A herbicidal composition comprising sethoxydim and ethoxyfuroxim and its application

Abstract

The present invention discloses a herbicide composition comprising sethoxydim and ethoxydim and its application, belonging to the technical field of pesticides. The herbicide composition of the present invention comprises sethoxydim and ethoxydim as active ingredients; the mass ratio of sethoxydim to ethoxydim is 1:3 to 1:13. The herbicide composition of the present invention is highly safe for quinoa and does not cause phytotoxicity. The combination of sethoxydim and ethoxydim exhibits a significant synergistic effect, and the herbicide combination has a significant combined synergistic effect on common weeds in quinoa fields. The combination expands the weed control spectrum and has excellent control effects on common weeds in quinoa fields.

Description

Technical Field

[0001] The present invention relates to the technical field of pesticides, and in particular to a herbicidal composition comprising sethoxydim and ethoxyfuroxim and an application thereof. Background Art

[0002] Quinoa has a protein content of 16% to 22%, comparable in quality to powdered milk and meat. It is also rich in various amino acids, including the nine essential amino acids for the human body, in appropriate proportions and easily absorbed. It is also rich in minerals, vitamins, dietary fiber, special chemical components, and bioactive substances. Consequently, it has been dubbed "nutritional gold," "super grain," "food of the future," and "king of vegetarians." Currently, global research on quinoa is limited to variety breeding, while research on weed control technologies in quinoa fields is quite lacking. Chemical weed control is the most economical and effective means of weed control in farmland, but most registered herbicides are highly susceptible to phytotoxicity, resulting in reduced yield and quality, thus hindering the industrialization and large-scale development of quinoa. Therefore, research on chemical weed control in quinoa fields is urgent. The development of a herbicide that is safe, reliable, effective, cost-effective, and easily disseminated for use is a pressing issue in quinoa cultivation.

[0003] Sethoxydim, commonly known as 2-[1-(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-3-hydroxycyclohex-2-enone, belongs to the cyclohexenone class of herbicides and is a highly selective, systemic, foliar treatment. Its mechanism of action is to inhibit acetyl-CoA carboxylase (ACCase) in plants, hindering fatty acid biosynthesis. This inhibits cell division, disrupting normal weed growth and causing weed death. It has a strong killing effect on grass weeds and is safe for dicotyledonous crops. It is currently primarily used to control annual and perennial grass weeds in fields of sethoxydim-resistant millet, soybeans, peanuts, cotton, and flax. It controls grass weeds such as barnyard grass, foxtail grass, crabgrass, wild oats, wild millet, foxtail grass, and goosegrass. It is ineffective against broadleaf weeds. Currently, no studies have been reported on the effect of sethoxydim on weed control in quinoa fields.

[0004] Ethofumesate, commonly known as 2-ethoxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulfonate, belongs to the benzofuran methanesulfonate class of herbicides and is a highly active soil and foliage treatment agent. Its mechanism of action is to inhibit the biosynthesis of very-long-chain fatty acid elongase (VLCFAE) in plants, triggering the production of fatty acid precursors. This can inhibit early seedling growth, damage meristems and coleoptiles, and disrupt normal weed growth, leading to weed death. It is currently primarily used to control annual broadleaf weeds and some grass weeds. It can be used in sugar beets, lawns, golf courses, and other areas to control broadleaf weeds such as quinoa, Amaranthus retroflexus, Solanum nigrum, Chickweed, and Purslane, as well as some grass weeds such as Poa annua. However, no studies have been reported on the use of ethofumesate for weed control in quinoa fields.

[0005] There are currently no reports on a herbicide composition comprising sethoxydim and ethoxyfuroxim, and even fewer reports on the application of sethoxydim and ethoxyfuroxim in quinoa fields for weeding. Summary of the Invention

[0006] The present invention provides a herbicidal composition comprising sethoxydim and ethoxyfuroxim and an application thereof. The herbicidal composition of the present invention realizes safe and efficient weed control in quinoa fields after emergence.

