Composition with skin barrier repairing effect and preparation method thereof

Abstract

The present invention relates to a composition having a skin barrier repairing effect and a preparation method thereof, and belongs to the technical field of cosmetics. The composition comprises the following raw materials: Sargassum fusiformis polysaccharide, brown rice fermentation filtrate, acetyl heptapeptide-4, platycodon extract, Spirodendron extract, xylitol glucoside, dimethylsilanol hyaluronate and deionized water. Sargassum fusiformis polysaccharide, brown rice fermentation filtrate and acetyl heptapeptide-4 in the present invention complement each other and synergize to make the prepared composition have an excellent skin barrier repairing function; and brown rice fermentation filtrate platycodon extract and Spirodendron extract start from the dimensions of activating senescent cells, anti-oxidation and reducing collagen loss, and synergize to make the prepared composition have an excellent anti-aging effect; on this basis, the xylitol glucoside added by the present invention can also maintain the skin moisturizing state, and dimethylsilanol hyaluronate can quickly lock moisture, so that the prepared composition has an outstanding moisturizing effect.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular, relates to a composition having a skin barrier repairing function and a preparation method thereof. Background Art

[0002] The skin barrier is the protective layer of the skin and an important component of the skin. It is mainly composed of the sebum membrane and the stratum corneum. It plays a key role in resisting external stimuli, maintaining water balance, and resisting the invasion of foreign bodies. However, due to daily environmental pressure, ultraviolet radiation, bad living habits and other factors, the skin barrier is easily damaged, resulting in dry and sensitive skin and even wrinkles, spots and other signs of aging.

[0003] Therefore, in order to deal with such problems, more and more researchers have begun to conduct relevant research on compositions that repair the skin barrier. By deeply understanding the structure and function of the skin barrier and the mechanism of skin aging, researchers hope that the compositions they study can not only solve the single problem of repairing the skin barrier, but also find compositions that can replenish water and inhibit anti-aging in addition to repairing the skin barrier. Therefore, providing a three-in-one composition with the effects of repairing the skin barrier, replenishing water and anti-aging is of great significance to meet the current market demand, improve the actual performance of the product and meet consumer expectations. Summary of the invention

[0004] The purpose of the present invention is to provide a composition having the function of repairing the skin barrier and a preparation method thereof, so as to solve the problems existing in the prior art of composition technology of poor skin barrier repair effect and single function of the composition.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] A composition having a skin barrier repairing effect, comprising the following raw materials in parts by weight:

[0007]

[0008]

[0009] Brown rice is a whole-grain rice with complete vitality, which can improve cell viability and human immune function. The brown rice fermentation filtrate used in the present invention is purchased from Guangzhou Jiexin Chemical Co., Ltd., which is obtained by fermenting brown rice as the main substrate with selected yeast as the fermentation strain, and the nutrients in the brown rice are fully released, converted and enriched after fermentation. The brown rice fermentation filtrate contains a variety of active ingredients such as rich vitamin E, phytic acid, lactic acid, polyphenols, etc., which can improve cell viability, activate senescent cells, promote epidermal cell division, basal cell regeneration and tissue repair, help to inject vitality into skin cells, and promote skin barrier repair.

[0010] As a preferred technical solution of the present invention, the composition also includes deionized water.

[0011] As a preferred technical solution of the present invention, the deionized water is 55-70 parts by weight.

[0012] As a preferred technical solution of the present invention, the Platycodon grandiflorum extract is obtained by soaking and extracting the dried roots of the Platycodon grandiflorum plant of the Campanulaceae family at room temperature using 50% alcohol as an extraction solvent, with the ratio of the dried roots of Platycodon grandiflorum to alcohol being 1g:10mL by a conventional method.

[0013] As a preferred technical solution of the present invention, the Spirodendrum extract is obtained by soaking and extracting the dried whole herb of Spirodendrum, a floating plant on the water surface of the genus Spirodendrum of the Lemnaceae family, at room temperature using 30% alcohol as an extraction solvent, with the dried whole herb of Spirodendrum and alcohol used in a ratio of 1g:10mL using a conventional method.

