Rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials

Abstract

The present invention discloses a rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials in the field of Chinese herbal medicine detection. The system comprises a box body, an opening is provided on the box body, an extraction chamber and a detection chamber are provided in the box body, the opening and the detection chamber are both connected to the extraction chamber, and an extraction component is provided in the extraction chamber; a COFs adsorption plate is provided on the side wall of the detection chamber, a one-way valve is provided at the bottom of the detection chamber, a first cylinder is fixedly connected to the top wall of the detection chamber, a detection component is provided on the output shaft of the first cylinder, the detection component comprises a color developer bottle, a nozzle is connected to the bottom of the color developer bottle, a color collector is fixedly connected to the outside of the bottom of the color developer bottle, the color collector comprises a controller box, a controller is provided in the controller box, a camera and a light source are fixedly connected on the side of the controller box close to the COFs adsorption plate, and a power supply is provided in the bottom wall of the box body. Harmful substances are enriched by the covalent organic framework material to improve the degree of color change.

Description

Technical Field

[0001] The present invention belongs to the field of Chinese herbal medicine detection, and in particular is a rapid detection system for harmful substances in Chinese herbal medicine based on covalent organic framework materials. Background Art

[0002] Traditional Chinese medicine (TCM) refers to drugs whose collection, processing, and preparation, along with explanations of their mechanisms of action and clinical application, are guided by traditional Chinese medicine theory. These substances, guided by TCM theory, are used to prevent, treat, and diagnose diseases and have therapeutic and health-promoting properties. TCM primarily originates from natural medicinal products and their processed products, including botanicals, animal medicines, minerals, and some chemical and biological products. Because botanicals predominate in TCM, there's a saying that "all medicines are based on herbs." Today's TCMs are diverse and sourced from a wide range of sources. Each of these materials possesses a variety of chemical components. Based on their pharmacological effects and compositional properties, TCM ingredients can be broadly categorized as active ingredients, auxiliary ingredients, inactive ingredients, harmful ingredients, and tissue substances. Before a TCM is officially released for use, it's often necessary to effectively analyze and detect harmful components within it using testing equipment to determine its medicinal value and ensure its overall effectiveness.

[0003] In order to solve the above problems, patent publication number CN211318215U discloses a rapid detection device for harmful substances in traditional Chinese medicine, including a water bath, a first servo motor and a second servo motor. The water bath is provided with limiting grooves at both left and right ends. The first servo motor is installed on the lower surface of the water bath. The outer side of the screw rod is threadedly connected to a receiving plate, and a placement plate is provided above the receiving plate. The inner bottom end of the cuvette is contaminated with a pad, and the outer side of the protective cover is vertically fixedly connected to a transparent label plate, and a writing board is provided above the transparent label plate. The second servo motor is located on the right side of the water bath, and the output end of the second servo motor is connected to a turntable.

[0004] The above-mentioned rapid detection device for harmful substances in traditional Chinese medicine uses a colorimetric reaction to check whether the traditional Chinese medicine contains harmful substances. However, the extract of traditional Chinese medicine is usually colored, which will interfere with the color produced by the color development reaction and affect the colorimetric judgment; when the concentration of harmful substances in traditional Chinese medicine is low, the color change value of the color development reaction is small and difficult to observe. Summary of the Invention

[0005] In order to solve the problem in the prior art that when the concentration of harmful substances in traditional Chinese medicine is low, the color change value of the color development reaction is small and difficult to observe, the purpose of the present invention is to provide a rapid detection system for harmful substances in traditional Chinese medicine based on covalent organic framework materials, which enriches harmful substances through covalent organic framework materials and improves the color change degree.

[0006] To achieve the above-mentioned object, the technical solution of the present invention is as follows: a rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials, comprising a box body, an opening being provided on the box body, an extraction chamber and a detection chamber being provided in the box body, the opening and the detection chamber being both connected to the extraction chamber, and an extraction component being provided in the extraction chamber;

[0007] A COFs adsorption plate is provided on the side wall of the detection chamber, a one-way valve is provided at the bottom of the detection chamber, a first cylinder is fixedly connected to the top wall of the detection chamber, a detection assembly is provided on the output shaft of the first cylinder, the detection assembly includes a color developer bottle, a nozzle is connected to the bottom of the color developer bottle, a color collector is fixedly connected to the outer side of the bottom of the color developer bottle, the color collector includes a controller box, a controller is provided in the controller box, a camera and a light source are fixedly connected to the side of the controller box close to the COFs adsorption plate, and a power supply is provided in the bottom wall of the box;

