A novel glove box based on a slide gate valve for sample introduction and transfer chamber and its usage method

Abstract

This invention relates to a novel glove box based on a slide gate valve-connected sample inlet and transfer chamber, and its usage method. The glove box has a connecting interface on its side wall, through which an external slide gate valve-type glove box transition chamber is installed, connecting the inside and outside of the glove box. The output end of the external slide gate valve-type glove box transition chamber is equipped with an external slide gate valve. The external slide gate valve-type glove box transition chamber has a sealed working state and an open sample loading state for transferring the sample to be tested. A movable sample transfer assembly is located inside the external slide gate valve-type glove box transition chamber. This invention provides a continuous sampling gas protective atmosphere and facilitates convenient and simple sampling during the injection process.

Description

Technical Field

[0001] This invention relates to the field of vacuum glove box technology, and more particularly to a novel glove box based on a sample inlet valve and a transfer chamber, and its method of use. Background Technology

[0002] A vacuum glove box is a laboratory device that fills its interior with high-purity inert gas and circulates it to filter out any active substances. By controlling the conditions inside the vacuum glove box, an ideal microenvironment can be created. In the biological and pharmaceutical industries, certain specific conditions are required for operations and experiments, necessitating specific environments, such as nitrogen-filled glove boxes.

[0003] CN106541134B discloses a glovebox-type laser selective melting device based on a vacuum oxygen-free environment. This device provides an anhydrous and oxygen-free glovebox operating environment. The left side of the vacuum glovebox is connected to a vacuum transition chamber via an isolation and protective locking device. The left side of the vacuum transition chamber is equipped with a door clamping device. A protective gas inlet is located on the lower left side of the vacuum glovebox. The right side of the vacuum glovebox is connected to a vacuum pump group via a vacuum pipeline. CN206855492U discloses a vacuum glovebox turnover chamber, including an outer door, a turnover chamber, an inner door, and a turnover chamber hinge. The outer and inner doors are rotatably connected to both ends of the turnover chamber via the turnover chamber hinge. CN216731895U discloses a vacuum glovebox for rapid adjustment. This device provides a rapidly adjustable vacuum glovebox, including a glovebox and a transition chamber connected in sequence. The glovebox has a first through-hole in the middle of one end and a second through-hole communicating with the transition chamber at the lower part of the other end. An arc-shaped cover is provided on the outer side of the first through-hole. Its advantage lies in the ability to quickly adjust the transition chamber through modification. A novel multi-purpose transition chamber for a vacuum glove box, disclosed in publication number CN217020473U, provides a transition chamber structure with inner doors on both sides. The key feature of this patent is the presence of two doors inside the transition chamber, allowing for bidirectional sample introduction.

[0004] As can be seen from the existing technical records, as a precision device, a transition chamber is essential for a glove box. However, the existing transition chambers have a simple structure and cannot transfer special samples. In actual use, their installation structure has insufficient sealing, which affects the experimental accuracy inside the glove box. Summary of the Invention

[0005] In response to the aforementioned technical problems, a novel glove box based on a slide gate valve for sample introduction and transfer chamber, and its usage method are provided.

[0006] The technical means employed in this invention are as follows:

[0007] A novel glove box based on a slide gate valve-connected transfer chamber is disclosed. The glove box has a connecting interface on its side wall, and an external slide gate valve-type glove box transition chamber connecting the inside and outside of the glove box is installed at the connecting interface. The output end of the external slide gate valve-type glove box transition chamber is provided with an external slide gate valve. The external slide gate valve-type glove box transition chamber has a sealed working state and an open sample loading state for transferring the test sample. A movable test sample transfer assembly is provided inside the external slide gate valve-type glove box transition chamber.

[0008] Furthermore, the externally mounted slide gate valve type glove box transition chamber includes a flange and a glove box transition chamber shell. The glove box transition chamber shell is installed to the glove box side wall via the flange. Each end of the glove box transition chamber shell is rotatably connected to a sealing panel. The atmospheric side sealing panel of the transition chamber away from the glove box is provided with a flange interface for connecting the slide gate valve. It also includes a transition chamber door opening limiter, which is installed on the outside of the transition chamber to limit the opening angle of the atmospheric side sealing panel of the transition chamber. The glove box transition chamber shell is provided with an internal sliding support for adjusting the position of the sample transfer assembly relative to the inside of the glove box. The glove box transition chamber shell is also equipped with a transition chamber door closing sealing lock, which cooperates with the sealing panel to complete the sealing state of the sealing panel in the working state.

