Space spraying insecticide composition containing piperic acid derivative compounds

Abstract

The invention discloses a space spraying insecticide composition containing piperic acid derivative compounds, which is composed of active ingredients A and B, wherein A is a piperic acid derivative compound, and B is tetrafluthrin, tetrafluthrin, methifluthrin, D-trans-chlorprophthrin, tetrafluthrin, D-phenothrin, sepfluthrin, D-sepfluthrin, bio-allethrin, chlorfenthrin, sepfluthrin or D-trans-allethrin-rich; the total weight of A and B accounts for 0.2% to 30% of the insecticide composition; the weight ratio of A to B is 20:1 to 1:1. The invention has the characteristics of high efficiency and low toxicity, can be used as a space spraying agent, has a quick effect, kills thoroughly, reduces the amount of medicine applied, and reduces the irritation of medicine application. As a lethal agent, the piperic acid derivative compounds have no cross-resistance and good lethal effect, are widely used in hotels, schools, factories, homes and public places, and have special effects on preventing and controlling sanitary pests.

Description

Technical Field

[0001] The invention relates to a space spraying insecticide composition containing a piperic acid derivative compound. The effective ingredients of the composition are the piperic acid derivative compound and pyrethroids. The pyrethroids include any one of cypermethrin, tetrafluthrin, methicillin, D-trans-chlorpropthrin, transfluthrin, phenothrin, sepfluthrin, D-sepfluthrin, bio-allethrin, chlorfenapyr, D-allethrin and D-trans-allethrin-enriched. Background Art

[0002] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has contact and stomach poison activity and good conduction activity, and can be used to control a variety of Lepidoptera, Hemiptera, Thysanoptera, Coleoptera and other pests.

[0003]

[0004] The structural formula of the compound is as follows:

[0005] Pyrethroids for sanitary use have stomach poison, contact killing and fumigation effects. They are a good knockdown agent and lethal agent and are widely used in the field of sanitary medicine, such as mosquito coils, aerosols, liquid mosquito coils, etc. They are suitable for space spraying in sanitary outdoor environments.

[0006] At present, sanitary pests have a high resistance to pyrethroids, and it is easy for pests to revive after being knocked down. To address this dilemma, we considered compounding a piperic acid derivative compound with pyrethroids. On the one hand, the two have different mechanisms of action, and there is no cross-resistance in the combination, which can solve the problem of sanitary pests' resistance to pyrethroids and reduce the amount of pesticides applied. On the other hand, the piperic acid derivative compound has low irritation, which improves the safety of pesticide applicators. Furthermore, through research, it was found that the combination of the two can improve the control effect of sanitary pests, and it is a combination drug application technology with good market prospects.

[0007] At the same time, conventional space sprays only have a rapid killing effect and have almost no lasting effect. To increase the lasting effect, high molecular surfactants or high molecular wrapping materials are often added to the preparation. However, this will cause the droplet particle size to become larger, causing the droplets to settle too quickly. At the same time, the original drug is wrapped, which affects the release of the active ingredients, and ultimately leads to a decrease in rapid effectiveness. Through research, we have found that the addition of some special solvents can increase the adhesion properties of the droplets, thereby increasing the lasting effect without affecting the droplet particle size. Summary of the invention

[0008] The technical problem to be solved by the present invention is to provide a space spraying insecticide composition containing piperic acid derivative compounds in view of the deficiencies in the prior art. The composition of the present invention compounds piperic acid derivative compounds with pyrethroids, has good insecticidal effect, low drug cost, and has synergistic effect and is not easy to produce drug resistance. In addition, a persistent agent component is added to increase the persistent performance.

[0009] In order to achieve the above object, the present invention adopts the following technical solution:

[0010] The present invention first provides a space spraying insecticide composition containing a piperic acid derivative compound, wherein the active ingredients consist of an active ingredient A and an active ingredient B, wherein the total weight of the active ingredient A and the active ingredient B accounts for 0.2% to 30% of the insecticide composition, and the remainder is an auxiliary material;

[0011] The active ingredient A is a piperic acid derivative compound represented by formula I (referred to as compound I-72);

[0012] The active ingredient B is selected from any one of cypermethrin, tetrafluthrin, methoxyfluthrin, d-trans chlorpropthrin, cypermethrin, d-phenothrin, sepfluthrin, d-sepfluthrin, bio-allethrin, chlorfenthrin, d-allethrin, and d-trans allethrin;

[0013]

[0014] In the above technical solution, the weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:1, wherein:

[0015] The weight ratio of the piperic acid derivative compound (I-72) to tetrafluthrin is preferably 10:1 to 2:1;

[0016] The weight ratio of the piperic acid derivative compound (I-72) to tetrafluthrin is preferably 10:1 to 5:1;

[0017] The weight ratio of the piperic acid derivative compound (I-72) to metofluthrin is preferably 20:1 to 2:1;

[0018] The weight ratio of the piperic acid derivative compound (I-72) to D-trans-chlorpromazine is preferably 10:1 to 1:1;

[0019] The weight ratio of the piperic acid derivative compound (I-72) to transfluthrin is preferably 8:1 to 1:1;

[0020] The weight ratio of the piperic acid derivative compound (I-72) to d-phenothrin is preferably 4:1 to 1:1;

[0021] The weight ratio of the piperic acid derivative compound (I-72) to tefluthrin is preferably 8:1 to 1:1;

[0022] The weight ratio of the piperic acid derivative compound (I-72) to dexamethasone is preferably 10:1 to 5:1;

[0023] The weight ratio of the piperic acid derivative compound (I-72) to chlorpyrifos is preferably 10:1 to 4:1;

[0024] The weight ratio of the piperic acid derivative compound (I-72) to bio-allethrin is preferably 8:1 to 2:1;

[0025] The weight ratio of the piperic acid derivative compound (I-72) to allethrin is preferably 8:1 to 2:1;

[0026] The weight ratio of the piperic acid derivative compound (I-72) to the right-handed trans-allylthrin is preferably 8:1 to 2:1.

