Composition for improving intestinal health, preparation method and application thereof

Abstract

The present invention provides a composition for improving intestinal health, a preparation method and its application, and belongs to the technical field of health foods. The composition includes the following components: oligofructose, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, blue mussel oligopeptide, oligoisomaltose, carrot powder, spinach powder and bitter melon powder. During the implementation of the present invention, it was found that controlling the mass ratio of seaweed polysaccharide, blue mussel oligopeptide and oligoisomaltose can selectively proliferate bifidobacteria, and the acetic acid and lactic acid produced after the metabolism of bifidobacteria can inhibit the proliferation of harmful bacteria, thereby significantly promoting gastrointestinal motility, thereby achieving the effect of moisturizing the intestine and promoting bowel movements.

Description

Technical Field

[0001] The present application belongs to the technical field of health foods, and specifically relates to a composition for improving intestinal health, a preparation method and its application. Background Art

[0002] Constipation can be a problem to varying degrees for people affected by factors such as work stress, lack of exercise, and an unbalanced diet, as well as those experiencing special physiological periods, such as during pregnancy and postpartum women. Constipation can cause numerous side effects, including intestinal diseases, toxin accumulation, and heart disease burden. Therefore, the development of a safe and effective product that promotes bowel movements is crucial.

[0003] Dietary fiber, as the seventh type of nutrient, has significant preventive and therapeutic effects on constipation and other conditions. Dietary fiber refers to the sum of edible plant ingredients, carbohydrates, and similar substances that can be digested and absorbed by the small intestine and partially or completely fermented in the large intestine. This includes polysaccharides, oligosaccharides, lignin, and related plant substances. It can be divided into water-soluble dietary fiber and water-insoluble dietary fiber. Water-soluble dietary fiber can increase the water-holding capacity of feces and has a laxative effect. Insoluble dietary fiber absorbs water and swells, increasing the mass and volume of feces. It mechanically promotes intestinal wall tissue, promotes intestinal peristalsis, and accelerates the passage of food residues through the intestines, preventing constipation.

[0004] Prebiotics are food ingredients that are indigestible or difficult to digest by humans and selectively stimulate the growth and activity of physiologically active bacteria (probiotics) in the colon, thereby producing health benefits for the host. There are many types of prebiotics, including oligosaccharides, polysaccharides, herbal extracts, protein hydrolysates, polyols, and more. The oligosaccharides that are commercially produced in large quantities are primarily those with bifidus-like properties. The physiological functions of prebiotics are primarily achieved by promoting the growth of beneficial bacteria in the human intestine and optimizing the balance of the bacterial flora. Furthermore, functional oligosaccharides acting as prebiotics also function as dietary fiber, increasing stool water retention and volume, thereby facilitating excretion. They also absorb anions and bile acids in the intestine, effectively lowering blood lipids and cholesterol.

[0005] Because dietary fiber and prebiotics are effective in promoting gastrointestinal motility and accelerating excretion, a large number of prior art patent applications have been filed targeting these two components. For example, Chinese patent CN110810855A discloses a dietary fiber composition with laxative properties, comprising the following components by mass: 40-60% water-soluble dietary fiber; 30-50% insoluble dietary fiber; 5-10% oligosaccharides; and 2-7% isomalt. The water-soluble and insoluble dietary fibers in this composition originate from different sources, resulting in different mechanisms for laxative properties. Furthermore, the composition works synergistically with the oligosaccharide-based prebiotics, significantly promoting the proliferation of probiotics in the intestines and fully leveraging the probiotics' intestinal regulatory effects. This composition, while treating constipation, regulates the intestinal flora and ultimately cures constipation. Another example is Chinese patent application CN104397188A, which discloses a low-calorie solid milk tea containing prebiotics and its preparation method. The raw materials include skim milk powder, maltodextrin, preferred tea powder, water-soluble dietary fiber, prebiotics, wheat oligopeptides, erythritol, and stevia. This milk tea product is rich in prebiotic factors, dietary fiber, small molecule peptides, trace elements, and other nutrients, is extremely low in fat and calories, and also has laxative effects. It is simple to prepare, inexpensive, suitable for a wide range of people, and has broad market prospects.

