RTP aseptic valve tank discharge temporary storage automatic transfer and discharging device and method

Abstract

The application discloses a kind of RTP sterile valve tank discharging temporary storage automatic transfer discharging device and method, including horizontal cleaning machine, be set in the sterile isolator of horizontal cleaning machine side portion and material tank, the main valve mouth of sterile isolator is inclined downward and is set, material tank is equipped with auxiliary valve, still include fixed hoist, transfer trolley, transport mechanism and rotary turnover hoist, transfer trolley is used to send material tank to rotary turnover hoist or carry away material tank, fixed hoist is set below sterile isolator, transport mechanism is set between rotary turnover hoist and fixed hoist and is used to transport material tank set on rotary turnover hoist to fixed hoist, main valve mouth of sterile isolator is equipped with sterile adjustable butt joint mechanism for the butt joint of auxiliary valve on material tank and main valve mouth on sterile isolator.The application can realize the closed transfer of rubber plug, ensure the sterility of transfer process, avoid cross infection, meet the more stringent requirements of new version GMP to sterility.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pharmaceutical equipment, in particular to an RTP sterile valve tank outfeed temporary storage automatic transfer and discharging device and method. BACKGROUND

[0002] With the internationalization of some pharmaceutical enterprises, the requirements for pharmaceutical sterility are higher, and the new version of GMP has more stringent requirements for sterility. The packaging, transfer, and storage of the outfeed of the rubber stopper and aluminum cap after cleaning and sterilization by the cleaning machine have more stringent requirements.

[0003] At present, the barrel transfer mode of the outfeed of the horizontal drum type rubber stopper cleaning machine mainly uses ORABS, commonly used sealed open barrel or conical barrel, mobile laminar flow vehicle (ORABS), and the like to form a sterile barrel outfeed transfer system. The disadvantage of this transfer mode is that for rubber stoppers with high requirements, the sealing of the barrel has the risk of leakage, and it is difficult to ensure the sterility during the entire process. SUMMARY

[0004] The purpose of the present application is to provide an RTP sterile valve tank outfeed temporary storage automatic transfer and discharging device and method, which can realize closed transfer of rubber stoppers, ensure the sterility of the transfer process, avoid cross infection, and meet the more stringent requirements of the new version of GMP for sterility.

[0005] To achieve the above purpose, the present application provides the following technical scheme: an RTP sterile valve tank outfeed temporary storage automatic transfer and discharging device, comprising a horizontal cleaning machine, a sterile isolator arranged on the side of the horizontal cleaning machine, and a tank, wherein the main valve port of the sterile isolator is arranged in an inclined downward manner, the tank is provided with a secondary valve, and further comprising a fixed elevator, a transfer trolley, a transportation mechanism, and a rotary overturning elevator, the transfer trolley is used to transport the tank to the rotary overturning elevator or to carry away the tank, the fixed elevator is arranged below the sterile isolator, the transportation mechanism is arranged between the rotary overturning elevator and the fixed elevator and is used to transport the tank arranged on the rotary overturning elevator to the fixed elevator, and the main valve port of the sterile isolator is provided with a sterile adjustable butt joint mechanism for butt joint of the secondary valve on the tank with the main valve port on the sterile isolator.

[0006] The present application is further provided as follows: the sterile adjustable butt joint mechanism comprises an outer pressure ring, an inner pressure ring, a silica gel sleeve, a butt joint clamp, and a limiting handle assembly, the outer edge and the inner edge of the silica gel sleeve are connected to the outer pressure ring and the inner pressure ring respectively, the butt joint clamp is rotationally connected to the inner pressure ring, and the limiting handle assembly is connected between the inner pressure ring and the outer pressure ring for changing the axial position of the inner pressure ring relative to the outer pressure ring.

[0007] The application is further provided with the limiting handle assembly, which comprises a connecting plate, a limiting sleeve and an operating handle, one end of the connecting plate is connected to the inner pressing ring, the other end of the connecting plate is provided with a through hole, one end of the limiting sleeve is connected to the outer pressing ring, and the limiting sleeve penetrates through the through hole, the side of the limiting sleeve is provided with an axial guide hole extending along the axial direction, one end of the axial guide hole close to the outer pressing ring is provided with a circumferential guide hole extending along the circumferential direction, the axial guide hole and the circumferential guide hole are connected into an L-shaped guide hole, the operating handle penetrates through the limiting sleeve, and the part of the operating handle in the limiting sleeve is provided with a guide piece along the radial direction, the guide piece is arranged on the side of the connecting plate away from the outer pressing ring, and the guide piece penetrates through the L-shaped guide hole.

