A temperature control device applied to a protein analyzer

Abstract

A temperature control device applied to a protein analyzer, comprising a reaction disk base, a reaction disk body and reaction cups. The reaction disk base is provided with an annular reaction disk groove. The reaction disk body is rotatably connected to the reaction disk base. The reaction disk body is provided with a plurality of heat conduction frames distributed circumferentially, and the heat conduction frames all extend into the reaction disk groove. The heat conduction frames are provided with heating holes with openings facing upward, and the reaction cups are inserted into the heating holes. The outer wall of the heat conduction frame is provided with light windows penetrating transversely to the heating holes. The reaction disk groove is filled with a liquid medium, the liquid medium is in contact with the heat conduction frame and the liquid level of the liquid medium is lower than the light windows. The above solution realizes efficient and stable temperature control of the reaction cups through continuous heat conduction of the liquid medium in the reaction disk groove to the heat conduction frames in a moving state; at the same time, by opening light windows on the heat conduction frames that penetrate to the heating holes and the liquid level of the liquid medium is lower than the light windows, it is realized that an external sensor can pass through the light windows to accurately detect the reaction cups.

Description

Technical Field

[0001] The present invention relates to the technical field of temperature control devices, and particularly to a temperature control device applied to a protein analyzer. Background Art

[0002] IVD instruments are instruments for in vitro detection of human body fluids. Their detection process needs to be carried out in a specific environment. Among them, the most important is that the temperature of the reaction process needs to be consistent with the human body temperature; secondly, the reagents also need to be stored at a suitable temperature to ensure the stability of the reagents. Therefore, the temperature control module of the instrument is one of the important components of the IVD instrument.

[0003] Currently, there are mainly four methods for the temperature control systems on the market: air bath, water bath, constant temperature liquid bath, and solid bath. For example, Beckman 800 adopts the air bath method. The air bath indirectly heats the temperature of the liquid in the reaction cup by heating the air. This method generally uses a patch heater to heat the air and combines a fan for air circulation. The structure is convenient and simple, but it is easily affected by the ambient temperature and has poor accuracy; Mindray's BS-280 adopts the water bath method. This method generally uses an isolated heater to heat deionized water and uses a magnetic pump for circulation. Its temperature control is stable, with high accuracy, and is not easily affected by the external environment. However, the water bath may cause bacterial growth, and after the temperature rises, the water will condense into fog, causing the wall of the reaction cup to become blurred, resulting in errors in optical signals. This problem is difficult to solve and will lead to inaccurate detection results; the operation mode of the constant temperature liquid bath is basically the same as that of the water bath method. This method has a good constant temperature effect, but on the one hand, the technical requirements are high and the cost of the constant temperature liquid is high. On the other hand, the constant temperature liquid will cause refraction and scattering of light, which will have a greater impact on the detection results and can only be used in transmission biochemical analyzers, while specific protein analyzers using the scattering optical method are not applicable; the solid bath indirectly heats the liquid in the reaction cup by heating the solid. This method has a fast heating speed, but because the heating block is attached to the reaction cup, it is difficult to achieve in a moving scenario and the heating effect is unstable. Summary of the Invention

[0004] The object of the present invention is to provide a temperature control device applied to a protein analyzer, which can achieve efficient and stable temperature control of the reaction cup in a moving scenario and can also accurately detect the reaction cup.

[0005] To solve the above problems, the present invention provides a temperature control device applied to a protein analyzer, including a reaction disk base, a reaction disk body, and reaction cups. The reaction disk base is provided with an annular reaction disk groove with an upward-opening notch. The reaction disk body is rotatably connected to the reaction disk base with the vertical direction as the axis. The reaction disk body is provided with a plurality of heat-conducting frames distributed circumferentially, and the heat-conducting frames all extend into the reaction disk groove. The heat-conducting frames are provided with heating holes with upward openings, and the reaction cups are inserted into the heating holes. The outer wall of the heat-conducting frame is provided with a light window that penetrates horizontally to the heating hole. The reaction disk groove is filled with a liquid medium, and the liquid medium is in contact with the heat-conducting frame and the liquid level of the liquid medium is lower than the light window.