[0027] In the above technical scheme, the insecticide composition is in the form of emulsifiable concentrate, water emulsion, microemulsion, soluble liquid, thermal fog agent or suspoemulsion, and the auxiliary material can be any one of solvent, emulsifier, dispersant, wetting agent, defoaming agent, antifreeze agent, preservative, thickener, persistence promoter, water, or a mixture of two or more in any proportion.

[0028] In the above technical scheme, the insecticide composition, when in the form of emulsifiable concentrate, comprises 1%-10% active ingredient A, 0.1%-5% active ingredient B, 8%-20% emulsifier, 10%-40% persistent agent, and the solvent is supplemented to 100%.

[0029] In the above technical scheme, the insecticide composition, when in the form of an aqueous emulsion, comprises 1%-10% active ingredient A, 0.1%-5% active ingredient B, 5%-20% solvent, 2%-15% effective promoter, 8%-15% emulsifier, 1%-5% antifreeze agent, 0.1%-0.5% defoaming agent, and water is supplemented to 100%.

[0030] In the above technical scheme, the insecticide composition, when in the form of a microemulsion, comprises 1%-10% active ingredient A, 0.1%-5% active ingredient B, 15%-30% emulsifier, 10%-30% solvent, 2%-10% persistent agent, and water is supplemented to 100%.

[0031] In the above technical scheme, the insecticide composition, when in the form of a soluble liquid, comprises 1%-10% active ingredient A, 1%-10% active ingredient B, 15%-30% emulsifier, 10%-30% persistent agent, and the solvent is supplemented to 100%.

[0032] In the above technical solution, the insecticide composition, when in the form of a thermal fog agent, comprises 0.1%-2% active ingredient A, 0.1%-2% active ingredient B, 30%-50% prolonging agent, and the solvent is supplemented to 100%.

[0033] In the above technical scheme, the insecticide composition, when in the form of a suspoemulsion, comprises 5%-25% active ingredient A, 1%-5% active ingredient B, 1%-3% emulsifier, 2%-8% dispersant, 1%-5% wetting agent, 5%-10% solvent, 0.1%-3% thickener, 0.1%-2% preservative, 1%-5% antifreeze, and water is supplemented to 100%.

[0034] In the above scheme, the solvent is selected from: one or more of trimethylbenzene, tetramethylbenzene, pentamethylbenzene, ethanol, cyclohexanone, odorless kerosene, N,N-dimethylacetamide, N,N-dimethylpropionamide, N,N-dimethylhexylamide, N-methylpyrrolidone, diisopropyl adipate, tributyl citrate, acetyl tributyl citrate, ethylene glycol methyl ether, piperonyl butoxide, and dodecylbenzene.

[0035] In the above technical scheme, the emulsifier is selected from: styrylphenol polyoxyethylene ether (such as Nongru 600# series), calcium dodecylbenzene sulfonate (such as Nongru 500# of Nanjing Taihua Co., Ltd.), OP series phosphate (alkylphenol polyoxyethylene ether phosphate), phenylphenol polyoxyethyl ether phosphate (such as Jiangsu Kaiyuan 600# phosphate), styrene polyoxyethylene ether ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salt, triethanolamine salt, benzyl dimethylphenol polyoxyethyl ether (such as Nongru 400#), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethyl ether), One or more of phenylethylphenol polyoxyethyl polypropylene ether (such as Nongru 1600#), ethylene oxide-propylene oxide block copolymer, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether (such as Jiangsu Kaiyuan's EL series), alkylaryl polyoxypropylene polyoxyethylene ether (such as Nanjing Taihua's Nongru 33#), alkylaryl polyoxyethylene polyoxypropylene ether (such as Nanjing Taihua's Nongru 34#), Span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether), fatty alcohol polyoxyethylene ether (such as Hai'an Petrochemical MOA series).

[0036] In the above scheme, the dispersant is selected from: one or more of: sodium salt of polycarboxylate, sodium salt of lignin sulfonate, sulfate of alkylphenol polyoxyethylene ether formaldehyde condensate, calcium salt of alkylbenzene sulfonate, sodium salt of naphthalenesulfonic acid formaldehyde condensate, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, and glycerol fatty acid ester polyoxyethylene ether.

[0037] In the above scheme, the wetting agent is selected from: one or more of alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, sodium alkyl sulfonate, naphthalene sulfonate (such as NNO), sodium dodecyl sulfate, opening powder BX, wetting penetrant F, and sodium dodecylbenzene sulfonate.

[0038] In the above scheme, the defoaming agent can be one or more of silicone oil, polydimethylsiloxane, C8-10 fatty alcohol compounds, and C10-20 saturated fatty acid compounds.

[0039] In the above scheme, the antifreeze agent can be one or more of ethylene glycol, propylene glycol, glycerol, and urea.

[0040] In the above scheme, the preservative is selected from one or more of potassium sorbate and sodium benzoate.

[0041] In the above scheme, the thickener is selected from: one or more of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, and white carbon black.

[0042] In the above scheme, the effect-promoting agent can be any one of propylene glycol phenyl ether, dipropylene glycol methyl ether acetate, ethylene glycol phenyl ether, dipropylene glycol methyl ether, dipropylene glycol dimethyl ether, and propylene glycol butyl ether, or a mixture of two or more of them in any proportion.

