Total solid corneal surgery system under the guidance of SSOCT monitoring

Abstract

The present invention provides a total solid corneal surgery system under the guidance of SSOCT monitoring, and relates to the technical field of medical equipment. The total solid corneal surgery system under the guidance of SSOCT monitoring provided by the embodiment of the present invention combines a multi-wavelength medical laser system with SSOCT monitoring technology, and can provide real-time, high-resolution eye images during the operation. Based on the system, surgical operations can be performed more accurately to avoid errors and risks. In the embodiment of the present invention, through SSOCT monitoring, detailed eye anatomical structure information can be obtained, including corneal morphology, thickness and other parameters, so that the surgical process can be personalized according to the individual characteristics of the patient, improving the surgical effect and prognosis. The total solid corneal surgery system under the guidance of SSOCT monitoring can better control the risks during the operation by monitoring the eye condition in real time. Including the control of cutting depth, corneal structure stability and other aspects, it can minimize the risk of surgery.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of medical equipment, and in particular to a total solid corneal surgery system under the guidance of SSOCT monitoring. Background Art

[0002] According to data from the World Health Organization (WHO), in 2020, 1 billion people will have visual impairment that could be prevented or has yet to be resolved, including 65.2 million with cataracts and 69 million with glaucoma, and the prevention and treatment rates need to be improved. Cataracts account for 9% of the causes of blindness and glaucoma accounts for 10%, both of which are the main causes of blindness and visual impairment in the world. The number of ophthalmic beds in ophthalmic hospitals and health institutions in my country has continued to increase, which has directly promoted the demand for purchasing ophthalmic microscopes. Compared with foreign ophthalmic microscope products, domestic products have obvious price advantages, which is conducive to reducing the operating costs of hospitals and the medical costs of patients. However, in the field of high-end products, domestic products have a large competitive disadvantage in reputation and quality.

[0003] In the prior art, the eye is usually treated or diagnosed using instruments whose design is matched to the corresponding application purpose. For example, if refractive errors are to be corrected by laser surgery on the cornea, an instrument suitable for diagnosing the eye is first used, such as a slit lamp, an optical arrangement for three-dimensional measurement of the cornea, an arrangement for optical coherence tomography, etc. The results achieved using this diagnostic instrument are then used to determine the treatment measures, and the instruments available for treatment are selected and prepared. During treatment, before the surgery to correct refractive errors, a flap-shaped cover (deckel) called a "flap" is first constructed on the corneal surface with the help of a so-called "flap knife" laser (also known as a laser keratome, or in its mechanical variant known as a microkeratome), and the thickness of the flap-shaped cover is significantly smaller than the thickness of the cornea. In order to be able to produce this flap-shaped cover as accurately as possible, laser keratomes are used in the prior art, which produce pulse widths of less than 10 -12 s of therapeutic laser beam. As a result, a locally limited puncture (Durchbruch) with an extension of only a few micrometers is achieved in the cornea. By purposefully arranging a plurality of such punctures together, the desired "flap" can be constructed and made flippable. After the "flap" is created, another instrument is used to remove tissue from the exposed inner area of ​​the cornea in the flipped "flap" for the purpose of correcting refractive errors. The removal operation, in turn, needs to be carried out by introducing energy with the help of a pulsed therapeutic laser beam, which can come from an excimer laser. After the treatment, it is usually necessary to use a diagnostic instrument in order to be able to evaluate the treatment results and, if necessary, to arrange follow-up treatment.

[0004] It can be seen that during the treatment process, the sequence of instruments used for diagnosis or treatment of the eye must be carefully considered, in which in particular the identification data related to the patient, the diagnosis data and / or treatment data and the configuration data or protocol data and control signals related to the treatment must be considered, so that the doctor or user performing the treatment can make the necessary adjustments for the treatment or diagnosis on the instruments used respectively. The patient also needs to be repositioned due to different instruments, or the individual instruments need to be moved to align the patient's eye to be diagnosed or treated.

