.

[0250] Comparative Example 11

[0251] A sunscreen oil product based on dimethicone and MC80, most of which are the same as Example 6, except that sunscreen composition 1 is adjusted to sunscreen composition 10, to obtain sunscreen oil product 17.

[0252] Comparative Example 12

[0253] A sunscreen oil product based on dimethicone and benzophenone-3, most of which are the same as Example 6, except that sunscreen composition 1 is adjusted to sunscreen composition 11, to obtain sunscreen oil product 18.

[0254] Performance test of sunscreen oil product

[0255] I. SPF value and PA value

[0256] SPF value and PA value tests were performed on sunscreen oil products 1-3 obtained from Examples 6-8 and sunscreen oil products 13-18 obtained from Comparative Examples 7-12, Xiangguo oil, white oil, and dimethicone.

[0257] Test method: SPF meter method. The sample to be tested was evenly coated on a PMMA plate with an area of 25 cm 2 2 with a mass of 0.05+0.0005 g (2 mg / cm 2 2), and was placed in the dark for 30 minutes to dry. After preheating the instrument for 1 hour, the blank PMMA plate was used as a control, and the instrument was used to test the sample using different ultraviolet wavelengths. The SPF value and PA value of the sample were calculated by the WinSPF software provided with the system.

[0258] Test results: see Table 1.

[0259] Table 1. SPF value and PA value of different oils and sunscreen oil products

[0260]

[0261] Comparing the SPF and PA values ​​of the *Xanthoceras sorbifolium* oil, white oil, and dimethyl silicone oil, it can be assumed that the SPF and PA values ​​of the solid oils, antioxidants, and preservatives in the sunscreen product are negligible. Therefore, without the addition of the oil-soluble UV absorber, the SPF and PA values ​​of the *Xanthoceras sorbifolium* oil, white oil, or dimethyl silicone oil itself, after conversion based on dosage, are equivalent to the SPF and PA values ​​of the sunscreen product. Table 1 shows that compared to the two commonly used cosmetic oils, white oil and dimethyl silicone oil, the *Xanthoceras sorbifolium* oil has a better sun protection effect, with an SPF of 13.49 and a PA of 5.25. In contrast, the white oil has an SPF of only 1.55 and a PA of 2.04, and the dimethyl silicone oil has an SPF of only 1.78 and a PA of 1.41, with negligible sun protection effects.

[0262] The *Xanthoceras sorbifolium* oil, combined with equal amounts of three different oil-soluble UV absorbers—APLUS, MC80, and benzophenone-3—provides better UV protection. The SPF values ​​of sunscreen products 1-3 are 20.10, 34.44, and 39.29, respectively, and their PA values ​​are 81.83, 30.72, and 54.69, respectively, all significantly higher than sunscreen products 13-18 using white oil and dimethyl silicone oil. Furthermore, the SPF and PA values ​​of the sunscreen composition are higher than the sum of the SPF and PA values ​​of *Xanthoceras sorbifolium* oil alone and the corresponding sunscreen agents, exhibiting a synergistic effect. For example, while the white oil and benzophenone-3 have good solubility, the SPF value of the white oil itself is negligible. Measuring the SPF value of sunscreen product 15, which is based on sunscreen composition 8 using the white oil and benzophenone-3, can be considered as the SPF value contributed by benzophenone-3. As shown in Table 1, the SPF value of sunscreen product 15 is 15.76, and the SPF value of *Xanthoceras sorbifolium* oil is 13.49. The sum of their values ​​is less than the SPF value of sunscreen product 3, which is 39.29, achieved using sunscreen composition 3 based on *Xanthoceras sorbifolium* oil and benzophenone-3. Similarly, sunscreen product 1, using sunscreen composition 1 based on *Xanthoceras sorbifolium* oil and APLUS, has a better sun protection effect than the sum of APLUS and *Xanthoceras sorbifolium* oil, and sunscreen product 2, using sunscreen composition 2 based on *Xanthoceras sorbifolium* oil and MC80, has a better sun protection effect than the sum of MC80 and *Xanthoceras sorbifolium* oil, demonstrating a synergistic effect.