[0014] A method for preparing a composition having a skin barrier repairing effect, the preparation method specifically comprising the following steps:

[0015] Mix the Sargassum fusiformis polysaccharide, Platycodon grandiflorum extract, Spirodendrum duckweed extract and deionized water evenly, then add acetyl heptapeptide-4, brown rice fermentation filtrate, xylitol glucoside and dimethylsilyl hyaluronate in sequence, control the temperature and stir evenly to obtain a finished composition with the function of repairing the skin barrier.

[0016] As a preferred technical solution of the present invention, the temperature for temperature-controlled uniform stirring is 26-30° C., and the stirring time is 10-15 min.

[0017] Application of a composition having a skin barrier repairing effect, wherein the composition having a skin barrier repairing effect is added into skin care products.

[0018] As a preferred technical solution of the present invention, the composition having the function of repairing the skin barrier accounts for 3-5% of the mass percentage of the skin care product.

[0019] As a preferred technical solution of the present invention, the skin care products include but are not limited to lotions, essences, facial masks, creams and toners.

[0020] Beneficial effects of the present invention:

[0021] (1) The present invention adds a water-soluble polysaccharide extracted from the brown algae Sargassum fusiformis polysaccharide to promote the expression of keratinized envelope component proteins to improve the barrier function of the stratum corneum; adds a brown rice fermentation filtrate containing a variety of active ingredients such as phytic acid, vitamin E, lactic acid, polyphenols, etc., which can improve cell vitality and activate senescent cells, while promoting epidermal cell division, basal cell regeneration and tissue repair, thereby helping to promote skin barrier repair; adds acetyl heptapeptide-4 to regulate the skin microbial community, strengthen the skin barrier function, and improve the integrity of the stratum corneum; that is, the three complement each other and synergistically enable the prepared composition to have an excellent skin barrier repair function.

[0022] (2) The present invention uses brown rice fermentation filtrate as the main functional substance to improve cell viability and activate senescent cells; on this basis, the Platycodon grandiflorum extract mainly contains triterpenoid saponins and also contains organic acids such as oleic acid, palmitic acid, and fatty acids to inhibit the degradation of mucopolysaccharides, eliminate free radicals and play an antioxidant role; the Spirodendrum duckweed extract containing flavonoids, Spirodendrum duckweed polysaccharides, vitamins and other ingredients inhibits collagenase activity and reduces collagen loss; the three ingredients work synergistically from the dimensions of activating senescent cells, anti-oxidation and reducing collagen loss to make the prepared composition have excellent anti-aging effects.

[0023] (3) The present invention adds xylitol glucoside to promote the synthesis of natural moisturizing factors of the skin and maintain the skin's hydration. On this basis, mild and highly permeable dimethylsilanol hyaluronate is added to form a protective film on the skin surface to quickly lock in moisture, promote the water circulation of the stratum corneum, and help the skin to deeply moisturize, so that the prepared composition has an outstanding moisturizing effect;

[0024] In addition, promoting skin moisture circulation through dimethylsilanol hyaluronate can also make the skin more plump and firm, further assisting brown rice fermentation filtrate, platycodon extract and dahlia extract to exert excellent anti-aging effects. DETAILED DESCRIPTION

[0025] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] The Sargassum fusiformis polysaccharide used in the embodiment of the present invention was purchased from Xi'an Senran Bioengineering Co., Ltd.; the brown rice fermentation filtrate used was purchased from Guangzhou Jiexin Chemical Co., Ltd., and was obtained by fermenting selected yeast as the fermentation strain and brown rice as the main substrate; the above will not be repeated in the following.