[0008] The color collector is used to control the light source illumination and capture the initial image of the COFs adsorption plate through the camera when the output shaft of the first cylinder is extended, and to capture the color image of the COFs adsorption plate after the developer is sprayed by the nozzle, and to compare and calculate the color difference between the initial image and the color image;

[0009] The COFs adsorption plate is prepared by ultrasonically stirring a mixed solution of carbon source, trialdehyde phloroglucinol, oxalohydrazide, N,N-dimethylacetamide and dioxane, and reacting it in a reactor at 120°C for 72 hours. The solid reactant is taken out and cleaned to remove surface burrs, and then cleaned and dried.

[0010] The above solution achieves the following beneficial effects: the user can put the Chinese herbal medicine into the extraction chamber through the opening, and the extraction component will extract the juice of the Chinese herbal medicine and allow the juice to flow into the detection chamber.

[0011] A COFs adsorption plate is provided in the detection chamber. The COFs adsorption plate is made of a covalent organic framework material and has excellent stability, rich π functional sites, excellent electrical conductivity, high surface area and ordered porous structure. By applying voltage to the COFs adsorption plate, the metal ions or groups in the juice can be adsorbed, causing the metal ions or groups to converge on the COFs adsorption plate. Depending on the detection target, a COFs adsorption plate that adsorbs different ions or groups is selected. Therefore, after the juice flows into the detection chamber, it is left to stand for a period of time to allow the COFs adsorption plate to enrich the heavy metal ions or groups, and then the one-way valve is opened to discharge the juice. After the juice is discharged, some solution will still remain on the COFs adsorption plate. This part of the solution is enriched with heavy metal ions or groups, which can make the color reaction more obvious.

[0012] The output shaft of the first cylinder extends, lowering the detection assembly. The color collector captures an initial image of the COFs adsorption plate. After the developer is sprayed by the nozzle and fully reacted, the developed COFs adsorption plate is photographed and the color difference value is recorded.

[0013] Compared with the existing technology, harmful substances are enriched through the adsorption effect of the COFs adsorption plate, making the color difference of the color reaction more obvious, which is conducive to observation and makes the detection sensitivity higher; by comparing the images before and after the color reaction, the controller calculates the color difference, reducing the interference of the color of the Chinese herbal juice itself on the color reaction.

[0014] Furthermore, an osmosis cavity is provided on one side of the detection cavity, a semipermeable membrane is provided between the detection cavity and the osmosis cavity, and a high-concentration liquid layer is provided in the osmosis cavity.

[0015] Beneficial Effects: Chinese herbal juices still contain a large amount of water, which can disperse the concentration of substances. Drying with heat can cause some harmful substances to volatilize, affecting test results. By using the principle of differential osmosis, water will flow to the side with higher concentration, thereby reducing the water content of the herbal juice, increasing the concentration of harmful substances and improving detection sensitivity.

[0016] Furthermore, the squeezing assembly includes a second cylinder, which is fixedly connected to the top wall of the box body, and a lower pressure plate is fixedly connected to the output shaft of the second cylinder.

[0017] Beneficial effect: After the output shaft of the second cylinder is extended, the lower pressure plate squeezes the Chinese herbal medicine, squeezes out the juice in the Chinese herbal medicine, and facilitates the establishment of a liquid detection environment.

[0018] Furthermore, a grinding wheel is provided at the bottom of the lower pressing plate, and the grinding wheel is provided with a first motor for driving the grinding wheel to rotate.

[0019] Beneficial effect: The grinding wheel will grind the Chinese herbal medicine during the squeezing process, so that a large amount of juice can flow out, which is convenient for subsequent detection components to detect.

[0020] Furthermore, a light shielding plate is provided between the detection chamber and the extraction chamber, and a through opening is provided at the bottom of the light shielding plate.

[0021] Beneficial Effect: Natural light may enter the detection chamber from the extraction chamber and interfere with the color detection of the color collector. The light shield can block the external natural light, so that only one light source is contained in the detection chamber, thereby making the image color collected by the color collector more accurate.

[0022] Furthermore, a filter membrane is fixedly connected in the through port.