[0043] The present invention also provides an application of the insecticide composition in the field of sanitary pests for preventing and controlling sanitary pests through space spraying.

[0044] In the above technical solution, the sanitary pest space refers to spaces such as hotels, schools, factories, homes, and public places.

[0045] In the above technical scheme, the sanitary pests are mosquitoes, flies, etc., specifically referring to Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Argonautus harassingus, Chironomids, housefly, city fly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia bright, summer toilet fly, Yuan toilet fly, bed bug, human flea, Ixodes persulcatus, Ixodes sinensis, Ixodes prairies, Boophilus microplus, Gamas or scabies.

[0046] In the above technical scheme, when the insecticide composition is used in the field of sanitary pests for controlling sanitary pests by space spraying, the insecticide composition can be used directly, and the liquid medicine can be sprayed into the space using a thermal fog machine; the insecticide composition can be diluted 20-40 times with water, and the liquid medicine can be sprayed into the space using an ultra-low volume device; the insecticide composition can be diluted 50-200 times with water, and the liquid medicine can be sprayed into the space using a constant volume spray device.

[0047] Compared with the existing technology, it has the following characteristics:

[0048] (1) Using a piperic acid derivative compound to control sanitary pests;

[0049] (2) The synergistic effect of compounding with pyrethroids is obvious, which reduces the dosage of pesticides;

[0050] (3) It has the performance of space spraying and lasting effect;

[0051] (4) Less irritating to the skin and safer for applicators. DETAILED DESCRIPTION

[0052] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0053] The laboratory preparation method of emulsifiable concentrate is as follows: weigh active ingredient A, active ingredient B, emulsifier, persistence promoter and solvent in proportion, heat and mix them evenly in a beaker to obtain the emulsifiable concentrate.

[0054] The laboratory preparation method of water-in-water emulsion is as follows: active ingredient A, active ingredient B, solvent, persistence promoter, and emulsifier are weighed in proportion, heated and dissolved to form an oil phase; antifreeze, defoaming agent, and water are weighed in proportion and mixed to form an aqueous phase; under high-speed shear conditions, the aqueous phase is slowly added to the oil phase to obtain the water-in-water emulsion.

[0055] The laboratory preparation method of the microemulsion is: weigh the active ingredient A, active ingredient B, emulsifier, solvent, and effect-promoting agent in proportion, heat and dissolve them completely, add water under stirring, and stir evenly to obtain the microemulsion.

[0056] Soluble liquid: Weigh active ingredient A, active ingredient B, emulsifier, persistence promoter and solvent in proportion, heat until fully dissolved, and then the soluble liquid can be prepared.

[0057] Thermal fogging agent: Weigh active ingredient A, active ingredient B, effect-enhancing agent and solvent in proportion, heat and dissolve them completely to obtain the thermal fogging agent.

[0058] Suspoemulsion: weigh active ingredient B, solvent and emulsifier in proportion, add water after complete dissolution, stir evenly, add dispersant, wetting agent, active ingredient A, antifreeze, thickener and preservative, mix evenly, shear with a high-speed shearing machine for 5 minutes, transfer to a sand mill and sand grind for 2-3 hours to control the particle size D90 below 5μm, and then the spoemulsion can be obtained.

[0059] The present invention will be described below in conjunction with specific embodiments:

[0060] Formulation Example 1: 11% Compound I-72·Permethrin emulsifiable concentrate

[0061] I-7210g, tetrafluthrin 1g, calcium dodecylbenzene sulfonate 3g, castor oil polyoxyethylene ether 5g, phenylphenol polyoxyethyl ether phosphate 2g, propylene glycol phenyl ether 20g, N, N-dimethylacetamide to 100g

[0062] Formulation Example 2: 5.5% Compound I-72·Tetrafluoroether aqueous emulsion

[0063] Compound I-725g, tetrafluthrin 0.5g, N,N-dimethylacetamide 8g, dipropylene glycol methyl ether acetate 10g, phenylphenol polyoxyethyl ether phosphate 5g, castor oil polyoxyethylene ether 3g, calcium dodecylbenzene sulfonate 1g, ethylene glycol 5g, polydimethylsiloxane 0.2g, and water to 100g.

[0064] Formulation Example 3: 4.5% Compound I-72·Permethrin Microemulsion

[0065] Compound I-724g, tetrafluthrin 0.5g, calcium dodecylbenzenesulfonate 4g, castor oil polyoxyethylene ether 16g, N-methyl pyrrolidone 14g, propylene glycol butyl ether 6g, water to 100g.

[0066] Formulation Example 4: 12% Compound I-72·Permethrin Soluble Liquid

[0067] Compound I-728g, tetrafluthrin 4g, calcium dodecylbenzene sulfonate 5g, castor oil polyoxyethylene ether 12g, agricultural milk 34# 6g, dipropylene glycol methyl ether 10g, piperonyl butoxide 2g, N,N-dimethylpropionamide is supplemented to 100g.

[0068] Formulation Example 5: 9% Compound I-72·Perfluthrin emulsifiable concentrate

[0069] Compound I-728g, tetrafluthrin 1g, calcium dodecylbenzenesulfonate 3g, Ningru 36# 6g, phenylphenol polyoxyethyl ether phosphate 1g, ethylene glycol phenyl ether 15g, N, N-dimethylacetamide to 100g

[0070] Formulation Example 6: 5% Compound I-72·Tetrafluoromethyl ether aqueous emulsion

[0071] Compound I-724.5g, tetrafluorothion 0.5g, N,N-dimethylcaprylamide 12g, dipropylene glycol methyl ether 10g, alkylphenol polyoxyethylene ether phosphate 6g, castor oil polyoxyethylene ether 2g, calcium dodecylbenzene sulfonate 2g, ethylene glycol 5g, polydimethylsiloxane 0.2g, and water to 100g.

