A Chinese medicine composition for treating erectile dysfunction and its preparation method and application

Abstract

The invention discloses a Chinese medicine composition for treating erectile dysfunction and a preparation method and application thereof, and belongs to the field of medical technology. The raw materials of the Chinese medicine composition for treating erectile dysfunction include by mass: 5-50 parts of Gastrodia elata, 5-50 parts of Uncaria rhynchophylla, 10-120 parts of calcined Cassiae, 10-120 parts of calcined Mother of Pearl, 10-120 parts of raw oyster, 5-50 parts of Schisandra chinensis, 5-50 parts of Lycium barbarum, 5-50 parts of Rubus idaeus, 5-50 parts of Ligustrum lucidum, 5-50 parts of Eucommia ulmoides, 5-50 parts of Cyathula officinalis, 5-60 parts of Salvia miltiorrhiza, 10-120 parts of Epimedium, 5-50 parts of Morinda officinalis, 10-120 parts of Tribulus terrestris and 10-120 parts of dried peach. The invention designs a Chinese medicine composition for treating erectile dysfunction of liver yang hyperactivity type, which has the characteristics of good efficacy, low recurrence rate and no side effects.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a Chinese medicine composition for treating erectile dysfunction, and a preparation method and application thereof. Background Art

[0002] Erectile dysfunction (ED) is also known as impotence in clinical practice. It is a common type of male sexual dysfunction. The causes of the disease include advanced age, cardiovascular diseases such as peripheral vascular disease or myocardial infarction, dyslipidemia, prostate disease, etc. The clinical symptoms of patients with erectile dysfunction are that the penis cannot erect, or it can erect but cannot meet the requirements of completing normal sexual life. There are many clinical syndromes of ED, which are often divided into liver qi stagnation, liver and kidney deficiency, life gate fire decline, liver meridian dampness and heat, and qi stagnation and blood stasis. Traditional Chinese medicine describes it as impotence and inability to erect, erection but not firm, and firmness but not for long, which is called impotence. If the disease is not treated promptly and effectively, long-term persistence can cause more serious reproductive system diseases, while affecting the patient's mental health, affecting the relationship between husband and wife, and even leading to family breakdown. Therefore, early detection and early treatment of the disease are very important.

[0003] In recent years, erectile dysfunction has been mostly treated clinically with Western medicine, such as sildenafil citrate, a selective inhibitor of phosphodiesterase type 5 (PDE5) specific to cyclic guanosine monophosphate (cGMP). This type of drug can significantly improve the congestion of the patient's corpus cavernosum, allowing the patient to achieve normal erectile function. However, the drug has certain side effects, is relatively expensive, and needs to be taken for a long time, or taken before each sexual intercourse, which cannot achieve the purpose of curing the root cause. Therefore, finding a therapeutic drug or treatment plan for erectile dysfunction with good efficacy, low recurrence rate and few side effects is a key issue that needs to be solved. Summary of the invention

[0004] The object of the present invention is to provide a Chinese medicine composition for treating erectile dysfunction, and a preparation method and application thereof. The invention designs a Chinese medicine composition for treating erectile dysfunction of liver yang hyperactivity type, which has the characteristics of good efficacy, low recurrence rate and no side effects. The preparation method of the present invention is simple, fast, efficient, easy to operate, and the prepared compound preparation is easy to carry and convenient to take, and has good application value.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] One of the technical solutions of the present invention is to provide a Chinese medicine composition for treating erectile dysfunction, wherein the raw materials, calculated by weight, include:

[0007] 5-50 parts of Gastrodia elata, 5-50 parts of Uncaria rhynchophylla, 10-120 parts of calcined Cassia seed, 10-120 parts of calcined Mother of Pearl, 10-120 parts of raw oyster, 5-50 parts of Schisandra chinensis, 5-50 parts of Lycium barbarum, 5-50 parts of Rubus idaeus, 5-50 parts of Ligustrum lucidum, 5-50 parts of Eucommia ulmoides, 5-50 parts of Cyathula officinalis, 5-60 parts of Salvia miltiorrhiza, 10-120 parts of Epimedium, 5-50 parts of Morinda officinalis, 10-120 parts of Tribulus terrestris and 10-120 parts of dried peach.

[0008] Preferably, the raw materials, measured by mass, include:

[0009] 15-40 parts of Gastrodia elata, 15-40 parts of Uncaria rhynchophylla, 30-90 parts of calcined Cassiae, 30-90 parts of calcined Mother of Pearl, 30-90 parts of raw oyster, 10-40 parts of Schisandra chinensis, 15-40 parts of Lycium barbarum, 15-50 parts of Rubus idaeus, 15-40 parts of Ligustrum lucidum, 5-50 parts of Eucommia ulmoides, 10-40 parts of Cyathula officinalis, 20-50 parts of Salvia miltiorrhiza, 30-90 parts of Epimedium, 5-50 parts of Morinda officinalis, 30-90 parts of Tribulus terrestris and 30-90 parts of dried peach.