[0006] In the above solution, the heat-conducting frame moves circumferentially in the reaction disk groove driven by the reaction disk body. Since the reaction disk groove of the reaction disk base is filled with a liquid medium at a preset temperature, the liquid medium can continuously conduct heat to the heat-conducting frame in the moving state, ensuring that the temperature value of the heat-conducting frame is relatively stable. Then, the heat-conducting frame transfers the heat to the reaction cup in the heating hole, ultimately realizing efficient and stable temperature control of the reaction cup. At the same time, in the above solution, a light window that penetrates to the heating hole is opened on the heat-conducting frame, and the light window allows light to penetrate, so that an external sensor can detect the reaction cup in the heating hole through the light window. At the same time, since the liquid level of the liquid medium is lower than the light window, it will not affect the light at the position of the light window, ensuring the accuracy of the detection result.

[0007] Preferably, the reaction disk body is further provided with a limit seat corresponding to each heat-conducting frame one by one. The limit seat is located above the corresponding heat-conducting frame, and the limit seat is provided with a vertical limit hole. The limit hole is arranged opposite to the corresponding heating hole. The limit hole is used to limit the upper part of the reaction cup so that there is a gap between the outer peripheral wall of the lower part of the reaction cup and the inner peripheral wall of the heating hole. The limit hole on the limit seat realizes the supporting and limiting effect on the reaction cup on the one hand, ensuring the fixation of the reaction cup relative to the heat-conducting frame and avoiding the problem that the shaking of the reaction cup affects the detection result. On the other hand, there is a gap between the outer peripheral wall of the lower part of the reaction cup and the inner peripheral wall of the heating hole. Then, the heat of the heat-conducting frame is first transferred to the air in the gap between the outer peripheral wall of the reaction cup and the inner peripheral wall of the heating hole, and then transferred to the reaction cup, forming a temperature control method similar to an air bath, ensuring that the heat received by the reaction cup is more uniform and stable.

[0008] Preferably, the top end of the reaction cup is provided with a supporting part. The supporting part is placed above the corresponding limit hole and there is a gap between the bottom side wall of the reaction cup and the bottom of the heating hole, so that the heat of the heat-conducting frame is first transferred to the air in the gap between the bottom side wall of the reaction cup and the bottom of the heating hole, and then transferred to the reaction cup, further improving the uniformity of the heat received by the reaction cup.

[0009] Preferably, there is a gap between the outer side wall of the heat conduction frame and the groove wall of the reaction disc groove, and there is a gap between the bottom side wall of the heat conduction frame and the bottom of the reaction disc groove, so that the liquid medium can enter the above gaps to stably heat the heat conduction frame.

[0010] Preferably, the reaction disc body is provided with a slot arranged horizontally corresponding to the heat conduction frame, and the outer side wall of the heat conduction frame is provided with a fixing block clamped to the slot, so as to realize the fixed connection of the heat conduction frame relative to the reaction disc body.

[0011] Preferably, there is a heat insulation lining between the slot and the fixing block, and the heat insulation lining can play a heat insulation role to avoid the heat dissipation problem caused by the heat of the heat conduction frame being transmitted to the reaction disc body through the fixing block.

[0012] Preferably, the bottom of the heat conduction frame is provided with a convex platform extending outwards, so as to increase the contact volume between the heat conduction frame and the liquid medium and improve the heating efficiency of the liquid medium on the heat conduction frame.

[0013] Preferably, the liquid medium is water or oil, so that it has a large specific heat capacity, low cost, and can effectively heat the heat conduction frame.

[0014] Preferably, the reaction cup is made of quartz material, so that it has excellent heat conduction performance, effectively improves the heating rate of the reaction cup, and can make the temperature of the reaction cup more stable.