[0006] But, after deliberation, it is found that only taking in dietary fiber and prebiotic components is not very remarkable to the effect of moistening intestines and relieving constipation, and intestinal flora can not be better stabilized, thus causing the product to have obvious effect during taking, and after stopping taking, the effect is obviously weakened, as previously applied for CN115644457A to disclose a composition preparation method and application thereof for improving intestinal health, the composition includes: oligofructose, blue mussel oligopeptides, lactitol, resistant dextrin, inulin, shea butter, zizyphus chinensis leaves, corn oligopeptide powder. The composition is based on food grade raw materials as main component, makes full use of the synergistic effect of prebiotics and dietary fiber, has the effects such as increasing fecal moisture, increasing fecal volume, reducing defecation time, increasing defecation frequency, but the product can not better stabilize intestinal flora, and product dependence can be produced after taking, therefore it is necessary to develop a kind of composition that can effectively improve intestinal flora, promote beneficial bacteria breeding, and the composition of stabilizing flora. Summary of the Invention

[0007] In response to the problems existing in the prior art, the present invention provides a composition, preparation method and application thereof that can improve intestinal health based on previous research. The composition can not only achieve the effect of moisturizing the intestine and promoting bowel movements, but also better regulate the intestinal flora, stabilize beneficial bacteria, and promote the reproduction of beneficial bacteria, thereby improving intestinal health from the root.

[0008] In order to achieve the above objectives, this application adopts the following technical solutions:

[0009] In one aspect, the present invention provides a composition capable of improving intestinal health, comprising the following components by weight:

[0010] 50-100 parts of oligofructose, 10-50 parts of L-arabinose, 10-50 parts of resistant dextrin, 0.1-5 parts of inulin, 0.1-10 parts of seaweed polysaccharide, 0.01-1 parts of chicken gizzard peptide, 0.01-2 parts of citrus fiber, 0.1-2 parts of beta-glucan, 0.01-1 parts of carrot powder, 0.01-1 parts of spinach powder and 0.01-1 parts of bitter melon powder.

[0011] Preferably, the composition capable of improving intestinal health comprises the following components by weight:

[0012] 60-90 parts of oligofructose, 15-45 parts of L-arabinose, 20-40 parts of resistant dextrin, 0.2-4 parts of inulin, 0.2-9 parts of seaweed polysaccharide, 0.02-0.9 parts of chicken gluconate peptide, 0.02-1.5 parts of citrus fiber, 0.15-1.9 parts of beta-glucan, 0.02-1 parts of carrot powder, 0.02-1 parts of spinach powder and 0.02-1 parts of bitter melon powder.

[0013] More preferably, the composition capable of improving intestinal health comprises the following components in parts by weight:

[0014] 70-80 parts of oligofructose, 20-30 parts of L-arabinose, 30-40 parts of resistant dextrin, 0.5-1 part of inulin, 0.5-2 parts of seaweed polysaccharide, 0.05-0.3 parts of chicken gluconate peptide, 0.05-0.3 parts of citrus fiber, 0.15-0.4 parts of beta-glucan, 0.02-0.05 parts of carrot powder, 0.02-0.05 parts of spinach powder and 0.02-0.05 parts of bitter melon powder.

[0015] The present invention unexpectedly discovered during implementation that controlling the mass ratio of chicken gizzard peptide, citrus fiber, and beta-glucan to be 1:1-2:2-10 can better stabilize the intestinal flora, promote the proliferation of beneficial bacteria, and achieve the effect of inhibiting harmful bacteria. In addition, controlling the mass ratio of chicken gizzard peptide, citrus fiber, and beta-glucan can maintain the stability of intestinal flora for a long time, and after stopping use of the product, the intestinal flora can still maintain the stability of beneficial bacteria for a long time.

[0016] Preferably, the mass ratio of the chicken gizzard peptide, citrus fiber and β-glucan is 1:1:3.