[0009] Furthermore, the sample transfer assembly is provided with an outer handle on the side facing the glove box in the direction of travel, and an array probe assembly clamping device is provided on the other side of the sample transfer assembly.

[0010] Furthermore, a pressure gauge for the transition chamber is installed on the outer shell of the glove box transition chamber, and a gas connecting pipe is connected to the outer shell of the glove box transition chamber. The other end of the gas connecting pipe is connected to a three-way pipe, and an angle valve is installed on the input section of the three-way pipe. The first input section of the three-way pipe is connected to a protective gas source, and the other input section of the three-way pipe is connected to a negative pressure vacuum device.

[0011] Furthermore, the slide gate valve can dock with the transfer sealing slide gate valve of the micro-sample transfer chamber, thereby completing the transfer of the sample to be tested between the glove box, the external slide gate valve type glove box transition chamber and the micro-sample transfer chamber.

[0012] Further, the array probe assembly includes a lower support base for the array probe, an upper fixing cover plate for the array probe, and array probe fixing screws. The upper surface of the lower support base has several grooves evenly spaced along its length direction, parallel to its width direction. These grooves form a linear array with equal spacing. The grooves of the lower support base are either complete grooves capable of accommodating sampling and ionization detection probes, or grooves that fit the lower support base are formed on the bottom surface of the upper fixing cover plate. The grooves on the bottom surface of the upper fixing cover plate and the grooves of the lower support base together form a complete groove capable of accommodating sampling and ionization detection probes. A screw hole is provided on the lower support base of the array probe, which is a preset distance away from the groove. A screw hole matching the screw hole of the lower support base of the array probe is also provided on the upper fixing cover plate of the array probe. The upper fixing cover plate and the lower support base of the array probe are detachably connected by the array probe fixing screw. The bottom of the lower support base of the array probe assembly is provided with a protruding step structure. Based on the step structure, the array probe assembly is introduced into the sample transfer assembly. The array probe assembly clamping device specifically includes a transfer assembly spring-type pressing plate provided at one end of the sample transfer assembly. The array probe assembly is clamped by the transfer assembly spring-type pressing plate.

[0013] Furthermore, the micro-sample transfer chamber includes an array probe storage chamber, a transfer sealing valve, an array probe assembly, a self-locking rotary sampling head, and a self-locking rotary sampling head position adjustment mechanism. The array probe storage chamber is filled with a preset protective gas. The transfer sealing valve is installed at one end of the array probe storage chamber. The self-locking rotary sampling head position adjustment mechanism is installed at the other end of the array probe storage chamber. The self-locking rotary sampling head is located inside the array probe storage chamber and its output end relative to the transfer sealing valve can be adjusted by the self-locking rotary sampling head position adjustment mechanism. The output end of the self-locking rotary sampling head can be detachably connected to the array probe assembly. After the valve and the transfer sealing valve are connected, the array probe assembly is in a protective gas atmosphere throughout the process.

[0014] Furthermore, the self-locking rotary sampling head position adjustment mechanism is a multi-layer nested structure, including a self-locking rotary sampling head storage cavity, a coarse position adjustment device, and a linear telescopic precision adjustment component. The end of the array probe storage cavity is connected to one end of the self-locking rotary sampling head storage cavity. The linear telescopic precision adjustment component is installed at the end of the self-locking rotary sampling head storage cavity near the array probe storage cavity. The self-locking rotary sampling head is connected to the output end of the magnetic internal connecting rod. The self-locking rotary sampling head storage cavity is specifically a magnetic support outer bracket. The coarse position adjustment device includes a magnetic external drive component, which is sleeved on the outer wall of the magnetic support outer bracket. The magnetic external drive component can slide linearly on the magnetic support outer bracket, synchronously driving the linear sliding of the internal magnetic rod.

