A droplet preparation system

Abstract

This invention relates to a droplet preparation system, comprising: a droplet chip for forming droplets from an aqueous phase and an oil phase; an execution unit for injecting the aqueous phase and the oil phase into the droplet chip; the execution unit includes a first actuator, a second actuator, and a syringe; the first and second actuators have identical structures, the first actuator is detachably connected to the syringe, and the second actuator is detachably connected to the syringe; the first and second actuators respectively push the syringe; a controller for controlling the operation of the execution unit and the injection speed of the aqueous and oil phases; and a photocuring device for accelerating the curing of the droplets, wherein the controller is connected to the execution unit via a signal line, the execution unit is connected to the droplet chip via a conduit, the droplet chip is connected to the photocuring device via a conduit, and the conduit is hollow, allowing liquid to pass through. This configuration enables the preparation of droplets and the photocuring of droplets with different compositions.

Description

Technical Field

[0001] This invention belongs to the field of medical device technology, specifically relating to a droplet preparation system. Background Technology

[0002] Microdroplets have important applications in drug controlled release, virus detection, particulate material synthesis, and catalysts. In the field of IVD (In Vitro Diagnostics), gene chips, protein chips, and dPCR all require the use of microdroplets. The development of microfluidics technology has enabled the controllable design and precise manipulation of the size, structure, morphology, and function of microdroplets, making it one of the most important technological platforms in the field of microdroplets.

[0003] Microfluidic methods for preparing microdroplets primarily utilize two immiscible liquids as the continuous and discrete phases, respectively. Droplet formation is controlled by manipulating the microtube structure and the flow rate ratio between the two phases. Driven by a pump with a fixed volumetric flow rate, the continuous and discrete phases enter different microchannels. When the two fluids meet at their intersection, the discrete phase continues to extend, forming a "plug-like" or "jet-like" liquid column. This column is then clamped off by the shearing and compression of the continuous phase, dispersing as microdroplets within the continuous phase.

[0004] Current droplet preparation systems suffer from problems such as unstable solidification processes in microdroplets and incomplete fusion or solidification of microspheres.

[0005] To address the above-mentioned problems, this invention provides a droplet preparation system. Summary of the Invention

[0006] To overcome the problems mentioned in the background art, the present invention adopts the following technical solution:

[0007] A droplet preparation system comprising:

[0008] Droplet chips are used to form droplets from aqueous and oil phases.

[0009] An execution unit is used to inject an aqueous phase and an oil phase into a droplet chip; the execution unit includes a first actuator, a second actuator, and a needle; the first actuator and the second actuator have the same structure, the first actuator is detachably connected to the needle, and the second actuator is detachably connected to the needle; the first actuator and the second actuator respectively push the needle connected to them;

[0010] The controller controls the operation of the actuator and the injection rates of the aqueous and oil phases;

[0011] The photopolymerization device accelerates the curing of droplets, making the curing process of microdroplets stable and complete, and preventing the microspheres from fusing together;

[0012] The controller and execution unit are connected via signal lines, the execution unit is connected to the droplet chip via a pipeline, and the droplet chip is connected to the photocuring device via a pipeline. The pipeline is hollow, and liquid flows through it. This configuration enables the preparation of droplets and the photocuring of droplets with different compositions.

[0013] Furthermore, the droplet chip is internally provided with a first channel and a second channel; the second end of the first channel and the second end of the second channel are connected and merged into a total channel; the oil phase and the water phase enter in the first channel and the second channel respectively, and form droplets in the total channel.

[0014] Furthermore, the first end of the first channel, the first end of the second channel, and the end of the main channel are all provided with connection holes, which can be used to connect pipelines.

[0015] Furthermore, the first actuator and the second actuator are respectively connected to the controller; the controller can control the advancement speed of the first actuator and the second actuator on the needle tube, which is beneficial to the formation of droplets.

[0016] Furthermore, the first actuator includes a motor, a rectangular plate, a lead screw, and a movable block; the rectangular plate includes a first plate, a second plate, and a third plate; the motor is separate from the first plate and fixedly connected to the first plate; the motor shaft is fixedly connected to the lead screw; and the movable block is movably connected to the lead screw.

