Automated liquid transfer device

Abstract

The present invention relates to the technical field of liquid transfer devices, and specifically to an automated liquid transfer tip device, comprising a mounting box, a mounting plate being arranged in the inner cavity of the mounting box, a plurality of suction nozzles being mounted on the mounting plate, and the lower end of each suction nozzle being suitable for plugging a suction nozzle; and also comprising a plurality of lifting and clamping mechanisms, the lifting and clamping mechanisms comprising a mounting seat, a lifting and driving mechanism, and a clamping assembly; the mounting seat is fixedly mounted on the output end of the lifting and driving mechanism, the clamping mechanism is fixedly mounted on the mounting seat, and the clamping mechanism is used to clamp or release the suction nozzle; the lifting and driving mechanism is used to drive the mounting seat and the clamping mechanism to move up and down, so as to realize the loading or disassembly of at least one group of suction nozzles and suction nozzles. In the present invention, the clamping mechanism always firmly clamps the suction nozzle during the loading process, which not only ensures the close connection between the suction nozzle and the suction nozzle, but also avoids the loosening or falling off that may occur during the loading or working process; in addition, the device can realize the loading or disassembly of a single group of suction nozzles and suction nozzles.

Description

Technical Field

[0001] The invention relates to the technical field of liquid transfer devices, in particular to an automatic liquid transfer head device. Background Art

[0002] Automated pipette tips are a type of equipment used for automated experimental operations, and are usually used for liquid handling and pipetting operations in laboratories. Their function is to achieve accurate absorption, delivery, and release of liquids to complete liquid handling tasks in experiments. Automated pipette tips are usually used in conjunction with automated pipettes or liquid handling systems to achieve the following functions: aspirating liquids, dispensing liquids, mixing liquids, diluting liquids, and sample processing.

[0003] In the related art, the Chinese patent publication number is CN115902276A, and its name is an automated pipetting device and its tip loading and unloading device, including a base, a tip loading assembly and a tip unloading assembly; the tip loading assembly includes a nozzle mounting plate and a plurality of nozzles; the top of the nozzle is connected to the suction and exhaust device through an air pipe, and the bottom of the nozzle is used for inserting the tip; the tip unloading assembly includes a tip unloading pressure plate, a guide block, a tube unloading push rod and a tip unloading tube respectively sleeved on the outside of each nozzle, which are arranged at the moving end of the vertical driving mechanism; when the nozzle is inserted into the nozzle, the nozzle can lift the tip unloading tube and then drive the tube unloading push rod to slide upward, and the nozzle unloading pressure plate can press the top of the tube unloading push rod and then drive the nozzle unloading tube to move downward to make the nozzle detachable. However, this device has the following problems: 1. The lower end of the nozzle body is generally formed with an insertion structure, which is used to insert the suction head. The insertion structure can specifically include a first conical structure and a second conical structure arranged in sequence from bottom to top. The first conical structure is used to align and position the suction head, and the second conical structure is used to fit tightly with the inner surface of the suction head, and the slope of the first conical structure is greater than the slope of the second conical structure. In this way, the suction head is guided and introduced through the first conical structure at the bottom, and then as the suction nozzle continues to be inserted into the suction head, the second conical structure will fit tightly with the inner surface of the suction head to achieve compact loading; because the plug-in method relies on the friction between the conical structure and the inner surface of the suction head to maintain the connection, there is a disadvantage of poor connection stability. Moreover, in a vibrating environment, such as when the equipment is working, the plug-in connection method is more easily affected, which will cause the connection between the nozzle and the suction head to gradually loosen. In addition, long-term plugging and pulling and friction may cause material fatigue, especially on the contact surface of the conical structure, which will reduce the stability and effectiveness of the connection. 2. The base is installed on the manipulator of the pipetting device. As the manipulator drives the tip loading and unloading device to the specified position of the tip, it moves downward to pierce the tip so that the bottom of the nozzle can hold the tip. This design can only realize the loading or disassembly of all nozzles and tips at the same time, and cannot realize the loading or disassembly of a single group of nozzles and tips, and has poor adaptability. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the purpose of the present invention is to provide an automated pipette tip device, which, by setting up multiple lifting and clamping mechanisms, can always firmly clamp the tip during the loading process, ensuring that it is stably and accurately inserted into the corresponding nozzle. This continuous clamping force not only ensures a tight connection between the tip and the nozzle, but also avoids loosening or falling off that may occur during loading or working; in addition, the device can realize the loading or disassembly of a single set of nozzles and tips, and can easily adapt to different experimental needs and pipetting tasks.

