A pharmaceutical device, a pharmaceutical method and a medicament of regadenoson injection

Abstract

The application discloses a pharmaceutical equipment and method for regadenoson injection and the medicine thereof, and particularly relates to the technical field of the pharmaceutical equipment for regadenoson injection, and comprises the manufacturing pharmaceutical equipment and the injection. The knocking device is arranged, and the impurities adhered to the inner wall of the feeding hopper are not easy to be accumulated to cause the blockage of the discharge port of the feeding hopper and affect the later filtering through the continuous knocking of the knocking rod. In addition, the injection is a colorless and transparent liquid, the pH value is 3.9-5.0, and the content of regadenoson is 93.0%-103.0% of the marked amount.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical equipment technology for Reganoxon injection, and in particular to a pharmaceutical equipment, pharmaceutical method and pharmaceutical preparation for Reganoxon injection. Background Technology

[0002] Reganoxon injection is a small-volume injectable preparation made from reganoxon as the main active pharmaceutical ingredient and excipients such as disodium hydrogen phosphate and propylene glycol. The specification is 0.4 mg / 5 mL, and it is indicated for diagnostic purposes. Reganoxon is a selective coronary vasodilator used for adult drug stress testing: radionuclide myocardial perfusion imaging (MPI) in patients who cannot tolerate sufficient exercise load; and for measuring the FFR of a single coronary artery stenosis during invasive coronary angiography when repeated measurements of fractional flow reserve (FFR) are not expected. Dosage and administration: 1. USA: The recommended dose is (5 mL: 0.4 mg), administered intravenously over 10 seconds. 2. Europe: The recommended dose is a single intravenous injection (5 mL: 0.4 mg), without adjustment based on body weight. Radionuclide myocardial perfusion imaging (MPI): One intravenous injection within 24 hours. Measurement of FFR of a single coronary artery stenosis: No more than two intravenous injections within 24 hours, with an interval of at least 10 minutes between each injection.

[0003] The main research focuses on the formulation analysis, quality standard research, production process research, and stability studies of Reganoxon injection. Through one batch of pilot-scale testing and three batches of large-scale validation production trials, the company aims to establish new standards and production process specifications to pass the review of the National Medical Products Administration and ultimately obtain a production license and achieve industrialization. The company possesses a provincial-level engineering technology research center, demonstrating significant research capabilities. It also has a small-volume injection workshop that meets the requirements of the new GMP standards, building fire protection codes, and cleanroom design specifications. Equipped with advanced domestic water treatment equipment, the workshop ensures that water quality indicators such as TOC and conductivity exceed existing standards. The production utilizes a washing, filling, and sealing integrated line, autoclaving, and an online CIP-SIP system for cleaning, disinfection, and sterilization. Supporting public facilities are also provided to prevent contamination and cross-contamination during material transfer, production inspection, and storage.

[0004] Pharmaceutical equipment for Reganoxane injection is an important type of machinery in the biopharmaceutical process. It is usually a device that processes each step in the pharmaceutical process, including reaction vessels and filtration and purification machines.

[0005] The inventors discovered that when using pharmaceutical equipment to filter Reganoxon injection during production, the prepared Reganoxon injection is typically added to the feed hopper of a filtration and purification machine. After passing through a first filter screen on the first frame and a second filter screen on the second frame for double filtration, the resulting clear liquid is stored in a storage tank. Impurities in the liquid are filtered through the first and second filter screens, achieving a filtration and purification effect. However, after adding the original Reganoxon injection solution to the feed hopper, some impurities may adhere to the hopper's outlet. Over time, this can reduce the flow rate at the hopper outlet, increasing filtration time and reducing the filtration efficiency. Summary of the Invention

[0006] This invention addresses the problem that after adding the stock solution of Reganoxon injection to the feed hopper, some impurities may adhere to the outlet of the feed hopper, which over time can reduce the feed flow at the outlet, thereby increasing the filtration time and reducing the filtration effect. The invention provides a pharmaceutical equipment, pharmaceutical method, and pharmaceutical reagent for Reganoxon injection.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: a pharmaceutical equipment, pharmaceutical method, and pharmaceutical preparation for Reganoxon injection, comprising a drug storage tank and a second filter screen, wherein a control box is fixedly connected to one side of the drug storage tank, a drug outlet valve pipe is provided on one side of the drug storage tank, a support shell is fixedly connected to the top of the drug storage tank, a feed hopper is fixedly connected to the top of the support shell, a first frame is rotatably connected to the inner wall of the support shell, a servo motor is fixedly connected to one side of the first frame, one side of the servo motor is fixedly connected to one side of the support shell, the outer surface of the output end of the servo motor is penetrated and connected to one side of the support shell, a first filter screen is provided on the inner wall of the first frame, a second frame is slidably connected to the inner wall of the support shell, a striking device is provided on one side of the support shell, an intercepting device is provided on one side of the first frame, and a moving device is provided between the inner wall of the second frame and the outer surface of the second filter screen;

[0008] The striking device includes a mounting block. A mounting hole is formed on one side of the support shell, and the inner wall of the mounting hole is fixedly connected to the outer surface of the mounting block. A first rectangular hole is formed on one side of the mounting block, and a round shaft is rotatably connected to the inner wall of the first rectangular hole. A rotating rod is fixedly connected to the outer surface of the round shaft. Both sides of the rotating rod near the first frame are beveled. The size and shape of the outer surface of the rotating rod are adapted to the size and shape of the inner wall of the first rectangular hole. A striking rod is fixedly connected to one side of the rotating rod. A round hole is formed on one side of the support shell, and a sliding rod is slidably connected to the inner wall of the round hole. One side of the sliding rod is fixedly connected to one side of the first frame, and the outer surface of the sliding rod is fitted with... A first spring is provided, with its two ends fixedly connected to one side of the support shell and one side of the slide rod, respectively. The two ends of the striking rod are respectively close to the feed hopper and one side of the slide rod. A first rectangular groove is provided on both sides of the inner wall of the first rectangular hole. A telescopic rod is fixedly connected to the inner wall of the first rectangular groove. A sealing block is fixedly connected to one end of the telescopic rod. The four sides of the sealing block are slidably connected to the inner walls of the first rectangular groove and the first rectangular hole. A second spring is sleeved and connected to the outer surface of the telescopic rod. The two ends of the second spring are fixedly connected to the sealing block and the inner wall of the first rectangular groove, respectively. An elastic block is fixedly connected to one side of the sealing block. One side of the elastic block is fixedly connected to one side of the rotating rod.

