A housing containing freeze-thaw bags and a freeze-thaw system

Abstract

The application discloses a shell containing a freeze-thaw bag, which has an inner surface and an outer surface, and the inner surface is formed with a cavity for simultaneously containing the freeze-thaw bag and a pipe body connected with the freeze-thaw bag; the cavity is divided into a freeze-thaw bag area for containing the freeze-thaw bag and a pipe body area for containing the pipe body, and a separation part is arranged between the freeze-thaw bag area and the pipe body area, and the cavity is provided with a channel for connecting the freeze-thaw bag area and the pipe body area near the separation part. The freeze-thaw bag and the pipe body are respectively placed in the freeze-thaw bag area and the pipe body area in the cavity, heat exchange and circulation between the two areas are promoted, and freezing and heating uniformity is improved, so that the effectiveness of biological material liquid in the freeze-thaw process is maintained.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of biological material liquid storage and transportation, and particularly relates to a shell containing a freeze-thaw bag and a freeze-thaw system. BACKGROUND

[0002] In the production process, in order to maintain the sterility of the biological material liquid such as antibodies and cells, the biological material liquid is usually stored in a disposable container. The disposable container is usually a biological material liquid bag made of flexible or soft material, and the outside of the biological material liquid bag is usually connected with a pipeline to realize the entry and exit of the biological material liquid into and out of the biological material liquid bag. However, the biological material liquid bag is prone to damage due to vibration, wear, impact or other improper handling accidents caused by the operator's mistake or improper protection during use. In particular, when the biological pharmaceutical material expands in volume during freezing, excessive pressure can be generated in the overfilled bag or in the closed liquid adjacent to the bag material, which can damage or destroy the integrity of the bag. In order to protect the integrity of the biological material liquid bag during freezing, the biological material liquid bag is currently placed in a shell for protection, so as to protect the integrity of the biological material liquid bag and the effectiveness of the biological material liquid inside. In the subsequent use process, the shell receiving the bag is placed in a special medical freezer or receiving rack and the like flat environment.

[0003] Therefore, in order to protect the integrity of the biological material liquid bag, the shell currently used on the market usually includes two completely separated chambers. One chamber is used to receive the biological material liquid bag, and the other chamber is used to receive the pipeline connected to the outside of the biological material liquid bag, so as to separate the biological material liquid bag and the pipeline to avoid damage to the integrity of the biological material liquid bag due to mutual interference.

[0004] However, since the complete separation between the two chambers is usually achieved by a continuous barrier, the heat exchange and circulation of the part of the biological material liquid bag and the pipeline contacting the continuous barrier are blocked, that is, the heat exchange between the chamber receiving the biological material liquid bag and the chamber receiving the pipeline is blocked, and the heat exchange between the two chambers is lost, resulting in insufficient heat exchange of the part of the biological material liquid bag and the pipeline contacting the continuous barrier, and further affecting the uniformity of freezing and heating of each part of the biological material liquid bag, the pipeline and the biological material liquid inside during the freeze-thaw process, and finally causing damage to the biological material liquid bag, the pipeline and the biological material liquid inside due to uneven freezing and heating. SUMMARY

[0005] In order to overcome the shortcomings of the prior art, the present application provides a shell containing a freeze-thaw bag, which places the freeze-thaw bag and the pipeline in a freeze-thaw bag area and a pipeline area in one chamber, respectively, to promote the heat exchange and circulation between the two areas, and the uniformity of freezing and heating, and further maintain the effectiveness of the biological material liquid during the freeze-thaw process.

[0006] The technical scheme adopted by the present application to solve its technical problems is: a shell containing a freeze-thaw bag, having an inner surface and an outer surface, the inner surface is formed with a cavity, the cavity is used to simultaneously accommodate the freeze-thaw bag and the pipe body connected with the freeze-thaw bag; the cavity is divided into a freeze-thaw bag area for accommodating the freeze-thaw bag and a pipe body area for accommodating the pipe body, and there is a partition between the freeze-thaw bag area and the pipe body area, and there is a passage in the cavity near the partition, which communicates the freeze-thaw bag area and the pipe body area.

[0007] Through the above technical scheme, in the present application, the shape of the shell is not limited, and the shape of the freeze-thaw bag is also not determined, the freeze-thaw bag in the empty state can be a flat bag (that is, the bag body of the freeze-thaw bag is basically attached without cavity between the bag body walls except for the cavities formed by the joints and welds and the like in the field of technology), or a three-dimensional bag (that is, there is at least one cavity between the bag body walls of the freeze-thaw bag in addition to the cavities formed by the joints and welds and the like in the field of technology); by using only one cavity to simultaneously accommodate the freeze-thaw bag and the pipe body, the exchange and circulation of heat between the freeze-thaw bag area and the pipe body area can be more sufficient and fast; at the same time, a partition is provided between the freeze-thaw bag area and the pipe body area to avoid mutual interference between the freeze-thaw bag and the pipe body, causing the freeze-thaw bag and the pipe body to be damaged, and there is a passage near the partition, which can be formed between the partition and the shell, or between multiple partitions, that is, the heat can be exchanged without obstruction between the freeze-thaw bag area and the pipe body area, so that the part of the freeze-thaw bag and the pipe body contacting the partition can be directly contacted with the heat at the passage, thereby increasing the contact area between the freeze-thaw bag, the pipe body and the heat, and further promoting the uniformity of freezing and heating of each part of the freeze-thaw bag, the pipe body and the biological liquid inside them, which is beneficial to the uniform freezing and heating of the freeze-thaw bag, the pipe body and the biological liquid inside them and maintaining the integrity.

[0008] Further, the number of partitions is multiple, adjacent partitions are independent of each other, and the passage is formed between adjacent partitions.

[0009] Through the above technical scheme, the partition does not connect to form a whole that separates the freeze-thaw bag area and the pipe body area, reducing the blocking area between the freeze-thaw bag area and the pipe body area, thereby ensuring the rapid and sufficient exchange and circulation of heat between the two areas, reducing the blocking area between the freeze-thaw bag area and the pipe body area, promoting the sufficient and fast exchange and circulation of heat between the freeze-thaw bag area and the pipe body area, and further promoting the uniformity of freezing and heating of each part of the freeze-thaw bag, the pipe body and the biological liquid inside them, which is beneficial to the uniform freezing and heating of the freeze-thaw bag, the pipe body and the biological liquid inside them and maintaining the integrity.

[0010] Further, the shell comprises a bottom portion defining the chamber and a rim portion surrounding the chamber, the rim portion comprises abutting segments and a gap segment, the abutting segments extend in a direction away from the bottom portion, and the gap segment is arranged corresponding to the tube body region so as to facilitate the tube body to enter and exit the chamber.

[0011] Through the above technical solution, the shell comprises the bottom portion and the rim portion, the overall setting structure is simple, the gap segment is formed between the adjacent abutting segments, the gap segment not only facilitates the taking and placing of the tube body and reduces the damage of the tube body, but also is beneficial to the exchange and circulation of heat between the inside and outside of the chamber.

[0012] Further, the gap segment is in communication with the channel.

[0013] Through the above technical solution, the channel and the gap segment connect the freeze-thaw bag region and the outside, not only promote the rapid exchange and sufficient circulation of heat between the freeze-thaw bag region and the tube body region, but also the heat exchange between the inside and outside of the chamber can be smoothly realized through the gap segment, so as to promote the rapid exchange and sufficient circulation of heat between the freeze-thaw bag region, the tube body region and the outside of the chamber.

[0014] Further, the shell is provided with a convection hole for communicating the inside and outside of the chamber, the convection hole is in communication with the channel; the periphery of the convection hole is recessed in a direction where the outer surface is located, and there is a flow space between the surface of the freeze-thaw bag and the convection hole as the freeze-thaw bag extends.