[0007] The present invention first provides a herbicide composition, the active ingredients of which are sethoxydim and ethoxyfuroxim.

[0008] In the above-mentioned herbicidal composition, the mass ratio of sethoxydim to ethopoxatate is 1:3 to 1:13.

[0009] The mass ratio of sethoxydim to ethopoxatin can specifically be 1:3 to 1:10; more specifically, it can be 1:3, 1:4, 1:4.5, 1:5, 1:6, 1:7, 1:7.5, 1:8, 1:9 or 1:10.

[0010] The above-mentioned herbicidal composition is used for weeding quinoa fields;

[0011] Specifically, the weeds in the quinoa field are at least one of purslane, polygonum sylvestris, wild millet and wild oats.

[0012] Second, the present invention provides a herbicide for weeding quinoa fields, wherein the active ingredient of the herbicide is the above-mentioned herbicidal composition.

[0013] The above-mentioned herbicides can be in the form of microemulsions or emulsifiable concentrates.

[0014] In the above-mentioned herbicide, the mass of the herbicidal composition accounts for 10% to 50% of the total mass of the herbicide.

[0015] Among the above-mentioned herbicides, when the herbicide is a microemulsion, the herbicide is prepared from the herbicidal composition, adjuvants and water; the adjuvants include cosolvents, solvents, emulsifiers, defoaming agents and antifreeze agents;

[0016] Specifically, the cosolvent is N-methylpyrrolidone;

[0017] The solvent is N,N-dimethylacetamide;

[0018] The emulsifier is dodecylphenol polyoxyethylene ether;

[0019] The defoaming agent is organosiloxane;

[0020] The antifreeze agent is glycerol.

[0021] Based on the total mass of the herbicide, the mass percentages of the components are as follows: 10% to 50% of the herbicidal composition, 2.5% to 5.8% of the cosolvent, 12.0% to 17.8% of the solvent, 15.0% to 19.6% of the emulsifier, 0.1% to 0.8% of the defoaming agent, 2.3% to 4.5% of the antifreeze agent, and the balance being deionized water.

[0022] When the herbicide is an emulsifiable concentrate, the herbicide is prepared from the herbicidal composition, an emulsifier, a stabilizer, a cosolvent and corn oil;

[0023] Specifically, the emulsifier is calcium dodecylbenzenesulfonate;

[0024] The stabilizer is epoxidized soybean oil;

[0025] The cosolvent is N-methylpyrrolidone.

[0026] Based on the total mass of the herbicide, the mass percentages of the components are as follows: 10% to 50% of the herbicidal composition, 3.0% to 5.7% of the emulsifier, 2.2% to 4.5% of the stabilizer, 2.0% to 4.9% of the cosolvent, and the balance being corn oil.

[0027] The present invention also provides the use of the above-mentioned herbicidal composition or herbicide in controlling weeds in the field;

[0028] Specifically, the herbicidal composition or herbicide is used to control weeds in quinoa fields.

[0029] In the above application, the weeds are at least one of purslane, polygonum sylvestris, wild millet and wild oats.

[0030] Finally, the present invention provides a method for weeding in a quinoa field, comprising the following steps:

[0031] Spraying the above-mentioned herbicidal composition or herbicide on the quinoa field;

[0032] Specifically, the spraying time is when the quinoa has 3 to 5 leaves.

[0033] The present invention has the following beneficial effects:

[0034] (1) The herbicidal composition of the present invention is highly safe and has no phytotoxicity to quinoa.

[0035] (2) The synergistic effect of sethoxydim and ethoxyfuroxan is obvious after compounding, and the herbicide combination has a significant joint synergistic effect on common weeds in quinoa fields; it expands the weed control spectrum and has excellent control effects on common weeds in quinoa fields;

[0036] (3) The herbicidal composition of the present invention has low control costs for quinoa fields and is easy to promote and use; it significantly reduces labor costs, improves labor productivity, and increases growers' income. DETAILED DESCRIPTION

[0037] The present invention will be further described in detail below in conjunction with specific embodiments. The examples given are only for illustrating the present invention, not for limiting the scope of the present invention.