[0009] The effect achieved by the above components is as follows: By setting up a striking device, when some impurities adhere to the wall of the feed hopper, the servo motor can be activated to drive the first frame and the first filter screen to swing up and down at a certain arc. When one end of the first frame moves downward, it presses against one side of the rotating rod, causing one end to move downward and tilt to a certain angle around the circular axis on the inner wall of the mounting block. The other end of the rotating rod will cause the striking rod to tilt, causing one end to strike the outer surface of the feed hopper, causing the feed hopper to vibrate and shake off the impurities attached inside. Then, when one end of the first frame moves upward, it will cause the rotating rod to tilt to the other end, thereby causing the other end of the striking rod to strike the sliding rod, causing its outer surface to slide inward in the circular hole, pushing the second frame to slide in the support shell. At the same time, the first spring will contract between one side of the sliding rod and one side of the support shell. When the first frame drives the striking rod to strike the feed hopper again, one end of the sliding rod will tilt up, and then the first spring will... Under the reset action, the sliding rod slides outward, which in turn causes the second frame to slide to one side within the support shell. This back-and-forth sliding causes the internally installed second filter screen to shake, accelerating the permeation and filtration of any unpermeated Reganoxon injection concentrate on its surface. As the rotating rod rotates back and forth around the circular axis, the two elastic blocks, pulled back and forth by the rotating rod, cause the sealing block to slide back and forth within the first rectangular hole and the first rectangular groove. Simultaneously, the telescopic rod and the second spring on one side stretch, contract, and reset. The sealing block and elastic block can seal and block both sides of the rotating rod, preventing the filtered concentrate from overflowing from the first rectangular hole. Furthermore, the continuous tapping by the tapping rod prevents impurities adhering to the inner wall of the feed hopper from accumulating and causing blockage at the feed hopper outlet, thus affecting subsequent filtration. At the same time, the tapping and vibration of the second frame and the second filter screen can accelerate the filtration efficiency of the Reganoxon injection concentrate adhering to the second filter screen.

[0010] Preferably, the longitudinal section of the elastic block is wrinkled, and the elastic block is made of silicone.

[0011] The effect achieved by the above components is as follows: by setting the elastic block to be pleated and made of silicone, since silicone is elastic, it is not easy to resist the rotation rod, which facilitates sealing without hindering the rotation of the rotation rod.

[0012] Preferably, a protective block is fixedly connected to one side of the slide bar, and the protective block is made of rubber.

[0013] The effect achieved by the above components is that by setting up protective blocks, the wear on one side of the slide bar caused by the striking rod can be reduced, thereby increasing the service life of the slide bar.

[0014] Preferably, the interception device includes a first interception plate, a slot is provided on one side of the first frame, the size and shape of the inner wall of the slot are adapted to the size and shape of the outer surface of the first interception plate, a plurality of first interception holes are provided on the outer surface of the first interception plate, and the slot is located above the first filter screen.

[0015] The effect achieved by the above-mentioned components is as follows: By setting up an interception device, before filtering the raw solution of Reganoxon injection, the first interception plate is first inserted into the slot on the first frame, so that it is positioned above the first filter screen. When the raw solution of Reganoxon injection is filtered, the impurities of the raw solution are first intercepted by the first interception plate. The raw solution of Reganoxon injection flows into the first filter screen through the first interception hole for further filtration. When a large amount of impurities are attached to the surface of the first interception plate and it needs to be replaced, the servo motor is started by the control box to drive the first frame to tilt to a certain angle and raise the side closest to the feed hopper to its highest point. Then, under the action of gravity, the first interception plate will slide out of the slot and fall out. Then, a new first interception plate is manually installed in the slot to continue filtration. This can reduce the replacement frequency of the first filter screen. At the same time, the easy-to-replace first interception plate can reduce the replacement time and improve the filtration efficiency.

[0016] Preferably, the interception device further includes a second interception plate, the size and shape of the outer surface of the second interception plate being adapted to the size and shape of the inner wall of the slot, a plurality of circular grooves being provided on one side of the second interception plate, a plurality of second interception holes being provided on the inner wall of the circular grooves, and a plurality of diversion grooves being provided around the circular grooves on one side of the second interception plate.

[0017] The effect achieved by the above components is as follows: by setting a second interceptor plate, which has several drainage grooves, the original solution of Reganoxon injection can be effectively guided into the circular groove. Then the clear solution will flow out from the second interceptor hole, and the impurities will accumulate in the circular groove and be filtered down, making them concentrated for easy cleaning and maintenance later.

[0018] Preferably, the bottom of the inner wall of the drainage channel is inclined, and several drainage channels are arranged at equal intervals.

[0019] The effect achieved by the above components is that by setting the bottom of the inner wall of the drainage channel to be inclined, the original solution of Reganosin injection can flow into the circular channel quickly, thereby increasing the drainage speed of the drainage channel.

[0020] Preferably, a handle block is fixedly connected to one side of both the first and second interceptor plates, and the cross-section of the handle block is U-shaped.

[0021] The effect achieved by the above-mentioned components is that, by setting the handle block, when the first and second interceptor plates are installed in the slot, the handle block can be easily held by the installer and picked up for installation.

[0022] Preferably, the moving device includes a toothed plate, second rectangular grooves symmetrically formed on the inner wall of the second frame, the inner wall of the second rectangular grooves being slidably connected to both sides of the second filter screen, one of the second rectangular grooves having a second rectangular hole in its inner wall, one side of the toothed plate being fixedly connected to one side of the second filter screen, both sides of the toothed plate being slidably connected to the inner wall of the second rectangular groove, a third rectangular hole in one side of the support shell, a first round rod fixedly connected to the side of the first frame away from the servo motor, the outer surface of the first round rod being threaded through and connected to one side of the support shell, a connecting rope fixedly connected to the outer surface of the first round rod, a U-shaped block fixedly connected to one side of the support shell, a second round rod threaded through and connected to one side of the inner wall of the U-shaped block, a gear fixedly connected to one end of the second round rod, the outer surface of the gear meshing with one side of the toothed plate, the inner wall sizes of the second and third rectangular holes being adapted to the outer surface size of the gear, a torsion spring sleeved on the outer surface of the second round rod, the two ends of the torsion spring being fixedly connected to one side of the U-shaped block and the top of the gear, respectively.

[0023] The effect achieved by the above components is as follows: By setting up a moving device, when it is necessary to replace the first and second intercepting plates in the intercepting device, the servo motor will be activated by the control box to drive the first frame to tilt to a certain angle and raise the side closest to the feed hopper to its highest point. At this time, when the first frame rotates, it will drive the first round rod to rotate on the support shell, and then drive the connecting rope to wind up one end of the first round rod. The other end of the connecting rope will drive the second round rod to rotate to a certain position in the inner wall of the U-shaped block. The torsion spring will deform between the second round rod and the U-shaped block, so that one end will drive the gear to rotate in the second and third rectangular holes, causing it to drive the toothed plate and the second filter screen to rotate. The second rectangular groove slides to the position away from the inner wall of the support shell, allowing the original solution of Reganosheng injection that flows into the first filter screen away from the feed hopper to pass through the second filter screen for secondary filtration. When it is replaced and turned back, the connecting rope will loosen and be released. Under the reset action of the torsion spring, it will drive the second round rod to rotate and rewind the connecting rope, and drive the gear to rotate and slide the toothed plate and the second filter screen back to the original position. Through the moving device, the second filter screen can be moved back and forth in the second frame according to the inclination of the first frame to a certain position, so that it can always receive the original solution of Reganosheng injection filtered by the first filter screen for secondary filtration.

[0024] Preferably, a bearing is fixedly connected to the top of the second round rod, and the outer ring of the bearing is fixedly connected to one side of the inner wall of the U-shaped block.

[0025] The effect achieved by the above components is that by setting bearings, the top of the second round rod can be limited to one side of the inner wall of the U-shaped block, making it less prone to shaking and more stable when rotating.

[0026] Preferably, a pharmaceutical apparatus, a pharmaceutical method, and a pharmaceutical agent for a Reganoxon injection as described above are also provided, comprising the following steps:

[0027] S1. When preparing Reganosine Injection, the required raw materials are prepared first and then put into a mixing container in a certain proportion and stirred evenly.

[0028] S2. Before filtering the original solution of Reganoxon injection, manually hold the handle block to lock the first interceptor plate into the slot on the first frame, so that it is above the first filter screen. When filtering, the original solution of Reganoxon injection will first pass through the first interceptor plate to intercept its impurities, and the original solution of Reganoxon injection will flow into the first filter screen through the first interception hole for further filtration.