[0005] In the prior art, since the instruments used are usually separate from each other, it is necessary to transport the patient from one instrument to the next during the treatment. However, this alone does not guarantee the precise positioning necessary for treatment or diagnosis on the respective instrument. Since the geometric dimensions of the instruments are not coordinated with each other, it is necessary not only to transport the patient between the instruments, but also to adjust the patient's position according to the respective instrument design. Summary of the invention

[0006] Optical coherence tomography (Swept-Source Optical Coherence Tomography, SSOCT) is a non-contact imaging modality that detects backscattered photons from tissue with high sensitivity and micrometer-scale spatial resolution. The advent of SSOCT Fourier domain detection and the confirmation of its sensitivity advantage over time-domain techniques have facilitated the transition from real-time two-dimensional B-SCAN imaging to real-time three-dimensional volumetric imaging.

[0007] Based on this, an embodiment of the present invention proposes a total solid corneal surgery system under the monitoring and guidance of SSOCT, so as to realize the whole process of total solid corneal surgery through an integrated surgery system under the monitoring and guidance of SSOCT.

[0008] The first aspect of the embodiment of the present invention provides a total solid corneal surgery system under SSOCT monitoring and guidance, including: an SSOCT system and a multi-wavelength medical laser system, wherein the multi-wavelength medical laser system includes a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nano-laser, a beam compensator, a first laser transmission device, a first reflector, a second laser transmission device, a positioning laser device, an eye tracking system, and a surgical microscope, wherein the deep ultraviolet nano-laser generates a laser with a wavelength between 190 nanometers and 213 nanometers, and the femtosecond laser generates a laser with a wavelength between 800 nanometers and 1100 nanometers. The laser between 190 nanometers and 213 nanometers is transmitted to the first reflector via a first laser transmission device, and the laser between 800 nanometers and 1100 nanometers is transmitted to the first reflector via a large digital aperture focusing lens group; the laser passing through the first reflector is transmitted to the target position via a second laser transmission device, and the positioning laser device adjusts the position of the laser based on the eye tracking system and the surgical microscope; the laser between 190 nanometers and 213 nanometers is used for cutting the cornea; the laser between 800 nanometers and 1100 nanometers is used for cutting the middle layer of the cornea;

[0009] The SSOCT system acquires real-time eyeball images, outputs control signals based on the real-time eyeball images, and controls the operating parameters of various components in the multi-wavelength medical laser system.

[0010] Optionally, the deep ultraviolet nano laser generates a laser with a wavelength of 213 nanometers, the femtosecond laser generates a laser with a wavelength of 1053 nanometers, the first reflector reflects the 1053 nanometer laser and transmits the 213 nanometer laser in a first state, and the first reflector reflects the 213 nanometer laser and transmits the 1053 nanometer laser in a second state;

[0011] The SSOCT system acquires a real-time eye image, outputs a control signal based on the real-time eye image, and controls the relevant parameters of each component in the multi-wavelength medical laser system, including:

[0012] The SSOCT system acquires real-time eyeball images, outputs control signals based on the real-time eyeball images, controls the state of the first reflector, controls the working parameters of the femtosecond laser, and controls the working parameters of the deep ultraviolet nano-laser.

[0013] Optionally, the femtosecond laser is a high repetition rate femtosecond laser between 800 nanometers and 1100 nanometers.

[0014] Optionally, the deep ultraviolet laser is a 213-nanometer pulsed laser with five times the frequency of Nd:YAG, and the solid laser is frequency-converted to generate a deep ultraviolet pulsed laser with a wavelength between 190 nanometers and 213 nanometers.

[0015] Optionally, the first laser transmission device includes: a beam compensator, a reflector, a beam expander and a beam homogenizer.

[0016] Optionally, the second laser transmission device includes: an XY scanning mirror and a focusing lens.

[0017] Optionally, the femtosecond laser is a fiber laser, the pulse energy is 1 μJ, the pulse width is 300 fs, the pulse frequency is less than 4 MHz, and the cooling method is air cooling.