[0015] Through the above technical solution, the convection hole can realize the flow exchange of heat between the inside and outside of the chamber; since the convection hole is arranged in the freeze-thaw bag region of the chamber, and the channel and the convection hole are in communication, therefore, the heat in the freeze-thaw bag region and the outside of the chamber can realize rapid exchange and sufficient circulation, and the heat in the tube body region and the outside of the chamber can also realize rapid exchange and sufficient circulation, so as to realize the rapid exchange and sufficient circulation of heat among the outside of the chamber, the freeze-thaw bag region and the tube body region, and further promote the uniformity of freezing and heating of the freeze-thaw bag, the tube body and the biological liquid inside, and facilitate the uniform freezing and heating of the freeze-thaw bag, the tube body and the biological liquid inside to maintain the integrity.

[0016] Further, the inner surface of the shell forms a plurality of buffer portions which are protruded from the inner surface to the outer surface to form accommodation gaps for the partial extension of the freeze-thaw bag, and the buffer portions are alternately arranged with the convection hole.

[0017] By the technical scheme, on one hand, the structural firmness of the bottom of the shell is ensured, and the structural mechanical strength is prevented from being reduced due to the arrangement of the convection holes; and on the other hand, the buffer portions are arranged, so that even if the freeze-thaw bag tends to enter the buffer portions, the inserted part of the freeze-thaw bag cannot completely adhere to the surface of the buffer portion in the actual process, so that a flow space is formed between the freeze-thaw bag and the buffer portion, heat can be exchanged and circulated in the flow space, the freeze-thaw bag is uniformly heated, and the heat exchange and circulation in the cavity are promoted by the alternating arrangement of the buffer portions and the convection holes.

[0018] Further, the buffer portion is in the form of a groove, and a flow space is formed between the surface of the freeze-thaw bag and the bottom of the buffer portion as the freeze-thaw bag is inserted.

[0019] By the technical scheme, the buffer portion is in the form of an elongated groove, so that the freeze-thaw bag cannot completely adhere to the surface of the buffer portion, and the flow space is ensured.

[0020] Further, the inner surface of the shell is provided with a heat flow cavity, and the heat flow cavity is arranged correspondingly to the channel and / or the convection hole.

[0021] By the technical scheme, the heat flow cavity is protruded from the inner surface to the outer surface and has an opening facing the inner surface, heat can flow from the convection hole or the channel to the heat flow cavity, or heat in the heat flow cavity is exchanged and circulated to the convection hole and the channel, so that the heat exchange and circulation in the cavity are promoted.

[0022] Further, the outer surface of the shell is protruded to form a second partition portion facing away from the outer surface, and the second partition portion is higher than the edge portion.

[0023] By the technical scheme, when the outer surface of the shell is placed downward on a horizontal surface, the second partition portion is in contact with the horizontal surface, the edge portion is prevented from being in contact with the horizontal surface to block the heat, so that a gap is formed between the edge portion and the horizontal surface, and a gap is formed between the outer surface of the shell and the horizontal surface, heat can enter the outer surface of the shell through the gap between the edge portion and the horizontal surface and quickly contact the outer surface of the shell, so that the heat exchange and circulation in the cavity are quickly realized through the convection hole.

[0024] Further, a supporting portion is arranged at the connection between the freeze-thaw bag and the tube in the cavity, so that a flow space is formed between the tube and the bottom.

[0025] Through the technical scheme, the supporting part can form stable supporting effect on the connection part of the freeze-thaw bag and the pipe body, and meanwhile, the flow space is reserved between the pipe body and the bottom of the shell, so that heat can be quickly circulated and exchanged at the connection part of the pipe body and the shell.

[0026] Further, the shell is convex from the outer surface to the inner surface.

[0027] Through the technical scheme, in the freezing process, the freezing speed of the biological material liquid in the middle part of the freeze-thaw bag is slower than that of the biological material liquid in the peripheral part of the freeze-thaw bag, so that the biological material liquid in the middle part of the freeze-thaw bag has a curved shape (egg-shaped effect), thus causing uneven freezing progress of the freeze-thaw bag, and such unevenness is harmful to the freezing process of the protein of the biological material liquid. The bottom is convex towards the cavity, so that the shell restrains the middle part of the freeze-thaw bag, which can reduce the egg-shaped effect and is beneficial to the uniformity of the freezing progress.

[0028] Further, the partition part is convex from the inner surface of the shell, and a concave-convex limiting area is formed at the end away from the inner surface.

[0029] Through the technical scheme, the concave-convex limiting areas of the partition parts of the two shells are matched with each other to form a stable limiting structure, so as to avoid dislocation of the two shells in the splicing process caused by random movement of the two shells, thus causing blocking or overlapping of the structure between the two shells and further causing blocking of heat.

[0030] Further, the limiting elastic member is arranged in the pipe body area and abuts against the pipe body.

[0031] Through the technical scheme, the limiting elastic member limits the pipe body to avoid movement of the pipe body and falling out of the shell.

[0032] Further, the shell has a cuboid structure, and at least two partition parts are arranged on opposite sides of the shell.

[0033] Through the technical scheme, the needs of heat exchange and circulation of different types of pipe bodies are met.

[0034] The application further discloses a freeze-thaw system, which comprises a freeze-thaw bag, a pipe body connected with the freeze-thaw bag, and the shell.

[0035] Through the technical scheme, the freeze-thaw bag, the pipe body and the biological material liquid in the pipe body in the system are uniformly heated, which is beneficial to uniform heating and intactness of the freeze-thaw bag, the pipe body and the biological material liquid in the pipe body.

[0036] Further, the inner surfaces of the two shells are oppositely arranged to make the two cavities spliced to form a containing cavity, and the freeze-thaw bag and the pipe body are arranged in the containing cavity at the same time.

[0037] Through the above technical solution, the inner surfaces of the two shells are arranged opposite each other to form a receiving cavity. The freeze-thaw bag is placed in the receiving cavity and is fully and firmly clamped by the two shells, making the overall structure more stable and improving the integrity of the freeze-thaw bag, the tube and the biological liquid inside.

[0038] Furthermore, the freeze-thaw bag includes a bag body and a retaining portion connected to the bag body, the retaining portion being connected to an abutment section and / or a partition section to form a fixed fit between the bag body and the shell.

[0039] Through the above technical solution, the retaining part is connected to the bag body and simultaneously connected to the abutment section and / or partition section of the shell, thereby achieving a stable fixed fit between the shell and the bag body. The fixed fit can be any method well known to those skilled in the art, such as bolt connection, cable tie binding, or adhesive. The fixed fit helps to prevent the bag body from moving or being damaged by impact, thus providing effective protection for the bag body. Moreover, the fixed fit between the retaining part and the abutment section and / or partition section of the shell includes various situations. In some embodiments, the retaining part is fixedly fitted to only one abutment section and / or partition section of the shell; in other embodiments, the retaining part is clamped between two shells and fixedly fitted to the abutment section and / or partition section. With the above solution, since the abutting section is part of the edge and extends away from the bottom, and the partition is inside the cavity and can separate the bag body and the tube body, the abutting section and the partition protrude relative to the bottom of the shell. That is, there is a certain space between the holding part and the bottom of the shell, so that the tension force of the holding part on the bag body and the bottom of the shell are respectively separated. This helps to reduce the degree of expansion of the bag body, especially the middle part of the bag body, towards the bottom of the shell during the freezing expansion process. This is beneficial to the uniformity of the thickness of each part of the bag body after expansion, which is beneficial to the uniform freezing of the bag body.

[0040] Furthermore, the bag body includes a sidewall for containing liquid, the sidewall including at least two side edges, adjacent side edges extending to form an intersection, and the retaining portion connecting at least two oppositely disposed intersections.

[0041] By the technical scheme, the bag body can be a planar bag or a three-dimensional bag, and both the planar bag and the three-dimensional bag at least include two side edges, and adjacent side edges can be extended and formed with an intersection part, which can be a point, a line or a surface; the holding part is connected with at least two oppositely arranged intersection parts, that is, the two opposite intersection parts can provide balanced and stable tension to the bag body; and the holding part is connected with only the intersection part, or the holding part can be connected with the intersection part and a side wall and / or a side edge of the bag body extended from the intersection part, that is, the connection between the two includes the following schemes: a, only at the intersection part, b, simultaneously connecting the intersection part, the side wall and the side edge of the bag body, c, simultaneously connecting the intersection part and the side wall of the bag body, and d, simultaneously connecting the intersection part and the side edge of the bag body.

