Eustachian tube drug delivery stent and delivery device

Abstract

This invention relates to a Eustachian tube drug-eluting stent and delivery device. The Eustachian tube drug-eluting stent includes an expandable stent body and an opening adjustment component connected to the stent body. The stent body is a tubular structure with an internal channel, and both its front and rear ends have openings. The opening adjustment component is positioned near the opening at the rear end. When the stent body is inflated, the opening adjustment component partially closes the channel. The stent body and opening adjustment component are compressed into a gripped state and delivered into the Eustachian tube. The stent body gradually expands within the Eustachian tube until its outer surface adheres to the inner wall of the Eustachian tube, allowing medication to be loaded onto the stent body for treatment of the Eustachian tube. The opening adjustment component is connected near the opening at the rear end of the stent body, partially obstructing the channel of the stent body and preventing the Eustachian tube from remaining completely open, thus reducing the occurrence of complications caused by the Eustachian tube being in an open state for an extended period.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a eustachian tube drug delivery stent and delivery device. Background Technology

[0002] The Eustachian tube connects the middle ear to the nasopharynx, located in the upper laryngeal region just above the palate behind the nose. It typically acts as an equalizing valve for the air-filled middle ear. When the Eustachian tube functions normally, it opens periodically (approximately every three minutes) for a fraction of a second in response to swallowing or yawning, allowing air to enter the middle ear to replace air already absorbed by the middle ear lining (mucosa) or to balance pressure changes that occur with altitude changes. Eustachian tube obstruction is a common clinical problem; any lesion that prevents the periodic opening and closing of the Eustachian tube can lead to hearing loss or other ear symptoms. Eustachian tube obstruction results in negative middle ear pressure, accompanied by the retraction of the eardrum (aspiration). In adults, this is often accompanied by some ear discomfort, a feeling of fullness or pressure, and can lead to mild hearing loss and head noise (tinnitus). If the obstruction is prolonged, fluid may be drawn from the middle ear mucosa, forming a condition called serous otitis media (middle ear fluid). This can occur frequently in children with upper respiratory tract infections and can cause hearing loss associated with this condition.

[0003] The conventional treatment for obstructive eustachian tube disease involves using a balloon dilation catheter. A balloon is delivered to the affected area via a pusher device to inflate and open the eustachian tube, after which the balloon is removed. This method can easily lead to eustachian tube tissue tearing and scarring. Clinically, patients often experience symptoms such as low-pitched tinnitus, ear fullness, ear pressure, ear pain, and hyperacusis. Summary of the Invention

[0004] Therefore, it is necessary to provide a eustachian tube drug-carrying stent and delivery device to address the problems that traditional treatments for eustachian tube obstruction can easily lead to eustachian tube tissue tearing and discomfort such as low-pitched tinnitus in patients.

[0005] A drug-eluting stent for the Eustachian tube includes an expandable stent body and an opening adjustment member connected to the stent body. The stent body is a tube with an internal channel. Both the front and rear ends of the stent body are provided with openings. The opening adjustment member is located near the opening at the rear end. When the stent body is in an expanded state, the opening adjustment member causes the channel to be partially closed.

[0006] The aforementioned Eustachian tube drug-eluting stent, when used, compresses the stent body and opening adjustment device into a gripping state and delivers it into the Eustachian tube. The stent body gradually expands inside the Eustachian tube until the outer surface of the stent body adheres to the inner wall of the Eustachian tube. Medications can then be loaded onto the stent body to treat the Eustachian tube. Since the Eustachian tube is normally closed and only opens during yawning, swallowing, etc., when the stent body is implanted in the Eustachian tube and is in an expanded state, it will cause the Eustachian tube to be in an open state. By connecting the opening adjustment device near the tail end of the stent body, the passage of the stent body is partially blocked, preventing the Eustachian tube from being completely open for extended periods. This reduces the occurrence of complications such as low-pitched tinnitus, ear fullness, ear pressure, ear pain, and hyperaural hearing caused by the Eustachian tube being in an open state for a long time.

[0007] In one embodiment, the opening adjustment member includes a plurality of barbs arranged along the circumferential direction of the channel. One end of each barb is rotatably connected to the tail end of the support body. When the support body is in an expanded state, the other ends of all the barbs converge to make the opening adjustment member open to partially block the channel, and a gap is left between adjacent barbs.

[0008] In one embodiment, the barbs are plate-shaped, and when the support body is in an expanded state, the angle between the barbs and the axial direction of the support body is 60°-110°.