[0018] Optionally, the spot diameter of the laser generated by the fiber laser is 3 μm, the focusing energy is 150 nJ / pulse, and the focusing range is 300 μm.

[0019] The all-solid cornea surgery system under the guidance of SSOCT monitoring provided by the embodiment of the present invention combines the all-solid cornea surgery system with SSOCT monitoring technology, and can provide real-time, high-resolution eye images during the operation. Based on the system, surgical operations can be performed more accurately to avoid errors and risks. In the embodiment of the present invention, through SSOCT monitoring, detailed ocular anatomical structure information can be obtained, including corneal morphology, thickness and other parameters, so that the surgical process can be personalized according to the individual characteristics of the patient, improving the surgical effect and prognosis. The all-solid cornea surgery system under the guidance of SSOCT monitoring can better control the risks during the operation by monitoring the eye condition in real time. Including the control of cutting depth, corneal structure stability and other aspects, it can minimize the risk of surgery.

[0020] In the all-solid cornea surgery system under SSOCT monitoring and guidance provided by an embodiment of the present invention, the multi-wavelength medical laser system can control the state conversion of the first reflector under the monitoring and guidance of SSOCT, so that the first reflector reflects the 1053-nanometer laser and transmits the 213-nanometer laser, or reflects the 213-nanometer laser and transmits the 1053-nanometer laser. Thus, one instrument can achieve both precise corneal cutting with a 213-nanometer laser and cutting in the middle layer of the cornea with a 1053-nanometer laser. There is no need to use multiple instruments or transfer the patient during the treatment process, which can simplify the treatment process and improve treatment efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments of the present invention will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative labor.

[0022] Figure 1 A schematic structural diagram of a total solid corneal surgery system under SSOCT monitoring and guidance provided by an embodiment of the present invention is shown;

[0023] Figure 2 A schematic structural diagram of a multi-wavelength medical laser system in a total solid corneal surgery system under SSOCT monitoring and guidance provided by an embodiment of the present invention is shown. DETAILED DESCRIPTION

[0024] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0025] In an embodiment of the present invention, a total solid corneal surgery system under SSOCT monitoring and guidance is provided. Figure 1 As shown, it shows a schematic diagram of the structure of a total solid corneal surgery system under SSOCT monitoring and guidance provided by an embodiment of the present invention. Specifically, the system includes: an SSOCT system and a multi-wavelength medical laser system. In an embodiment of the present invention, a schematic diagram of the structure of a multi-wavelength medical laser system in a total solid corneal surgery system under SSOCT monitoring and guidance is also provided, as shown in FIG. Figure 2 As shown, specifically, the multi-wavelength medical laser system includes a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nano laser, a beam compensator, a first laser transmission device, a first reflector, a second laser transmission device, a positioning laser device, an eye tracking system, and a surgical microscope. The deep ultraviolet nano laser generates a laser with a wavelength between 190 nanometers and 213 nanometers, and the femtosecond laser generates a laser with a wavelength between 800 nanometers and 1100 nanometers. The laser between 190 nanometers and 213 nanometers is transmitted to the first reflector via the first laser transmission device, and the laser between 800 nanometers and 1100 nanometers is transmitted to the first reflector via the large digital aperture focusing lens group; the laser passing through the first reflector is transmitted to the target position via the second laser transmission device, and the positioning laser device adjusts the position of the laser based on the eye tracking system and the surgical microscope; the laser between 190 nanometers and 213 nanometers is used for cutting the cornea; the laser between 800 nanometers and 1100 nanometers is used for cutting the middle layer of the cornea.

[0026] The SSOCT system acquires real-time eyeball images, outputs control signals based on the real-time eyeball images, and controls the operating parameters of various components in the multi-wavelength medical laser system.

