A method for preparing a low molecular weight heparin sodium lyophilized powder

Abstract

The application relates to the technical field of heparin sodium freeze-dried powder preparation, in particular to a preparation method of low-molecular-weight heparin sodium freeze-dried powder. A base is provided with a conveying mechanism for conveying bottled low-molecular-weight heparin sodium freeze-dried powder, solvent bottles containing physiological saline and packaging boxes; a transmission plate for finished product discharging is arranged on the right side of the base; a displacement mechanism for height adjustment is arranged on the conveying mechanism; a plurality of groups of bottled low-molecular-weight heparin sodium freeze-dried powder or solvent bottles containing physiological saline and a plurality of packaging boxes are intermittently conveyed synchronously through the conveying mechanism; and the bottled low-molecular-weight heparin sodium freeze-dried powder or the solvent bottles containing physiological saline are stacked in the packaging boxes through a stacking mechanism, so that the bottled low-molecular-weight heparin sodium freeze-dried powder and the solvent bottles containing physiological saline can be automatically conveyed and stacked.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of heparin sodium lyophilized powder preparation, in particular to a preparation method of low molecular weight heparin sodium lyophilized powder. BACKGROUND

[0002] Low molecular weight heparin sodium is an anticoagulant drug, which is a modified version of ordinary heparin, has lower molecular weight and better bioavailability, and the low molecular weight heparin sodium in the form of lyophilized powder is a common administration form, which has wide application in deep vein thromboembolism (DVT) prevention and treatment, acute coronary syndrome treatment, stroke prevention, preoperative and postoperative anticoagulant therapy, etc.

[0003] In the use of low molecular weight heparin sodium lyophilized powder, a bottle of low molecular weight heparin sodium lyophilized powder and a bottle of solvent containing physiological saline are usually needed to prepare an injectable heparin solution; the preparation method of low molecular weight heparin sodium lyophilized powder includes raw material dissolution, filtration purification, lyophilized powder production, lyophilized powder collection, quality control, bottle labeling and code packing, wherein the code packing is one of the main steps of code packing of the bottle-packed low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline.

[0004] The existing method is to first code pack the bottle-packed low molecular weight heparin sodium lyophilized powder in the packaging box, and then code pack the solvent bottle containing physiological saline in the packaging box again, which results in low code packing efficiency, and due to clamping, the bottle-packed low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline are not completely clamped in the packaging box, and it is necessary to clamp the bottle-packed low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline again to ensure that the bottle-packed low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline do not fall off from the packaging box in the subsequent process, so that the damage condition occurs. SUMMARY

[0005] Therefore, the present application provides a preparation method of low molecular weight heparin sodium lyophilized powder, which solves the above technical problems.

[0006] The present application provides a preparation method of low molecular weight heparin sodium lyophilized powder, which specifically includes the following steps:

[0007] S1, raw material dissolution: dissolve the low molecular weight heparin sodium raw material in appropriate water or physiological saline, ensure sufficient dissolution, and perform necessary adjustment and control of the solubility to obtain a low molecular weight heparin sodium solution.

[0008] S2, filtration purification: remove impurities and microorganisms in the low molecular weight heparin sodium solution by filtration purification method.

[0009] S3, freeze-dried powder production: the filtered low molecular weight heparin sodium solution is filled into a freeze dryer for freeze-drying treatment, and the water in the low molecular weight heparin sodium solution is directly sublimated into gas at low temperature to obtain low molecular weight heparin sodium freeze-dried powder.

[0010] S4, freeze-dried powder collection: after the freeze-drying operation is completed, the obtained low molecular weight heparin sodium freeze-dried powder is collected.

[0011] S5, quality control: the obtained low molecular weight heparin sodium freeze-dried powder is sampled and quality detected to ensure that the product meets the specified quality standard.

[0012] S6, bottle labeling: the collected low molecular weight heparin sodium freeze-dried powder is bottled and labeled with product information and production batch number.

[0013] S7, box packaging: the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline are box-packaged by an automatic conveying and packaging device.

[0014] The automatic conveying and packaging device involved in the above S7 step comprises a base, a conveying mechanism for conveying the bottled low molecular weight heparin sodium freeze-dried powder, the solvent bottle containing physiological saline and the packaging box is arranged on the upper surface of the base, and a transmission plate for discharging finished products is arranged on the right side of the base.

[0015] A displacement mechanism for adjusting the height is arranged on the conveying mechanism.

[0016] A packaging mechanism for packaging the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline.