[0005] The purpose of the present invention is achieved by the following technical solutions:

[0006] A first aspect of the present invention provides an automated liquid transfer tip device, comprising a mounting box for connecting to a manipulator of a liquid transfer device, a mounting plate being arranged in the inner cavity of the mounting box, a plurality of suction nozzles being mounted on the mounting plate in a vertical direction, the lower end of each suction nozzle extending vertically downward out of the inner cavity of the mounting box, and the lower end of each suction nozzle being suitable for plugging a suction tip;

[0007] It also includes multiple lifting and clamping mechanisms, the number of which is the same as the number of the suction nozzles; the lifting and clamping mechanism includes a mounting seat, a lifting drive mechanism and a clamping assembly; the lifting drive mechanism is fixedly mounted on the mounting plate, the mounting seat is fixedly mounted on the output end of the lifting drive mechanism, the clamping mechanism is fixedly mounted on the mounting seat, and the clamping mechanism is used to clamp or release the suction head; the lifting drive mechanism is used to drive the mounting seat and the clamping mechanism to move up and down, so as to realize the loading or disassembly of at least one group of suction nozzles and suction heads.

[0008] In the first aspect of the present invention, as an optional embodiment, the lifting drive mechanism includes an electric telescopic rod; the housing of the electric telescopic rod is fixedly mounted on the mounting plate;

[0009] The mounting seat is formed by a top plate, a side plate and a bottom plate, and a receiving space is formed inside the mounting seat; the top plate is fixedly connected to the output shaft of the electric telescopic rod;

[0010] The clamping assembly includes two semicircular arc-shaped jaws and a clamping drive mechanism, wherein the clamping drive mechanism is installed in the accommodating space, and the clamping drive mechanism is used to drive the two semicircular arc-shaped jaws to move toward or away from each other to switch between a closed state and an open state; in the closed state, the two semicircular arc-shaped jaws are closed to each other to clamp the suction head; in the open state, the two semicircular arc-shaped jaws are separated from each other to release the suction head.

[0011] In the first aspect of the present invention, as an optional embodiment, the clamping drive mechanism includes a clamping drive motor, two first bevel gears and two second bevel gears;

[0012] The body of the clamping drive motor is fixedly mounted on the outer side wall of the side plate, the output shaft of the clamping drive motor extends into the accommodation space, and a helical gear ring is arranged on the outer surface of the output shaft of the clamping drive motor;

[0013] The two first bevel gears are rotatably mounted in the accommodation space and mesh with the bevel gear ring respectively;

[0014] The two second bevel gears are respectively fixedly mounted on the first ends of the two semicircular arc clamping jaws, and the two second bevel gears are meshed with the two second bevel gears in a one-to-one correspondence.

[0015] In the first aspect of the present invention, as an optional embodiment, the suction nozzle includes a connecting portion and a plug-in portion that are interconnected from top to bottom, the upper end of the connecting portion is used to communicate with the suction and exhaust device, an outer cover portion is provided outside the plug-in portion, and an annular gap is formed between the outer wall of the plug-in portion and the inner wall of the outer cover portion; a first convex ring is provided on the outer wall of the plug-in portion, and a first groove is provided on the inner wall of the outer cover portion;

[0016] The suction tip includes a suction tip tube body and a second convex ring arranged on the upper outer surface of the suction tip tube body; when the upper end of the suction tip tube body is inserted into the annular gap, the second convex ring can be clamped in the first groove to form a first sealing line, and the first convex ring is squeezed on the inner side of the first connecting tube to form a second sealing line.

[0017] In the first aspect of the present invention, as an optional embodiment, a protrusion is installed on the outside of the connecting part; a rectangular array of slots are opened on the mounting plate, and the protrusions are mounted in the slots. A limiting plate is installed on the mounting plate by screws, and the connecting part extends through and extends to the outside of the limiting plate, and the plug-in part and the outer cover part extend downward to the outside of the mounting plate.

[0018] In the first aspect of the present invention, as an optional embodiment, the suction head tube body includes a first connecting tube for plugging with the suction nozzle, the lower end of the first connecting tube is connected to the second connecting tube, the lower end of the second connecting tube is connected to the third connecting tube, and the second convex ring is arranged outside the first connecting tube.

[0019] In the first aspect of the present invention, as an optional embodiment, a filter element is placed in the first connecting pipe.

