A rare earth functional glaze for ceramics and its preparation method and application

Abstract

The present invention provides a rare earth functional glaze for ceramics, a preparation method and an application thereof, wherein the glaze comprises a pearlescent material, a color glaze and a LaCe@GdNPs material in a mass ratio of 6:(2-3):(1-2); wherein the LaCe@GdNPs material is prepared using Ce(NO3)3, La(NO3)3 and GdCl3 as raw materials. The rare earth functional glaze for ceramics of the present invention can inhibit the formation of Porphyromonas gingivalis by effectively inhibiting the activity of Porphyromonas gingivalis.

Description

Technical Field

[0001] The invention belongs to the field of ceramic glazes, and in particular relates to a rare earth functional glaze for ceramics and a preparation method and application thereof. Background Art

[0002] With the continuous advancement of modern science and technology, the biomedical field has achieved remarkable development. Especially in the field of oral health, researchers have been exploring new methods and technologies to more effectively prevent and treat oral diseases. Among them, Porphyromonas gingivalis, as one of the main pathogens of periodontal disease, has attracted widespread attention for its negative impact on oral health. Traditional antibacterial treatments, such as the use of antibiotics and antibacterial mouthwashes, can control the growth of bacteria to a certain extent, but long-term use may lead to an increase in bacterial resistance and have an adverse effect on the balance of normal human flora. Therefore, the development of new, safe and effective antibacterial materials has become a hot topic in current research.

[0003] Periodontitis is a chronic inflammatory disease of the oral cavity, and Porphyromonas gingivalis is one of the most common bacteria in periodontitis. The disease is characterized by the destruction of the supporting structures of the teeth (i.e., the gingiva, periodontal ligament, and alveolar bone), and ultimately leads to tooth loss. Smoking and diabetes are major risk factors for periodontitis, and Porphyromonas gingivalis is the main pathogen of implant periodontitis, a periodontal disease characterized by inflammation of the hard and soft tissues surrounding the implant. If left untreated, peri-implantitis can lead to the failure of dental implants. Studies have shown that Porphyromonas gingivalis can induce apoptosis in multiple cells, including fibroblasts, endothelial cells, and lymphocytes. In clinical cases, apoptosis leads to extensive destruction of periodontal tissues.

[0004] Rare earth elements are favored by researchers because of their unique physical and chemical properties. Rare earth elements have excellent antibacterial properties, low toxicity and good biocompatibility, which makes them show great application potential in the biomedical field. In particular, light rare earth elements such as lanthanum (La) and cerium (Ce) have been shown to have significant inhibitory effects on a variety of microorganisms. These elements can effectively inhibit bacterial growth by destroying bacterial cell walls, interfering with bacterial metabolic pathways or affecting bacterial biofilm formation. In view of this, it is necessary to apply rare earth elements to oral materials to reduce the occurrence and development of periodontal disease. Summary of the invention

[0005] In view of this, the present invention aims to propose a rare earth functional glaze for ceramics, a preparation method and application thereof, which releases rare earth ions to inhibit the growth of oral pathogens such as Porphyromonas gingivalis, thereby disinfecting stubborn oral pathogens in the oral cavity and reducing the occurrence and development of periodontal disease.

[0006] To achieve the above object, the technical solution of the present invention is achieved as follows:

[0007] A rare earth functional glaze for ceramics, comprising a pearlescent material, a color glaze and a LaCe@GdNPs material in a mass ratio of 6:(2-3):(1-2); wherein the LaCe@GdNPs material is prepared using Ce(NO3)3, La(NO3)3 and GdCl3 as raw materials.

[0008] Furthermore, the preparation method of LaCe@GdNPs material is: using GdCl3 as raw material, coating the surface with ethyl silicate to form spherical particles, and then preparing nano-gadolinium-loaded lanthanum-cerium spherical particles LaCe@GdNPs material through hydrothermal synthesis with Ce(NO3)3·6H2O and La(NO3)3·6H2O.

[0009] Furthermore, the molar ratio of La(NO3)3·6H2O to Ce(NO3)3·6H2O is 1:(1-5).

[0010] Preferably, the molar ratio of La(NO3)3·6H2O to Ce(NO3)3·6H2O is 1:1.

[0011] Further, La 3+ and Ce 3+ With Gd 3+ The molar ratio is 3:(0.5-2).

[0012] Preferably, La 3+ and Ce 3+ With Gd 3+ The molar ratio is 3:1.