[0008] The application is further provided with the connecting plate, which comprises a connecting part, a swing part and a movable part, the connecting part is installed on the inner pressing ring, the swing part is arranged to be inclined away from the outer pressing ring, and the through hole is arranged on the movable part.

[0009] The application is further provided with the gasket arranged on the outer periphery of the limiting sleeve and between the guide piece and the movable part.

[0010] The application is further provided with the screw rod arranged on the outer pressing ring, one end of the limiting sleeve is threadedly connected with the screw rod, and the guide piece is a screw which is threadedly connected to the side of the operating handle.

[0011] The application is further provided with the rotating and overturning lifting machine, which comprises a first driving motor, an output end of the first driving motor is connected with a rotating base through gear transmission, the rotating base is provided with a lifting fixing frame, the top of the lifting fixing frame is provided with a second driving motor, a first screw rod is connected with the motor shaft of the second driving motor in linkage, a lifting seat is connected with the first screw rod in linkage, two sides of the lifting seat are respectively connected with pulleys in rotation, the two inner sides of the lifting fixing frame are respectively provided with one limiting guide rail matched with the pulley, the lifting seat is further connected with a first connecting block in linkage, the two sides of the first connecting block are provided with first guide grooves extending along the vertical direction in staggered arrangement, the lifting fixing frame is provided with a first guide plate matched with the first guide grooves, a third driving motor is installed on the first connecting block, an overturning frame is connected with the output end of the third driving motor in linkage, and one first telescopic rod is installed on each end of the overturning frame.

[0012] The application is further provided with the fixed lifting machine, which comprises a lifting mounting frame, a fourth driving motor is arranged at the bottom of the lifting mounting frame, a second screw is connected with the motor shaft of the fourth driving motor, a lifting frame is connected with the second screw, two vertically extending guide holes are arranged on the lifting frame, two guide rods matched with the guide holes are arranged on the lifting frame, a second connecting block is further connected with the lifting frame, vertically extending second guide grooves are arranged on the two sides of the second connecting block in a staggered manner, a second guide plate matched with the second guide grooves is arranged on the lifting mounting frame, a supporting arm is arranged on the second connecting block, and a second telescopic rod is arranged on each end of the supporting arm and inserted into a corresponding positioning sleeve.

[0013] The application is further provided with the transport mechanism, which comprises a transport track and a transport trolley slidingly arranged on the transport track, and a first supporting frame is arranged on each side of the transport trolley, a first positioning recess for embedding a corresponding positioning block is arranged in the middle of the first supporting frame, a second supporting frame is arranged on each side of the transport trolley, and a second positioning recess for embedding a corresponding positioning block is arranged in the middle of the second supporting frame.

[0014] The application also provides a method for automatically transferring and discharging the material in the RTP sterile valve tank, which comprises the following steps:

[0015] a. sterilizing the material tank by using the horizontal cleaning machine;

[0016] b. moving the material tank to the rotary overturning lifting machine by using the transfer trolley, and abutting the first telescopic rod on the rotary overturning lifting machine to the positioning sleeve on the material tank;

[0017] c. moving the material tank on the rotary overturning lifting machine to the fixed lifting machine by using the transport trolley, and abutting the second telescopic rod on the fixed lifting machine to the positioning sleeve on the material tank;

[0018] d. starting the fixed lifting machine to lift the material tank to a set height, adjusting the limiting handle assembly on the sterile adjustable abutting mechanism to ensure that the auxiliary valve on the material tank is abutted to the main valve port on the sterile isolator at this time, when the main valve port on the sterile isolator is abutted to the auxiliary valve from bottom to top, the guide piece is clamped below the L-shaped guide hole of the limiting sleeve, so that the inner and outer rings of the silica gel sleeve are closer, and the silica gel sleeve is arched; when the auxiliary valve enters the clamping groove of the main valve port, the operator pushes the operating handle a little upward and rotates the guide piece to the axial guide hole of the L-shaped guide hole, releases the handle, and uses the weight of the main valve to make the main valve port completely cover the auxiliary valve;

[0019] e. the operator operates the main valve in the sterile isolator by using gloves, opens the main valve, puts the discharging hopper into the main valve port, opens the horizontal cleaning machine to discharge, visually checks the position of the rubber plug, and stops discharging;

[0020] f, after discharging, the hopper is taken out, the main valve is closed, the fixed elevator is started, the tank is placed on the transport trolley and transported to the original position.