[0020] In the first aspect of the present invention, as an optional embodiment, a second groove is provided on the inner wall of the semicircular arc-shaped clamping jaw, and a third convex ring is also provided circumferentially on the outside of the first connecting tube; the semicircular arc-shaped clamping jaw is clamped on the outside of the third convex ring so that the third convex ring is engaged with the second groove.

[0021] In the first aspect of the present invention, as an optional embodiment, it further includes a positioning detection component, and the positioning detection component includes a pressure sensor and a moving part;

[0022] The pressure sensor is fixedly mounted on the outer surface of the connecting portion and is located above the outer cover portion;

[0023] The moving member comprises a moving ring, a plurality of ejector rods and an annular ejector block;

[0024] The movable ring is installed in the annular gap so as to be movable up and down. The annular top block is sleeved on the outer surface of the connecting portion and is located below the pressure sensor. The movable ring and the annular top block are fixedly connected via a plurality of top rods.

[0025] In the first aspect of the present invention, as an optional embodiment, the positioning detection assembly further includes a sealing ring, which is installed in the annular gap and is movably installed up and down and is located below the movable ring.

[0026] The present invention has the following beneficial effects:

[0027] 1. According to the automated pipetting tip device of the embodiment of the present invention, during the loading process, the clamping mechanism first clamps the tip to be loaded, the lifting drive mechanism starts, and the clamping mechanism and the tip are driven to move upward through the mounting seat. When the tip is fully inserted into the corresponding suction nozzle, the lifting drive mechanism stops moving. At this time, the clamping mechanism still maintains the clamping state of the tip to ensure that the tip is stably connected to the suction nozzle. During the disassembly process, the lifting drive mechanism starts again, and the clamping mechanism and the tip are driven to move downward through the mounting seat. When the tip is completely pulled out of the suction nozzle, the lifting drive mechanism stops moving, and the clamping mechanism releases the clamping of the tip to complete the disassembly process. In this way, during the loading process, the clamping mechanism always firmly clamps the tip to ensure that it is stably and accurately inserted into the corresponding suction nozzle. This continuous clamping force not only ensures the close connection between the tip and the suction nozzle, but also avoids the loosening or falling off that may occur during loading or working. In addition, the device can realize the loading or disassembly of a single set of suction nozzles and tips, and can easily adapt to different experimental needs and pipetting tasks. Whether it is necessary to replace a single tip or a whole set of tips, the device can complete it efficiently, greatly improving the flexibility and efficiency of the experiment.

[0028] 2. According to the automated liquid transfer tip device of the embodiment of the present invention, the present invention minimizes the space occupied by the entire lifting and clamping mechanism by tightly integrating the lifting drive mechanism and the clamping assembly on the mounting base. This compact design not only reduces the physical space required for the device, but also makes the connection between the components tighter, thereby improving the rigidity of the overall structure. By controlling the telescopic accuracy and the opening and closing accuracy of the clamping assembly, the stability and reliability of the lifting and clamping mechanism during operation are guaranteed.

[0029] 3. According to the automated liquid transfer tip device of the embodiment of the present invention, the present invention includes a positioning detection component, which includes a pressure sensor, a moving part, and a sealing ring; it can accurately detect the position of the tip and ensure a tight connection between it and the nozzle. This not only improves the reliability and accuracy of the device, but also greatly reduces the risk of leakage caused by loose connection.

[0030] 4. According to the automated liquid transfer tip device of an embodiment of the present invention, when the upper end of the tip tube body is inserted into the annular gap, the second convex ring will be stuck in the first groove to form a first sealing line. This is achieved by the close fit of the convex ring and the groove. At the same time, the first convex ring on the plug-in portion will be squeezed and pressed against the inner side of the tip or a connecting tube to form a second sealing line. This double sealing design ensures that gas will not leak from the connection during the suction and exhaust process, thereby improving the overall work efficiency and safety. In addition, after the tip stops moving, a close contact will be formed between its upper end and the sealing ring, which is the third sealing line. This sealing line further strengthens the sealing effect between the tip and the nozzle to ensure that no leakage occurs during the pipetting process. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The drawings in the specification, which constitute a part of this application, are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute improper limitations on the present invention.

