Implantable flexible assembly, detection system and method of operation thereof

Abstract

The application provides an implantable flexible assembly, a detection system and an operation method. The implantable flexible assembly comprises a first flexible substrate, a second flexible substrate and a plurality of insulating spacers. The first flexible substrate is provided with a plurality of first connecting lines, an array of a plurality of first bonding parts and an array of a plurality of first electrodes. The second flexible substrate is provided with a plurality of second connecting lines, an array of a plurality of second bonding parts and an array of a plurality of second electrodes. The plurality of insulating spacers are one-to-one correspondingly arranged on the plurality of first electrodes or the plurality of second electrodes. The first flexible substrate is attached to the second flexible substrate. The plurality of first bonding parts and the plurality of second bonding parts are one-to-one correspondingly and mutually inserted. Each insulating spacer is located between the corresponding first electrode and the corresponding second electrode. The application can prolong the overall service life of the implantable flexible assembly.

Description

Technical Field

[0001] This invention relates to the field of biological tissue detection, and in particular to an implantable flexible component, an implantable flexible biological tissue detection system, and its operating method. Background Technology

[0002] Currently, implantable medical devices are widely used in biomedical fields such as diagnosis, treatment, and organ repair. However, the surfaces of these implantable medical devices are frequently subjected to irreversible biofouling. Specifically, contaminants include proteins, enzymes, and metabolites. During long-term operation of implantable medical devices, biofouling will irreversibly adhere to their working surfaces, gradually altering the electrochemical and biological properties of these devices, leading to unpredictable device malfunctions and serious infections. Biofouling is contamination of surfaces caused by the adhesion of organisms and their byproducts. Biofouling on the surface of implantable medical devices is caused by the adhesion of microorganisms or thrombotic mediators resulting from foreign body reactions. Biofouling limits the lifespan of implanted medical devices and may even lead to their removal and replacement.

[0003] Therefore, improving the overall lifespan of implantable medical devices, especially implantable flexible components, is one of the technical problems that need to be solved in this field. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention provides an implantable flexible component, an implantable flexible biological tissue detection system, and a method for operating the same.

[0005] To achieve the above objectives, the present invention provides an implantable flexible component comprising a first flexible substrate and a second flexible substrate. A first flexible substrate is provided with multiple first connecting lines, multiple first joints arranged in an array, and multiple first electrodes arranged in an array. The multiple first electrodes correspond one-to-one with the multiple first joints, and each first electrode surrounds a corresponding first joint. The multiple first connecting lines are connected one-to-one with the multiple first electrodes. A second flexible substrate is provided with multiple second connecting lines, multiple second joints arranged in an array, and multiple second electrodes arranged in an array. The multiple second electrodes correspond one-to-one with the multiple second joints, and each second electrode surrounds a corresponding second joint. The multiple second connecting lines are connected one-to-one with the multiple second electrodes. One of the first joints and the corresponding second joint is a protrusion, and the other is a groove. Multiple insulating spacers are disposed one-to-one on the multiple first electrodes or one-to-one on the multiple second electrodes. In a first mode, the first flexible substrate covers and adheres to the second flexible substrate. The multiple first joints correspond one-to-one with the multiple second joints and are interlocked with each other. Each insulating spacer is located between a corresponding first electrode and a corresponding second electrode.

[0006] As an optional technical solution, the plurality of first joints are plurality of protrusions, the plurality of first electrodes and the corresponding first joints are integrally formed on the first flexible substrate and each first joint protrudes from the corresponding first electrode, the plurality of second joints are plurality of grooves that match the plurality of protrusions, and the aperture of the plurality of second electrodes is larger than the aperture of the corresponding second joint.

[0007] As an optional technical solution, the plurality of insulating spacers are disposed one-to-one on the plurality of first electrodes, and the implantable flexible component further includes a third flexible substrate. The third flexible substrate is matched with the plurality of second connecting lines, the plurality of second bonding portions, and the plurality of second electrodes by a plurality of third connecting lines, a plurality of third bonding portions arranged in an array, and a plurality of third electrodes arranged in an array. The plurality of third electrodes correspond one-to-one with the plurality of third bonding portions, and each third electrode surrounds a corresponding third bonding portion. The plurality of third connecting lines are connected one-to-one with the plurality of third electrodes. One of the third bonding portions and one of the corresponding second bonding portions is a protrusion, and the other is a groove. In a second mode, the first flexible substrate is removed from the second flexible substrate, the third flexible substrate covers and adheres to the second flexible substrate, and the plurality of third bonding portions correspond one-to-one with the plurality of second bonding portions and are mutually bonded. The plurality of third electrodes correspond one-to-one with the plurality of second electrodes and are in electrical contact with each other.

[0008] Furthermore, the present invention also proposes an implantable flexible biological tissue detection system, which includes the aforementioned implantable flexible component and a data processing component. In the first mode, the data processing component is electrically connected to the plurality of first connection lines and the plurality of second connection lines to transmit electrical signals with the plurality of first connection lines and the plurality of second connection lines.

[0009] As an optional technical solution, the data processing component pre-stores a first threshold range. The data processing component is used to receive multiple first electrical signals from the multiple first connection lines and the multiple second connection lines, compare the multiple first electrical signals with the first threshold range one by one, and classify the area formed by the first electrode and the second electrode corresponding to the first electrical signal that exceeds the first threshold range as an abnormal area.

[0010] As an optional technical solution, the plurality of insulating spacers are correspondingly disposed on the plurality of first electrodes. The implanted flexible component further includes a third flexible substrate. The third flexible substrate is provided with a plurality of third connecting lines, a plurality of third joints arranged in an array, and a plurality of third electrodes arranged in an array, corresponding to the plurality of second connecting lines, the plurality of second joints, and the plurality of second electrodes. The plurality of third electrodes correspond one-to-one with the plurality of third joints, and each third electrode surrounds a corresponding third joint. The plurality of third connecting lines are connected one-to-one with the plurality of third electrodes. In the second mode, the first flexible substrate is removed from the second flexible substrate, and the third flexible substrate covers and adheres to the second flexible substrate. The plurality of third joints correspond one-to-one with the plurality of second joints and are joined to each other. The plurality of third electrodes correspond one-to-one with the plurality of second electrodes and are electrically in contact with each other. In the second mode, the data processing component is electrically connected to the plurality of second connecting lines and the plurality of third connecting lines to transmit at least one second electrical signal to the third electrode and the second electrode in the abnormal area.