[0072] Formulation Example 7: 5.5% Compound I-72·Permethrin Microemulsion

[0073] Compound I-725g, tetrafluthrin 0.5g, calcium dodecylbenzenesulfonate 4.2g, castor oil polyoxyethylene ether

[0074] 15.5g, cyclohexanone 15g, dipropylene glycol dimethyl ether 5g, and water to 100g.

[0075] Formulation Example 8: 12% Compound I-72·Permethrin Soluble Liquid

[0076] Compound I-7210g, tetrafluorothion 2g, calcium dodecylbenzenesulfonate 6g, castor oil polyoxyethylene ether 12g, agricultural milk 34# 8g, dipropylene glycol methyl ether 20g, piperonyl butoxide 5g, N,N-dimethylacetamide is supplemented to 100g.

[0077] Formulation Example 9: 11% Compound I-72·Metofluthrin EC

[0078] Compound I-7210g, metofluthrin 1g, calcium dodecylbenzenesulfonate 6g, styrylphenol polyoxyethylene ether 7g, dipropylene glycol methyl ether acetate 40g, and N,N-dimethylacetamide to 100g.

[0079] Formulation Example 10: 5% Compound I-72·Metofluthrin Emulsion in Water

[0080] Compound I-724.5g, 0.5g of cypermethrin, 15g of N,N-dimethyl decanoic acid amide, 10g of dipropylene glycol methyl ether acetate, 5g of alkylphenol polyoxyethylene ether phosphate, 3g of castor oil polyoxyethylene ether, 2g of calcium dodecylbenzene sulfonate, 5g of ethylene glycol, 0.2g of polydimethylsiloxane, and water to 100g.

[0081] Formulation Example 11: 7% Compound I-72·Metofluthrin Microemulsion

[0082] Compound I-726g, metofluthrin 1g, calcium dodecylbenzenesulfonate 5g, castor oil polyoxyethylene ether 20g, N,N-dimethylacetamide 25g, dipropylene glycol methyl ether acetate 5g, water to 100g.

[0083] Formulation Example 12: 15% Compound I-72·Metofluthrin Soluble Liquid

[0084] Compound I-7210g, metofluthrin 5g, calcium dodecylbenzene sulfonate 2g, castor oil polyoxyethylene ether 15g, agricultural milk 34#13g, dipropylene glycol methyl ether acetate 20g, piperonyl butoxide 5g, N,N-dimethylacetamide made up to 100g.

[0085] Formulation Example 13: 1% Compound I-72·Metofluthrin Thermal Mist

[0086] Compound I-720.9g, metofluthrin 0.1g, dipropylene glycol methyl ether acetate 40g, N,N-dimethylacetamide 8g, and odorless kerosene to 100g.

[0087] Formulation Example 14: 21% Compound I-72·Metofluthrin Suspension Emulsion

[0088] Compound I-7220g, metofluthrin 1g, calcium dodecylbenzenesulfonate 0.5g, castor oil polyoxyethylene ether 1g, ethylene oxide-propylene oxide block copolymer 0.5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium alkyl sulfonate 2g, diisopropyl adipate 5g, xanthan gum 0.25g, white carbon black 1.5g, potassium sorbate 0.5g, propylene glycol 4g, water to 100g.

[0089] Formulation Example 15: 3.5% Compound I-72·D-trans-chlorpromazine emulsifiable concentrate

[0090] Compound I-723g, 2-trans-chlorpropyl thrin 0.5g, calcium dodecylbenzenesulfonate 6g, polyoxyethylene styrylphenol ether 7g, polyoxyethylene castor oil ether 2g, dipropylene glycol methyl ether acetate 35g, diisopropyl adipate 10g, and N,N-dimethyldecanoamide to 100g.

[0091] Formulation Example 16: 4.5% Compound I-72·D-trans-chlorpromazine aqueous emulsion

[0092] Compound I-724g, 2-trans-chlorpropyl thrin 0.5g, N,N-dimethyl decanoic acid 12g, dipropylene glycol dimethyl ether 5g, alkylphenol polyoxyethylene ether phosphate 5g, ethylene oxide-propylene oxide block copolymer 4g, calcium dodecylbenzene sulfonate 1g, glycerol 3g, silicone oil 0.3g, and water to 100g.

[0093] Formulation Example 17: 5.5% Compound I-72·D-trans-chlorpromazine microemulsion

[0094] Compound I-725g, 2-trans-chlorpromazine 0.5g, calcium dodecylbenzenesulfonate 2g, castor oil polyoxyethylene ether 20g, ethylene oxide-propylene oxide block copolymer 5g, N,N-dimethylacetamide 20g, dipropylene glycol dimethyl ether 8g, water to 100g.

[0095] Formulation Example 18: 9% Compound I-72·D-trans-chlorpromazine soluble liquid

[0096] Compound I-726g, 3g of right-rotating trans-chlorprophphenate, 2g of calcium dodecylbenzenesulfonate, 10g of castor oil polyoxyethylene ether, 8g of phenylphenol polyoxyethyl ether phosphate, 30g of propylene glycol phenyl ether, 5g of piperonyl butoxide, and N,N-dimethylpropionamide to 100g.

[0097] Formulation Example 19: 2% Compound I-72·D-trans-chlorpromazine thermal spray

[0098] Compound I-721g, d-trans-chlorprophphenate 1g, dipropylene glycol methyl ether acetate 40g, diisopropyl adipate 15g, and odorless kerosene to 100g.

