A nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester and a preparation method thereof

Abstract

The present invention provides a nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester and a preparation method thereof. The nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester comprises the following components in parts by mass: 5-20 parts of glycerol, 5-10 parts of propylene glycol, 1-5 parts of modified silica, 1-5 parts of cyclomethicone, 1-5 parts of vegetable oil, 1-5 parts of active ingredient, 1-5 parts of acetyl dipeptide-1 cetyl ester, 1-5 parts of auxiliary agent, and a solvent; wherein, the modified silica is cetearyl alcohol polyoxyethylene ether modified silica. The present invention adopts modified silica and is compounded with components such as acetyl dipeptide-1 cetyl ester, which not only improves the stability of the emulsion, but also endows the product with sustained release performance, thereby better realizing the skin care effect and overcoming the defects existing in the prior art.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and particularly relates to a nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester and a preparation method thereof. Background Art

[0002] With the development of the times and the rise of the consumption level, consumers' demand for skin care is also getting higher and higher. How to efficiently and durably achieve skin moisturization, protection, and at the same time slow down skin aging has become a hot topic in current research.

[0003] Acetyl dipeptide-1 cetyl ester is a new type of effective skin care and anti-aging ingredient, which is beneficial to stimulating the synthesis of elastin, has the effects of combating skin relaxation, anti-allergy and soothing. At the same time, due to the introduction of acetyl group and cetyl ester group, this ingredient has good transdermal absorption performance. After being compounded with other components, it can achieve better moisturizing, whitening, and anti-aging effects.

[0004] However, after acetyl dipeptide-1 cetyl ester is compounded with other ingredients, there is a problem of insufficient compatibility. After long-term storage, the properties may change, and the emulsion products will also show phenomena such as turbidity, stratification, and precipitation, which not only affect the appearance of the products, but also cause problems such as reduced effects of active ingredients and difficulty in absorption, and urgently need to be improved.

[0005] In summary, it is necessary to develop a new technical solution to solve the problems existing in the prior art. Summary of the Invention

[0006] To solve the deficiencies in the prior art, the present invention provides a nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester and a preparation method thereof. The present invention uses modified silica, compounded with ingredients such as acetyl dipeptide-1 cetyl ester, which not only improves the stability of the emulsion, but also endows the product with sustained release performance, thus better achieving the skin care effect and overcoming the defects existing in the prior art.

[0007] An object of the present invention is to provide a nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester, and the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester comprises the following components in parts by mass:

[0008]

[0009]

[0010] Solvent;

[0011] Wherein,

[0012] The modified silica is cetearyl alcohol polyoxyethylene ether modified silica.

[0013] Further, the vegetable oil is selected from one or more of almond oil, jojoba oil, shea butter, olive oil, coconut oil, and camellia seed oil.

[0014] Further, the active ingredient is selected from one or more of animal extracts, plant extracts, vitamins, amino acids, enzymes, and polypeptides.

[0015] Further, the auxiliary agent is selected from one or more of humectants, thickeners, surfactants, preservatives, antioxidants, emulsifiers, stabilizers, cosolvents, pH regulators, flavors, and pigments.

[0016] Another object of the present invention is to provide a method for preparing the above nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester. The method for preparing the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester includes the following steps:

[0017] S1. Blend silica and cetostearyl alcohol polyoxyethylene ether, and after ultrasonic heating reaction, obtain modified silica;

[0018] S2. Mix the modified silica, acetyl dipeptide-1 cetyl ester, and a solvent, after ultrasonic treatment, add other components, and stir evenly to obtain the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester.

[0019] Further, in step S1, the silica is hydroxylated.

[0020] Further, in step S1, the temperature of the ultrasonic heating reaction is 30-60°C, and the time is 1-3 h.

[0021] Further, in step S1, the mass ratio of silica to cetostearyl alcohol polyoxyethylene ether is 1:(0.5-3).

[0022] Further, in step S2, the time of ultrasonic treatment is 0.1-1 h.