[0038] The experimental methods in the following examples are conventional methods unless otherwise specified.

[0039] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0040] The test agents used in the following examples are commercially available 94 wt% sethoxydim technical and 96 wt% ethoxanyl technical.

[0041] Example 1: 10% sethoxydim-ethoxyfuroxan microemulsion (1:4)

[0042] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 2%, ethoxyfuroxan 8%, N-methylpyrrolidone (cosolvent) 2.7%, N,N-dimethylacetamide (solvent) 12.3%, dodecylphenol polyoxyethylene ether (emulsifier) 15.3%, glycerol (antifreeze) 2.5%, organosiloxane (defoaming agent) 0.2%, and deionized water is added to 100%.

[0043] The preparation steps are as follows: weigh sethoxydim, ethoxyfuroxan, a cosolvent and a solvent according to a proportion, put them into a reaction kettle and stir and mix them evenly, then add an emulsifier, a defoamer and an antifreeze agent and stir and mix them evenly, and finally add deionized water and continue to stir evenly to obtain a microemulsion, which is a finished product after passing the inspection.

[0044] Example 2, 18% sethoxydim·ethoxyfuroxan microemulsion (1:5)

[0045] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 3%, ethoxyfuroxim 15%, N-methylpyrrolidone (cosolvent) 3.5%, N,N-dimethylacetamide (solvent) 14.2%, dodecylphenol polyoxyethylene ether (emulsifier) 16.5%, glycerol (antifreeze) 2.9%, organosiloxane (defoaming agent) 0.3%, and deionized water is added to 100%.

[0046] The preparation method is the same as that in Example 1.

[0047] Example 3, 27% sethoxydim·ethoxyfuroxan microemulsion (1:8)

[0048] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 3%, ethoxyfuroxim 24%, N-methylpyrrolidone (cosolvent) 4.3%, N,N-dimethylacetamide (solvent) 16.8%, dodecylphenol polyoxyethylene ether (emulsifier) 17.9%, glycerol (antifreeze) 3.5%, organosiloxane (defoaming agent) 0.4%, and deionized water is added to 100%.

[0049] The preparation method is the same as that in Example 1.

[0050] Example 4: 32% sethoxydim-ethoxyfuroxan microemulsion (1:7)

[0051] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 4%, ethoxyfuroxim 28%, N-methylpyrrolidone (cosolvent) 4.8%, N,N-dimethylacetamide (solvent) 17.6%, dodecylphenol polyoxyethylene ether (emulsifier) 19.3%, glycerol (antifreeze) 3.9%, organosiloxane (defoaming agent) 0.4%, and deionized water is added to 100%.

[0052] The preparation method is the same as that in Example 1.

[0053] Example 5, 44% sethoxydim·ethoxyfuroxan microemulsion (1:10)

[0054] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 4%, ethoxyfuroxim 40%, N-methylpyrrolidone (cosolvent) 5.6%, N,N-dimethylacetamide (solvent) 17.4%, dodecylphenol polyoxyethylene ether (emulsifier) 19.1%, glycerol (antifreeze) 4.1%, organosiloxane (defoaming agent) 0.5%, and deionized water is added to 100%.

[0055] The preparation method is the same as that in Example 1.

[0056] Example 6, 14% sethoxydim-ethoxyfuroxan emulsifiable concentrate (1:6)

[0057] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 2%, ethoxyfuroxim 12%, calcium dodecylbenzenesulfonate (emulsifier) 3.2%, epoxidized soybean oil (stabilizer) 2.4%, N-methylpyrrolidone (solvent) 2.1%, and industrial corn oil is supplemented to 100%.

[0058] The preparation steps are as follows: weigh sethoxydim, ethoxyfuroxan and a cosolvent in proportion and dissolve them in a reactor, then add an emulsifier, a stabilizer and a cosolvent, stir evenly, and filter through a filter to obtain an emulsifiable concentrate. According to product quality control indicators, the finished product is qualified after inspection.