[0027] In an embodiment of the present invention, SSOCT is a non-invasive imaging technology for imaging ocular structures. It uses a laser light source to emit a beam of near-infrared light and generates a high-resolution eye image by measuring the reflection of the light beam. SSOCT can provide detailed information about ocular structures, such as the retina, vitreous body, optic nerve, and cornea. The SSOCT system uses a swept light source to provide faster imaging speed and higher resolution. The SSOCT system uses a swept light source to emit a series of wave packets to achieve higher speed and resolution.

[0028] In specific applications, the SSOCT system can provide real-time eye images to help doctors accurately locate surgical areas and structures and perform precise surgical planning and operations. It can also output control signals based on real-time eye images to control the working parameters of each component in the multi-wavelength medical laser system.

[0029] In an embodiment of the present invention, the SSOCT system avoids causing additional damage to the eye tissue while imaging at high speed. Specifically, SSOCT is a non-invasive imaging technology that uses optical principles for imaging and does not require direct contact with the eyeball or eye tissue. This means that during surgery, the SSOCT system will not directly cause physical damage to the eye tissue. In addition, the SSOCT system uses swept-frequency light source technology to provide faster imaging speeds. This means that the image acquisition time is very short, reducing the exposure time to the eye tissue, thereby reducing the risk of additional damage. In addition, the SSOCT system has the advantage of high resolution and can provide clear, detailed, high-resolution imaging of the eye. This enables doctors to observe the eye structure more accurately and avoid misoperation or unnecessary damage to the surrounding tissue. As a result, the SSOCT system ensures that additional damage to the eye tissue is avoided while imaging at high speed through non-invasive imaging, fast imaging, and high-resolution imaging, and can accurately guide the multi-wavelength medical laser system to cut the cornea and cut the middle layer of the cornea.

[0030] In an embodiment of the present invention, the SSOCT system can also provide real-time eye images, and the doctor can observe the eye structure through the monitoring screen during the operation. This enables the doctor to accurately locate the surgical area and structure and make adjustments in time. Specifically, the high-resolution imaging of the SSOCT system can clearly display the anatomical structure of the eye, including the retina, vitreous body, optic nerve and cornea. The doctor can understand the state and position of the eye tissue based on this image information, thereby guiding the surgical operation. The SSOCT system also has a guide marking and measurement function. The doctor can mark and measure on the image to help determine the surgical position and angle. These markings and measurements can provide quantitative references to make the surgical operation more accurate.

[0031] In the embodiment of the present invention, the SSOCT system can reconstruct a three-dimensional image of the eye structure, and the doctor can obtain a more comprehensive field of view by rotating and enlarging the image, which helps the doctor better understand the spatial relationship of the eye structure and perform more accurate surgical planning and operation.

[0032] In the embodiment of the present invention, the femtosecond laser may specifically be a high repetition rate femtosecond laser with a wavelength between 800 nanometers and 1100 nanometers.

[0033] In the embodiment of the present invention, the deep ultraviolet laser is a 213 nanometer pulsed laser with five times the frequency of Nd:YAG, and the solid laser can be used to generate a deep ultraviolet pulsed laser with a wavelength between 190 nanometers and 213 nanometers through frequency conversion technology.

[0034] In actual application, either 213 nanometer laser or deep ultraviolet nanometer laser can be selected.

[0035] In actual application, the first reflector has two states. In the first state, 213 nanometer laser can be transmitted to the second laser transmission device. In the second state, 1053 nanometer femtosecond laser can be transmitted to the second laser transmission device.

[0036] Optionally, the first reflector may reflect 1053 nm laser and transmit 213 nm laser in the first state, and the first reflector may reflect 213 nm laser and transmit 1053 nm laser in the second state.

[0037] In this case, in the actual application process, the first reflector can be set to the second state by default. At this time, even if one or more of the two lasers are started, the laser will not reach the eyeball position, which can avoid misoperation. During the operation of the operation, the femtosecond laser can be started first, and the first reflector can be set to the second state, so that the 1053-nanometer femtosecond laser generated by the femtosecond laser reaches the eyeball position through the reflection of the first reflector, and the precise cutting of the middle layer of the cornea is completed under the monitoring and guidance of SSOCT; under the monitoring and guidance of SSOCT, after determining that the cutting of the middle layer of the cornea is completed, a control signal is output to control the state of the first reflector, and the deep ultraviolet nano laser is started, so that the 213-nanometer laser generated by the deep ultraviolet nano laser is transmitted through the first reflector to reach the eyeball position, and the cornea is cut.