[0023] The present invention has the following beneficial effects:

[0024] In the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester of the present invention, modified silica is used as a component. First, the silica is hydroxylated, and then it is mixed and reacted with cetearyl polyoxyethylene ether. Through the strong polar ethoxy chain forming hydrogen bonds and intermolecular forces with the hydroxyl groups on the silica surface, adsorption and crosslinking are achieved, thereby introducing a surfactant-like chain segment on the silica surface. On the one hand, the dispersibility of silica is enhanced and the stability of the emulsion is improved; on the other hand, the modified silica surface has more active sites, better compatibility with active substances, and the long alkyl chains on the surface can entangle and combine with components such as acetyl dipeptide-1 cetyl ester, achieving the effects of slowing down the release rate and improving stability. Under the action of surfactants, it can adhere more uniformly to the skin surface and exert moisturizing and maintenance effects persistently. Based on this, the emulsion of the present invention effectively avoids the possibility of inactivation and denaturation of active components, and also realizes the function of sustained release, having good application prospects. Detailed Embodiments

[0025] The following specific examples are used to further illustrate the present invention, but the examples do not limit the present invention in any form. Unless otherwise specified, the reagents, methods, and equipment used in the present invention are conventional reagents, methods, and equipment in the technical field.

[0026] Unless otherwise specified, the reagents and materials used in the following examples are all commercially available.

[0027] The cetearyl polyoxyethylene ether in the examples of the present invention is cetearyl polyoxyethylene ether-8 purchased from Jiangsu Haian Petrochemical Factory.

[0028] The silica in the examples of the present invention is subjected to surface hydroxylation treatment, including the following steps:

[0029] Immerse nano-silica (particle size 10 nm) in a mixed solution of concentrated sulfuric acid and hydrogen peroxide with a volume ratio of 7:3 (the concentration of hydrogen peroxide is 30 wt%), react at 70 °C for 1 h, wash to remove concentrated sulfuric acid and hydrogen peroxide, and dry to obtain the product.

[0030] In the examples of the present invention, "parts" all refer to parts by mass.

[0031] Example 1

[0032] A nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester, comprising the following components in parts by mass:

[0033]

[0034] The preparation method of the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester includes the following steps:

[0035] S1. Using ethyl acetate as a solvent, blend silica and cetearyl alcohol polyoxyethylene ether at a mass ratio of 1:2. After ultrasonic reaction at 30 °C for 2 h, filter, wash, and dry to obtain modified silica;

[0036] S2. According to the above mass fractions, mix the modified silica, acetyl dipeptide-1 cetyl ester, and deionized water, and perform ultrasonic treatment for 0.5 h. Then add other components and stir evenly to obtain the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester.

[0037] Example 2

[0038] A nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester, comprising the following components in mass fractions:

[0039]

[0040] The preparation method of the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester comprises the following steps:

[0041] S1. Using ethyl acetate as a solvent, blend silica and cetearyl alcohol polyoxyethylene ether at a mass ratio of 1:2. After ultrasonic reaction at 40 °C for 1.5 h, filter, wash, and dry to obtain modified silica;

[0042] S2. According to the above mass fractions, mix the modified silica, acetyl dipeptide-1 cetyl ester, and deionized water, and perform ultrasonic treatment for 0.5 h. Then add other components and stir evenly to obtain the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester.

[0043] Example 3

[0044] A nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester, comprising the following components in mass fractions:

[0045]

[0046]

[0047] The preparation method of the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester comprises the following steps:

[0048] S1. Using ethyl acetate as a solvent, blend silica and cetearyl alcohol polyoxyethylene ether at a mass ratio of 1:2. After ultrasonic reaction at 40 °C for 2 h, filter, wash, and dry to obtain modified silica;

[0049] S2. According to the above mass fractions, mix the modified silica, acetyl dipeptide-1 cetyl ester, and deionized water, and perform ultrasonic treatment for 0.5 h. Then add other components and stir evenly to obtain the nano-sustained release emulsion containing acetyl dipeptide-1 cetyl ester.