[0059] Example 7, 20% sethoxydim-ethoxyfuroxan emulsifiable concentrate (1:9)

[0060] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 2%, ethoxyfuroxan 18%, calcium dodecylbenzenesulfonate (emulsifier) 3.8%, epoxidized soybean oil (stabilizer) 2.9%, N-methylpyrrolidone (solvent) 2.7%, and industrial corn oil is supplemented to 100%.

[0061] The preparation method is the same as that of Example 6.

[0062] Example 8, 28% sethoxydim-ethoxyfuroxan emulsifiable concentrate (1:3)

[0063] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 7%, ethoxyfuroxim 21%, calcium dodecylbenzenesulfonate (emulsifier) 4.9%, epoxidized soybean oil (stabilizer) 3.7%, N-methylpyrrolidone (solvent) 3.3%, and industrial corn oil is supplemented to 100%.

[0064] The preparation method is the same as that of Example 6.

[0065] Example 9, 36% sethoxydim-ethoxyfuroxan emulsifiable concentrate (1:8)

[0066] In the herbicide of this example, the mass percentage of each component is: sethoxydim 4%, ethoxyfuroxan 32%, calcium dodecylbenzenesulfonate (emulsifier) 5.2%, epoxidized soybean oil (stabilizer) 3.9%, N-methylpyrrolidone (cosolvent) 3.6%, and industrial corn oil is supplemented to 100%.

[0067] The preparation method is the same as that of Example 6.

[0068] Example 10, 50% sethoxydim-ethoxyfuroxan emulsifiable concentrate (1:9)

[0069] In the herbicide of this embodiment, the mass percentage of each component is: sethoxydim 5%, ethoxyfuroxan 45%, calcium dodecylbenzenesulfonate (emulsifier) 5.5%, epoxidized soybean oil (stabilizer) 4.3%, N-methylpyrrolidone (solvent) 4.7%, and industrial corn oil is supplemented to 100%.

[0070] The preparation method is the same as that of Example 6.

[0071] Example 11

[0072] 1. Indoor efficacy test

[0073] 1. Purpose of the study

[0074] The combined effect of sethoxydim and ethoxyfuroxan was determined by indoor bioassay.

[0075] 2. Materials and Methods

[0076] The indoor efficacy test was carried out in an artificial light culture room of the Institute of Cereals and Oils Crops of Hebei Academy of Agricultural and Forestry Sciences according to the Gowing method in "NY / T1155.7-2006 Pesticide Indoor Bioassay Test Guidelines Herbicides Part 7: Determination of Combined Effects of Mixtures".

[0077] The target weeds selected were purslane (Portulaca oleracea L.), sorrel (Persicaria lapathifolia L.), wild millet (Eriochloa villosa (Thunb.) Kunth), and wild oats (Avena fatua L.), which are common in quinoa fields in Zhangbei County, and their germination rates were all greater than 90%.

[0078] The test agents are 94 wt% sethoxydim technical and 96 wt% ethoxanol technical on the market.

[0079] The above four weed seeds were evenly sown in a plastic flower pot with a diameter of 10 cm, then covered with about 0.5 cm of soil with a sieve, placed in a plastic tray filled with water, and allowed to gradually seep in. Water was replenished by infiltration irrigation at the bottom of the flower pot every 3 days to maintain soil moisture. When the weeds grew to 2 leaves, seedlings were planted, and 10 weeds were retained in each pot.

[0080] Use a 1 / 10,000 electronic balance to accurately weigh the original drug, add 1 mL of N-methylpyrrolidone to the original drug until it is completely dissolved, and finally dilute to 500 mL with a 0.1% Tween 80 aqueous solution. When the above four weeds grow to the 3-4 leaf stage, use a 3WP-2000 walking spray tower to spray the stems and leaves of the weeds. Each treatment is repeated 4 times.