[0017] Furthermore, a first through hole is provided at the center of the first plate, the second plate, and the third plate. The second plate is located between the first plate and the third plate. Second through holes are provided on both sides of the first through hole of the second plate. Two light rods are provided between the first plate and the third plate. The light rods are located on both sides of the first through hole. The diameter of the light rods is the same as the diameter of the second through hole, and the light rods pass through the second through holes.

[0018] Furthermore, the motor and the lead screw are connected by a coupling.

[0019] Furthermore, a base plate is provided at the bottom of the adjacent sides of the second and third plates, and the base plate is fixedly connected to the second and third plates respectively; the above arrangement ensures that the second plate is fixed and will not move left or right.

[0020] Furthermore, the movable block is rectangular in shape, and a first threaded hole is provided at the center of any side of the movable block. The first threaded hole is adapted to the thread on the lead screw. Third through holes are provided on both sides of the first threaded hole of the movable block. The movable block is mounted on the lead screw and the guide rod. The left and right movement of the movable block can be realized by rotating the lead screw.

[0021] Furthermore, a slot is provided at the top of the movable block, and an opening is provided on any side of the slot at the top of the movable block. The opening connects the slot to the outside, and the length of the opening is less than the length of the slot. The above arrangement ensures that the piston handle of the needle can be placed in the slot.

[0022] Furthermore, a second threaded hole is provided on the side opposite the opening on the movable block.

[0023] Furthermore, a clamping block is provided inside the slot, the thickness of the clamping block being less than the width of the slot. A threaded rod is provided on the side of the clamping block, the first end of the threaded rod being fixedly connected to the clamping block, the threaded rod being adapted to a second threaded hole, the threaded rod passing through the second threaded hole, and an operating part being provided at the second end of the threaded rod, the operating part being fixedly connected to the threaded rod, and an anti-slip layer being provided on the operating part; turning the operating part clamping part can clamp or release the piston handle.

[0024] Furthermore, a circular groove is provided at the top center of the third plate, the diameter of which is larger than the diameter of the empty syringe tube, and the empty syringe tube is placed in the circular groove.

[0025] Furthermore, a fixing plate is provided on the top of the third plate, the fixing plate spans across the circular groove, the direction of the fixing plate is perpendicular to the axis of the circular groove, a fourth through hole is provided at any end of the fixing plate, a threaded rod is provided in the through hole, a threaded hole is provided on the top of the third plate corresponding to the fourth through hole, and the threaded rod is disposed in the threaded hole on the top of the third plate. Rotating the threaded rod can clamp or loosen the needle tube.

[0026] Furthermore, the two ends of the pipeline are respectively adapted to the needle tip of the syringe and the connection hole on the droplet chip, ensuring a tight connection to prevent leakage and avoid affecting the preparation of the droplets.

[0027] Furthermore, the photocuring device includes: a pipe placement structure for placing experimental pipes and heating and controlling the temperature of the pipes; the placement length of the pipes within the pipe placement structure is adjustable; a baffle, disposed around the upper surface of the pipe placement structure and fixedly connected to the pipe placement structure, for protecting the pipes from interference from the external environment; and a light source structure, disposed on the upper part of the baffle and rotatably connected to the baffle, for providing light to the pipes to cure the droplets within the pipes. The placement length of the pipes within the pipe placement structure is adjustable, and different placement lengths of the pipe path can be selected according to the different materials of the droplets and the different photocuring times required, to ensure the effective curing of the droplets.

[0028] Furthermore, the pipeline placement structure is a rectangular plate; a receiving cavity is provided inside the pipeline placement structure, and an electric heating wire is provided inside the receiving cavity, which can heat and control the temperature of the pipeline placement structure.

[0029] Furthermore, a pipe channel is provided on the upper surface of the pipe placement structure. The pipe channel includes a straight section and a coiled section. The straight section includes a first straight section and a second straight section. The first straight section is located near the width side and is parallel to the width direction of the pipe placement structure. The length of the first straight section is half that of the pipe placement structure. The first straight section is located on the second side of the pipe placement structure and extends to the middle of the pipe placement structure. The first straight section connects the second side of the pipe placement structure and the coiled section.

[0030] Furthermore, the lower half of the cross-section of the pipeline channel is semi-circular, and the upper half of the cross-section of the pipeline channel is rectangular. The length of the rectangle is the same as the diameter of the semi-circle, and the width of the rectangle is greater than the radius of the semi-circle. The above configuration ensures that the pipeline placed in the pipeline channel will not leak out within the pipeline channel.

