A traditional Chinese medicine formula capsule for treating diabetes

Abstract

A traditional Chinese medicine capsule for treating diabetes comprises the following raw materials by weight: 5-15 parts of ginseng, 20-60 parts of silkworm chrysalis, 25-75 parts of sweet marigold, 25-75 parts of mesona, 10-30 parts of emblic, 25-75 parts of ordes, 20-60 parts of green fruit, 20-60 parts of Chinese schima, 10-30 parts of loquat leaf, and 25-75 parts of winter hibiscus fruit. The components are reasonable, the compatibility is scientific, the components support each other, the capsule is safe for treating diabetes, the curative effect is stable and reliable, the effect is good when combined with western medicine, the side effect of the medicine can be effectively reduced, the treatment effect is consolidated, and the pain of long-term medication of patients is reduced. The preparation method is simple and easy to operate, the cost is low, and the social and economic benefits are huge.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medicine, in particular to a traditional Chinese medicine formula capsule for treating diabetes. BACKGROUND

[0002] Diabetes is a common disease caused by the interaction of genetic and environmental factors, and is clinically characterized by high blood sugar. Common symptoms include polydipsia, polyuria, polyphagia, and weight loss. Diabetes can cause damage to multiple systems of the body, causing absolute or relative insulin secretion deficiency and decreased insulin sensitivity of target tissue cells, leading to a series of metabolic disorder syndromes such as protein, fat, water and electrolyte. If diabetes is not effectively treated, it can cause damage to multiple systems of the body. Significant elevation of blood glucose can cause acute complications such as diabetic ketoacidosis and hyperosmolar coma, and prolonged illness can also cause vascular and neuropathic disorders, resulting in damage to multiple organ tissues such as heart, brain, kidney, eye, nerve and skin, affecting the quality of life of patients, and even leading to a shorter life span, which should be actively prevented and treated.

[0003] Currently, in the clinical treatment of diabetes, western medicine or insulin injection is often used to treat diabetes, which can control the disease to a certain extent, but the curative effect is not consolidated, and only the symptoms can be relieved, and the function of insulin cannot be fundamentally repaired. Moreover, long-term use of western medicine can cause drug resistance, and the dosage and type of medicine need to be adjusted regularly, and most of them have large side effects, and patients need to take medicine for a lifetime. Prolonged use of insulin produces antibodies, reduces biological activity, increases dosage, and causes high insulinemia, which promotes the occurrence and development of microvascular disease. Traditional Chinese medicine treatment of diabetes focuses on overall regulation, and is superior to western medicine in improving symptoms and other aspects. The hypoglycemic effect is mild and stable, and the effect on the prevention and treatment of chronic complications of diabetes is significant. There are various types of traditional Chinese medicines on the market, but the effects are uneven and unsatisfactory. Most of the drug components are complex and can easily cause burden to the gastrointestinal tract. Therefore, a traditional Chinese medicine needs to be developed to reduce drug side effects, consolidate treatment effect, and reduce the pain of long-term medication for patients, but no public report has been found so far. SUMMARY

[0004] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present application is to provide a traditional Chinese medicine formula capsule for treating diabetes, which can effectively solve the problems of large drug side effects, long cycle, slow curative effect and unstable effect of the existing drugs for treating diabetes.

[0005] To achieve the above-mentioned purpose, the technical solution solved by the present application is a traditional Chinese medicine formula capsule for treating diabetes, which comprises the following raw materials by weight: 5-15 parts of ginseng, 20-60 parts of silkworm chrysalis, 25-75 parts of sweetleaf, 25-75 parts of mesona, 10-30 parts of emblic, 25-75 parts of orodes, 20-60 parts of green fruit, 20-60 parts of albizia, 10-30 parts of loquat leaf, and 25-75 parts of winter holly fruit.

[0006] Wherein, (1), first rinse ginseng, silkworm chrysalis with water, place in the oven 75-85 ℃ drying, ginseng, silkworm chrysalis mixed, placed in the pulverizer, crush, 120 mesh sieve, 115-130 ℃ sterilization 20-40 min, get the medicine powder, for future use;

[0007] (2) sweet leaf chrysanthemum, cold noodles grass, emblic, reed four raw medicinal materials are added water decoct twice, first time to add four raw medicinal materials weight 8-10 times the amount of water, decoct 1.5-2.5 h;Filter, get the first filtrate, the residue is added four raw medicinal materials weight 6-8 times the amount of water, decoct 1-1.5 h, filter, get the second filtrate, combine two filtrates;Concentrated to 80-90 ℃ relative density 1.25-1.40 thick paste under reduced pressure, get water extract thick paste;

[0008] (3) mix green fruit, sweet-scented tree bark, loquat leaf, winter hibiscus fruit, add four raw medicinal materials 6-8 times the volume concentration 60-80% ethanol, heated to 70-80 ℃, reflux extraction 2-3 times, 1-2 h each time, combine the extract, filter, recover ethanol under reduced pressure, concentrated to 70-80 ℃ relative density 1.25-1.40 thick paste, get alcohol extract thick paste;

[0009] (4) mix water extract thick paste and alcohol extract thick paste evenly, vacuum drying 2-3 h, crush, 80 mesh sieve, get thick paste powder;

[0010] (5) mix thick paste powder with ginseng, silkworm chrysalis medicine powder evenly, granulation, the prepared granules are placed in the fluid bed dryer, 60-80 ℃ drying 2-3 h, get dry granules;

[0011] (6) add 1% magnesium stearate to the dry granules, mix evenly, fill the capsules, each capsule contains 0.4 g, thus obtained.