[0029] S3. Then, pour the prepared Reganoxon injection stock solution into the feed hopper, and let it fall from the outlet of the feed hopper onto the top of the first filter screen for the first filtration. This can initially filter out large particulate impurities in the Reganoxon injection stock solution. Then, it falls through the filter holes of the first filter screen onto the second filter screen on the second frame for the second filtration. The Reganoxon injection stock solution that has passed through the second filtration will be stored in the drug storage tank at the bottom, and then discharged through the drug outlet valve.

[0030] S4. When some impurities adhere to the wall of the feed hopper, the servo motor can be activated to drive the first frame and the first filter screen to swing up and down at a certain arc. When one end of the first frame moves downward, it presses against one side of the rotating rod, causing one end to move downward and tilt to a certain angle around the circular axis on the inner wall of the mounting block. The other end of the rotating rod will cause the striking rod to tilt, causing one end to strike the outer surface of the feed hopper, causing the feed hopper to vibrate and shake off the impurities attached inside. Then, when one end of the first frame moves upward, it will cause the rotating rod to tilt to the other end, thereby causing the other end of the striking rod to strike the protective block on one end of the slide rod, causing its outer surface to slide inward in the circular hole, pushing the second frame to slide in the support shell. At the same time, the first spring will contract between one side of the slide rod and one side of the support shell. When the first frame drives the striking rod to strike the feed hopper again, one end of the slide rod will tilt up, and then under the reset action of the first spring... The sliding rod moves outward, causing the second frame to slide to one side within the support housing. This back-and-forth sliding causes the internal second filter screen to vibrate, accelerating the filtration of any unfiltered Reganoxon injection concentrate. As the rotating rod rotates back and forth around the circular axis, the two elastic blocks, pulled back and forth by the rotating rod, cause the sealing block to slide back and forth within the first rectangular hole and the first rectangular groove. Simultaneously, the telescopic rod and the second spring on one side stretch, contract, and reset. The sealing block and elastic blocks seal and block both sides of the rotating rod, preventing the filtered concentrate from overflowing from the first rectangular hole. Furthermore, the continuous tapping by the tapping rod prevents impurities adhering to the inner wall of the feed hopper from accumulating and causing blockage at the feed hopper outlet, thus affecting subsequent filtration. At the same time, the tapping and vibration of the second frame and the second filter screen accelerates the filtration efficiency of the Reganoxon injection concentrate adhering to the second filter screen.

[0031] S5. When a large amount of impurities are attached to the surface of the first interceptor plate and it needs to be replaced, the servo motor is started by the control box to drive the first frame to tilt to a certain angle and raise the side closest to the feed hopper to the highest point. Then, under the action of gravity, the first interceptor plate will slide out of the slot and fall out. Then, the new first interceptor plate is manually installed in the slot to continue filtering. This can reduce the replacement frequency of the first filter screen. At the same time, the easy-to-replace first interceptor plate can reduce the replacement time and improve the filtration efficiency.

[0032] S6. When it is necessary to replace the first and second interceptor plates, the servo motor will be activated via the control box to tilt the first frame to a certain angle, raising it to its highest position on the side closest to the feed hopper. At this time, the rotation of the first frame will cause the first round rod to rotate on the support shell, thereby causing the connecting rope to wind up at one end of the first round rod. The other end of the connecting rope will cause the second round rod and bearing to rotate to a certain position within the inner wall of the U-shaped block. The torsion spring will deform between the second round rod and the U-shaped block, causing one end to drive the gear to rotate in the second and third rectangular holes, thus driving the toothed plate and the second filter screen to move away from the support in the second rectangular groove. One end of the inner wall of the frame slides to the corresponding position, allowing the original liquid of Reganosheng injection that flows into the first filter screen away from the feed hopper to pass through the second filter screen for secondary filtration. When it is replaced and turned back, the connecting rope will loosen and be released. Under the reset action of the torsion spring, it will drive the second round rod to rotate and rewind the connecting rope, and drive the gear to rotate and slide the toothed plate and the second filter screen back to the original position. Through the moving device, the second filter screen can be moved back and forth in the second frame to a certain position according to the inclination of the first frame, so that it can always receive the original liquid of Reganosheng injection filtered by the first filter screen for secondary filtration.

[0033] S7. Finally, fill the filtered medicine into the cleaned ampoules, seal them, sterilize and package them after leak detection.

[0034] Preferably, a pharmaceutical preparation manufactured by the pharmaceutical equipment for the above-described Reganoxon injection is also provided, which is an injection, a colorless and clear liquid with a pH value of 3.9-5.0, and contains Reganoxon at 93.0%-103.0% of the labeled amount.

[0035] In summary, the beneficial effects of the present invention are as follows:

[0036] By setting up a striking device and continuously striking with a striking rod, impurities adhering to the inner wall of the feed hopper are less likely to accumulate and cause blockage at the feed hopper outlet, thus affecting subsequent filtration. At the same time, striking and vibrating the second frame and the second filter screen can accelerate the filtration efficiency of the original solution of Reganosine injection adhering to the second filter screen.

[0037] By setting up an interception device, the frequency of replacing the first filter screen can be reduced. At the same time, the easy-to-replace first and second interception plates can reduce replacement time and improve filtration efficiency.

[0038] By setting up a moving device, the second filter screen can be moved back and forth in the second frame to a certain position according to the tilt of the first frame, so that it can always receive the original solution of Reganosin injection filtered by the first filter screen for secondary filtration. Attached Figure Description

[0039] Figure 1 This is a three-dimensional schematic diagram of the medicine storage tank of the present invention.

[0040] Figure 2 This is a three-dimensional schematic diagram of the support shell of the present invention.

[0041] Figure 3 This is a three-dimensional schematic diagram of the mounting block of the present invention.

[0042] Figure 4 This is a three-dimensional schematic diagram of the rotating rod of the present invention.

[0043] Figure 5 This is a three-dimensional schematic diagram of the slide bar of the present invention.

[0044] Figure 6 This is a three-dimensional schematic diagram of the elastic block of the present invention.

[0045] Figure 7 This is a three-dimensional schematic diagram of the control box of the present invention.

[0046] Figure 8 This is a three-dimensional schematic diagram of the first frame of the present invention.

[0047] Figure 9 This is a three-dimensional schematic diagram of the first interceptor plate of the present invention.

[0048] Figure 10 This is a three-dimensional schematic diagram of the second frame of the present invention.

[0049] Figure 11 This is a three-dimensional schematic diagram of the second interceptor plate of the present invention.

[0050] Figure 12 This is a three-dimensional schematic diagram of the toothed plate of the present invention.

[0051] Figure 13 This is a three-dimensional schematic diagram of the gear of the present invention.