[0023] Beneficial Effects: The herbal grinding process produces fine debris. These debris can adhere to the COFs adsorption plate, impacting its performance. The filter membrane intercepts these debris, reducing their chance of entering the detection chamber. The opening connects to the extraction chamber, trapping the debris within and making it easier for the user to clean.

[0024] Furthermore, a second motor is provided at the bottom of the detection chamber, and a stirring paddle is fixedly connected to the output shaft of the second motor.

[0025] Beneficial Effects: Color development reactions often result from the binding of harmful substances to produce colored substances. When the COFs adsorption plate is powered off, the electromagnetic force disappears, and the adsorption of harmful substances decreases. At this point, deionized water is injected, and the second motor is activated to generate a water vortex that flushes the detection chamber and COFs adsorption plate, cleaning them and reducing interference with subsequent testing.

[0026] Furthermore, a display is fixedly connected to the outside of the box.

[0027] Beneficial effects: The display can show the initial image, the color image and the color difference value, making it convenient for users to obtain the detection information and process. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 Schematic diagram of an embodiment of the present invention.

[0029] Figure 2 for Figure 1 Enlarged schematic diagram of part A. DETAILED DESCRIPTION

[0030] The following is further described in detail through specific implementation methods:

[0031] The figure marks in the drawings of the specification include: box body 1, opening 2, extraction chamber 3, detection chamber 4, extraction component 5, COFs adsorption plate 6, one-way valve 7, first cylinder 8, color developer bottle 9, nozzle 10, color collector 11, controller box 12, camera 13, light source 14, power supply 15, permeation chamber 16, semipermeable membrane 17, second cylinder 18, lower pressure plate 19, grinding wheel 20, shading plate 21, filter membrane 22, second motor 23, stirring paddle 24, display 25.

[0032] Example 1

[0033] The embodiment is basically as shown in the attached Figure 1 and attached Figure 2 As shown:

[0034] The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials includes a box body 1, an opening 2 is opened on the box body 1, an extraction chamber 3 and a detection chamber 4 are provided in the box body 1, the opening 2 and the detection chamber 4 are both connected to the extraction chamber 3, and an extraction component 5 is provided in the extraction chamber 3;

[0035] A COFs adsorption plate 6 is bonded and fixed to the side wall of the detection chamber 4, a one-way valve 7 is provided at the bottom of the detection chamber 4, a first cylinder 8 is bolted to the top wall of the detection chamber 4, the model of the first cylinder 8 is SC32X125S, and a detection assembly is installed on the output shaft of the first cylinder 8. The detection assembly includes a color developer bottle 9, the bottom of the color developer bottle 9 is connected to a nozzle 10, and a color collector 11 is bolted to the outer side of the bottom of the color developer bottle 9. The color collector 11 includes a controller box 12, and a controller is screwed in the controller box 12. The model of the controller is YM-SMP01. A camera 13 and a light source 14 are screwed on one side of the controller box 12 close to the COFs adsorption plate 6. The model of the camera 13 is OV5647, and the model of the light source 14 is XYD-5. A power supply 15 is screwed in the bottom wall of the box body 1;

[0036] The color collector 11 is used to control the illumination of the light source 14 and collect the initial image of the COFs adsorption plate 6 through the camera 13 when the output shaft of the first cylinder 8 is extended, collect the color image of the COFs adsorption plate 6 after the nozzle 10 sprays the color developer, and compare and calculate the color difference value between the initial image and the color image.

[0037] COFs adsorption plate 6 is prepared by ultrasonically stirring a mixed solution of a carbon source, trialdehyde phloroglucinol, oxalohydrazide, N,N-dimethylacetamide, and dioxane. The mixture is then reacted in a reactor at 120°C for 72 hours. The solid reactant is then removed, cleaned, and surface burrs removed. The solid reactant is then cleaned and dried. The mass ratio of carbon source, trialdehyde phloroglucinol, oxalohydrazide, N,N-dimethylacetamide, and dioxane is 1:1:0.4:20:100. Glucose is used as the carbon source.

[0038] The specific implementation process is as follows: the user can put the Chinese herbal medicine into the extraction chamber 3 through the opening 2, and the extraction component 5 will extract the juice of the Chinese herbal medicine and make the juice flow into the detection chamber 4.