[0042] Further, at the intersection part, the holding part and the fixed fitting part of the abutting section and / or the separation part form a connection part.

[0043] By the technical scheme, since the fixed fitting of the holding part and the two oppositely arranged intersection parts can provide balanced and stable tension to the bag body, and the holding part and the abutting section and / or the separation part allow a certain distance between the bag body and the bottom of the shell to accommodate the expanded volume of the bag body, the above scheme can achieve balanced and stable tension to the bag body, and is beneficial to reduce the expansion degree of the bag body, especially the middle part of the bag body, towards the bottom of the shell during the freezing expansion process, and is beneficial to the thickness uniformity of each part of the bag body after expansion, thereby being beneficial to the uniform freezing of the bag body.

[0044] Further, the periphery of the connection part is provided with an intermittent part.

[0045] By the technical scheme, the periphery of the connection part is provided with an intermittent part, that is, the connection part has a notch, and when the volume of the biological liquid in the bag body expands after freezing, the bag body is more prone to deformation corresponding to the intermittent part, reducing the damage of the twisting and bending of the whole connection part to the biological liquid in the bag body, thereby being beneficial to the freezing expansion process of the bag body.

[0046] Further, the intermittent part includes two side edges, and the two side edges are extended and intersected to form an included angle θ, and the range of the included angle is 90°≤θ<180°.

[0047] By the technical scheme, the range of the included angle is 90°≤θ<180°, that is, the ends of the adjacent side edges away from the bag body extend in a direction away from each other, so that the tension of the connection part to the bag body presents multi-point force, achieving the uniformity of the tension of the connection part to the bag body while using a small amount of connection parts.

[0048] Further, the vertex of the included angle is arc-shaped; and / or, the vertex of the included angle and the side wall of the bag body form a connection zone, and the connection zone surrounds the side wall of the bag body.

[0049] Through the technical scheme, as the bag body expands, the vertex of the included angle is arc-shaped, which is conducive to reducing the tearing of the connecting portion at the corresponding intermittent portion along with the opening of the included angle, and further reducing the tearing along the bag body to cause damage to the bag body; the vertex of the included angle and the side wall of the bag body form a connecting area, and the connecting area surrounds the side wall of the bag body, thereby increasing the connecting area between the connecting portion and the bag body, and thereby avoiding the breakage or damage of the connecting portion and the side wall of the bag body.

[0050] Further, the bag body has a cavity in an empty state.

[0051] Through the technical scheme, in the freezing process, as the bag body expands, the biological material liquid is driven to concentrate in the middle of the bag body under the action of gravity, so that the middle of the bag body expands more than the periphery of the bag body, thereby driving the shell corresponding to the middle of the bag body to expand towards the outer surface, thereby increasing the hollow space of the shell corresponding to the middle of the bag body, and further promoting the biological material liquid to flow to the middle of the bag body under the action of gravity, thereby increasing the amount of biological material liquid carried by the shell corresponding to the middle of the bag body, causing the middle of the bag body to further expand towards the outer surface under the action of pressure, further promoting the biological material liquid to continue to flow to the middle of the bag body, thereby causing the middle of the bag body to expand more than the periphery of the bag body, resulting in uneven freezing, and at the same time, there are bends and wrinkles at the transition between the middle of the bag body and the periphery of the bag body, causing damage to the biological material liquid, and the transition expansion of the bag body reduces the strength of the bag body and causes damage. At the same time, during the expansion of the bag body, the periphery of the bag body will shrink inward, resulting in low direct space utilization of the shell corresponding to the shrinkage of the bag body, and the shrinkage will also cause the skirt to be stretched. However, if the size of the bag body is enlarged, the excess size will form many wrinkles and bends when the bag body is assembled into the cavity of the shell, thereby damaging the biological material liquid inside the bag body during the freezing process. Therefore, the bag body has a cavity in an empty state, i.e. when the bag body is not filled with any material, at this time the bag body is a three-dimensional bag, which includes two structures: the bag body can be a 3D bag with a cavity inside; or the bag body side wall can form wrinkles, i.e. even when the bag body side wall is fitted, there will be multiple cavities at the wrinkles due to irregular folding (this structure can be formed by pre-stretching and setting along the thickness direction of the side wall, which will not be described here) ; the above bag body structure increases the filling amount of the bag body in the cavity of the shell, and is conducive to balancing the filling amount of the bag body and the uniformity of the freezing process and the strength of the bag body.

[0052] Further, the edge portion of the shell forms a first shape portion and a second shape portion arranged at intervals, and the first shape portion and the second shape portion are complementary to form a limiting fit when the outer surfaces of the two shells are arranged opposite to each other.

[0053] Through the technical scheme, the first shape part can be inserted into the second shape part, a limiting fit is formed between the two oppositely arranged housings, and misalignment of the two housings during splicing caused by random movement of the housings is avoided, so that problems such as blocking or overlapping of structures between the two housings are caused, and heat is blocked.

[0054] The beneficial effects of the present application are:

[0055] 1、Through the technical scheme, the shape of the housing is not limited, and only one cavity is used to simultaneously accommodate the freeze-thaw bag and the pipe body, so that the exchange and circulation of heat between the freeze-thaw bag area and the pipe body area are more sufficient and rapid; meanwhile, a separation part is arranged between the freeze-thaw bag area and the pipe body area to avoid mutual interference between the freeze-thaw bag and the pipe body to cause damage to both, and a passage is further arranged near the separation part, which is formed between the separation part and the housing or between multiple separation parts, so that heat can be exchanged without obstruction between the freeze-thaw bag area and the pipe body area, so that the part of the freeze-thaw bag and the pipe body contacting the separation part can be directly contacted with heat at the passage, thereby increasing the contact area between the freeze-thaw bag, the pipe body and heat, and promoting the uniformity of freezing and heating of the freeze-thaw bag, the pipe body and the biological liquid inside, which is beneficial to the uniform freezing and heating of the freeze-thaw bag, the pipe body and the biological liquid inside to maintain the integrity;

[0056] 2、The gap segment is communicated with the passage, and the passage and the gap segment communicate the freeze-thaw bag area and the outside, which not only promotes the rapid exchange and sufficient circulation of heat between the freeze-thaw bag area and the pipe body area, but also enables the heat exchange between the inside and outside of the cavity to be smoothly realized through the gap segment, so that the heat of the freeze-thaw bag area, the pipe body area and the outside of the cavity is rapidly exchanged and sufficiently circulated;

[0057] 3. By setting the buffer part, on the one hand, guarantee the structure firmness of the bottom of the shell, avoid because set the convection hole causes its structure mechanical strength to decline, at the same time, because the buffer part is multiple, equivalent to multiple buffer parts divide the shell from the whole into multiple parts, to a certain extent, also conducive to the deformation of the shell and suitable for the volume expansion of the freeze-thaw bag in the freezing process; on the other hand, compared with the smooth bottom, after setting the buffer part, even if the freeze-thaw bag tends to enter the buffer part, but the actual process of the freeze-thaw bag cannot completely fit in the surface of the buffer part, so that there will be a flow space between the two, heat can exchange and circulate in the flow space, so that the freeze-thaw bag is evenly heated, because of the alternate arrangement of the buffer part and the convection hole, it promotes the heat exchange and circulation inside and outside the chamber, and also exchanges and circulates in the flow space, further promotes the sufficiency of heat exchange and circulation; on the other hand, compared with the smooth bottom, after setting the buffer part, even if the freeze-thaw bag tends to enter the buffer part, but the actual process of the freeze-thaw bag cannot completely fit in the surface of the buffer part, so that there will be a flow space between the two, heat can exchange and circulate in the flow space, so that the freeze-thaw bag is frozen and heated. BRIEF DESCRIPTION OF DRAWINGS

[0058] Figure 1 The three-dimensional structure diagram of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown. Figure 1 At this time, the inner surface is shown.

[0059] Figure 2 The three-dimensional structure diagram of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown. Figure 1 The enlarged view of the structure at A in the above figure.