[0021] Compared with the prior art, the present application has the following beneficial effects:

[0022] 1. The sterile adjustable docking mechanism ensures that the auxiliary valve on the tank and the main valve port on the sterile isolator are docked well. The mechanism uses L-shaped slot rotation clamping and connecting plate combination to solve the problem of the main valve's inability to position the docking port due to gravity sagging. The design is ingenious and simple, and convenient to use.

[0023] 2. After docking, manual assistance is provided to lower the main valve and auxiliary valve of the sterile valve, which is automatically docked by gravity, which is very convenient.

[0024] 3. The entire process of transferring and docking with the PTP valve on the filling line is completely sealed and positively transferred, avoiding cross contamination and ensuring that the new version of GMP requires higher sterility for special rubber plugs. BRIEF DESCRIPTION OF DRAWINGS

[0025] Figure 1 is a schematic diagram of the structure of the whole application;

[0026] Figure 2 is a schematic diagram of the structure of the sterile adjustable docking mechanism of the application;

[0027] Figure 3 is a schematic diagram of the structure of the tank of the application;

[0028] Figure 4 is a schematic diagram of the structure of the rotary overturning elevator of the application;

[0029] Figure 5 is a schematic diagram of the transmission structure of the rotary overturning elevator of the application;

[0030] Figure 6 is a schematic diagram of the rotary overturning elevator of the application;

[0031] Figure 7 is a schematic diagram of the structure of the fixed elevator of the application;

[0032] Figure 8 is a schematic diagram of the transmission structure of the fixed elevator of the application.

[0033] In the figure: 1, horizontal cleaning machine; 2, sterile isolator; 3, material tank; 4, main valve port; 5, auxiliary valve; 6, fixed lifting machine; 7, transfer trolley; 8, transport mechanism; 9, rotary overturning lifting machine; 10, sterile adjustable butt joint mechanism; 11, outer pressure ring; 12, inner pressure ring; 13, silica gel sleeve; 14, butt joint clamp; 15, limiting handle assembly; 16, connecting plate; 17, limiting clamping sleeve; 18, operation handle; 19, through hole; 20, axial guide hole; 21, circumferential guide hole; 22, L-shaped guide hole; 23, guide piece; 24, connecting part; 25, swing part; 26, movable part; 27, gasket; 28, screw rod; 29, first driving motor; 30, rotary base; 31, lifting fixing frame; 32, second driving motor; 33, first lead screw; 34, lifting seat; 35, pulley; 36, limiting guide rail; 37, first connecting block; 38, first guide groove; 39, first guide plate; 40, third driving motor; 41, overturning frame; 42, first telescopic rod; 43, positioning block; 44, positioning sleeve; 45, lifting mounting frame; 46, fourth driving motor; 47, second lead screw; 48, lifting frame; 49, guide hole; 50, guide rod; 51, second connecting block; 52, second guide groove; 53, second guide plate; 54, support arm; 55, second telescopic rod; 56, transport track; 57, transport trolley; 58, first support frame; 59, first positioning recess; 60, second support frame; 61, second positioning recess. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0035] Embodiment: as shown in the accompanying drawings Figures 1-8The device is characterized in that the main valve port (4) of the sterile isolator (2) is arranged in an inclined downward manner, the sterile isolator (2) mainly comprises an isolator body, an RTP sterile valve, a VHP generator, a dehumidification and sterilization device, and an aeration sealing ring, the material tank (3) is provided with a secondary valve (5), and the material tank (3) comprises a Y-shaped elbow assembly, a barrel body, an RTP valve, a breather, an electric push rod mechanism, and a butterfly valve.