[0017] Further preferably, the composition capable of improving intestinal health comprises the following components in parts by weight:

[0018] 80 parts of polyfructose, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.5 parts of seaweed polysaccharide, 0.05 parts of chicken gizzard peptide, 0.05 parts of citrus fiber, 0.15 parts of beta-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder and 0.02 parts of bitter melon powder.

[0019] In some preferred embodiments, the composition capable of improving intestinal health further comprises the following components by weight: 0.05-0.15 parts of blue mussel oligopeptide and 0.1-3 parts of isomaltooligosaccharide.

[0020] In addition, during the implementation of the present invention, it was found that controlling the mass ratio of seaweed polysaccharides, blue mussel oligopeptides, and isomaltooligosaccharide can selectively proliferate bifidobacteria, and the acetic acid and lactic acid produced after the metabolism of bifidobacteria can inhibit the proliferation of harmful bacteria, thereby significantly promoting gastrointestinal motility, thereby achieving the effect of moisturizing the intestines and promoting bowel movements. Among them, the mass ratio of seaweed polysaccharides, blue mussel oligopeptides, and isomaltooligosaccharide is 5-50:1:2-20; preferably, the mass ratio of seaweed polysaccharides, blue mussel oligopeptides, and isomaltooligosaccharide is 6.25:1:6.25.

[0021] In addition, the present invention can significantly improve the absorption efficiency of the product by controlling the mass ratio of carrot powder, spinach powder and bitter melon powder, that is, the bioavailability of the product can be improved, so that the prepared product can be better absorbed; the mass ratio of the carrot powder, spinach powder and bitter melon powder is 1:1:1.

[0022] As a preferred embodiment, the composition capable of improving intestinal health comprises the following components by weight: 80 parts of oligofructose, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.5 parts of seaweed polysaccharides, 0.05 parts of chicken gizzard peptides, 0.05 parts of citrus fiber, 0.15 parts of β-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder and 0.02 parts of bitter melon powder, 0.08 parts of blue mussel oligopeptides and 0.5 parts of isomaltooligosaccharide.

[0023] The components of the present invention are added with a variety of prebiotic ingredients. Fructooligosaccharide can significantly improve the proportion of microbial population in the intestine. It is an activation and proliferation factor for intestinal bifidobacteria, can reduce and inhibit the production of intestinal putrefactive substances, inhibit the growth of harmful bacteria, and regulate intestinal balance; L-arabinose has the effect of preventing constipation; resistant dextrin can improve intestinal flora imbalance; inulin can regulate intestinal microbial flora, improve intestinal health, and prevent constipation; isomaltooligosaccharide can promote the proliferation of intestinal bifidobacteria, inhibit the formation of harmful intestinal bacteria and putrefactive substances, increase vitamin content, and enhance the body's immunity.

[0024] In addition, polysaccharide components and dietary fiber are added to the components of the present application, which can not only significantly improve the long-term stability of the product, but also ensure the stability of the intestinal flora, and can significantly reduce the patient's dependence on the product.

[0025] On the other hand, the present invention also provides a method for preparing the above-mentioned composition capable of improving intestinal health, comprising the following steps:

[0026] Fructooligosaccharide, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, carrot powder, spinach powder, blue mussel oligopeptide and isomaltooligosaccharide are uniformly mixed and added into water, stirred until completely dissolved, sterilized, filled, and sterilized again to obtain the composition.

[0027] The present application also provides the use of the composition in preparing a preparation for improving intestinal health.

[0028] Compared with the prior art, the present invention has the following advantages:

[0029] (1) During the implementation of the present invention, it was unexpectedly found that controlling the mass ratio of chicken gizzard peptide, citrus fiber and β-glucan to 1-2:1:1-10 can better stabilize the intestinal flora, promote the proliferation of beneficial bacteria, and achieve the effect of inhibiting harmful bacteria; in addition, controlling the mass ratio of chicken gizzard peptide, citrus fiber and β-glucan can maintain the stability of the intestinal flora for a long time, and after stopping the use of the product, the intestinal flora can still maintain the stability of beneficial bacteria for a long time;