[0060] Figure 3 The three-dimensional structure diagram of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown. Figure 2 At this time, the outer surface is shown.

[0061] Figure 4 The three-dimensional structure diagram of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown.

[0062] Figure 5 The three-dimensional structure diagram of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown.

[0063] Figure 6 The side view of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown.

[0064] Figure 7 The cross-sectional view of the shell for accommodating the freeze-thaw bag provided by the embodiment one of the present application is shown.

[0065] Figure 8 The three-dimensional structure diagram of the freeze-thaw system provided by the embodiment two of the present application is shown.

[0066] Figure 9 Side view of the freeze-thaw system according to Embodiment 2 of the present application.

[0067] Figure 10 Sectional view of the freeze-thaw system according to Embodiment 2 of the present application, at this time, the freeze-thaw bag and the tube are not shown.

[0068] Figure 11 Perspective structural schematic view of the freeze-thaw bag according to Embodiment 2 of the present application.

[0069] Figure 12 Side view of the freeze-thaw system according to Embodiment 3 of the present application, at this time, a plurality of housings are stacked up and down.

[0070] Figure 13 Perspective view of the freeze-thaw system according to Embodiment 3 of the present application, at this time, a plurality of housings are stacked up and down.

[0071] Figure 14 Perspective structural schematic view of the housing containing the freeze-thaw bag according to Embodiment 5 of the present application Figure 1 , at this time, the inner surface is shown.

[0072] Figure 15 Perspective structural schematic view of the housing containing the freeze-thaw bag according to Embodiment 5 of the present application Figure 2 , at this time, the outer surface is shown.

[0073] Figure 16 Perspective structural schematic view of the housing containing the freeze-thaw bag, the freeze-thaw bag and the tube according to Embodiment 5 of the present application.

[0074] Figure 17 Perspective structural schematic view of the freeze-thaw system according to Embodiment 5 of the present application.

[0075] Figure 18 Side view of the freeze-thaw system according to Embodiment 5 of the present application.

[0076] Figure 19 Side view of the freeze-thaw system according to Embodiment 5 of the present application, at this time, a plurality of housings are stacked up and down.

[0077] Figure 20 Perspective view of the freeze-thaw system according to Embodiment 5 of the present application, at this time, a plurality of housings are stacked up and down.

[0078] Figure 21 Top view of the housing containing the freeze-thaw bag, the freeze-thaw bag and the tube according to Embodiment 6 of the present application.

[0079] Figure 22 Top view of the housing containing the freeze-thaw bag, the freeze-thaw bag and the tube according to Embodiment 7 of the present application.

[0080] Figure 23 A schematic view of the overall structure of the freeze-thaw bag provided for Embodiment Eight of the present application.

[0081] Figure 24 A top view of the cooperation between the shell and the holding part of the freeze-thaw bag provided for Embodiment Eight of the present application.

[0082] Figure 25 A top view of the cooperation between the shell and the holding part of the freeze-thaw bag provided for Embodiment Nine of the present application.

[0083] Figure 26 A schematic view of the overall structure of the freeze-thaw bag provided for Embodiment Ten of the present application.

[0084] Figure 27 A schematic view of the cavity inside the freeze-thaw bag provided for Embodiment Ten of the present application.

[0085] Wherein, 11 - inner surface, 12 - outer surface, 121 - second partition part, 13 - bottom, 14 - edge part, 141 - abutting section, 142 - notch section, 15 - convection hole, 151 - convection hole periphery, 16 - buffer part, 161 - buffer part bottom flow-through space, 17 - heat flow-through cavity, 18 - supporting part, 191 - first shape part, 192 - second shape part, 2 - chamber, 20 - containing cavity, 21 - freeze-thaw bag area, 22 - tube body area, 3 - freeze-thaw bag, 31 - holding part, 32 - bag body, 321 - side wall, 322 - side edge, 323 - interface part, 4 - tube body, 41 - tube body liquid outlet end, 5 - partition part, 51 - concave-convex limiting area, 6 - channel, 7 - connecting part, 71 - discontinuous part, 72 - side edge, 73 - included angle, 74 - connecting area, 8 - cavity. DETAILED DESCRIPTION

[0086] In order to enable persons skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the accompanying drawings of the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by persons skilled in the art without creative labor should fall within the protection scope of the present application.

[0087] Embodiment One

[0088] As Figures 1-7As shown, a housing for accommodating a freeze-thaw bag has an inner surface 11 and an outer surface 12. The inner surface 11 forms a chamber 2 for simultaneously accommodating a freeze-thaw bag 3 and a tube 4 connected to the freeze-thaw bag 3. The chamber 2 is divided into a freeze-thaw bag region 21 for accommodating the freeze-thaw bag 3 and a tube region 22 for accommodating the tube 4. A partition 5 is provided between the freeze-thaw bag region 21 and the tube region 22. A channel 6 communicating between the freeze-thaw bag region 21 and the tube region 22 is located within the chamber 2 near the partition 5.

[0089] by Figure 1 Taking the direction shown as an example, the inner surface 11 refers to the side shown, and the outer surface 12 refers to the side that is covered. The inner surface 11 forms a chamber 2, which can be an open chamber 1 as shown in the figure. The freeze-thaw bag 3 and the tube 4 are placed in one chamber 2. It is emphasized here that there is only one chamber 2. The freeze-thaw bag area 21 and the tube area 22 are not areas formed by the separation of specific components, but are artificially defined as the area where the freeze-thaw bag 3 is placed and the area where the tube 4 is placed is the tube area 22. Furthermore, the function of the partition 5 between the freeze-thaw bag area 21 and the tube area 22 is not to completely isolate the freeze-thaw bag area 21 and the tube area 22, but to prevent the freeze-thaw bag 3 from pressing on the tube 4 during the deformation process, which would lead to damage to the tube 4 and uneven freezing and heating of the tube 4.

[0090] The number of tubes 4 can be one, two, or three or more. When there are two tubes 4, they are located on both sides of the freeze-thaw bag 3. At this time, there are also at least two partitions 5, and at least two partitions 5 are located on opposite sides of the shell. In other words, at least two partitions 5 are located on both sides of the freeze-thaw bag 3, so that the freeze-thaw bag 3 and the tubes 4 can be separated from each other, avoiding the freeze-thaw bag 3 pressing on the tubes 4.

[0091] In this embodiment, there are two tubes 4 and multiple partitions 5. Adjacent partitions 5 are independent of each other, and the aforementioned channel 6 is formed between adjacent partitions 5. The partitions 5 are independent, meaning they do not connect to form a single unit separating the freeze-thaw bag area 21 and the tube area 22. This reduces the obstruction area between the freeze-thaw bag area 21 and the tube area 22, ensuring rapid and sufficient heat exchange and circulation between the two areas. Reducing the obstruction area between the freeze-thaw bag area 21 and the tube area 22 promotes more thorough and rapid heat exchange and circulation, thereby promoting uniform freezing and heating of the freeze-thaw bag 3, the tube 4, and the biological liquid inside them. This helps maintain the integrity of the freeze-thaw bag 3, the tube 4, and the biological liquid inside them.

[0092] The shape of the shell in this invention is not limited. By using only one chamber 2 to simultaneously accommodate the freeze-thaw bag 3 and the tube 4, the exchange and circulation of heat between the freeze-thaw bag area 21 and the tube area 22 can be more thorough and rapid. At the same time, a partition 5 is provided between the freeze-thaw bag area 21 and the tube area 22 to avoid mutual interference between the freeze-thaw bag 3 and the tube 4, which could cause them to break. There is also a channel 6 near the partition 5. The channel 6 can be formed between the partition 5 and the shell, or between multiple partitions 5. That is, heat can flow freely between the freeze-thaw bag area 21 and the tube area 22. This allows the parts of the freeze-thaw bag 3 and the tube 4 that are in contact with the partition 5 to be in direct contact with heat at the channel 6, thereby increasing the contact area between the freeze-thaw bag 3 and the tube 4 and the heat. This promotes the uniformity of heating of the freeze-thaw bag 3, the tube 4 and the biological liquid inside them, which is beneficial for the freeze-thaw bag 3, the tube 4 and the biological liquid inside them to remain intact during freezing and heating.

