Sterile packaging material and method for automated production using sterile packaging material

Abstract

The present application relates to sterile packaging material and a method for automated production using the sterile packaging material, and belongs to the field of medicine packaging. The present application aims to solve the problem that the existing sterile packaging material cannot efficiently transmit and dock the sterile bottle body and the sterile rubber plug. The sterile packaging material comprises a bottle body, a rubber plug, an aluminum cover, a nest plate and a pressing cover. The bottle body, the rubber plug and the aluminum cover are fixed by the nest plate and the pressing cover. The rubber plug and the aluminum cover are on the bottle body most of the time and only leave the bottle body during medicine sub-packaging, so they do not occupy extra space and facilitate automated operation in limited space. The relative position between the rubber plug, the aluminum cover and the bottle body is determined, so that the rubber plug and the aluminum cover are not randomly distributed. The automated production is completely realized, the process of manually placing the rubber plug and the aluminum cover on the bottle body before the hot chamber production is avoided, the process is reduced, and the production time is saved. Due to the particularity of radioactive medicine, the activity utilization rate of the nuclide is improved, the production cost is saved, manual participation is avoided, and the risk of destroying the sterile environment of the bottle body is reduced.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical packaging, specifically aseptic packaging materials and methods for automated production using aseptic packaging materials. Background Technology

[0002] Sterile packaging materials are required in the production of radiopharmaceuticals. Traditional sterile packaging materials include a bottle body, rubber stopper, and aluminum cap. The bottle body is used to dispense the drug. After the drug is dispensed into the bottle body, the rubber stopper is inserted, and then the aluminum cap is attached to seal the drug. Before dispensing, the bottle body and rubber stopper are completely separate. Multiple bottles are usually bundled together with plastic, while multiple rubber stoppers are packaged individually. Due to the limited space in the production shielded heat chamber, a complete washing, drying, and filling line cannot be formed. Currently, sterile products and sterile rubber stoppers and aluminum caps are often manually loaded and connected in batches. This not only occupies the limited operating space in the heat chamber but also increases the drug production time. The nuclides in radiopharmaceuticals decay and decrease over time. In other words, the longer the production time, the less usable active pharmaceutical ingredient remains, and the higher the risk of contamination.

[0003] With the advancement of technology, the production process of radiopharmaceuticals is becoming increasingly automated. However, this also brings the challenge of achieving complex automation within limited spaces. One common automated operation is the use of robots to dispense drugs in high-level clean environments. Currently, when dispensing drugs using aseptic packaging materials, robotic arms pick up the vials for dispensing, while the rubber stoppers are manually placed in another location after being removed. The robotic arms then pick up the stoppers from that location for reinstallation. This process requires a large production space and cannot achieve efficient and aseptic connection between the aseptic vials and the aseptic rubber stoppers / aluminum caps. Summary of the Invention

[0004] The purpose of this invention is to provide a sterile packaging material that solves the problem that existing sterile packaging materials cannot efficiently transfer and connect sterile bottles and sterile rubber stoppers, thereby improving production efficiency.

[0005] The technical solution adopted in this invention is: aseptic packaging material, including bottle body and rubber stopper, and also including nest plate and cap;

[0006] Multiple rows of receiving holes are evenly arranged longitudinally on the nest plate, with N receiving holes of equal size in each row, and the N receiving holes in each row are evenly distributed transversely.

[0007] The bottle body is composed of two sections along its axial direction: the bottom section where the bottle bottom is located and the top section where the bottle neck and bottle mouth are located.

[0008] The receiving hole is adapted to the bottle body; the bottom section of the bottle body is inserted into the receiving hole, and the top section is exposed outside the receiving hole; the rubber stopper is freely inserted into the bottle mouth;

[0009] The pressure cap is placed on top of the rubber stopper and is detachably connected to the groove plate; and a limiting structure is provided to restrict the movement of the nest plate and the pressure cap along a vertical linear trajectory.

[0010] Furthermore, the limiting structure includes a first positioning pin hole provided around the nest plate, a second positioning pin hole corresponding to the first positioning pin hole around the pressure cap, and a positioning pin inserted into the first positioning pin hole and the second positioning pin hole.