[0017] The conveying mechanism comprises a fixed plate fixedly connected to the upper surface of the base, first conveying members are arranged on the front and rear sides of the upper surface of the conveying mechanism, and a second conveying member is arranged at the middle position of the upper surface of the conveying mechanism.

[0018] The first conveying members on the front and rear sides intermittently convey the arranged multiple groups of bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline from left to right, the number of bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline in each group is multiple, the second conveying member intermittently conveys the arranged multiple packaging boxes from left to right, and the multiple groups of bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline on the first conveying member correspond to the multiple packaging boxes on the second conveying member.

[0019] The stacking mechanism comprises a moving piece arranged on a displacement mechanism, two front and rear symmetrical fixed shells are fixedly connected to the moving piece, male pins and female pins are fixedly connected to opposite corners of the two fixed shells, a first pushing piece is arranged on the fixed shell, a plurality of second pushing pieces are arranged on the first pushing piece and inside the fixed shell, an auxiliary piece is arranged inside the fixed shell and below the second pushing pieces, a clamping piece is arranged inside the fixed shell and below the auxiliary piece, and a pressing piece is arranged on the auxiliary piece.

[0020] The clamping piece comprises two symmetrical clamping legs fixedly connected to the inner walls of the front and rear of the fixed shell, two left and right symmetrical limiting blocks are rotatably connected between the opposite surfaces of the two clamping legs, and first spiral springs are arranged between the limiting blocks and the clamping legs.

[0021] The pressing piece comprises a limiting sleeve fixedly connected to the inner wall of the rear side of the fixed shell, a connecting vertical rod is slidably connected to the limiting sleeve, an arc surface plate is fixedly connected to the bottom end of the connecting vertical rod, and a spherical surface block is fixedly connected to the top end of the connecting vertical rod.

[0022] According to the embodiment of the present application, the displacement mechanism comprises two groups of front and rear symmetrical sliding rails fixedly connected to the upper surface of the fixed plate, the number of sliding rails in each group is two, and a first electric sliding block is slidably connected to each of the two sliding rails, and the top ends of the four sliding rails are fixedly connected to a stable frame.

[0023] According to the embodiment of the present application, the first pushing piece comprises a mounting frame fixedly connected to the right side of the fixed shell, two front and rear symmetrical arc surface pushing plates are slidably connected to the mounting frame, the left ends of the two arc surface pushing plates penetrate to the left side of the fixed shell and are slidably connected to the fixed shell, the right ends of the two arc surface pushing plates are fixedly connected to a connecting horizontal plate, an electric telescopic rod is fixedly connected to the mounting frame, and the telescopic end of the electric telescopic rod is fixedly connected to the connecting horizontal plate.

[0024] According to the embodiment of the present application, the second pushing piece comprises a connecting frame fixedly connected to the upper surfaces of the two arc surface pushing plates, a reverse isosceles triangle pushing block is hinged to the inner side of the connecting frame, a limiting baffle is fixedly connected to the left side of the connecting frame, a second spiral spring is arranged between the limiting baffle and the reverse isosceles triangle pushing block, an electromagnet is fixedly connected to the upper surface of the reverse isosceles triangle pushing block, when the lower surface of the electromagnet is in close contact with the upper surface of the connecting frame, the upper surface of the reverse isosceles triangle pushing block is in the same plane as the upper surface of the connecting frame, and the connecting frame is made of metal.

[0025] According to the embodiment of the present application, the moving part comprises four first electric sliding blocks fixedly connected with a rectangular track frame, two front and back symmetrical second electric sliding blocks are slidably connected to the left and right sides of the rectangular track frame, and a fixing shell is fixedly connected between the opposite sides of the two second electric sliding blocks.

[0026] According to the embodiment of the present application, the auxiliary part is a sector block arranged inside the fixing shell, mounting grooves are formed on the front and back surfaces of the sector block, limiting columns are fixedly connected inside the mounting grooves, limiting connecting plates are slidably connected to the circumferential surface of the limiting columns, the limiting connecting plates are slidably connected with the mounting grooves, one end of the limiting connecting plates away from the sector block is fixedly connected with the inner wall of the fixing shell, and the sector block is slidably connected with the corresponding connecting vertical rods.

[0027] According to the embodiment of the present application, the connecting vertical rods and the limiting sleeves are in damping fit, and the friction between the connecting vertical rods and the limiting sleeves is greater than the friction between the connecting vertical rods and the sector block.