[0038] In the embodiment of the present invention, the eye tracking system can monitor the position and movement of the eye in real time to ensure that the laser is irradiated at the correct position. The eye tracking system can further help reduce errors in surgery and improve the accuracy and safety of surgery.

[0039] Optionally, the first state of the first reflector may be to transmit 213-nanometer laser light, and the second state may be to reflect 1053-nanometer laser light.

[0040] In this case, in actual application, the femtosecond laser can be controlled to start first, and the first reflector can be controlled to adjust to the reflection function, and the laser beam generated by the femtosecond laser can be reflected into the second laser transmission device through the first reflector, and finally transmitted to the eyeball to cut the middle layer of the cornea, and then the femtosecond laser can be controlled to turn off. The 213 nanometer laser or deep ultraviolet nano laser can be controlled to start, and the first reflector can be controlled to adjust to the transmission function, and the laser beam can be transmitted into the second laser transmission device through the first reflector, and finally transmitted to the eyeball to cut the cornea.

[0041] Specifically, the first reflector can be a lens with two sides having different curvatures, so that one side reflects the received light beam and the other side transmits the received light beam. In practical applications, the first reflector can be flipped and the angle adjusted to achieve the conversion of its two states.

[0042] Specifically, the first reflector may also be a lens system composed of a plurality of lenses, and the conversion between the two states may be achieved by adjusting parameters such as the number, position and curvature of the lenses.

[0043] In the embodiment of the present invention, the function of the large numerical aperture focusing lens group is to focus the light beam to a very small point or area. Such a lens group is usually composed of multiple lenses to achieve more complex optical functions.

[0044] Specifically, the functions of the large numerical aperture focusing lens group include:

[0045] High numerical aperture: A large numerical aperture means that the ratio between the diameter and focal length of the lens is large, which means that a wider range of incident light can be received. This design enables the focusing lens group to collect more light and can handle a larger incident angle, improving the light collection efficiency and the luminous flux of the lens system.

[0046] High resolution: A large numerical aperture focusing lens group can provide higher resolution, that is, it can focus light more clearly, making the size of the focus spot smaller. This is very important for applications that require high-precision imaging or high resolution, such as microscopy, laser inscription, and optical sensors.

[0047] Optical correction: The focusing lens group can correct optical distortion by combining lenses of different curvatures and shapes. This includes spherical aberration, chromatic aberration, and aberration. By optimizing the design and combination of lens groups, better optical performance can be achieved, and the image quality and clarity of the focus point can be improved.

[0048] Beam shape adjustment: The large numerical aperture focusing lens group can also adjust the shape of the beam through the shape and combination of lenses. For example, by using aspherical lenses or non-uniform lens curvature, the beam shape can be adjusted, such as converting a circular beam into an elliptical beam.

[0049] In the embodiment of the present invention, the second laser transmission device includes: an XY scanning mirror and a focusing lens.

[0050] In the embodiment of the present invention, the femtosecond laser is a fiber laser, the pulse energy is 1 μJ, the pulse width is 300 fs, the pulse frequency is less than 4 MHz, and the cooling method is air cooling.

[0051] In the embodiment of the present invention, the spot diameter of the laser generated by the fiber laser is 3 μm, the focusing energy is 150 nJ / pulse, and the focusing range is 300 μm.

[0052] In the embodiment of the present invention, the XY scanning mirror is a component commonly used in optical systems and laser technology. It is composed of two mutually perpendicular mirrors, one for the horizontal direction (X axis) and the other for the vertical direction (Y axis). By controlling the movement of the two mirrors, the laser beam can be accurately positioned and oriented. The main function of the XY scanning mirror is to change the direction and position of the light beam. By controlling the angle and speed of the scanning mirror, the light beam can be scanned, focused, deflected and positioned on a plane.