[0039] A COFs adsorption plate 6 is provided in the detection chamber 4. The COFs adsorption plate 6 is made of a covalent organic framework material and has excellent stability, rich π functional sites, excellent electrical conductivity, high surface area and ordered porous structure. By applying voltage to the COFs adsorption plate 6, the metal ions or groups in the juice can be adsorbed, so that the metal ions or groups are gathered on the COFs adsorption plate 6. Depending on the detection target, a COFs adsorption plate 6 that adsorbs different ions or groups is selected. Therefore, after the juice flows into the detection chamber 4, it is left to stand for a period of time to allow the COFs adsorption plate 6 to enrich the heavy metal ions or groups, and then the one-way valve 7 is opened to discharge the juice. After the juice is discharged, some solution will still remain on the COFs adsorption plate 6. This partial solution is enriched with heavy metal ions or groups, which can make the color reaction more obvious.

[0040] There can be multiple groups of COFs adsorption plates 6 and detection components to detect multiple harmful substances at the same time. Since the principle of adsorption enrichment is adopted, there is little interference between the detection of different harmful substances.

[0041] The output shaft of the first air cylinder 8 extends, lowering the detection assembly. The color collector 11 captures the initial image of the COFs adsorption plate 6. After the developer is sprayed by the nozzle 10 and the developer is fully reacted, the color-developed COFs adsorption plate 6 is captured and the color difference value is recorded.

[0042] The COFs adsorption plate 6 synthesized using the above formula can effectively adsorb heavy metal ions such as cadmium and lead ions, and enrich harmful substances.

[0043] This invention enriches harmful substances through the adsorption effect of the COFs adsorption plate 6, making the color difference of the color development reaction more obvious, facilitating observation, and making the detection sensitivity higher; by comparing the images before and after the color development reaction, the controller calculates the color difference, reducing the interference of the color of the Chinese herbal juice itself on the color development reaction.

[0044] Example 2

[0045] The difference from the above embodiment is that an osmotic cavity 16 is opened on one side of the detection cavity 4 , a semipermeable membrane 17 is bonded and fixed between the detection cavity 4 and the osmotic cavity 16 , and a high-concentration liquid layer is provided in the osmotic cavity 16 .

[0046] The specific implementation process is as follows: Chinese herbal juice still contains a large amount of water, which will disperse the concentration of substances; drying through heating will cause some harmful substances to volatilize, affecting the test results. Using the principle of differential osmosis, water will flow to the side with higher concentration, thereby reducing the water content of the Chinese herbal juice, increasing the concentration of harmful substances and improving detection sensitivity.

[0047] Example 3

[0048] The difference from the above embodiment is that the squeezing assembly 5 includes a second cylinder 18 , which is fixed to the top wall of the box body 1 by screws, and a lower pressure plate 19 is bolted to the output shaft of the second cylinder 18 .

[0049] The specific implementation process is as follows: after the output shaft of the second cylinder 18 is extended, the lower pressing plate 19 is pressed against the Chinese herbal medicine to squeeze out the juice in the Chinese herbal medicine, thereby facilitating the establishment of a liquid detection environment.

[0050] Example 4

[0051] The difference from the above embodiment is that a grinding wheel 20 is installed at the bottom of the lower pressing plate 19, and the grinding wheel 20 is connected to a first motor for driving the grinding wheel 20 to rotate. The model of the first motor is DZ058.

[0052] The specific implementation process is as follows: the grinding wheel 20 will grind the Chinese herbal medicine during the squeezing process, so that a large amount of juice can flow out, which is convenient for subsequent detection components to perform detection.

[0053] Example 5

[0054] The difference from the above embodiment is that a light shielding plate 21 is provided between the detection chamber 4 and the extraction chamber 3 , the light shielding plate 21 is bonded and fixed to the box body 1 , and a through opening is provided at the bottom of the light shielding plate 21 .

[0055] The specific implementation process is as follows: Natural light may enter the detection chamber 4 from the extraction chamber 3 and interfere with the color detection of the color collector 11. The light shield 21 can block the external natural light, so that only one light source 14 is contained in the detection chamber 4, thereby making the image color collected by the color collector 11 more accurate.

[0056] Example 6

[0057] The difference from the above embodiment is that a filter membrane 22 is bonded and fixed in the through opening.

[0058] The specific implementation process is as follows: Fine debris is generated during herbal grinding. These debris can adhere to the COFs adsorption plate 6 and affect its performance. The filter membrane 22 intercepts these debris, reducing their chance of entering the detection chamber 4. The opening 2 communicates with the extraction chamber 3, trapping the debris within the chamber and facilitating its removal by the user.