[0093] In this embodiment, the tube 4 extends from the connection point with the freeze-thaw bag 3 to both sides of the freeze-thaw bag 3. For example... Figure 4 As shown, in this embodiment, the shell is roughly rectangular, and the freeze-thaw bag 3 is also rectangular. Both the shell and the freeze-thaw bag 3 have their shorter side as the width direction and their longer side as the length direction. The two tubes 4 are connected in the width direction of the freeze-thaw bag 3, and the tubes 4 are bent and extend along the length direction of the freeze-thaw bag 3. Of course, in other embodiments, the shell can also be any shape, such as circular, and there is no specific limitation.

[0094] More specifically, in this embodiment, there are six partitions 5, which are located on both sides of the freeze-thaw bag 3. A channel 6 is provided between adjacent partitions 5 along the length of the shell, and adjacent partitions 5 are directly opposite each other along the width of the shell. Each partition 5 protrudes from the inner surface 11 of the shell, and a recessed-protrusion limiting area 51 is formed at the end of the partition 5 away from the inner surface 11. Here, the recessed-protrusion limiting area 51 refers to the fact that the end face of the partition 5 away from the inner surface 11 is not horizontal and is uneven. More specifically, the shapes of the recessed-protrusion limiting areas 51 of adjacent partitions 5 are different. If the protruding area of ​​the concave-convex limiting area 51 of one of the partitions 5 extends along the width direction of the shell, then the protruding area of ​​the concave-convex limiting area 51 of the adjacent partition 5 can extend along the length direction of the shell. Thus, when the shell is stacked with another shell, or when the shell is stacked with another object, the aforementioned concave-convex limiting area 51 can limit the width direction and the length direction of the shell, avoiding misalignment of the two shells during the splicing process caused by the shell moving randomly during use, which would lead to problems such as obstruction or overlap of the structure between the two shells, and thus blockage of heat.

[0095] The shell includes a bottom 13 defining a chamber 2 and an edge portion 14 surrounding the chamber 2. The edge portion 14 includes an abutment section 141 and a notch section 142. The abutment section 141 extends away from the bottom 13, and the notch section 142 is provided corresponding to the tube body region 22, thereby facilitating the entry and exit of the tube body 4 inside and outside the chamber 2. Specifically, the notch section 142 being provided corresponding to the tube body region 22 refers to, for example... Figure 4 As shown, the area where the tube body 4 extends along the length of the freeze-thaw bag 3 is a notch section 142, so the liquid outlet end 41 of the tube body 4 and the part of the tube body 4 near the liquid outlet end 41 can freely extend or retract into the tube body area 22 from the notch section 142. Therefore, the tube body 4 is very convenient to take out and use, and it also reduces the damage to the tube body 4. Moreover, it is conducive to the exchange and circulation of heat between the inside and outside of the chamber 2.

[0096] At the same time, the gap section 142 is connected to the channel 6, so the channel 6 and the gap section 142 connect the freeze-thaw bag area 21 with the outside world. This not only promotes the rapid exchange and full circulation of heat between the freeze-thaw bag area 21 and the tube body area 22, but also enables the heat exchange inside and outside the chamber 2 to be smoothly realized through the gap section 142, thus promoting the rapid exchange and full circulation of heat between the freeze-thaw bag area 21, the tube body area 22, and the outside of the chamber 2.

[0097] Of course, in addition to the continuously extending portion, the notch section 142 also includes a portion located in the width direction of the shell, which can facilitate heat exchange between the interior and exterior of each area of ​​the chamber 2. In other words, the location of the notch section 142 is not limited.

[0098] To prevent the outlet end 41 of the tube 4 from bending and causing damage to the tube 4, the outlet end 41 of the tube 4 does not extend beyond the rightmost end (within...). Figure 4 (Taking the direction shown as an example) the separation part 5, or the length of the liquid outlet end 41 of the tube body 4 extending beyond the rightmost separation part 5 is less than or equal to the thickness of the separation part 5. Here, the thickness of the separation part 5 refers to the width direction of the freeze-thaw bag 3, so that the liquid outlet end 41 of the tube body 4 will not abut against the rightmost separation part 5 and bend, ensuring the normal use of the tube body 4.

[0099] To prevent the tube 4 from moving freely within the tube area 22, a limiting elastic element is provided within the tube area 22. This limiting elastic element abuts against the tube 4, thereby limiting the tube 4 and preventing it from moving, breaking, or falling outside the shell.

[0100] In order to further realize the circulation and exchange of heat inside and outside the chamber 2, a convection hole 15 for communicating the inside and outside of the chamber 2 is arranged on the shell, and the convection hole 15 is communicated with the channel 6. Here, the communication between the convection hole 15 and the channel 6 means that the convection hole 15 is arranged just opposite to the channel 6, for example, two or more convection holes 15 are distributed along the width direction of the freeze-thaw bag 3, and then the above-mentioned convection hole 15 is just located on the line connecting the freeze-thaw bag 3 on both sides opposite to the channel 6. Since the convection hole 15 is arranged in the freeze-thaw bag area 21 of the chamber 2, and the channel 6 is communicated with the convection hole 15, therefore, the heat exchange and circulation between the freeze-thaw bag area 21 and the outside of the chamber 2 can be realized quickly and fully, and the heat exchange and circulation between the pipe body area 22 and the outside of the chamber 2 can also be realized quickly and fully, so as to realize the quick exchange and full circulation of heat among the outside of the chamber 2, the freeze-thaw bag area 21 and the pipe body area 22, and further promote the uniformity of the heat received by the freeze-thaw bag 3, the pipe body 4 and the biological liquid inside, and is beneficial to the uniform heating and intactness of the freeze-thaw bag 3, the pipe body 4 and the biological liquid inside.

[0101] Of course, the convection hole 15 is not only arranged at the position corresponding to the channel 6, but also can be arranged at any position.

[0102] As shown in Figure 2 The periphery 151 of the convection hole is recessed towards the direction of the outer surface 12, so that the surface of the freeze-thaw bag 3 and the convection hole 15 will have a circulation space left as the freeze-thaw bag 3 extends into it. When the periphery of the convection hole 15 is smoothly transitioned with the bottom 13 of the shell, the freeze-thaw bag 3 will completely fit on the convection hole 15, so that there will be no gap between the convection hole 15 and the inner surface 11 of the shell, that is, more heat can only be transmitted to the freeze-thaw bag 3 through the area opposite to the convection hole 15, but it is difficult to penetrate into the chamber 2 through the convection hole 15 for heat exchange. When the periphery 151 of the convection hole 15 is recessed, as the freeze-thaw bag 3 extends into the recessed area of the periphery 151 of the convection hole, it will not completely fit in the recessed area, and the recessed area will have a heat circulation space left, so that heat can enter the chamber 2 through the periphery 151 of the convection hole 15 in more areas, rather than being limited to the area corresponding to the convection hole 15, which is beneficial to the quick exchange and full circulation of heat inside and outside the chamber 2.

[0103] The inner surface 11 of the shell is formed with a plurality of buffer portions 16 which are protruded from the inner surface 11 towards the outer surface 12, thereby forming receiving gaps for the partial extension of the freeze-thaw bag 3, and the buffer portions 16 are arranged alternately with the convection holes 15. On one hand, the structural firmness of the bottom 13 of the shell can be ensured, and the structural mechanical strength of the shell is not reduced due to the arrangement of the convection holes 15. On the other hand, since the buffer portions 13 are a plurality of buffer portions 13, the shell is divided into a plurality of parts from the whole, which is also conducive to the deformation of the shell and is suitable for the volume expansion of the freeze-thaw bag 3 in the freezing process. Specifically, in the embodiment, the buffer portions 16 extend along the width direction of the shell, both ends of the buffer portions 16 are located in the channel 6, and the convection holes 15 are located between the adjacent two buffer portions 16. The buffer portions 16 are in the form of grooves, and the grooves are thin and long. The flow-through space 161 is left between the surface of the freeze-thaw bag 3 and the bottom of the buffer portion 16 as the freeze-thaw bag 3 extends.