[0053] The focusing lens in the multi-wavelength medical laser system provided by the embodiment of the present invention can focus the light beam onto a smaller point or area. The focusing lens can change the propagation direction of the light beam and the intensity distribution of the light, making the light beam more concentrated and powerful.

[0054] Specifically, the focusing lens has the following functions:

[0055] Focusing: A focusing lens can focus a parallel incident light beam onto a focal point. By changing the relative position of the lens and the light beam or adjusting the curvature of the lens, the focal length of the light beam and the position of the focal point can be controlled.

[0056] Beam shape adjustment: The focusing lens can change the shape of the laser beam, for example, turning a circular beam into an elliptical beam.

[0057] Beam adjustment: The focusing lens can adjust the diameter and divergence of the beam. By changing the aperture and curvature of the lens, the degree of divergence or focusing of the beam can be controlled.

[0058] Optical correction: Focusing lenses can also be used to correct optical distortions in a light beam. For example, a spherical lens can correct spherical aberration, which allows the light beam to maintain better quality and sharpness of the focus point during the focusing process.

[0059] Specifically, in actual application, the working parameters of the large digital aperture focusing lens group, XY scanning mirror and focusing lens can be controlled based on the real-time eye image obtained by the SSOCT system to adjust the direction, position, diameter and divergence angle of the laser light beam reflected by the first reflector to meet the surgical needs.

[0060] In an embodiment of the present invention, a first laser transmission device includes: a beam compensator, a reflector, a beam expander and a beam homogenizer.

[0061] In the embodiment of the present invention, the beam compensator is a device for adjusting the focal point position of the laser beam inside the eye. Its function is to correct the error caused by the refraction of the light beam inside the eyeball due to factors such as corneal morphology and refractive power, to ensure that the laser can be accurately focused on the retina, thereby achieving accurate and effective treatment effects. In the embodiment of the present invention, the beam compensator can dynamically adjust the direction and intensity of the light beam to make corrections to the specific conditions of the patient's eyes at any time during the treatment process, thereby improving the accuracy and safety of the surgery. This technology can greatly reduce the risks of surgery, improve the success rate of surgery and the patient's treatment experience.

[0062] In the embodiment of the present invention, the beam expander is a device that can adjust and limit the diameter and shape of the 213 nm laser beam. The beam expander plays a role in focusing and controlling the laser beam so that it can accurately irradiate a specific part of the patient's eye, thereby achieving a precise treatment effect.

[0063] In the embodiment of the present invention, the beam expander can ensure the focus and accuracy of the laser beam, improve the safety and precision of the operation, and limit the diameter of the laser beam to a smaller range, so that it can be accurately focused on a specific area of ​​the eye, while also protecting the surrounding tissues from unnecessary damage to the greatest extent. By properly adjusting and using the beam expander, doctors can better control the intensity and focus range of the laser, thereby effectively performing various ophthalmic surgical treatments.

[0064] In the embodiment of the present invention, the beam expander can also help control the energy density of the laser to ensure that the laser produces an appropriate thermal effect in the eye tissue to achieve the desired therapeutic effect.

[0065] In the embodiment of the present invention, the beam expander is generally composed of high-quality optical elements, which can maintain the quality and stability of the laser beam.

[0066] In the embodiment of the present invention, the beam homogenizer can adjust the intensity distribution of the laser beam so that it can evenly cover the entire target area when treating the patient's eye tissue. This can ensure that the patient receives uniform laser energy and improve the accuracy and safety of the operation. The beam homogenizer is usually made of special optical design and materials to ensure that the laser beam can be effectively homogenized when passing through the device. In addition, the beam homogenizer can also help adjust the diameter and shape of the laser beam to meet different surgical needs.