[0012] The components of the application are reasonable, the compatibility is scientific, the components support each other, the application is used for treating diabetes, the medication is safe, the curative effect is stable and reliable, the effect is good when combined with western medicine, the drug side effects can be effectively reduced, the treatment effect is consolidated, and the pain of long-term medication of patients is reduced. The preparation method is simple and easy to operate, the cost is low, and the social and economic benefits are huge. DETAILED DESCRIPTION

[0013] The specific embodiments of the application will be described in detail below in combination with examples and specific cases.

[0014] The application is implemented in the following examples. EXAMPLE

[0015] A traditional Chinese medicine formula capsule for treating diabetes, comprising the following raw materials by weight: 5 parts of ginseng, 20 parts of silkworm chrysalis, 25 parts of stevia, 25 parts of mesona, 10 parts of emblic, 25 parts of ordu root, 20 parts of green fruit, 20 parts of albizzia, 10 parts of loquat leaf, 25 parts of winter hibiscus fruit;

[0016] Wherein, (1), first wash ginseng and silkworm chrysalis with water, dry in an oven at 75℃, mix ginseng and silkworm chrysalis, crush in a crusher, pass through a 120 mesh sieve, sterilize at 120℃ for 30 minutes, obtain a medicine powder, and reserve for use;

[0017] (2) decoct the four raw medicinal materials of stevia, mesona, emblic and ordu root twice, add 8 times the weight of water to the four raw medicinal materials for the first time, decoct for 2.5 hours; filter to obtain the first filtrate, add 8 times the weight of water to the medicinal residue for the second time, decoct for 1 hour, filter to obtain the second filtrate, and combine the two filtrates; reduce the pressure to concentrate to a thick paste with a relative density of 1.25 at 80℃, and obtain a water-extracted thick paste;

[0018] (3) mix the four raw medicinal materials of green fruit, albizzia, loquat leaf and winter hibiscus fruit, add 6 times the weight of the four raw medicinal materials with 60% volume concentration of ethanol, heat to 70℃, reflux extract twice, 1.5 hours each time, combine the extract, filter, reduce the pressure to recover ethanol, and concentrate to a thick paste with a relative density of 1.25 at 70℃, and obtain an alcohol-extracted thick paste;

[0019] (4) mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 3 hours, crush, and pass through an 80 mesh sieve to obtain a thick paste powder;

[0020] (5) mix the thick paste powder with the ginseng and silkworm chrysalis medicine powder evenly, granulate, and place the prepared granules in a fluid bed dryer, dry at 60℃ for 3 hours to obtain dry granules;

[0021] (6) add 1% of magnesium stearate by weight of the dry granules, mix evenly, and fill into capsules, 0.4g per capsule, and obtain the product. Example

[0022] A traditional Chinese medicine formula capsule for treating diabetes, comprising the following raw materials by weight: 10 parts of ginseng, 40 parts of silkworm chrysalis, 50 parts of stevia, 50 parts of mesona, 20 parts of emblic, 50 parts of ordu root, 40 parts of green fruit, 40 parts of albizzia, 20 parts of loquat leaf, and 50 parts of winter hibiscus fruit;

[0023] Wherein, (1), first wash ginseng and silkworm chrysalis with water, dry in an oven at 85℃, mix ginseng and silkworm chrysalis, crush in a crusher, pass through a 120 mesh sieve, sterilize at 115℃ for 40 minutes, obtain a medicine powder, and reserve for use;

[0024] (2) add water to the four raw medicinal materials of stevia, gynura, emblic, and reed root, and decoct twice, the first time by adding 9 times the weight of water to the four raw medicinal materials, and decocting for 2 hours; filter to obtain the first filtrate, add 7 times the weight of water to the residue to the four raw medicinal materials, and decoct for 1.5 hours, filter to obtain the second filtrate, and combine the two filtrates; reduce the pressure to concentrate to a thick paste with a relative density of 1.30 at 85°C, and obtain the water-extracted thick paste;

[0025] (3) mix the four raw medicinal materials of green fruit, Chinese scholartree bark, loquat leaf, and winter hibiscus fruit, add 7 times the weight of the four raw medicinal materials of 70% ethanol, heat to 80°C, and reflux extract twice, 1.5 hours each time, combine the extract, filter, reduce the pressure to recover the ethanol, and concentrate to a thick paste with a relative density of 1.30 at 80°C, and obtain the alcohol-extracted thick paste;

[0026] (4) mix the water-extracted thick paste and the alcohol-extracted thick paste, vacuum dry for 2.5 hours, crush, and pass through an 80-mesh sieve to obtain the thick paste powder;

[0027] (5) mix the thick paste powder with the medicinal powders of ginseng and silkworm chrysalis, granulate, and place the prepared granules in a fluid bed dryer, dry at 70°C for 3 hours, and obtain the dry granules;

[0028] (6) add 1% of magnesium stearate to the weight of the dry granules, mix, and fill into capsules, 0.4g per capsule, and obtain the product. Embodiment

[0029] A traditional Chinese medicine formula capsule for treating diabetes, comprising the following raw materials by weight: ginseng 15 parts, silkworm chrysalis 60 parts, stevia 75 parts, gynura 75 parts, emblic 30 parts, reed root 75 parts, green fruit 60 parts, Chinese scholartree bark 60 parts, loquat leaf 30 parts, and winter hibiscus fruit 75 parts;

[0030] Among them, (1) first wash ginseng and silkworm chrysalis with water, dry in an oven at 80°C, mix ginseng and silkworm chrysalis, crush in a crusher, pass through a 120-mesh sieve, sterilize at 130°C for 20 minutes, and obtain medicinal powder for standby;