[0031] Furthermore, the coiled section is designed to be spirally coiled, allowing the pipeline to enter the coiled section and fully receive light irradiation to achieve droplet solidification.

[0032] Furthermore, at least two coiled sections are provided, and each coiled section is coiled in multiple turns. The inner circle of the first coiled section is connected to the second coiled section by a channel. Preferably, three coiled sections are provided, so that the required photocuring time varies depending on the material of the droplets in the pipeline, and different lengths of pipeline channels composed of one or more coiled sections can be selected.

[0033] Furthermore, the innermost ring of each of the coiled sections is connected to a second straight segment, which is parallel to the first straight segment. The second straight segment connects the innermost ring of the coiled section to the first side of the pipeline placement structure.

[0034] Furthermore, at least one baffle is provided on the pipe placement structure at the upper part of the pipe channel, and the baffle is rotatably connected to the pipe placement structure; the above arrangement can prevent the pipe from coming out of the pipe placement structure and affecting the experimental results.

[0035] Furthermore, the baffle includes a first baffle and a second baffle. The first baffle is disposed on the upper part of a first side of the pipe placement structure, and the second baffle is disposed on the upper part of other surfaces of the pipe placement structure. The first baffle and the second baffle are fixedly connected.

[0036] Furthermore, the first baffle is a transparent plate, and the second baffle is a backlight plate; the backlight plate prevents light from scattering to the outside, reducing the solidification time of the droplets, and the transparent plate is provided to facilitate observation of the droplets.

[0037] Furthermore, the light source structure includes a top cover and an illumination lamp; the illumination lamp is fixedly connected to the bottom of the top cover, and at least one illumination lamp is provided on the top cover, the illumination lamp being a long strip lamp tube. Optionally, the illumination lamp is an ultraviolet illumination lamp.

[0038] Furthermore, the top cover and the pipeline placement structure are the same in shape and size, and the top cover and the second baffle opposite to the first baffle are rotatably connected; preferably, the top cover and the second baffle opposite to the first baffle are connected by a hinge.

[0039] Furthermore, a handle is provided on the top of the cover to facilitate operation by the operator.

[0040] Furthermore, the top cover is equipped with a light control switch, a heat control switch, and a heat adjustment button.

[0041] Furthermore, a temperature sensor is installed on the upper surface of the pipeline placement structure; the temperature sensor is connected to the controller and can adjust the temperature in real time.

[0042] Furthermore, the controller is equipped with a display screen, which can be operated through the screen; the controller also includes a central controller, a data analysis module, a data storage module, and a communication module, which are respectively connected to the central controller; the information operated on the screen is transmitted to the data analysis module for analysis, and then the analysis results are transmitted to the display screen through the central controller; the usage records are effectively archived by the data storage module for easy retrieval and use later.

[0043] The beneficial effects of this invention are as follows: The invention has a reasonable structure. By connecting the execution unit to the controller, it ensures high precision in both oil and water phase injection, exhibiting high accuracy and stability. By incorporating a droplet chip, droplets can be obtained at the rear end. By setting up a photocuring device and multiple coiled segments within the pipeline channel, the pipeline can coil in a spiral shape within the channel. Furthermore, depending on the material of the droplet and the required photocuring time, the pipeline path can be selected using pipeline channels of different lengths composed of single or multiple coiled segments to ensure effective droplet curing. Attached Figure Description

[0044] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0045] Figure 2 This is a schematic diagram of the structure of the first actuator and the needle tube of the present invention.

[0046] Figure 3 This is a schematic diagram of the structure of the first actuator of the present invention;

[0047] Figure 4This is a schematic diagram of the structure connecting the droplet chip and the pipeline of the present invention;

[0048] Figure 5 This is a schematic diagram of the droplet chip structure of the present invention;

[0049] Figure 6 This is a schematic diagram of the structure of the photocuring device of the present invention when the top cover is open;

[0050] Figure 7 This is a schematic diagram of the structure of the photocuring device of the present invention when the top cover is closed;

[0051] Figure 8 This is a schematic diagram of the pipe placement structure and the cooperation of the baffle in this invention;

[0052] Figure 9 This is a top view schematic diagram of the pipe placement structure and the baffle cooperation of the present invention;

[0053] Figure 10 This is a schematic diagram of the bottom surface of the light source structure of the present invention;