[0028] According to the embodiment of the present application, the bottom end of one side of the limiting block towards the center of the clamping leg is arc-shaped, the bottom end of the limiting block is wrapped with rubber, and the number of the clamping parts corresponds to the number of a group of lyophilized powder and physiological saline conveyed by the first conveying part.

[0029] The technical scheme of the present application has the following beneficial effects: 1. The conveying mechanism is used to synchronously and intermittently convey a plurality of groups of bottled low molecular weight heparin sodium lyophilized powder and solvent bottles containing physiological saline and a plurality of packaging boxes, and the stacking mechanism is used to stack the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline inside the packaging boxes, so that the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline are automatically conveyed and stacked, and the packaging efficiency of the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline is improved.

[0030] 2. After the second pushing part cooperates with the pressing part to place the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline inside the packaging boxes, the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline are clamped inside the packaging boxes, so that the stability of the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline after stacking can be ensured, and the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline will not fall off from the inside of the packaging boxes in the subsequent process, so that the damage of the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottles containing physiological saline can be avoided. BRIEF DESCRIPTION OF DRAWINGS

[0031] In order to make the technical solutions in the embodiments of the present application or the prior art clearer, the accompanying drawings needed in the embodiments or prior art description will be briefly introduced. Obviously, the accompanying drawings in the following description only aim at the embodiments of the present application, and other drawings can be obtained by those skilled in the art without any creative effort on the basis of the provided drawings.

[0032] Figure 1 is a flow chart of the preparation method of the low molecular weight heparin sodium lyophilized powder provided by the present application.

[0033] Figure 2 is a perspective structural schematic diagram of the automatic conveying and stacking device involved in the preparation method of the low molecular weight heparin sodium lyophilized powder provided by the present application.

[0034] Figure 3 is a perspective structural schematic diagram of the conveying mechanism provided by the present application.

[0035] Figure 4 is a perspective structural schematic diagram of the displacement mechanism provided by the present application.

[0036] Figure 5 is a perspective structural schematic diagram of the Figure 4 enlarged view of part A in

[0037] Figure 6 is a perspective structural schematic diagram of the stacking mechanism provided by the present application.

[0038] Figure 7 is a perspective structural schematic diagram of the first pushing piece, the second pushing piece and the clamping piece provided by the present application.

[0039] Figure 8 is a perspective structural schematic diagram of the Figure 7 front view of

[0040] Figure 9 is a dynamic schematic diagram of the mutual cooperation of the rest structures in the motion process of the cambered surface pushing plate structure provided by the present application.

[0041] Reference signs:

[0042] 1, base; 2, conveying mechanism; 3, stacking mechanism; 4, displacement mechanism; 5, transmission plate; 21, first conveying piece; 22, fixed plate; 23, second conveying piece; 31, fixed shell; 32, female pin; 33, first pushing piece; 34, second pushing piece; 35, moving piece; 36, male pin; 37, clamping piece; 38, auxiliary piece; 39, pressing piece; 41, stable frame; 42, sliding rail; 43, first electric sliding block; 331, arc pushing plate; 332, mounting frame; 333, connecting horizontal plate; 334, electric telescopic rod; 341, limiting baffle; 342, electromagnet; 343, connecting frame; 344, inverted isosceles triangle pushing block; 351, rectangular rail frame; 352, second electric sliding block; 371, clamping leg; 372, limiting block; 381, fan-shaped block; 382, limiting connecting plate; 383, limiting column; 384, mounting sliding groove; 391, connecting vertical rod; 392, limiting sleeve; 393, arc plate; 394, spherical block. DETAILED DESCRIPTION

[0043] In order to make the above objectives, features and advantages of the present application more obvious and easy to understand, the specific embodiments of the present application are described in detail below with reference to the drawings. In the following description, a large number of specific details are set forth in order to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the spirit of the present application, so the present application is not limited to the specific embodiments disclosed below.

[0044] As shown in Figure 1 and Figure 2 , a preparation method of a low molecular weight heparin sodium freeze-dried powder, specifically comprising the following steps:

[0045] S1, dissolving raw materials: dissolving low molecular weight heparin sodium raw materials in appropriate water or physiological saline, ensuring sufficient dissolution, and performing necessary adjustment and control of solubility to obtain a low molecular weight heparin sodium solution.

[0046] S2, filtration and purification: removing impurities and microorganisms in the low molecular weight heparin sodium solution by filtration and purification method.