[0030] (2) During the implementation of the present invention, it was found that controlling the mass ratio of seaweed polysaccharides, blue mussel oligopeptides and isomaltooligosaccharide can selectively proliferate bifidobacteria, and the acetic acid and lactic acid produced by the metabolism of bifidobacteria can inhibit the proliferation of harmful bacteria, thereby significantly promoting gastrointestinal motility, thereby achieving the effect of moisturizing the intestines and promoting bowel movements;

[0031] (3) The present invention can significantly improve the absorption efficiency of the product by controlling the mass ratio of carrot powder, spinach powder and bitter melon powder to 1:1:1, that is, it can improve the bioavailability of the product, so that the prepared product can be better absorbed. DETAILED DESCRIPTION

[0032] The features described above in the present invention, or in the embodiments, may be combined in any combination. All features described in this specification may be used in conjunction with any method or form, and each feature disclosed in this specification may be replaced by any alternative feature that provides the same, equivalent, or similar purpose. Therefore, unless otherwise specified, the features disclosed are merely general examples of equivalent or similar features.

[0033] The present invention will be further described below in conjunction with specific examples. These examples are intended to illustrate the present invention only and are not intended to limit the scope of the invention. The following examples are implementation methods for which specific conditions are noted, generally according to conventional conditions or according to the conditions recommended by the manufacturer. Unless otherwise specified, all percentages and fractions are by weight.

[0034] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those known to those skilled in the art. Furthermore, any methods and materials similar or equivalent to those described herein can be applied to the methods of the present invention. The preferred methods and materials described herein are for illustrative purposes only.

[0035] The raw materials used in the present invention are all common commercially available products.

[0036] Example 1 A composition capable of improving intestinal health

[0037] The components include the following in parts by weight:

[0038] 50 parts of oligofructose, 10 parts of L-arabinose, 10 parts of resistant dextrin, 0.1 parts of inulin, 0.1 parts of seaweed polysaccharides, 0.01 parts of chicken gizzard peptides, 0.01 parts of citrus fiber, 0.1 parts of beta-glucan, 0.01 parts of carrot powder, 0.01 parts of spinach powder, 0.01 parts of bitter melon powder, 0.05 parts of blue mussel oligopeptides and 0.1 parts of isomaltooligosaccharide.

[0039] Preparation method:

[0040] The oligofructose, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, carrot powder, spinach powder, bitter melon powder, blue mussel oligopeptide and isomaltooligosaccharide in the above-mentioned formula content are evenly mixed and added into water, stirred until completely dissolved, sterilized, filled, and sterilized again to obtain the composition.

[0041] Example 2 A composition capable of improving intestinal health

[0042] The components include the following in parts by weight:

[0043] 100 parts of oligofructose, 50 parts of L-arabinose, 50 parts of resistant dextrin, 5 parts of inulin, 5 parts of seaweed polysaccharide, 1 part of chicken gizzard peptide, 2 parts of citrus fiber, 2 parts of beta-glucan, 1 part of carrot powder, 1 part of spinach powder, 1 part of bitter melon powder, 0.15 parts of blue mussel oligopeptide and 3 parts of isomaltooligosaccharide.

[0044] Preparation method:

[0045] The oligofructose, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, carrot powder, spinach powder, bitter melon powder, blue mussel oligopeptide and isomaltooligosaccharide in the above-mentioned formula content are evenly mixed and added into water, stirred until completely dissolved, sterilized, filled, and sterilized again to obtain the composition.

[0046] Example 3 A composition capable of improving intestinal health

[0047] The components include the following in parts by weight:

[0048] 60 parts of oligofructose, 45 parts of L-arabinose, 20 parts of resistant dextrin, 4 parts of inulin, 0.2 parts of seaweed polysaccharide, 0.9 parts of chicken gizzard peptide, 1.5 parts of citrus fiber, 1.9 parts of beta-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder, 0.02 parts of bitter melon powder, 0.01 parts of blue mussel oligopeptides and 0.2 parts of isomaltooligosaccharide.