[0031] (2) add water to the four raw medicinal materials of stevia, gynura, emblic, and reed root, and decoct twice, the first time by adding 10 times the weight of water to the four raw medicinal materials, and decocting for 1.5 hours; filter to obtain the first filtrate, add 6 times the weight of water to the residue to the four raw medicinal materials, and decoct for 1.5 hours, filter to obtain the second filtrate, and combine the two filtrates; reduce the pressure to concentrate to a thick paste with a relative density of 1.40 at 90°C, and obtain the water-extracted thick paste;

[0032] (3) mix the four raw medicinal materials of green fruit, Chinese scholartree bark, loquat leaf, and winter hibiscus fruit, add 8 times the weight of the four raw medicinal materials of 80% ethanol, heat to 80°C, and reflux extract three times, 1 hour each time, combine the extract, filter, reduce the pressure to recover the ethanol, and concentrate to a thick paste with a relative density of 1.40 at 75°C, and obtain the alcohol-extracted thick paste;

[0033] (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2 hours, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder;

[0034] (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 80°C for 2 hours to obtain dry granules;

[0035] (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each capsule containing 0.4g. Example

[0036] A traditional Chinese medicine capsule for treating diabetes includes the following ingredients by weight: 10 parts ginseng, 25 parts silkworm pupa, 50 parts stevia, 25 parts geranium, 15 parts amla, 50 parts reed rhizome, 50 parts green plum, 30 parts albizia bark, 15 parts loquat leaf, and 30 parts mallow fruit.

[0037] Among them, (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 80°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 118°C for 35 minutes, and obtain the powder for later use.

[0038] (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. Add water to the first decoction twice. Add water to the first decoction twice. Add water to the residue twice. Add water to the residue twice. Decoction for 1 hour. Filter to obtain the second decoction. Combine the two decoctions. Concentrate under reduced pressure to a thick paste with a relative density of 1.35 at 80℃ to obtain a water-extracted thick paste.

[0039] (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 8 times the weight of the four raw materials with 75% ethanol, heat to 75°C, reflux extract twice, 2 hours each time, combine the extracts, filter, recover the ethanol under reduced pressure, and concentrate to a thick paste with a relative density of 1.28 at 70°C to obtain the alcohol-extracted thick paste.

[0040] (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2.5 h, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder;

[0041] (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 65°C for 2.5 h to obtain dry granules;

[0042] (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each capsule containing 0.4g. Example

[0043] A traditional Chinese medicine capsule for treating diabetes includes the following ingredients by weight: 12 parts ginseng, 30 parts silkworm pupa, 40 parts stevia, 50 parts geranium, 20 parts amla, 40 parts reed rhizome, 40 parts green plum, 20 parts albizia bark, 20 parts loquat leaf, and 40 parts mallow fruit.

[0044] (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 75°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 125°C for 25 minutes, and obtain the powder for later use.

[0045] (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. For the first decoction, add water equal to 10 times the weight of the four raw materials and decoct for 2.5 h. Filter to obtain the first filtrate. Add water equal to 7 times the weight of the four raw materials to the residue and decoct for 1.5 h. Filter to obtain the second filtrate. Combine the two filtrates and concentrate under reduced pressure to a thick paste with a relative density of 1.28 at 90℃ to obtain a water-extracted thick paste.

[0046] (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 7 times the weight of the four raw materials with 75% ethanol, heat to 75°C, reflux extract 3 times, 1.5 h each time, combine the extracts, filter, recover the ethanol under reduced pressure, concentrate to a thick paste with a relative density of 1.35 at 80°C, and obtain the alcohol-extracted thick paste.

[0047] (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2.5 h, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder;

[0048] (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 75°C for 2 hours to obtain dry granules.

[0049] (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each capsule containing 0.4g.

[0050] Of the above-mentioned drugs,

[0051] Ginseng: Sweet, slightly bitter, slightly warm. It enters the spleen, lung, heart, and kidney meridians. It greatly replenishes vital energy, restores the pulse and consolidates the body, tonifies the spleen and lungs, generates fluids and nourishes blood, calms the mind and improves intelligence. It is used for weakness and impending collapse, cold limbs and weak pulse, spleen deficiency with poor appetite, lung deficiency with cough and asthma, thirst due to fluid depletion, internal heat and thirst, deficiency of qi and blood, chronic illness and emaciation, palpitations and insomnia, impotence and cold extremities.

[0052] Pharmacological studies have shown that ginseng has the following effects:

[0053] 1. Regulates the central nervous system: Ginseng can regulate the central nervous system, improve the excitation and inhibition processes of the brain, and bring them into balance; it can enhance mental and physical labor capacity, increase work efficiency, and has an anti-fatigue effect;

[0054] 2. Promotes the brain's utilization of energy substances: The effective components in ginseng that enhance learning and memory are ginsenosides, among which ginsenosides Rb1 and Rg1 have a good effect on learning and memory functions.

[0055] 3. Improves heart function: Ginseng can increase myocardial contractility, slow heart rate, increase cardiac output and coronary blood flow, and can resist myocardial ischemia and arrhythmia;

[0056] 4. Blood sugar lowering effect: Ginseng contains ginsenosides and ginseng polysaccharides. In particular, ginsenoside Rb2 has a significant blood sugar lowering effect. In addition, ginseng polysaccharides (or glycopeptides) are another type of blood sugar lowering component in ginseng.

[0057] 5. Enhance the body's immune function: Ginsenosides and ginseng polysaccharides are the active ingredients of ginseng that regulate immune function. They can improve immune function not only for normal people but also for people with low immune function.

[0058] 6. Enhances resistance to harmful stimuli: Ginseng contains ginsenosides, which can enhance the body's stress response and adaptability. It can improve resistance to hypoxia, high temperatures, and low temperatures.