[0009] In one embodiment, the barbs are fan-shaped or triangular, and the included angle of the end of the barb away from the support body is 15°-30°.

[0010] In one embodiment, the barbs are received within a channel of the support body;

[0011] And / or, the ends of all the barbs away from the support body are connected at the axis of the support body.

[0012] In one embodiment, the opening adjustment member includes a plurality of expansion bodies arranged along the circumferential direction of the channel. The expansion bodies are disposed on the inner wall of the support body. When the support body is in an expanded state, the expansion bodies are opened to cover part of the channel.

[0013] In one embodiment, the opening adjustment member includes an elastic thread located within the channel, which expands to partially block the channel when the support body is in an expanded state.

[0014] In one embodiment, the front end of the support body is cylindrical and the rear end of the support body is frustum-shaped.

[0015] And / or, the support body includes a plurality of pillars, which are woven together to form a plurality of diamond-shaped grids.

[0016] In one embodiment, both the stent body and the opening adjustment component are made of biodegradable materials, and the outer surface of the stent body is provided with a drug-loaded coating.

[0017] A delivery device includes a push rod and a conveyor, the conveyor having a delivery channel extending through its front end and a rear end, the delivery channel being used to load the Eustachian tube drug-loaded stent, and the push rod being placed within the delivery channel for pushing the rear end of the Eustachian tube drug-loaded stent.

[0018] In one embodiment, the conveying device further includes a conveying conduit connected to the tail end of the conveyor, and the push rod is located inside the conveying conduit;

[0019] And / or, the delivery device further includes a gripper and a pusher, the gripper having a gripping channel extending through its front and rear ends, the gripping channel for inserting the Eustachian tube drug-loaded stent, and the pusher being placed within the gripping channel to push the front end of the Eustachian tube drug-loaded stent so that the Eustachian tube drug-loaded stent enters the delivery channel.

[0020] In use, the aforementioned delivery device involves compressing one end of the Eustachian tube drug-eluting stent and inserting it into the delivery device. The stent is then gradually inserted, ensuring it is fully inside the device. At this point, the stent transitions from an inflated to a compressed state. The stent is then transported through the nasal cavity to the pharyngeal inlet by the delivery device. The push rod is then pushed into the Eustachian tube, where the stent gradually expands until its outer surface adheres to the inner wall of the tube. Medication can then be loaded onto the stent to treat the Eustachian tube. Treatment: Because the Eustachian tube is normally closed and only opens when yawning or swallowing, when the stent is implanted into the Eustachian tube and is in an expanded state, the Eustachian tube will be in an open state. By connecting an opening adjustment device near the tail end of the stent, the channel of the stent is partially blocked, preventing the Eustachian tube from being completely unobstructed. This reduces the occurrence of complications such as low-pitched tinnitus, ear fullness, ear pressure, ear pain, and excessive self-hearing caused by the Eustachian tube being in an open state for a long time. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural schematic diagram of a drug-eluting stent for the Eustachian tube according to an embodiment of this application;

[0022] Figures 2a-2d The conveying device according to an embodiment of this application will Figure 1 The diagram shows the process of installing a drug-eluting stent in the Eustachian tube.

[0023] Figure 3 This is a schematic diagram of the opening adjustment component of a drug-eluting stent for the eustachian tube according to an embodiment of this application;

[0024] Figure 4 This is a schematic diagram of the opening adjustment component of a drug-eluting stent for the eustachian tube according to an embodiment of this application;

[0025] Figure 5 This is a schematic diagram of the opening adjustment component of a drug-eluting stent for the eustachian tube according to an embodiment of this application;

[0026] Figure 6 This is a cross-sectional schematic diagram of a drug-eluting stent for the Eustachian tube according to another embodiment of this application;

[0027] Figure 7 This is a schematic diagram of a drug-eluting stent for the Eustachian tube according to another embodiment of this application.

[0028] Explanation of icon numbers:

[0029] 10. Eustachian tube drug-eluting stent; 110. Stent body; 101. Drug-eluting coating; 112. Channel; 114. Front end; 116. Tail end; 118. Support; 119. Diamond mesh; 120. Opening adjustment element; 122. Barbs; 124. Expander; 126. Thread;

[0030] 30. Push rod; 40. Conveyor; 410. Conveying channel; 50. Pusher; 60. Presser; 610. Presser channel; 70. Conveying conduit;

[0031] 80. Eustachian tube. Detailed Implementation

[0032] To make the above-mentioned objects, features, and advantages of the present invention more apparent and understandable, specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of the present invention. However, the present invention can be practiced in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0033] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0034] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0035] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0036] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "over," and "on top" of the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0037] It should be noted that when an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0038] Reference Figure 1 One embodiment of this application provides a Eustachian tube drug-loaded stent 10, including an expandable stent body 110 and an opening adjustment member 120 connected to the stent body 110. The stent body 110 is a tube with an internal channel 112. The front end 114 and the rear end 116 of the stent body 110 are both provided with openings. The opening adjustment member 120 is disposed near the opening of the rear end 116. When the stent body 110 is in an expanded state, the opening adjustment member 120 causes the channel 112 to be partially closed.