[0013] Furthermore, the pearlescent material includes, by weight: 40-50 parts of quartz, 0.5-1 parts of copper oxide, 0.1-0.5 parts of barium carbonate, 20-30 parts of manganese oxide, 0.1-0.5 parts of magnesium oxide, 0.1-0.5 parts of sodium carbonate, 1-3 parts of ferrosoferric oxide and 5-7 parts of cobalt oxide.

[0014] Preferably, the pearlescent material includes, by weight: 49.59 parts by weight of quartz (SiO2), 0.98 parts by weight of copper oxide (CuO), 0.10 parts by weight of barium carbonate (BaCO3), 29.65 parts by weight of manganese oxide (MnO2), 0.10 parts by weight of magnesium oxide (MgO), 0.20 parts by weight of sodium carbonate (Na2CO3), 2.47 parts by weight of ferrosoferric oxide (Fe3O4) and 6.92 parts by weight of cobalt oxide (Co3O4).

[0015] Furthermore, the colored glaze comprises, by weight: 80-95 parts of dolomite and 5-20 parts of cobalt oxide.

[0016] Preferably, the colored glaze comprises, by weight: 92.1 parts by weight of dolomite and 7.9 parts by weight of cobalt oxide (CoO).

[0017] The present invention also provides a method for preparing the rare earth functional glaze for ceramics as described above, the method comprising the following steps:

[0018] 1) Preparation of LaCe@GdNPs materials

[0019] GdCl3 was used as raw material, and the surface was coated with ethyl silicate to form spherical particles, and then the nano-gadolinium-loaded lanthanum-cerium spherical particles LaCe@GdNPs were prepared by hydrothermal synthesis with Ce(NO3)3·6H2O and La(NO3)3·6H2O.

[0020] 2) Directly mix the pearlescent material, color glaze and LaCe@GdNPs material according to the proportion, stir evenly and it is ready for use.

[0021] Preferably, the pearlescent material, the colored glaze and the LaCe@GdNPs material are mixed in an addition ratio of 6:3:1.

[0022] The present invention also provides an application of the rare earth functional glaze for ceramics as described above in oral antibacterial treatment, wherein the glaze is used for disinfecting stubborn Porphyromonas gingivalis in the oral cavity.

[0023] Compared with the prior art, the rare earth functional glaze for ceramics and its preparation method and application described in the present invention have the following advantages:

[0024] The rare earth functional glaze for ceramics of the present invention can effectively inhibit the formation of Porphyromonas gingivalis biofilm by highly effective inhibition of Porphyromonas gingivalis. Rare earth elements are embedded in ceramics through a specific process, and these ceramics can not only release a controllable amount of rare earth ions, but also form a protective film on the surface of teeth to prevent the attachment and growth of bacteria. This dual effect greatly improves the antibacterial effect and reduces the incidence of periodontal disease. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The accompanying drawings constituting a part of the present invention are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0026] Figure 1 This is a photograph of the culture medium for the antibacterial experiment of the glaze containing LaCe@GdNPs at different concentrations on Porphyromonas gingivalis in Example 1 of the present invention;

[0027] Figure 2 It is a statistical diagram of the antibacterial rate of different rare earth functional glazes against Porphyromonas gingivalis in the examples of the present invention and the comparative examples;

[0028] Figure 3 Statistical graphs showing the antibacterial rates of different rare earth functional glazes against Porphyromonas gingivalis and Escherichia coli in Examples 1-3 of the present invention. DETAILED DESCRIPTION

[0029] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0030] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods described, unless otherwise specified, are all conventional methods.

[0032] Cerium nitrate hexahydrate (Ce(NO3)3·6H2O), lanthanum nitrate hexahydrate (La(NO3)3·6H2O), and gadolinium chloride (GdCl3) were purchased from Shandong Desheng New Materials Co., Ltd. Quartz (SiO2), copper oxide (CuO), barium carbonate (BaCO3), manganese oxide (MnO), magnesium oxide, sodium carbonate (Na2CO3), ferrous oxide (Fe3O4), cobalt oxide (Co3O4), dolomite, cobalt oxide (CoO), amber and pearl amber were purchased from Hebei Longfengshan Furnace Material Co., Ltd. Ammonium bicarbonate (NH4HCO3), nitric acid (HNO3), N,N-dimethylformamide (DMF), triethylamine (TEA) and sodium hydroxide (NaOH) were purchased from Beijing Chemical Plant (Beijing, China), with a purity of more than 99%. TSA and 5% defibrinated sheep blood, tryptone (tryptic digest of casein), yeast extract, soy peptone (papain digest of soybean powder), sodium chloride, and agar were purchased from Aladdin Reagent Co., Ltd. All chemicals were used without further treatment, and distilled water (ρ = 18.2 MΩ•cm, 25°C) was from Millipore milli-Q water purification system. Escherichia coli and Porphyromonas gingivalis were from Beijing Sihuan Biopharmaceutical Co., Ltd.