[0052] Explanation of reference numerals in the attached figures:

[0053] 1. Medicine storage tank; 2. Striking device; 3. Interception device; 4. Moving device; 5. Control box; 6. Medicine outlet valve pipe; 7. Support shell; 8. Feed hopper; 9. First frame; 10. Servo motor; 11. First filter screen; 12. Second frame; 13. Second filter screen; 21. Mounting hole; 22. Mounting block; 23. First rectangular hole; 24. Round shaft; 25. Rotating rod; 26. Striking rod; 27. Round hole; 28. Sliding rod; 29. ​​First spring; 210. First rectangular groove; 211. Telescopic rod; 21 2. Sealing block; 213. Second spring; 214. Elastic block; 215. Protective block; 31. Slot; 32. First intercepting plate; 33. First intercepting hole; 34. Second intercepting plate; 35. Circular groove; 36. Drainage groove; 37. Second intercepting hole; 38. Handle block; 41. Second rectangular groove; 42. Second rectangular hole; 43. Toothed plate; 44. Third rectangular hole; 45. First round rod; 46. Connecting rope; 47. U-shaped block; 48. Second round rod; 49. Gear; 410. Torsion spring; 411. Bearing. Implementation

[0054] Reference Figure 1-13 As shown, this embodiment discloses a pharmaceutical equipment, pharmaceutical method and pharmaceutical preparation for Reganoxon injection, including a drug storage tank 1 and a second filter screen 13. A control box 5 is fixedly connected to one side of the drug storage tank 1, and a drug outlet valve pipe 6 is provided on one side of the drug storage tank 1. A support shell 7 is fixedly connected to the top of the drug storage tank 1, and a feed hopper 8 is fixedly connected to the top of the support shell 7. A first frame 9 is rotatably connected to the inner wall of the support shell 7. A servo motor 10 is fixedly connected to one side of the first frame 9. One side of the servo motor 10 is fixedly connected to one side of the support shell 7. The outer surface of the output end of the servo motor 10 is connected through to one side of the support shell 7. A first filter screen 11 is provided on the inner wall of the first frame 9. A second frame 12 is slidably connected to the inner wall of the support shell 7. A striking device 2 is provided on one side of the support shell 7. An intercepting device 3 is provided on one side of the first frame 9. A moving device 4 is provided between the inner wall of the second frame 12 and the outer surface of the second filter screen 13.

[0055] The striking device 2 includes a mounting block 22. A mounting hole 21 is provided on one side of the bracket housing 7. The inner wall of the mounting hole 21 is fixedly connected to the outer surface of the mounting block 22. A first rectangular hole 23 is provided on one side of the mounting block 22. A round shaft 24 is rotatably connected to the inner wall of the first rectangular hole 23. A rotating rod 25 is fixedly connected to the outer surface of the round shaft 24. The rotating rod 25 has beveled surfaces on both sides near the end of the first frame 9. The size and shape of the outer surface of the rotating rod 25 are adapted to the size and shape of the inner wall of the first rectangular hole 23. A striking rod 26 is fixedly connected to one side of the rotating rod 25. A round hole 27 is provided on one side of the bracket housing 7. A sliding rod 28 is slidably connected to the inner wall of the round hole 27. One side of the sliding rod 28 is fixedly connected to one side of the first frame 9. A first spring 29 is sleeved on the outer surface of the sliding rod 28. The two ends of the spring 29 are fixedly connected to one side of the bracket housing 7 and one side of the slide rod 28, respectively. The two ends of the striking rod 26 are close to the feed hopper 8 and the slide rod 28, respectively. The inner walls of the first rectangular hole 23 are provided with first rectangular grooves 210 on both sides. The inner walls of the first rectangular grooves 210 are fixedly connected with telescopic rods 211. One end of the telescopic rod 211 is fixedly connected with a sealing block 212. The four sides of the sealing block 212 are slidably connected to the inner walls of the first rectangular grooves 210 and the first rectangular hole 23. The outer surface of the telescopic rod 211 is sleeved with a second spring 213. The two ends of the second spring 213 are fixedly connected to the sealing block 212 and the inner walls of the first rectangular groove 210, respectively. One side of the sealing block 212 is fixedly connected with an elastic block 214. One side of the elastic block 214 is fixedly connected to one side of the rotating rod 25.The effect achieved by the above components is as follows: By setting the striking device 2, when some impurities adhere to the wall of the feed hopper 8, the servo motor 10 can be activated to drive the first frame 9 and the first filter screen 11 to swing up and down by a certain arc. When one end of the first frame 9 moves downward, it presses against one side of the rotating rod 25, causing one end to move downward and tilt to a certain angle around the circular shaft 24 on the inner wall of the mounting block 22. The other end of the rotating rod 25 will drive the striking rod 26 to tilt, causing one end to strike the outer surface of the feed hopper 8, causing the feed hopper 8 to move. The vibration causes impurities attached to the inside to fall off. Then, when one end of the first frame 9 moves upward, it drives the rotating rod 25 to tilt to the other end, thereby causing the other end of the striking rod 26 to strike the sliding rod 28. This causes the outer surface of the sliding rod 26 to slide inward in the circular hole 27, pushing the second frame 12 to slide in the support shell 7. At the same time, the first spring 29 will contract between one side of the sliding rod 28 and one side of the support shell 7. When the first frame 9 drives the striking rod 26 to strike the feed hopper 8 again, one end of the sliding rod 28 will lift up, and then the first spring 29 will return to its original position. When the rotating rod 25 is used, it causes the sliding rod 28 to slide outward, thereby causing the second frame 12 to slide to one side within the support shell 7. This back-and-forth sliding causes the internally installed second filter screen 13 to shake, accelerating the permeation and filtration of any unfiltered Reganoxon injection solution. When the rotating rod 25 rotates back and forth around the circular shaft 24, the two elastic blocks 214, pulled back and forth by the rotating rod 25, cause the sealing block 212 to slide back and forth within the first rectangular hole 23 and the first rectangular groove 210, while simultaneously causing the telescopic rod 211 on one side to... The second spring 213 will stretch, contract and reset. The sealing block 212 and the elastic block 214 can seal and block both sides of the rotating rod 25, making it difficult for the filtered raw liquid to overflow from the first rectangular hole 23. Then, by continuously striking the rod 26, the impurities attached to the inner wall of the feed hopper 8 will not accumulate and cause blockage at the outlet of the feed hopper 8, affecting the subsequent filtration. At the same time, the second frame 12 and the second filter screen 13 will be struck and vibrated, which can accelerate the filtration efficiency of the raw liquid of Reganosin injection attached to the second filter screen 13.

[0056] Reference Figure 2-6 As shown, this embodiment discloses that the longitudinal section of the elastic block 214 is wrinkled, and the elastic block 214 is made of silicone. By setting the elastic block 214 to be wrinkled and made of silicone, since silicone is elastic, it is not easy to cause resistance to the rotating rod 25, which facilitates sealing without hindering the rotation of the rotating rod 25.