[0047] S3, freeze-dried powder making: filling the filtered and purified low molecular weight heparin sodium solution into a freeze dryer for freeze-drying treatment, directly sublimating the water in the low molecular weight heparin sodium solution into gas at low temperature to obtain low molecular weight heparin sodium freeze-dried powder.

[0048] S4, freeze-dried powder collection: after completing the freeze-drying operation, the obtained low molecular weight heparin sodium freeze-dried powder is collected.

[0049] S5, quality control: sampling and quality testing of the obtained low molecular weight heparin sodium freeze-dried powder to ensure that the product meets the specified quality standards.

[0050] S6, bottle identification; the collected low molecular weight heparin sodium freeze-dried powder is bottled, and product information and production batch number are marked.

[0051] S7, box packaging: the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline are box-packaged by an automatic conveying and packing device.

[0052] The automatic conveying and packing device involved in the above S7 step comprises a base 1, the upper surface of the base 1 is provided with a conveying mechanism 2 for conveying the bottled low molecular weight heparin sodium freeze-dried powder, the solvent bottle containing physiological saline and the packaging box, and the right side of the base 1 is provided with a conveying plate 5 for discharging finished products.

[0053] A displacement mechanism 4 for adjusting the height is arranged on the conveying mechanism 2.

[0054] A packing mechanism 3 for packing the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline.

[0055] As shown in Figure 3 , the conveying mechanism 2 comprises a fixed plate 22 fixedly connected to the upper surface of the base 1, the upper surface of the conveying mechanism 2 is provided with first conveying members 21 on the front and back sides, and the upper surface of the conveying mechanism 2 is provided with a second conveying member 23 at the middle position, the first conveying members 21 on the front and back sides intermittently convey a plurality of groups of the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline arranged from left to right, respectively, the number of the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline in each group is a plurality, the second conveying member 23 intermittently conveys a plurality of packaging boxes arranged from left to right, and the plurality of groups of the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline on the first conveying members 21 correspond to the plurality of packaging boxes on the second conveying member 23.

[0056] As shown in Figure 5 and Figure 6 , the packing mechanism 3 comprises a moving member 35 arranged on the displacement mechanism 4, the moving member 35 is fixedly connected with two front and back symmetrical fixed shells 31, the opposite faces of the two fixed shells 31 are respectively fixedly connected with a male pin 36 and a female pin 32, the fixed shell 31 is provided with a first pushing member 33, the first pushing member 33 is provided with a plurality of uniformly distributed second pushing members 34 on the inside of the fixed shell 31, the inside of the fixed shell 31 and below the second pushing members 34 is provided with an auxiliary member 38, the inside of the fixed shell 31 and below the auxiliary member 38 is provided with a clamping member 37, and the auxiliary member 38 is provided with a pressing member 39.

[0057] As shown in Figure 4As shown, the displacement mechanism 4 includes two groups of front and rear symmetrical sliding rails 42 fixedly connected to the upper surface of the fixed plate 22, each group of sliding rails 42 has two and a first electric sliding block 43 is slidably connected to the upper and lower surfaces of each group of sliding rails 42, and the top ends of the four sliding rails 42 are fixedly connected to a stable frame 41.

[0058] In specific use, the first conveying members 21 on the front and rear sides intermittently convey the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline from left to right, respectively, and the second conveying member 23 intermittently conveys the packaging box from left to right, and when the bottled low molecular weight heparin sodium lyophilized powder, the solvent bottle containing physiological saline, and the packaging box move to the lower side of the fixed shell 31, conveying is stopped at this time, the first electric sliding block 43 is moved downward on the sliding rail 42, the front and rear two fixed shells 31 are simultaneously pushed downward and are attached to the upper surfaces of the front and rear two first conveying members 21, and the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline are covered inside.

[0059] At this time, the inside of the fixed shell 31 on the front side is the bottled low molecular weight heparin sodium lyophilized powder, and the inside of the fixed shell 31 on the rear side is the solvent bottle containing physiological saline, and then the first pushing member 33 cooperates with the auxiliary member 38 to push the clamping member 37 to clamp the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline inside the fixed shell 31, and when clamping is completed, the first electric sliding block 43 is restored to the original position, the two fixed shells 31 are synchronously moved to the upper side of the packaging box by the moving member 35, at this time, the male pin 36 and the female pin 32 on the opposite surfaces of the two fixed shells 31 are cooperatively clamped together, so that the two fixed shells 31 are connected to each other, and the two fixed shells 31 are synchronously moved downward.