[0033] Example 1

[0034] A rare earth functional glaze for ceramics is prepared by the following method:

[0035] 1) Preparation of gadolinium oxide precursor

[0036] Weigh 100 g of GdCl3 and add it to 100 mL of ethyl silicate, then add 30 mL of deionized water and 30 mL of DMF, use magnetic stirring to fully dissolve, then add 9 mL of triethylamine, continue stirring at 100 ° C for 6 hours to obtain a mixed suspension solution; then obtain the precipitate by centrifugation at 11000 rpm / 15 min, and freeze-dry the collected precipitate to obtain a gadolinium oxide precursor for use.

[0037] 2) Preparation of LaCe@GdNPs materials

[0038] Weigh 12.14 g of the intermediate gadolinium oxide precursor prepared in step 1), add 100 mL of deionized water, and then add 43 g of Ce(NO3)3·6H2O and 43 g of La(NO3)3·6H2O. Stir for 20 min to mix evenly and then transfer to a hydrothermal reactor. Then react at 220°C for 18 h, dry at 80°C to remove moisture, and then calcine at 700°C in a muffle furnace for 3 hours to obtain nano-gadolinium oxide-loaded lanthanum-cerium spherical particles LaCe@GdNPs material.

[0039] 3) Preparation of glaze

[0040] Weigh the following raw materials of pearlescent material by weight: 49.59 parts by weight of quartz (SiO2), 0.98 parts by weight of copper oxide (CuO), 0.10 parts by weight of barium carbonate (BaCO3), 29.65 parts by weight of manganese oxide (MnO2), 0.10 parts by weight of magnesium oxide (MgO), 0.20 parts by weight of sodium carbonate (Na2CO3), 2.47 parts by weight of ferrosoferric oxide (Fe3O4) and 6.92 parts by weight of cobalt oxide (Co3O4);

[0041] Weigh the glaze raw materials by weight: 92.1 parts by weight of dolomite and 7.9 parts by weight of cobalt oxide (CoO);

[0042] The pearlescent material, colored glaze and LaCe@GdNPs material were mixed in a mass ratio of 6:3:1 to prepare the rare earth functional glaze.

[0043] Example 2

[0044] A rare earth functional glaze for ceramics is prepared by the following method:

[0045] 1) Preparation of gadolinium oxide precursor

[0046] Weigh 100 g of GdCl3 and add it to 100 mL of ethyl silicate, then add 30 mL of deionized water and 30 mL of DMF, use magnetic stirring to fully dissolve, then add 9 mL of triethylamine, continue stirring at 100 ° C for 6 hours to obtain a mixed suspension solution; then obtain the precipitate by centrifugation at 11000 rpm / 15 min, and freeze-dry the collected precipitate to obtain a gadolinium oxide precursor for use.

[0047] 2) Preparation of LaCe@GdNPs materials

[0048] Weigh 12.14 g of the intermediate gadolinium oxide precursor prepared in step 1), add 100 mL of deionized water, then add 43 g of La(NO3)3·6H2O and 129 g of Ce(NO3)3·6H2O, stir for 20 min to mix evenly, then transfer to a hydrothermal reactor, react at 220 ° C for 18 h, dry at 80 ° C to remove moisture, and then calcine at 700 ° C in a muffle furnace for 3 hours to obtain nano-gadolinium oxide-loaded lanthanum-cerium spherical particle material, recorded as LaCe@GdNPs-1.