[0011] As an optional technical solution, the implantable flexible biological tissue detection system further includes a membrane connection assembly, which includes a proximal end and a distal end of a membrane adapter that are interlocked with each other. The proximal end of the membrane adapter is connected to the data processing component via a wire, and the distal end of the membrane adapter is connected to the plurality of first connection lines and the plurality of second connection lines via a wire in the first mode, and to the plurality of third connection lines and the plurality of second connection lines via a wire in the second mode.

[0012] Furthermore, the present invention also proposes an operation method for an implantable flexible biological tissue detection system, which includes providing the aforementioned implantable flexible component; attaching a first flexible substrate to the surface of a target biological tissue; covering and attaching the first flexible substrate to a second flexible substrate; wherein the plurality of first joints correspond one-to-one with the plurality of second joints and are interlocked with each other; and each insulating spacer is located between a corresponding first electrode and a corresponding second electrode.

[0013] As an optional technical solution, the implantable flexible biological tissue detection system further includes a data processing component, which pre-stores a first threshold range; the operation method further includes electrically connecting the data processing component to the plurality of first connection lines and the plurality of second connection lines, wherein the data processing component receives a plurality of first electrical signals from the plurality of first connection lines and the plurality of second connection lines, compares the plurality of first electrical signals with the first threshold range one by one, and classifies the regions formed by the first electrode and the second electrode corresponding to the first electrical signals that exceed the first threshold range as abnormal regions.

[0014] As an optional technical solution, the plurality of insulating spacers are correspondingly disposed on the plurality of first electrodes. The implanted flexible component further includes a third flexible substrate. The third flexible substrate is provided with a plurality of third connecting lines, a plurality of third joints arranged in an array, and a plurality of third electrodes arranged in an array, corresponding to the plurality of second connecting lines, the plurality of second joints, and the plurality of second electrodes. The plurality of third electrodes correspond one-to-one with the plurality of third joints, and each third electrode surrounds a corresponding third joint. The plurality of third connecting lines are connected one-to-one with the plurality of third electrodes. The operation method further includes removing the first flexible substrate from the second flexible substrate, covering and attaching the third flexible substrate to the second flexible substrate, with the plurality of third joints corresponding one-to-one with the plurality of second joints and engaging with each other, the plurality of first electrodes corresponding one-to-one with the plurality of second electrodes and each in electrical contact, and electrically connecting the data processing component to the plurality of second connecting lines and the plurality of third connecting lines. The data processing component transmits at least one second electrical signal to the third electrode and the second electrode in the abnormal area.

[0015] In this invention, a plurality of first joints and a plurality of second joints are respectively provided on the first flexible substrate and the second flexible substrate. During the process of the first flexible substrate covering and attaching to the second flexible substrate, the mutual matching of the plurality of first joints and the corresponding second joints ensures the precise alignment / positioning of the first and second flexible substrates. After the first flexible substrate covers and attaches to the second flexible substrate, the first and second flexible substrates can encapsulate the plurality of first electrodes, the plurality of second electrodes, etc., thereby reducing or even avoiding contamination of the electrodes when the first and second flexible substrates are implanted in the body or attached to the surface of the target biological tissue, and extending the overall service life of the implantable flexible component. Furthermore, the mechanical engagement between the plurality of first joints and the corresponding second joints helps to reliably fix the first flexible substrate to the second flexible substrate, ensuring the stability of the implantable flexible component during use and ensuring the accuracy of the detection results. Attached Figure Description

[0016] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0017] Figure 1 This is a partial cross-sectional schematic diagram of the implantable flexible component of the present invention in a first mode; Figure 2 for Figure 1 A partial cross-sectional view of the implanted flexible component before bonding in the first mode; Figure 3A for Figure 2 Top view of the first flexible substrate; Figure 3B for Figure 2 Top view of the second flexible substrate; Figure 4 This is a partial cross-sectional schematic diagram of the implantable flexible component of the present invention in a second mode; Figure 5 for Figure 4 A partial cross-sectional view of the implanted flexible component before bonding in the second mode; Figure 6 for Figure 5 Top view of the third flexible substrate; Figure 7 This is a schematic diagram of the implantable flexible biological tissue detection system of the present invention. Detailed Implementation

[0018] To provide a further understanding of the purpose, structure, features, and functions of the present invention, detailed descriptions are provided below with reference to specific embodiments.

[0019] In the description of this invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0020] Please refer to Figures 1 to 3B , Figure 1 This is a partial cross-sectional schematic diagram of the implantable flexible component of the present invention. Figure 2 for Figure 1 A partial cross-sectional view of the implanted flexible component before bonding. Figure 3A for Figure 2 Top view of the first flexible substrate. Figure 3B for Figure 2A top view of the second flexible substrate. The implantable flexible component 100 of the present invention includes a first flexible substrate 110, a second flexible substrate 120, and a plurality of insulating spacers ins. The first flexible substrate 110 is provided with a plurality of first junctions 111 arranged in an array, a plurality of first electrodes 112 arranged in an array, and a plurality of first connecting lines 113. The plurality of first electrodes 112 correspond one-to-one with the plurality of first junctions 111, and each first electrode 112 surrounds the corresponding first junction 111. The plurality of first connecting lines 113 are connected one-to-one with the plurality of first electrodes 112, so that when the first flexible substrate 110 is implanted in the body / attached to the surface of the target biological tissue, the plurality of first electrodes 112 can transmit signals to an external controller (e.g., a data processing component 200, which will be described in detail later) via the plurality of first connecting lines 113.

[0021] On the second flexible substrate 120, corresponding to the multiple first joints 111, multiple first electrodes 112, and multiple first connecting lines 113 on the first flexible substrate 110, multiple second joints 121, multiple second electrodes 122, and multiple second connecting lines 123 are arranged in an array. The multiple second electrodes 122 correspond one-to-one with the multiple second joints 121, and each second electrode 122 surrounds the corresponding second joint 121. The multiple second connecting lines 123 are connected one-to-one with the multiple second electrodes 122, so that when the second flexible substrate 120 is implanted in the body / attached to the surface of the target biological tissue, the multiple second electrodes 122 can transmit signals to an external controller (e.g., a data processing component 200, which will be described in detail later) via the multiple second connecting lines 123.