[0060] At this time, the first electric sliding block 43 is moved downward again to the lower surface of the fixed shell 31, which is attached to the inner wall of the bottom end of the packaging box, and then the clamping member 37 cancels the limiting of the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline, at this time, the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline fall above the clamping groove of the packaging box, and the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline are again subjected to downward pushing force by the pressing member 39 to be clamped firmly in the clamping groove inside the packaging box, and then the fixed shell 31 and the first electric sliding block 43 are restored to the original position, completing the stacking of the bottled low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline.

[0061] As Figure 7 and Figure 8As shown, the first pusher 33 comprises a mounting frame 332 fixedly connected to the right side of the fixed shell 31. Two front and rear symmetrical arc push plates 331 are slidingly connected to the mounting frame 332. The left end of the arc push plate 331 penetrates through the left side of the fixed shell 31 and is slidingly connected with the fixed shell 31. The right ends of the two arc push plates 331 are fixedly connected with a connecting plate 333. An electric telescopic rod 334 is fixedly connected to the mounting frame 332, and the telescopic end of the electric telescopic rod 334 is fixedly connected with the connecting plate 333.

[0062] As shown in Figure 7 and Figure 8 As shown, the second pusher 34 comprises a connecting frame 343 fixedly connected to the upper surfaces of the two arc push plates 331. A reverse isosceles triangle push block 344 is hingedly connected to the inner side of the connecting frame 343. A limiting baffle 341 is fixedly connected to the left side of the connecting frame 343. A second volute spring (not shown in the figure) is arranged between the limiting baffle 341 and the reverse isosceles triangle push block 344. An electromagnet 342 is fixedly connected to the upper surface of the reverse isosceles triangle push block 344. When the lower surface of the electromagnet 342 is in close contact with the upper surface of the connecting frame 343, the upper surface of the reverse isosceles triangle push block 344 is in the same plane as the upper surface of the connecting frame 343. The connecting frame 343 is made of metal.

[0063] As shown in Figure 7 and Figure 8 As shown, the moving part 35 comprises a rectangular track frame 351 to which four first electric sliding blocks 43 are fixedly connected. Two front and rear symmetrical second electric sliding blocks 352 are slidingly connected to the left and right sides of the rectangular track frame 351. The fixed shell 31 is fixedly connected between the opposite faces of the two second electric sliding blocks 352 arranged on the left and right.

[0064] As shown in Figure 7 and Figure 8 As shown, the clamping part 37 comprises two symmetrical clamping legs 371 fixedly connected to the front and rear inner walls of the fixed shell 31. Two left and right symmetrical limiting blocks 372 are rotatably connected between the opposite faces of the two clamping legs 371. A first volute spring (not shown in the figure) is arranged between the limiting block 372 and the clamping leg 371. The bottom end of the face of the limiting block 372 towards the center of the clamping leg 371 is arc-shaped. The bottom end of the limiting block 372 is wrapped with rubber. The number of the clamping part 37 corresponds to the number of a group of lyophilized powder and physiological saline conveyed by the first conveying part 21.

[0065] As shown in Figure 7 and Figure 8As shown, the auxiliary part 38 is arranged in the sector block 381 inside the fixed shell 31, the front and rear surfaces of the sector block 381 are provided with mounting sliding grooves 384, the inside of the mounting sliding grooves 384 is fixedly connected with the limiting columns 383 arranged in the up and down direction, the circumferential surface of the limiting columns 383 is slidably connected with the limiting connecting plates 382, the limiting connecting plates 382 are slidably connected with the mounting sliding grooves 384, and the end of the limiting connecting plates 382 away from the sector block 381 is fixedly connected with the inner wall of the fixed shell 31.

[0066] In specific use, when starting to clamp the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline, after the lower surface of the fixed shell 31 is attached to the upper surface of the first conveying part 21, a plurality of bottled low molecular weight heparin sodium freeze-dried powder and solvent bottles containing physiological saline are respectively arranged between the opposite surfaces of the two left and right symmetrical limiting blocks 372 between the two clamping legs 371 arranged in front and back, and then the arc-shaped pushing plate 331 is pushed to move leftwards on the fixed shell 31 through the extension of the electric telescopic rod 334. At this time, the arc surface of the lower surface of the arc-shaped pushing plate 331 gradually approaches the upper surface of the sector block 381, and when the arc surface of the lower surface of the arc-shaped pushing plate 331 contacts the upper surface of the sector block 381, a downward pushing force is generated on the sector block 381 as the arc-shaped pushing plate 331 continues to move leftwards.