[0059] Example 7

[0060] The difference from the above embodiment is that a second motor 23 is fixed by screws on the bottom of the detection chamber 4 , and a stirring paddle 24 is welded and fixed on the output shaft of the second motor 23 .

[0061] The specific implementation process is as follows: The color reaction often combines with harmful substances to produce colored substances. When the COFs adsorption plate 6 is powered off, the electromagnetic force disappears, and the adsorption effect on harmful substances decreases. At this time, deionized water is injected, and the second motor 23 is turned on to generate a water vortex to flush the detection chamber 4 and COFs adsorption plate 6, cleaning them and reducing interference with subsequent detection.

[0062] Example 8

[0063] The difference from the above embodiment is that a display 25 is fixed to the outer side of the box body 1 with bolts, and the model of the display 25 is ZPC150.

[0064] The specific implementation process is as follows: the display 25 can display the initial image, the color image and the color difference value, so that the user can easily obtain the detection information and process.

[0065] The above is only an embodiment of the present invention. Common knowledge such as the known specific structures and characteristics in the scheme is not described in detail here. Ordinary technicians in the field are aware of all common technical knowledge in the technical field of the invention before the application date or priority date, can obtain all existing technologies in the field, and have the ability to apply conventional experimental means before that date. Ordinary technicians in the field can improve and implement this scheme in combination with their own abilities under the inspiration given by this application. Some typical known structures or known methods should not become obstacles for ordinary technicians in the field to implement this application. It should be pointed out that for those skilled in the art, without departing from the structure of the present invention, several variations and improvements can be made, which should also be regarded as the scope of protection of the present invention. These will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials, characterized by: The invention comprises a box body, an opening is provided on the box body, a squeezing chamber and a detection chamber are provided in the box body, the opening and the detection chamber are both connected to the squeezing chamber, and a squeezing component is provided in the squeezing chamber; A COFs adsorption plate is provided on the side wall of the detection chamber, a one-way valve is provided at the bottom of the detection chamber, a first cylinder is fixedly connected to the top wall of the detection chamber, a detection assembly is provided on the output shaft of the first cylinder, the detection assembly includes a color developer bottle, a nozzle is connected to the bottom of the color developer bottle, a color collector is fixedly connected to the outer side of the bottom of the color developer bottle, the color collector includes a controller box, a controller is provided in the controller box, a camera and a light source are fixedly connected to the side of the controller box close to the COFs adsorption plate, and a power supply is provided in the bottom wall of the box; The color collector is used to control the light source illumination and capture the initial image of the COFs adsorption plate through the camera when the output shaft of the first cylinder is extended, and to capture the color image of the COFs adsorption plate after the developer is sprayed by the nozzle, and to compare and calculate the color difference between the initial image and the color image; The COFs adsorption plate is made of a mixed solution of carbon source, trialdehyde phloroglucinol, oxalohydrazide, N,N-dimethylacetamide and dioxane, which is stirred by ultrasonic and reacted at 120°C in a reactor for 72 hours. The solid reactant is taken out and cleaned to remove surface burrs, and then cleaned and dried. The mass ratio of carbon source, trialdehyde phloroglucinol, oxalohydrazide, N,N-dimethylacetamide and dioxane is 1:1:0.4:20:100, and glucose is used as the carbon source.

2. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 1 is characterized in that: An osmotic cavity is provided on one side of the detection cavity, a semipermeable membrane is provided between the detection cavity and the osmotic cavity, and a high-concentration liquid layer is provided in the osmotic cavity.

3. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 2 is characterized in that: The squeezing component includes a second cylinder, which is fixedly connected to the top wall of the box body, and a lower pressure plate is fixedly connected to the output shaft of the second cylinder.

4. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 3 is characterized by: A grinding wheel is provided at the bottom of the lower pressing plate, and the grinding wheel is provided with a first motor for driving the grinding wheel to rotate.

5. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 4 is characterized in that: A light shielding plate is provided between the detection cavity and the extraction cavity, and a through opening is provided at the bottom of the light shielding plate.

6. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 5, characterized in that: A filter membrane is fixedly connected in the through port.

7. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 6, characterized in that: A second motor is provided at the bottom of the detection chamber, and a stirring paddle is fixedly connected to the output shaft of the second motor.

8. The rapid detection system for harmful substances in Chinese herbal medicines based on covalent organic framework materials according to claim 7, characterized in that: A display is fixedly connected to the outside of the box.

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