A multi-effect synergistic oral whitening composition and its application

Abstract

The present invention relates to the field of oral care and discloses a multi-effect synergistic oral whitening composition and its use. The oral whitening composition comprises: 3-80% methyl vinyl ether / maleic anhydride copolymer, 3-70% sodium monofluorophosphate, and 10-95% phosphate. The mass ratio of the methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate, and phosphate is 1:(0.2-7.5):(0.2-40). The molar ratio of methyl vinyl ether to maleic anhydride in the methyl vinyl ether / maleic anhydride copolymer ranges from 2:1 to 1:2, and the molecular weight ranges from 800,000 to 3,000,000. The present invention combines the methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate, and phosphate in specific proportions and types to produce a multi-effect synergistic effect in terms of rapid whitening, long-lasting prevention of tooth staining, and prevention of dental calculus.

Description

Technical Field

[0001] The present invention relates to the field of oral care, and in particular to a multi-effect synergistic oral whitening composition and application thereof. Background Art

[0002] As people's material and cultural living standards improve, their attention and pursuit of dental beauty are also increasing year by year. White teeth can increase self-confidence and play an increasingly important role in life and work. Common teeth whitening products include oral care products (such as toothpaste, tooth powder, mouthwash, etc.), whitening tooth strips, whitening gel and cold light whitening devices. Among them, whitening toothpaste is the most common daily oral care product. According to statistics from the China Oral Cleaning and Care Products Industry Association, the market share of whitening toothpaste in 2022 reached 23.07%, which shows that consumers have a great demand for whitening toothpaste.

[0003] Currently, the commonly used ingredients for whitening or removing tartar are: (1) abrasives, which are used to clean tooth stains through physical brushing and are essential ingredients in toothpaste, such as hydrated silica, calcium carbonate, dihydrated calcium hydrogen phosphate, etc.; (2) chemical agents, which can remove tooth stains through chelation, decomposition, bleaching and other forms, such as surfactants, peroxides, enzymes, citrates, pyrophosphates and hexametaphosphates; (3) light path modifiers, which mainly improve the whiteness of teeth by attaching blue dyes and mixing the blue light generated with the yellow light of the teeth.

[0004] The whitening effect of physical brushing alone is limited, and too high a friction value may cause damage to the tooth enamel. Among chemical preparations, phosphates are easily decomposed by alkaline phosphatase in saliva, resulting in a decrease in their effective activity. When enzyme preparations are used as effective ingredients, such as patent CN101264046 "An enzyme-containing toothpaste and its preparation method", by compounding multiple enzyme preparations, glucose and protein substances attached to the teeth are removed to prevent bacterial growth, thereby whitening the teeth; but the surfactants in the toothpaste will lead to poor enzyme stability, and the enzyme preparations also have high requirements for the production process temperature and storage conditions. When peroxide is used as a whitening effect, such as patent CN113995686B "An oral care composition with whitening function", hydrogen peroxide complex is used as a bleaching agent to achieve a whitening effect, but peroxide is highly irritating and can easily damage tooth enamel and even cause tooth sensitivity. In addition, peroxide has poor stability when added to toothpaste and is easy to decompose. At the same time, it may cause water leakage from the paste, flatulence and other problems. Optical whitening toothpaste makes teeth appear whiter by changing the light transmission properties of the tooth surface, but it does not cure the root cause and cannot effectively remove tooth stains. Summary of the Invention

[0005] To address the above technical problems, the present invention provides a multi-effect synergistic oral whitening composition and its use. The composition comprises a methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate, and a phosphate in specific ratios. These three components produce a significant synergistic effect, rapidly removing exogenous stains and providing long-term protection against tooth staining and tartar.