[0022] Furthermore, the implantable flexible component 100 also includes multiple insulating spacers ins, which can be disposed one-to-one with multiple first electrodes 112 or one-to-one with multiple second electrodes 122. In this embodiment, as... Figure 2 As shown, multiple insulating spacers ins are disposed one-to-one on multiple first electrodes 112. In actual operation, this is not the only limitation.

[0023] In the first mode, after the second flexible substrate 120 (specifically, the surface of the second flexible substrate 120 without the second junction 121 and the second electrode 122) is implanted into the body, it adheres to the surface of the target biological tissue. Then, the first flexible substrate 110 covers and adheres to the second flexible substrate 120, and the plurality of first junctions 111 correspond one-to-one with the plurality of second junctions 121 and are interlocked with each other. Each insulating spacer position ins is located between the corresponding first electrode 112 and the corresponding second electrode 122. In other words, the plurality of first electrodes 112, the plurality of insulating spacers, and the plurality of second electrodes 122 correspond one-to-one to form a plurality of capacitors (or capacitor arrays) arranged in an array.

[0024] In this invention, a plurality of first joint portions 111 and a plurality of second joint portions 121 are respectively provided on the first flexible substrate 110 and the second flexible substrate 120. During the process of the first flexible substrate 110 covering and attaching to the second flexible substrate 120, the mutual matching of the plurality of first joint portions 111 and the corresponding second joint portions 121 ensures the precise alignment / positioning of the first flexible substrate 110 and the second flexible substrate 120. After the first flexible substrate 110 covers and attaches to the second flexible substrate 120, the first flexible substrate 110 and the second flexible substrate 120 can encapsulate sensitive electronic components such as a plurality of first electrodes 112 and a plurality of second electrodes 122, so that when the first flexible substrate 110 and the second flexible substrate 120 are implanted in the body / attached to the surface of the target biological tissue, the electrodes on them can be reduced or even avoided from being contaminated, thus extending the overall service life of the implantable flexible component 100. Furthermore, the mechanical engagement between the multiple first joints 111 and the corresponding second joints 121 helps to reliably fix the first flexible substrate 110 onto the second flexible substrate 120, ensuring the stability of the implanted flexible component 100 during use and ensuring the accuracy of subsequent test results.

[0025] Furthermore, such as Figure 3A and Figure 3B As shown, the first flexible substrate 110 may not have the first bonding portion 111 and the first electrode 121 near its edge. Correspondingly, the second flexible substrate 120 may not have the second bonding portion 121 and the second electrode 122 near its edge. In this way, when the first flexible substrate 110 covers and adheres to the second flexible substrate 120, the areas of the first flexible substrate 110 and the second flexible substrate 120 near their edges can adhere to each other, further ensuring that multiple sensitive electronic components such as the first electrode 112 and the second electrode 122 are encapsulated therein. When the implantable flexible component 100 is placed in the patient's body / attached to the surface of the target biological tissue, it can avoid contact / reaction with internal contaminants, such as proteins, with the electrodes on the flexible substrate, thereby ensuring the long-term stability of the implantable flexible component 100 and extending the overall service life of the implantable flexible component 100.

[0026] In one embodiment, the first flexible substrate 110 and the second flexible substrate 120 may be made of a flexible polymer material with antifouling properties, such as one or any combination of treated polydimethylsiloxane (PDMS), zwitteinsionic polymeins, neutinsal polymeins, polyelectinsolytes, amphiphilic polymeins, quaternary ammonium polymeins, biopolymeins, hydinsophilic polymeins, polydopamine, and hydrogels. Thus, when the first flexible substrate 110 and the second flexible substrate 120 are implanted in the body or attached to the surface of the target biological tissue, they can reduce the adhesion of biological dirt and / or inhibit the proliferation and growth of microorganisms on the surface of the first flexible substrate 110 and / or the second flexible substrate 120, thereby protecting the sensitive electronic components such as the first electrode 112 and the second electrode 122 that they encapsulate and extending the lifespan of the implantable flexible component 100.

[0027] like Figures 1 to 3B As shown, multiple first joints 111 are disposed corresponding to multiple first electrodes 112, and each first electrode 112 surrounds the corresponding first joint 111. Therefore, the vertical projection of the multiple first joints 111 onto the first flexible substrate 110 is smaller than the vertical projection of the corresponding first electrode 112 onto the first flexible substrate 110, for example, smaller than half the diameter of the corresponding first electrode 112. Multiple second joints 121 are disposed corresponding to multiple second electrodes 122, and each second electrode 122 surrounds the corresponding second joint 121. Therefore, the vertical projection of the multiple second joints 121 onto the second flexible substrate 120 is smaller than the vertical projection of the corresponding second electrode 122 onto the second flexible substrate 120, for example, smaller than half the diameter of the corresponding second electrode 122.

[0028] like Figure 3A and Figure 3B As shown, the outer contours of the first electrode 112 and the second electrode 122 are circular. Multiple first joints 111 correspond to the central region of the first electrode 112, and multiple second joints 121 correspond to the central region of the second electrode 122. Both the first electrode 112 and the second electrode 122 have annular structures, but this is not a limitation. The outer contours of the first electrode 112 and the second electrode 122 can also be square, hexagonal, or other shapes. Figure 3A and Figure 3BAs shown, in this embodiment, the outlines of the first joint 111 and the second joint 121 are circular, but not limited thereto, they can also be square, hexagonal or other shapes.

[0029] In one embodiment, in addition to being provided for each electrode, the plurality of first joints 111 / the plurality of second joints 121 may also be provided in the area on the first flexible substrate 110 where the first electrode 112 is not provided, and the second flexible substrate 120 may be provided with corresponding matching second joints 121 to further assist in the alignment and mechanical fixation of the first flexible substrate 110 and the second flexible substrate 120.

[0030] like Figure 3A As shown, the first column of first electrodes 112 and the second column of first electrodes 112 arranged adjacent to each other along the first direction F1 are not aligned along the second direction F2, and the first direction F1 intersects the second direction F2. In this embodiment, the first direction F1 is perpendicular to the second direction F2, but this is not a limitation. By arranging the electrodes in an alternating manner with adjacent columns, the electrode density can be increased, thereby improving the accuracy of the implantable flexible component 100.