[0049] 3) Preparation of glaze

[0050] Weigh the following raw materials of pearlescent material by weight: 49.59 parts by weight of quartz (SiO2), 0.98 parts by weight of copper oxide (CuO), 0.10 parts by weight of barium carbonate (BaCO3), 29.65 parts by weight of manganese oxide (MnO2), 0.10 parts by weight of magnesium oxide (MgO), 0.20 parts by weight of sodium carbonate (Na2CO3), 2.47 parts by weight of ferrosoferric oxide (Fe3O4) and 6.92 parts by weight of cobalt oxide (Co3O4);

[0051] Weigh the glaze raw materials by weight: 92.1 parts by weight of dolomite and 7.9 parts by weight of cobalt oxide (CoO);

[0052] The pearlescent material, colored glaze and LaCe@GdNPs-1 material were mixed in a mass ratio of 6:2:2 to prepare the rare earth functional glaze.

[0053] Example 3

[0054] A rare earth functional glaze for ceramics is prepared by the following method:

[0055] 1) Preparation of gadolinium oxide precursor

[0056] Weigh 100 g of GdCl3 and add it to 100 mL of ethyl silicate, then add 30 mL of deionized water and 30 mL of DMF, and after fully dissolving using magnetic stirring, add 9 mL of triethylamine, and continue stirring at 100 ° C for 6 hours to obtain a mixed suspension solution; then obtain the precipitate by centrifugation at 11000 rpm / 15 min, and freeze-dry the collected precipitate to obtain a gadolinium oxide precursor for use.

[0057] 2) Preparation of LaCe@GdNPs materials

[0058] Weigh 70.68 g of the intermediate gadolinium oxide precursor prepared in step 1), add 100 mL of deionized water, then add 43 g of La(NO3)3·6H2O and 215 g of Ce(NO3)3·6H2O, stir for 20 min to mix evenly, then transfer to a hydrothermal reactor, react at 220°C for 18 h, dry at 80°C to remove moisture, and then calcine at 700°C in a muffle furnace for 3 hours to obtain nano-gadolinium oxide-loaded lanthanum-cerium spherical particle material, recorded as LaCe@GdNPs-2.

[0059] 3) Preparation of glaze

[0060] Weigh the following raw materials of pearlescent material by weight: 49.59 parts by weight of quartz (SiO2), 0.98 parts by weight of copper oxide (CuO), 0.10 parts by weight of barium carbonate (BaCO3), 29.65 parts by weight of manganese oxide (MnO2), 0.10 parts by weight of magnesium oxide (MgO), 0.20 parts by weight of sodium carbonate (Na2CO3), 2.47 parts by weight of ferrosoferric oxide (Fe3O4) and 6.92 parts by weight of cobalt oxide (Co3O4);

[0061] Weigh the glaze raw materials by weight: 92.1 parts by weight of dolomite and 7.9 parts by weight of cobalt oxide (CoO);

[0062] The pearlescent material, colored glaze and LaCe@GdNPs material were mixed in a mass ratio of 6:3:1 to prepare the rare earth functional glaze.

[0063] Comparative Example 1

[0064] Weigh 43 g of Ce(NO3)3·6H2O and 43 g of La(NO3)3·6H2O, then add 100 mL of deionized water and 100 mL of ethanol, use magnetic stirring to fully dissolve, then add 5.2 g of GdCl3, and then add 90 mL of 45% NaOH solution, continue stirring at room temperature for 6 hours to obtain a mixed suspension solution.

[0065] The difference from the above-mentioned Example 1 is that this process does not have a hydrothermal synthesis process, and does not need to add ethyl silicate. The water is directly removed by drying at 80°C, and then the material is calcined at 700°C in a muffle furnace for 3 hours to obtain the gadolinium oxide-loaded lanthanum cerium LaCe@Gd material.

[0066] Comparative Example 2

[0067] The difference from the above-mentioned Example 1 is that only Ce(NO3)3·6H2O is added in step 2), which is recorded as Ce@GdNPs.

[0068] Comparative Example 3

[0069] The difference from the above-mentioned Example 1 is that in step 2), only La(NO3)3·6H2O is added, which is denoted as La@GdNPs.

[0070] Comparative Example 4

[0071] The difference from the above-mentioned Example 1 is that 86 g La(NO3)3·6H2O and 43 g Ce(NO3)3·6H2O are added in step 2), which is recorded as LaCe@GdNPs-3.

[0072] Comparative Example 5

[0073] The difference from the above-mentioned Example 1 is that in step 2), 9.73 g of the intermediate gadolinium oxide precursor prepared in step 1) is used, which is denoted as LaCe@GdNPs-4.

[0074] Comparative Example 6

[0075] The difference from the above-mentioned Example 1 is that cerium nitrate is replaced by cerium oxide, which is denoted as LaCe@GdNPs-5.