[0006] The specific technical solutions of the present invention are:

[0007] In a first aspect, the present invention provides a multi-effect synergistic oral whitening composition, comprising the following components in mass percentage: 3-80% (preferably 3-70%, more preferably 3-50%) of methyl vinyl ether / maleic anhydride copolymer, 3-70% (preferably 5-60%, more preferably 8-40%) of sodium monofluorophosphate, and 10-95% (preferably 15-90%, more preferably 20-80%) of phosphate.

[0008] The present invention has found that compounding methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate and phosphate can produce multiple synergistic effects in terms of rapid whitening, long-term prevention of tooth staining and prevention of dental calculus, specifically:

[0009] As discovered by the applicant in patent "2023110707249, a tooth whitening care composition safe for tooth enamel and its application" (the applicant's prior application, not prior art), the combination of sodium monofluorophosphate and phosphate has the following synergistic effects:

[0010] It is known that the fluoride ions in sodium monofluorophosphate can replace the OH- in hydroxyapatite, the main component of tooth enamel, to form fluorapatite, thereby being incorporated into tooth enamel to make the lattice more dense and reduce the solubility of tooth enamel to achieve the effect of strengthening tooth enamel. In addition, phosphate can adhere to the surface of the stain, interlacing with each other on the surface of the stain to present a similar network morphology. At this time, the PO group in the phosphate molecule can convert the colored group into a soluble complex through complexation with the inorganic chromophore in the stain, thereby dissolving and softening the tooth stain. Therefore, phosphate and sodium monofluorophosphate are known raw materials for tooth whitening care products. The present invention finds that due to intermolecular forces, the network morphology formed by phosphate has certain gaps, so the stain removal effect of a single phosphate is not ideal. For this reason, the present invention creatively selects sodium monofluorophosphate and phosphate to be compounded. The molecule of sodium monofluorophosphate is relatively small, which can make up for the gaps in the network structure formed by phosphate, making the network morphology more compact, thereby enhancing the whitening and stain removal effect. The present invention also discovered that small-molecule sodium monofluorophosphate more easily penetrates the interior of exogenous stains, combining with phosphates on the surface of the stains to form a strong complexation with a tight network morphology, thus disintegrating the stains from the inside out. Furthermore, phosphates and sodium monofluorophosphate can also be preferentially adsorbed on the tooth surface, effectively competing with chromophores for adsorption sites, thereby reducing the attachment of chromophores and forming the same tight network morphology on the tooth surface, effectively isolating pigment deposition and achieving a long-lasting effect against pigment deposition. Therefore, the combined use of sodium monofluorophosphate and phosphates has a significant synergistic effect, which can significantly enhance the stain removal effect and the effect of resisting pigment deposition.

[0011] In subsequent studies, the present inventors further discovered that the addition of methyl vinyl ether / maleic anhydride copolymer (PVM / MA copolymer) to this basis can further enhance the above-mentioned synergistic effect, achieving better and faster removal of exogenous stains and long-term prevention of tooth staining and tartar. Specifically, a large amount of plaque at the junction of the gums and teeth encounters calcium deposits in saliva, which gradually hardens to form tartar. Tartar can combine with inorganic chromatophores produced by foods and beverages containing pigments or during smoking to produce other colors inconsistent with teeth, such as yellow, brown, or black. Pyrophosphates and polyphosphates are recognized inhibitors of tartar, but their activity is affected by the decomposition of alkaline phosphatase in saliva. We found that adding an appropriate amount of methyl vinyl ether / maleic anhydride copolymer to the composition can play the following roles: ① The PVM / MA copolymer can chelate the metal ions at the active site of the phosphatase in saliva to inhibit the activity of the enzyme, thereby increasing the activity of phosphate; ② The surface of the PVM / MA copolymer has a negative charge, which has a certain charge repulsion effect with the similarly negatively charged phosphate, thereby better distributing the phosphate in the mouth and exerting its effect. Therefore, further compounding PVM / MA copolymer on the basis of sodium monofluorophosphate and phosphate can further significantly enhance the effect of tooth whitening and inhibiting tartar.