[0054] Figure 11 This is a schematic diagram of the upper surface of the light source structure of the present invention;

[0055] In the diagram, 1. Droplet chip; 2. First channel; 3. Second channel; 4. Main channel; 5. Connecting hole; 6. Needle; 7. Motor; 8. First plate; 9. Second plate; 10. Third plate; 11. Base plate; 12. Lead screw; 13. Groove; 14. Clamping block; 15. Movable block; 16. Operating part; 17. Circular groove; 18. Fixing plate; 19. Controller; 20. Pipeline placement structure; 21. First straight segment; 22. Second straight segment; 23. Coiled segment; 24. Baffle; 25. First baffle; 26. Second baffle; 27. Top cover; 28. Illumination lamp; 29. ​​Handle; 30. Light control switch; 31. Heat control switch; 32. Heat adjustment button; 33. Pipeline. Detailed Implementation

[0056] The technical solutions of the embodiments of the present invention are clearly and completely described below through specific examples. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0057] Example 1

[0058] Please refer to Figure 1-11 This embodiment provides a droplet preparation system, comprising: a droplet chip 1 for forming droplets from an aqueous phase and an oil phase; an execution unit for injecting the aqueous and oil phases into the droplet chip 1; a controller 19 for controlling the operation of the execution unit and the injection speed of the aqueous and oil phases; and a photocuring device for accelerating the curing of the droplets, ensuring a stable and complete curing process, and preventing the microspheres from fusing together. The controller 19 is connected to the execution unit via a signal line, the execution unit is connected to the droplet chip 1 via a conduit 33, and the droplet chip 1 is connected to the photocuring device via the conduit 33. The conduit 33 is hollow, allowing liquid to pass through it. This configuration enables the preparation of droplets and the photocuring of droplets with different compositions.

[0059] The droplet chip 1 has a first channel 2 and a second channel 3 inside; the second end of the first channel 2 and the second end of the second channel 3 are connected and merged into a total channel 4; the oil phase and the water phase enter in the first channel 2 and the second channel 3 respectively, and form droplets in the total channel 4. Preferably, the first segment of the first channel 2 is a straight line, the second segment of the first channel 2 is rectangular, the second channel 3 is inside the second segment of the first channel 2, and the total channel 4 is set outside the intersection of the first channel 2 and the second channel 3.

[0060] Connection holes 5 are provided at the first end of the first channel 2, the first end of the second channel 3, and the end of the main channel 4. Connection holes 5 can be used to connect pipelines.

[0061] The execution unit includes a first actuator, a second actuator, and a needle tube 6; the first actuator and the second actuator have the same structure, the first actuator is detachably connected to the needle tube 6, and the second actuator is detachably connected to the needle tube 6; the first actuator and the second actuator are respectively connected to the controller 19; the controller 19 can control the pushing speed of the first actuator and the second actuator on the needle tube 6, which is beneficial to the formation of droplets.

[0062] The first actuator includes a motor 7, a rectangular plate, a lead screw 12, and a movable block 15; the rectangular plate includes a first plate 8, a second plate 9, and a third plate 10. The motor 7 is separate from the first plate 8 and fixedly connected to the first plate 8. The shaft of the motor 7 is fixedly connected to the lead screw 12, and the movable block 15 is movably connected to the lead screw 12.

[0063] A first through hole is provided at the center of the first plate 8, the second plate 9 and the third plate 10. The second plate 9 is located between the first plate 8 and the third plate 10. Second through holes are provided on both sides of the first through hole of the second plate 9. Two light rods are provided between the first plate 8 and the third plate 10. The light rods are located on both sides of the first through hole. The diameter of the light rods is the same as the diameter of the second through hole. The light rods pass through the second through holes.

[0064] The motor 7 and the lead screw 12 are connected by a coupling.

[0065] A base plate 11 is provided at the bottom of the adjacent sides of the second plate 9 and the third plate 10. The base plate 11 is fixedly connected to the second plate 9 and the third plate 10 respectively. The above arrangement ensures that the second plate 9 is fixed and will not move left or right.

[0066] The movable block 15 is rectangular in shape. A first threaded hole is provided at the center of any side of the movable block 15. The first threaded hole is adapted to the thread on the lead screw 12. A third through hole is provided on both sides of the first threaded hole of the movable block 15. The movable block 15 is set on the lead screw 12 and the guide rod. The left and right movement of the movable block 15 can be realized by rotating the lead screw 12.