[0031] In actual operation, each first joint 111 and its corresponding second joint 121 consists of one protrusion and the other a groove. In this embodiment, as shown... Figure 1 and Figure 2 As shown, the plurality of first joint portions 111 can be a plurality of protrusions disposed on the first flexible substrate 110, and the plurality of second joint portions 121 can be a plurality of grooves disposed on the second flexible substrate 120 for insertion and engagement with the plurality of first joint portions 111. In other embodiments, not limited thereto, the plurality of first joint portions 111 can also be a plurality of grooves disposed on the first flexible substrate 110, and the plurality of second joint portions 121 can be a plurality of protrusions that match the plurality of grooves. Figure 1 and Figure 2 As shown, the multiple grooves are blind holes that do not penetrate the second flexible substrate 120. Thus, the surface of the second flexible substrate 120 without the second junction 121 and the second electrode 122 is a complete surface. When the second flexible substrate 120 is implanted in the body, this complete surface adheres to the surface of the target biological tissue. In one embodiment, the depth of the groove is greater than half and less than four-fifths of the thickness of the second flexible substrate 120. This ensures that the groove has sufficient depth to guarantee the subsequent bonding effect with the first junction 111, and also ensures the structural strength of the second flexible substrate 120 at the groove, preventing damage to the second flexible substrate 120 during subsequent implantation and removal from the body.

[0032] In one embodiment, a plurality of first electrodes 112 and corresponding first junctions 111 can be integrally formed on the surface of a first flexible substrate 110, with each first junction 111 protruding from its corresponding first electrode 112. Each first electrode 112 and its corresponding first junction 111 can be integrally formed into a rivet-like structure, wherein the first electrode 112 is the bottom of the rivet-like structure, and the corresponding first junction 111 is the columnar portion (or micropillar) of the rivet-like structure. In this case, the plurality of first electrodes 112 and the plurality of first junctions 111 can all be made of metallic materials, such as gold, platinum, or platinum-iridium for the rivet-like structure.

[0033] In one embodiment, when fabricating the first flexible substrate 110, an array of metal rivet-like structures arranged in the aforementioned manner can be formed on the surface of the first flexible substrate 110 using precision processing techniques such as micro-nano fabrication. This allows multiple first joints 111 and multiple first electrodes 112 to be formed simultaneously in a single process, simplifying the fabrication process. Then, insulating spacers ins are formed on the surface of each first electrode 112. When fabricating the second flexible substrate 120, an array of grooves (or micropores) matching the array of rivet-like structures and second electrodes 122 surrounding the corresponding grooves can also be formed on the second flexible substrate 120 using precision processing techniques such as micro-nano fabrication. The material of the second electrodes 122 can be gold, platinum, or platinum-iridium, etc.

[0034] In another embodiment, when fabricating the first flexible substrate 110, an array of metal rivet-like structures are formed on the surface of the first flexible substrate 110 using precision processing techniques such as micro-nano fabrication. When fabricating the second flexible substrate 120, an array of grooves (or micropores) matching the array of rivet-like structures and second electrodes 122 surrounding the corresponding grooves are formed on the second flexible substrate 120 using precision processing techniques such as micro-nano fabrication. The material of the second electrodes 122 can be gold, platinum, or platinum-iridium, etc. Then, insulating spacers ins are formed on the surface of each second electrode 122.

[0035] When multiple first joints 111 and corresponding first electrodes 112 are integrally formed on the surface of the first flexible substrate 110 with a metallic material, such as Figure 3BAs shown, the aperture of the plurality of second electrodes 122 is larger than the aperture of the corresponding second junction 121. That is, the inner periphery of each second electrode 122 is not flush with the inner periphery of the corresponding second junction 121 and has a gap. Thus, when the first flexible substrate 110 covers and adheres to the second flexible substrate 120, the first junction 111 is inserted into the corresponding second junction 121, and its outer periphery has the aforementioned gap with the corresponding second electrode 122 so that they do not contact each other. This avoids the first junction 111 made of metal material from contacting the corresponding second electrode 122 and causing a short circuit, thus ensuring the quality of the implanted flexible component 100.

[0036] In another embodiment, the first joint 111 may be a micropillar made of insulating material protruding from the corresponding first electrode 112. Since the first joint 111 will not short-circuit even if it comes into contact with the corresponding second electrode 122 when it is inserted into the corresponding second joint 121, the aperture of the plurality of second electrodes 122 may be greater than or equal to the aperture of the corresponding second joint 121. That is, the inner periphery of each second electrode 122 may be flush with or have a certain distance from the inner periphery of the corresponding second joint 121.

[0037] like Figure 1 As shown, in this embodiment, when the first joint 111 is inserted into the corresponding second joint 121, the end of the first joint 111 away from the corresponding first electrode 112 abuts against the bottom of the corresponding second joint 121. This ensures the insertion depth of the first joint 111 and the second joint 121, thereby ensuring the mechanical fixing effect of the first joint 111 and the second joint 121. At this time, the height of the first joint 111 protruding from the corresponding first electrode 112 (or the first over-electrode thickness) can be the average thickness, minimum thickness, or maximum thickness of the first joint 111 measured from the upper surface of the first electrode 112. In this embodiment, the first over-electrode thickness is equal to the sum of the thickness of the insulating spacer ins, the thickness of the second electrode 122, and the depth of the second joint 121. In actual operation, this is not a limitation, and the height of the first joint 111 protruding from the corresponding first electrode 112 can also be slightly greater than the sum of the thickness of the insulating spacer ins, the thickness of the second electrode 122, and the depth of the second joint 121. The thickness of the first over-electrode can be from 10 to 5000 micrometers, preferably 10 to 100 micrometers. The second joint 121 has a depth that matches that of the first joint 111, which will not be described further.

[0038] In one embodiment, a first flexible substrate 110 covers and adheres to a second flexible substrate 120. Multiple first electrodes 112, multiple insulating spacers, and multiple second electrodes 122 are arranged in an array to form multiple capacitors. In the formed capacitor array, each insulating spacer ins is located between the corresponding first electrode 112 and second electrode 122. As the thickness of the insulating spacer ins changes, the distance between the corresponding first electrode 112 and second electrode 122 can be considered to change, thereby causing a change in the detected value of the corresponding capacitor. Thus, the deformable nature of the multiple insulating spacers ins can be utilized to achieve normal capacitance detection between the electrodes.