[0012] Preferably, the mass ratio of the methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate and phosphate is 1:(0.2-7.5):(0.2-40), preferably 1:(0.2-6):(0.2-30), and more preferably 1:(0.4-2.5):(1-10).

[0013] It should be emphasized that not all proportions of methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate, and phosphate can produce significant synergistic effects. When the relative content of methyl vinyl ether / maleic anhydride copolymer in the composition is low, it is difficult to effectively spread and cover the oral cavity, reducing the effectiveness of inhibiting enzyme activity and the interaction between the copolymer and phosphate, thereby reducing the efficacy of the composition. When the relative content of methyl vinyl ether / maleic anhydride copolymer in the composition is high, the paste is prone to water leakage and granulation. At the same time, when the relative content of phosphate in the composition is low, it will be difficult for the phosphate to form a network morphology on the surface of the stain. When the relative content of phosphate in the composition is too high, its large presence on the surface of the stain forms a multi-layered, interlaced network morphology, which is not conducive to the penetration of sodium monofluorophosphate into the gaps and the interior of the stain. At the same time, due to the limited solubility of phosphate, if used in toothpaste, excessive phosphate content will result in obvious particles in the paste, which will also destroy the viscosity-enhancing system in the paste and lead to stability issues such as water leakage. Therefore, the ratio of methyl vinyl ether / maleic anhydride copolymer to sodium monofluorophosphate / phosphate needs to be controlled within a reasonable range.

[0014] Preferably, the molar ratio of methyl vinyl ether to maleic anhydride in the methyl vinyl ether / maleic anhydride copolymer is in the range of 2:1 to 1:2, more preferably (0.8 to 1.2):1, and the molecular weight is in the range of 800,000 to 3,000,000, more preferably 1,000,000 to 1,800,000.

[0015] The macromolecular structure of the PVM / MA copolymer provides numerous adhesion sites. When combined with phosphates and sodium monofluorophosphate, it effectively spreads across the tooth surface, preventing pigment deposition on the tooth surface, increasing the retention of active ingredients in the oral cavity, and improving their bioavailability. The present invention further discovered that the molecular weight of the copolymer directly influences these effects. If the molecular weight is too low, its dispersibility is poor; increasing the molecular weight improves its dispersibility. However, if the molecular weight is too high, bridging can occur, causing flocculation and hindering dispersion. Furthermore, excessively high molecular weights reduce the chelating value per unit weight of the polymer due to steric hindrance. Therefore, the molecular weight of the polymer must be appropriate, and the present invention ultimately prefers the above molecular weight range.

[0016] Preferably, the phosphate is a compound of one or more of tripolyphosphate, pyrophosphate, hexametaphosphate and sodium phytate; further preferably, the phosphate is a phosphate with a chain structure; most preferably, the phosphate with a chain structure is a compound of one or more of sodium tripolyphosphate and sodium pyrophosphate.

[0017] Further, the present invention has also accidentally found in research that, compared with the phosphate (such as sodium phytate, sodium hexametaphosphate) with cyclic structure, the synergistic effect after the phosphate with chain structure and sodium monofluorophosphate is compounded is more remarkable. The reason is that the chain structure molecule is easier to fit the stain and thus plays a role, and the intermolecular force of the cyclic form phosphate is larger in addition, and the space between molecules is also more, so they are poor in compounding effect with sodium monofluorophosphate. We also find that, in terms of compounding effect with PVM / MA copolymer, compared to cyclic molecular structure phosphate, linear molecular structure phosphate is more susceptible to the charge repulsion of PVM / MA copolymer, so that it can be better distributed in the oral cavity and lasts for a long time. Further, cyclic molecular structure phosphate is more easily hydrolyzed or thermally decomposed in the product, thereby causing the active matter content to decline in the product. Therefore, the phosphate with chain structure is preferably

[0018] In a second aspect, the present invention provides a use of the oral whitening composition in an oral care product, wherein the oral whitening composition accounts for 1 to 15% by mass of the oral care product, preferably 2 to 10%, and more preferably 2 to 8.5%.