[0039] The front end 114 and the tail end 116 are based on the direction of movement of the Eustachian tube drug-loaded stent 10 when it is placed from outside the body into the Eustachian tube 80. The part that enters the Eustachian tube 80 first is the front end 114, and the part that enters the Eustachian tube 80 later is the tail end 116.

[0040] The Eustachian tube drug-loaded stent 10 is an elastic structural component that can expand into an expanded state by its own material properties in a natural state, and can be compressed into a compressed state under the action of external force.

[0041] In use, the aforementioned Eustachian tube drug-eluting stent 10 is compressed into a gripping state by the stent body 110 and the opening adjustment component 120 and delivered into the Eustachian tube 80. The stent body 110 gradually expands within the Eustachian tube 80 until the outer surface of the stent body 110 adheres to the inner wall of the Eustachian tube 80. Medication can then be loaded onto the stent body 110 to treat the Eustachian tube 80. Since the Eustachian tube 80 is normally closed and only opens during yawning or swallowing, the expanded state of the stent body 110 would cause the Eustachian tube 80 to be in an open state. However, by connecting the opening adjustment component 120 near the opening of the stent body 110 at its tail end 116, the channel 112 of the stent body 110 is partially blocked, while remaining partially open. This prevents the Eustachian tube 80 from being completely unobstructed, reducing the risk of complications such as low-pitched tinnitus, ear fullness, ear pressure, ear pain, and hyperacusis caused by the Eustachian tube 80 remaining open for extended periods.

[0042] Reference Figure 1In one embodiment, the support body 110 is woven and includes multiple supports 118, which are woven to form multiple diamond-shaped meshes 119. The support body 110 is formed by repeatedly tightly connecting the multiple supports 118 one to another, thereby forming a tubular structure with multiple diamond-shaped meshes 119, making it elastic, compressible, and self-expanding. In other embodiments, the support body 110 can also be made into other shapes, such as meshes with circular, triangular, or rectangular shapes, to meet its compressibility and expandability requirements.

[0043] Reference Figure 1 and Figure 2d Furthermore, in one embodiment, the front end 114 of the stent body 110 is cylindrical. The rear end 116 of the stent body 110 is frustoconical, meaning the diameter of the rear end 116 is slightly larger than the diameter of the front end 114. The shapes of the front end 114 and the rear end 116 of the stent body 110 match the shape of the Eustachian tube 80, allowing them to adhere tightly to the inner wall of the Eustachian tube 80 after expansion. The opening adjustment member 120 located at the rear end 116 of the stent body 110 is also compressed under external pressure, facilitating delivery to the Eustachian tube 80.

[0044] In one embodiment, the outer surface of the stent body 110 is provided with a drug-loaded coating 101. As the stent body 110 expands within the Eustachian tube 80, the outer surface of the stent body 110 adheres to the inner wall of the Eustachian tube 80. The drug-loaded coating 101 is disposed on the outer surface of the stent body 110. The drug (such as steroids, anti-inflammatory drugs, antibiotics, etc.) carried on the drug-loaded coating 101 on its outer surface adheres to the inner wall of the Eustachian tube 80 and expands the Eustachian tube 80. The drug is automatically released in the body to treat the Eustachian tube 80 obstruction. The drug release cycle can be set to 1-3 weeks to achieve continuous drug delivery, realize precise and continuous drug delivery, and treat the Eustachian tube 80 obstruction.

[0045] In one embodiment, both the stent body 110 and the opening adjustment component 120 are made of biodegradable materials, avoiding the need for surgical removal and thus preventing patient suffering. The Eustachian tube drug-eluting stent 10 is made of biodegradable materials, including but not limited to the following biodegradable polymers: polylactic acid (PLA), L-polylactic acid (PLLA or LPLA), polyglycolic acid / polylactic acid copolymer (PGLA), chitosan, PVA, and copolymers or blends of the above materials, and their homologues. It is formed by manual or machine carving or hollowing, or by direct molding, and finally formed through a heat-setting process. The degradation time is selected based on the material ratio, ranging from 4 to 6 weeks, and it degrades into water and carbon dioxide after the Eustachian tube 80 has healed.