[0067] At this time, the sector block 381 drives the limiting columns 383 to slide downwards on the limiting connecting plates 382, and as the sector block 381 slides downwards, the left and right inclined surfaces of the sector block 381 gradually contact the top ends of the limiting blocks 372. When the left and right inclined surfaces of the sector block 381 contact the top ends of the limiting blocks 372 and continue to slide downwards, the sector block 381 pushes the top ends of the two limiting blocks 372 to move in opposite directions on the clamping legs 371, and at this time, the bottom ends of the two limiting blocks 372 move in the same direction to clamp the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline between the two limiting blocks 372. The rubber wrapped around the bottom ends of the limiting blocks 372 can prevent damage to the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline during clamping, and can also clamp the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline more stably.

[0068] As shown in Figure 7 , Figure 8 and Figure 9 , the pressing part 39 includes the limiting sleeve 392 fixedly connected to the inner wall of the rear side of the fixed shell 31, the connecting vertical rod 391 slidably connected to the limiting sleeve 392 in the up and down direction, the arc-shaped plate 393 fixedly connected to the bottom end of the connecting vertical rod 391, the spherical block 394 fixedly connected to the top end of the connecting vertical rod 391, and the sector block 381 slidably connected to the corresponding connecting vertical rod 391 in the up and down direction.

[0069] In specific use, when the bottle of low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline are clamped, at this time the inverted isosceles triangle push block 344 is located at the right side of the spherical block 394 (as shown in the top of the middle of the figure), when the arc push plate 331 moves to the left, the inverted isosceles triangle push block 344 moves synchronously, when the inverted isosceles triangle push block 344 passes the spherical block 394, at this time the inclined surface at the left side of the inverted isosceles triangle push block 344 is in contact with the spherical block 394, the spherical block 394 generates resistance to the inverted isosceles triangle push block 344, with the continuous movement of the arc push plate 331, at this time the electromagnet 342 is not electrified, there is no attraction force to the connecting frame 343, the spherical block 394 pushes the inverted isosceles triangle push block 344 to rotate on the connecting frame 343, the inverted isosceles triangle push block 344 is inclined to the right and upward on the connecting frame 343 (as shown in the middle of the middle of the figure), under the action of the limiting baffle 341, the inverted isosceles triangle push block 344 can be prevented from being deflected too much to the left, at this time with the continuous movement of the arc push plate 331, when the inverted isosceles triangle push block 344 moves to the left side of the spherical block 394, and the inclined surface at the right side of the inverted isosceles triangle push block 344 is not in contact with the spherical block 394, the inverted isosceles triangle push block 344 is restored to the original position on the connecting frame 343 under the elastic force of the first spiral spring itself (as shown in the middle of the bottom of the figure), and through the limiting of the electromagnet 342, the inverted isosceles triangle push block 344 can be prevented from being deflected too much downward on the connecting frame 343, at the same time, the inverted isosceles triangle push block 344 is kept stable on the connecting frame 343. Figure 9 Figure 9 Figure 9

[0070] When the electric telescopic rod 334 drives the arc push plate 331 to return to the original position, at this time the inclined surface at the right side of the inverted isosceles triangle push block 344 is in contact with the spherical block 394, at the same time the electromagnet 342 is electrified to attract the inverted isosceles triangle push block 344 to the connecting frame 343, through the inclined downward thrust of the inverted isosceles triangle push block 344 to the spherical block 394, the spherical block 394 is pushed to move downward, the connecting vertical rod 391 moves synchronously downward, at this time the limiting block 372 has cancelled the clamping of the bottle of low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline, with the downward movement of the connecting vertical rod 391, the connecting vertical rod 391 pushes the bottle of low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline below the arc plate 393 to move downward synchronously, and pushes the bottle of low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline to the inside of the clamping groove inside the packaging box, and clamps the bottle of low molecular weight heparin sodium lyophilized powder and the solvent bottle containing physiological saline firmly in the clamping groove inside the packaging box.