[0032] Figure 1 It is a schematic diagram of the structure of the present invention;

[0033] Figure 2 It is a schematic diagram of the structure inside the installation box of the present invention;

[0034] Figure 3 It is a schematic diagram of the structure of the mounting plate and the protrusion of the present invention;

[0035] Figure 4 It is a structural schematic diagram of the mounting plate of the present invention;

[0036] Figure 5 It is a schematic diagram of the structure of the clamping assembly of the present invention when it is clamped;

[0037] Figure 6 It is a schematic diagram of the structure of the clamping assembly of the present invention after it is unfolded;

[0038] Figure 7 It is a schematic diagram of the internal structure of the suction head and the suction nozzle of the present invention;

[0039] Figure 8 It is a schematic diagram of the structure of the suction head of the present invention;

[0040] Fig. 9 It is a structural schematic diagram of the suction nozzle of the present invention;

[0041] Fig.10 It is a schematic diagram of the structure of the clamping assembly of the present invention;

[0042] Fig.11 For the present invention Figure 7 The structural diagram at A in the middle;

[0043] Fig.12 For the present invention Figure 7 Schematic diagram of the structure at B in the figure.

[0044] In the figure,

[0045] 10. Installation box; 11. Installation plate; 111. Card slot; 12. Limiting plate;

[0046] 20. Suction nozzle; 21. Connecting portion; 211. Protrusion; 22. Inserting portion; 221. First protruding ring; 23. Outer cover portion; 231. First groove; 24. Annular gap;

[0047] 30. suction head; 31. suction head body; 311. first connecting tube; 3111. third convex ring; 312. second connecting tube; 313. third connecting tube; 32. second convex ring;

[0048] 40. Lifting and clamping mechanism;

[0049] 41. mounting seat; 411. top plate; 412. side plate; 413. bottom plate; 414. accommodation space;

[0050] 42. Lifting drive mechanism;

[0051] 43. Clamping assembly; 431. Semicircular arc-shaped clamping claw; 4311. Second groove; 432. Clamping drive mechanism; 4321. Clamping drive motor; 4322. First helical gear; 4323. Second helical gear; 4324. Helical gear ring;

[0052] 50. Filter element;

[0053] 60. Positioning detection component; 61. Pressure sensor; 62. Moving part; 621. Moving ring; 622. Push rod; 623. Annular push block; 63. Sealing ring. DETAILED DESCRIPTION

[0054] Below, in conjunction with the accompanying drawings and specific embodiments, the present invention is further described. It should be noted that, under the premise of no conflict, the various embodiments described below or the various technical features can be arbitrarily combined to form a new embodiment. Except for special instructions, the materials and equipment used in this embodiment can be purchased from the market. Examples of embodiments are shown in the accompanying drawings, in which the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and the limitations of the present application cannot be understood.

[0055] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "back", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as a limitation on the present application. In the description of the present application, "plurality" means two or more, unless otherwise precisely and specifically specified.

[0056] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "connected", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, or it can be connected through an intermediary medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0057] The terms "first", "second", etc. in the specification and claims of this application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0058] See also Figure 1-Figure 12The embodiment of the present invention provides an automated liquid transfer head 30 device, including a mounting box 10 for connecting to a manipulator of a liquid transfer device, a mounting plate 11 is provided in the inner cavity of the mounting box 10, a plurality of suction nozzles 20 are vertically mounted on the mounting plate 11, the lower end of each suction nozzle 20 vertically extends downward from the inner cavity of the mounting box 10, and the lower end of each suction nozzle 20 is suitable for plugging a suction head 30;

[0059] It also includes multiple lifting and clamping mechanisms 40, the number of which is the same as the number of the suction nozzles 20; the lifting and clamping mechanism 40 includes a mounting seat 41, a lifting drive mechanism 42 and a clamping assembly 43; the lifting drive mechanism 42 is fixedly mounted on the mounting plate 11, the mounting seat 41 is fixedly mounted on the output end of the lifting drive mechanism 42, the clamping mechanism is fixedly mounted on the mounting seat 41, and the clamping mechanism is used to clamp or release the suction head 30; the lifting drive mechanism 42 is used to drive the mounting seat 41 and the clamping mechanism to move up and down, so as to realize the loading or disassembly of at least one group of suction nozzles 20 and suction heads 30.