[0057] Reference Figure 2-6 As shown in the figure, this embodiment discloses a protective block 215 fixedly connected to one side of the slide bar 28. The protective block 215 is made of rubber. By setting the protective block 215, the wear on one side of the slide bar 28 caused by the striking rod 26 can be reduced, thereby improving the service life of the slide bar 28. Example

[0058] Reference Figure 7-9 As shown, this embodiment discloses an interception device 3 including a first interception plate 32, a slot 31 is provided on one side of the first frame 9, the size and shape of the inner wall of the slot 31 are adapted to the size and shape of the outer surface of the first interception plate 32, a plurality of first interception holes 33 are provided on the outer surface of the first interception plate 32, and the slot 31 is located above the first filter screen 11. By setting up the interception device 3, before filtering the raw solution of Reganoxon injection, the first interception plate 32 is first inserted into the slot 31 on the first frame 9, so that it is positioned above the first filter screen 11. When filtering, the raw solution of Reganoxon injection will first pass through the first interception plate 32 to intercept its impurities. The raw solution of Reganoxon injection will then flow into the first filter screen 11 through the first interception hole 33 for further filtration. When a large amount of impurities are attached to the surface of the first interception plate 32 and it needs to be replaced, the servo motor 10 is started by the control box 5 to drive the first frame 9 to tilt to a certain angle and raise the side closest to the feed hopper 8 to its highest point. Then, under the action of gravity, the first interception plate 32 will slide out of the slot 31 and fall out. Then, a new first interception plate 32 is manually installed in the slot 31 to continue filtration. This can reduce the replacement frequency of the first filter screen 11. At the same time, the easy-to-replace first interception plate 32 can reduce replacement time and improve filtration efficiency. Example

[0059] Reference Figure 10 and Figure 11 As shown in the figure, this embodiment discloses that the interception device 3 also includes a second interception plate 34. The size and shape of the outer surface of the second interception plate 34 are adapted to the size and shape of the inner wall of the slot 31. A plurality of circular grooves 35 are formed on one side of the second interception plate 34, and a plurality of second interception holes 37 are formed on the inner wall of the circular grooves 35. A plurality of drainage grooves 36 are formed around one side of the second interception plate 34 around the circular grooves 35. By setting the second interception plate 34, which has a plurality of drainage grooves 36, the original solution of Reganoxon injection can be effectively guided into the circular grooves 35. Then the clear solution will flow out from the second interception holes 37, and the impurities will accumulate in the circular grooves 35 and be filtered down, making them concentrated for easy cleaning and maintenance later. The bottom of the inner wall of the drainage groove 36 is inclined, and the plurality of drainage grooves 36 are arranged at equal intervals. By setting the bottom of the inner wall of the drainage channel 36 to be inclined, the original solution of Reganoxon injection can flow quickly into the circular groove 35, increasing the drainage speed of the drainage channel 36. A handle block 38 is fixedly connected to one side of both the first interceptor plate 32 and the second interceptor plate 34. The handle block 38 has a U-shaped cross-section. By providing the handle block 38, when the first interceptor plate 32 and the second interceptor plate 34 are installed in the slot 31, the handle block 38 can be easily gripped and lifted by the installer for installation.

[0060] Reference Figure 12 and Figure 13As shown, this embodiment discloses a mobile device 4 including a toothed plate 43. The inner wall of the second frame 12 is symmetrically provided with second rectangular grooves 41. The inner wall of the second rectangular grooves 41 is slidably connected to both sides of the second filter screen 13. One of the second rectangular grooves 41 has a second rectangular hole 42 on its inner wall. One side of the toothed plate 43 is fixedly connected to one side of the second filter screen 13, and both sides of the toothed plate 43 are slidably connected to the inner wall of the second rectangular grooves 41. A third rectangular hole 44 is provided on one side of the support shell 7. A first round rod 45 is fixedly connected to the side of the first frame 9 away from the servo motor 10. The outer surface of the first round rod 45 is connected to the support shell 7. A connecting rope 46 is fixedly connected to the outer surface of the first round rod 45 through one side of the frame shell 7. A U-shaped block 47 is fixedly connected to one side of the frame shell 7. A second round rod 48 is connected through one side of the inner wall of the U-shaped block 47. A gear 49 is fixedly connected to one end of the second round rod 48. The outer surface of the gear 49 meshes with one side of the toothed plate 43. The inner wall sizes of the second rectangular hole 42 and the third rectangular hole 44 are adapted to the outer surface size of the gear 49. A torsion spring 410 is sleeved and connected to the outer surface of the second round rod 48. The two ends of the torsion spring 410 are fixedly connected to one side of the U-shaped block 47 and the top of the gear 49, respectively. When the first interceptor plate 32 and the second interceptor plate 34 in the interceptor device 3 need to be replaced, the servo motor 10 is started by the control box 5 to drive the first frame 9 to tilt to a certain angle and raise the side closest to the feed hopper 8 to its highest position. At this time, when the first frame 9 rotates, it will drive the first round rod 45 to rotate on the bracket shell 7, and then drive the connecting rope 46 to wind up one end of the first round rod 45. The other end of the connecting rope 46 will drive the second round rod 48 to rotate to a certain position in the inner wall of the U-shaped block 47. The torsion spring 410 will deform between the second round rod 48 and the U-shaped block 47, so that one end will drive the gear 49 to rotate in the second rectangular hole 42 and the third rectangular hole 44, so that it drives the toothed plate 43 and the second filter screen 13 in the second rectangular groove. The first filter 41 slides to the end away from the inner wall of the support shell 7, allowing the original solution of Reganoxon injection that flows into the first filter screen 11 away from the feed hopper 8 to pass through the second filter screen 13 for secondary filtration. When it is replaced and rotated back, the connecting rope 46 will loosen and be released. Under the reset action of the torsion spring 410, the second round rod 48 will rotate, winding up the connecting rope 46 and driving the gear 49 to rotate, sliding the toothed plate 43 and the second filter screen 13 back to their original positions. Through the moving device 4, the second filter screen 13 can be moved back and forth in the second frame 12 according to the inclination of the first frame 9, so that it can always receive the original solution of Reganoxon injection filtered by the first filter screen 11 for secondary filtration. The top of the second round rod 48 is fixedly connected to the bearing 411, and the outer ring of the bearing 411 is fixedly connected to one side of the inner wall of the U-shaped block 47. By setting the bearing 411, the top of the second round rod 48 can be limited to one side of the inner wall of the U-shaped block 47, making it less prone to shaking and more stable when rotating.

[0061] Reference Figure 1-13 As shown, this embodiment discloses a pharmaceutical apparatus for using Reganoxon injection as described in any of the above-mentioned methods, comprising the following steps:

[0062] S1. When preparing Reganosine Injection, the required raw materials are prepared first and then put into a mixing container in a certain proportion and stirred evenly.

[0063] S2. Before filtering the original solution of Reganoxon injection, manually hold the handle block 38 to lock the first interceptor plate 32 into the slot 31 on the first frame 9, so that it is above the first filter screen 11. When filtering, the original solution of Reganoxon injection will first pass through the first interceptor plate 32 to intercept its impurities, and the original solution of Reganoxon injection will flow into the first filter screen 11 through the first interception hole 33 for further filtration.

[0064] S3. Then, pour the prepared Reganoxon injection stock solution into the feed hopper 8, and let it fall from the outlet of the feed hopper 8 onto the top of the first filter screen 11 for the first filtration. This can initially filter out large particulate impurities in the Reganoxon injection stock solution. Then, it falls through the filter holes on the first filter screen 11 onto the second filter screen 13 on the second frame 12 for the second filtration. The Reganoxon injection stock solution that has passed through the second filtration will be stored in the drug storage tank 1 at the bottom, and then discharged through the drug outlet valve pipe 6.