[0019] In a third aspect, the present invention provides an oral care product comprising 1 to 15% of the oral whitening composition, preferably 2 to 10%, and more preferably 2 to 8.5%.

[0020] Preferably, the pH of the oral care product is 6 to 8, more preferably 6.5 to 7.5.

[0021] The present invention found that the spreading performance of the PVM / MA copolymer is greatly affected by pH, so the pH of the oral care product matrix to which it is applicable needs to be controlled at 6 to 8, more preferably 6.5 to 7.5.

[0022] Preferably, the oral care product is toothpaste, tooth powder, tooth strips, mouthwash, spray, mousse, gel or aerosol.

[0023] Compared with the prior art, the present invention has the following technical effects: the present invention has discovered that by compounding sodium monofluorophosphate, phosphate and methyl vinyl ether / maleic anhydride copolymer in specific proportions and specific types, the three can produce a significant synergistic effect, which can achieve the effect of quickly removing exogenous stains and long-term preventing tooth staining and tartar. DETAILED DESCRIPTION

[0024] The present invention will be further described below with reference to the embodiments.

[0025] Overall embodiment

[0026] A multi-effect synergistic oral whitening composition comprises the following components in percentage by weight: 3-80% methyl vinyl ether / maleic anhydride copolymer, 3-70% sodium monofluorophosphate, and 10-95% phosphate. Preferably, the composition comprises 3-70% methyl vinyl ether / maleic anhydride copolymer, 5-60% sodium monofluorophosphate, and 15-90% phosphate. More preferably, the composition comprises 3-50% methyl vinyl ether / maleic anhydride copolymer, 8-40% sodium monofluorophosphate, and 20-80% phosphate.

[0027] Wherein: the mass ratio of the methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate and phosphate is 1:(0.2-7.5):(0.2-40), preferably 1:(0.2-6):(0.2-30) and more preferably 1:(0.4-2.5):(1-10).

[0028] In the methyl vinyl ether / maleic anhydride copolymer, the molar ratio of methyl vinyl ether to maleic anhydride is 2:1 to 1:2, more preferably (0.8 to 1.2):1, and the molecular weight ranges from 800,000 to 3,000,000, more preferably from 1,000,000 to 1,800,000.

[0029] The phosphate is a compound of one or more of tripolyphosphate, pyrophosphate, hexametaphosphate and sodium phytate; more preferably, it is a phosphate with a chain structure; and most preferably, it is a compound of one or more of sodium tripolyphosphate and sodium pyrophosphate.

[0030] An oral care product comprising 1-15% of the oral whitening composition, wherein the pH of the oral care product is 6-8, more preferably 6.5-7.5. The oral care product is a toothpaste, tooth powder, tooth strips, mouthwash, spray, mousse, gel, or aerosol.

[0031] Specific Examples and Comparative Examples

[0032] The mass percentages of the components in the oral products of Examples 1-7 and Comparative Examples 1-9 are shown in Tables 1 and 2, respectively.

[0033] Table 1: Example ratio

[0034]

[0035] Table 2: Comparative ratio

[0036]

[0037]

[0038] Performance Testing

[0039] (1) Cleaning Power Brushing Test: A dye solution was prepared and used to stain enamel blocks to simulate the stains caused by daily diet in adults. Using a controllable brushing instrument (L-8II), the dyed enamel blocks were brushed at a specific speed and load to simulate daily toothbrushing. The color difference ΔL between the enamel blocks before and after brushing was calculated to demonstrate the product's cleaning power. A larger ΔL value indicates stronger cleaning power and better whitening results. The dye solution was a mixture of coffee, soy sauce, ferric chloride, black tea, and gastric mucin.