[0067] A slot 13 is provided at the top of the movable block 15, and an opening is provided on any side of the slot 13 at the top of the movable block 15. The opening connects the slot 13 to the outside. The length of the opening is less than the length of the slot 13. The above arrangement ensures that the piston handle of the needle tube 6 can be placed in the slot 13.

[0068] A second threaded hole is provided on the opposite side of the movable block 15.

[0069] A clamping block 14 is provided inside the slot 13. The thickness of the clamping block 14 is less than the width of the slot 13. A threaded rod is provided on the side of the clamping block 14. The first end of the threaded rod is fixedly connected to the clamping block 14. The threaded rod is adapted to the second threaded hole and passes through the second threaded hole. An operating part 16 is provided at the second end of the threaded rod. The operating part 16 is fixedly connected to the threaded rod and has an anti-slip layer. Tightening the operating part 16 can clamp or loosen the piston handle.

[0070] A circular groove 17 is provided at the top center of the third plate 10. The diameter of the circular groove 17 is larger than the diameter of the empty cylinder of the syringe 6. The empty cylinder of the syringe 6 is placed in the circular groove 17. When working, the lead screw 12 rotates and the movable block 15 moves back and forth along the lead screw 12. The movable block 15 pushes the piston handle to move and inject the liquid in the syringe 6 into the pipeline 33.

[0071] A fixing plate 18 is provided on the top of the third plate 10. The fixing plate 18 spans across the circular groove 17. The direction of the fixing plate 18 is perpendicular to the axis of the circular groove 17. A fourth through hole is provided at any end of the fixing plate 18. A threaded rod is provided in the through hole. A threaded hole is provided on the top of the third plate 10 corresponding to the fourth through hole. The threaded rod is disposed in the threaded hole on the top of the third plate 10. Rotating the threaded rod can clamp or loosen the needle tube 6.

[0072] The two ends of the tube 33 are respectively adapted to the needle of the needle tube 6 and the connection hole 5 on the droplet chip 1, ensuring that the connection is tight and there will be no leakage, thus avoiding affecting the preparation of the droplet.

[0073] like Figure 6-11The photocuring apparatus includes: a tubing placement structure 20 for placing experimental tubing and heating it to control its temperature; the length of the tubing within the tubing placement structure 20 is adjustable; a baffle, fixedly connected to the tubing placement structure 20 and positioned around its upper surface, to protect the tubing from external environmental interference; and a light source structure located above the baffle, providing light to the tubing to cure the droplets within it. The adjustable length of the tubing within the tubing placement structure 20 allows for selection of different placement lengths based on the material of the droplets and the required photocuring time, ensuring optimal curing results.

[0074] The pipe placement structure 20 is a rectangular plate; the pipe placement structure 20 has an internal cavity, and an electric heating wire is installed inside the cavity. The electric heating wire can heat and control the temperature of the pipe placement structure 20; the electric heating wire can heat the upper part of the pipe placement structure 20 to a temperature of 35-70 degrees.

[0075] In some embodiments, the pipeline placement structure 20 is configured as an adjustable temperature heating plate, which can achieve temperature regulation; the adjustable temperature heating plate can be selected from existing technologies.

[0076] The upper surface of the pipe placement structure 20 is provided with a pipe channel, which includes a straight section and a coiled section 23. The straight section includes a first straight section 21 and a second straight section 22. The first straight section 21 is located near the width side and is parallel to the width direction of the pipe placement structure 20. The length of the first straight section 21 is half of the length of the pipe placement structure 20. The first straight section 21 is located on the second side of the pipe placement structure 20 and extends to the middle of the pipe placement structure 20. The first straight section 21 connects the second side of the pipe placement structure 20 and the coiled section 23.

[0077] In some embodiments, the lower half of the cross-section of the pipeline channel is semi-circular, and the upper half of the cross-section is rectangular. The length of the rectangle is the same as the diameter of the semi-circle, and the width of the rectangle is greater than the radius of the semi-circle. This arrangement ensures that the pipeline placed inside the pipeline channel will not leak out, preventing the pipeline from detaching and causing uncertainty in the length of the pipeline within the pipeline placement structure 20, which would affect the experiment. At least one baffle 24 is provided on the pipeline placement structure 20 at the upper part of the pipeline channel, and the baffle 24 is rotatably connected to the pipeline placement structure 20. This arrangement can prevent the pipeline from detaching from the pipeline placement structure 20 and affecting the experimental results. In some embodiments, the baffle 24 is fixedly connected to the pipeline placement structure 20 and spans across the pipeline channel to prevent the pipeline from detaching from the pipeline channel.