[0060] On the basis of the above structure, according to the stamping die of the porous thin-walled part of the embodiment of the present invention, during the loading process, the clamping mechanism first clamps the suction head 30 to be loaded, and the lifting drive mechanism 42 is started, and the clamping mechanism and the suction head 30 are driven to move upward through the mounting seat 41. When the suction head 30 is fully inserted into the corresponding suction nozzle 20, the lifting drive mechanism 42 stops moving. At this time, the clamping mechanism still maintains the clamping state of the suction head 30, ensuring that the suction head 30 is stably connected to the suction nozzle 20. During the disassembly process, the lifting drive mechanism 42 is started again, and the clamping mechanism and the suction head 30 are driven to move downward through the mounting seat 41. When the suction head 30 is completely pulled out of the suction nozzle 20, the lifting drive mechanism 42 stops moving, and the clamping mechanism releases the clamping of the suction head 30, completing the disassembly process. In this way, during the loading process, the clamping mechanism always firmly clamps the suction head 30, ensuring that it is stably and accurately inserted into the corresponding suction nozzle 20. This continuous clamping force not only ensures a tight connection between the tip 30 and the nozzle 20, but also avoids loosening or falling off that may occur during loading or working. Due to the firm clamping of the clamping mechanism, the connection between the tip 30 and the nozzle 20 is very stable. This stability is essential to ensure the accuracy and repeatability of pipetting operations, especially in experimental environments that require high-precision pipetting. In addition, the device can realize the loading or disassembly of a single set of nozzles 20 and tips 30, and can easily adapt to different experimental needs and pipetting tasks. Whether it is necessary to replace a single tip 30 or replace an entire set of tips 30, the device can complete it efficiently, greatly improving the flexibility and efficiency of the experiment.

[0061] In a preferred embodiment of the present invention, the lifting drive mechanism 42 includes an electric telescopic rod; the housing of the electric telescopic rod is fixedly mounted on the mounting plate 11;

[0062] The mounting seat 41 is enclosed by a top plate 411, a side plate 412 and a bottom plate 413, and a receiving space 414 is formed inside the mounting seat 41; the top plate 411 is fixedly connected to the output shaft of the electric telescopic rod;

[0063] The clamping assembly 43 includes two semicircular arc-shaped jaws 431 and a clamping drive mechanism 432. The clamping drive mechanism 432 is installed in the accommodating space 414. The clamping drive mechanism 432 is used to drive the two semicircular arc-shaped jaws 431 to move toward or away from each other to switch between a closed state and an open state; in the closed state, the two semicircular arc-shaped jaws 431 are closed to each other to clamp the suction head 30; in the open state, the two semicircular arc-shaped jaws 431 are separated from each other to release the suction head 30.

[0064] On the basis of the above structure, the present invention minimizes the space occupied by the entire lifting and clamping mechanism 40 by tightly integrating the lifting drive mechanism 42 and the clamping assembly 43 on the mounting base 41. This compact design not only reduces the physical space required for the device, but also makes the connection between the components tighter, thereby improving the rigidity of the overall structure. By controlling the telescopic accuracy and the opening and closing accuracy of the clamping assembly 43, the stability and reliability of the lifting and clamping mechanism 40 during operation are guaranteed.

[0065] In a preferred embodiment of the present invention, the clamping drive mechanism 432 includes a clamping drive motor 4321, two first bevel gears 4322 and two second bevel gears 4323;

[0066] The body of the clamping drive motor 4321 is fixedly mounted on the outer wall of the side plate 412, the output shaft of the clamping drive motor 4321 extends into the accommodation space 414, and a helical gear ring 4324 is arranged on the outer surface of the output shaft of the clamping drive motor 4321;

[0067] The two first bevel gears 4322 are rotatably installed in the accommodation space 414 and mesh with the bevel gear ring 4324 respectively;

[0068] The two second bevel gears 4323 are respectively fixedly mounted on the first ends of the two semicircular arc clamping jaws 431 , and the two second bevel gears 4323 mesh with the two second bevel gears 4323 in a one-to-one correspondence.

[0069] On the basis of the above structure, when the clamping drive motor 4321 rotates forward or reversely, the two first bevel gears 4322 are driven to rotate through the bevel gear ring 4324. When the first bevel gear 4322 rotates, the corresponding second bevel gear 4323 (and the semicircular arc-shaped clamping claw 431 installed thereon) will be driven to rotate, and finally the two semicircular arc-shaped clamping claws 431 will be driven to move toward or away from each other, thereby achieving the action of clamping or releasing the suction head 30. In summary, this clamping drive mechanism 432 can stably and accurately control the opening and closing of the semicircular arc-shaped clamping claw 431 through the precise cooperation of the motor, the bevel gear ring 4324, the first bevel gear 4322 and the second bevel gear 4323, thereby achieving the function of clamping and releasing the suction head 30. This mechanism is exquisitely designed, has high transmission efficiency, and is relatively compact in structure.