[0010] More preferably, the raw materials are, by mass,

[0011] 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oyster, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Ligustrum lucidum, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris and 40 parts of dried peach.

[0012] In the Chinese medicine composition proposed by the present invention, Gastrodia elata suppresses liver yang, dispels wind and dredges collaterals, Uncaria rhynchophylla calms wind and calms dizziness, clears heat and soothes the liver, and they are all monarch drugs. Semen Cassiae calms the liver and suppresses yang, clears the liver and improves eyesight, Mother of Pearl calms the liver and suppresses yang, calms the mind and calms the convulsion, Raw Oyster calms the mind, astringes and consolidates, and the three are used together to help the monarch drug calm the liver and suppress yang; Schisandra chinensis astringes and consolidates, nourishes the kidney and calms the heart, Lycium barbarum nourishes the liver and kidney, improves sperm and improves eyesight, Rubus idaeus nourishes the liver and kidney, consolidates sperm and reduces urine, Ligustrum lucidum nourishes the liver and kidney, and Eucommia ulmoides nourishes the liver and kidney, strengthens tendons and bones, and the five are used together to help the monarch drug nourish yin and suppress yang to treat the root of kidney deficiency, and they are all minister drugs. Danshen activates blood circulation, removes blood stasis, cools blood and relieves pain, while Sichuan Cyathula activates blood circulation and promotes diuresis, guiding blood downward; Epimedium and Morinda officinalis both nourish the kidney and strengthen yang, dispel wind and dampness; Tribulus terrestris calms the liver and relieves depression, activates blood circulation and dispels wind; Prunus persica can astringe sweat, restrain essence and stop bleeding; all the herbs are used together as adjuvants to remove blood stasis caused by long-term illness and liver qi stagnation, and to consolidate essence and qi. The whole prescription takes into account both the symptoms and the root cause, and has the effects of nourishing yin and suppressing yang, tonifying the liver and kidney, activating blood circulation and removing blood stasis, and boosting yang.

[0013] The second technical solution of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0014] The raw materials are mixed, and an extractant is added for extraction to obtain an extract solution, thereby preparing the traditional Chinese medicine composition.

[0015] Preferably, the extractant is at least one of water, ethanol, ether, chloroform and glycerol.

[0016] Preferably, the extraction method comprises decoction, reflux or continuous reflux extraction.

[0017] More preferably, the extraction comprises the following steps: adding 8-12 times the total mass of the raw material to soak the raw material for 30-60 minutes, boiling for 1-2 hours to obtain a primary filtrate and a filter residue; then adding 6-10 times the total mass of the raw material to the filter residue and boiling for 1-1.5 hours, filtering to obtain a secondary filtrate; combining the primary filtrate and the secondary filtrate into a total filtrate, and then concentrating the total filtrate to a volume mass ratio of 1 mL: 2 g with the raw material, thereby completing the extraction.

[0018] More preferably, after obtaining the extract, a concentration step is further included; the concentration includes the following steps: adding 50-60% by volume of ethanol to the extract, standing for 24-48 hours, taking the supernatant to recover the ethanol until there is no alcohol taste, and concentrating to a thick paste with a relative density of 1.2-1.5, thereby completing the concentration.

[0019] As a preferred embodiment, in the method for preparing the above-mentioned drug, 90% ethanol is added in step (2) to make the alcohol content of the drug solution reach 50% to 60%, and the drug solution is allowed to stand for 24 to 48 hours, and the supernatant is taken to recover the ethanol until there is no alcohol taste, and concentrated to a relative density of 1.2 to 1.5.

[0020] The third technical solution of the present invention is to provide a compound preparation, which contains the above-mentioned traditional Chinese medicine composition.

[0021] Pharmaceutically acceptable excipients may be added to the compound preparation, and then prepared into common oral dosage forms such as oral liquid, granules, tablets, capsules, pills, etc. by conventional Chinese medicine preparation methods.

[0022] More preferably, the auxiliary material is at least one of honey, sucrose, dextrin, glycerol, steviol glycoside and xylitol.

[0023] The fourth technical solution of the present invention is to provide an application of the above-mentioned Chinese medicine composition or compound preparation in the preparation of a drug for treating erectile dysfunction caused by hyperactivity of liver yang.