[0039] The present invention also proposes a method for manufacturing an implantable flexible component, comprising: forming a plurality of first bonding portions 111, a plurality of first electrodes 112 arranged in an array, and a plurality of first connecting lines 113 on a first flexible substrate 110, wherein the plurality of first connecting lines 113 are connected to the plurality of first electrodes 112 in a one-to-one correspondence, and the plurality of first bonding portions 111 protruding from the plurality of first electrodes 112; and forming a plurality of second bonding portions 121, a plurality of second electrodes 122 arranged in an array, and a plurality of second connecting lines 123 on a second flexible substrate 120, wherein the plurality of second connecting lines 123 are connected to the plurality of second electrodes 122 in a one-to-one correspondence.

[0040] In one embodiment, the aforementioned plurality of insulating spacers ins are disposed one-to-one on the plurality of first electrodes 112, please refer to Figures 4 to 6 , Figure 4 This is a partial cross-sectional schematic diagram of the implantable flexible component of the present invention in a second mode. Figure 5 for Figure 4 A partial cross-sectional view of the implanted flexible component before its second-mode bonding. Figure 6 for Figure 5 A top view of the third flexible substrate. The implantable flexible component 100 also includes a third flexible substrate 130. The third flexible substrate 130 is equipped with an array of third joints 131, third electrodes 132, and third connecting lines 133 corresponding to a plurality of second joints 121, a plurality of second electrodes 122, and a plurality of second connecting lines 123 on the second flexible substrate 120. Each third electrode 132 corresponds one-to-one with a third joint 131, and each third electrode 132 surrounds a corresponding third joint 131. The multiple third connecting lines 133 are connected one-to-one with each third electrode 132, so that when the third flexible substrate 130 is implanted in the body / attached to the surface of a target biological tissue, signal transmission between the multiple third electrodes 132 and an external controller (e.g., a data processing component 200, detailed later) can be achieved via the multiple third connecting lines 133. Each third joint 131 has one of its corresponding second joints 121 as a protrusion and the other as a groove.

[0041] In the second mode, the first flexible substrate 110 is removed from the second flexible substrate 120, and the third flexible substrate 130 covers and adheres to the second flexible substrate 120. A plurality of third junctions 131 correspond one-to-one with a plurality of second junctions 121 and are joined to each other. A plurality of third electrodes 132 correspond one-to-one with a plurality of second electrodes 122 and are in electrical contact with each other. In other words, the plurality of third electrodes 132 and the plurality of second electrodes 122 are fully conductive, thus forming a plurality of resistors (or a resistor array) arranged in an array.

[0042] In this invention, the third flexible substrate 130 is similar to the first flexible substrate 110, and both can be matched and joined with the same second flexible substrate 120. When the joining part on the second flexible substrate 120 is a groove (or micro-hole), the third flexible substrate 130 and the first flexible substrate 110 can be provided with corresponding protrusions (or micro-pillars). By providing multiple third joints 131 and multiple second joints 121 on the third flexible substrate 130 and the second flexible substrate 120, during the process of the third flexible substrate 130 covering and attaching to the second flexible substrate 120, the mutual matching of the multiple third joints 131 and the corresponding second joints 121 can ensure the precise alignment of the third flexible substrate 130 and the second flexible substrate 120. After the third flexible substrate 130 covers and attaches to the second flexible substrate 120, the third flexible substrate 130 and the second flexible substrate 120 can encapsulate multiple third electrodes 132, multiple second electrodes 122, etc., so that when the third flexible substrate 130 and the second flexible substrate 120 are implanted in the body, the electrodes on them can be reduced or even avoided from being contaminated. Each third joint 131 is matched with the same second joint 121 as each first joint 111. Thus, the abnormal region marked in the first mode will not move in the second mode, so targeted excitation can be performed in the second mode (detailed below). Furthermore, the mechanical connection between the multiple third joints 131 and the corresponding second joints 121 helps to reliably fix the third flexible substrate 130 on the second flexible substrate 120, ensuring the accuracy of excitation.

[0043] like Figure 4As shown, in this embodiment, when the third joint 131 is inserted into the corresponding second joint 121, the end of the third joint 131 away from the corresponding third electrode 132 abuts against the bottom of the corresponding second joint 121. This ensures the insertion depth of the third joint 131 and the second joint 121, thereby guaranteeing the mechanical fixing effect of the second joint 131 and the second joint 121. The height of the third joint 131 protruding from the corresponding third electrode 132 (or the second over-electrode thickness) can be the average thickness, minimum thickness, or maximum thickness of the third joint 131 measured from the upper surface of the third electrode 132. In this embodiment, the second over-electrode thickness is equal to the sum of the thickness of the second electrode 122 and the depth of the second joint 121. In actual operation, this is not a limitation; the height of the third joint 131 protruding from the corresponding third electrode 132 can also be slightly greater than the sum of the thickness of the second electrode 122 and the depth of the second joint 121.

[0044] In this embodiment, since no corresponding insulating spacer ins is provided on each of the third electrodes 132 of the third flexible substrate 130, the second over-electrode height of each third joint 131 on the third flexible substrate 130 protruding from the corresponding third electrode 132 is less than the first over-electrode height of each first joint 111 on the first flexible substrate 110 protruding from the corresponding first electrode 112. The difference between the first over-electrode height and the second over-electrode height is, for example, equal to the thickness of the insulating spacer ins, but is not limited thereto.

[0045] In addition, this invention also proposes an implantable flexible biological tissue detection system 1000, please refer to [reference needed]. Figure 7 , Figure 7 This is a schematic diagram of the implantable flexible biological tissue detection system of the present invention. In addition to the aforementioned implantable flexible component 100, the implantable flexible biological tissue detection system 1000 also includes a data processing component 200. The operating modes of the implantable flexible biological tissue detection system 1000 of the present invention may include a detection mode and a stimulation mode. The first mode of the aforementioned implantable flexible component 100 corresponds to the detection mode, and the second mode of the aforementioned implantable flexible component 200 corresponds to the stimulation mode.