[0104] When the buffer portion 16 in the form of a groove is not arranged, the surface of the freeze-thaw bag 3 is completely attached to the inner surface 11 of the shell, and there is no flow-through gap between the two at this time. Even if heat enters the cavity 2 through the convection hole 15, it cannot flow to more areas of the surface of the freeze-thaw bag 3. Compared with the smooth bottom, after the buffer portion 16 is arranged, since it is a thin and long groove structure, as shown in Figure 5 , even if the freeze-thaw bag 3 tends to extend into the buffer portion 16, the extending part of the freeze-thaw bag 3 in the actual process cannot completely attach to the surface of the buffer portion 16, so that the flow-through space 161 will exist between the two, and heat can be exchanged and circulated in the flow-through space 161, so that the freeze-thaw bag 3 is uniformly heated. Since the buffer portion 16 and the convection hole 15 are arranged alternately, the heat exchange and circulation inside and outside the cavity 2 are promoted, and the heat exchange and circulation in the flow-through space 161 are also promoted, which further promotes the sufficiency of heat exchange and circulation. Moreover, the heat entering the cavity 2 through the channel 6 or the convection hole 15 is more likely to accumulate in the buffer portion 16, so that the thawing efficiency of the freeze-thaw bag 3 is higher.

[0105] As shown in Figure 1 , Figure 2As shown, the inner surface 11 of the shell is provided with a heat flow cavity 17, which is provided corresponding to the passage 6, or the heat flow cavity 17 is provided corresponding to the convection hole 15, or the heat flow cavity 17 is provided corresponding to both the passage 6 and the convection hole 15. Of course, the heat flow cavity 17 is not limited to being provided at the positions corresponding to the convection hole 15 and the passage 6, but can be provided at any desired position. The heat flow cavity 17 is protruded from the inner surface 11 towards the outer surface 12 and has an opening facing the inner surface 11, so that heat can flow from the convection hole 15 or the passage 6 to the heat flow cavity 17, or heat in the heat flow cavity 17 flows to the convection hole 15 and the passage 6, so that the heat exchange and circulation in the cavity 2 are sufficient, thereby promoting the uniformity of the heating of the freeze-thaw bag 3, the pipe body 4 and the biological liquid in the pipe body 4, and facilitating the uniform heating of the freeze-thaw bag 3, the pipe body 4 and the biological liquid in the pipe body 4 while maintaining the integrity.

[0106] As shown in Figure 3 , Figure 6 As shown, the outer surface 12 of the shell is protruded towards the direction away from the outer surface 12 to form a second partition 121, which is higher than the edge portion 14, that is, when the outer surface 12 of the shell is placed downward on a horizontal surface, the second partition 121 is in contact with the horizontal surface, avoiding the edge portion 14 from contacting the horizontal surface to block the heat, so that there is a gap between the edge portion 14 and the horizontal surface and a gap between the outer surface of the shell and the horizontal surface, promoting the heat to enter the outer surface 12 of the shell through the gap between the edge portion 14 and the horizontal surface and quickly contact the outer surface 12 of the shell, so that the heat can quickly realize the heat exchange and circulation exchange in and out of the cavity 2 through the convection hole 15 and the like.

[0107] In the present embodiment, the heat flow cavity 17 described above is formed by the second partition 121, that is, the second partition 121 is protruded from the inner surface 11 towards the outer surface 12 and has a hollow interior to form the heat flow cavity 17.

[0108] As shown in Figure 7 As shown, the shell is protruded from the outer surface 12 towards the inner surface 11, in other words, the bottom 13 of the shell is not a horizontal structure, but an upward protruding structure. During the freezing process, the freezing speed of the biological liquid in the middle portion of the freeze-thaw bag 3 is slower than that of the biological liquid in the peripheral portion of the freeze-thaw bag 3, so the biological liquid in the middle portion of the freeze-thaw bag 3 has a curved shape (egg-shaped effect), which causes the freezing progress of the freeze-thaw bag 3 to be uneven. Such unevenness is harmful to the freezing process of the protein of the biological liquid. By protruding the bottom 13 towards the cavity 2, the shell restricts the middle portion of the freeze-thaw bag 3, which reduces the "egg-shaped effect" and facilitates the synchronous uniformity of the freezing progress.

[0109] Compared with the outer diameter of the pipe body 4, the thickness of the freeze-thaw bag 3 is larger, and the pipe body 4 is fixedly connected at the middle position of the thickness of the freeze-thaw bag 3. In the natural drooping state of the pipe body 4, there is a large difference between the connection of the freeze-thaw bag 3 and the pipe body 4 and the liquid outlet end 41 of the pipe body 4, which causes the connection of the two to be subjected to a large pulling force. In order to prevent the above-mentioned pulling force from having an adverse effect on the connection of the freeze-thaw bag 3 and the pipe body 4, a supporting portion 18 is arranged in the chamber 2 corresponding to the connection of the freeze-thaw bag 3 and the pipe body 4. The supporting portion 18 forms a stable supporting action on the connection of the two, and at the same time, a flow space is left between the pipe body 4 and the bottom 13 of the shell, so that heat can be quickly circulated and exchanged at the connection of the two.

[0110] As shown in Figure 4 , a freeze-thaw system includes a freeze-thaw bag 3, a pipe body 4 connected to the freeze-thaw bag 3, and the above-mentioned structure of the shell. In this embodiment, the number of shells is one, and the top of the chamber 2 is open. Of course, the shells can also cooperate with other objects outside to form the chamber 2, and the specific limitation is not limited.

[0111] The freeze-thaw bag 3 has a holding portion 31 connected to the abutting section 141, thereby forming a fixed cooperation between the freeze-thaw bag 3 and the shell, avoiding the movement and impact of the freeze-thaw bag 3 to cause damage, and forming an effective protection effect on the freeze-thaw bag 3. Of course, the holding portion 31 can also be connected to the partition 5, or the holding portion 31 is connected to both the abutting section 141 and the partition 5, thereby forming a stable fixed cooperation between the freeze-thaw bag 3 and the shell.

[0112] Embodiment two

[0113] As shown in Figures 8-11 , in this embodiment, the freeze-thaw system includes a freeze-thaw bag 3, a pipe body 4 connected to the freeze-thaw bag 3, and two shells. The inner surfaces 11 of the two shells are oppositely arranged, so that the chambers 2 of the two shells are spliced to form a containing cavity 20, and the freeze-thaw bag 3 and the pipe body 4 are arranged in the containing cavity 20, that is, the two shells can fully and stably hold the freeze-thaw bag 3.

[0114] At this time, the concave-convex limiting areas 51 of the two shell partitions 5 are arranged in opposite directions, so that the concave-convex limiting areas 51 cooperate with each other to form a stable limiting structure, avoiding the dislocation of the two shells during splicing caused by the random movement of the two shells in the width direction and the length direction, thereby causing the structure between the two shells to be blocked or overlapped, and further causing the heat to be blocked.

[0115] That is, the partition 5 plays a role of partitioning the freeze-thaw bag 3 and the pipe body 4, and also plays a good supporting and limiting role. When the inner surfaces 11 of the two shells are oppositely arranged, the partition 5 can oppositely form supports upward and downward, so that the two cavities 2 are combined to form the containing cavity 20, and at the same time, the concave-convex limiting area 51 of the partition 5 cooperatively forms a limiting, so as to ensure that the two shells do not deviate in the width direction and the length direction during use.

[0116] In the embodiment, the holding part 31 is a skirt structure fixedly connected to the outer periphery of the freeze-thaw bag 3, which extends into the abutting sections 141 of the two shells and is firmly clamped thereby to form a stable fixed connection cooperation.

[0117] The specific structure of the shell is the same as that of Embodiment One, and will not be described again.

[0118] Embodiment Three

[0119] Continuing to refer to Figures 8-13 In the embodiment, the edge part 14 of the shell is formed with a first shape part 191 and a second shape part 192 oppositely arranged. When the outer surfaces 12 of the two shells are oppositely arranged, the first shape part 191 and the second shape part 192 are complementary, thereby forming a limiting cooperation, avoiding the misalignment of the two shells during the combination caused by the random movement of the shells, thereby causing the blocking or overlapping of the structures between the two shells, and further causing the blocking of the heat.