[0011] Furthermore, the first positioning pin hole is a blind hole with its bottom closed, and the top end of the positioning pin is fixed in the second positioning pin hole, while the bottom end is movably inserted into the first positioning pin hole.

[0012] Furthermore, the bottom end of the positioning pin is inserted into the second positioning pin hole, and the top end is movably inserted into the second positioning pin hole.

[0013] Furthermore, along the longitudinal direction, buckles are provided at both ends of the cap, and the buckles are detachably snapped onto both ends of the nest plate.

[0014] Furthermore, a notch is provided in the middle of both ends of the nest plate, which is concave inward along the longitudinal direction.

[0015] The middle part of both ends of the pressure cap is provided with a bending part that bends downward vertically. Two concave notches are provided at both ends of the pressure cap, and the two notches are symmetrical about the bending part.

[0016] The buckle includes a U-shaped body, a pivot, and a spring. The U-shaped body is installed on the bent part of the pressure cap via the pivot and the spring. The top of the U-shaped body is provided with a manual part, and the bottom is provided with a hook. The hook is located in the second recess of the nest board and is hooked to the nest board.

[0017] Furthermore, the buckle is an elastic buckle.

[0018] Furthermore, it includes a flat plate portion and flanges that fold downwards from both sides of the flat plate portion in the transverse direction.

[0019] Furthermore, the nest plate includes a bottom plate at the bottom and a top plate above the bottom plate, with a distance between the bottom plate and the top plate;

[0020] The receiving hole includes a circular limiting hole that penetrates the top plate and is adapted to the bottle body, with the bottom plate serving as the bottom of the receiving hole.

[0021] Furthermore, a weight-reducing hole is provided on the bottom plate at the position corresponding to the through hole in the top plate, and the inner diameter of the weight-reducing hole is smaller than the diameter of the limiting hole.

[0022] Furthermore, recessed pin slots are provided at the four corners of the nest plate to match the positioning pins on the worktable.

[0023] Furthermore, it also includes nest boxes used to cover nest boards, caps, and bottles.

[0024] A method for automated production using aseptic packaging materials includes the following steps:

[0025] Step 1: Take out the nesting board and cap containing the bottle, align the pin groove of the nesting board with the positioning pin on the worktable, and place the nesting board and cap together on the worktable from top to bottom.

[0026] Step 2: Remove the pressure cap vertically;

[0027] Step 3: The filling machine picks up the bottle with the rubber stopper and places it onto the filling table;

[0028] Step 4: The robotic arm of the filling machine vertically sucks the rubber stopper away from the bottle opening;

[0029] Step 5: Fill the bottle with the medicine;

[0030] Step Six: The robotic arm of the filling machine inserts the rubber stopper back into the bottle opening.

[0031] Step 7: Roll an aluminum cap onto the bottle neck.

[0032] The beneficial effects of this invention are as follows: The aseptic packaging material disclosed in this invention fixes the bottle body, rubber stopper, and aluminum cap by means of a nest plate and a capping mechanism. The structure is simple, and the bottle body corresponds one-to-one with the rubber stopper and aluminum cap, eliminating the need for separate placement of the bottle body, rubber stopper, and aluminum cap. It also has the following advantages:

[0033] Firstly, the rubber stopper and aluminum cap are on the bottle most of the time, and only leave the bottle during drug dispensing. They do not take up extra space, which helps to save sterile isolation space and facilitates automated operation in a limited space.

[0034] Secondly, the rubber stopper is grasped from the bottle body and then reinstalled. The bottle body positions the rubber stopper, which helps the robotic arm to accurately grasp the rubber stopper, further improving the efficiency and accuracy of dispensing.

[0035] Thirdly, the precise relative positions of the rubber stopper and aluminum cap to the bottle body prevent disordered distribution of the rubber stopper and aluminum cap, enabling full automation and eliminating the need for manual placement of the rubber stopper and aluminum cap onto the bottle body before hot chamber production. This reduces the number of steps and saves production time. Due to the special nature of radiopharmaceuticals, this improves the utilization rate of radionuclide activity and saves production costs. At the same time, it eliminates the need for manual intervention, reducing the risk of damaging the sterile environment of the bottle and ensuring the cleanliness of the production environment.