[0040] Table 3-1: Cleaning power and whiteness improvement value after 2 minutes of brushing

[0041]

[0042] Table 3-2: Whiteness improvement value of cleaning power by brushing for 2 minutes

[0043]

[0044] Table 3-3: Statistical analysis of whiteness improvement after 2 minutes of cleaning power brushing (p-value statistics)

[0045]

[0046]

[0047] From the data in Tables 3-1 to 3-3, we can see that:

[0048] According to the results of the 2-minute brushing test, when Examples 1-9 were compared with Comparative Example 11 (without whitening functional raw materials), the ΔL values (whiteness improvement values) of the tooth blocks of Examples 1-9 were significantly higher than those of Comparative Example 11, and the p values were all less than 0.01, indicating extremely significant differences. This indicates that the formulations containing the oral whitening compositions of Examples 1-9 exhibited a whitening effect after 2 minutes of brushing, demonstrating a rapid whitening effect.

[0049] Comparing Comparative Examples 1-10 with Comparative Example 11 (raw materials without whitening efficacy), the ΔL values (whiteness improvement values) of the tooth blocks are similar, and the p values are all > 0.05, indicating that there is no statistically significant difference, indicating that Comparative Examples 1-10 do not exhibit whitening efficacy when brushed for 2 minutes.

[0050] Comparing Example 1-9 with Comparative Example 1-5, the ΔL value (whiteness improvement) of the tooth block of Example 1-9 was significantly higher, with p values of <0.05, indicating statistically significant differences. This indicates that Example 1-9 achieves a whitening effect in a shorter time and achieves rapid stain removal. This demonstrates that the whitening effect of the formulation of Example 1-9 is superior to that of a single PVM / MA or phosphate / sodium monofluorophosphate combination, and requires a shorter time.

[0051] Comparing Examples 1-9 with Comparative Examples 6-8, the results showed that the ΔL values (whiteness improvement) of the tooth blocks of Examples 1-9 were significantly higher, with p values of less than 0.05, indicating statistically significant differences. This indicates that Examples 1-9 achieve a whitening effect in a shorter time and achieve a rapid stain removal effect. This demonstrates that the combination of PVM / MA and phosphate / sodium monofluorophosphate requires a reasonable ratio to achieve a good synergistic effect.

[0052] Comparing Examples 1-9 with Comparative Examples 9 and 10, the results showed that the ΔL values (whiteness improvement) of the tooth blocks of Examples 1-9 were significantly higher, with p-values of less than 0.05, indicating statistically significant differences. This indicates that Examples 1-9 achieve whitening effects in a shorter time and achieve rapid stain removal. This demonstrates that excessively low or high molecular weights of PVM / MA can reduce the whitening efficacy of the PVM / MA and phosphate / sodium monofluorophosphate combination.

[0053] Table 4-1: Cleaning power and whiteness improvement after 8 minutes of brushing

[0054]

[0055] Table 4-2: Whiteness improvement value of cleaning power after 8 minutes of brushing

[0056]

[0057]

[0058] Table 4-3: Statistical analysis of whiteness improvement after 8 minutes of cleaning power brushing (p-value statistics)

[0059]

[0060] From the data in Tables 4-1 to 4-3, we can see that:

[0061] Based on the results of the 8-minute brushing test, Comparative Examples 1-10 were compared with Comparative Example 11 (without whitening ingredients). Comparative Examples 1, 2, and 3, which contained only PVM / MA, showed no significant difference, indicating that PVM / MA alone does not possess significant whitening efficacy. The ΔL values (whiteness improvement) of the blocks in Comparative Examples 4-10 were higher than those in Comparative Example 11, with p-values of <0.05, indicating statistically significant differences, indicating that whitening efficacy was also achieved after 8 minutes of brushing.