[0015] This invention also discloses a method for using the novel glove box based on the above-mentioned sample inlet connection and transfer chamber using a slide gate valve, comprising the following steps:

[0016] Step 1: Open the sealing panel. Before opening, ensure that the transition chamber of the external insert valve glove box is at normal pressure. Place the sample transfer assembly to be tested into the transition chamber of the external insert valve glove box.

[0017] Step 2: Cover the atmospheric side sealing panel of the external slide valve type glove box transition chamber and close the sealing locking device. During this process, the front slide valve is in a closed and sealed state, and the sealing panel inside the glove box is also in a closed state; after the glove box transition chamber shell is evacuated, a protective gas atmosphere is provided.

[0018] Step 3: Based on the experimental requirements, complete the installation of the self-locking rotary sampling head and array probe assembly, and form a protective gas atmosphere inside the micro-sample transfer chamber;

[0019] Step 4: Connect the transfer sealing gate valve of the micro-sample transfer chamber to the gate valve of the gate valve type glove box.

[0020] Step 5: Push the array probe assembly located at the end of the self-locking rotary sampling head out of the array probe storage cavity by using the coarse adjustment and / or fine adjustment functions of the self-locking rotary sampling head position adjustment mechanism.

[0021] Step 6: Open the transfer sealing valve of the micro-sample transfer chamber and the gate valve of the gate valve type glove box to transfer the array probe assembly into the glove box.

[0022] Furthermore, the internal magnetic connecting rod has three key locations.

[0023] One is the initial position of the magnetic rod, at which point an array sampling probe is installed. The array sampling probe is stored in the cavity, and the slide valve can be closed or opened without interference between the slide valve and the array sampling probe.

[0024] Secondly, by manually adjusting the external magnetic drive assembly, the internal magnetic connecting rod is transferred to the initial position of the precision adjustment component. At this time, the sample is detached from the array probe storage cavity and located outside the insert valve.

[0025] Thirdly, fine adjustment begins. The rotation of the linear telescopic top rotating drive component drives the entire precision adjustment component to move downwards or upwards. When it moves downwards to the bottom of the fine adjustment component, it is at the longest position that the array sampling needle can extend.

[0026] Compared with existing technologies, this invention has the following advantages: The present invention places the sample into the transfer chamber, performs gas replacement in the transition chamber, and then places the sample in a vacuum glove box for weighing and loading. For some special samples, a water- and oxygen-free environment must still be maintained after sampling from the glove box. Therefore, during use, the vacuum glove box needs to be used in conjunction with the transfer chamber, and a gate valve is used to connect the transfer chamber. Simultaneously, the transition chamber is modified to make sampling more convenient and simpler during the sample introduction process. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0028] Figure 1 This is a schematic diagram of the overall structure of the novel glove box based on the sample inlet and transfer chamber of the present invention.

[0029] Figure 2 This is a schematic diagram of the external insert valve inlet glove box structure of the present invention.

[0030] Figure 3 The door of the transition chamber of this invention is opened to insert the sample transfer assembly to be tested.

[0031] Figure 4 This is a schematic diagram showing the sample transfer assembly of the present invention fully placed into the transition chamber.

[0032] Figure 5 The atmospheric side sealing panel of the transition chamber is closed for this invention.

[0033] Figure 6 This is a schematic diagram illustrating the bottom assembly method of the sample transfer component and the array sampling probe component of the present invention.

[0034] Figure 7This is an isometric view of the cooperation between the sample transfer assembly and the array probe assembly of the present invention.

[0035] Figure 8 This is an exploded schematic diagram of the sample adapter assembly of the present invention.

[0036] Figure 9 This is a schematic diagram showing the separation of the micro-sample transfer chamber and the external insert valve-type transition chamber of the present invention.

[0037] Figure 10 This is a schematic diagram showing the connection state between the micro-sample transfer chamber and the sample introduction transition chamber of the slide valve in this invention.

[0038] Figure 11 This is a schematic diagram showing the opening of the external insert valve of the glove box transition chamber of the present invention, allowing the array probe assembly to be inserted into the sample transfer assembly.