[0071] ​​​Working principle: in specific use, the first conveying member 21 on the front and back sides respectively from left to right intermittent conveying bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle, the second conveying member 23 from left to right intermittent conveying packaging box, when bottled low molecular weight heparin sodium freeze-dried powder, containing physiological saline solvent bottle and packaging box moves to the lower of fixed shell 31, at this time stop conveying, through the first electric sliding block 43 on the sliding rail 42 moves down to the limit bar position, at this time the fixed shell 31 is pushed down and fits on the upper surface of the first conveying member 21, through the electric telescopic rod 334 pushes the arc surface push plate 331 to move left, the arc surface push plate 331 pushes the sector block 381 to move down, the sector block 381 pushes the top of the two limit blocks 372 on the clamping leg 371 to move away from the clamping leg 371, at this time the limit block 372 rotates on the clamping leg 371, the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle below the bottom of the limit block 372 are clamped.

[0072] At this time the first electric sliding block 43 is restored to the original position, then the fixed shell 31 is moved to the upper of the packaging box by moving the rectangular rail frame 351 on the second electric sliding block 352 forward and backward, at this time the fixed shell 31 is moved down to the inner wall of the bottom of the packaging box by the first electric sliding block 43 again, then the arc surface push plate 331 is restored to the original position, at this time the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle fall in the inside of the packaging box, in the process of restoring the arc surface push plate 331 to the original position, the sector block 381 is pushed down by the inverted isosceles triangle push block 344, which produces a downward thrust on the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle, and pushes the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle into the clamping groove inside the packaging box.

[0073] At this time the first electric sliding block 43 is restored to the original position, then the fixed shell 31 is moved to the upper of the packaging box by moving the rectangular rail frame 351 on the second electric sliding block 352 forward and backward, at this time the fixed shell 31 is moved down to the inner wall of the bottom of the packaging box by the first electric sliding block 43 again, then the arc surface push plate 331 is restored to the original position, at this time the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle fall in the inside of the packaging box, in the process of restoring the arc surface push plate 331 to the original position, the sector block 381 is pushed down by the inverted isosceles triangle push block 344, which produces a downward thrust on the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle, and pushes the bottled low molecular weight heparin sodium freeze-dried powder and containing physiological saline solvent bottle into the clamping groove inside the packaging box.

[0074] In the description of the present application, it is to be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "back", "left", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like is based on the orientation or positional relationship shown in the drawings, and is only for the purpose of facilitating the description of the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation of the present application.

[0075] In addition, the terms "first", "second", "one", "two" are only for the purpose of description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined with "first", "second", "one", "two" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "a plurality of" is at least two, for example, two, three, etc., unless otherwise explicitly specified and limited.

[0076] In the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting", "fixing" and the like should be understood in a broad sense, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanically connected, or it can be electrically connected; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements, unless otherwise explicitly limited. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0077] The embodiments of the present specific embodiment are the preferred embodiments of the present application, and are not limited to the protection scope of the present application, therefore: any equivalent changes made according to the structure, shape, principle of the present application should be covered within the protection scope of the present application.