[0078] In some embodiments, the lower half of the cross-section of the pipeline channel is semi-circular, and the upper half of the cross-section of the pipeline channel is rectangular. The length of the rectangle is the same as the diameter of the semi-circle, and the width of the rectangle is greater than the radius of the semi-circle. A transparent plate is provided on the upper part of the pipeline channel, which completely covers the pipeline channel and can confine the pipeline within the pipeline channel, ensuring that the length of the pipeline within the pipeline channel is fixed and the light exposure time is fixed, which is conducive to the solidification of droplets.

[0079] In some embodiments, the cross-section of the pipeline channel is an arc shape, the pipeline extends into the first straight segment 21 and can move along the pipeline channel, and the upper width of the pipeline channel is smaller than the diameter of the pipeline channel, ensuring that the pipeline will not come out at the upper part of the pipeline channel.

[0080] The coiled section 23 is designed to be spirally coiled, allowing the pipeline to enter the coiled section 23 and fully receive light irradiation to achieve droplet solidification.

[0081] At least two coiled sections 23 are provided, and the coiled sections 23 are coiled in multiple turns. The inner circle of the first coiled section is connected to the second coiled section by a channel. Preferably, three coiled sections 23 are provided, so that the required light curing time is different depending on the material of the droplets in the pipeline. Then, the pipeline channel of different lengths composed of one or more coiled sections 23 can be selected.

[0082] like Figure 6 8-9 In some embodiments, the first coiled segment 23 is a counterclockwise spiral coiled segment. A channel connecting to the second coiled segment 23 is provided on the upper right side of the innermost circle of the coiled segment 23. The channel is tangent to the connection point of the first coiled segment 23, allowing the pipeline to smoothly enter the second coiled segment 23 within the channel. The second coiled segment 23 is a clockwise spiral coiled segment. A channel connecting to the third coiled segment 23 is provided on the upper right side of the innermost circle of the coiled segment 23. The channel is tangent to the connection point of the second coiled segment 23, allowing the pipeline to smoothly enter the third coiled segment 23 within the channel. The coiling direction of the third coiled segment 23 is the same as that of the second coiled segment 23.

[0083] In some embodiments, the first coiled segment 23 is a clockwise spiral coiled segment, and a channel connecting to the second coiled segment 23 is provided on the upper right side of the innermost circle of the coiled segment 23. The channel is tangent to the connection point of the first coiled segment 23, allowing the pipe to smoothly enter the second coiled segment 23 within the channel. The second coiled segment 23 is a counterclockwise spiral coiled segment, and a channel connecting to the third coiled segment 23 is provided on the upper right side of the innermost circle of the coiled segment 23. The channel is tangent to the connection point of the second coiled segment 23, allowing the pipe to smoothly enter the third coiled segment 23 within the channel. The coiling direction of the third coiled segment 23 is the same as that of the second coiled segment 23.

[0084] The innermost end of the coiled section 23 is connected to the second straight section 22. The second straight section 22 is parallel to the first straight section 21. The second straight section 22 connects the innermost ring of the coiled section 23 and the first side of the pipe placement structure 20.

[0085] In some embodiments, the coiled segment 23 is configured as a wave groove, with a straight middle section and arc-shaped ends. The length of the wave groove is slightly less than the length between two opposing baffles, and the distance between the two midpoints of the wave groove is greater than the width of the wave groove itself.

[0086] The baffle includes a first baffle 25 and a second baffle 26. The first baffle 25 is disposed on the upper part of the first side of the pipe placement structure 20, and the second baffle 26 is disposed on the upper part of the other side of the pipe placement structure 20. The first baffle 25 and the second baffle 26 are fixedly connected.

[0087] The first baffle 25 is a transparent plate, and the second baffle 26 is a backlight plate; the backlight plate prevents light from scattering to the outside and reduces the solidification time of the droplets, while the transparent plate is set up to facilitate the observation of the droplets.