[0062] Comparing Example 1-9 with Comparative Examples 1 to 11 (without whitening efficacy raw materials), the ΔL value (whiteness improvement value) of the tooth block of Example 1-9 is significantly higher than that of Comparative Example 11, and the p value is <0.01, which is a very significant difference, indicating that Example 1-9 still shows a whitening effect after brushing for 8 minutes, and the whiteness difference between the two is large. The ΔL value of the tooth block of Example 1-9 is significantly higher than that of Comparative Examples 1 to 8, and the p value is <0.05, which is a significant difference, indicating that the whitening effect is better, further indicating that the whitening efficacy of a reasonable ratio of PVM / MA to phosphate / sodium monofluorophosphate is better. The ΔL value of the tooth block of Example 1-9 is significantly higher than that of Comparative Examples 9 to 10, and the p value is <0.05, which is a significant difference, indicating that a low or too high molecular weight of PVM / MA will reduce the whitening efficacy of the composition.

[0063] Examples 8 and 9 differ from Examples 5 and 7 only in the type of phosphate, but their ΔL values (whiteness improvement values) are slightly lower, indicating that the whitening effect of cyclic phosphates in the composition is slightly weaker than that of segmented sodium tripolyphosphate and sodium pyrophosphate. Therefore, the preferred phosphate is a combination of one or more of sodium tripolyphosphate and sodium pyrophosphate with chain molecular structures. (II) Long-term staining prevention test: Unstained bovine enamel blocks were subjected to a repeated cycle of "toothpaste treatment for 3 minutes - staining solution treatment for 15 hours". The color difference ΔL before and after the test was compared to determine whether 15-hour long-term staining prevention was possible. The smaller the ΔL value, the lighter the staining, the smaller the degree of reduction in the whiteness of the tooth block, and the better the staining prevention effect. The staining solution was a mixture of coffee, soy sauce, ferric chloride, black tea, and gastric mucin.

[0064] Table 5-1: Whiteness reduction values in the preventive dyeing test

[0065]

[0066] Table 5-2: Statistical analysis of whiteness reduction values in the prevention dyeing test (p-value statistics)

[0067]

[0068] From the data in Tables 5-1 and 5-2, we can see that:

[0069] According to the long-term staining prevention test results, when Examples 1-7 are compared with Comparative Example 11 (without whitening raw materials), the ΔL values (whiteness reduction values) of the tooth blocks of Examples 1-7 are significantly smaller than those of Comparative Example 11, and the p values are all <0.01, which are extremely significant differences, indicating that Examples 1-7 have a long-term staining prevention effect.

[0070] Comparing Comparative Examples 6-8 with Comparative Example 11 (raw materials without whitening efficacy), the ΔL value (whiteness reduction value) of the tooth blocks of Comparative Examples 6-8 is less than that of Comparative Example 11, and the p values are all <0.01, which are statistically significantly different, indicating that Comparative Examples 6-8 also have the efficacy of preventing staining.

[0071] Comparing Examples 1-7 with Comparative Examples 6-8, the tooth blocks of Examples 1-7 exhibited lower ΔL values (whiteness reduction), with p values all below 0.01, demonstrating statistically significant differences. This suggests that Examples 1-7 are more effective in preventing tooth staining. This demonstrates that the combination of PVM / MA and phosphate / sodium monofluorophosphate exhibits a synergistic effect, and that optimal results can only be achieved within a specific ratio.

[0072] (3) Teeth Whitening Clinical Trial: Orally healthy consumers were screened and a 4-week toothbrushing trial was conducted using both regular and combination whitening toothpastes. Changes in the subjects' tooth whiteness were recorded using a VITA 27-color tooth whiteness shade guide before the trial, after 2 weeks, and after 4 weeks. The smaller the tooth whiteness value, the whiter the teeth. The teeth whitening efficacy was compared by calculating the changes in tooth whiteness after 2 and 4 weeks.