[0263] Meanwhile, the actual product images of sunscreen products 3, 15, and 18 are as follows: Figure 1As shown, the sunscreen oil product 3 containing the Xanthoceras sorbifolia Bunge oil and benzophenone-3 is uniform, while the sunscreen oil product 15 containing the white oil and benzophenone-3 and the sunscreen oil product 18 containing the dimethyl silicone oil and benzophenone-3 are not uniform and not dissolved. The measurement of the SPF value or the PA value of the sunscreen product first needs to ensure the uniformity of the product to avoid the occurrence of the window effect, which greatly reduces the SPF value and the PA value. This is one of the reasons why the combination of the white oil, the dimethyl silicone oil and benzophenone-3 has a poor sunscreen effect. Similarly, the combination of the white oil, the dimethyl silicone oil and APLUS and MC80 also has the problem of non-uniformity and non-dissolution, which also shows that the Xanthoceras sorbifolia Bunge oil has good compatibility with the oil-soluble ultraviolet absorber, can reduce the precipitation of the oil-soluble ultraviolet absorber in the sunscreen product, and improve the sunscreen effect.

[0264] II. Survival of nematodes and phagocytosis rate

[0265] The Xanthoceras sorbifolia Bunge oil, the white oil and the dimethyl silicone oil were subjected to the survival of nematodes and the phagocytosis rate test.

[0266] Test method: The Caenorhabditis elegans was used as a model, and the survival rate and the phagocytosis rate after irradiation for 24 hours were measured to evaluate the sunscreen performance of the sample. A certain amount of L4 stage Caenorhabditis elegans was selected and placed on the NGM plate, and the sample to be tested was coated on the cover of the culture dish (2 mg / cm 2 ). The culture medium was irradiated under the simulated sunlight xenon lamp light source, the ultraviolet meter was calibrated by the ultraviolet radiation meter, and the UVB (290-320 nm) radiation amount was 0.7 j / cm 2 . After irradiation for 24 hours, the survival of nematodes and the phagocytosis rate were observed under a microscope. The survival of nematodes and the phagocytosis rate without irradiation and without coating were set for comparison.

[0267] Test results: The survival rate of nematodes is also an important indicator for evaluating the physiological state of nematodes. As can be seen from Figure 2 , the survival rate of nematodes coated with the Xanthoceras sorbifolia Bunge oil is 55%, which is higher than that of the white oil and the dimethyl silicone oil. The survival rate of nematodes of the sunscreen oil product 3 containing the Xanthoceras sorbifolia Bunge oil and benzophenone-3 is 74%, which is higher than that of the sunscreen oil product 15 containing the white oil and benzophenone-3 and the sunscreen oil product 18 containing the dimethyl silicone oil. The survival rate of nematodes coated with the sunscreen oil product 3 containing the Xanthoceras sorbifolia Bunge oil and benzophenone-3 is also higher than that of nematodes coated with only the Xanthoceras sorbifolia Bunge oil. The survival rate of nematodes of the sunscreen oil product 3 containing the Xanthoceras sorbifolia Bunge oil and benzophenone-3 is increased by 22% compared with that without coating, which has a good ultraviolet protection effect.

[0268] Swallowing frequency reflects the vitality of the nematodes, as the worms age, the rate of the pharyngeal pump decreases and the swallowing movement will stop before the death of the worms. The swallowing rate will decrease under UV irradiation, which indicates that the radiation accelerates the aging process in the worms. This can be due to the degeneration of the muscles that help the pharyngeal movement of the worms, by Figure 3 It can be seen that the swallowing frequency of the nematode model of the sunscreen product 3 containing Xanthoceras sorbifolia Bunge oil and benzophenone-3 is the highest in all experiments, which is 96 times / min, which is 27 times / min higher than that without coating. Therefore, the sunscreen product 3 composed of Xanthoceras sorbifolia Bunge oil and benzophenone-3 will show better sunscreen properties and can effectively protect C. elegans from UV damage.

[0269] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. Those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without having to go through creative labor. Therefore, the present application is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art within the scope of the present application without departing from the scope of the present application should be within the scope of protection of the present application.

Claims

1. A sunscreen composition based on Xanthoceras sorbifolia oil and an oil-soluble ultraviolet absorber, characterized in that, The sunscreen composition comprises the following components and weight content: Xanthoceras sorbifolia Bunge oil 100; Oil-soluble ultraviolet absorber 1~10; The oil-soluble ultraviolet absorber is one or more of benzophenone-3, MC80, APLUS.