[0036] Fourth, because the nested plates arrange the bottles in rows and columns, during production, the bottles can be picked up in rows by robotic arms for mass production, which further improves production efficiency.

[0037] Fifth, it avoids the loss of rubber stoppers or aluminum caps, which helps save costs.

[0038] When using this aseptic packaging material for drug repackaging, the level of automation is improved, production efficiency is increased, and the degree of sterility is guaranteed. Attached Figure Description

[0039] Figure 1 This is a schematic diagram of the structure of the present invention;

[0040] Figure 2 Top view of the nesting board;

[0041] Figure 3 This is a partial cross-sectional view of the present invention.

[0042] In the diagram, the components are: bottle body 1, bottom section 1A, top section 1B, rubber stopper 2, nest plate 3, bottom plate 3A, weight reduction hole 3A1, top plate 3B, through hole 3B1, positioning pin hole 1 3C, notch 1 3D, pin groove 3E, pressure cap 4, flat plate 4A, flange 4B, positioning pin hole 2 4C, notch 2 4D, bent part 4E, positioning pin 5, buckle 6, U-shaped body 6A, rotating shaft 6B, spring 6C, manual part 6D, hook 6E, nest box 7, positioning pin post 8, aluminum cap 9. Detailed Implementation

[0043] The present invention will be further described below with reference to the accompanying drawings and embodiments:

[0044] Traditional aseptic packaging materials consist of a bottle body 1 and rubber stoppers 2. Bottle body 1 is used for dispensing medications. After the medication is dispensed into bottle body 1, the rubber stopper 2 is inserted, and then an aluminum cap is applied to seal the medication. Before dispensing, bottle body 1 and rubber stoppers 2 are completely separate. Multiple bottles body 1 are usually bundled together with plastic, while multiple rubber stoppers 2 are individually packaged. During dispensing, the packaging of bottle body 1 is removed, and each bottle body 1 is manually fitted with a rubber stopper 2 on a workbench. Then, a robotic arm picks up the bottle body 1 with rubber stoppers 2 for dispensing. Throughout this process, manually placing the rubber stoppers 2 not only affects work efficiency but also risks compromising the aseptic environment of bottle body 1, increasing the risk of bacterial contamination.

[0045] The aseptic packaging material disclosed in this invention, like traditional aseptic packaging materials, also includes a bottle body 1, a rubber stopper 2, and an aluminum cap 9. The difference is that, as... Figure 1 , Figure 2 and Figure 3 As shown, it also includes a nesting plate 3 and a capping plate 4;

[0046] Multiple rows of receiving holes are arranged longitudinally on the nest plate 3. Each row has N receiving holes of equal size. The N receiving holes in each row are evenly distributed in the transverse direction, that is, the receiving holes in each row are the same size and the spacing between two adjacent receiving holes is equal.

[0047] The bottle body 1 is composed of two sections along its axial direction: a bottom section 1A where the bottle bottom is located and a top section 1B where the bottle neck and bottle mouth are located.

[0048] The receiving hole is adapted to the bottle body 1; the bottom section 1A of the bottle body 1 is inserted into the receiving hole, and the top section 1B is exposed outside the receiving hole. It should be noted that the receiving hole is adapted to the bottle body 1, which means that the bottom section 1A of the bottle body 1 is inserted into the receiving hole. Therefore, the diameter of the receiving hole needs to correspond to the diameter of the bottle body 1 to ensure that the bottle body 1 can be installed in the receiving hole. At the same time, it should minimize the radial movement of the bottle body 1 in the receiving hole, so that the receiving hole can limit the bottle body 1. At the same time, the receiving hole needs to support the bottom of the bottle body 1 to prevent the bottle body 1 from falling. In this way, the bottom section 1A of the bottle body 1 is inserted into the receiving hole, and the receiving hole limits the bottle body 1, ensuring that the central axis of the bottle body 1 coincides with the central axis of the receiving hole, so as to ensure that the position of all bottles 1 in the receiving hole meets the requirements of mechanical gripping accuracy. Of course, the deeper the bottle body 1 is inserted into the receiving hole, the better it is to avoid problems such as the bottle body 1 tipping over, and the better the limiting effect. However, the clamping path is longer when clamping the bottle body 1. In order to take into account both the limiting and the picking and placing requirements, the depth of the bottle body 1 inserted into the receiving hole is 1 / 3 of the bottle body 1, that is, the height dimension of the bottom section 1A of the bottle body 1 is 1 / 3 of the height of the bottle body 1, and the depth of the receiving hole is equal to the height of the bottom section 1A of the bottle body 1.