[0050] Comparative Example 1

[0051] An emulsion. The difference between this comparative example and Example 1 is that in step S1, cetostearyl polyoxyethylene ether is replaced with an equal mass of PEG400, and other components and preparation methods are the same as those in Example 1.

[0052] Comparative Example 2

[0053] An emulsion. The difference between this comparative example and Example 1 is that step S1 is omitted, and modified silica is replaced with an equal mass of unmodified silica, and other components and preparation methods are the same as those in Example 1.

[0054] Test Example

[0055] Performance tests were carried out on the samples obtained in Examples 1 - 3 and Comparative Examples 1 - 2.

[0056] High - temperature stability: 100 mL of the sample was placed in a transparent glass bottle, sealed and placed in a constant - temperature oven at 40 °C. After 45 days, the appearance of the sample was observed.

[0057] Low - temperature stability: 100 mL of the sample was placed in a transparent glass bottle, sealed and placed in a constant - temperature oven at 5 °C. After 45 days, the appearance of the sample was observed.

[0058] Skin - care effect test: 50 volunteers were selected and randomly divided into 5 groups, with 10 people in each group. The samples prepared in Examples 1 - 3 and Comparative Examples 1 - 2 were used respectively. 5 g was taken and applied to the face every morning and evening. After 30 days, the skin - care effect was scored. The scoring content included moisturizing property and persistence, with scores ranging from 0 to 10 points, and 10 points being the best. The average value of the total scores of each group was calculated.

[0059] The test results are shown in Table 1.

[0060] Table 1 Performance test results

[0061]

[0062]

[0063] It can be concluded from Table 1 that the nano - sustained - release emulsion containing acetyl dipeptide - 1 cetyl ester in Examples 1 - 3 of the present invention shows excellent stability after long - term storage, without agglomeration, precipitation or stratification, and has good skin - care performance at the same time; while in Comparative Examples 1 - 2, due to the replacement of modified silica, the compatibility between components is reduced and the synergistic effect is weakened, resulting in a significant decline in both the stability and skin - care effect of the emulsion.

[0064] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications made without departing from the spirit and principle of the present invention shall be equivalent replacement methods and are all included in the protection scope of the present invention.

Claims

1. A nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester, characterized in that: The nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester comprises the following components in parts by mass: Glycerin 5-20 parts Propylene glycol 5-10 parts Modified silica 1-5 parts Cyclomethicone 1-5 parts 1-5 parts vegetable oil Active ingredient 1-5 parts Acetyl dipeptide-1 cetyl ester 1-5 parts 1-5 parts of additives Solvents; in, The modified silicon dioxide is cetearyl alcohol polyoxyethylene ether modified silicon dioxide; The active ingredient is selected from one or more of animal extracts, plant extracts, vitamins, amino acids, enzymes, and polypeptides; The preparation method of the nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester comprises the following steps: S1, using ethyl acetate as solvent, blending silicon dioxide and cetearyl alcohol polyoxyethylene ether, and reacting by ultrasonic heating to obtain modified silicon dioxide; S2, mixing the modified silicon dioxide, acetyl dipeptide-1 cetyl ester and solvent, and after ultrasonic treatment, adding other ingredients and stirring evenly to obtain the nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester; In step S1, the temperature of the ultrasonic heating reaction is 30-60°C and the time is 1-3 h; In step S1, the mass ratio of silicon dioxide to cetearyl alcohol polyoxyethylene ether is 1:(0.5-3); In step S1, the silicon dioxide is subjected to hydroxylation treatment.

2. The nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester according to claim 1, characterized in that: The vegetable oil is selected from one or more of almond oil, jojoba oil, shea butter, olive oil, coconut oil and tea seed oil.

3. The nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester according to claim 1, characterized in that: The auxiliary agent is selected from one or more of a moisturizer, a thickener, a preservative, an antioxidant, an emulsifier, a stabilizer, a cosolvent, a pH regulator, a flavor, and a pigment.

4. The nano sustained-release emulsion containing acetyl dipeptide-1 cetyl ester according to claim 1, characterized in that: In step S2, the ultrasonic treatment time is 0.1-1 h.

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