[0024] The beneficial technical effects of the present invention are as follows:

[0025] The Chinese medicine composition designed by the present invention has been clinically verified to have good effects of calming the liver and suppressing yang, nourishing the liver and kidney, and promoting blood circulation and removing blood stasis; it is mainly used to treat patients who cannot have an erection, have a weak erection or have a strong erection but not for long, accompanied by dizziness, tinnitus, soreness of the waist and knees, fatigue, or fear of heat and easy sweating, dark tongue, thin white tongue coating, and stringy and rapid pulse.

[0026] The inventors found through clinical observation that, among the TCM syndrome types of patients with erectile dysfunction, the liver yang hyperactivity type is more common, so the present invention designs a Chinese medicine composition for treating liver yang hyperactivity type erectile dysfunction, which has the characteristics of good efficacy, low recurrence rate and no side effects. The preparation method of the present invention is simple, fast, efficient, easy to operate, and the prepared compound preparation is easy to carry and convenient to take, and has good application value. DETAILED DESCRIPTION

[0027] Now, various exemplary embodiments of the present invention are described in detail, and this detailed description should not be considered as a limitation of the present invention, but should be understood as a more detailed description of certain aspects, characteristics and embodiments of the present invention. It should be understood that the terms described in the present invention are only for describing specific embodiments and are not used to limit the present invention.

[0028] In addition, for the numerical range in the present invention, it is understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. The intermediate value in any stated value or stated range, and each smaller range between any other stated value or intermediate value in the range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0029] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which the invention pertains. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention.

[0030] The words “include,” “including,” “have,” “contain,” etc. used in the present invention are open-ended terms, meaning including but not limited to.

[0031] The concentration of ethanol used in the following examples of the present invention is 90%.

[0032] All raw materials used in the following embodiments of the present invention are commercially available products.

[0033] Example 1

[0034] An oral liquid, composed of the following raw materials in parts by weight:

[0035] 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oyster, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Ligustrum lucidum, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris, 1 part of steviol glycosides and 40 parts of dried peach.

[0036] The preparation method of oral solution is as follows:

[0037] (1) Prepare the above raw materials, add water 10 times the total mass of the raw materials to soak the raw materials for 30 minutes, and then boil for 2 hours to obtain a primary filtrate and a filter residue; then add water 6 times the total mass of the raw materials to the filter residue and boil for 1.5 hours, and filter to obtain a secondary filtrate; combine the primary filtrate and the secondary filtrate to obtain a total filtrate, and then concentrate the total filtrate to a volume mass ratio of 1 mL to 2 g with the raw materials to obtain an extract.

[0038] (2) Add ethanol to the extract so that the volume percentage of ethanol in the mixed system is 60%, let it stand for 24 hours, take the supernatant, recover the ethanol until there is no alcohol taste, concentrate it to a thick paste with a relative density of 1.2, add distilled water to 1000 mL, add stevioside, mix well, let it stand for 18 hours, filter, sterilize, and can to prepare an oral solution.

[0039] Example 2

[0040] A capsule, composed of the following raw materials in parts by weight:

[0041] 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oyster, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Ligustrum lucidum, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris, 40 parts of dried peach and 60 parts of dextrin.

[0042] The preparation method of the capsule is as follows:

[0043] (1) Prepare all raw materials except dextrin, add water 10 times the total mass of the raw materials to soak the raw materials for 30 minutes, and then boil for 2 hours to obtain a primary filtrate and a filter residue; then add water 6 times the total mass of the raw materials to the filter residue and boil for 1.5 hours, and filter to obtain a secondary filtrate; combine the primary filtrate and the secondary filtrate to obtain a total filtrate, and then concentrate the total filtrate to a volume mass ratio of 1 mL: 2 g with the raw materials to obtain an extract.

[0044] (2) Add ethanol to the extract so that the volume percentage of ethanol in the mixed system is 55%, let it stand for 48 hours, take the supernatant, recover the ethanol until there is no alcohol taste, and concentrate it to a thick paste with a relative density of 1.3. Then add dextrin, mix well, vacuum dry, crush, granulate, dry, granulate, and encapsulate to prepare capsules.

[0045] Example 3

[0046] A tablet, composed of the following raw materials in parts by weight:

[0047] 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oyster, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Ligustrum lucidum, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris, 40 parts of dried peach and 50 parts of dextrin.