[0099] Formulation Example 20: 30% Compound I-72·D-trans-chlorpromazine pyrethrin suspension emulsion

[0100] Compound I-7225g, 5g of dextrorotatory trans-chlorprophphenate, 0.6g of calcium dodecylbenzenesulfonate, 0.8g of castor oil polyoxyethylene ether, 0.8g of ethylene oxide-propylene oxide block copolymer, 5g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 2g of sodium alkyl sulfonate, 8g of diisopropyl adipate, 0.25g of xanthan gum, 1.5g of white carbon black, 0.5g of potassium sorbate, 4g of propylene glycol, and water to 100g.

[0101] Formulation Example 21: 6% Compound I-72·Transfluthrin EC

[0102] Compound I-724g, transfluthrin 2g, calcium dodecylbenzenesulfonate 7g, styrylphenol polyoxyethylene ether 2g, castor oil polyoxyethylene ether 4g, propylene glycol phenyl ether 40g, tributyl citrate 10g, and N,N-dimethylacetamide to 100g.

[0103] Formulation Example 22: 5% Compound I-72·Transfluthrin Emulsion in Water

[0104] Compound I-724g, transfluthrin 1g, N,N-dimethyl decanoic acid 13g, propylene glycol phenyl ether 2g, alkylphenol polyoxyethylene ether phosphate 4.5g, ethylene oxide-propylene oxide block copolymer 4g, calcium dodecylbenzene sulfonate 1.5g, ethylene glycol 3g, silicone oil 0.3g, water to 100g.

[0105] Formulation Example 23: 4.5% Compound I-72·Transfluthrin Microemulsion

[0106] Compound I-724g, transfluthrin 0.5g, calcium dodecylbenzene sulfonate 2g, castor oil polyoxyethylene ether 18g, fatty alcohol polyoxyethylene ether 4g, N,N-dimethylacetamide 17g, dipropylene glycol dimethyl ether 5g, water to 100g.

[0107] Formulation Example 24: 10% Compound I-72·Transfluthrin Soluble Liquid

[0108] Compound I-725g, transfluthrin 5g, calcium dodecylbenzene sulfonate 2g, castor oil polyoxyethylene ether 10g, phenylphenol polyoxyethyl ether phosphate 8g, ethylene glycol phenyl ether 25g, tributyl citrate 6g, and N,N-dimethylacetamide to 100g.

[0109] Formulation Example 25: 1.5% Compound I-72·Transfluthrin Hot Mist

[0110] Compound I-721g, transfluthrin 0.5g, dipropylene glycol methyl ether acetate 35g, propylene glycol phenyl ether 12g, and odorless kerosene to 100g.

[0111] Formulation Example 26: 15% Compound I-72·Transfluthrin Suspension Emulsion

[0112] Compound I-7210g, 5g of dextrorotatory trans-chlorprophphenate, 0.5g of calcium dodecylbenzenesulfonate, 1g of fatty alcohol polyoxyethylene ether, 0.5g of ethylene oxide-propylene oxide block copolymer, 4g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 2.5g of sodium alkyl sulfonate, 10g of diisopropyl adipate, 0.35g of xanthan gum, 1.0g of magnesium aluminum silicate, 0.5g of potassium sorbate, 4g of propylene glycol, and water to make up to 100g.

[0113] Formulation Example 27: 6% Compound I-72·D-phenothrin emulsifiable concentrate

[0114] Compound I-724g, 2g of dextrorotatory phenoxythrin, 5g of calcium dodecylbenzene sulfonate, 4g of fatty alcohol polyoxyethylene ether, 2g of castor oil polyoxyethylene ether, 25g of ethylene glycol phenyl ether, 12g of trimethylolbenzene, and N-methylpyrrolidone made up to 100g.

[0115] Formulation Example 28: 5% Compound I-72·D-phenothrin Emulsion in Water

[0116] Compound I-724g, 1g of dextrorotatory phenthrin, 15g of N,N-dimethyl decanoic acid amide, 3g of dipropylene glycol methyl ether, 5g of alkylphenol polyoxyethylene ether phosphate, 3g of ethylene oxide-propylene oxide block copolymer, 1.2g of calcium dodecylbenzene sulfonate, 5g of ethylene glycol, 0.3g of silicone oil, and water to 100g.

[0117] Formulation Example 29: 7% Compound I-72·D-phenothrin Microemulsion

[0118] Compound I-725g, 2g of dextrorotatory phenoxythrin, 2g of ethylene oxide-propylene oxide block copolymer, 15g of castor oil polyoxyethylene ether, 6g of fatty alcohol polyoxyethylene ether, 20g of N,N-dimethylacetamide, 5g of propylene glycol butyl ether, and water to 100g.

[0119] Formulation Example 30: 12% Compound I-72·D-phenothrin soluble liquid

[0120] Compound I-726g, dextrorotatory phenoxythrin 6g, sorbitan monostearate 5g, alkylphenol polyoxyethylene ether 5g, phenylphenol polyoxyethyl ether phosphate 10g, ethylene glycol phenyl ether 25g, cyclohexanone 10g, and N,N-dimethylacetamide to 100g.

[0121] Formulation Example 31: 7% Compound I-72·Sepfluthrin EC

[0122] Compound I-726g, 1g of cypermethrin, 4.5g of calcium dodecylbenzenesulfonate, 3g of fatty alcohol polyoxyethylene ether, 3.5g of castor oil polyoxyethylene ether, 20g of dipropylene glycol dimethyl ether, 10g of dodecylbenzene, and N,N-dimethylpropionamide to 100g.