[0067] In an embodiment of the present invention, during the application of a multi-wavelength medical laser system, a doctor can, based on the cooperation of an eye tracking system, obtain a real-time eye image under the observation of a surgical microscope and in combination with an SSOCT system, and control the working parameters of a beam compensator, a beam expander, and a beam homogenizer to adjust the shape, position, focus, and intensity of the laser beam to meet the needs of the patient.

[0068] In an embodiment of the present invention, the 213 nanometer laser or deep ultraviolet laser generated by the 213 nanometer laser or deep ultraviolet nanolaser can first be adjusted based on the cooperation of the beam compensator, the beam expander, and the beam homogenizer to obtain a laser beam that adapts to the actual situation of the patient. The laser beam is transmitted through the first reflector and then transmitted to the cornea of ​​the eyeball via the XY scanning mirror and the focusing lens, thereby completing corneal cutting.

[0069] In the embodiment of the present invention, during the transmission of the 213-nanometer laser beam, the relevant parameters of the XY scanning mirror and the focusing lens in the second laser transmission device can be fixed unchanged, and the relevant parameters of the beam compensator, the reflector, the beam expander and the beam homogenizer in the first laser transmission device can be adjusted so that the shape, position, focusing degree and intensity of the 213-nanometer laser beam meet actual requirements.

[0070] The multi-wavelength medical laser system provided in the embodiment of the present invention can reflect the laser generated by a femtosecond laser machine by a first reflector, and can also transmit the laser generated by a 213-nanometer or deep ultraviolet nano-laser. A single instrument can be used to cut the cornea using a 213-nanometer laser, and can also use a femtosecond solid laser to cut the middle layer of the cornea. During the treatment process, there is no need to use multiple instruments, and there is no need to transfer the patient, which can simplify the treatment process and improve treatment efficiency.

[0071] In the embodiment of the present invention, the SSOCT system can not only obtain real-time eye images during surgery, output control signals based on the real-time eye images, and control the working parameters of each component in the multi-wavelength medical laser system, but also provide detailed information on the anatomical structure of the eye during the pre-operative evaluation stage to assist doctors in surgical planning and pre-operative simulation, and can also be used to check surgical results and monitor patient recovery after surgery.

[0072] The embodiment of the present invention also provides a control method of a total solid corneal surgery system under SSOCT monitoring and guidance. Specifically, the method includes:

[0073] Step 1: Start the SSOCT system to obtain a real-time eyeball image, and output working parameters for the femtosecond laser, the large numerical aperture focusing lens group, and the second laser transmission device based on the real-time eyeball image;

[0074] Step 2: Control the femtosecond laser to start, and control the large numerical aperture focusing lens group and the XY scanning mirror and focusing lens in the second laser transmission device to operate according to the working parameters determined in step 1.

[0075] Step 3: Control the femtosecond laser to emit laser and cut the middle layer of the cornea.

[0076] Step 4: Control the femtosecond laser to turn off, control the deep ultraviolet nano laser to start, control the first reflector to switch the working state, and output the working parameters of the beam compensator, reflector, beam expander and beam homogenizer in the first laser transmission device based on the real-time eye image.

[0077] Step 5, controlling the deep ultraviolet nano-laser to emit laser to perform cutting on the cornea.

[0078] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

[0079] The above description of the invented aspects is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these aspects will be readily apparent to those skilled in the art, and the general principles defined herein may be applied to other aspects without departing from the scope of the present invention. Therefore, the present invention is not intended to be limited to the aspects shown herein, but rather to the widest scope consistent with the principles and novel features of the present invention.

[0080] The above description has been given for the purpose of illustration and description. In addition, this description is not intended to limit the embodiments of the present invention to the form invented herein. Although multiple example aspects and embodiments have been discussed above, those skilled in the art will recognize certain variations, modifications, changes, additions and sub-combinations thereof.