[0046] Reference Figure 1 In one embodiment, the opening adjustment member 120 includes a plurality of barbs 122 arranged circumferentially along the channel 112. One end of each barb 122 is rotatably connected to the tail end 116 of the support body 110. When the support body 110 is in an expanded state, one end of all the barbs 122 rotates accordingly, causing their other ends to converge, thereby making the opening adjustment member as a whole open to block part of the channel 112, with gaps between adjacent barbs 122. The barbs 122 themselves block part of the channel 112 of the support body 110, while the gaps between the barbs 122 allow part of the channel 112 to remain open, preventing the channel 112 from always being in a completely open state. (See reference...) Figure 3 , 4 5. The number and size of the barbs 122 can be adaptively adjusted according to the patient's reaction to see if they feel discomfort, in order to meet the needs of different patients and reduce their pain. The barbs 122 can be woven or machined integrally with the support.

[0047] In one embodiment, the barbs 122 are plate-shaped so that they can block the channel 112 to a certain extent after being squeezed and expanded. Optionally, when the support body 110 is in an expanded state, the angle α between the barbs 122 and the axial direction of the support body 110 is 60°-110°. Figure 2d This is a schematic diagram of the Eustachian tube drug-loaded stent 10 in its expanded state within the Eustachian tube 80. During the expansion of the stent body 110, the end of the barb 122 furthest from the axis of the stent body 110 rotates relative to the stent body 110. The angle α between the barb 122 and the axis of the stent body 110 gradually increases until the stent body 110 completes its expansion. At this point, the angle α between the barb 122 and the axis of the stent body 110 remains stable, ranging from 60° to 110°, preferably 90°.

[0048] Alternatively, in one embodiment, the barbs 122 are received within the channel 112 of the support body 110. Please refer to [the document for further details]. Figure 2b and 2d ,in Figure 2b The diagram shows the Eustachian tube drug-loaded stent 10 in a compressed state. Figure 2d The diagram shows the Eustachian tube 80 in an expanded state. The barbs 122 are housed within the channel 112 in both the compressed and expanded states. In other embodiments, the barbs 122 may protrude from the channel 112.

[0049] Reference Figure 3 , 4 5. Optionally, in one embodiment, the barbs 122 are fan-shaped or triangular. Figure 3 , 4The barbs 122 shown are in the shape of a fan, with the end furthest from the support body 110 being the center of the fan. Figure 5 The barb 122 shown is a plate-shaped triangle, with the end furthest from the support body 110 being the vertex of the triangle. Optionally, in one embodiment, the included angle b of the end of the barb 122 furthest from the support body 110 is 15°-30°. By adjusting the included angle b, the size of the barb 122 can be adjusted, thereby adjusting the passage area of ​​the channel 112.

[0050] Optionally, in one embodiment, the ends of each barb 122 away from the support body 110 are connected at the axis of the support body 110. That is, the ends of each barb 122 away from the support body 110 are connected as a whole, forming an umbrella-like skeletal structure that closes as the support body 110 is compressed and expands as the support body 110 expands. In other embodiments, the ends of each barb 122 away from the support body 110 are free ends, which are compressed as the support body 110 is compressed and rotated and unfolded as the support body 110 expands.

[0051] Reference Figure 6 In another embodiment, the opening adjustment member 120 includes a plurality of expansion bodies 124 arranged circumferentially along the channel 112. The expansion bodies 124 are disposed on the inner wall of the support body 110. When the support body 110 is in an expanded state, the expansion bodies 124 expand to partially block the channel 112. When the support body 110 is in a compressed state, the expansion bodies 124 are squeezed and contracted within the channel 112. When the support body 110 is in an expanded state, they expand within the channel 112 to partially block the passage of the channel 112, preventing the Eustachian tube 80 from being in a completely open state for a long time and reducing patient discomfort. The expansion bodies 124 can be woven or processed into the channel 112 by other processes, or integrally woven or processed with the support body 110. The expansion bodies 124 can also be made of biodegradable materials and degrade on their own after treatment. The size and number of expansion bodies 124 can be adjusted according to the patient's tolerance to adjust the passage area of ​​the channel 112. The expansion bodies 124 can be configured as spherical structures with a mesh.