[0049] The rubber stopper 2 is freely inserted into the mouth of the bottle body 1, that is, the rubber stopper 2 is not crimped between the bottle body 1 and the bottle body 1, and the rubber stopper 2 can be removed from the bottle body 1.

[0050] The aluminum cap 9 is freely placed on the bottle mouth of the bottle body 1, that is, the aluminum cap 9 is only placed on the bottle mouth of the bottle body 1, the aluminum cap 9 is not rolled on the bottle mouth, and the aluminum cap 9 can be removed from the bottle body 1.

[0051] The cap 4 is placed on top of the aluminum cap 9 and is detachably connected to the slot plate 3. Thus, the cap 4 and the slot plate 3 secure the bottle body 1 and the rubber stopper 2 (i.e., the aluminum cap 9), preventing the rubber stopper 2 and the aluminum cap 9 from separating from the bottle body 1 before use. A limiting structure is provided to restrict the movement of the slot plate 3 and the cap 4 along a vertical linear trajectory. This limiting structure ensures that when the cap 4 is removed or placed, it can only detach from the aluminum cap 9 vertically upwards or contact the aluminum cap 9 vertically downwards. This prevents horizontal displacement when the cap 4 is in contact with the aluminum cap 9, which could cause the rubber stopper 2 or the aluminum cap 9 to detach from the bottle body 1 or the rubber stopper 2 to tilt, thus affecting the smooth operation of subsequent filling processes such as removing the rubber stopper 2, inserting the rubber stopper 2, removing the aluminum cap 9, or putting on the aluminum cap 9. The cap 4 is made of sheet material, which is a rigid material compared to plastic. With the assistance of the limiting structure, when the cap 4 is taken out or put in, the cap 4 moves vertically away from the rubber stopper 2 and the aluminum cap 9, and will not drag the rubber stopper 2 and the aluminum cap 9. This can prevent the rubber stopper 2 and the aluminum cap 9 from tilting or falling off the bottle body 1, thus creating conditions for the robot to grab the rubber stopper 2 during subsequent automatic production.

[0052] The limiting structure can be a slot or plug, etc. In this embodiment, the limiting structure includes a first positioning pin hole 3C provided around the perimeter of the nest plate 3, a second positioning pin hole 4C corresponding to the first positioning pin hole 3C around the perimeter of the pressure cover 4, and a positioning pin 5 inserted into the first positioning pin hole 3C and the second positioning pin hole 4C. The limiting is achieved by the positioning pin 5, which is simple in structure and easy to use.

[0053] Since the bottom surface of the cap 4 directly contacts the aluminum cap 9 and limits its movement, the distance between the bottom surface of the cap 4 and the top surface of the nest plate 3 needs to be adapted to the height of the top section 1B of the bottle body 1 plus the height of the rubber stopper 2 and the aluminum cap 9 protruding from the bottle opening. Therefore, the positioning pin 5, in addition to limiting the linear running trajectory, also participates in limiting the distance between the bottom surface of the cap 4 and the top surface of the nest plate 3.

[0054] In one implementation, the positioning pin hole 3C is a blind hole with a closed bottom. The top of the positioning pin 5 is fixed inside the positioning pin hole 4C. That is, the positioning pin 5 cannot be pulled out from the positioning pin hole 4C before the fixing structure between the positioning pin 5 and the positioning pin hole 4C is released. The fixing structure can be a weld, interference fit, or threaded fit between the positioning pin 5 and the positioning pin hole 4C. The bottom end is movably inserted into the positioning pin hole 3C, meaning that the positioning pin 5 can be pulled out from the positioning pin hole 3C. In this way, the bottom wall of the positioning pin hole 3C limits the bottom end of the positioning pin 5. When the cover is opened, the positioning pin 5 and the pressure cap 4 move vertically upwards until they detach from the aluminum cover 9. In this way, since the positioning pin 5 is fixed to the pressure cap 4, the pressure cap 2 will not drag the aluminum cover 9 when it is removed. However, it is necessary to avoid the positioning pin 5 interfering with the aluminum cover 9 or the rubber stopper 2 after it leaves the positioning pin hole 3C.