[0065] S4. When some impurities adhere to the wall of the feed hopper 8, the servo motor 10 can be activated to drive the first frame 9 and the first filter screen 11 to swing up and down at a certain arc. When one end of the first frame 9 moves downward, it presses against one side of the rotating rod 25, causing one end to move downward and tilt to a certain angle around the circular shaft 24 on the inner wall of the mounting block 22. The other end of the rotating rod 25 will cause the striking rod 26 to tilt, causing one end to strike the outer surface of the feed hopper 8, causing the feed hopper 8 to vibrate and shake off the impurities attached inside. As the first frame 9 moves upward at one end, it causes the rotating rod 25 to tilt to the other end, thereby causing the other end of the striking rod 26 to strike the protective block 215 on one end of the sliding rod 28. This causes the outer surface of the striking rod 26 to slide inward in the circular hole 27, pushing the second frame 12 to slide in the support shell 7. At the same time, the first spring 29 will contract between one side of the sliding rod 28 and one side of the support shell 7. When the first frame 9 again causes the striking rod 26 to strike the feed hopper 8, one end of the sliding rod 28 will lift up. Then, under the reset action of the first spring 29, it will... The sliding rod 28 slides outward, thereby causing the second frame 12 to slide to one side within the support shell 7. This back-and-forth sliding causes the internally installed second filter screen 13 to shake, accelerating the permeation and filtration of any unfiltered undiluted Reganoxon injection solution. When the rotating rod 25 rotates back and forth around the circular shaft 24, the two elastic blocks 214, pulled back and forth by the rotating rod 25, cause the sealing block 212 to slide back and forth within the first rectangular hole 23 and the first rectangular groove 210. Simultaneously, the telescopic rod 211 on one side and the first rectangular groove 210... The second spring 213 will stretch, contract and reset. The sealing block 212 and the elastic block 214 can seal and block both sides of the rotating rod 25, making it difficult for the filtered original liquid to overflow from the first rectangular hole 23. Then, by the continuous tapping of the tapping rod 26, the impurities attached to the inner wall of the feed hopper 8 will not accumulate and cause blockage of the feed hopper 8 outlet, affecting the subsequent filtration. At the same time, the tapping and vibration of the second frame 12 and the second filter screen 13 can accelerate the filtration efficiency of the original liquid of Reganosin injection attached to the second filter screen 13.

[0066] S5. When a large number of impurities are attached to the surface of the first interceptor plate 32 and it needs to be replaced, the servo motor 10 is started by the control box 5 to drive the first frame 9 to tilt to a certain angle and raise the side of it close to the feed hopper 8 to the highest point. Then, under the action of gravity, the first interceptor plate 32 will slide out of the slot 31 and fall out. Then, the new first interceptor plate 32 is manually installed in the slot 31 to continue filtering. This can reduce the replacement frequency of the first filter screen 11. At the same time, the easy-to-replace first interceptor plate 32 can reduce the replacement time and improve the filtration efficiency.

[0067] S6. When it is necessary to replace the first interceptor plate 32 and the second interceptor plate 34, the servo motor 10 will be started through the control box 5 to drive the first frame 9 to tilt to a certain angle and raise the side closest to the feed hopper 8 to its highest position. At this time, when the first frame 9 rotates, it will drive the first round rod 45 to rotate on the bracket shell 7, and then drive the connecting rope 46 to wind up one end of the first round rod 45. The other end of the connecting rope 46 will drive the second round rod 48 and the bearing 411 to rotate to a certain position in the inner wall of the U-shaped block 47. The torsion spring 410 will deform between the second round rod 48 and the U-shaped block 47, so that one end will drive the gear 49 to rotate in the second rectangular hole 42 and the third rectangular hole 44, so that it drives the toothed plate 43 and the second filter screen 13 in the second rectangular hole 42. The slid in the groove 41 to the end away from the inner wall of the support shell 7, so that the original liquid of Reganosheng injection that flows into the first filter screen 11 away from the feed hopper 8 passes through the second filter screen 13 for secondary filtration. When it is replaced and turned back, the connecting rope 46 will loosen and be released. Under the reset action of the torsion spring 410, the second round rod 48 will be driven to rotate and the connecting rope 46 will be wound up. The gear 49 will be driven to rotate and slide the toothed plate 43 and the second filter screen 13 back to the original position. Through the moving device 4, the second filter screen 13 can be moved back and forth in the second frame 12 to a certain position according to the inclination of the first frame 9, so that it can always receive the original liquid of Reganosheng injection filtered by the first filter screen 11 for secondary filtration.

[0068] S7. Finally, fill the filtered medicine into the cleaned ampoules, seal them, sterilize and package them after leak detection.

[0069] In addition, the present invention also provides a pharmaceutical preparation manufactured by the pharmaceutical equipment of the above-mentioned Reganoxon injection, an injection, a colorless and clear liquid with a pH value of 3.9-5.0, and containing 93.0%-103.0% of the labeled amount of Reganoxon.

[0070] The working principle is as follows: When preparing Reganoxon injection, the required raw materials are first prepared and then put into a mixing container in a certain proportion and stirred evenly. Before filtering the Reganoxon injection stock solution, the handle block 38 is manually held to lock the first interceptor plate 32 into the slot 31 on the first frame 9, so that it is positioned above the first filter screen 11. During filtration, the Reganoxon injection stock solution will first pass through the first interceptor plate 32 to intercept its impurities, and the Reganoxon injection stock solution will flow into the first filter screen 11 through the first interception hole 33. The solution is filtered again on filter screen 11; then the prepared concentrate of Reganoxen injection is poured into feed hopper 8, and then falls from the outlet of feed hopper 8 onto the top of the first filter screen 11 for the first filtration, which can initially filter out large particulate impurities in the concentrate of Reganoxen injection. Then it falls through the filter holes on the first filter screen 11 onto the second filter screen 13 on the second frame 12 for the second filtration. The concentrate of Reganoxen injection after the second filtration will be stored in the drug storage tank 1 at the bottom, and then discharged through the drug outlet valve pipe 6.When some impurities adhere to the wall of the feed hopper 8, the servo motor 10 can be activated to drive the first frame 9 and the first filter screen 11 to swing up and down at a certain arc. When one end of the first frame 9 moves downward, it presses against one side of the rotating rod 25, causing one end to move downward and tilt to a certain angle around the circular shaft 24 on the inner wall of the mounting block 22. The other end of the rotating rod 25 will cause the striking rod 26 to tilt, causing one end to strike the outer surface of the feed hopper 8, causing the feed hopper 8 to vibrate and shake off the impurities attached inside. Then, when one end of the first frame 9 moves upward, it will cause the rotating rod 25 to tilt to the other end, thereby causing the other end of the striking rod 26 to strike. The impact strikes the protective block 215 at one end of the slide rod 28, causing its outer surface to slide inward through the circular hole 27, pushing the second frame 12 to slide within the support shell 7. Simultaneously, the first spring 29 contracts between one side of the slide rod 28 and one side of the support shell 7. When the first frame 9 again drives the striking rod 26 to strike the feed hopper 8, one end of the slide rod 28 will lift up. Then, under the reset action of the first spring 29, the slide rod 28 will slide outward, thereby causing the second frame 12 to slide to one side within the support shell 7. This back-and-forth sliding causes the internally installed second filter screen 13 to shake, accelerating the permeation and filtration of any unpermeated Reganoxon injection solution from its surface. When the rotating rod 25 rotates back and forth around the circular shaft 24, the two elastic blocks 214, pulled back and forth by the rotating rod 25, will cause the sealing block 212 to slide back and forth in the first rectangular hole 23 and the first rectangular groove 210. At the same time, the telescopic rod 211 and the second spring 213 on one side will stretch, contract and return to their original positions. The sealing block 212 and the elastic block 214 can seal and block both sides of the rotating rod 25, making it difficult for the filtered raw liquid to overflow from the first rectangular hole 23. Then, through the continuous tapping of the tapping rod 26, impurities adhering to the inner wall of the feed hopper 8 can be prevented from accumulating and causing blockage at the outlet of the feed hopper 8, thus affecting subsequent filtration. At the same time, the second frame 12 and The second filter screen 13 is vibrated by tapping, which can accelerate the filtration efficiency of the original solution of Reganosine injection attached to the second filter screen 13. When a large amount of impurities are attached to the surface of the first interceptor plate 32 and it needs to be replaced, the servo motor 10 is started by the control box 5 to drive the first frame 9 to tilt to a certain angle and raise the side of it close to the feed hopper 8 to the highest point. Then, under the action of gravity, the first interceptor plate 32 will slide out of the slot 31 and fall out. Then, the new first interceptor plate 32 is manually installed in the slot 31 to continue filtration. This can reduce the replacement frequency of the first filter screen 11. At the same time, the easy-to-replace first interceptor plate 32 can reduce the replacement time and improve the filtration efficiency.When the first interceptor plate 32 and the second interceptor plate 34 need to be replaced, the servo motor 10 is started by the control box 5 to drive the first frame 9 to tilt to a certain angle and raise the side closest to the feed hopper 8 to its highest position. At this time, when the first frame 9 rotates, it will drive the first round rod 45 to rotate on the bracket shell 7, and then drive the connecting rope 46 to wind up one end of the first round rod 45. The other end of the connecting rope 46 will drive the second round rod 48 and the bearing 411 to rotate to a certain position in the inner wall of the U-shaped block 47. The torsion spring 410 will deform between the second round rod 48 and the U-shaped block 47, so that one end will drive the gear 49 to rotate in the second rectangular hole 42 and the third rectangular hole 44, so that it drives the toothed plate 43 and the second filter screen 13 in the second rectangular groove 4. The filter 1 slides to the end furthest from the inner wall of the support shell 7, allowing the original solution of Reganoxon injection flowing into the first filter screen 11 furthest from the feed hopper 8 to pass through the second filter screen 13 for secondary filtration. When it is replaced and rotated back, the connecting rope 46 will loosen and be released. Under the reset action of the torsion spring 410, the second round rod 48 will rotate, winding up the connecting rope 46 and driving the gear 49 to rotate, sliding the toothed plate 43 and the second filter screen 13 back to their original positions. Through the moving device 4, the second filter screen 13 can be moved back and forth in the second frame 12 to a certain position according to the inclination of the first frame 9, so that it can always receive the original solution of Reganoxon injection filtered by the first filter screen 11 for secondary filtration.