[0070] In a preferred embodiment of the present invention, the nozzle 20 includes a connecting portion 21 and a plug-in portion 22 which are interconnected from top to bottom. The upper end of the connecting portion 21 is used to communicate with the suction and exhaust device. An outer cover portion 23 is provided outside the plug-in portion 22. An annular gap 24 is formed between the outer wall of the plug-in portion 22 and the inner wall of the outer cover portion 23. A first convex ring 221 is provided on the outer wall of the plug-in portion 22, and a first groove 231 is provided on the inner wall of the outer cover portion 23.

[0071] The suction head 30 includes a suction head 30 tube body and a second convex ring 32 arranged on the upper outer surface of the suction head 30 tube body; when the upper end of the suction head 30 tube body is inserted into the annular gap 24, the second convex ring 32 can be clamped in the first groove 231 to form a first sealing line, and the first convex ring 221 is squeezed on the inner side of the first connecting tube 311 to form a second sealing line.

[0072] On the basis of the above structure, a stable connection between the two can be ensured, and a good sealing effect can be formed; specifically, when the upper end of the pipette tube body 31 is inserted into the annular gap 24, the second convex ring 32 will be stuck in the first groove 231 to form a first sealing line. This is achieved by the close fit between the convex ring and the groove. At the same time, the first convex ring 221 on the plug-in part 22 will be squeezed and pressed against the inner side of the pipette 30 or a connecting tube to form a second sealing line. This double sealing design ensures that gas will not leak from the connection during the suction and exhaust process, thereby improving the overall work efficiency and safety.

[0073] In a preferred embodiment of the present invention, a protrusion 211 is installed on the outside of the connecting portion 21; a rectangular array of card slots 111 are opened on the mounting plate 11, and the protrusion 211 is clamped in the card slot 111. A limiting plate 12 is installed on the mounting plate 11 by screws, and the connecting portion 21 extends through and extends to the outside of the limiting plate 12, and the plug-in portion 22 and the outer cover portion 23 extend downward to the outside of the mounting plate 11.

[0074] On the basis of the above structure, the accurate positioning and firm fixation of the nozzle 20 on the mounting plate 11 can be ensured by the cooperation between the protrusion 211 and the slot 111 and the use of the limiting plate 12. This design not only improves the overall stability of the device, but also simplifies the installation and removal process.

[0075] In a preferred embodiment of the present invention, the suction head tube body 31 includes a first connecting tube 311 for plugging with the suction nozzle 20, the lower end of the first connecting tube 311 is connected to the second connecting tube 312, the lower end of the second connecting tube 312 is connected to the third connecting tube 313, and the second convex ring 32 is arranged outside the first connecting tube 311. The second convex ring 32 is arranged outside the first connecting tube 311 to ensure that the suction head 30 can be firmly connected to the suction nozzle 20.

[0076] In a preferred embodiment of the present invention, a filter element 50 is placed in the first connecting tube 311. The main function of the filter element 50 is to filter impurities or particles in the fluid to ensure the purity of the fluid. During the process of pipetting or aspirating, the filter element 50 can effectively prevent contaminants from entering the nozzle 20 or the subsequently connected device.

[0077] In a preferred embodiment of the present invention, a second groove 4311 is provided on the inner side wall of the semicircular arc clamping jaw 431, and a third convex ring 3111 is further provided on the outer side of the first connecting tube 311 along the circumferential direction; the semicircular arc clamping jaw 431 is clamped on the outer side of the third convex ring 3111, so that the third convex ring 3111 is engaged with the second groove 4311. In this way, a stable connection is achieved by engaging the third convex ring 3111 with the second groove 4311. This design can ensure a close fit between the two and improve the stability and reliability of the overall structure.

[0078] In a preferred embodiment of the present invention, a positioning detection component 60 is further included, and the positioning detection component 60 includes a pressure sensor 61, a moving part 62, and a sealing ring 63;

[0079] The pressure sensor 61 is fixedly mounted on the outer surface of the connecting portion 21 and is located above the outer cover portion 23;

[0080] The moving member 62 includes a moving ring 621, a plurality of ejector rods 622 and an annular ejector block 623;

[0081] The movable ring 621 is installed in the annular gap 24 so as to be movable up and down. The annular top block 623 is sleeved on the outer surface of the connecting portion 21 and is located below the pressure sensor 61. The movable ring 621 and the annular top block 623 are fixedly connected by a plurality of top rods 622.

[0082] The sealing ring 63 is installed in the annular gap 24 so as to be movable up and down and is located below the movable ring 621. Preferably, a limiting portion is provided in the annular gap 24 to limit the sealing ring 63 from escaping downward.