[0015] Preferably, the groove wall of the reaction disc groove is provided with an installation part for connecting the sensor, and the installation part is arranged towards the light window. Description of the Drawings

[0016] Figure 1 It is an overall schematic diagram of a temperature control device applied to a protein analyzer;

[0017] Figure 2 It is a side view schematic diagram of a temperature control device applied to a protein analyzer;

[0018] Figure 3 It is a sectional view schematic diagram along the Figure 2 A-A section line in

[0019] Figure 4 It is Figure 3 a partial enlarged schematic diagram of area B in

[0020] Figure 5 It is a schematic diagram of the reaction disc groove of a temperature control device applied to a protein analyzer filled with a liquid medium.

[0021] Description of the reference numerals,

[0022] 1. Reaction disc base; 11. Reaction disc groove; 12. Installation part; 2. Reaction disc body; 21. Slot; 22. Heat insulation lining; 3. Reaction cup; 31. Support part; 4. Heat conduction frame; 41. Heating hole; 42. Light window; 43. Fixed block; 44. Boss; 5. Limit seat; 51. Limit hole; 6. Liquid medium. Specific embodiments

[0023] To make the above objects, features and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention. Additionally, it should be noted that all directional indicators (such as up, down, left, right, front, back, inside, outside) in the embodiments of the present invention are only used to explain the relative position relationship and movement conditions between components in a specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indicators will also change accordingly.

[0024] Please refer to Figures 1 - 5 , a temperature control device applied to a protein analyzer provided by an embodiment of the present invention includes a reaction disc base 1, a reaction disc body 2 and a reaction cup 3. The reaction disc base 1 is provided with a ring-shaped reaction disc groove 11 with an upwardly opened notch. The reaction disc body 2 is rotatably connected to the reaction disc base 1 with the vertical axis. The reaction disc body 2 is provided with a plurality of heat conduction frames 4 distributed circumferentially, and the heat conduction frames 4 all extend into the reaction disc groove 11. The heat conduction frames 4 are provided with heating holes 41 with upward openings. The reaction cup 3 is inserted into the heating holes 41. The outer wall of the heat conduction frame 4 is provided with light windows 42 that penetrate transversely to the heating holes 41. The reaction disc groove 11 is filled with a liquid medium 6. The liquid medium 6 is in contact with the heat conduction frame 4 and the liquid level of the liquid medium 6 is lower than the light windows 42.

[0025] In the above solution, both the reaction disk body 2 and the reaction disk base 1 are of disk-shaped structures. The heat conduction frame 4 moves circumferentially in the reaction disk groove 11 under the drive of the reaction disk body 2. Since the reaction disk groove 11 of the reaction disk base 1 is filled with a liquid medium 6 at a preset temperature, the liquid medium 6 can continuously conduct heat to the heat conduction frame 4 in a moving state, ensuring that the temperature value of the heat conduction frame 4 is relatively stable. Then, the heat conduction frame 4 transfers the heat to the reaction cup 3 in the heating hole 41, ultimately achieving efficient and stable temperature control of the reaction cup 3. At the same time, in the above solution, a light window 42 penetrating through to the heating hole 41 is opened on the heat conduction frame 4, and the light window 42 allows light to penetrate, enabling an external sensor to detect the reaction cup 3 in the heating hole 41 through the light window 42. Since the liquid level of the liquid medium 6 is lower than the light window 42, it will not affect the light at the position of the light window 42, ensuring the accuracy of the detection result. In addition, the liquid medium 6 can be made of water or oil, thus having a large specific heat capacity and a low cost, and being able to effectively heat the heat conduction frame 4.

[0026] Since what needs to be simulated is the human body environment, in this embodiment, the temperature of the liquid medium 6 is maintained at 37 °C, so that the heat conduction frame 4 in contact with the liquid medium 6 is also heated to 37 °C. The heat conduction frame 4 is preferably made of copper material, thus having good heat conduction performance.