[0120] Specifically, the first shape part 191 protrudes from the end surface of the edge part 14 in the height direction, that is, the first shape part 191 is higher than the edge part 14, and it is recessed from the side surface of the edge part 14, and the second shape part 192 is lower than the edge part 14, and it is also recessed from the side surface of the edge part 14.

[0121] Since the first shape part 191 and the second shape part 192 of the two shells are oppositely arranged, when the outer surfaces of the two shells are oppositely arranged to form a stack, the first shape part 191 can be inserted into the second shape part 192, thereby forming a limiting cooperation of the two shells in the length direction and the width direction, avoiding the random movement of the shells in the width direction and the length direction, and when the shells are stacked upward and downward, the overall cooperation structure is more stable.

[0122] The specific structure of the shell is the same as that of Embodiment One, and will not be described again.

[0123] Embodiment Four

[0124] In the present embodiment, on the basis of Embodiment Three, when the outer surfaces 12 of the two housings are arranged opposite to each other, in addition to the first shape part 191 and the second shape part 192 forming the limiting fit, the concave-convex limiting area of the end of the second partition part 121 also forms the limiting fit, and the specific fit structure is the same as that of the concave-convex limiting area 51 of the partition part 5 in Embodiment Two, and thus will not be described again.

[0125] Embodiment Five

[0126] As shown in the figure, in the present embodiment, the edge part 14 of the housing is not formed with the first shape part 191 and the second shape part 192. Figures 14-20

[0127] The freeze-thaw system comprises a freeze-thaw bag 3, a pipe body 4 connected with the freeze-thaw bag 3, and two housings, the inner surfaces 11 of the two housings being arranged opposite to each other, so that the cavities 2 of the two housings are combined to form a containing cavity 20, and the freeze-thaw bag 3 and the pipe body 4 are arranged in the containing cavity 20.

[0128] When the outer surfaces 12 of the two housings are arranged opposite to each other to form stacking, the concave-convex limiting area of the second partition part 121 forms the limiting fit, and the specific fit structure is the same as that of the concave-convex limiting area 51 of the partition part 5 in Embodiment Two, and thus will not be described again. At the same time, the concave part of the concave-convex limiting area of the second partition part 121 is flush with the edge part 14, so that when the outer surfaces 12 of the two housings are arranged opposite to each other, the edge part 14 can be overlapped up and down to form a stable supporting effect.

[0129] The other specific structures of the housing are the same as those in Embodiment One, and thus will not be described again.

[0130] Embodiment Six

[0131] As shown in the figure, in the present embodiment, the number of the pipe body 4 is two, and they are located on the same side of the freeze-thaw bag 3, and the other structures are the same as those in Embodiment One, and thus will not be described again. Figure 21 Embodiment Seven

[0132] As shown in the figure, in the present embodiment, the number of the pipe body 4 is one, and it is located on one side of the freeze-thaw bag 3, and the other structures are the same as those in Embodiment One, and thus will not be described again. In other embodiments, the partition part can also be arranged on only one side of the housing.

[0133] Figure 22 Embodiment Eight

[0134] As shown in the figure, in the present embodiment, the number of the pipe body 4 is one, and it is located on one side of the freeze-thaw bag 3, and the other structures are the same as those in Embodiment One, and thus will not be described again. In other embodiments, the partition part can also be arranged on only one side of the housing.

[0135] As shown in the figure, in the present embodiment, the number of the pipe body 4 is one, and it is located on one side of the freeze-thaw bag 3, and the other structures are the same as those in Embodiment One, and thus will not be described again. In other embodiments, the partition part can also be arranged on only one side of the housing. Figures 23-24 ​​As shown, the freeze-thaw bag 3 specifically comprises a bag body 32 and a holding portion 31 connected to the bag body 32, the holding portion 31 extends to the abutting section 141 of the shell and is fixedly matched with the abutting section 141 by any means known to those skilled in the art such as screwing, lacing and bonding (the fixed matching between the holding portion 31 and the abutting section 141 of the shell includes various cases, in some embodiments, the holding portion 31 is only fixedly matched with the abutting section 141 of one shell; in other embodiments, the holding portion 31 is clamped between two shells and fixedly matched with the abutting section 141); in other embodiments, the holding portion 31 extends to the partition section 5 of the shell and is fixedly matched with the partition section 5 by any means known to those skilled in the art such as screwing, lacing and bonding (the fixed matching between the holding portion 31 and the partition section 5 of the shell includes various cases, in some embodiments, the holding portion 31 is only fixedly matched with the partition section 5 of one shell; in other embodiments, the holding portion 31 is clamped between two shells and fixedly matched with the partition section 5). The fixed matching is conducive to avoiding the movement and impact of the bag body 32, preventing the damage of the bag body 32, and effectively protecting the bag body 32; at the same time, since the abutting section 141 is part of the edge section 14 and extends away from the bottom 13, or the partition section 5 is in the cavity 2 and can separate the bag body 32 and the tube body 4, the abutting section 141 and the partition section 5 protrude relative to the bottom 13 of the shell, i.e., there is a certain space between the holding portion 31 and the bottom 13 of the shell, so that the tensile force between the holding portion 31 and the bag body 32 has a certain space with the bottom 13 of the shell, thereby facilitating the reduction of the expansion degree of the bag body 32, especially the middle part of the bag body 32, towards the bottom 15 of the shell during the freezing expansion process, and the uniformity of the thickness of each part of the bag body 32 after expansion, thereby facilitating the uniform freezing of the bag body 32.

[0136] Specifically, the bag body 32 comprises a side wall 321 containing the material liquid, the side wall 321 comprises at least two side edges 322, adjacent side edges 322 extend to form an intersection 323, and the holding portion 31 is connected to at least two oppositely arranged intersections 323. The bag body 32 can be a planar bag or a three-dimensional bag, and at least two side edges 322 can be formed on the planar bag or the three-dimensional bag, and adjacent side edges 322 can extend to form an intersection 323, which can be a point, a line or a surface; the holding portion 31 is connected to at least two oppositely arranged intersections 323, i.e., two opposite intersections 323 can provide balanced and stable tensile force to the bag body 32. The connection mode of the holding portion 31 and the at least two oppositely arranged intersections 323 includes that, in some embodiments, the holding portion 31 is connected only to the intersection 323; or in other embodiments, the holding portion 31 can be connected to the intersection 323 and the side wall 321 and / or the side edge 322 of the bag body 32 extended from the intersection 323.

[0137] In other embodiments, further, the holding portion 31 forms the connecting portion 7 at the abutment portion 323 with the abutting section 141 and / or the partition portion 5, and the holding portion 31 is fixedly fitted with two oppositely arranged abutment portions 323 to provide balanced and stable tension to the bag body 32, and the holding portion 32 is spaced apart from the abutting section 141 and / or the partition portion 5 to allow the bag body 32 to accommodate the expanded volume, so that the balanced and stable tension can be provided to the bag body 32, and the expansion of the bag body 32, especially the middle portion of the bag body 32, towards the bottom 13 of the shell during the freezing expansion is reduced, and the thickness uniformity of the bag body 32 after expansion is improved, so that the freezing of the bag body 32 is uniform.

[0138] In other embodiments, further, the connecting portion 7 is provided with an intermittent portion 71, i.e., the connecting portion 7 has a notch, and the bag body 32 is more easily deformed at the intermittent portion 71 when the volume of the biological material in the bag body 32 expands after freezing, so that the damage to the biological material in the bag body 32 caused by the twisting and bending of the bag body 32 driven by the connecting portion 7 is reduced, and the freezing expansion process of the bag body 32 is facilitated.

[0139] In other embodiments, further, the intermittent portion 71 includes two side edges 72 extending and intersecting to form an included angle 73, and the included angle 73 ranges from 90° to less than 180°. When the included angle 73 ranges from 90° to less than 180°, i.e., the ends of the adjacent side edges 72 extend in a direction away from each other, the tension of the connecting portion 7 on the bag body 32 is multi-point, and the uniformity of the tension of the connecting portion 7 on the bag body 32 is improved while a small number of connecting portions 7 are used.