[0059] 7. Anti-tumor effects: Ginseng contains ginsenosides, ginseng polysaccharides, ginsenosides, ginsenoside triols, and volatile oils. These substances have a certain inhibitory effect on tumors, but the mechanism is very complex.

[0060] 8. Antioxidant effects: Ginseng contains various antioxidants, such as ginsenosides, ginsenoside polyacetylenes, and ginsenoside diols. These compounds have anti-lipid peroxidation effects, which are the basis for anti-aging effects.

[0061] Silkworm pupae: Sweet, pungent, and salty; slightly warm. Enters the spleen, stomach, liver, and kidney meridians. Promotes the production of body fluids and quenches thirst, aids digestion and regulates qi. Used for diabetes, emaciation, and infantile malnutrition.

[0062] Pharmacological studies have shown that silkworm pupae have the following effects:

[0063] 1. Promotes salivation and quenches thirst: Silkworm pupae have the effect of promoting salivation and quenching thirst. Eating them in moderation can promote the secretion of saliva and relieve symptoms such as dry mouth and thirst.

[0064] 2. Strengthens the spleen and aids digestion: Silkworm pupae have the effect of strengthening the spleen and aiding digestion. Eating them in moderation can improve the digestive function of the gastrointestinal tract and alleviate symptoms such as hiccups and indigestion.

[0065] 3. Boost immunity: Silkworm pupae are rich in nutrients such as protein, vitamins and unsaturated fatty acids. Eating them in moderation can supplement the body with nutrients and boost the body's immunity.

[0066] 4. Silkworm pupae are rich in bioactive peptides, which have effects such as lowering blood pressure, inhibiting platelet aggregation, and promoting gastrointestinal motility. Bioactive peptides can also enhance the body's immunity, inhibit tumor cell growth, and have certain preventive and adjunctive therapeutic effects on diseases such as diabetes and hyperlipidemia.

[0067] Stevia: Sweet, neutral. Enters the stomach and lung meridians. Promotes the production of body fluids and quenches thirst, nourishes yin and subdues yang. Used for diabetes and dizziness.

[0068] Pharmacological studies have shown that stevia has the following effects:

[0069] 1. Hypoglycemic effect. Stevia components such as stevia extract inhibit glucose synthesis and oxygen absorption in the renal cortical tubules of rats. Stevia extract also inhibits the effects of atractylodes glycosides on energy metabolism; under the action of stevia extract, atractylodes glycosides reduce glycolysis, gluconeogenesis, glycogenolysis, and oxygen absorption.

[0070] 2. Vasodilatory effect. In normal or renal hypertensive rats, dandelionin caused a decrease in blood pressure, increased diuresis and urinary sodium excretion, and increased renal blood flow and glomerular filtration rate, partly due to arteriolar dilation.

[0071] Mesona chinensis: astringent, sweet, and cold in nature. It clears heat and quenches thirst, removing heat toxins. Used for heatstroke, high blood pressure, and diabetes.

[0072] Pharmacological studies have shown that *Mesona chinensis* has the following effects:

[0073] 1. Clearing heat and relieving summer heat: In traditional Chinese medicine, grass jelly is considered to be a sweet, bland, and cold herb or food. Grass jelly has a good effect of relieving summer heat, and is a cooling and thirst-quenching agent. It can clear heat and detoxify, and has a good effect of cooling blood.

[0074] 2. Detoxification and swelling reduction: Mesona chinensis has the effect of detoxification and swelling reduction, and can treat burns, toothache caused by wind and fire, erysipelas, syphilis and lacquer allergy, etc.

[0075] 3. Diuretic and jaundice-reducing: Mesona chinensis can be used to treat diabetes and is beneficial for patients with jaundice. Mesona chinensis can also be used to treat diarrhea and dysentery, and is beneficial for joint pain or acute nephritis.

[0076] Phyllanthus emblica: Sweet, sour, astringent, and cool in nature. It enters the lung and stomach meridians. It clears heat and cools the blood, aids digestion and strengthens the stomach, promotes the production of body fluids and relieves cough. It is used for blood heat and blood stasis, indigestion, abdominal distension, cough, sore throat, and dry mouth.

[0077] Pharmacological studies have shown that Phyllanthus emblica has the following effects:

[0078] 1. Antibacterial and antiviral effects: In traditional Chinese medicine, it is used to treat colds, fevers, and upper respiratory tract infections. Currently, throat lozenges made from Phyllanthus emblica can treat acute and chronic pharyngitis and coughs. Furthermore, Phyllanthus emblica can inhibit hepatitis B virus and has liver-protective effects.

[0079] 2. Antioxidant and anti-aging effects: Phyllanthus emblica contains a variety of antioxidants, including vitamin C, tannins, vitamin E, and superoxide dismutase.

[0080] 3. Anti-cancer and cancer-preventive effects: Studies have found that Phyllanthus emblica juice can effectively block the synthesis of N-nitroso compounds both in vivo and in vitro, thus exhibiting anti-cancer and cancer-preventive effects.

[0081] 4. Lipid-lowering and weight-loss effects: Li Shizhen recorded in the "Compendium of Materia Medica" that amla fruit has the effect of "lightening the body and prolonging life with long-term consumption". Modern pharmacological research shows that amla fruit can effectively lower blood cholesterol and triglycerides, treat simple obesity, and has a certain antihypertensive effect;

[0082] 5. Blood sugar lowering and improvement of diabetic complications: The blood sugar lowering effect of Phyllanthus emblica may be related to its flavonoids and sterols, various organic acids, and trace elements such as chromium, germanium, zinc, and selenium. Animal experiments have shown that it can increase glycogen levels, which is beneficial for regulating blood sugar.