[0048] The preparation method of tablets is as follows:

[0049] (1) Prepare all raw materials except dextrin, add water 10 times the total mass of the raw materials to soak the raw materials for 30 minutes, and then boil for 2 hours to obtain a primary filtrate and a filter residue; then add water 6 times the total mass of the raw materials to the filter residue and boil for 1.5 hours, and filter to obtain a secondary filtrate; combine the primary filtrate and the secondary filtrate to obtain a total filtrate, and then concentrate the total filtrate to a volume mass ratio of 1 mL: 2 g with the raw materials to obtain an extract.

[0050] (2) Add ethanol to the extract so that the volume percentage of ethanol in the mixed system is 60%, let it stand for 48 hours, take the supernatant, recover the ethanol until there is no alcohol taste, concentrate it to a thick paste with a relative density of 1.3, add dextrin, mix well, vacuum dry, crush, granulate, dry, granulate, press, and coat to make tablets.

[0051] Example 4

[0052] A granule, composed of the following raw materials in parts by weight:

[0053] 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oyster, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Ligustrum lucidum, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris and 40 parts of dried peach.

[0054] The preparation method of granules is as follows:

[0055] (1) Prepare the above raw materials, add water 10 times the total mass of the raw materials to soak the raw materials for 30 minutes, and then boil for 2 hours to obtain a primary filtrate and a filter residue; then add water 6 times the total mass of the raw materials to the filter residue and boil for 1.5 hours, and filter to obtain a secondary filtrate; combine the primary filtrate and the secondary filtrate to obtain a total filtrate, and then concentrate the total filtrate to a volume mass ratio of 1 mL to 2 g with the raw materials to obtain an extract.

[0056] (2) Add ethanol to the extract so that the volume percentage of ethanol in the mixed system is 50%, let it stand for 48 hours, take the supernatant, recover the ethanol until there is no alcohol taste, and concentrate it to a thick paste with a relative density of 1.2. Granulate it in one step, shape it into whole particles, and package it into granules.

[0057] Example 5 (The only difference from Example 1 is that the thick paste is processed differently)

[0058] A soft capsule, composed of the following raw materials in parts by weight:

[0059] 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oysters, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Fructus Ligustri Lucidi, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris, 40 parts of dried peach and 15 parts of glycerol.

[0060] The preparation method of soft capsule is as follows:

[0061] (1) Prepare the above raw materials, add water 10 times the total mass of the raw materials to soak the raw materials for 30 minutes, and then boil for 2 hours to obtain a primary filtrate and a filter residue; then add water 6 times the total mass of the raw materials to the filter residue and boil for 1.5 hours, and filter to obtain a secondary filtrate; combine the primary filtrate and the secondary filtrate to obtain a total filtrate, and then concentrate the total filtrate to a volume mass ratio of 1 mL to 2 g with the raw materials to obtain an extract.

[0062] (2) Add ethanol to the extract so that the volume percentage of ethanol in the mixed system is 60%, let it stand for 24 hours, take the supernatant, recover the ethanol until there is no alcohol taste, concentrate it to a thick paste with a relative density of 1.2, add glycerol, mix well, dry, drip it into soft capsules, and package it to make soft capsules.

[0063] Effect verification

[0064] (1) Clinical trials of Chinese medicine compositions

[0065] 1. Inclusion criteria for subjects with erectile dysfunction of liver yang hyperactivity type: (1) Age: 18-45 years old; (2) Having a fixed sexual partner and regular sex life; (3) Meeting the diagnostic criteria for ED, with an International Index of Erectile Function (IIEF-5) score of <22 points; (4) Meeting the phlegm-dampness constitution classification in the "Classification and Determination Table of Chinese Medicine Constitution" formulated by the China Association of Traditional Chinese Medicine; (5) Not having used similar medications in the month before treatment; (6) Not taking any medications that affect sexual function during treatment; (7) The patients were informed and agreed to participate in this study.

[0066] Exclusion criteria: (1) congenital genital malformation and dysplasia; (2) severe genital system infection; (3) ED after genitourinary surgery and lower abdominal surgery; (4) severe heart, liver, and kidney dysfunction; (5) severe hypertension, diabetes, and blood diseases that are not controlled; (6) severe mental illness.

[0067] 2. Final selected testers: 90 patients diagnosed with erectile dysfunction (impotence) of liver yang hyperactivity type in Jiangsu Provincial Hospital of Traditional Chinese Medicine from January 2022 to December 2022 were selected. The patients were aged 18 to 45 years old, with an average of 28.5 years old. None of them had serious diseases such as heart, brain, liver, kidney and hematopoietic system.

[0068] 3. Treatment plan: The test subject takes 400 mL of the Chinese medicine composition prepared in Example 1 every day, divided into two doses of 200 mL each after meals, and the treatment cycle is 4 weeks.