[0049] Preparation method:

[0050] The oligofructose, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, carrot powder, spinach powder, bitter melon powder, blue mussel oligopeptide and isomaltooligosaccharide in the above-mentioned formula content are evenly mixed and added into water, stirred until completely dissolved, sterilized, filled, and sterilized again to obtain the composition.

[0051] Example 4 A composition capable of improving intestinal health

[0052] The components include the following in parts by weight:

[0053] 80 parts of oligofructose, 30 parts of L-arabinose, 40 parts of resistant dextrin, 1 part of inulin, 2 parts of seaweed polysaccharide, 0.3 parts of chicken gizzard peptide, 0.3 parts of citrus fiber, 0.6 parts of beta-glucan, 0.05 parts of carrot powder, 0.05 parts of spinach powder, 0.05 parts of bitter melon powder, 0.05 parts of blue mussel oligopeptides and 0.3 parts of isomaltooligosaccharide.

[0054] Preparation method:

[0055] The oligofructose, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, carrot powder, spinach powder, bitter melon powder, blue mussel oligopeptide and isomaltooligosaccharide in the above-mentioned formula content are evenly mixed and added into water, stirred until completely dissolved, sterilized, filled, and sterilized again to obtain the composition.

[0056] Example 5 A composition capable of improving intestinal health

[0057] The components include the following in parts by weight:

[0058] 80 parts of oligofructose, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.5 parts of seaweed polysaccharide, 0.05 parts of chicken gizzard peptide, 0.05 parts of citrus fiber, 0.15 parts of beta-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder and 0.02 parts of bitter melon powder, 0.08 parts of blue mussel oligopeptides and 0.5 parts of isomaltooligosaccharide.

[0059] Preparation method:

[0060] The oligofructose, L-arabinose, resistant dextrin, inulin, seaweed polysaccharide, chicken gizzard peptide, citrus fiber, β-glucan, carrot powder, spinach powder, bitter melon powder, blue mussel oligopeptide and isomaltooligosaccharide in the above-mentioned formula content are evenly mixed and added into water, stirred until completely dissolved, sterilized, filled, and sterilized again to obtain the composition.

[0061] Comparative Example 1

[0062] The difference from Example 5 is that all chicken gizzard peptides are replaced with seaweed polysaccharides, that is, the following components are included in parts by weight:

[0063] 80 parts of oligofructose, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.55 parts of seaweed polysaccharide, 0.05 parts of citrus fiber, 0.15 parts of beta-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder and 0.02 parts of bitter melon powder, 0.08 parts of blue mussel oligopeptides and 0.5 parts of isomaltooligosaccharide.

[0064] The preparation method is the same as that of Example 5 (excluding chicken glucoside peptide).

[0065] Comparative Example 2

[0066] The difference from Example 5 is that seaweed polysaccharide is replaced by β-glucan, that is, the following components are included in parts by weight:

[0067] 80 parts of fructooligosaccharides, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.05 parts of chicken gizzard peptides, 0.05 parts of citrus fiber, 0.65 parts of beta-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder and 0.02 parts of bitter melon powder, 0.08 parts of blue mussel oligopeptides and 0.5 parts of isomaltooligosaccharide.

[0068] The preparation method is the same as that of Example 5 (excluding seaweed polysaccharides).

[0069] Comparative Example 3

[0070] The difference from Example 5 is that the mass ratio of chicken gizzard peptide, citrus fiber and β-glucan is 1:3:1, that is, 0.05 parts of seaweed polysaccharide, 0.15 parts of chicken gizzard peptide and 0.05 parts of β-glucan, and the contents of other components and the preparation method are the same as those in Example 5.

[0071] Comparative Example 4

[0072] 80 parts of oligofructose, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.5 parts of seaweed polysaccharide, 0.05 parts of chicken gizzard peptide, 0.05 parts of citrus fiber, 0.15 parts of beta-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder, 0.02 parts of bitter melon powder and 0.58 parts of xylo-oligosaccharide.

[0073] The preparation method is the same as that of Example 5 (the blue mussel oligopeptide and isomaltooligosaccharide are replaced by xylooligosaccharide).