Claims

1. A pharmaceutical device for regadenoson injection solution, comprising a drug storage tank (1) and a second filter screen (13), characterized in that: One side of the medicine storage tank (1) is fixedly connected with the control box (5), one side of the medicine storage tank (1) is provided with the medicine outlet valve pipe (6), the top of the medicine storage tank (1) is fixedly connected with the support shell (7), the top of the support shell (7) is fixedly connected with the feed hopper (8), the inner wall of the support shell (7) is rotatably connected with the first frame (9), one side of the first frame (9) is fixedly connected with the servo motor (10), one side of the servo motor (10) is fixedly connected with one side of the support shell (7), the output end outer surface of the servo motor (10) is connected with one side of the support shell (7), the inner wall of the first frame (9) is provided with the first filter screen (11), the inner wall of the support shell (7) is slidably connected with the second frame (12), one side of the support shell (7) is provided with the knocking device (2), one side of the first frame (9) is provided with the intercepting device (3), the inner wall of the second frame (12) and the outer surface of the second filter screen (13) are provided with the moving device (4). The knocking device (2) comprises a mounting block (22), one side of the support shell (7) is provided with a mounting hole (21), the inner wall of the mounting hole (21) is fixedly connected with the outer surface of the mounting block (22), one side of the mounting block (22) is provided with a first rectangular hole (23), the inner wall of the first rectangular hole (23) is rotatably connected with a round shaft (24), the outer surface of the round shaft (24) is fixedly connected with a rotating rod (25), the end of the rotating rod (25) close to the first frame (9) is chamfered on both sides, the size and shape of the outer surface of the rotating rod (25) are matched with the size and shape of the inner wall of the first rectangular hole (23), one side of the rotating rod (25) is fixedly connected with a knocking rod (26), one side of the support shell (7) is provided with a round hole (27), the inner wall of the round hole (27) is slidably connected with a sliding rod (28), one side of the sliding rod (28) is fixedly connected with one side of the first frame (9), the outer surface of the sliding rod (28) is sleeved with a first spring (29), the two ends of the first spring (29) are fixedly connected with one side of the support shell (7) and one side of the sliding rod (28) respectively, the two ends of the knocking rod (26) are close to one side of the feeding hopper (8) and the sliding rod (28), the inner wall of the first rectangular hole (23) is provided with a first rectangular groove (210) on both sides, the inner wall of the first rectangular groove (210) is fixedly connected with an extension rod (211), one end of the extension rod (211) is fixedly connected with a sealing block (212), the periphery of the sealing block (212) is slidably connected with the inner wall of the first rectangular groove (210) and the first rectangular hole (23), the outer surface of the extension rod (211) is sleeved with a second spring (213), the two ends of the second spring (213) are fixedly connected with the inner wall of the first rectangular groove (210) and the sealing block (212) respectively, one side of the sealing block (212) is fixedly connected with an elastic block (214), one side of the elastic block (214) is fixedly connected with one side of the rotating rod (25); when one end of the first frame (9) moves downward, it is pressed on one side of the rotating rod (25), drives the downward movement of one end to tilt to a certain angle on the inner wall of the mounting block (22) with the round shaft as the center, the other end of the rotating rod (25) drives the knocking rod (26) to tilt, so that one end of the knocking rod (26) knocks on the outer surface of the feeding hopper (8), so that the feeding hopper (8) vibrates to shake off the impurities attached in the feeding hopper (8).

2. A pharmaceutical plant for regadenoson injection according to claim 1, characterized in that: The longitudinal section of the elastic block (214) is wrinkle-shaped, and the elastic block (214) is made of silica gel.

3. A pharmaceutical plant for regadenoson injection according to claim 2, characterized in that: One side of the sliding rod (28) is fixedly connected with a protection block (215), and the protection block (215) is made of rubber.

4. A pharmaceutical device for a Regadenoson injection solution as defined in claim 3, characterized in that: The intercepting device (3) comprises a first intercepting plate (32), one side of the first frame (9) is provided with a clamping groove (31), the inner wall size and shape of the clamping groove (31) are matched with the outer surface size and shape of the first intercepting plate (32), the outer surface of the first intercepting plate (32) is provided with a plurality of first intercepting holes (33), and the clamping groove (31) is arranged above the first filter screen (11).

5. A pharmaceutical plant for the preparation of Regadenoson injection according to claim 4, characterized in that: The intercepting device (3) further comprises a second intercepting plate (34), the outer surface size and shape of the second intercepting plate (34) are matched with the inner wall size and shape of the clamping groove (31), one side of the second intercepting plate (34) is provided with a plurality of circular grooves (35), the inner wall of the circular groove (35) is provided with a plurality of second intercepting holes (37), one side of the second intercepting plate (34) is provided with a plurality of drainage grooves (36) around the circular groove (35), the inner wall bottom of the drainage groove (36) is an inclined surface, and the plurality of drainage grooves (36) are arranged at equal distances.

6. A pharmaceutical device for a Regadenoson injection solution as defined in claim 5, characterized in that: One side of the first intercepting plate (32) and the second intercepting plate (34) is fixedly connected with a handle block (38), and the cross section of the handle block (38) is in U shape.

