A conductive hydrogel mediated by amino-modified graphene quantum dots and its preparation method and application
By dispersing amino-modified graphene quantum dots in hydrogel and combining it with exogenous electrical stimulation to simulate the endogenous current of the wound, the problem of poor healing effect of graphene quantum dot repair gel was solved, and faster wound healing was achieved.
CN117126541BActive Publication Date: 2025-10-03JIANGSU UNIV
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Patent Information
- Application Number
- CN202311146628.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-09-06
- Publication Date
- 2025-10-03
- Estimated Expiration
- 2043-09-06
AI Technical Summary
Technical Problem
The existing repair gel prepared with graphene quantum dots has limited therapeutic effect on wound healing and is of low clinical value.
Method used
A conductive hydrogel mediated by amino graphene quantum dots is used. By dispersing amino graphene quantum dots in the hydrogel and combining it with exogenous electrical stimulation, the endogenous current at the wound is simulated, the migration and proliferation of dermal fibroblasts is promoted, and tissue growth is stimulated.
Benefits of technology
It accelerates the wound healing process and improves the healing efficiency of skin wounds in rats with dermal defects, and has good clinical application value.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention belongs to the technical field of tissue damage repair, and specifically relates to a conductive hydrogel mediated by aminated graphene quantum dots, and its preparation method and application. The conductive hydrogel mediated by aminated graphene quantum dots provided by the present invention comprises a hydrogel obtained by photocuring acrylamide monomers, and aminated graphene quantum dots dispersed in the hydrogel; the mass of the aminated graphene quantum dots accounts for ≤0.3% of the mass of the acrylamide monomers. When the conductive hydrogel provided by the present invention is combined with exogenous electrical stimulation, an external current is applied to the wound to simulate the endogenous current at the wound, guiding dermal fibroblasts (DFs) to migrate and proliferate toward the wound along the electrical gradient, stimulating tissue growth, and thus accelerating wound healing.
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