[0036] As shown in the accompanying drawings, the sterile adjustable docking mechanism (10) comprises an outer pressure ring (11), an inner pressure ring (12), a silica gel sleeve (13), a docking clamp (14), and a limiting handle assembly (15), the outer edge and the inner edge of the silica gel sleeve (13) are connected to the outer pressure ring (11) and the inner pressure ring (12) respectively, the docking clamp (14) is rotationally connected to the inner pressure ring (12), and the limiting handle assembly (15) is connected between the inner pressure ring (12) and the outer pressure ring (11) for changing the axial position of the inner pressure ring (12) relative to the outer pressure ring (11). Figure 2 As shown in the accompanying drawings, the limiting handle assembly (15) comprises a connecting plate (16), a limiting clamping sleeve (17), and an operating handle (18), one end of the connecting plate (16) is connected to the inner pressure ring (12), the other end of the connecting plate (16) is provided with a through hole (19), one end of the limiting clamping sleeve (17) is connected to the outer pressure ring (11), and the limiting clamping sleeve (17) penetrates through the through hole (19), the side of the limiting clamping sleeve (17) is provided with an axially extending axial guide hole (20), one end of the axial guide hole (20) close to the outer pressure ring (11) is provided with a circumferentially extending circumferential guide hole (21), the axial guide hole (20) and the circumferential guide hole (21) are connected into an L-shaped guide hole (22), the operating handle (18) penetrates through the limiting clamping sleeve (17), and the part of the operating handle (18) located in the limiting clamping sleeve (17) is provided with a guide piece (23) in a radial direction, the guide piece (23) is arranged on the side of the connecting plate (16) away from the outer pressure ring (11), and the guide piece (23) penetrates through the L-shaped guide hole (22).

[0037] Figure 2 As shown in the accompanying drawings, the limiting handle assembly (15) comprises a connecting plate (16), a limiting clamping sleeve (17), and an operating handle (18), one end of the connecting plate (16) is connected to the inner pressure ring (12), the other end of the connecting plate (16) is provided with a through hole (19), one end of the limiting clamping sleeve (17) is connected to the outer pressure ring (11), and the limiting clamping sleeve (17) penetrates through the through hole (19), the side of the limiting clamping sleeve (17) is provided with an axially extending axial guide hole (20), one end of the axial guide hole (20) close to the outer pressure ring (11) is provided with a circumferentially extending circumferential guide hole (21), the axial guide hole (20) and the circumferential guide hole (21) are connected into an L-shaped guide hole (22), the operating handle (18) penetrates through the limiting clamping sleeve (17), and the part of the operating handle (18) located in the limiting clamping sleeve (17) is provided with a guide piece (23) in a radial direction, the guide piece (23) is arranged on the side of the connecting plate (16) away from the outer pressure ring (11), and the guide piece (23) penetrates through the L-shaped guide hole (22).

[0038] As shown in the accompanying drawings, the limiting handle assembly (15) comprises a connecting plate (16), a limiting clamping sleeve (17), and an operating handle (18), one end of the connecting plate (16) is connected to the inner pressure ring (12), the other end of the connecting plate (16) is provided with a through hole (19), one end of the limiting clamping sleeve (17) is connected to the outer pressure ring (11), and the limiting clamping sleeve (17) penetrates through the through hole (19), the side of the limiting clamping sleeve (17) is provided with an axially extending axial guide hole (20), one end of the axial guide hole (20) close to the outer pressure ring (11) is provided with a circumferentially extending circumferential guide hole (21), the axial guide hole (20) and the circumferential guide hole (21) are connected into an L-shaped guide hole (22), the operating handle (18) penetrates through the limiting clamping sleeve (17), and the part of the operating handle (18) located in the limiting clamping sleeve (17) is provided with a guide piece (23) in a radial direction, the guide piece (23) is arranged on the side of the connecting plate (16) away from the outer pressure ring (11), and the guide piece (23) penetrates through the L-shaped guide hole (22). Figure 2 ​As shown, the connecting plate 16 includes a connecting portion 24, a swing portion 25 and a movable portion 26, the connecting portion 24 is mounted on the inner pressure ring 12, the swing portion 25 is inclinedly arranged towards the direction away from the outer pressure ring 11, and the through hole 19 is arranged on the movable portion 26.

[0039] As shown in the accompanying drawings, the limiting sleeve 17 is sleeved with a gasket 27 on the outer periphery, and the gasket 27 is arranged between the guide member 23 and the movable portion 26. Figure 2

[0040] As shown in the accompanying drawings, the outer pressure ring 11 is provided with a screw rod 28, one end of the limiting sleeve 17 is threadedly matched with the screw rod 28, that is, the end of the limiting sleeve 17 has an inner thread matched with the screw rod 28, and the guide member 23 is a screw, which is threadedly connected to the side of the operating handle 18, that is, the side of the handle has a screw hole matched with the screw. Figure 2