[0081] The synergistic effect of the mixture was evaluated using the Gowing method. The fresh weight of the aboveground weeds was measured 21 days after application. The calculation was: E (actual control efficacy of the composition) = (fresh weight of the blank control - fresh weight of the treatment) × 100% / fresh weight of the blank control; E0 (theoretical control efficacy of the composition) = E1 + E2 × (100 - E1) / 100, where E1 and E2 are the actual control efficacy of the corresponding doses of sethoxydim and ethoprenate, respectively. When E - E0 < -10%, the components of the composition exhibit antagonistic effects; when -10% ≤ E - E0 ≤ 10%, the components exhibit additive effects; and when E - E0 > 10%, the components exhibit synergistic effects.

[0082] Table 1 Dosage table for the combined action of sethoxydim and ethopoxetine in the laboratory (g / hm 2 )

[0083]

[0084] The test results show (see Table 1) that the control effect of sethoxydim on purslane is 8.5% to 13.7%, the control effect on Polygonum sylvestris is 5.7% to 10.9%, the control effect on wild oats is 56.4% to 88.6%, and the control effect on wild millet is 52.1% to 86.7%; the control effect of ethofumesate on purslane is 52.4% to 85.3%, the control effect on Polygonum sylvestris is 53.8% to 83.7%, the control effect on wild oats is 4.1% to 7.2%, and the control effect on wild millet is 5.1% to 7.5%.

[0085] When sethoxydim and ethoxydim are mixed in a certain ratio, their control efficacy against four weeds is significantly enhanced. Combined action assays (see Table 1) show that the combined sethoxydim and ethoxydim achieve effective control against purslane, Polygonum sylvestris, wild oats, and wild millet, reaching 68.5% to 100%, 67.9% to 98.4%, 71.3% to 100%, and 54.5% to 87.7%, respectively. This significantly enhances the control efficacy of sethoxydim and ethoxydim against the four weeds, and also demonstrates good control efficacy against less sensitive weeds, broadening the weed control spectrum. The combined effect is greater than 10%, demonstrating a synergistic effect (Table 1).

[0086] 2. Weed control and safety test of sethoxydim and ethoxyfurox in quinoa fields

[0087] The herbicides prepared in Examples 1, 3, 5, 7, and 9 were used in this test. The control agents were commercially available 12.5 wt% sethoxydim emulsifiable concentrate (Shandong Binnong Technology Co., Ltd.), 20 wt% ethofuroxol emulsifiable concentrate (Jiangsu Good Harvest Wayne Agrochemical Co., Ltd.), and the quinoa variety was "Yanli No. 2". The test site was Xishungou Village, Zhangbei County, Hebei Province.

[0088] Before planting quinoa, clean the land and plow it thoroughly to a depth of 20cm. Finely tamp and level the soil to retain moisture, then cover with black mulch. Quinoa should be sown spot-seeded at a depth of 2cm, with row spacing of 35cm and plant spacing of 20cm. A seeding rate of 0.3kg / mu should be applied. Before sowing, apply 10kg / mu of urea, 20kg / mu of diammonium phosphate, and 5kg / mu of potassium sulfate. When the quinoa seedlings have 8-9 true leaves, apply 5kg / mu of urea, 10kg / mu of diammonium phosphate, and 2kg / mu of potassium sulfate. Mix 25% thiamethoxam-metalaxyl suspension seed dressing with base fertilizer to control underground pests. After quinoa seedlings emerge, spray 50mL / mu of 5% lambda-hypothrin emulsion in water and 30mL / mu of 20% acetamiprid solution to control aboveground pests. 80% mancozeb wettable powder (800 times diluted), 10% difenoconazole (2000 times diluted) and 8% hydroxyproline wettable powder (2000 times diluted) were sprayed to control downy mildew, leaf spot and root rot. The average weed density in the blank control area of the experimental field was 75 plants / m2. 2 Among them, Portulaca oleracea accounted for 41.3%, Rumex sylvestris accounted for 15.8%, Oats accounted for 21.1%, and Millet accounted for 20.5%. The weed density and distribution in the experimental treatment area were uniform and consistent with those of the blank control.