Claims

1. A total solid corneal surgery system under SSOCT monitoring and guidance, characterized in that: include: SSOCT system and multi-wavelength medical laser system, the multi-wavelength medical laser system includes a femtosecond laser, a large digital aperture focusing lens group, a deep ultraviolet nano laser, a beam compensator, a first laser transmission device, a first reflector, a second laser transmission device, a positioning laser device, an eye tracking system, and a surgical microscope, the deep ultraviolet nano laser generates a laser with a wavelength between 190 nanometers and 213 nanometers, the femtosecond laser generates a laser with a wavelength between 800 nanometers and 1100 nanometers, the laser between 190 nanometers and 213 nanometers is transmitted to the first reflector through the first laser transmission device, the laser between 800 nanometers and 1100 nanometers is transmitted to the first reflector through the large digital aperture focusing lens group; the laser passing through the first reflector is transmitted to the target position through the second laser transmission device, and the positioning laser device adjusts the position of the laser based on the eye tracking system and the surgical microscope; the laser between 190 nanometers and 213 nanometers is used for cutting the cornea; the laser between 800 nanometers and 1100 nanometers is used for cutting the middle layer of the cornea; The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls the operating parameters of each component in the multi-wavelength medical laser system; The deep ultraviolet nano laser generates a laser with a wavelength of 213 nanometers, the femtosecond laser generates a laser with a wavelength of 1053 nanometers, the first reflector reflects the 1053 nanometer laser and transmits the 213 nanometer laser in a first state, and the first reflector reflects the 213 nanometer laser and transmits the 1053 nanometer laser in a second state; The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, and controls the working parameters of each component in the multi-wavelength medical laser system, including: The SSOCT system acquires a real-time eyeball image, outputs a control signal based on the real-time eyeball image, controls the state of the first reflector, controls the working parameters of the femtosecond laser, and controls the working parameters of the deep ultraviolet nano-laser; During the application of the all-solid cornea surgery system, the first reflector is first set to the second state. At this time, even if one or more of the two lasers are started, the laser will not reach the eyeball position, thereby avoiding misoperation; during the operation of the surgery, the femtosecond laser is first started, and the first reflector is set to the second state, so that the 1053-nanometer femtosecond laser generated by the femtosecond laser reaches the eyeball position after being reflected by the first reflector, and precise cutting of the middle layer of the cornea is completed under the monitoring and guidance of SSOCT; under the monitoring and guidance of SSOCT, after determining that the cutting of the middle layer of the cornea is completed, a control signal is output to control the state of the first reflector, and the deep ultraviolet nanolaser is started, so that the 213-nanometer laser generated by the deep ultraviolet nanolaser is transmitted through the first reflector to reach the eyeball position, and the cornea is cut.

2. The total solid corneal surgery system under SSOCT monitoring and guidance according to claim 1, characterized in that: The femtosecond laser is a high repetition rate femtosecond laser between 800 nanometers and 1100 nanometers.

3. The total solid corneal surgery system under SSOCT monitoring and guidance according to claim 1, characterized in that: The deep ultraviolet nano laser is a 213 nanometer pulse laser with five times the frequency of Nd:YAG, and the frequency of the solid laser is converted to generate a deep ultraviolet pulse laser with a wavelength between 190 nanometers and 213 nanometers.

4. The multi-wavelength medical laser system according to claim 1, characterized in that: The first laser transmission device includes: a beam compensator, a reflector, a beam expander and a beam homogenizer.

5. The total solid corneal surgery system under SSOCT monitoring and guidance according to claim 1, characterized in that: The second laser transmission device includes: an XY scanning mirror and a focusing lens.

6. The all-solid corneal surgery system under SSOCT monitoring and guidance according to claim 1, characterized in that: The femtosecond laser is a fiber laser, with a pulse energy of 1 μJ, a pulse width of 300 fs, a pulse frequency of less than 4 MHz, and a cooling method of air cooling.

7. The total solid corneal surgery system under SSOCT monitoring and guidance according to claim 4, characterized in that: The spot diameter of the laser generated by the fiber laser is: 3μm, and the focusing energy is: 150nJ / pulse.

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