[0083] Reed rhizome: Sweet, cold. Enters the lung and stomach meridians. Clears heat and drains fire, generates fluids and quenches thirst, relieves irritability, stops vomiting, and promotes urination. Used for feverish thirst, cough due to lung heat, lung abscess with purulent sputum, vomiting due to stomach heat, and painful urination due to heat.

[0084] Pharmacological studies have shown that reed rhizome has the following effects:

[0085] 1. Analgesic and antipyretic effects: The coixol contained therein has an analgesic effect in the rat tail electrical stimulation test, and the intensity is similar to that of aminopyrine;

[0086] 2. Central nervous system depressant effect: It has a weak central nervous system depressant effect, which is manifested in its sedative effect on rats and mice and its ability to antagonize caffeine;

[0087] 3. Antibacterial effect: It has varying degrees of antibacterial effect against Staphylococcus aureus, Moraxella catarrhalis, Corynebacterium diphtheriae, Shigella flexneri, Salmonella typhi, Salmonella paratyphi A, and Streptococcus pyogenes.

[0088] 4. Anti-inflammatory effect: Different doses of the decoction of reed rhizome can significantly reduce xylene-induced ear swelling in mice, thus exhibiting anti-inflammatory effects.

[0089] 5. Effects on Diabetes: The ethanol extract of reed rhizome has a certain ameliorative effect on the metabolic disorders of trace elements in diabetic mice. The ethanol extract of reed rhizome has a certain ameliorative effect on mitochondrial oxidative stress changes in the liver of diabetic mice, and reed rhizome polysaccharides can improve glucose tolerance and lower blood sugar.

[0090] Green plum: Sweet, sour, neutral. Enters the lung and stomach meridians. Clears heat and detoxifies, soothes the throat, and promotes saliva production. Used for sore throat, cough with sticky phlegm, feverish thirst, and fish / crab poisoning.

[0091] Pharmacological studies have shown that green plums have the following effects:

[0092] The extract of Terminalia chebula has a protective effect against hepatocellular poisoning caused by galactosamine; it can also alleviate liver damage caused by carbon tetrachloride. This product can also stimulate the salivary glands, increasing saliva secretion, thus aiding digestion.

[0093] Albizia bark: Sweet, neutral. Enters the heart, liver, and lung meridians. Relieves depression and calms the mind, invigorates blood circulation and reduces swelling. Used for restlessness, depression, insomnia, lung abscess, sores, and injuries from falls.

[0094] Pharmacological studies have shown that Albizia bark has the following effects:

[0095] 1. Albizia bark has the effect of relieving depression and calming the mind. The *Shennong Bencao Jing* records that Albizia bark primarily soothes the five internal organs and the mind, bringing joy and freedom from worry; long-term use can even lead to suicidal thoughts.

[0096] 2. Albizia bark has anti-allergic properties and can effectively reduce the occurrence of various allergy symptoms, making it especially suitable for people with allergies.

[0097] 3. Albizia bark has anti-inflammatory and antibacterial effects, and can be used to treat bacterial liver abscess and lung abscess, among other diseases.

[0098] 4. Albizia bark has the effects of promoting blood circulation and reducing swelling. Clinically, it can be used for traumatic injuries, fractures, blood stasis, and swelling pain.

[0099] Loquat leaf: Bitter, slightly cold. Enters the lung and stomach meridians. Clears the lungs and stops cough, relieves nausea and vomiting. Used for cough due to lung heat, shortness of breath, vomiting due to stomach heat, and thirst due to fever.

[0100] Pharmacological studies have shown that loquat leaves have the following effects:

[0101] 1. Antitussive, expectorant, and antiasthmatic effects: The amygdalin contained in this product produces hydrocyanic acid through hydrolysis in the body, which has an antitussive effect. The decoction or ethyl acetate extract has expectorant and antiasthmatic effects.

[0102] 2. Antibacterial effect: The decoction or ethyl acetate extract of this product has antibacterial effect against Staphylococcus aureus, Streptococcus pneumoniae, and Shigella flexneri.

[0103] 3. Nutritional Supplement: Loquat contains a variety of nutrients, which can effectively supplement the body's nutritional components, improve the body's disease resistance, and play a role in strengthening the body;

[0104] 4. Soothes the lungs and relieves cough: Loquat seeds contain amygdalin, which can relieve cough and expectorate phlegm, and treat various types of cough;

[0105] 5. Relieves nausea and vomiting: Loquat leaves have a cooling and bitter nature, and can relieve nausea and vomiting. They are an excellent remedy for vomiting and vomiting and can treat various types of vomiting and hiccups.

[0106] 6. Lowers blood sugar.

[0107] Malva verticillata fruit: sweet, astringent, and cooling. It clears heat, promotes urination, and reduces swelling. Used for urinary retention, edema, thirst, and urinary tract infections.

[0108] Pharmacological studies have shown that mallow fruit has the following effects:

[0109] 1. Cooling the blood and detoxifying: Malva berries can clear heat, cool the blood, drain pus, detoxify, and promote tissue regeneration. They can be used for various infections caused by heat toxicity.

[0110] 2. Clearing heat and draining pus: Malva nut clears heat and drains pus, and is used for intestinal abscess, i.e., appendicitis;

[0111] 3. Diuretic and urinary tract relieving effects: Malva berries are sweet, cold, and slippery, and have the effect of promoting urination and relieving urinary tract tract relieving effects;

[0112] 4. Promotes bowel movement: The fruit of winter mallow is smooth and moist, which helps to promote bowel movement.

[0113] This invention relates to a traditional Chinese medicine formula capsule for treating diabetes, in which each herbal ingredient forms an organic whole, and none can be omitted. During the prescription screening process, it was found that reducing any one of the ingredient components in the above composition, or replacing the ingredient components of the drug composition with an ingredient having similar medicinal properties, significantly reduced the efficacy of the drug combination; further adding other ingredient components to this composition did not significantly improve the overall effect of the composition.