[0083] On the basis of the above structure, when the suction head 30 moves upward in the annular gap 24, its first connecting pipe 311 will push the sealing ring 63 to move upward. Since the sealing ring 63 is in close contact with the moving ring 621, the upward movement of the sealing ring 63 will push the entire moving member 62 (including the moving ring 621, the top rod 622 and the annular top block 623) to move upward. As the moving member 62 moves upward, the annular top block 623 will eventually squeeze the pressure sensor 61. When the pressure sensor 61 detects this squeezing force, it will send a signal to the central controller. After receiving this signal, the central controller will determine that the suction head 30 has been completely stuck in the suction nozzle 20, and control the lifting drive mechanism 42 to stop working accordingly, so that the suction head 30 stops moving. After the suction head 30 stops moving, a close contact will be formed between its upper end and the sealing ring 63, which is the third sealing line. This sealing line further strengthens the sealing effect between the suction head 30 and the suction nozzle 20 to ensure that no leakage occurs during the pipetting process. Through this design, the device can accurately detect the position of the suction head 30 and ensure a tight connection between it and the suction nozzle 20. This not only improves the reliability and accuracy of the device, but also greatly reduces the risk of leakage caused by loose connection.

[0084] The working principle of the present invention is as follows:

[0085] 1. Connection process:

[0086] Downward movement and positioning: The entire device moves downward under the control of the automated pipette until it reaches the predetermined position.

[0087] The semicircular arc clamping claw 431 moves: the electric telescopic rod operates to drive the semicircular arc clamping claw 431 to move downward to the outside of the third convex ring 3111 of the suction head 30.

[0088] Clamping and lifting: The semicircular arc clamping claw 431 clamps the third convex ring 3111 and moves upward through the electric telescopic rod to insert the suction head 30 into the suction nozzle 20.

[0089] 2. Sealing and testing:

[0090] The first connecting tube 311 squeezes the sealing ring 63 to move upward with the moving ring 621. The push rod 622 drives the push block to move upward until it squeezes the pressure sensor 61, confirming that the suction head 30 has been completely inserted into the suction nozzle 20.

[0091] Three sealing lines are formed to enhance the sealing effect:

[0092] First step: the second protruding ring 32 is inserted into the first groove 231 inside the outer cover 23 .

[0093] Second stage: the first convex ring 221 is in contact with the inner wall of the first connecting pipe 311 .

[0094] The third path: between the upper end of the first connecting pipe 311 and the sealing ring 63 .

[0095] Complete the connection: Detect the position of the suction tip 30 through the pressure sensor 61, confirm that the installation is complete, and perform subsequent pipetting operations.

[0096] 3. Disassembly process:

[0097] Downward movement and separation: After the pipetting operation is completed, the electric telescopic rod drives the semicircular arc-shaped clamping claw 431 to move downward, thereby driving the suction head 30 to move downward as a whole.

[0098] Release the seal and disengage: the first connecting tube 311 is separated from the first convex ring 221. The second convex ring 32 is separated from the first groove 231. The first connecting tube 311 gradually disengages from the annular gap 24 between the plug-in portion 22 and the outer cover portion 23.

[0099] Release and fall: the semicircular arc-shaped clamping claw 431 opens, releasing the connection with the third convex ring 3111, and the suction head 30 falls off and falls, completing the disassembly; the moving part 62 and the sealing ring 63 fall to the initial position under the action of gravity.

[0100] Although only certain components and embodiments of the present application have been illustrated and described, many modifications and changes may be conceived by those skilled in the art without actually departing from the scope and spirit of the claims, such as changes in the size, dimensions, structure, shape and proportion of the various elements, mounting arrangements, material usage, color, orientation, etc.

[0101] The above implementation modes are only preferred implementation modes of the embodiments of the present invention and cannot be used to limit the protection scope of the embodiments of the present invention. Any non-substantial changes and replacements made by technicians in this field on the basis of the embodiments of the present invention shall fall within the scope of protection required by the embodiments of the present invention.