7. A pharmaceutical plant for the production of Regadenoson injection according to claim 6, characterized in that: The moving device (4) comprises a toothed plate (43), the inner wall of the second frame (12) is symmetrically provided with a second rectangular groove (41), the inner wall of the second rectangular groove (41) is slidably connected with the two sides of the second filter screen (13), the inner wall of one of the second rectangular grooves (41) is provided with a second rectangular hole (42), one side of the toothed plate (43) is fixedly connected with one side of the second filter screen (13), the two sides of the toothed plate (43) are slidably connected with the inner wall of the second rectangular groove (41), one side of the support shell (7) is provided with a third rectangular hole (44), the side, away from the servo motor (10), of the first frame (9) is fixedly connected with a first circular rod (45), the outer surface of the first circular rod (45) is penetratingly connected with one side of the support shell (7), the outer surface of the first circular rod (45) is fixedly connected with a connecting rope (46), one side of the support shell (7) is fixedly connected with a U-shaped block (47), the inner wall side of the U-shaped block (47) is penetratingly connected with a second circular rod (48), one end of the second circular rod (48) is fixedly connected with a gear (49), the outer surface of the gear (49) is engaged with one side of the toothed plate (43), the inner wall sizes of the second rectangular hole (42) and the third rectangular hole (44) are matched with the outer surface size of the gear (49), the outer surface of the second circular rod (48) is sleevedly connected with a torsional spring (410), and the two ends of the torsional spring (410) are fixedly connected with one side of the U-shaped block (47) and the top of the gear (49) respectively.

8. A pharmaceutical device for a Regadenoson injection solution according to claim 7, characterized in that: The top of the second circular rod (48) is fixedly connected with a bearing (411), and the outer ring of the bearing (411) is fixedly connected with one side of the inner wall of the U-shaped block (47).

9. A method characterized by: The pharmaceutical device for the regadenoson injection of any one of claims 1-8 comprises the following steps: The pharmaceutical device for the regadenoson injection of any one of claims 1-8 comprises the following steps: S1, in the preparation of Regadenoson injection, the required raw materials are prepared and put into the proportioning container in a certain proportion for stirring; S2, before filtering the stock solution of Regadenoson injection, first manually hold the handle block (38) to make the first intercepting plate (32) be clamped in the clamping groove (31) on the first frame (9) above the first filter screen (11), so that the impurities in the stock solution of Regadenoson injection can be intercepted by the first intercepting plate (32) during filtering, and the stock solution of Regadenoson injection can flow through the first intercepting hole (33) into the first filter screen (11) for re-filtering; S3, then pour the proportioned stock solution of Regadenoson injection into the feed hopper (8), and then let it fall from the outlet of the feed hopper (8) onto the top of the first filter screen (11) for the first filtering, so that the large-particle impurities in the stock solution of Regadenoson injection can be preliminarily filtered out, and then fall through the filter holes on the first filter screen (11) onto the second filter screen (13) on the second frame (12) for the second filtering, and the stock solution of Regadenoson injection filtered out after the second filtering can be stored in the medicine storage tank (1) at the bottom, and then discharged by the medicine outlet valve pipe (6); S4, when part of the impurities adhere to the wall of the hopper (8), the servo motor (10) can be started to drive the first frame (9) and the first filter screen (11) to swing up and down by a certain radian, one end of the first frame (9) presses on one side of the rotating rod (25) when moving downward, drives the one end to move downward to tilt to a certain angle on the inner wall of the mounting block (22) with the circular shaft (24) as the center, the other end of the rotating rod (25) drives the knocking rod (26) to tilt, so that one end of the knocking rod (26) knocks on the outer surface of the hopper (8), causing the hopper (8) to vibrate and shake off the impurities attached inside, then when one end of the first frame (9) moves upward, it drives the rotating rod (25) to tilt to the other end, thereby driving the other end of the knocking rod (26) to knock on the protective block (215) on one end of the sliding rod (28), causing the outer surface to slide inward in the circular hole (27) to push the second frame (12) to slide in the support shell (7), at the same time, the first spring (29) contracts between one side of the sliding rod (28) and one side of the support shell (7), when the first frame (9) drives the knocking rod (26) to knock the hopper (8) again, one end of the sliding rod (28) will be raised, then under the reset action of the first spring (29), the sliding rod (28) slides outward, thereby driving the second frame (12) to slide to one side in the support shell (7), the second filter screen (13) inside the second frame (12) will shake to accelerate the penetration of the raw liquid of Reganosheng injection that has not been fully penetrated on the surface of the second filter screen (13), when the rotating rod (25) rotates back and forth with the circular shaft (24) as the center, the two elastic blocks (214) will slide back and forth in the first rectangular hole (23) and the first rectangular groove (210) under the pulling of the rotating rod (25), at the same time, the telescopic rod (211) on one side of the sealing block (212) and the second spring (213) will stretch and contract to reset, the sealing block (212) and the elastic block (214) can seal the two sides of the rotating rod (25) to prevent the raw liquid from overflowing from the first rectangular hole (23), then through the continuous knocking of the knocking rod (26), the impurities attached to the inner wall of the hopper (8) are not easy to accumulate to cause the hopper (8) to be blocked, thereby affecting the later filtration, at the same time, the second frame (12) and the second filter screen (13) are knocked and vibrated to accelerate the filtration efficiency of the raw liquid of Reganosheng injection attached to the second filter screen (13). S5、When a large amount of impurities adheres to the surface of the first intercepting plate (32) and needs to be replaced, the servo motor (10) is started through the control box (5) to tilt the first frame (9) to a certain angle, and then the side close to the feed hopper (8) is lifted to the highest. Then under the action of gravity, the first intercepting plate (32) will slide out of the clamping groove (31) and fall out. Then the new first intercepting plate (32) is manually installed in the clamping groove (31) to continue filtering, so that the replacement frequency of the first filter screen (11) can be reduced, and the replacement time of the first intercepting plate (32) can be reduced, and the filtering efficiency can be improved; S6、When the first intercepting plate (32) and the second intercepting plate (34) need to be replaced, the servo motor (10) is started through the control box (5) to tilt the first frame (9) to a certain angle, and then the side close to the feed hopper (8) is lifted to the highest. At this time, the first frame (9) will drive the first round rod (45) to rotate on the support shell (7) when rotating, and then drive the connecting rope (46) to wind at one end of the first round rod (45). The other end of the connecting rope (46) drives the second round rod (48) and the bearing (411) to rotate to a certain position in the inner wall of the U-shaped block (47), and the torsional spring (410) will deform between the second round rod (48) and the U-shaped block (47), so that one end will drive the gear (49) to rotate in the second rectangular hole (42) and the third rectangular hole (44), so that it drives the toothed plate (43) and the second filter screen (13) to slide in the second rectangular groove (41) away from the inner wall of the support shell (7) to the corresponding position, so that it flows into the raw liquid of the Reganol injection away from the feed hopper (8) The end of the first filter screen (11) passes through the second filter screen (13) again to perform secondary filtering. When it is turned back after replacement, the connecting rope (46) will be loose and released. Under the reset action of the torsional spring (410), the second round rod (48) will rotate to wind up the connecting rope (46), and the gear (49) will rotate to slide the toothed plate (43) and the second filter screen (13) back to the original position. Through the moving device (4), the second filter screen (13) can be moved back and forth in the second frame (12) to a certain position according to the inclination of the first frame (9), so that it can always filter the raw liquid of the Reganol injection filtered by the first filter screen (11) to perform secondary filtering; S7、Finally, the filtered liquid medicine is filled in the cleaned ampoule, sealed, sterilized, and packaged.

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