[0027] In this embodiment, the reaction disk body 2 is further provided with a limit seat 5 corresponding to each heat conduction frame 4 one by one. The limit seat 5 is located above the corresponding heat conduction frame 4, and the limit seat 5 is provided with a vertical limit hole 51, and the limit hole 51 is arranged opposite to the corresponding heating hole 41. The aperture of the limit hole 51 is equal to the outer diameter of the upper part of the reaction cup 3, and the aperture of the heating hole 41 is larger than the outer diameter of the lower part of the reaction cup 3, so that the limit hole 51 can limit and support the upper part of the reaction cup 3, leaving a gap between the outer peripheral wall of the lower part of the reaction cup 3 and the inner peripheral wall of the heating hole 41.

[0028] The limit hole 51 on the limit seat 5 realizes the function of supporting and limiting the reaction cup 3 on the one hand, ensuring the fixation of the reaction cup 3 relative to the heat conduction frame 4 and avoiding the problem that the shaking of the reaction cup 3 affects the detection result. On the other hand, it leaves a gap between the outer peripheral wall of the lower part of the reaction cup 3 and the inner peripheral wall of the heating hole 41. Then, the heat of the heat conduction frame 4 is first transferred to the air in the gap between the outer peripheral wall of the reaction cup 3 and the inner peripheral wall of the heating hole 41, and then transferred to the reaction cup 3, forming a temperature control method similar to an air bath, ensuring that the heat received by the reaction cup 3 is more uniform and stable.

[0029] Further, the heating hole 41 is a blind hole, and a support portion 31 is provided at the top end of the reaction cup 3. In this embodiment, the support portion 31 is a flanging extending outward. The support portion 31 is placed above the corresponding limiting hole 51, and the height of the reaction cup 3 is less than the height of the heating hole 41, so that a gap is left between the bottom side wall of the reaction cup 3 and the bottom of the heating hole 41. Thus, the heat of the heat conducting frame 4 is first transferred to the air in the gap between the bottom side wall of the reaction cup 3 and the bottom of the heating hole 41, and then transferred to the reaction cup 3, further improving the uniformity of the heat received by the reaction cup 3.

[0030] In this embodiment, a gap is left between the outer side wall of the heat conducting frame 4 and the groove wall of the reaction disc groove 11, and a gap is left between the bottom side wall of the heat conducting frame 4 and the bottom of the reaction disc groove 11, so that the liquid medium 6 can enter the above gaps to realize stable heating of the heat conducting frame 4.

[0031] In this embodiment, the connection mode of the heat conducting frame 4 relative to the reaction disc body 2 is as follows: the reaction disc body 2 is provided with a slot 21 arranged transversely corresponding to the heat conducting frame 4, and a fixing block 43 is arranged on the outer side wall of the heat conducting frame 4 and is clamped into the slot 21, so as to realize the fixed connection of the heat conducting frame 4 relative to the reaction disc body 2.

[0032] Further, a heat insulation lining plate 22 is arranged between the slot 21 and the fixing block 43. The heat insulation lining plate 22 can play a heat insulation role and avoid the heat dissipation problem caused by the heat of the heat conducting frame 4 being transferred to the reaction disc body 2 through the fixing block 43.

[0033] In another embodiment, it can also be that screw holes are arranged on the reaction disc body 2, and bolts connected to the screw holes are arranged on the heat conducting frame 4, so as to realize the connection between the reaction disc body 2 and the heat conducting frame 4; this design is not limited thereto.

[0034] In this embodiment, a convex platform 44 extending outward is arranged at the bottom of the heat conducting frame 4, so as to increase the contact volume between the heat conducting frame 4 and the liquid medium 6 and improve the heating efficiency of the liquid medium 6 on the heat conducting frame 4.