[0123] Formulation Example 32: 4.5% Compound I-72·Sepfluthrin Emulsion in Water

[0124] Compound I-724g, 0.5g of cypermethrin, 12g of N,N-dimethyl decanoic acid amide, 8g of dipropylene glycol methyl ether, 6g of alkylphenol polyoxyethylene ether phosphate, 4g of ethylene oxide-propylene oxide block copolymer, 2g of calcium dodecylbenzene sulfonate, 5g of ethylene glycol, 0.3g of polydimethylsiloxane, and water to 100g.

[0125] Formulation Example 33: 5% Compound I-72·Sepfluthrin Microemulsion

[0126] Compound I-724g, 1g of cypermethrin, 2g of ethylene oxide-propylene oxide block copolymer, 14g of castor oil polyoxyethylene ether, 4g of fatty alcohol polyoxyethylene ether, 20g of N,N-dimethylacetamide, 5g of dipropylene glycol methyl ether acetate, and water to make up to 100g.

[0127] Formulation Example 34: 8% Compound I-72·Sepfluthrin Soluble Liquid

[0128] Compound I-724g, 4g of cypermethrin, 3g of sorbitan monostearate, 6g of alkylphenol polyoxyethylene ether, 10g of phenylphenol polyoxyethyl ether phosphate, 25g of dipropylene glycol methyl ether, 10g of cyclohexanone, and N,N-dimethylacetamide to 100g.

[0129] Formulation Example 35: 11% Compound I-72·D-tefomethrin emulsifiable concentrate

[0130] Compound I-7210g, dextrorotatory fenvalerate 1g, calcium dodecylbenzenesulfonate 7g, fatty alcohol polyoxyethylene ether 3g, castor oil polyoxyethylene ether 4g, dipropylene glycol dimethyl ether 20g, cyclohexanone 15g, and N,N-dimethylacetamide to 100g.

[0131] Formulation Example 36: 4.5% Compound I-72·D-tefothrin Emulsion in Water

[0132] Compound I-724g, dextrorotatory fenvalerate 0.5g, N,N-dimethyl decanoic acid 10g, dipropylene glycol methyl ether 8g, alkylphenol polyoxyethylene ether phosphate 5.5g, ethylene oxide-propylene oxide block copolymer 4g, calcium dodecylbenzene sulfonate 2g, glycerol 5g, polydimethylsiloxane 0.3g, and water to 100g.

[0133] Formulation Example 37: 7% Compound I-72·D-tefothrin Microemulsion

[0134] Compound I-726g, 1g of dextrorotatory fenvalerate, 3g of ethylene oxide-propylene oxide block copolymer, 12g of castor oil polyoxyethylene ether, 3g of fatty alcohol polyoxyethylene ether, 20g of N,N-dimethylpropionamide, 5g of dipropylene glycol methyl ether acetate, and water to make up to 100g.

[0135] Formulation Example 38: 12% Compound I-72·D-tefothrin soluble liquid

[0136] Compound I-7210g, dextrorotatory fenvalerate 2g, sorbitan monostearate 5g, alkylphenol polyoxyethylene ether 5g, phenylphenol polyoxyethyl ether phosphate 10g, dipropylene glycol methyl ether 25g, cyclohexanone 10g, and N,N-dimethylacetamide to 100g.

[0137] Formulation Example 39: 11% Compound I-72·Clonazepam EC

[0138] Compound I-7210g, chlorpyrifos 1g, calcium dodecylbenzene sulfonate 7g, fatty alcohol polyoxyethylene ether 2g, alkylphenol polyoxyethylene ether phosphate 5g, propylene glycol butyl ether 20g, diisopropyl adipate 18g, and N,N-dimethylacetamide to 100g.

[0139] Formulation Example 40: 5% Compound I-72·Clonazepam Emulsion in Water

[0140] Compound I-724g, chlorpyrifos 1g, N-methylpyrrolidone 12g, propylene glycol phenyl ether 6g, castor oil polyoxyethylene ether 5g, ethylene oxide-propylene oxide block copolymer 3g, calcium dodecylbenzenesulfonate 3g, glycerol 5g, polydimethylsiloxane 0.3g, and water to 100g.

[0141] Formulation Example 41: 4.5% Compound I-72·Clonazepam Microemulsion

[0142] Compound I-724g, chlorpyrifos 0.5g, ethylene oxide-propylene oxide block copolymer 3g, castor oil polyoxyethylene ether 12g, fatty alcohol polyoxyethylene ether 3g, N,N-dimethylpropionamide 20g, dipropylene glycol methyl ether acetate 5g, water to 100g.

[0143] Formulation Example 42: 12% Compound I-72·Chlorpheniramine Soluble Liquid

[0144] Compound I-7210g, chlorpyrifos 2g, sorbitan monostearate 4g, alkylphenol polyoxyethylene ether 4g, phenylphenol polyoxyethyl ether phosphate 12g, dipropylene glycol methyl ether 25g, acetyl tributyl citrate 10g, and N,N-dimethylacetamide to 100g.

[0145] Formulation Example 43: 9% Compound I-72·Bio-Allethrin EC

[0146] Compound I-726g, bio-allylthrin 3g, calcium dodecylbenzene sulfonate 7g, castor oil polyoxyethylene ether 3g, phenylphenol polyoxyethyl ether phosphate 2g, propylene glycol phenyl ether 20g, N,N-dimethylacetamide to 100g.

[0147] Formulation Example 44: 6% Compound I-72·D-allethrin aqueous emulsion

[0148] Compound I-725g, d-allylthrin 1g, N,N-dimethylacetamide 6g, dipropylene glycol methyl ether acetate 12g, phenylphenol polyoxyethyl ether phosphate 4g, castor oil polyoxyethylene ether 4g, calcium dodecylbenzene sulfonate 2g, urea 2g, polydimethylsiloxane 0.2g, water to 100g.