[0074] Comparative Example 5

[0075] The difference from Example 5 is that bitter melon powder is omitted, that is, 0.02 parts of carrot powder and 0.02 parts of spinach powder are used, and the contents of other components and the preparation method are the same as those in Example 5.

[0076] Comparative Example 6

[0077] The product prepared in Example 1 of Chinese patent CN 110810855 A.

[0078] Comparative Example 7

[0079] The product prepared in Example 3 of Chinese patent CN 102630948 A.

[0080] Effect experiment-detection of mouse fecal flora

[0081] (1) Animal selection:

[0082] 150 clean-grade KM male mice were selected, adaptively raised for 7 days, and randomly divided into 15 groups, with 10 mice in each group;

[0083] (2) Dosage and experimental plan:

[0084] Lincomycin hydrochloride: dilute 64 μL of lincomycin hydrochloride to 1 mL with normal saline;

[0085] ① Blank group: 10 mL / kg normal saline was administered orally daily for 21 days;

[0086] ② Model group: 10 mL / kg of lincomycin hydrochloride was administered orally for the first three days, and then 10 mL / kg of normal saline was administered orally every day for 21 days;

[0087] ③ Positive group: 10 mL / kg of lincomycin hydrochloride was administered orally for the first three days, and then 20 mg / kg of Lizhu Changle was administered orally every day for 21 days;

[0088] ④ Experimental group: The rats were divided into the compositions prepared in Examples 1-5 and Comparative Examples 1-7 and were orally administered with 10 mL / kg of lincomycin hydrochloride for the first three days, and then 200 mg / kg of the composition sample every day for 21 days;

[0089] Fifteen models were established. 0.1 g of fresh feces from mice after modeling and 0.1 g of feces from mice after 21 days of continuous administration were placed in centrifuge tubes treated with deionized water and diluted with normal saline to 10 -5 , evenly spread 5 μL each on BBL, LBS, EMB, and EC selection culture media, culture BBL and LBS anaerobically for 72 hours, and culture EMB and EC aerobically for 24 hours, take the logarithm of the results, and count the colonies.

[0090] The fecal flora counts of mice after modeling are shown in Table 1.

[0091] Table 1

[0092]

[0093]

[0094] Note: Compared with the blank group*(P﹤0.05),**(P﹤0.01)

[0095] Compared with the blank group, the beneficial bacteria in the mice after modeling were significantly reduced and the harmful bacteria were significantly increased, indicating that the modeling was successful.

[0096] The fecal flora counts of mice after administration are shown in Table 2.

[0097] Table 2

[0098] Group / strain Bifidobacterium Lactobacilli Enterococci Enterobacteriaceae Blank group 10.20±0.20## 10.82±0.15## 7.98±0.18## 7.62±0.26## Model Group 7.05±0.18** 6.95±0.09** 11.58±0.20** 12.05±0.12** Positive group 9.55±0.12## 9.70±0.10## 8.05±0.11## 8.12±0.09## Example 1 group 9.08±0.09# 9.10±0.14# 8.56±0.08# 8.64±0.11# Example 2 group 9.12±0.07# 9.15±0.12# 8.60±0.09# 8.66±0.10# Example 3 group 9.27±0.10# 9.18±0.10# 8.64±0.14# 8.71±0.08# Example 4 Group 9.25±0.15# 9.34±0.13# 8.85±0.12# 8.65±0.06# Example 5 Group 9.50±0.07## 9.61±0.05## 8.12±0.07## 8.18±0.13## Comparative Example 1 8.84±0.16# 8.92±0.12# 9.25±0.14# 9.18±0.08# Comparative Example 2 8.80±0.15# 8.95±0.06# 9.51±0.09# 9.42±0.16# Comparative Example 3 9.02±0.10# 9.05±0.08# 9.85±0.12# 9.76±0.14# Comparative Example 4 8.72±0.09# 8.95±0.11# 9.54±0.08# 9.68±0.09# Comparative Example 5 9.01±0.14# 8.99±0.08# 9.14±0.14# 9.21±0.12# Comparative Example 6 9.05±0.10# 9.01±0.05# 9.24±0.06# 9.37±0.07# Comparative Example 7 9.02±0.14# 9.04±0.07# 9.28±0.09# 9.45±0.12#