[0027] Example 1

[0028] A composition having a skin barrier repairing effect, comprising the following raw materials in parts by weight:

[0029]

[0030] The preparation method of the composition having the function of repairing skin barrier specifically comprises the following steps:

[0031] The above-mentioned weight portions of Sargassum fusiformis polysaccharide, Platycodon grandiflorum extract, Spirodendrum duckweed extract and deionized water are mixed evenly, and then acetyl heptapeptide-4, brown rice fermentation filtrate, xylitol glucoside and dimethylsilyl hyaluronate are added in sequence, and the temperature is controlled at 26° C. and stirred for 10 minutes until uniform, to obtain a finished composition with the function of repairing the skin barrier.

[0032] The finished composition with the function of repairing the skin barrier is added into the skin care product at 3% of the mass percentage of the skin care product, and the skin care product is the essence.

[0033] Example 2

[0034] A composition having a skin barrier repairing effect, comprising the following raw materials in parts by weight:

[0035]

[0036] The preparation method of the composition having the function of repairing skin barrier specifically comprises the following steps:

[0037] The above-mentioned weight portions of Sargassum fusiformis polysaccharide, Platycodon grandiflorum extract, Spirodendrum duckweed extract and deionized water are mixed evenly, and then acetyl heptapeptide-4, brown rice fermentation filtrate, xylitol glucoside and dimethylsilanol hyaluronate are added in sequence, and the temperature is controlled at 28° C. and stirred for 15 minutes until uniform, to obtain a finished composition with the function of repairing the skin barrier.

[0038] The finished composition with the function of repairing the skin barrier is added into the skin care product at 4% of the mass percentage of the skin care product, and the skin care product is toner.

[0039] Example 3

[0040] A composition having a skin barrier repairing effect, comprising the following raw materials in parts by weight:

[0041]

[0042]

[0043] The preparation method of the composition having the function of repairing skin barrier specifically comprises the following steps:

[0044] The above-mentioned weight portions of Sargassum fusiformis polysaccharide, Platycodon grandiflorum extract, Spirodendrum duckweed extract and deionized water are mixed evenly, and then acetyl heptapeptide-4, brown rice fermentation filtrate, xylitol glucoside and dimethylsilyl hyaluronate are added in sequence, and the temperature is controlled at 30°C and stirred for 13 minutes until uniform, to obtain a finished composition with the function of repairing the skin barrier.

[0045] The finished composition with the function of repairing the skin barrier is added into the skin care product at 5% of the mass percentage of the skin care product, and the skin care product is a face cream.

[0046] Comparative Examples 1-3

[0047] Compared with Example 1, the difference is that the weight parts of Sargassum fusiformis polysaccharide, brown rice fermentation filtrate and acetyl heptapeptide-4 in Comparative Examples 1-3 are as shown in Table 1, and the other parameters and operating steps remain unchanged.

[0048] Table 1

[0049]

[0050] Comparative Example 4

[0051] Compared with Example 1, the difference is that in Comparative Example 4, no brown rice fermentation filtrate is added, and the other parameters and operating steps remain unchanged.

[0052] Comparative Example 5

[0053] Compared with Example 1, the difference is that in Comparative Example 5, no Platycodon grandiflorum extract is added, and the other parameters and operating steps remain unchanged.

[0054] Comparative Example 6

[0055] Compared with Example 1, the difference is that in Comparative Example 6, no Spirodendrum extract is added, and other parameters and operating steps remain unchanged.

[0056] Comparative Example 7

[0057] Compared with Example 1, the difference is that in Comparative Example 7, xylitol glucoside is not added, and the other parameters and operating steps remain unchanged.

[0058] Comparative Example 8

[0059] Compared with Example 1, the difference is that in Comparative Example 8, dimethylsilanol hyaluronate is not added, and the other parameters and operating steps remain unchanged.

[0060] Test Example 1

[0061] Skin barrier repair test:

[0062] Transepidermal water loss (TEWL) is an important indicator for evaluating the function of the skin's moisture protection layer, and can accurately reflect the integrity of the skin's barrier function. The data in this test case were all measured under dry skin and no sweat, at an ambient temperature of 24°C and an ambient humidity of 50%. A positive TEWL value decrease rate indicates that the skin barrier has been repaired, otherwise, the skin barrier has not been repaired; and the greater the TEWL value decrease rate, the better the skin barrier repair effect.