2. The method of preparing a sunscreen composition based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber according to claim 1, characterized by, Mixing, heating, dissolving and cooling the Xanthoceras sorbifolia Bunge oil and the oil-soluble ultraviolet absorber to obtain the sunscreen composition; The heating and dissolving temperature is 75~95℃; The cooling temperature is room temperature.

3. Use of a sunscreen composition based on Xanthoceras sorbifolia Bunge oil and an oil-soluble UV-absorbing agent according to claim 1, characterized in that, A sunscreen oil product and a W / O sunscreen cream product are prepared.

4. A sunscreen oil product based on Xanthoceras sorbifolia oil and an oil-soluble UV-absorbing agent, characterized in that, It comprises the sunscreen composition of claim 1, and the components and mass percentage content are as follows: Sunscreen composition 94.0%~97.5%; Solid oil 1.5%~5.0%; Antioxidant 0.5%; Preservative 0~0.5%.

5. The sunscreen oil product based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber according to claim 4, characterized by, The solid oil comprises one or more of shea butter, stearic acid, monoglyceride, cetylstearyl alcohol, behenyl alcohol; The antioxidant is di-t-butyl-p-methylphenol; The preservative comprises one or more of p-hydroxyacetophenone, nipagin, hydroxybenzoic acid ester.

6. A preparation method of a sunscreen oil product based on Xanthoceras sorbifolia Bunge oil and oil-soluble ultraviolet absorber according to claim 4, comprising the following steps: A1: Prepare the following components in the following mass proportions: Sunscreen composition 94.0%~97.5%, Solid oil 1.5%~5.0%, Antioxidant 0.5%, Preservative 0~0.5%; A2: Mix the sunscreen composition and the solid oil in the above proportions, heat in a water bath to 75~95℃, stir until uniform, then cool to 50~60℃, add the antioxidant and the preservative, stop stirring when the temperature reaches room temperature, and discharge the product, which is the target product sunscreen oil product.

7. A W / O sunscreen product based on Xanthoceras sorbifolia oil and an oil-soluble UV-absorber characterized in that, It comprises the sunscreen composition of claim 1, and the components and mass percentage content are as follows: Sunscreen composition 11%~24%; Liquid oil 4%~12%; Emulsifier 1.3%~2.3%; Moisturizer 5%~8%; Preservative 0~0.5%; Thickening agent 0.05%~0.6%; Sodium chloride 0.5%~1.0%; Water 51.6%~78.15%.

8. The W / O sunscreen product based on Xanthoceras sorbifolia oil and oil-soluble UV absorber according to claim 7, characterized in that, The liquid oil comprises one or more of polydimethylsiloxane, silylated silica, cyclomethicone; The emulsifier comprises one or more of cetyl polyethylene glycol / polypropylene glycol-10 / 1 dimethylsiloxane, cetylstearyl alcohol, cetyl dimethicone, magnesium stearate; The moisturizer comprises one or more of glycerol, polyethylene glycol, 1,3-butanediol; The preservative is one of p-hydroxyacetophenone, nipagin, hydroxybenzoic acid ester; The thickening agent comprises xanthan gum or carbomer.

9. A method for preparing a W / O sunscreen product based on Xanthoceras sorbifolia Bunge oil and oil-soluble UV absorbers according to claim 7, It comprises the following steps: B1: Prepare the following components in the following mass proportions: Sunscreen composition 11%~24%, Liquid oil 4%~12%, Emulsifier 1.3%~2.3%, Moisturizer 5%~8%, Preservative 0~0.5%, Thickening agent 0.05%~0.6%, Sodium chloride 0.5%~1.0%, Deionized water 51.6%~78.15%. B2: mix the sunscreen composition, liquid oil, emulsifier, heat to 75~95℃, stir until the system is uniform, to obtain an oil phase; B3: dissolve the thickening agent, humectant, sodium chloride in deionized water, heat to 75~95℃, stir, to obtain an aqueous phase; B4: stir the oil phase obtained in step B2, add the aqueous phase obtained in step B3 thereto, heat to 75~95℃, continue to stir until mixed uniformly, homogenize, cool to 50~60℃, to obtain a mixture; B5: add a preservative to the mixture obtained in step B4, stir to room temperature, discharge, to obtain the target product, a W / O sunscreen product.

Images