[0076] Comparative Example 7

[0077] The difference from the above-mentioned Example 1 is that lanthanum nitrate is replaced by lanthanum oxide, which is denoted as LaCe@GdNPs-6.

[0078] Comparative Example 8

[0079] The difference from the above-mentioned Example 1 is that gadolinium chloride is replaced by gadolinium nitrate, which is denoted as LaCe@GdNPs-7.

[0080] Comparative Example 9

[0081] The difference from the above-mentioned Example 1 is that the ratio of the pearlescent material, the colored glaze and the LaCe@GdNPs material is 3:3:4, and the obtained glaze is recorded as LaCe@GdNPs-B.

[0082] Antibacterial test

[0083] 1. Preparation of culture medium for Porphyromonas gingivalis

[0084] TSA medium is made up of 15.0 g of tryptone (tryptic digest of casein), 5.0 g of soy peptone (papain digest of soy flour), 5.0 g of sodium chloride, 15.0 g of agar, 5% defibrinated sheep blood, and 1 L of distilled water, with a pH range of 7.3 ± 0.2. The above solution is transferred to an autoclave and heated at 121 °C for 15 min.

[0085] 2. Cultivation of Porphyromonas gingivalis

[0086] A single colony of Porphyromonas gingivalis was inoculated into a blood plate medium (TSA + 5% defibrinated sheep blood) and cultured in an anaerobic environment of 80% N2-10% CO2-10% H2 for 72-96 h to obtain a suspension of Porphyromonas gingivalis with an optical density of 600 nm (OD 600 ) is used to evaluate the growth of Porphyromonas gingivalis. In the present invention, OD 600 =0.4-0.6.

[0087] 3. Preparation of LB medium

[0088] Liquid LB medium: Add 10 g NaCl, 10 g peptone and 5 g yeast extract to 1 L pure water, stir well and divide into 4 conical flasks, sterilize in a high pressure steam sterilizer at 121 °C for 25 min and set aside.

[0089] Solid LB medium: add 10 g NaCl, 10 g peptone, 5 g yeast extract and 15 g agar powder to 1 L pure water, sterilize in a high pressure steam sterilizer at 121 °C for 25 min, then pour into a disposable culture dish while hot, wait for cooling and solidification, seal with sealing film and place in a 4 °C refrigerator for later use.

[0090] 4. Cultivation of Escherichia coli

[0091] Inoculate a single colony of E. coli into a blood plate medium and culture it in a 37°C constant temperature incubator for 18-24 h to obtain a suspension of E. coli with an optical density at 600 nm (OD 600 ) is used to evaluate the growth of Escherichia coli. In the present invention, OD 600 =0.4-0.6.

[0092] 5. Glaze concentration experiment

[0093] The glazes of different concentrations (0, 10, 50, 100 mg / L) obtained in Example 1 were respectively mixed with the suspension of Porphyromonas gingivalis (OD600 = 0.2) were mixed and incubated at 37°C for 3 h. Then, 0.2 mL of the diluted bacterial suspension was spread on blood agar plates and incubated at 37°C for 18 h. The number of bacterial colonies was determined by the standard plate counting method, and the inhibition rate was calculated.

[0094] from Figure 1 It is clearly observed that: in the presence of 50 mg / L of glaze, the antibacterial rate of Porphyromonas gingivalis is more than 90%, specifically 91.38%; when it is greater than 50 mg / L, such as 100 mg / L, the antibacterial rate is 100%, so the concentration of the glaze can be used at 50-100 mg / L. The above plates were transferred to the fume hood for antibacterial timeliness evaluation. After the plate was placed for 3 months, only the plaque area of ​​the original surviving bacteria expanded, and no bacteria grew further, which shows that the antibacterial performance of the material has a long timeliness.

[0095] 6. Plate culture antibacterial experiment

[0096] 50 mg / L of the glaze prepared in each example and each comparative example was mixed with a suspension of Porphyromonas gingivalis (OD 600 =0.2) were mixed, incubated at 37℃ for 3 h, and then 0.2 mL of the diluted bacterial suspension was spread on the blood plate medium, incubated at 37℃ for 18 h, and the number of bacterial colonies was determined by the standard plate counting method, and then the inhibition rate was calculated. A blank control group was set at the same time.