[0073] Table 6: Teeth Whitening Clinical Trials

[0074]

[0075] From the data in Table 6, we can see that:

[0076] Comparing the teeth whitening clinical trial results of Example 3 and Comparative Example 4, Example 3 showed significant differences in tooth whiteness compared to the initial teeth whiteness values at both 2 and 4 weeks, indicating that a whitening effect was achieved after 2 weeks of use. Comparative Example 4 showed significant differences in tooth whiteness compared to the initial teeth whiteness values at 4 weeks, indicating that a whitening effect was achieved after 4 weeks of use. This indicates that the toothpaste of Example 5 can more quickly remove tooth stains and achieve a teeth whitening effect.

[0077] (IV) Crystal Growth Inhibition Rate: Dental calculus is primarily formed by the calcification of dental plaque on the tooth surface. The deposition of phosphorus and calcium on the tooth surface to form minerals such as hydroxyapatite was simulated in artificial saliva. The effectiveness of toothpaste in inhibiting calculus crystal growth was verified by adding a toothpaste containing a crystal growth inhibitor. The higher the crystal growth inhibition rate, the better the calculus prevention effect.

[0078] Table 7: Dental calculus prevention test - crystal growth inhibition rate

[0079]

[0080] From the data in Table 7, we can see that:

[0081] According to the results of the dental calculus prevention test, the crystal growth inhibition rates of toothpaste Examples 1-7 using the present composition were significantly higher than those of Comparative Examples 6-8 and Comparative Example 11, indicating that the combination of phosphate, sodium monofluorophosphate, and PVM / MA has a better effect in preventing dental calculus and requires scientific proportions for coordinated use.

[0082] Unless otherwise specified, the raw materials and equipment used in the present invention are commonly used in the art; the methods used in the present invention are conventional methods in the art unless otherwise specified.

[0083] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent transformation made to the above embodiment based on the technical essence of the present invention still fall within the scope of protection of the technical solution of the present invention.

Claims

1. A multi-effect synergistic oral whitening composition, characterized in that: Calculated based on the content in oral care products, it is composed of the following components in percentage by mass: Methyl vinyl ether / maleic anhydride copolymer 0.03-2%, Sodium monofluorophosphate 0.76-1.14%, 1-3% of phosphate with a chain structure; sodium tripolyphosphate and / or sodium pyrophosphate; The mass ratio of the methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate and phosphate is 1: (0.2-6): (0.2-30); The molar ratio of methyl vinyl ether to maleic anhydride in the methyl vinyl ether / maleic anhydride copolymer is 2:1 to 1:2, and the molecular weight is 1,000,000 to 3,000,000; The pH of the oral care product is 6-8.

2. The oral whitening composition according to claim 1, wherein: The mass ratio of the methyl vinyl ether / maleic anhydride copolymer, sodium monofluorophosphate and phosphate is 1:(0.4-2.5):(1-10).

3. The oral whitening composition according to claim 2, wherein: The molar ratio of methyl vinyl ether to maleic anhydride in the methyl vinyl ether / maleic anhydride copolymer is (0.8-1.2):1, and the molecular weight is 1,000,000-1,800,000.

4. The oral whitening composition according to any one of claims 1 to 3, characterized in that: The pH of the oral care product is 6.5-7.

5.

5. The oral whitening composition according to any one of claims 1 to 3, characterized in that: The oral care product is toothpaste, tooth powder, tooth strips, mouthwash, spray, mousse, gel or aerosol.

6. Use of the oral whitening composition according to any one of claims 1 to 3 in the preparation of oral care products.

7. The use according to claim 6, characterized in that: The oral care product is toothpaste, tooth powder, tooth strips, mouthwash, spray, mousse, gel or aerosol.

8. An oral care product, characterized in that: Contains the oral whitening composition according to any one of claims 1 to 3.

9. The oral care product according to claim 8, wherein: The pH of the oral care product is 6.5-7.

5.

10. The oral care product according to claim 8 or 9, characterized in that: It can be in the form of toothpaste, tooth powder, tooth strips, mouthwash, spray, mousse, gel or aerosol.

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