[0055] As another implementation, the bottom end of the positioning pin 5 can be fixed to the positioning pin hole 3C, and the top end can be movably inserted into the positioning pin hole 4C. In this way, the positioning pin 5 can effectively avoid interfering with the rubber stopper 2 and the aluminum cap 9. However, due to the obstruction of the positioning pins 5 set around the nest plate 3, it is not convenient for the robot arm to pick up the bottle 1 from the nest plate 3.

[0056] In a third embodiment, the bottom end of the positioning pin 5 is movably inserted into the second positioning pin hole 4C, and the top end is also movably inserted into the second positioning pin hole 4C. With this structure, when removing the pin, the pressure cap 4 can be removed from the positioning pin 5 first, and then the positioning pin 5 can be removed from the nest plate 3. Without the pressure cap 4 interfering with the view, the operator can easily remove the positioning pin 5 without interfering with the rubber stopper 2 and the aluminum cap 9.

[0057] In order to further lock the cap 4 and the nest plate 3 and reduce the probability of relative shaking between them, buckles 6 are provided at both ends of the cap 4 along the longitudinal direction. The buckles 6 are detachably snapped onto both ends of the nest plate 3.

[0058] Specifically, a recessed notch 3D is provided in the middle of both ends of the nest plate 3, which is concave inward along the longitudinal direction;

[0059] The middle part of both ends of the pressure cap 4 is provided with a bending part 4E that bends vertically downwards. Two concave notches 4D are provided at both ends of the pressure cap 4. The two notches 4D are symmetrical about the bending part 4E.

[0060] The buckle 6 includes a U-shaped body 6A, a rotating shaft 6B, and a spring 6C. The U-shaped body 6A is installed on the bent part 4E of the pressure cover 4 via the rotating shaft and the spring 6C. The top of the U-shaped body 6A is provided with a manual part 6D, and the bottom is provided with a hook 6E. The hook 6E is located in the recess 4D of the nest plate 3 and is hooked to the nest plate 3.

[0061] The buckle 6 can also be an elastic buckle.

[0062] The cap 4 can be made of a flat plate. To further improve the limiting performance of the bottle 1 and prevent the bottle from tipping over and coming off between the cap 4 and the nest plate 3 in case of an accident, the cap 4 is groove-shaped, including a flat plate portion 4A and flanges 4B that fold downwards from both sides of the flat plate portion 4A in the transverse direction. The flanges 4B provide a certain degree of obstruction to the bottle 1 in case of an accident.

[0063] Nest board 3 can have various structural forms. For example, nest board 3 can be a single piece of board with blind holes that are open at the top and closed at the bottom. However, if the blind holes are drilled by machining, the overall board will be thicker, resulting in a heavy nest board 3. If the bottom of the blind hole is a structure that protrudes from the board surface, it can be cast using molds, which is inconvenient to manufacture. Furthermore, if the wall of the blind hole deforms, it will be unsuitable for use.

[0064] In this embodiment, the nest plate 3 includes a bottom plate 3A located at the bottom and a top plate 3B located above the bottom plate 3A. The bottom plate 3A and the top plate 3B are spaced apart by a distance, which depends on the height of the bottle body 1. The receiving hole includes a circular limiting hole 3B1 that penetrates the top plate 3B and is adapted to the bottle body 1, with the bottom plate 3A serving as the bottom of the receiving hole.

[0065] The nest plate 3 of this structure is simple and easy to process and manufacture. It is only necessary to ensure that the bottom plate 3A and the top plate 3B have sufficient strength to ensure that the receiving hole does not deform.