[0149] Formulation Example 45: 4.5% Compound I-72·Rich in D-trans-Allethrin Microemulsion

[0150] Compound I-724g, right-rotating trans-allylthrin 0.5g, calcium dodecylbenzenesulfonate 4g, castor oil polyoxyethylene ether 16g, N-methylpyrrolidone 14g, propylene glycol butyl ether 6g, water to 100g.

[0151] Formulation Example 46: 10% Compound I-72·Rich in D-trans-Allethrin Soluble Liquid

[0152] Compound I-728g, right-handed trans-allyl threthrin 2g, calcium dodecylbenzene sulfonate 4g, castor oil polyoxyethylene ether 12g, agricultural milk 34# 6g, dipropylene glycol methyl ether 10g, piperonyl butoxide 2g, N,N-dimethylpropionamide supplemented to 100g.

[0153] Application Example 1: Indoor efficacy test for controlling mosquitoes and flies

[0154] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0155] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0156] Test method: refer to GB / T 13917.10-2009, simulate the site, and use the simulated room hanging cage method to conduct the test;

[0157] Application method: Ultra-low volume spray

[0158] Dosage setting: The spray concentration of the active ingredient in the preparation examples is 1.5 mg / m 3 ;

[0159] Control sample: Control sample 1: 5% compound I-72 soluble solution, spraying dose 1.5 mg / m 3 ; Control sample 2: 5% metofluthrin emulsifiable concentrate, spraying dose 1.5 mg / m 3 ; Control sample 3: 5% D-trans-chlorpromazine emulsifiable concentrate, spraying dose 1.5 mg / m 3 ; Control sample 4: 5% transfluthrin emulsifiable concentrate, spraying dose 1.5 mg / m 3 The control sample also selected the mainstream space spraying preparation on the market, control sample 5: 10.4% chlorpyrifos·allethrin emulsion (Jiangsu Gongcheng Biotechnology Co., Ltd.), spraying dose 1.5 mg / m 3 ; Control sample 6: 5% chlorpyrifos·permethrin emulsion (Jiangsu Youjia Plant Protection Co., Ltd.), spraying dose 1.5 mg / m 3 ;

[0160] Test results:

[0161] Table 1: Efficacy test of the preparation examples against Culex pipiens pallens and housefly

[0162]

[0163]

[0164] The test results show that the above-mentioned formulation examples are better than the commercially available control sample 5 (10.4% chlorpyrifos·permethrin emulsion) in knockdown effect against Culex pipiens pallens and housefly, and the knockdown effect of some formulation examples is better than the commercially available control sample 6 (5% chlorpyrifos·permethrin emulsion), and the 24h lethality is all above 90%, among which the lethality of formulation examples 9-12, 15-18, 21, 22, and 24 all reaches 100% (see Table 1). It can be seen that the formulation examples can achieve the efficacy of the mainstream space sprays currently on the market, and the efficacy of some examples is significantly better than the control.

[0165] Application Example 2: Determination of the co-toxicity coefficient of compound I-72 and pyrethroids

[0166] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0167] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0168] Table 2 Determination of the co-toxicity coefficient of compound I-72 and metofluthrin (for houseflies)

[0169]

[0170] As shown in Table 2, when the compound I-72 and metofluthrin are mixed in a ratio of 50:1 to 1:1, the co-toxicity coefficient against houseflies is greater than 120, and there is a synergistic effect, especially when the compound ratio is 10:1, the synergistic effect is most obvious.

[0171] Table 3 Determination of the co-toxicity coefficient of compound I-72 and D-trans-chlorpromazine (for houseflies)

[0172]

[0173]

[0174] As shown in Table 3, when the compound I-72 and d-trans-chlorpromazine are mixed in a ratio of 50:1 to 1:6, the co-toxicity coefficient against houseflies is greater than 120, and there is a synergistic effect, especially when the mixing ratio is 6:1, the synergistic effect is most obvious.

[0175] Table 4 Determination of the co-toxicity coefficient of compound I-72 and transfluthrin (for houseflies)

[0176]

[0177]

[0178] As shown in Table 4, when the compound I-72 and transfluthrin are mixed in a ratio of 20:1 to 1:1, the co-toxicity coefficient against houseflies is greater than 120, and there is a synergistic effect, especially when the compound ratio is 2:1, the synergistic effect is most obvious.

[0179] Table 5 Optimal co-toxicity coefficient of compound I-72 and other pyrethroids (for houseflies)

[0180]

[0181] As can be seen from Table 5, the optimal ratios of compound I-72 and other pyrethroids after compounding are all in the range of 10:1 to 2:1, especially for tetrafluthrin, sphenoxythrin, dextrorotatory sphenoxythrin and chlorfenapyr, the co-toxicity coefficients all reach more than 200, and the synergistic effect is obvious.

[0182] Application Example 3: Efficacy Test of Prolonged Effect Agent

[0183] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0184] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0185] Test method: Cover the floor of the simulated room with filter paper, use an ultra-low volume sprayer to spray the pesticide into the simulated room, remove the filter paper after 2 hours, turn on the exhaust device, exhaust for 1 hour, then turn off the exhaust and put in 100 test insects to test whether the pesticide will adhere to the glass surface around the simulated room and have a lasting effect;

[0186] Test treatment: Preparation Example 9 and Control Sample 3 (Based on the formulation of Preparation Example 9, dipropylene glycol methyl ether acetate was replaced by N, N-dimethylacetamide), spraying dose was 1.5 mg / m 3 ;

[0187] Spray equipment: ultra-low volume sprayer;

[0188] Table 6 Pharmacodynamic data of the effect of the agonist

[0189]

[0190]

[0191] After the above test treatment, there was no drug residue on the ground in the simulation room (the drug-stained filter paper was removed), and there was basically no drug residue in the space (ventilation for 1 hour). There were droplets adhering to the side of the simulation room. From the test results, the drug effect of dipropylene glycol methyl ether acetate added in Preparation Example 9 was significantly better than that of Control Sample 3. This shows that dipropylene glycol methyl ether acetate has a certain promoting effect on the sustained effect of space spraying.