[0052] Reference Figure 7In another embodiment, the opening adjustment element 120 includes an elastic thread 126, which is wound around the stent body 110 along its axial direction. When the stent body 110 is in an expanded state, the thread 126 expands to partially block the channel 112. The elastic thread 126 is used as the opening adjustment element 120, and at least a portion of the thread 126 is located at the opening of the tail end 116 of the stent body 110. During compression of the stent body 110, the thread 126 is also compressed, causing the Eustachian tube drug-eluting stent 10 to reach a contracted state. During expansion of the stent body 110, the thread 126 expands accordingly to partially block the passage of the channel 112, preventing the Eustachian tube 80 from remaining completely open for extended periods and reducing patient discomfort. The thread 126 can be woven or processed into the channel 112, or integrally woven or processed with the stent body 110. The thread 126 can also be made of biodegradable materials and degrade automatically after treatment. The density of the thread 126 and the passage area of ​​the channel 112 can be adjusted according to the patient's tolerance.

[0053] Because the Eustachian tube 80 is relatively small, the Eustachian tube drug-eluting stent 10 cannot be directly implanted into the Eustachian tube 80. Therefore, a delivery device is needed to deliver the Eustachian tube drug-eluting stent 10 to the Eustachian tube 80. Therefore, referring to Figures 2a-2d This application also provides a delivery device in one embodiment, including a push rod 30 and a delivery device 40. The delivery device 40 has a delivery channel 410 extending through its front end 114 and its rear end 116. The delivery channel 410 is used to load the Eustachian tube drug-loaded stent 10 of any of the above embodiments. The push rod 30 is placed in the delivery channel 410 and is used to push the rear end 116 of the Eustachian tube drug-loaded stent 10.

[0054] In use, one end of the Eustachian tube drug-loaded stent 10 is compressed and inserted into the delivery device 40. The stent 10 is then gradually inserted until it is fully inserted into the delivery device 40. At this point, the stent 10 changes from an expanded state to a compressed state. The stent 10 is then delivered through the nasal cavity to the pharyngeal opening via the delivery device 40. The push rod 30 is then pushed into the Eustachian tube 80. The stent body 110 gradually expands within the Eustachian tube 80 until its outer surface adheres to the inner wall of the Eustachian tube 80. The medication on the stent body 110 is then used to treat the Eustachian tube 80. The eustachian tube 80 is normally closed and only opens when yawning or swallowing. When the stent body 110 is implanted into the eustachian tube 80 and is in an expanded state, the eustachian tube 80 will be in an open state. By connecting the opening adjustment component 120 to the opening position of the stent body 110 near its tail end 116, the channel 112 of the stent body 110 is partially blocked, thus preventing the eustachian tube 80 from being completely unobstructed. This reduces the occurrence of complications such as low-pitched tinnitus, ear fullness, ear pressure, ear pain, and excessive self-hearing caused by the eustachian tube 80 being in an open state for a long time in traditional treatment methods.

[0055] Furthermore, in one embodiment, the delivery device further includes a delivery conduit 70, which is connected to the tail end 116 of the delivery device 40, and a push rod 30 is located inside the delivery conduit 70. The delivery conduit 70 provides guidance, facilitating the delivery device's entry through the nostril. Upon reaching the pharynx, the push rod 30 gradually delivers the Eustachian tube drug-loaded stent 10 from its front end 114 to its tail end 116 into the Eustachian tube 80.

[0056] Furthermore, the delivery device also includes a gripper 60 and a pusher 50. The gripper 60 has a gripping channel 610 extending through its front end 114 and rear end 116. The gripping channel 610 is used to insert the Eustachian tube drug-loaded stent 10. The pusher 50 is placed inside the gripping channel 610 to push the front end 114 of the Eustachian tube drug-loaded stent 10 into the delivery channel 410. Since the Eustachian tube drug-loaded stent 10 is large in its expanded state and difficult to insert into the delivery channel 410, the gripper pre-compresses the Eustachian tube 80 into a gripped state before the pusher 50 pushes it into the delivery channel 410.

[0057] This embodiment takes the Eustachian tube drug-carrying stent 10, which includes a plurality of barbs 122 in the opening adjustment component 120, as an example to describe in detail the delivery process of the Eustachian tube drug-carrying stent 10:

[0058] Step 1, refer to Figure 2aDuring the surgical procedure, since the Eustachian tube drug-eluting stent 10 is in an inflated state by default, external force is needed to compress the stent 10 and place it into the gripper 60, which is then pushed into the delivery device 40 by the pusher 50; see reference. Figure 2b At this time, the Eustachian tube drug-carrying stent 10 is pressed into the delivery channel 410 of the delivery device 40. At this time, the barbs 122 are squeezed and contained in the tail end 116 of the channel 112.