[0035] The reaction cup 3 is preferably made of quartz material, so as to have excellent heat conduction performance, effectively improve the heating rate of the reaction cup 3, and enable the temperature of the reaction cup 3 to be more stable. In actual tests, the heating time of the reaction cup 3 made of quartz material in the heating hole 41 is within 80 s, and the temperature accuracy can be controlled within 37 ± 0.1 °C.

[0036] In this embodiment, an installation portion 12 for sensor connection is arranged on the outer side groove wall of the reaction disc groove 11, and the installation portion 12 is arranged facing the light window 42.

[0037] Although the present disclosure is disclosed as above, the scope of protection of the present disclosure is not limited thereto. For those skilled in the art, various changes and modifications can be made without departing from the spirit and scope of the present disclosure, and these changes and modifications will all fall within the scope of protection of the invention.

Claims

1. A temperature control device applied to a protein analyzer, characterized in that, It includes a reaction disk base (1), a reaction disk body (2) and reaction cups (3). An annular reaction disk groove (11) with an upward-opening notch is provided on the reaction disk base (1). The reaction disk body (2) is rotatably connected to the reaction disk base (1) with the vertical direction as the axis. The reaction disk body (2) is provided with a number of heat-conducting frames (4) distributed circumferentially, and the heat-conducting frames (4) all extend into the reaction disk groove (11). The heat-conducting frames (4) are provided with upward-opening heating holes (41), and the reaction cups (3) are inserted into the heating holes (41). A light window (42) penetrating horizontally to the heating hole (41) is provided on the outer wall of the heat-conducting frame (4). A liquid medium (6) is filled in the reaction disk groove (11), the liquid medium (6) is in contact with the heat-conducting frame (4), and the liquid level of the liquid medium (6) is lower than the light window (42).

2. The temperature control device for a protein analyzer according to claim 1, characterized in that, A limit seat (5) corresponding to each heat-conducting frame (4) is further provided on the reaction disk body (2). The limit seat (5) is located above the corresponding heat-conducting frame (4), and the limit seat (5) is provided with a vertical limit hole (51). The limit hole (51) is arranged opposite to the corresponding heating hole (41). The limit hole (51) is used to limit the upper part of the reaction cup (3) so that there is a gap between the outer peripheral wall of the lower part of the reaction cup (3) and the inner peripheral wall of the heating hole (41).

3. The temperature control device for a protein analyzer according to claim 2, characterized in that, A support portion (31) is provided at the top end of the reaction cup (3). The support portion (31) is placed above the corresponding limit hole (51) so that there is a gap between the bottom side wall of the reaction cup (3) and the bottom of the heating hole (41).

4. A temperature control device applied to a protein analyzer according to any one of claims 1-3, characterized in that, There is a gap between the outer side wall of the heat-conducting frame (4) and the groove wall of the reaction disk groove (11), and there is a gap between the bottom side wall of the heat-conducting frame (4) and the groove bottom of the reaction disk groove (11).

5. The temperature control device for a protein analyzer according to claim 4, characterized in that, The reaction disk body (2) is provided with a slot (21) arranged horizontally and corresponding to the heat-conducting frame (4). A fixing block (43) is provided on the outer side wall of the heat-conducting frame (4) and is clamped into the slot (21).

6. The temperature control device applied to a protein analyzer according to claim 5, wherein An insulating lining plate (22) is provided between the slot (21) and the fixing block (43).

7. The temperature control device for a protein analyzer according to claim 4, wherein A boss (44) extending outward is provided at the bottom of the heat-conducting frame (4).

8. The temperature control device for a protein analyzer according to claim 1, wherein, The liquid medium (6) is water or oil.

9. The temperature control device applied to a protein analyzer according to claim 1, characterized in that, The reaction cup (3) is made of quartz material.

10. A temperature control device applied to a protein analyzer according to claim 1, characterized in that, An installation portion (12) for connecting a sensor is provided on the groove wall of the reaction disk groove (11), and the installation portion (12) is arranged towards the light window (42).

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