[0114] The above-mentioned combination of drugs is scientifically sound and rationally formulated, providing effective treatment with good efficacy. It can effectively increase glucose transport, accelerate glucose oxidation and glycolysis, promote glycogen synthesis and storage, inhibit glycogenolysis and gluconeogenesis, thereby lowering blood sugar. It also has a good effect on recurrent infections, difficulty urinating, upper body obesity, skin itching, and weakened or absent tendon reflexes caused by diabetes. Ginseng is the principal ingredient in the formula, greatly replenishing vital energy, generating fluids and nourishing blood, stimulating pancreatic tissue to secrete insulin, and repairing damaged pancreatic β cells. Reed rhizome, loquat leaf, and silkworm pupa are the assistant ingredients, improving glucose tolerance and lowering blood sugar levels. Stevia leaf, amla fruit, green fruit, mesona fruit, and mallow fruit are the adjuvant ingredients, generating fluids and quenching thirst, promoting diuresis and relieving jaundice, improving diabetes symptoms. Albizia bark is the guiding ingredient, reducing mental depression caused by diabetic complications and calming the mind.

[0115] As can be seen from the above, the present invention provides a traditional Chinese medicine formula capsule for treating diabetes, which combines the theoretical basis of traditional Chinese medicine, emphasizes syndrome differentiation and treatment, and has a scientifically formulated prescription. Clinical trials have shown that it has achieved very good and beneficial technical effects, effectively reducing drug side effects, consolidating therapeutic effects, and reducing the suffering of patients from long-term medication. Taking Example 1 as an example, the relevant clinical data are as follows:

[0116] I. Case Selection:

[0117] 1.1 Case inclusion and exclusion criteria:

[0118] Inclusion criteria: Based on the Western medicine diagnostic criteria of the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine Drugs": fasting blood glucose exceeding 7.0 mmol / L, postprandial blood glucose greater than 11.1 mmol / L, and random blood glucose ≥11.1 mmol / L are diagnosed as diabetes. Those without typical symptoms of diabetes need to be re-examined on another day for confirmation and sign an informed consent form.

[0119] Exclusion criteria: pregnant or lactating women; those allergic to the investigational drug; those with other serious primary diseases; those with severe liver or kidney dysfunction; those with acute metabolic disorders such as diabetic ketoacidosis or concurrent infections within the past month; patients with vitamin B12, folic acid, and iron deficiency; and patients with poor general condition (such as malnutrition or dehydration).

[0120] 1.2 Selected Cases:

[0121] This efficacy observation was conducted on 138 patients diagnosed with diabetes and who gave informed consent. Among them, 61% were male. The researchers randomly divided the patients into a treatment group (n=70, including 43 males and 27 females, aged 35-65 years) and a control group (n=68, including 42 males and 26 females, aged 35-67 years). There were no significant differences between the two groups in terms of gender and age.

[0122] II. Treatment Plan:

[0123] Control group: Basic treatment: dietary control, scientific exercise guidance, and diabetes education. Drug treatment: Metformin hydrochloride tablets, orally, 0.5g / time, 3 times / day, dosage adjusted according to the patient's blood glucose level. One month constitutes one course of treatment, and efficacy is assessed after two courses of treatment.

[0124] Treatment group: Basic treatment: dietary control, scientific exercise guidance, and diabetes education. Drug treatment: 5 capsules of the traditional Chinese medicine formula prepared in Example 1 of this invention, dissolved in warm water, 3 times a day. One month constitutes one course of treatment, and efficacy is assessed after two courses.

[0125] III. Efficacy Evaluation Criteria:

[0126] Significant effect: Fasting blood glucose and 2-hour postprandial blood glucose levels decrease to the normal range; or fasting blood glucose and 2-hour postprandial blood glucose levels decrease by more than 40% of the pre-treatment levels, and glycated hemoglobin levels decrease to the normal range, or decrease by more than 30% of the pre-treatment levels;

[0127] Effective: Fasting blood glucose and 2-hour postprandial blood glucose decreased by more than 20% of the pre-treatment level, but did not meet the criteria for marked effectiveness; Glycated hemoglobin level decreased by more than 10% of the pre-treatment level, but did not meet the criteria for marked effectiveness.

[0128] Ineffective: Fasting blood glucose and 2-hour postprandial blood glucose do not decrease, or the decrease does not meet the effective standard; glycated hemoglobin does not decrease, or the decrease does not meet the effective standard.

[0129] Note: The efficacy rate is based on the standards in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial Implementation)". The total efficacy rate = (number of cases with significant effect + number of cases with effect) / total number of cases * 100%. Fasting blood glucose and 2-hour postprandial blood glucose were used to evaluate the efficacy.

[0130] IV. Statistical Analysis:

[0131] After treatment, the efficacy results showed that in the treatment group, 41 cases showed significant improvement and 24 cases showed improvement, with a total effective rate of 92.86%; in the control group, 31 cases showed significant improvement and 18 cases showed improvement, with a total effective rate of 72.06%. There was a significant difference in the treatment effects between the two groups, with the treatment group showing significantly better treatment effects than the control group (p<0.05), as detailed in Table 1.

[0132] Table 1: Comparison of treatment effects between the two groups of patients (n, %)

[0133] Group Example Effective Effective Ineffective Total effective rate Treatment group 70 41 24 5 92.86% Control group 68 31 18 19 72.06%

[0134] V. Typical Cases:

[0135] 1. Mr. Chen, male, 51 years old, office worker, with a family history of diabetes, fasting blood glucose 13.6 mmol / L, thin body, dry mouth, mental fatigue and weakness, frequent insomnia, and needs to take hypoglycemic drugs daily. After joining the treatment group in this trial, after 2 courses of treatment, his blood glucose was maintained at around 6.5 mmol / L, he no longer had insomnia, his weight was normal, and he was able to participate in normal daily work.