[0097] Result analysis:

[0098] 1. If Figure 2 As shown, the glazes added with rare earth functional materials in Examples 1-3 all have good antibacterial effects on Porphyromonas gingivalis, with an antibacterial rate of more than 90%. Among them, the strongest effect is the glaze containing LaCe@GdNPs material prepared in Example 1, which can achieve an antibacterial rate of 100% on Porphyromonas gingivalis.

[0099] 2. By comparing Comparative Example 1, it can be seen that the LaCe@GdNPs material synthesized by hydrothermal synthesis has a better antibacterial effect, because the hydrothermal synthesis method can control the synthesis process of the material at the molecular level, and the prepared material has a smaller scale and a higher specific surface area, which means that the contact area between the material and the bacteria is larger and the antibacterial effect is better. By comparing Comparative Examples 2-8, it can be seen that the type, proportion, and type of raw materials used to prepare the LaCe@GdNPs material will affect the final antibacterial properties of the glaze. Only the glaze prepared according to the scheme given in this application has the best antibacterial rate against Porphyromonas gingivalis. By Comparative Example 9, it can be seen that the content of LaCe@GdNPs material in the glaze needs to be controlled to ensure the antibacterial rate effect of Porphyromonas gingivalis.

[0100] 7. Specificity of antibacterial activity

[0101] 50 mg / L of the glaze obtained in Example 1-3 was mixed with a suspension of Porphyromonas gingivalis and a suspension of Escherichia coli (OD 600 = 0.2) were mixed and incubated at 37°C for 3 h. Then, 0.2 mL of the diluted bacterial suspension was spread on blood agar plate and LB medium respectively and incubated at 37°C for 18 h. The number of bacterial colonies was determined by the standard plate count method, and the inhibition rate was calculated.

[0102] from Figure 3 It can be seen that the glaze also has a certain degree of antibacterial effect on Escherichia coli, but the antibacterial rate is 63.0%-74.4%. The antibacterial effect on Porphyromonas gingivalis is more significant, and the antibacterial rate can reach more than 90%, indicating that the glaze is more suitable for killing Porphyromonas gingivalis.

[0103] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A rare earth functional glaze for ceramics, characterized in that: The glaze comprises pearlescent material, color glaze and LaCe@GdNPs material in a mass ratio of 6:(2-3):(1-2); wherein the LaCe@GdNPs material is prepared by using Ce(NO3)3, La(NO3)3 and GdCl3 as raw materials; The preparation method of LaCe@GdNPs material is as follows: GdCl3 is used as raw material, the surface is coated with ethyl silicate to form spherical particles, and then the nano-gadolinium-loaded lanthanum cerium spherical particles LaCe@GdNPs material is prepared by hydrothermal synthesis with Ce(NO3)3·6H2O and La(NO3)3·6H2O; The molar ratio of La(NO3)3·6H2O to Ce(NO3)3·6H2O is 1:(1-5); La 3+ and Ce 3+ With Gd 3+ The molar ratio is 3:(0.5-2).

2. The rare earth functional glaze for ceramics according to claim 1, characterized in that: The pearlescent material includes, by weight: 40-50 parts of quartz, 0.5-1 parts of copper oxide, 0.1-0.5 parts of barium carbonate, 20-30 parts of manganese oxide, 0.1-0.5 parts of magnesium oxide, 0.1-0.5 parts of sodium carbonate, 1-3 parts of ferrosoferric oxide and 5-7 parts of cobalt oxide.

3. The rare earth functional glaze for ceramics according to claim 1, characterized in that: The colored glaze comprises, by weight: 80-95 parts of dolomite and 5-20 parts of cobalt oxide.

4. A method for preparing a rare earth functional glaze for ceramics according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: 1) Preparation of LaCe@GdNPs materials GdCl3 was used as raw material, and the surface was coated with ethyl silicate to form spherical particles, and then the nano-gadolinium-loaded lanthanum-cerium spherical particles LaCe@GdNPs were prepared by hydrothermal synthesis with Ce(NO3)3·6H2O and La(NO3)3·6H2O. 2) Directly mix the pearlescent material, color glaze and LaCe@GdNPs material according to the proportion, stir evenly and it is ready for use.

5. An application of the rare earth functional glaze for ceramics as claimed in any one of claims 1 to 3 in oral antibacterial treatment, characterized in that: The glaze is used to disinfect stubborn Porphyromonas gingivalis in the oral cavity.

6. The use of the rare earth functional glaze for ceramics according to claim 5, characterized in that: The usage concentration of the glaze is 50mg / L-100mg / L.

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