[0099] Note: Compared with the blank group, *(P﹤0.05), **(P﹤0.01); compared with the model group, #(P﹤0.05), ##(P﹤0.01)

[0100] After administration, compared with the model group, the harmful bacteria in the positive group, Example 1-5 groups and Comparative Example 1-7 groups were significantly reduced, and the beneficial bacteria were significantly increased; especially in Example 5 group, the harmful bacteria decreased most significantly and the beneficial bacteria increased most significantly, indicating that the composition of Example 5 group can effectively promote the growth of beneficial bacteria and inhibit the reproduction of harmful bacteria by reasonably controlling the addition amount of each component.

[0101] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A composition capable of improving intestinal health, characterized in that: The components are as follows in parts by weight: 50-100 parts of oligofructose, 10-50 parts of L-arabinose, 10-50 parts of resistant dextrin, 0.1-5 parts of inulin, 0.1-10 parts of seaweed polysaccharide, 0.01-1 parts of chicken gizzard peptide, 0.01-2 parts of citrus fiber, 0.1-2 parts of beta-glucan, 0.01-1 parts of carrot powder, 0.01-1 parts of spinach powder, 0.01-1 parts of bitter melon powder, 0.01-1 parts of blue mussel oligopeptide, and 0.1-3 parts of isomaltooligosaccharide; The mass ratio of the chicken gizzard peptide, citrus fiber and beta-glucan is 1:1-2:2-10; The mass ratio of the carrot powder, spinach powder and bitter melon powder is 1:1:1; The mass ratio of the seaweed polysaccharide, the blue mussel oligopeptide and the isomaltooligosaccharide is 5-50:1:2-20.

2. The composition capable of improving intestinal health according to claim 1, characterized in that: The components are as follows in parts by weight: 60-90 parts of oligofructose, 15-45 parts of L-arabinose, 20-40 parts of resistant dextrin, 0.2-4 parts of inulin, 0.2-9 parts of seaweed polysaccharide, 0.02-0.9 parts of chicken gizzard peptide, 0.02-1.5 parts of citrus fiber, 0.15-1.9 parts of beta-glucan, 0.02-1 parts of carrot powder, 0.02-1 parts of spinach powder, 0.02-1 parts of bitter melon powder, 0.02-1 parts of blue mussel oligopeptide, 0.05-0.15 parts of blue mussel oligopeptide and 0.1-3 parts of isomaltooligosaccharide.

3. The composition capable of improving intestinal health according to claim 1, characterized in that: The components are as follows in parts by weight: 70-80 parts of oligofructose, 20-30 parts of L-arabinose, 30-40 parts of resistant dextrin, 0.5-1 part of inulin, 0.5-2 parts of seaweed polysaccharide, 0.05-0.3 parts of chicken gizzard peptide, 0.05-0.3 parts of citrus fiber, 0.15-0.4 parts of beta-glucan, 0.02-0.05 parts of carrot powder, 0.02-0.05 parts of spinach powder, 0.02-0.05 parts of bitter melon powder, 0.02-0.05 parts of blue mussel oligopeptide and 0.1-3 parts of isomaltooligosaccharide.

4. The composition capable of improving intestinal health according to claim 1, characterized in that: The invention is composed of the following components by weight: 80 parts of oligofructose, 20 parts of L-arabinose, 30 parts of resistant dextrin, 0.5 parts of inulin, 0.5 parts of seaweed polysaccharide, 0.05 parts of chicken gizzard peptide, 0.05 parts of citrus fiber, 0.15 parts of β-glucan, 0.02 parts of carrot powder, 0.02 parts of spinach powder and 0.02 parts of bitter melon powder, 0.08 parts of blue mussel oligopeptides and 0.5 parts of isomaltooligosaccharide.

5. Use of the composition according to any one of claims 1 to 4 in the preparation of a preparation for improving intestinal health.

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