[0046] In detection mode, in order to acquire the true signal of the reaction (e.g., the true signal of a human body's reaction), the implantable flexible component 100 (specifically, the first flexible substrate 110 and the second flexible substrate 120) can be placed on the surface of the target biological tissue (e.g., the surface of the target biological tissue inside the human body). The data processing component 200 can be located outside the body. The data processing component 200 is electrically connected to multiple first connecting lines 113 and multiple second connecting lines 123 to transmit electrical signals with the multiple first connecting lines 113 and multiple second connecting lines 123. The weak electrical signal sensed by the implantable flexible component 100 can be transmitted to the external data processing component 200 via wires. In one embodiment, the data processing component 200 may pre-store a first threshold range. The data processing component 200 receives multiple first electrical signals from multiple first connection lines 113 and multiple second connection lines 123, compares the multiple first electrical signals (or the first electrical signals after integration processing) with the first threshold range one by one, and divides (or marks) the areas formed by the first electrode 112 and the second electrode 122 corresponding to the first electrical signals that exceed the first threshold range as abnormal areas.

[0047] Specifically, in the detection mode, the second flexible substrate 120 (specifically, the surface of the second flexible substrate 120 without the second joint 121 and the second electrode 122) can be attached to the surface of the target biological tissue (e.g., an organ). Then, the first flexible substrate 110 is covered and attached to the first flexible substrate 110, and the multiple first joints 111 are inserted and fastened to the corresponding second joints 121 in a one-to-one correspondence, so as to achieve precise positioning and mechanical locking of the first flexible substrate 110 and the second flexible substrate 120. The multiple first electrodes 112, the multiple insulating spacers ins, and the multiple second electrodes 122 correspond one-to-one to form a capacitor array whose top and bottom are wrapped by anti-fouling flexible polymer flexible material (i.e., the first flexible substrate 110 and the second flexible substrate 120). After the implanted flexible component 100 (specifically, multiple first connecting lines 113 on the first flexible substrate 110 and multiple second connecting lines 123 on the second flexible substrate 120) is electrically connected to an external controller (such as a data processing component 200) located outside the body, the data processing component 200 receives the first electrical signals transmitted by the multiple first connecting lines 113 and the multiple second connecting lines 123 to confirm the multiple capacitance detection values ​​corresponding to multiple electrode pairs. The data processing component 200 compares the multiple capacitance detection values ​​with a first threshold range one by one. If a capacitance detection value exceeds the first threshold range, the electrode pair corresponding to this capacitance detection value is considered to be in an abnormal region. This process continues until all capacitance detection values ​​have been compared, and the regions formed by the electrode pairs corresponding to all capacitance detection values ​​exceeding the first threshold range are classified as abnormal regions. In this way, regions with non-physiological abnormal biological signals on the surface of target biological tissues (such as the surface of organs) can be detected and marked on the external controller. The edge accuracy of the marked regions is much higher than ±250um of imaging methods such as magnetic resonance imaging. The aforementioned organs include the microbrain and the heart.

[0048] After identifying the abnormal area, the implantable flexible biological tissue detection system 1000 can be switched to stimulation mode to treat the abnormal area accordingly. Specifically, in stimulation mode, the second flexible substrate 120, which is in contact with the surface of the target biological tissue (e.g., the surface of an organ), remains stationary. The first flexible substrate 110 is removed from the second flexible substrate 120, and a third flexible substrate 130 is placed on top of and attached to the second flexible substrate 120. Multiple third joints 131 correspond one-to-one with multiple second joints 121 and are engaged with each other, achieving precise positioning and mechanical locking of the third flexible substrate 130 and the second flexible substrate 120. Multiple third electrodes 132 correspond one-to-one with multiple second electrodes 122 and are electrically in contact with each other, forming a structure where the top and bottom are wrapped with a non-fouling flexible polymer material (i.e., the second flexible substrate 120 and the third flexible substrate 130). Each second electrode 122 and its corresponding third electrode 132 form their own fully conductive resistor array. The data processing component 200 is then electrically connected to multiple third connecting lines 133 and multiple second connecting lines 123.

[0049] Since the position of the second flexible substrate 120 remains unchanged, the position of the abnormal area marked in the detection mode will not shift in the stimulation mode, meaning that the abnormal area marked in the detection mode can be accurately applied to the stimulation mode. After electrically connecting the implanted flexible component 100 (specifically, multiple second connecting lines 123 on the second flexible substrate 120 and multiple third connecting lines 133 on the third flexible substrate 130) to an external controller (such as a data processing component 200), the data processing component 200 transmits second electrical signals to multiple third electrodes 132 and second electrodes 122 within the abnormal area. The second electrical signals transmitted by the data processing component 200 to each third electrode 132 and second electrode 122 can be different. For example, the data processing component 200 can determine different excitation values ​​corresponding to each third electrode 132 and second electrode 122 within the abnormal area in the stimulation mode based on the capacitance detection values ​​received in the detection mode, and transmit corresponding second electrical signals to the corresponding third electrodes 132 and second electrodes 122 with different excitation values.

[0050] In this embodiment, since each second electrode 122 is fully conductive with its corresponding third electrode 132, the data processing component 200 can electrically excite the second electrode 122 and the third electrode 132 within the abnormal area marked in the detection mode, thereby inducing a thermal effect and enabling corresponding intervention. Because the edge accuracy of the area marked in the detection mode is much higher than ±250µm using imaging techniques such as magnetic resonance imaging, the intervention in normal areas other than the marked abnormal areas is minimal, allowing for precise intervention.

[0051] In this embodiment, the unique anchoring structure, achieved through the arrangement of the first joint 111, the second joint 121, and the third joint 131, ensures the precise positioning and alignment of the two flexible substrates (the first flexible substrate 110 and the second flexible substrate 120, and the third flexible substrate 130 and the second flexible substrate 120). In detection mode, the second flexible substrate 120 is paired with the first flexible substrate 110 (which can be considered as the detection flexible substrate) to mark abnormal areas. In stimulation mode, the second flexible substrate 120 remains unchanged, while the first flexible substrate 110 is removed and replaced with the third flexible substrate 130 (which can be considered as the stimulation flexible substrate). This prevents the marked abnormal areas from moving in detection mode, allowing for precise intervention in these abnormal areas. Furthermore, each flexible substrate is formed of a flexible polymer material with anti-fouling properties, which can encapsulate sensitive electronic components, preventing them from being contaminated and extending their service life.