[0088] like Figure 6-7 10-11, The light source structure includes a top cover 27 and an irradiation lamp 28; the irradiation lamp 28 is fixedly connected to the bottom of the top cover 27, and at least one irradiation lamp 28 is provided on the top cover 27, the irradiation lamp 28 being a long strip lamp tube. Optionally, the irradiation lamp 28 is an ultraviolet irradiation lamp 28; the light from the irradiation lamp 28 can be light particles or light beams. The basic principle of ultraviolet curing is to use ultraviolet light to irradiate the material, causing it to undergo a photochemical reaction, thereby achieving a rapid curing process. Under ultraviolet irradiation, the double or triple bonds in the material will break down, forming free radicals or ions. These free radicals or ions will react with surrounding molecules to form a cross-linked structure, thereby achieving the curing process.

[0089] In some embodiments, the illumination lamps 28 are configured as circular or square, and the illumination lamps 28 are evenly distributed inside the top cover 27 to ensure that the light intensity is the same at any position on the upper surface of the pipeline placement structure 20, which is beneficial to the experiment.

[0090] The top cover 27 and the pipeline placement structure 20 are the same in shape and size. The top cover 27 and the second baffle 26 opposite to the first baffle 25 are rotatably connected. Preferably, the top cover 27 and the second baffle 26 opposite to the first baffle 25 are connected by a hinge.

[0091] The top cover 27 is equipped with a handle 29, which makes it convenient for operators to open and operate the interior.

[0092] The top cover 27 is equipped with a light control switch 30, a heat control switch 31, and a heat adjustment button 32.

[0093] A temperature sensor is installed on the upper surface of the pipeline placement structure 20; the temperature sensor is connected to the controller 19 and can adjust the temperature in real time; the controller 19 is connected to the illumination lamp 28 and can control the light intensity of the illumination lamp 28. The controller 19 can adjust the temperature of the heating wire and can obtain the temperature information from the temperature sensor to achieve feedback regulation.

[0094] In some embodiments, the controller 19 may be replaced by a rheostat, which is used to change the temperature of the heating wire.

[0095] In some embodiments, multiple switches for the illumination lamps 28 are provided, the number of which is the same as the number of coiled segments 23. Each switch controls a portion of the illumination lamps 28 on the upper part of a coiled segment 23. Depending on the material of the droplet, the required photocuring time is different. The path of the pipeline is selected through pipeline channels of different lengths composed of one or more coiled segments 23. At the same time, the corresponding switches are turned on to illuminate the corresponding coiled segments 23. The used coiled segments 23 are illuminated, while the unused coiled segments 23 are not illuminated.

[0096] The controller 19 includes a central controller 19, a data analysis module, a data storage module, and a communication module. The data analysis module, data storage module, and communication module are respectively connected to the central controller 19. The operation information is transmitted to the data analysis module for analysis, and then the analysis results are transmitted to the illumination lamp 28 and the heating wire for control through the central controller 19. The data storage module is used to effectively archive the usage records for easy retrieval and use next time.

[0097] In some embodiments, a collection bottle is connected to the rear end of the photocuring device.

[0098] In some embodiments, the controller 19 can be connected to a computer via USB and operated through a computer control interface; a touch screen or computer graphical interface can be used to control or monitor the device.

[0099] Alternatively, in some embodiments, the interior of the pipe placement structure 20 is solid, and heating wires are arranged around the pipe placement structure 20 for heating. The interior of the pipe placement structure 20 has a three-dimensional spiral channel through which the pipe can pass. A dot-shaped irradiation lamp 28 is arranged inside the spiral channel for light irradiation to achieve the conditions for photocuring. Multiple outlets are provided at the upper part of the spiral channel, and the length of the pipe passing through the interior is marked at each outlet. The path of the pipe can be selected according to the different materials of the droplets and the different photocuring times required.

[0100] In use, first connect the droplet chip 1, the execution unit, and the photocuring device using the pipeline 33. Then, set the flow rate on the computer interface or the display screen of the controller 19. Depending on the material of the droplet, the required photocuring time will vary. Select a pipeline path that consists of a single or multiple coiled sections 23 of different lengths. Then, extend the pipeline into the pipeline channel, passing through the first straight section 21, the coiled section 23, and the second straight section 22 in sequence, and finally extend it out in the second telescopic section. Turn on the internal heating wire and adjust it to a suitable temperature. Turn on the corresponding irradiation lamp 28. Finally, press the run button to prepare the droplet.