[0066] To further reduce the weight of the nest plate 3, a weight-reducing hole 3A1 is provided on the bottom plate 3A at the position corresponding to the through hole 3B1 of the top plate 3B, and the inner diameter of the weight-reducing hole 3A1 is smaller than the diameter of the limiting hole 3B1.

[0067] In order to facilitate fixing the nest plate 3 to the worktable and to facilitate the positioning and gripping of the bottle 1 by the robot arm, concave pin slots 3E are provided at the four corners of the nest plate 3 to match the positioning pins 8 on the worktable.

[0068] For ease of transport, a nest box 7 is also included for covering the nest board 3, the cap 4, and the bottle body 1.

[0069] A method for automated production using aseptic packaging materials includes the following steps:

[0070] Step 1: Take out the nest plate 3 and the cap 4 containing the bottle 1, align the pin groove 3E of the nest plate 3 with the positioning pin 8 on the worktable, and place the nest plate 3 and the cap 4 together on the worktable from top to bottom.

[0071] Step 2: Remove the cap 4 vertically;

[0072] Step 3: The filling machine picks up the bottle 1 with the rubber stopper 2 and aluminum cap 9 and places it on the filling table;

[0073] Step 4: The first robotic arm of the filling machine vertically clamps the aluminum cap 9 away from the bottle mouth of the bottle body 1; then, the second robotic arm of the filling machine vertically sucks the rubber stopper 2 away from the bottle mouth of the bottle body 1.

[0074] Step 5: Fill the bottle with the medicine;

[0075] Step 6: The robotic arm 2 of the filling machine inserts the rubber stopper 2 back into the bottle mouth of the bottle body 1; then the robotic arm 1 puts the aluminum cap 9 back onto the bottle mouth of the bottle body 1.

[0076] Step 7: Roll an aluminum cap onto the bottle neck of bottle 1.

[0077] Compared with traditional production methods, this automated production method integrates the bottle body 1, rubber stopper 2, and aluminum cap 9 into one unit during aseptic packaging material production, and has the following advantages:

[0078] Firstly, it avoids the loss of the rubber stopper 2 or aluminum cap 9, which helps save costs;

[0079] Secondly, the rubber stopper 2 and aluminum cap 9 are on the bottle body 1 most of the time, and only leave the bottle body 1 during the dispensing of medicines. They do not occupy extra space, which helps to save sterile isolation space and facilitates automated operation in a limited space.

[0080] Third, the rubber stopper 2 and aluminum cap 9 are removed from the bottle body 1 and then reinstalled on the bottle body 1. The bottle body 1 is used to position the rubber stopper 2 and aluminum cap 9, which helps the robotic arm to accurately grasp the rubber stopper 2 and aluminum cap 9, further improving the dispensing efficiency and accuracy.

[0081] Fourthly, the relative positions of the rubber stopper 2 and aluminum cap 9 with the bottle body 1 are determined, avoiding disorderly distribution of the rubber stopper 2 and aluminum cap 9. This enables full automation, eliminating the need for manual placement of the rubber stopper 2 and aluminum cap 9 onto the bottle body 1 before hot chamber production. This reduces the number of processes and saves production time. At the same time, it avoids manual intervention, reducing the risk of damaging the sterile environment of the bottle body 1 and ensuring the cleanliness of the production environment.

[0082] Fifth, since the nest plate 3 arranges the bottle body 1 in rows and columns, during production, the bottle body 1 can be picked up in rows by a robotic arm for mass production, which further improves production efficiency.