[0052] like Figure 7 As shown, the implantable flexible biological tissue detection system 1000 also includes a thin-film connection assembly 300, which may include a flexible adapter integrally constructed on a polymer material via thin-film leads, such as a proximal end and a distal end of a thin-film adapter that are interlocked with each other. The proximal end of the thin-film adapter is connected to the data processing assembly 200 via a wire, and the distal end of the thin-film adapter is used to connect to a plurality of first connection lines 113 and a plurality of second connection lines 123 via wires in detection mode, and to a plurality of second connection lines 123 and a plurality of third connection lines 133 via wires in stimulation mode.

[0053] In one embodiment, in detection mode, the thin-film connection assembly 300 includes a first thin-film adapter proximal end 310 and a first thin-film adapter distal end 320 that are mutually connected, and a second thin-film adapter proximal end 330 and a second thin-film adapter distal end 340 that are mutually connected. The first thin-film adapter proximal end 310 is connected to the data processing assembly 140 via a first wire, the first thin-film adapter distal end 320 is connected to a plurality of first connecting lines 113 via a second wire, the second thin-film adapter proximal end 330 is connected to the data processing assembly 140 via a third wire, and the second thin-film adapter distal end 340 is connected to a plurality of second connecting lines 123 via a fourth wire. Since the first and third wires are both located outside the human body and are both connected to the data processing assembly 200, they can be integrated into a single cable before being connected to the data processing assembly 200. In stimulation mode, the process is similar to detection mode, except that the first thin-film adapter proximal end 310 is instead mutually connected to the first thin-film adapter distal end connected to the plurality of third connecting lines 133, which will not be described further.

[0054] In one embodiment, taking the proximal end 310 of the first thin-film adapter as an example, it includes a housing, a substrate, and multiple electrode terminals. A first wire includes multiple mutually insulated connecting wires. The substrate is disposed at the bottom of the housing and may be disc-shaped. Each electrode terminal is vertically fixed to the substrate and is uniformly or non-uniformly distributed. Each connecting wire is connected to each electrode terminal. The top of the housing is an opening for insertion into the distal end 320 of the first thin-film adapter, for example, the distal end 320 of the first thin-film adapter is inserted into the opening of the housing of the proximal end 310 of the first thin-film adapter. The proximal end 330 of the second thin-film adapter is similar to the proximal end 310 of the first thin-film adapter and will not be described further.

[0055] In one embodiment, taking the distal end 320 of the first thin-film adapter as an example, it includes a base plate, a housing, multiple solder pads, an insulating pad, an adhesive layer, and conductive epoxy resin. The base plate is disposed at the bottom of the housing and together form a cavity. The top of the housing is an opening for insertion and connection with the proximal end 320 of the first thin-film adapter. The solder pads, insulating pads, adhesive layer, conductive epoxy resin, and second wires are located within the cavity. The second wires are disposed on the base plate via the adhesive layer and include multiple mutually insulated third connecting lines. Multiple solder pads are fixedly connected to one end of the corresponding third connecting lines. Conductive pins and solder pads form an electrical connection. Conductive epoxy resin is disposed at the bottom of the multiple conductive pins and the bottom of the multiple solder pads to bond each conductive pin to the corresponding solder pad. The base plate may be disc-shaped, and the solder pads may be uniformly or non-uniformly distributed. Insulating pads are disposed between the solder pads to isolate different solder pads and prevent short circuits between different solder pads. One end of each third connecting line is connected to a solder pad, and the other end of each third connecting line is connected to a corresponding plurality of first connecting lines 113, thereby electrically connecting to an electrode of the implantable flexible component 100. The housing may be composed of one or more layers of dielectric material, such as polyimide, liquid crystal polymer, polyxylene, polyetheretherketone, etc. The distal end 340 of the second thin film adapter is similar to the distal end 320 of the first thin film adapter, and will not be described again.

[0056] In this invention, via the thin-film connection assembly 300, the weak electrical signals of the implantable flexible component 100 can be transmitted to the distal end 320 of the first thin-film adapter, the distal end 340 of the second thin-film adapter, and then to the data processing assembly 200 via the proximal end 310 of the first thin-film adapter and the proximal end 330 of the second thin-film adapter. Similarly, the second electrical signals sent by the data processing assembly 200 are transmitted to the proximal end 310 of the first thin-film adapter, the proximal end 330 of the second thin-film adapter, and then to the corresponding electrodes on the implantable flexible component 100 via the distal end 340 of the first thin-film adapter.

[0057] In one embodiment, the third wire can be integrally formed with the first flexible substrate 110. That is, multiple first bottom layers 111 and multiple first electrodes 112 are arrayed on the first part of the flat flexible substrate, and multiple first connecting lines 113 electrically connected to the multiple first electrodes 112 are provided. Multiple third connecting lines are insulated and arranged on the second part of the flat flexible substrate. One end of each third connecting line is used to electrically connect to multiple first pads 321 of the distal end 320 of the first thin film adapter, and the other end of each third connecting line is connected to the corresponding first connecting line 113. The width of the first connecting line 113 and the third connecting line can be less than 0.1 mm. In use, the second wire together with the implantable flexible component 100 can be placed in the body / attached to the surface of the target biological tissue for relevant medical experiments. The weak electrical signals on the implantable flexible component 100 are transmitted to the distal end 320 of the first thin film adapter through the first connecting line 113 and the third connecting line, and then transmitted to the data processing component 200 through the proximal end 310 of the first thin film adapter and the first wire. The fourth wire and the second flexible substrate 120 are similar and will not be described in detail.

[0058] In one embodiment, the multiple pads may be composed of one or more layers of conductive material, which may be gold (Au), platinum (Pt), platinum 30 / iridium (Pt / Ir), titanium (Ti), gold / titanium (Au / Ti), or any alloy thereof. The third connecting line may be composed of one or more layers of conductive material, which may be platinum (Pt), platinum / iridium (Pt / Ir), titanium (Ti), gold / titanium (Au / Ti), or any alloy thereof.