[0063] The compositions with skin barrier repairing effect prepared in Examples 1-3 and Comparative Examples 1-3 were added to the essence matrix to prepare finished essence products (wherein, the amount of the composition with skin barrier repairing effect added to the essence was 3%) as samples, and 72 volunteers aged 24-50 with healthy skin and no history of skin diseases were selected and randomly divided into 6 groups, with 12 people in each group, and the samples made of the compositions with skin barrier repairing effect prepared in Examples 1-3, Comparative Examples 1-3 and Comparative Example 8 were tested respectively; the method of use was to evenly apply 0.6 g of the sample to the inner side of the forearm every morning and evening, and then the same tester used the same TEWL value tester to test the transepidermal water loss of the inner side of the forearm of the volunteers in the 0th week and after continuous use for the 2nd and 4th weeks, that is, how many grams of water were lost per square meter per hour.

[0064] Among them, TEWL value reduction rate (%) = (A0-A n ) / A0×100%;

[0065] Where A0 is the TEWL value of week 0, A n is the TEWL value of the nth week.

[0066] Average TEWL value decrease rate (%) = sum of TEWL value decrease rates of each group / total number of people in the group.

[0067] The test results are shown in Table 2.

[0068] Table 2

[0069] Average decrease rate of TEWL value in the second week (%) Average decrease rate of TEWL value in the 4th week (%) Example 1 9.4 17.5 Example 2 9.1 17.2 Example 3 9.2 17.3 Comparative Example 1 5.9 10.0 Comparative Example 2 5.0 8.8 Comparative Example 3 6.2 10.6

[0070] As can be seen from Table 2, the composition with the effect of repairing the skin barrier prepared by the present invention has an excellent skin barrier repairing function. In detail, it can be seen from Comparative Example 2 that the effect is most obvious when the brown rice fermentation filtrate is not added, because the brown rice fermentation filtrate is rich in phytic acid, vitamin E, lactic acid, polyphenols and other active ingredients, which can improve cell vitality, activate senescent cells, and promote epidermal cell division, basal cell regeneration and tissue repair, thereby helping to promote skin barrier repair; and it can be seen from Comparative Examples 1 and 3 that if the Sargassum polysaccharide or acetyl heptapeptide-4 is not added, the skin barrier repairing function of the composition is also relatively poor.

[0071] Test Example 2

[0072] Anti-aging test (DPPH free radical scavenging rate test):

[0073] (1) Preparation of DPPH solution: Take DPPH powder and prepare 0.1 mM DPPH solution with anhydrous ethanol. Store in a dark place.

[0074] (2) Preparation of sample solutions: The compositions having skin barrier repairing effect obtained in Examples 1-3, Comparative Examples 4-6 and Comparative Example 8 were respectively prepared into solutions with concentrations of 2.5 mg / mL, 5 mg / mL, 10 mg / mL, 20 mg / mL, 30 mg / mL, 40 mg / mL, 50 mg / mL and 60 mg / mL with anhydrous ethanol for later use.

[0075] (3) Determination steps:

[0076] Ai: 100 μL sample solution + 100 μL DPPH solution;

[0077] Aj: 100 μL sample solution + 100 μL anhydrous ethanol;

[0078] A0: 100 μL distilled water + 100 μL DPPH solution;

[0079] According to the above formula, Ai, Aj and A0 were mixed respectively, reacted at 37°C in the dark for 30 min, the absorbance at 517 nm was measured, and the test was repeated 3 times. The average value was taken and the DPPH clearance rate was calculated according to the following formula: DPPH clearance rate % = [1-(Ai-Aj) / A0] × 100%.

[0080] The test results are shown in Table 3.