[0136] 2. Ms. Guo, 60 years old, had a fasting blood glucose of 14.2 and a postprandial blood glucose of 18.8. She regularly took metformin tablets. She joined the treatment group in this trial. After two courses of treatment, her preprandial blood glucose was 5.5 and her postprandial blood glucose was 7.3. Her blood glucose returned to normal and remained normal during a three-month follow-up.

[0137] 3. Mr. Zhao, male, 65 years old, retired, had diabetes for 5 years, with symptoms of dry throat and mouth, irritability, and excessive hunger. His fasting blood glucose was 15.1 and his postprandial blood glucose was 20.6. After joining the treatment group in this trial, his blood glucose was maintained at around 6.3 mmol / L after 2 courses of treatment, and his clinical symptoms were completely eliminated.

[0138] While performing the above-mentioned experiments on Example 1, the present invention also performed the same experiments on Examples 2-5, and obtained the same or similar results as Example 1, indicating that the present invention has good effects and stable and reliable therapeutic effects. These will not be listed one by one here.

[0139] VI. Adverse Reactions:

[0140] No adverse reactions were found in any of the observed cases, and there were no abnormal changes in blood, urine, stool routine tests, and electrocardiograms before and after medication, indicating that the clinical medication is safe.

[0141] VII. Conclusion:

[0142] In summary, this invention features a rationally formulated composition with scientific compatibility and synergistic effects. It is safe to use in the treatment of diabetes, with stable and reliable efficacy, and good results. It effectively reduces drug side effects, consolidates therapeutic effects, and alleviates the suffering of patients undergoing long-term medication, achieving a total effective rate of up to 92.86%. The preparation method is simple, easy to operate, and low-cost. Different technologies are employed to address the properties of the effective components of different medicinal materials, resulting in a significantly higher content of effective components compared to similar products. This fully utilizes the active ingredients, representing an innovation in diabetes medication with strong practical clinical application value and significant social and economic benefits.

[0143] It should be noted that the technical features and key aspects of this application are the compatibility of traditional Chinese medicine compositions. The capsules given above are only an example of one dosage form. Any technical solutions that are essentially the same as those in this application by using equivalent substitution methods, or various dosage forms suitable for oral administration prepared by conventional preparation methods using the traditional Chinese medicine compositions in this application, such as powders, granules, pills, decoctions, oral liquids, tablets, etc., are all within the scope of protection of this application.

Claims

1. A traditional Chinese medicine capsule for treating diabetes, characterized in that, It is made from the following raw materials by weight: 5-15 parts ginseng, 20-60 parts silkworm pupae, 25-75 parts stevia, 25-75 parts mesona chinensis, 10-30 parts amla, 25-75 parts reed rhizome, 20-60 parts green plum, 20-60 parts albizia bark, 10-30 parts loquat leaf, and 25-75 parts mallow fruit; (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 75-85℃, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, and sterilize them at 115-130℃ for 20-40 minutes to obtain the powder for later use. (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. For the first decoction, add water in an amount of 8 to 10 times the weight of the four raw materials and decoct for 1.5 to 2.5 hours. Filter to obtain the first filtrate. Add water in an amount of 6 to 8 times the weight of the four raw materials to the residue and decoct for 1 to 1.5 hours. Filter to obtain the second filtrate. Combine the two filtrates. Concentrate under reduced pressure to a thick paste with a relative density of 1.25 to 1.40 at 80 to 90 degrees Celsius to obtain a water-extracted thick paste. (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 6 to 8 times the weight of the four raw materials with 60 to 80% ethanol, heat to 70 to 80°C, reflux extract 2 to 3 times, 1 to 2 hours each time, combine the extracts, filter, recover the ethanol under reduced pressure, and concentrate to a thick paste with a relative density of 1.25 to 1.40 at 70 to 80°C to obtain the alcohol-extracted thick paste; (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2-3 hours, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder; (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer, dry at 60-80℃ for 2-3 hours to obtain dry granules; (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each containing 0.4g.

2. The traditional Chinese medicine capsule for treating diabetes according to claim 1, characterized in that, It is made from the following ingredients by weight: 5 parts ginseng, 20 parts silkworm pupae, 25 parts stevia, 25 parts gracilis, 10 parts amla, 25 parts reed rhizome, 20 parts green plum, 20 parts albizia bark, 10 parts loquat leaf and 25 parts mallow fruit. Among them, (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 75°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 120°C for 30 minutes, and obtain the powder for later use. (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. For the first decoction, add water equal to 8 times the weight of the four raw materials and decoct for 2.5 h. Filter to obtain the first filtrate. Add water equal to 8 times the weight of the four raw materials to the residue and decoct for 1 h. Filter to obtain the second filtrate. Combine the two filtrates. Concentrate under reduced pressure to a thick paste with a relative density of 1.25 at 80℃ to obtain a water-extracted thick paste. (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 6 times the weight of the four raw materials with 60% ethanol, heat to 70°C, reflux extract twice, 1.5 h each time, combine the extracts, filter, recover the ethanol under reduced pressure, and concentrate to a thick paste with a relative density of 1.25 at 70°C to obtain the alcohol-extracted thick paste. (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 3 hours, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder; (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 60°C for 3 hours to obtain dry granules; (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each containing 0.4g.