[0089] The field test was conducted when quinoa was at the 3-5 leaf stage and weeds were at the 2-5 leaf stage. The spray volume was 40 L / mu. The spraying equipment was the HD400 backpack sprayer produced by Singapore Linong Pte Ltd., with a fan-shaped nozzle. A total of 7 drug treatments were set up in the quinoa field, as well as a blank control treatment and manual weeding treatment. Each treatment area was 20 m 2 The experiments were repeated three times and arranged in random blocks. The drugs and dosages of each treatment are shown in Table 2.

[0090] Measure 1m2 per treatment 21 days after application 2 The fresh weight of the aboveground parts of weeds was used to calculate the fresh weight control effect of the pesticide on weeds. The calculation formula was: weed fresh weight control effect (%) = (fresh weight of weeds in the control area - fresh weight of weeds in the treatment area) × 100% / fresh weight of weeds in the control area.

[0091] Yield measurement is carried out in each plot when quinoa is harvested.

[0092] Table 2 Weed control effect of herbicides

[0093]

[0094]

[0095] The test results show that 10% sethoxydim·ethoxyfuroxan microemulsion, 27% sethoxydim·ethoxyfuroxan microemulsion, 44% sethoxydim·ethoxyfuroxan microemulsion, 20% sethoxydim·ethoxyfuroxan emulsion, 36% sethoxydim·ethoxyfuroxan emulsifiable concentrate (Examples 1, 3, 5, 7, 9) 1200g / hm 2 The treatment had an excellent control effect on weeds in quinoa fields. The total fresh weight control efficiency of weeds was above 90% 21 days after application, which was significantly better than that of sethoxydim and ethopoxam alone (Table 2).

[0096] Table 3 Effects of herbicides on quinoa yield

[0097] Processing Name <![CDATA[Dose g / hm 2 > Quinoa yield (kg / mu) 10% sethoxydim·ethoxyfuroxan microemulsion 1200 173.3 27% sethoxydim·ethoxyfuroxan microemulsion 1200 174.9 44% sethoxydim·ethoxyfuroxan microemulsion 1200 175.6 20% sethoxydim·ethoxyfurantoin emulsifiable concentrate 1200 173.5 36% sethoxydim·ethoxyfurantoin emulsifiable concentrate 1200 175.1 12.5% sethoxydim emulsifiable concentrate 300 110.5 20% Ethofuroxol EC 1500 102.3 Clear water control - 60.3 Manual weeding - 176.5

[0098] After treatment with the herbicide of the present invention, the growth and appearance of quinoa were normal, with no symptoms of pesticide damage. The yield measurement results at harvest showed (Table 3) that it was significantly better than the control agent and blank control treatments, and had no significant difference from the manual weeding treatment.

Claims

1. A herbicide composition for quinoa fields, the active ingredients of which are sethoxydim and ethoxyfuroxim; The mass ratio of sethoxydim to ethopoxatin is 1:3 to 1:

10.

2. A herbicide for quinoa fields, characterized in that: The active ingredient of the herbicide is the herbicide composition for quinoa fields according to claim 1.

3. The herbicide for quinoa fields according to claim 2, characterized in that: The herbicide is a microemulsion or emulsifiable concentrate.

4. The herbicide for quinoa fields according to claim 2 or 3, characterized in that: The mass of the herbicidal composition used for quinoa fields accounts for 10% to 50% of the total mass of the herbicide.

5. Use of the herbicidal composition for quinoa fields according to claim 1 or the herbicide for quinoa fields according to any one of claims 2 to 4 in controlling weeds in quinoa fields.

6. The use according to claim 5, characterized in that: The weeds are at least one of purslane, polygonum sylvestris, wild millet and wild oats.

7. A method for weeding in a quinoa field, comprising the following steps: The herbicide composition for quinoa fields according to claim 1 or the herbicide for quinoa fields according to any one of claims 2 to 4 is sprayed on the quinoa field.

8. The method for weeding quinoa fields according to claim 7, characterized in that: The spraying time is when the quinoa has 3 to 5 leaves.

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