Claims

1. A method for automated production using aseptic packaging materials, characterized in that: The aseptic packaging material includes a bottle body (1), a rubber stopper (2), an aluminum cap (9), a nest plate (3), and a pressure cap (4); Multiple rows of receiving holes are evenly arranged on the nest plate (3) along the longitudinal direction. Each row has N receiving holes of equal size, and the N receiving holes in each row are evenly distributed along the transverse direction. The bottle body (1) is composed of two sections along its axial direction: a bottom section (1A) where the bottle bottom is located and a top section (1B) where the bottle neck and bottle mouth are located. The receiving hole is adapted to the bottle body (1); the bottom section (1A) of the bottle body (1) is inserted into the receiving hole, and the top section (1B) is exposed outside the receiving hole; the rubber stopper (2) is freely inserted into the bottle mouth of the bottle body (1); the aluminum cap (9) is freely covered on the bottle mouth of the bottle body (1); The pressure cap (4) covers the top of the aluminum cap (9), and the pressure cap (4) is detachably connected to the slot plate (3); and a limiting structure is provided to limit the movement of the nest plate (3) and the pressure cap (4) in a straight vertical trajectory; and concave pin slots (3E) are provided at the four corners of the nest plate (3) to match the positioning pins (8) on the worktable. Includes the following steps: Step 1: Take out the nest board (3) and the cap (4) containing the bottle (1), align the pin slot (3E) of the nest board (3) with the positioning pin (8) on the worktable, and place the nest board (3) and the cap (4) together on the worktable from top to bottom; Step 2: Remove the cap vertically (4); Step 3: The filling machine picks up the bottle (1) with the rubber stopper (2) and aluminum cap (9) and places it on the filling table; Step 4: The first robotic arm of the filling machine vertically clamps the aluminum cap (9) away from the bottle mouth of the bottle body (1); then, the second robotic arm vertically sucks the rubber stopper (2) away from the bottle mouth of the bottle body (1); Step 5: Fill the bottle (1) with the medicine; Step 6: The second robotic arm of the filling machine inserts the rubber stopper (2) back into the bottle mouth of the bottle body (1); then the first robotic arm puts the aluminum cap (9) back into the bottle mouth of the bottle body (1); Step 7: Roll aluminum cap (9) onto the bottle mouth of the bottle body (1).

2. The method for automated production using aseptic packaging materials as described in claim 1, characterized in that: The limiting structure includes a positioning pin hole 1 (3C) provided around the nest plate (3), a positioning pin hole 2 (4C) corresponding to the positioning pin hole 1 (3C) around the pressure cap (4), and a positioning pin (5) inserted into the positioning pin hole 1 (3C) and the positioning pin hole 2 (4C).

3. The method for automated production using aseptic packaging materials as described in claim 2, characterized in that: The first positioning pin hole (3C) is a blind hole with the bottom closed. The top of the positioning pin (5) is fixed in the second positioning pin hole (4C), and the bottom is movably inserted into the first positioning pin hole (3C).

4. The method for automated production using aseptic packaging materials as described in claim 2, characterized in that: The bottom end of the positioning pin (5) is inserted into the second positioning pin hole (4C), and the top end is movably inserted into the second positioning pin hole (4C).

5. The method for automated production using aseptic packaging materials as described in any one of claims 1-4, characterized in that: Along the longitudinal direction, buckles (6) are provided at both ends of the pressure cap (4), and the buckles (6) are detachably snapped onto both ends of the nest plate (3).

6. The method for automated production using aseptic packaging materials as described in claim 5, characterized in that: A recessed notch (3D) is provided at the middle of both ends of the nest plate (3). At the middle of both ends of the pressure cap (4), there are bending portions (4E) that bend vertically downwards. At both ends of the pressure cap (4), there are two recessed notches (4D) that are symmetrical about the bending portions (4E). The buckle (6) includes a U-shaped body (6A), a pivot (6B) and a spring (6C). The U-shaped body (6A) is installed on the bent part (4E) of the pressure cover (4) via the pivot and the spring (6C). The top of the U-shaped body (6A) is provided with a manual part (6D) and the bottom is provided with a hook (6E). The hook (6E) is located in the second notch (4D) of the nest board (3) and is hooked to the nest board (3).

7. The method for automated production using aseptic packaging materials as described in any one of claims 1-4, characterized in that: The nest plate (3) includes a bottom plate (3A) at the bottom and a top plate (3B) above the bottom plate (3A), with a distance between the bottom plate (3A) and the top plate (3B); The receiving hole includes a circular limiting hole (3B1) that penetrates the top plate (3B) and is adapted to the bottle body (1), with the bottom plate (3A) serving as the bottom of the receiving hole.

8. The method for automated production using aseptic packaging materials as described in any one of claims 1-4, characterized in that: It also includes a nest box (7) for covering the nest board (3), the cap (4) and the bottle (1).

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