[0081] Table 3

[0082] DPPH free radical scavenging rate (%) Example 1 82.63 Example 2 81.59 Example 3 82.04 Comparative Example 4 48.52 Comparative Example 5 64.70 Comparative Example 6 60.18 Comparative Example 8 71.35

[0083] As can be seen from Table 3, the composition with the function of repairing the skin barrier prepared by the present invention has an excellent anti-aging effect. This is because the present invention adds brown rice fermentation filtrate, platycodon extract and Spirodendrum extract, which activate senescent cells, resist oxidation and reduce collagen loss, so that the prepared composition has an excellent anti-aging effect; on this basis, the dimethylsilanol hyaluronate added by the present invention promotes skin water circulation, and can also make the skin fuller and firmer, further assisting the brown rice fermentation filtrate, platycodon extract and Spirodendrum extract to play an excellent anti-aging effect.

[0084] Test Example 3

[0085] 24 volunteers aged 28-50 with dry skin problems were selected, including 12 males and 12 females, and randomly divided into 2 groups, 12 in each group, and the compositions with skin barrier repairing effect prepared in Examples 1-3 and Comparative Examples 7-8 were added to the essence matrix to prepare the finished essence products (wherein, the amount of the composition with skin barrier repairing effect added to the essence was 3%) as samples;

[0086] The volunteers' faces were used as the test area to apply the finished essence product once a day in the morning and evening, with 1g of the sample evenly applied to the face area each time for 28 days. The skin moisture content was tested using the skin moisture tester CorneometerCM825 on the 0th day and 28th day after using the product to evaluate the skin moisture content before and after using the cream;

[0087] The results are shown in Table 4.

[0088] Table 4

[0089]

[0090] As can be seen from Table 4, the composition with the function of repairing the skin barrier prepared by the present invention has an outstanding moisturizing effect. Specifically, xylitol glucoside is used to promote the synthesis of natural moisturizing factors of the skin to maintain the moisturized state of the skin, and on this basis, mild and highly permeable dimethylsilanol hyaluronate is used to form a protective film on the skin surface to quickly lock in moisture, promote the water circulation of the stratum corneum, and help the deep moisturizing of the skin. Therefore, the prepared composition has an outstanding moisturizing effect.

[0091] In the description of the specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0092] The above contents are merely examples and explanations of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the invention or exceed the scope defined by the claims, they shall all fall within the protection scope of the present invention.

Claims

1. A composition having a skin barrier repairing effect, characterized in that: The composition comprises the following raw materials in parts by weight: The Platycodon grandiflorum extract is obtained by soaking the dried root of Platycodon grandiflorum, a plant of the Campanulaceae family, in 50% alcohol as an extraction solvent at room temperature using a conventional method; the Spirodendrum duckweed extract is obtained by soaking the dried whole herb of Spirodendrum duckweed, a floating plant of the genus Spirodendrum, a plant of the Lemnaceae family, in 30% alcohol as an extraction solvent at room temperature using a conventional method; The application of the composition with the function of repairing the skin barrier is to add the composition with the function of repairing the skin barrier into the skin care product at a weight percentage of 3-5% of the skin care product.

2. The composition having the effect of repairing the skin barrier according to claim 1, characterized in that: The composition also includes deionized water.

3. The composition having the effect of repairing the skin barrier according to claim 2, characterized in that: The deionized water is 55-70 parts by weight.

4. The composition having the effect of repairing the skin barrier according to claim 1, characterized in that: The skin care products include lotions, essences, facial masks, creams and toners.

5. A method for preparing a composition having a skin barrier repairing effect as claimed in any one of claims 2 to 4, characterized in that: The preparation method specifically comprises the following steps: Mix the Sargassum fusiformis polysaccharide, Platycodon grandiflorum extract, Spirodendrum duckweed extract and deionized water evenly, then add acetyl heptapeptide-4, brown rice fermentation filtrate, xylitol glucoside and dimethylsilyl hyaluronate in sequence, control the temperature and stir evenly to obtain a finished composition with the function of repairing the skin barrier.

6. The method for preparing the composition having the effect of repairing the skin barrier according to claim 5, characterized in that: The temperature for the temperature-controlled stirring is 26-30° C., and the stirring time is 10-15 min.

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