[0101] The above description of the embodiments is only for understanding the present invention. It should be noted that those skilled in the art can make several modifications to the present invention without departing from the principles of the invention, and these modifications will also fall within the protection scope of the claims of the present invention.

Claims

1. A droplet preparation system, characterized in that, It includes: Droplet chips are used to form droplets from aqueous and oil phases. An execution unit is used to inject aqueous and oil phases into the droplet chip; The execution unit includes a first actuator, a second actuator, and a needle tube; the first actuator and the second actuator have the same structure, the first actuator is detachably connected to the needle tube, and the second actuator is detachably connected to the needle tube; the first actuator and the second actuator respectively push the needle tube connected to them; The controller controls the operation of the actuator and the injection rates of the aqueous and oil phases; A photocuring device accelerates the curing of droplets, ensuring a stable and complete curing process without the microdroplets fusing together. The device includes a pipe placement structure for holding experimental tubing and for heating and temperature control of the tubing. The length of the tubing within the placement structure is adjustable. A pipe channel is provided on the upper surface of the placement structure, comprising a straight section and a coiled section. The straight section includes a first straight section and a second straight section. The first straight section is located near the width edge and is parallel to the width direction of the placement structure. The first straight section connects the second side of the placement structure to the coiled section. At least two coiled sections are provided, each coiled multiple times. The innermost loop of the first coiled section is connected to the second coiled section via a channel. The innermost loop of each coiled section connects to the second straight section, which is parallel to the first straight section and connects the innermost loop of the coiled section to the first side of the placement structure. The controller and the execution unit are connected via signal lines, the execution unit and the droplet chip are connected via pipelines, and the droplet chip is connected to the photocuring device via pipelines. The pipelines are hollow, and liquid flows through them.

2. The droplet preparation system according to claim 1, characterized in that, The droplet chip has a first channel and a second channel inside; the second end of the first channel and the second end of the second channel are connected to merge into a total channel; the first end of the first channel, the first end of the second channel and the end of the total channel are all provided with connection holes.

3. The droplet preparation system according to claim 1, characterized in that, The first actuator and the second actuator are respectively connected to the controller.

4. The droplet preparation system according to claim 3, characterized in that, The first actuator includes a motor, a rectangular plate, a lead screw, and a movable block; the rectangular plate includes a first plate, a second plate, and a third plate; the motor is separate from the first plate and fixedly connected to the first plate; the motor shaft is fixedly connected to the lead screw; the movable block is movably connected to the lead screw; the second plate is disposed between the first plate and the third plate; two guide rods are disposed between the first plate and the third plate; the motor and the lead screw are connected by a coupling; the movable block is rectangular in shape, and a first threaded hole is disposed at the center of any side of the movable block, the first threaded hole being adapted to the thread on the lead screw; the movable block is disposed on the lead screw and the guide rods.

5. The droplet preparation system according to claim 4, characterized in that, The movable block has a slot at its top, and an opening on either side of the slot. A second threaded hole is provided on the side of the movable block opposite to the opening. A clamping block is provided inside the slot, and a threaded rod is provided on the side of the clamping block. The first end of the threaded rod is fixedly connected to the clamping block, and the threaded rod is adapted to the second threaded hole. The threaded rod passes through the second threaded hole, and an operating part is provided at the second end of the threaded rod. The operating part is fixedly connected to the threaded rod, and an anti-slip layer is provided on the operating part.

6. The droplet preparation system according to claim 4, characterized in that, A circular groove is provided at the top center of the third plate, and a fixing plate is provided at the top of the third plate. The fixing plate spans across the circular groove, and the fixing plate and the third plate are movably connected.

7. The droplet preparation system according to claim 1, characterized in that, The photocuring device also includes baffles, which are disposed around the upper surface of the pipeline placement structure. The baffles are fixedly connected to the pipeline placement structure to protect the pipeline from interference by the external environment. A light source structure is disposed on the upper part of the baffles and is rotatably connected to the baffles.

8. The droplet preparation system according to claim 7, characterized in that, The pipe placement structure is equipped with heating wires.

9. The droplet preparation system according to any one of claims 7-8, characterized in that, The light source structure includes a top cover and an illumination lamp; the illumination lamp is fixedly connected to the bottom of the top cover, and at least one illumination lamp is provided on the top cover.

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