[0069] 4. Observation index: observe the erectile function index score (average value) and adverse reactions of the test subjects before and after treatment. The erectile function index scoring standard is based on the International Erectile Dysfunction Index (IIEF-5).

[0070] 5. Results:

[0071] The erectile function index scores before and after treatment are shown in Table 1.

[0072] Table 1 Functional index scores

[0073]

[0074] (Note: p values ​​are all less than 0.01)

[0075] As shown in Table 1, after 4 weeks of treatment, the erectile function index scores of the test subjects were significantly improved compared with those before treatment.

[0076] Safety observation: No abnormalities were found in the patients' liver, kidney function, blood and urine routine tests before and after treatment.

[0077] Therefore, it can be concluded that the Chinese medicine composition of the present invention can be used to treat liver-yang hyperactivity type erectile dysfunction, has the characteristics of good efficacy and no side effects, and its preparation method is simple, fast, efficient, easy to operate, easy to carry and convenient to take.

[0078] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A Chinese medicine composition for treating liver yang hyperactivity type erectile dysfunction, characterized in that: The raw materials are calculated by weight as follows: 5-50 parts of Gastrodia elata, 5-50 parts of Uncaria rhynchophylla, 10-120 parts of calcined Cassia seed, 10-120 parts of calcined Mother of Pearl, 10-120 parts of raw oyster, 5-50 parts of Schisandra chinensis, 5-50 parts of Lycium barbarum, 5-50 parts of Rubus idaeus, 5-50 parts of Ligustrum lucidum, 5-50 parts of Eucommia ulmoides, 5-50 parts of Cyathula officinalis, 5-60 parts of Salvia miltiorrhiza, 10-120 parts of Epimedium, 5-50 parts of Morinda officinalis, 10-120 parts of Tribulus terrestris and 10-120 parts of dried peach.

2. The Chinese medicine composition according to claim 1, characterized in that: The raw materials are calculated by weight: 15-40 parts of Gastrodia elata, 15-40 parts of Uncaria rhynchophylla, 30-90 parts of calcined Cassiae, 30-90 parts of calcined Mother of Pearl, 30-90 parts of raw oyster, 10-40 parts of Schisandra chinensis, 15-40 parts of Lycium barbarum, 15-50 parts of Rubus idaeus, 15-40 parts of Ligustrum lucidum, 5-50 parts of Eucommia ulmoides, 10-40 parts of Cyathula officinalis, 20-50 parts of Salvia miltiorrhiza, 30-90 parts of Epimedium, 5-50 parts of Morinda officinalis, 30-90 parts of Tribulus terrestris and 30-90 parts of dried peach.

3. The Chinese medicine composition according to claim 1, characterized in that The raw materials are calculated by mass: 15 parts of Gastrodia elata, 15 parts of Uncaria rhynchophylla, 30 parts of calcined Cassiae, 30 parts of calcined Mother of Pearl, 30 parts of raw oyster, 12 parts of Schisandra chinensis, 15 parts of Lycium barbarum, 15 parts of Rubus idaeus, 15 parts of Ligustrum lucidum, 10 parts of Eucommia ulmoides, 12 parts of Cyathula officinalis, 20 parts of Salvia miltiorrhiza, 30 parts of Epimedium, 15 parts of Morinda officinalis, 30 parts of Tribulus terrestris and 40 parts of dried peach.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: The raw materials are mixed, and an extractant is added for extraction to obtain an extract solution, thereby preparing the traditional Chinese medicine composition.

5. The method for preparing the Chinese medicine composition according to claim 4, characterized in that: The extraction comprises the following steps: adding water 8 to 12 times the total mass of the raw material to soak the raw material for 30 to 60 minutes, and then boiling for 1 to 2 hours to obtain a primary filtrate and a filter residue; then adding water 6 to 10 times the total mass of the raw material to the filter residue and boiling for 1 to 1.5 hours, and filtering to obtain a secondary filtrate; combining the primary filtrate and the secondary filtrate to form a total filtrate, and then concentrating the total filtrate to a volume mass ratio of 1 mL to 2 g with the raw material, thereby completing the extraction.

6. The preparation method according to claim 4, characterized in that: After obtaining the extract, a concentration step is further included; the concentration includes the following steps: Add 50-60% by volume of ethanol to the extract, let it stand for 24-48 hours, take the supernatant, remove the ethanol and concentrate it to a thick paste with a relative density of 1.2-1.5, thus completing the concentration.

7. A compound preparation, characterized in that: The compound preparation is prepared from the Chinese medicine composition according to any one of claims 1 to 3.

8. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the compound preparation according to claim 7 in the preparation of a drug for treating erectile dysfunction due to hyperactivity of liver yang.

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