Claims

1. An automated liquid transfer device, comprising a mounting box for connecting to a manipulator of a liquid transfer device, wherein a mounting plate is disposed in the inner cavity of the mounting box, and a plurality of suction nozzles are mounted on the mounting plate in a vertical direction, wherein the lower end of each suction nozzle extends vertically downward out of the inner cavity of the mounting box, and the lower end of each suction nozzle is suitable for plugging a suction head; characterized in that: It also includes a plurality of lifting and clamping mechanisms, the number of the lifting and clamping mechanisms being the same as the number of the suction nozzles; The lifting and clamping mechanism comprises a mounting seat, a lifting and driving mechanism and a clamping assembly; the lifting and driving mechanism is fixedly mounted on the mounting plate, the mounting seat is fixedly mounted on the output end of the lifting and driving mechanism, the clamping assembly is fixedly mounted on the mounting seat, and the clamping assembly is used to clamp or release the suction head; the lifting and driving mechanism is used to drive the mounting seat and the clamping mechanism to move up and down, so as to realize the loading or disassembly of at least one group of suction nozzles and suction heads; The suction nozzle comprises a connecting portion and a plug-in portion which are interconnected from top to bottom, the upper end of the connecting portion is used to communicate with the suction and exhaust device, an outer cover portion is arranged outside the plug-in portion, and an annular gap is formed between the outer wall of the plug-in portion and the inner wall of the outer cover portion; a first convex ring is arranged on the outer wall of the plug-in portion, and a first groove is arranged on the inner wall of the outer cover portion; The suction head comprises a suction head tube body and a second convex ring arranged on the outer surface of the upper part of the suction head tube body; the suction head tube body comprises a first connecting tube for plugging with the suction nozzle, when the upper end of the suction head tube body is plugged into the annular gap, the second convex ring can be clamped in the first groove to form a first sealing line, and the first convex ring is pressed on the inner side of the first connecting tube to form a second sealing line; It also includes a positioning detection component, which includes a pressure sensor, a moving part, and a sealing ring; the pressure sensor is fixedly installed on the outer surface of the connecting part and is located above the outer cover; the moving part includes a moving ring, a plurality of push rods and an annular top block; the moving ring is installed in the annular gap so as to be movable up and down, and the annular top block is sleeved on the outer surface of the connecting part and is located below the pressure sensor; the moving ring and the annular top block are fixedly connected by a plurality of push rods; The positioning detection component also includes a sealing ring, which is installed in the annular gap and is located below the moving ring so as to be movable up and down.

2. The automated liquid transfer tip device according to claim 1, characterized in that: The lifting drive mechanism comprises an electric telescopic rod; the housing of the electric telescopic rod is fixedly mounted on the mounting plate; The mounting seat is formed by a top plate, a side plate and a bottom plate, and a receiving space is formed inside the mounting seat; the top plate is fixedly connected to the output shaft of the electric telescopic rod; The clamping assembly comprises two semicircular arc-shaped clamping jaws and a clamping drive mechanism, wherein the clamping drive mechanism is installed in the accommodation space and is used to drive the two semicircular arc-shaped clamping jaws to move toward or away from each other to switch between a closed state and an open state; In the closed state, the two semicircular arc-shaped jaws close to each other to clamp the suction head; In the open position, the two semicircular arc-shaped clamping jaws move apart from each other to release the suction head.

3. The automated liquid transfer tip device according to claim 2, characterized in that: The clamping drive mechanism comprises a clamping drive motor, two first bevel gears and two second bevel gears; The body of the clamping drive motor is fixedly mounted on the outer side wall of the side plate, the output shaft of the clamping drive motor extends into the accommodation space, and a helical gear ring is arranged on the outer surface of the output shaft of the clamping drive motor; The two first bevel gears are rotatably mounted in the accommodation space and mesh with the bevel gear ring respectively; The two second bevel gears are respectively fixedly mounted on the first ends of the two semicircular arc clamping jaws, and the two second bevel gears are meshed with the two second bevel gears in a one-to-one correspondence.

4. The automated liquid transfer tip device according to claim 1, characterized in that: A protrusion is installed on the outside of the connecting part; a rectangular array of slots is opened on the mounting plate, and the protrusions are mounted in the slots. A limiting plate is installed on the mounting plate by screws, and the connecting part extends through to the outside of the limiting plate, and the plug-in part and the outer cover part extend downward to the outside of the mounting plate.

5. The automated liquid transfer tip device according to claim 1, characterized in that: The lower end of the first connecting pipe is connected to the second connecting pipe, the lower end of the second connecting pipe is connected to the third connecting pipe, and the second convex ring is arranged outside the first connecting pipe.

6. The automated liquid transfer tip device according to claim 2, characterized in that: A filter element is placed in the first connecting pipe.

7. The automated liquid transfer tip device according to claim 6, characterized in that: A second groove is arranged on the inner side wall of the semicircular arc-shaped clamping jaw, and a third convex ring is also arranged on the outside of the first connecting pipe along the circumferential direction; the semicircular arc-shaped clamping jaw is clamped on the outside of the third convex ring so that the third convex ring is engaged with the second groove.

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