[0140] In other embodiments, further, the vertex of the included angle 73 is arc-shaped, and / or the vertex of the included angle 73 and the side wall 321 of the bag body 32 form a connecting area 74 surrounding the side wall 321 of the bag body 32. When the bag body 32 expands, the arc-shaped vertex of the included angle 73 facilitates reducing the tearing of the connecting portion 7 at the intermittent portion 71 along the opening of the included angle 72 and then to the bag body 32, and the vertex of the included angle 73 and the side wall 321 of the bag body 32 form the connecting area 74 surrounding the side wall 321 of the bag body 32, so that the connecting area between the connecting portion and the bag body 32 is increased, and the breakage or damage at the connecting portion and the side wall 321 of the bag body 32 is avoided.

[0141] The other structures and embodiments are the same as those in Embodiment 1, and will not be described again.

[0142] Example 9

[0143] like Figure 25 As shown, in this embodiment, the retaining part 31 does not have an interruption 71, a side 72, or an included angle 73.

[0144] The other structures are the same as in Example 8, and will not be described again.

[0145] Example 10

[0146] like Figures 26-27 As shown, the bag 32 has a cavity 8 when unloaded. During freezing, as the bag 32 expands, the biological liquid is driven to concentrate in the middle of the bag 32 under gravity, causing the middle of the bag 32 to expand too much compared to the periphery. This pushes the corresponding middle part of the shell to expand towards the outer surface, increasing the hollow space in the middle of the shell. This, in turn, causes the biological liquid to flow towards the middle of the bag 32 under gravity, increasing the amount of biological liquid carried in the middle of the shell. Consequently, the middle of the shell is subjected to excessive pressure and expands further towards the outer surface. This causes the biological liquid to continue flowing towards the middle of the corresponding bag 32 in the shell, resulting in excessive expansion of the middle of the bag 32 compared to the periphery, leading to uneven freezing. At the same time, there are bends and wrinkles at the transition point between the middle and periphery of the bag 32, which damage the biological liquid. Furthermore, the excessive expansion of the bag 32 can reduce its strength and cause it to break. However, if the size of the bag 32 is increased, the excess size will form many wrinkles and bends when the bag 32 is assembled into the shell cavity, which will damage the biological liquid inside the bag 32 during freezing. Therefore, when the bag 32 is empty, that is, when there is no material inside the bag 32, there is a cavity. At this time, the bag 32 is a three-dimensional bag, which includes two structures: the bag 32 can be a 3D bag with a cavity inside; or the sidewalls of the bag 32 can be wrinkled, that is, even when the sidewalls of the bag 32 are attached, multiple cavities will be formed at the wrinkles due to irregular folding (this structure can be formed by pre-stretching and shaping along the thickness direction of the sidewall, which is well known to those skilled in the art, and will not be described in detail here). The above-mentioned bag 32 structure increases the filling amount of the bag 32 into the cavity of the shell, which is beneficial to balance the filling amount of the bag 32 with the uniformity of the freezing process and the strength of the bag 32.

[0147] The above specific embodiments are used to explain and illustrate the present invention, but not to limit the present invention. Any modifications and changes made to the present invention within the spirit and scope of the claims shall fall within the protection scope of the present invention.

Claims

1. A housing to contain a freeze-thaw bag, having an inner surface and an outer surface, characterized by: The inner surface forms a chamber for simultaneously accommodating the freeze-thaw bag and the pipe body connected with the freeze-thaw bag; the chamber is divided into a freeze-thaw bag area for accommodating the freeze-thaw bag and a pipe body area for accommodating the pipe body, and has a partition between the freeze-thaw bag area and the pipe body area, and a passage is arranged in the chamber near the partition to communicate the freeze-thaw bag area and the pipe body area; the shell comprises a bottom defining the chamber and an edge portion surrounding the chamber, the edge portion comprises an abutting section extending away from the bottom and a notch section corresponding to the pipe body area to facilitate the pipe body to enter and exit the chamber from the inside and outside; the notch section communicates with the passage; the shell is convex from the outer surface to the inner surface; the inner surface of the shell forms a buffer portion which is convex from the inner surface to the outer surface in a groove shape, and a flow space is left between the surface of the freeze-thaw bag and the bottom of the buffer portion as the freeze-thaw bag extends into the chamber.

2. A housing for a freeze-thaw bag according to claim 1, wherein: The number of the partitions is multiple, adjacent partitions are independent of each other, and the passage is formed between adjacent partitions.

3. A housing for a freeze-thaw bag according to claim 2, wherein: The shell is provided with a convection hole for communicating the inside and outside of the chamber, the convection hole communicates with the passage; the periphery of the convection hole is recessed in the direction of the outer surface, and a flow space is left between the surface of the freeze-thaw bag and the convection hole as the freeze-thaw bag extends into the chamber.

4. A housing for a freeze-thaw bag according to claim 3, wherein: The buffer portion is multiple to form an accommodation gap for the partial extension of the freeze-thaw bag, and the buffer portion is arranged alternately with the convection hole.

5. A housing for a freeze-thaw bag according to claim 4, wherein: The inner surface of the shell is provided with a heat flow passage corresponding to the passage and / or the convection hole.

6. A housing for a freeze-thaw bag according to any one of claims 1-5, characterized in that: The outer surface of the shell is convex in the direction away from the outer surface to form a second partition which is higher than the edge portion.

7. The housing for a freeze-thaw bag of claim 1, wherein: A supporting portion is arranged in the chamber corresponding to the connection of the freeze-thaw bag and the pipe body to leave a flow space between the pipe body and the bottom.

8. A housing for a freeze-thaw bag according to claim 1 or 2, wherein: The partition is convex from the inner surface of the shell, and a concave-convex limiting area is formed at the end away from the inner surface.

9. The housing for a freeze-thaw bag of claim 1, wherein: A limiting elastic member is arranged in the pipe body area and abuts against the pipe body.

10. The housing for a freeze-thaw bag of claim 2, wherein: The shell has a cuboid structure, and at least two partitions are arranged on opposite sides of the shell.

11. A freeze-thaw system characterized by: The shell comprises a freeze-thaw bag, a pipe body connected with the freeze-thaw bag, and a shell as claimed in any one of claims 1-10.

12. The freeze-thaw system of claim 11, wherein: The inner surfaces of two shells are arranged oppositely to make two chambers combine to form an accommodation chamber, and the freeze-thaw bag and the pipe body are simultaneously arranged in the accommodation chamber.

13. The freeze-thaw system of claim 11 or 12, wherein: The freeze-thaw bag comprises a bag body and a holding portion connected with the bag body, the holding portion is connected with the abutting section and / or the partition to form a fixed cooperation between the bag body and the shell.

14. The freeze-thaw system of claim 13, wherein: The bag body comprises a side wall for accommodating a liquid, the side wall comprises at least two side edges, and adjacent side edges are extended to form an intersection portion, and the holding portion is connected with at least two oppositely arranged intersection portions.

15. The freeze-thaw system of claim 14, wherein: At the intersection portion, the holding portion and the abutting section and / or the partition form a connection portion in fixed cooperation.

16. The freeze-thaw system of claim 15, wherein: The periphery of the connection portion is provided with an intermittent portion.

17. The freeze-thaw system of claim 16, wherein: The intermittent portion comprises two side edges, the two side edges are extended and intersected to form an included angle θ, and the included angle ranges from 90° to less than 180°.

18. The freeze-thaw system of claim 17, wherein: The vertex of the included angle is arc-shaped; and / or, a connection area is formed between the vertex of the included angle and the side wall of the bag body, and the connection area surrounds the side wall of the bag body.

19. The freeze-thaw system of claim 13, wherein: The bag has a cavity in an empty state.

20. The freeze-thaw system of claim 11, wherein: The edge part of the shell is formed with a first shape part and a second shape part arranged at intervals, and the first shape part and the second shape part are complementary to form a limiting fit when the outer surfaces of the two shells are arranged oppositely.

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