[0059] In this invention, a plurality of first bonding portions and a plurality of second bonding portions are respectively provided on the first flexible substrate and the second flexible substrate. During the process of the first flexible substrate covering and attaching to the second flexible substrate, the mutual matching of the plurality of first bonding portions and the corresponding second bonding portions ensures the precise alignment of the first flexible substrate and the second flexible substrate. After the first flexible substrate covers and attaches to the second flexible substrate, the first flexible substrate and the second flexible substrate can encapsulate the plurality of first electrodes and the plurality of second electrodes therein, so that when the first flexible substrate and the second flexible substrate are implanted in the body, the electrodes on them can be reduced or even avoided from being contaminated, thus extending the overall service life of the implantable flexible component. Furthermore, the mechanical engagement between the plurality of first bonding portions and the corresponding second bonding portions helps to reliably fix the first flexible substrate on the second flexible substrate, ensuring the stability of the implantable flexible component during use and ensuring the accuracy of the test results.

[0060] The present invention has been described by the above-described embodiments; however, these embodiments are merely examples for implementing the present invention. Furthermore, the technical features involved in the different embodiments of the present invention described above can be combined with each other as long as they do not conflict with each other. It must be pointed out that the disclosed embodiments do not limit the scope of the present invention. On the contrary, any modifications and refinements made without departing from the spirit and scope of the present invention are within the scope of patent protection of the present invention.

Claims

1. An implantable flexible component, characterized in that... Include, A first flexible substrate is provided with a plurality of first connecting lines, a plurality of first junctions arranged in an array, and a plurality of first electrodes arranged in an array. The plurality of first electrodes correspond one-to-one with the plurality of first junctions, and each first electrode surrounds a corresponding first junction. The plurality of first connecting lines are connected one-to-one with the plurality of first electrodes. as well as The second flexible substrate is provided with a plurality of second connecting lines, a plurality of second joints arranged in an array, and a plurality of second electrodes arranged in an array. The plurality of second electrodes correspond one-to-one with the plurality of second joints, and each second electrode surrounds the corresponding second joint. The plurality of second connecting lines are connected one-to-one with the plurality of second electrodes. Each first joint is a protrusion and the other is a groove in one of the corresponding second joints. A plurality of insulating spacers are provided one-to-one on the plurality of first electrodes or one-to-one on the plurality of second electrodes. In the first mode, the first flexible substrate covers and adheres to the second flexible substrate, the plurality of first joints correspond one-to-one with the plurality of second joints and are interlocked with each other, and each insulating spacer is located between the corresponding first electrode and the corresponding second electrode. The plurality of first joints are plurality of protrusions, and each first joint protrudes from a corresponding first electrode. The plurality of second joints are plurality of grooves that match the plurality of protrusions. The aperture of the plurality of second electrodes is greater than or equal to the aperture of the corresponding second joint. Alternatively, the plurality of first joints are plurality of grooves disposed on the first flexible substrate. The plurality of second joints are plurality of protrusions that match the plurality of grooves, and each second joint protrudes from a corresponding second electrode. The aperture of the plurality of first electrodes is greater than or equal to the aperture of the corresponding first joint.

2. The implantable flexible component as described in claim 1, characterized in that, When the plurality of first joints are multiple protrusions, the plurality of first electrodes and the corresponding first joints are integrally formed on the first flexible substrate, and the aperture of the plurality of second electrodes is larger than the aperture of the corresponding second joint.

3. The implantable flexible component as described in claim 1, characterized in that, The plurality of insulating spacers are correspondingly disposed on the plurality of first electrodes, and the implantable flexible component further includes... The third flexible substrate is provided with multiple third connecting lines, multiple third joints, and multiple third electrodes arranged in an array, corresponding to the multiple second connecting lines, the multiple second joints, and the multiple second electrodes. The multiple third electrodes correspond one-to-one with the multiple third joints, and each third electrode surrounds the corresponding third joint. The multiple third connecting lines are connected one-to-one with the multiple third electrodes. Each third joint is connected to one of the corresponding second joints, which is a protrusion and the other is a groove. In the second mode, the first flexible substrate is removed from the second flexible substrate, the third flexible substrate covers and adheres to the second flexible substrate, and the plurality of third joints correspond one-to-one with the plurality of second joints and are joined to each other, and the plurality of third electrodes correspond one-to-one with the plurality of second electrodes and are in electrical contact with each other.

4. An implantable flexible biological tissue detection system, characterized in that... Include, The implantable flexible component as described in any one of claims 1 to 2; and In the first mode, the data processing component is electrically connected to the plurality of first connection lines and the plurality of second connection lines to transmit electrical signals with the plurality of first connection lines and the plurality of second connection lines.

5. The implantable flexible biological tissue detection system as described in claim 4, characterized in that, The data processing component pre-stores a first threshold range. The data processing component is used to receive multiple first electrical signals from the multiple first connection lines and the multiple second connection lines, compare the multiple first electrical signals with the first threshold range one by one, and classify the area formed by the first electrode and the second electrode corresponding to the first electrical signal that exceeds the first threshold range as an abnormal area.

6. The implantable flexible biological tissue detection system as described in claim 5, characterized in that, The plurality of insulating spacers are disposed one-to-one on the plurality of first electrodes. The implantable flexible component further includes a third flexible substrate. The third flexible substrate is provided with a plurality of third connecting lines, a plurality of third joints arranged in an array, and a plurality of third electrodes arranged in an array, corresponding to the plurality of second connecting lines, the plurality of second joints, and the plurality of second electrodes. The plurality of third electrodes correspond one-to-one with the plurality of third joints, and each third electrode surrounds a corresponding third joint. The plurality of third connecting lines are connected one-to-one with the plurality of third electrodes. In the second mode, the first flexible substrate is removed from the second flexible substrate, and the third flexible substrate covers and adheres to the second flexible substrate. The plurality of third joints correspond one-to-one with the plurality of second joints and are engaged with each other. The plurality of third electrodes correspond one-to-one with the plurality of second electrodes and are electrically in contact with each other. In the second mode, the data processing component is electrically connected to the plurality of second connecting lines and the plurality of third connecting lines to transmit at least one second electrical signal to the third electrode and the second electrode in the abnormal region.

7. The implantable flexible biological tissue detection system as described in claim 6, characterized in that... It also includes a thin-film connection assembly, which includes a near end and a far end of a thin-film adapter that are interlocked with each other. The near end of the thin-film adapter is connected to the data processing component via a wire. The far end of the thin-film adapter is connected to the plurality of first connection lines and the plurality of second connection lines via a wire in the first mode, and to the plurality of third connection lines and the plurality of second connection lines via a wire in the second mode.

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