[0041] As shown in the accompanying drawings, the rotary overturning lifting machine 9 includes a first driving motor 29, the output end of the first driving motor 29 is connected with a rotary base 30 through gear transmission, the rotary base 30 is provided with a lifting fixed frame 31, the top of the lifting fixed frame 31 is provided with a second driving motor 32, the motor shaft of the second driving motor 32 is connected with a first lead screw 33 in linkage, the first lead screw 33 is connected with a lifting seat 34 in matching, the two sides of the lifting seat 34 are respectively rotatably connected with a pulley 35, the two inner sides of the lifting fixed frame 31 are respectively provided with a limiting guide rail 36 matched with the pulley 35, the lifting seat 34 is further connected with a first connecting block 37 in linkage, the two sides of the first connecting block 37 are provided with a first guide groove 38 extending in the vertical direction in staggered arrangement, the lifting fixed frame 31 is provided with a first guide plate 39 matched with the first guide groove 38, the first connecting block 37 is provided with a third driving motor 40, the output end of the third driving motor 40 is connected with an overturning frame 41 in linkage, and the two ends of the overturning frame 41 are respectively provided with a first telescopic rod 42; the two sides of the material tank 3 are respectively provided with a positioning block 43, and the positioning block 43 is provided with a positioning sleeve 44 for inserting the corresponding first telescopic rod 42. Figures 3-6

[0042] As shown in the accompanying drawings, the outer pressure ring 11 is provided with a screw rod 28, one end of the limiting sleeve 17 is threadedly matched with the screw rod 28, that is, the end of the limiting sleeve 17 has an inner thread matched with the screw rod 28, and the guide member 23 is a screw, which is threadedly connected to the side of the operating handle 18, that is, the side of the handle has a screw hole matched with the screw. Figure 7 Figure 8 ​​​​As shown, the fixed lifting machine 6 comprises a lifting mounting frame 45, the bottom of the lifting mounting frame 45 is provided with a fourth driving motor 46, the motor shaft of the fourth driving motor 46 is connected with a second lead screw 47 in linkage, the second lead screw 47 is connected with a lifting frame 48 in cooperation, the lifting frame 48 is provided with two vertically extending guide holes 49, the lifting frame 48 is provided with two guide rods 50 matched with the guide holes 49, the lifting frame 48 is further connected with a second connecting block 51 in linkage, the second connecting block 51 is provided with two vertically extending second guide grooves 52 arranged in staggered manner on the two sides, the lifting mounting frame 45 is provided with a second guide plate 53 matched with the second guide grooves 52, the second connecting block 51 is provided with a support arm 54, the support arm 54 is provided with a second telescopic rod 55 at each end for inserting into the corresponding positioning sleeve 44.

[0043] As shown in the accompanying drawings, Figure 1 As shown, the transport mechanism 8 comprises a transport track 56 and a transport trolley 57 slidingly arranged on the transport track 56, the transport trolley 57 is provided with a first support frame 58 on each side, the first support frame 58 is provided with a first positioning recess 59 for embedding the corresponding positioning block 43 in the middle, the transfer trolley 7 is provided with a second support frame 60 on each side, the second support frame 60 is provided with a second positioning recess 61 for embedding the corresponding positioning block 43 in the middle.

[0044] The application also provides a method for the automatic transfer and discharge of the RTP sterile valve tank, comprising the following steps:

[0045] a. Sterilize the good material tank in the horizontal cleaning machine;

[0046] b. Move the material tank to the rotary turnover lifting machine through the transfer trolley, and abut the first telescopic rod on the rotary turnover lifting machine with the positioning sleeve on the material tank in place;

[0047] c. Transport the material tank on the rotary turnover lifting machine to the fixed lifting machine through the transport trolley, and abut the second telescopic rod on the fixed lifting machine with the positioning sleeve on the material tank in place;

[0048] d. Start the fixed lifting machine to lift the material tank to a set height, adjust the limiting handle assembly on the sterile adjustable abutting mechanism to ensure that the auxiliary valve on the material tank is abutted with the main valve port on the sterile isolator at this time; when the main valve port on the sterile isolator is abutted with the auxiliary valve from bottom to top, the guide piece is clamped below the L-shaped guide hole of the limiting sleeve, so that the inner and outer circles of the silica gel sleeve are closer, and the silica gel sleeve is arched; after the auxiliary valve enters the clamping groove of the main valve port, manually push the operating handle a little upwards and make the guide piece rotate to the axial guide hole of the L-shaped guide hole again, release the handle, and use the weight of the main valve to make the main valve port completely cover the auxiliary valve;

[0049] e、Manual operation of the main valve through gloves in a sterile isolator, open the main valve, then place the hopper into the main valve, open the horizontal cleaning machine discharge, visually check the stopper to the appropriate position, stop the discharge;

[0050] f、After the discharge is completed, remove the hopper, close the main valve, start the fixed elevator, and place the tank on the transport trolley to the original position.