[0059] Step two, refer to Figure 2c With the aid of an endoscope and guided by a delivery catheter 70, the doctor inserts a delivery device 40 carrying a Eustachian tube drug-eluting stent 10 through the nostril. The stent 10 is then delivered through the nasal cavity to the pharyngeal inlet by the delivery device 40, and then pushed into the Eustachian tube 80 by a pusher rod 30. Because the Eustachian tube drug-eluting stent 10 is implanted in a compressed state, it will self-open upon delivery into the Eustachian tube 80. (Refer to...) Figure 2d At this point, the Eustachian tube drug-loaded stent 10 has expanded. Under the mutual compression of the support column 118 and the inner wall of the Eustachian tube 80, the stent body 110 is tightly attached to the inner wall of the Eustachian tube 80, and the drug loaded in the drug-loaded coating 101 continuously delivers medication to the Eustachian tube 80 for treatment. At this time, all the barbs 122 are in an open state, so that the stent body 110 is in a partially open state, avoiding the Eustachian tube 80 being in an open state when the Eustachian tube drug-loaded stent 10 is implanted in the human body.

[0060] Similarly, the above method can also be used to... Figure 6 , Figure 7 The shown Eustachian tube drug-loaded stent 10 is installed in the Eustachian tube 80 to achieve Eustachian tube 80 treatment.

[0061] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0062] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A drug-eluting stent for the Eustachian tube, characterized in that, The device includes an expandable support body and an opening adjustment member connected to the support body. The support body is a tubular structure with an internal channel. Both the front and rear ends of the support body are provided with openings. The opening adjustment member is located near the opening at the rear end. When the support body is in an expanded state, the opening adjustment member causes the channel to be partially closed. The opening adjustment component includes multiple barbs arranged circumferentially along the channel. One end of each barb is rotatably connected to the tail end of the support body. When the support body is in an expanded state, the other ends of all the barbs converge, causing the opening adjustment component to open and partially block the channel, with gaps between adjacent barbs; or... The opening adjustment component includes a plurality of expansion bodies arranged along the circumferential direction of the channel. These expansion bodies are disposed on the inner wall of the support body. When the support body is in an expanded state, the expansion bodies open to partially block the channel; or... The opening adjustment component includes an elastic thread located within the channel. When the support body is in an expanded state, the thread expands to partially block the channel.

2. The Eustachian tube drug-eluting stent according to claim 1, characterized in that, The barbs are plate-shaped, and when the support body is in an expanded state, the angle between the barbs and the axial direction of the support body is 60°-110°.

3. The Eustachian tube drug-eluting stent according to claim 2, characterized in that, The barbs are fan-shaped or triangular, and the included angle of the end of the barb away from the support body is 15°-30°.

4. The Eustachian tube drug-eluting stent according to claim 3, characterized in that, The barbs are housed within the channel of the support body; And / or, the ends of all the barbs away from the support body are connected at the axis of the support body.

5. The Eustachian tube drug-eluting stent according to any one of claims 1-4, characterized in that, The front end of the support body is cylindrical, and the rear end of the support body is frustum-shaped. And / or, the support body includes a plurality of pillars, which are woven together to form a plurality of diamond-shaped grids.

6. The Eustachian tube drug-eluting stent according to any one of claims 1-4, characterized in that, Both the stent body and the opening adjustment component are made of biodegradable materials, and the outer surface of the stent body is provided with a drug-loaded coating.

7. A conveying device, characterized in that, The device includes a push rod and a conveyor, the conveyor having a conveying channel extending through its front and rear ends, the conveying channel being used to load the Eustachian tube drug-loaded stent according to any one of claims 1-6, the push rod being placed within the conveying channel for pushing the rear end of the Eustachian tube drug-loaded stent.

8. The conveying device according to claim 7, characterized in that, The conveying device further includes a conveying conduit connected to the tail end of the conveyor, and the push rod is located inside the conveying conduit; And / or, the delivery device further includes a gripper and a pusher, the gripper having a gripping channel extending through its front and rear ends, the gripping channel being used to insert the Eustachian tube drug-loaded stent according to any one of claims 1-6, and the pusher being placed in the gripping channel to push the front end of the Eustachian tube drug-loaded stent so that the Eustachian tube drug-loaded stent enters the delivery channel.

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