[0192] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A space spraying insecticide composition containing a piperic acid derivative compound, characterized in that: The active ingredients are composed of active ingredient A and active ingredient B, and the total weight of active ingredient A and active ingredient B accounts for 0.2% to 30% of the insecticide composition by weight, and the balance is auxiliary materials; The active ingredient A is a piperic acid derivative compound shown in formula I; The active ingredient B is selected from any one of cypermethrin, tetrafluthrin, methoxyfluthrin, d-trans chlorpropthrin, cypermethrin, d-phenothrin, sepfluthrin, d-sepfluthrin, bio-allethrin, chlorfenthrin, d-allethrin, and d-trans allethrin; The weight ratio of the piperic acid derivative compound to tetrafluthrin is 10:1-2:1; the weight ratio of the piperic acid derivative compound to tetrafluthrin is 10:1-5:1; the weight ratio of the piperic acid derivative compound to methifluthrin is 20:1-2:1; the weight ratio of the piperic acid derivative compound to dextro-trans-chlorprothrin is 10:1-1:1; the weight ratio of the piperic acid derivative compound to transfluthrin is 8:1-1:1; the weight ratio of the piperic acid derivative compound to dextro-phenothrin is 4:1-1:1; The weight ratio of the piperic acid derivatives to sepfluthrin is 8:1 to 1:1; the weight ratio of the piperic acid derivatives to dextrosepfluthrin is 10:1 to 5:1; the weight ratio of the piperic acid derivatives to chlorpyrifos is 10:1 to 4:1; the weight ratio of the piperic acid derivatives to bio-allethrin is 8:1 to 2:1; the weight ratio of the piperic acid derivatives to dextrosepfluthrin is 8:1 to 2:1; the weight ratio of the piperic acid derivatives to dextrosepfluthrin is 8:1 to 2:1; the weight ratio of the piperic acid derivatives to dextrosepfluthrin is 8:1 to 2:1; 2. The insecticidal composition according to claim 1, characterized in that The insecticide composition is in the form of emulsifiable concentrate, water emulsion, microemulsion, soluble liquid, thermal fog agent or suspoemulsion, and the auxiliary materials can be any one of solvents, emulsifiers, dispersants, wetting agents, defoamers, antifreeze agents, preservatives, thickeners, and persistent agents, or a mixture of two or more in any proportion.

3. The insecticidal composition according to claim 2, characterized in that The insecticidal composition, when in the form of emulsifiable concentrate, comprises 1%-10% active ingredient A, 0.1%-5% active ingredient B, 8%-20% emulsifier, 10%-40% effect-promoting agent, and the solvent is supplemented to 100%; the insecticidal composition, when in the form of aqueous emulsion, comprises 1%-10% active ingredient A, 0.1%-5% active ingredient B, 5%-20% solvent, 2%-15% effect-promoting agent, 8%-15% emulsifier, 1%-5% antifreeze agent, 0.1%-0.5% defoaming agent, and the water is supplemented to 100%.

4. The insecticidal composition according to claim 2, characterized in that The insecticide composition, when in the form of a microemulsion, comprises 1%-10% active ingredient A, 0.1%-5% active ingredient B, 15%-30% emulsifier, 10%-30% solvent, 2%-10% prolonging agent, and the water content is 100%; the insecticide composition, when in the form of a soluble liquid, comprises 1%-10% active ingredient A, 1%-10% active ingredient B, 15%-30% emulsifier, 10%-30% prolonging agent, and the solvent content is 100%.

5. The insecticidal composition according to claim 2, characterized in that: The insecticide composition, when in the form of a thermal fog agent, comprises 0.1%-2% active ingredient A, 0.1%-2% active ingredient B, 30%-50% promoting long-lasting agent, and the solvent is supplemented to 100%; the insecticide composition, when in the form of a suspoemulsion, comprises 5%-25% active ingredient A, 1%-5% active ingredient B, 1%-3% emulsifier, 2%-8% dispersant, 1%-5% wetting agent, 5%-10% solvent, 0.1%-3% thickener, 0.1%-2% preservative, 1%-5% antifreeze, and water is supplemented to 100%.

6. The insecticidal composition according to claim 2, characterized in that The effect-promoting agent can be any one of propylene glycol phenyl ether, dipropylene glycol methyl ether acetate, ethylene glycol phenyl ether, dipropylene glycol methyl ether, dipropylene glycol dimethyl ether, and propylene glycol butyl ether, or a mixture of two or more of them in any proportion.

7. Use of the insecticide composition according to claim 1 in the field of sanitary pests for controlling sanitary pests by space spraying, wherein the sanitary pest space refers to hotels, schools, factories, homes, and public places; and the sanitary pests are mosquitoes and flies.

8. The use according to claim 7, characterized in that: When controlling sanitary pests by spraying in space, the insecticide composition is used directly, and the liquid medicine is sprayed into the space by a thermal fog machine; or the insecticide composition is diluted 20-40 times with water, and the liquid medicine is sprayed into the space by an ultra-low volume equipment; or the insecticide composition is diluted 50-200 times with water, and the liquid medicine is sprayed into the space by a constant volume spray equipment.

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