[0051] The entire process of transferring and discharging with the PTP valve on the filling line completely realizes the closed and positive pressure transfer of the stopper, avoids cross contamination, and ensures the higher aseptic requirements of the new version of GMP for special stoppers.

Claims

1. An RTP aseptic valve tank discharge temporary storage automatic transfer discharging device, comprising a horizontal cleaning machine (1), an aseptic isolator (2) arranged on the side of the horizontal cleaning machine (1), and a tank (3), wherein a main valve port (4) of the aseptic isolator (2) is arranged in an inclined downward manner, and a secondary valve (5) is arranged on the tank (3), characterized in that: The fixed lifting machine (6), the transfer trolley (7), the transport mechanism (8) and the rotary overturning lifting machine (9) are further included, the transfer trolley (7) is used for transporting the material tank (3) to the rotary overturning lifting machine (9) or away from the material tank (3), the fixed lifting machine (6) is arranged below the sterile isolator (2), the transport mechanism (8) is arranged between the rotary overturning lifting machine (9) and the fixed lifting machine (6) and is used for transporting the material tank (3) arranged on the rotary overturning lifting machine (9) to the fixed lifting machine (6), the main valve port (4) of the sterile isolator (2) is provided with a sterile adjustable docking mechanism (10) for docking the auxiliary valve (5) on the material tank (3) with the main valve port (4) on the sterile isolator (2); the sterile adjustable docking mechanism (10) comprises an outer pressure ring (11), an inner pressure ring (12), a silica gel sleeve (13), a docking clamp (14) and a limiting handle assembly (15), the outer edge and the inner edge of the silica gel sleeve (13) are connected to the outer pressure ring (11) and the inner pressure ring (12) respectively, the docking clamp (14) is rotationally connected to the inner pressure ring (12), and the limiting handle assembly (15) is connected between the inner pressure ring (12) and the outer pressure ring (11) and is used for changing the axial position of the inner pressure ring (12) relative to the outer pressure ring (11).

2. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 1, characterized in that: The limiting handle assembly (15) comprises a connecting plate (16), a limiting sleeve (17) and an operating handle (18), one end of the connecting plate (16) is connected to the inner pressure ring (12), the other end of the connecting plate (16) is provided with a through hole (19), one end of the limiting sleeve (17) is connected to the outer pressure ring (11), and the limiting sleeve (17) penetrates the through hole (19), the side of the limiting sleeve (17) is provided with an axially extending axial guide hole (20), one end of the axial guide hole (20) close to the outer pressure ring (11) is provided with a circumferentially extending circumferential guide hole (21), the axial guide hole (20) and the circumferential guide hole (21) are connected into an L-shaped guide hole (22), the operating handle (18) penetrates the limiting sleeve (17), and the part of the operating handle (18) in the limiting sleeve (17) is provided with a guide piece (23) in the radial direction, the guide piece (23) is arranged on the side of the connecting plate (16) away from the outer pressure ring (11), and the guide piece (23) penetrates the L-shaped guide hole (22).

3. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 2, characterized in that: The connecting plate (16) comprises a connecting portion (24), a swing portion (25) and a movable portion (26), the connecting portion (24) is mounted on the inner pressure ring (12), the swing portion (25) is arranged in an inclined manner away from the outer pressure ring (11), and the through hole (19) is arranged on the movable portion (26).

4. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 3, characterized in that: The outer periphery of the limiting sleeve (17) is further provided with a gasket (27), and the gasket (27) is arranged between the guide piece (23) and the movable portion (26).

5. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 2, characterized in that: The outer pressure ring (11) is provided with a screw rod (28), one end of the limiting sleeve (17) is in threaded connection with the screw rod (28), and the guide piece (23) is a screw and is in threaded connection with the side of the operating handle (18).

6. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 1, characterized in that: The rotary overturning lifting machine (9) comprises a first driving motor (29), the output end of the first driving motor (29) is connected with a rotary base (30) through gear transmission, the rotary base (30) is provided with a lifting fixing frame (31), the top of the lifting fixing frame (31) is provided with a second driving motor (32), the motor shaft of the second driving motor (32) is connected with a first lead screw (33) in linkage, the first lead screw (33) is connected with a lifting seat (34) in matching, the two sides of the lifting seat (34) are rotatably connected with pulleys (35), the two inner sides of the lifting fixing frame (31) are respectively provided with a limiting guide rail (36) matched with the pulleys (35), the lifting seat (34) is further connected with a first connecting block (37) in linkage, the two sides of the first connecting block (37) are provided with first guide grooves (38) extending in the vertical direction in a staggered mode, the lifting fixing frame (31) is provided with first guide plates (39) matched with the first guide grooves (38), the first connecting block (37) is provided with a third driving motor (40), the output end of the third driving motor (40) is connected with an overturning frame (41) in linkage, and the two ends of the overturning frame (41) are respectively provided with a first telescopic rod (42); the two sides of the material tank (3) are respectively provided with a positioning block (43), and the positioning block (43) is provided with a positioning sleeve (44) for inserting the corresponding first telescopic rod (42).

7. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 6, characterized in that: The fixed lifting machine (6) comprises a lifting mounting frame (45), the bottom of the lifting mounting frame (45) is provided with a fourth driving motor (46), the motor shaft of the fourth driving motor (46) is connected with a second lead screw (47) in linkage, the second lead screw (47) is connected with a lifting frame (48) in matching, the lifting frame (48) is provided with two guide holes (49) extending in the vertical direction, the lifting frame (48) is provided with two guide rods (50) matched with the guide holes (49), the lifting frame (48) is further connected with a second connecting block (51) in linkage, the two sides of the second connecting block (51) are provided with second guide grooves (52) extending in the vertical direction in a staggered mode, the lifting mounting frame (45) is provided with second guide plates (53) matched with the second guide grooves (52), the second connecting block (51) is provided with a support arm (54), and the two ends of the support arm (54) are respectively provided with a second telescopic rod (55) inserted into the corresponding positioning sleeve (44).

8. The RTP aseptic valve tank outfeed temporary storage automatic transfer and outfeed device according to claim 6, characterized in that: The conveying mechanism (8) comprises a conveying track (56) and a conveying trolley (57) slidingly arranged on the conveying track (56), and one first support frame (58) is arranged on each side of the conveying trolley (57), and a first positioning recess (59) for embedding a corresponding positioning block (43) is arranged in the middle of the first support frame (58); one second support frame (60) is arranged on each side of the transfer trolley (7), and a second positioning recess (61) for embedding a corresponding positioning block (43) is arranged in the middle of the second support frame (60).

9. The method of claim 1-8, wherein the method is characterized in that: The method comprises the following steps: a. Sterilize the material tank in the horizontal cleaning machine; b. Move the material tank to the rotary overturning elevator through the transfer trolley, and butt joint the first telescopic rod on the rotary overturning elevator and the positioning sleeve on the material tank in place; c. Carry the material tank on the rotary overturning elevator to the fixed elevator through the conveying trolley, and butt joint the second telescopic rod on the fixed elevator and the positioning sleeve on the material tank in place; d. Start the fixed elevator to lift the material tank to the set height, adjust the limiting handle assembly on the sterile adjustable butt joint mechanism to ensure that the auxiliary valve on the material tank is butt jointed with the main valve port on the sterile isolator at this time; when the main valve port on the sterile isolator is butt jointed with the auxiliary valve from bottom to top, the guide piece is clamped below the L-shaped guide hole of the limiting sleeve, so that the inner and outer rings of the silica gel sleeve are closer, and the silica gel sleeve is arched a lot; when the auxiliary valve enters the clamping groove of the main valve port, manually push the operating handle a little bit upward and make the guide piece rotate to the axial guide hole of the L-shaped guide hole again, loosen the handle, and use the weight of the main valve to make the main valve port completely cover the auxiliary valve; e. Manually operate the main valve in the sterile isolator through the glove, open the main valve, then put the discharge hopper into the main valve port, open the horizontal cleaning machine for discharging, visually check that the rubber plug reaches the appropriate position, and stop discharging; f. After discharging is completed, take out the hopper, close the main valve, start the fixed elevator, and put the material tank on the conveying trolley to transport it to the original position.

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