3. The traditional Chinese medicine capsule for treating diabetes according to claim 1, characterized in that, It is made from the following ingredients by weight: 10 parts ginseng, 40 parts silkworm pupae, 50 parts stevia, 50 parts gracilis, 20 parts amla, 50 parts reed rhizome, 40 parts green plum, 40 parts albizia bark, 20 parts loquat leaf and 50 parts mallow fruit. (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 85°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 115°C for 40 minutes, and obtain the powder for later use. (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. Add water to the first decoction with 9 times the weight of the four raw materials and decoct for 2 hours. Filter to obtain the first filtrate. Add water to the residue with 7 times the weight of the four raw materials and decoct for 1.5 hours. Filter to obtain the second filtrate. Combine the two filtrates. Concentrate under reduced pressure to a thick paste with a relative density of 1.30 at 85℃ to obtain a water-extracted thick paste. (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 7 times the weight of the four raw materials with 70% ethanol, heat to 80°C, reflux extract twice, 1.5 h each time, combine the extracts, filter, recover the ethanol under reduced pressure, and concentrate to a thick paste with a relative density of 1.30 at 80°C to obtain the alcohol-extracted thick paste. (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2.5 h, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder; (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 70°C for 3 hours to obtain dry granules. (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each containing 0.4g.

4. The traditional Chinese medicine capsule for treating diabetes according to claim 1, characterized in that, It is made from the following ingredients by weight: 15 parts ginseng, 60 parts silkworm pupae, 75 parts stevia, 75 parts gracilis, 30 parts amla, 75 parts reed rhizome, 60 parts green plum, 60 parts albizia bark, 30 parts loquat leaf, and 75 parts mallow fruit. Among them, (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 80°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 130°C for 20 minutes, and obtain the powder for later use. (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. For the first decoction, add water equal to 10 times the weight of the four raw materials and decoct for 1.5 h. Filter to obtain the first filtrate. Add water equal to 6 times the weight of the four raw materials to the residue and decoct for 1.5 h. Filter to obtain the second filtrate. Combine the two filtrates and concentrate under reduced pressure to a thick paste with a relative density of 1.40 at 90℃ to obtain a water-extracted thick paste. (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 8 times the weight of the four raw materials with 80% ethanol, heat to 80°C, reflux extract 3 times, 1 h each time, combine the extracts, filter, recover the ethanol under reduced pressure, concentrate to a thick paste with a relative density of 1.40 at 75°C, and obtain the alcohol-extracted thick paste. (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2 hours, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder; (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 80°C for 2 hours to obtain dry granules; (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each containing 0.4g.

5. The traditional Chinese medicine capsule for treating diabetes according to claim 1, characterized in that, It is made from the following ingredients by weight: 10 parts ginseng, 25 parts silkworm pupae, 50 parts stevia, 25 parts gracilis, 15 parts amla, 50 parts reed rhizome, 50 parts green plum, 30 parts albizia bark, 15 parts loquat leaf, and 30 parts mallow fruit. Among them, (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 80°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 118°C for 35 minutes, and obtain the powder for later use. (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. Add water to the first decoction twice. Add water to the first decoction twice. Add water to the residue twice. Add water to the residue twice. Decoction for 1 hour. Filter to obtain the second decoction. Combine the two decoctions. Concentrate under reduced pressure to a thick paste with a relative density of 1.35 at 80℃ to obtain a water-extracted thick paste. (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 8 times the weight of the four raw materials with 75% ethanol, heat to 75°C, reflux extract twice, 2 hours each time, combine the extracts, filter, recover the ethanol under reduced pressure, and concentrate to a thick paste with a relative density of 1.28 at 70°C to obtain the alcohol-extracted thick paste. (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2.5 h, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder; (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 65°C for 2.5 h to obtain dry granules; (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each containing 0.4g.

6. The traditional Chinese medicine capsule for treating diabetes according to claim 1, characterized in that, It is made from the following ingredients by weight: 12 parts ginseng, 30 parts silkworm pupae, 40 parts stevia, 50 parts gracilis, 20 parts amla, 40 parts reed rhizome, 40 parts green plum, 20 parts albizia bark, 20 parts loquat leaf, and 40 parts mallow fruit. (1) First, rinse the ginseng and silkworm pupae with water, dry them in an oven at 75°C, mix the ginseng and silkworm pupae, grind them in a pulverizer, pass them through a 120-mesh sieve, sterilize them at 125°C for 25 minutes, and obtain the powder for later use. (2) Add water to the four raw materials of stevia, mesona chinensis, amla, and reed rhizome and decoct twice. For the first decoction, add water equal to 10 times the weight of the four raw materials and decoct for 2.5 h. Filter to obtain the first filtrate. Add water equal to 7 times the weight of the four raw materials to the residue and decoct for 1.5 h. Filter to obtain the second filtrate. Combine the two filtrates and concentrate under reduced pressure to a thick paste with a relative density of 1.28 at 90℃ to obtain a water-extracted thick paste. (3) Mix the green fruit, albizia bark, loquat leaf and winter melon fruit, add 7 times the weight of the four raw materials with 75% ethanol, heat to 75°C, reflux extract 3 times, 1.5 h each time, combine the extracts, filter, recover the ethanol under reduced pressure, concentrate to a thick paste with a relative density of 1.35 at 80°C, and obtain the alcohol-extracted thick paste. (4) Mix the water-extracted thick paste and the alcohol-extracted thick paste evenly, vacuum dry for 2.5 h, pulverize, and pass through an 80-mesh sieve to obtain thick paste powder; (5) Mix the thick paste powder with ginseng and silkworm pupa powder evenly, granulate, place the granules in a boiling dryer and dry at 75°C for 2 hours to obtain dry granules; (6) Add 1% magnesium stearate by weight of dry granules, mix well, and fill into capsules, each containing 0.4g.