Claims

1. A process for the preparation of a lyophilized powder of low molecular weight heparin sodium, characterized in that: Specifically comprising the following steps: S1, raw material dissolution: the low molecular weight heparin sodium raw material is dissolved in appropriate water or physiological saline, ensuring sufficient dissolution, and adjusting and controlling the solubility to obtain a low molecular weight heparin sodium solution; S2, filtration and purification: removing impurities and microorganisms in the low molecular weight heparin sodium solution by filtration and purification method; S3, freeze-dried powder making: filling the filtered and purified low molecular weight heparin sodium solution into a freeze dryer for freeze-drying treatment, directly sublimating the water in the low molecular weight heparin sodium solution into gas at low temperature to obtain low molecular weight heparin sodium freeze-dried powder; S4, freeze-dried powder collection: after completing the freeze-drying operation, the obtained low molecular weight heparin sodium freeze-dried powder is collected; S5, quality control: sampling quality detection is performed on the obtained low molecular weight heparin sodium freeze-dried powder to ensure that the product meets the specified quality standard; S6, bottling and labeling: the collected low molecular weight heparin sodium freeze-dried powder is bottled and labeled with product information and production batch number; S7, boxing: the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline are boxed by an automatic conveying and boxing device; The automatic conveying and boxing device involved in the above S7 step comprises a base, a conveying mechanism for conveying the bottled low molecular weight heparin sodium freeze-dried powder, the solvent bottle containing physiological saline and the packaging box is arranged on the upper surface of the base, and a transmission plate for discharging finished products is arranged on the right side of the base; A displacement mechanism for adjusting the height is arranged on the conveying mechanism; A boxing mechanism for boxing the bottled low molecular weight heparin sodium freeze-dried powder and the solvent bottle containing physiological saline; The conveying mechanism comprises a fixed plate fixedly connected to the upper surface of the base, first conveying members are arranged on the front and rear sides of the upper surface of the conveying mechanism, and a second conveying member is arranged at the middle position of the upper surface of the conveying mechanism; The boxing mechanism comprises a moving member arranged on the displacement mechanism, two front and rear symmetrical fixed shells are fixedly connected to the moving member, male pins and female pins are fixedly connected to the opposite corners of the two fixed shells, a first pushing member is arranged on the fixed shell, a plurality of second pushing members are uniformly distributed on the first pushing member and located inside the fixed shell, an auxiliary member is arranged inside the fixed shell and below the second pushing member, a clamping member is arranged inside the fixed shell and below the auxiliary member, and a pressing member is arranged on the auxiliary member; The pressing member comprises a limiting sleeve fixedly connected to the inner wall of the rear side of the fixed shell, a connecting vertical rod is slidably connected to the limiting sleeve, an arc surface plate is fixedly connected to the bottom end of the connecting vertical rod, and a spherical surface block is fixedly connected to the top end of the connecting vertical rod; The first pushing member comprises a mounting bracket fixedly connected to the right side of the fixed shell, two front and rear symmetrical arc surface pushing plates are slidably connected to the mounting bracket, the left ends of the arc surface pushing plates penetrate through the left side of the fixed shell and are slidably connected with the fixed shell, a connecting horizontal plate is fixedly connected to the right ends of the two arc surface pushing plates, an electric telescopic rod is fixedly connected to the mounting bracket, and the telescopic end of the electric telescopic rod is fixedly connected with the connecting horizontal plate; The second pushing piece comprises a connecting frame fixedly connected to the upper surfaces of two arc pushing plates, an inverted isosceles triangle pushing block hinged to the inner side of the connecting frame, a limiting baffle fixedly connected to the left side of the connecting frame, a second volute spring arranged between the limiting baffle and the inverted isosceles triangle pushing block, an electromagnet fixedly connected to the upper surface of the inverted isosceles triangle pushing block, and the lower surface of the electromagnet is attached to the upper surface of the connecting frame, so that the upper surface of the inverted isosceles triangle pushing block is in the same plane as the upper surface of the connecting frame, and the connecting frame is made of metal; The auxiliary part is a sector block arranged inside the fixed shell, mounting grooves are formed in the front and rear surfaces of the sector block, limiting columns are fixedly connected to the mounting grooves in an up-down arrangement, limiting connecting plates are slidably connected to the circumferential surface of the limiting columns, the limiting connecting plates are slidably connected to the mounting grooves, the end of the limiting connecting plates away from the sector block is fixedly connected to the inner wall of the fixed shell, and the sector block is slidably connected to the corresponding connecting vertical rod in an up-down arrangement.

2. A process for the preparation of a lyophilized powder of low molecular weight heparin sodium as claimed in claim 1, wherein: The displacement mechanism comprises two groups of front-rear symmetrical sliding tracks fixedly connected to the upper surface of the fixed plate, each group of the sliding tracks comprises two sliding tracks, and a first electric sliding block is slidably connected to each sliding track in an up-down arrangement.

3. A process for the preparation of a lyophilized powder of low molecular weight heparin sodium as claimed in claim 2, wherein: The moving part comprises a rectangular track frame fixedly connected to the four first electric sliding blocks, two front-rear symmetrical second electric sliding blocks are slidably connected to the left and right sides of the rectangular track frame, and a fixed shell is fixedly connected between the opposite surfaces of the two second electric sliding blocks arranged in a left-right arrangement.

4. A process for the preparation of a lyophilized powder of low molecular weight heparin sodium as claimed in claim 1, wherein: The connecting vertical rod and the limiting sleeve are in damping fit, and the friction force between the connecting vertical rod and the limiting sleeve is greater than the friction force between the connecting vertical rod and the sector block.

5. A process for the preparation of a lyophilized powder of low molecular weight heparin sodium as claimed in claim 1, wherein: The clamping part comprises two symmetrical clamping legs fixedly connected to the front and rear inner walls of the fixed shell, two left-right symmetrical limiting blocks are rotatably connected between the opposite surfaces of the two clamping legs, a first volute spring is arranged between the limiting block and the clamping leg, the bottom end of the surface of the limiting block facing the center of the clamping leg is arc-shaped, the bottom end of the limiting block is wrapped with rubber, and the number of the clamping parts corresponds to the number of a group of freeze-dried powder and physiological saline conveyed by the first conveying part.

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