[0039] Figure 12 This diagram illustrates the opening of the inner sealing panel of the glove box in the transition chamber of the present invention, in preparation for placing the sample transfer assembly to be tested into the glove box.

[0040] Figure 13 This is a schematic diagram showing the sealing panel inside the glove box of the transition chamber closed after the sample transfer assembly of the present invention is placed into the glove box.

[0041] Figure 14 This is a schematic diagram of the array probe assembly placed on the right side being removed from the sample transfer assembly of the present invention.

[0042] Figure 15 This is a schematic diagram illustrating the process of removing the upper cover plate of the array probe assembly inside the glove box and taking out the probes, as per the present invention.

[0043] Figure 16 This is a schematic diagram illustrating how the array probe assembly is placed back into the sample transfer assembly, preparing to be placed back into the glove box transition chamber together.

[0044] Figure 17 This is a schematic diagram of the array probe assembly and the sample transfer assembly of the present invention being placed back into the glove box transition chamber.

[0045] Figure 18 This is a schematic diagram of the sealing panel inside the glove box of the transition chamber according to the present invention.

[0046] Figure 19 This is a schematic diagram illustrating how the array probe assembly is removed from the glove box transition chamber using a micro-sample transfer cavity, according to the present invention.

[0047] Figure 20 This is a schematic diagram illustrating the separation of the micro-sample transfer chamber containing the array probe assembly from the externally mounted plate valve glove box transition chamber according to the present invention.

[0048] Figure 21This is a schematic diagram of the glove box transition compartment of the present invention returning to its initial mode.

[0049] Figure 22 This is a schematic diagram of the internal structure of the micro-sample transfer chamber of the present invention.

[0050] In the figure: 001: External gate valve type glove box transition chamber; 002: Internal sliding support component of the glove box transition chamber; 003: Sample transfer assembly; 004: Outer shell of the glove box transition chamber; 005: Gas connection pipe; 006: Atmospheric side sealing panel of the transition chamber; 007: Micro-sample transfer chamber; 008: Door opening limit component of the transition chamber; 009: Door closing sealing and locking component of the transition chamber; 010: External gate valve of the glove box transition chamber; 012: Negative pressure pump; 013: Pressure gauge of the transition chamber; 014: Inner sealing panel of the transition chamber glove box; 101: Array probe assembly; 1 03: Linear telescopic precision adjustment component; 104: Magnetic support connecting rod; 105: Magnetic external drive component; 107: Array probe storage cavity; 108: Transfer cavity sealing insert valve; 109: Self-locking rotary sampling head and connecting rod; 201: Array probe fixing screw; 202: Array probe upper end fixing cover plate; 203: Array probe lower end support base; 204: Sampling and ionization detection probe; 301: Outer handle of adapter component; 302: Adapter component support; 303: Adapter component spring-type pressing plate; 304: Adapter component pressing plate fixing screw. Detailed Implementation

[0051] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0052] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the present invention or its application or use. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0053] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of exemplary embodiments according to the invention. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0054] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps described in these embodiments do not limit the scope of the invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following figures denote similar items; therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0055] In the description of this invention, it should be understood that the orientation or positional relationship indicated by directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" is generally based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing this invention and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this invention. The directional terms "inner" and "outer" refer to the inner and outer contours relative to the outline of each component itself.

[0056] For ease of description, spatial relative terms such as "above," "over," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation besides the orientation of the device as described in the figures. For example, if the device in the figures is inverted, a device described as "above" or "above" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0057] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore should not be construed as limiting the scope of protection of this invention.

[0058] like Figures 1-22 As shown in the figure, this invention discloses a novel glove box based on a slide gate valve for sample introduction and transfer chamber connection. The glove box has a connecting interface on its side wall, and an external slide gate valve-type glove box transition chamber 001 connecting the inside and outside of the glove box is installed at the connecting interface. An external slide gate valve 010 is provided at the output end of the external slide gate valve-type glove box transition chamber 001. The external slide gate valve-type glove box transition chamber 001 has a sealed working state and an open sample loading state for sample transfer. A movable sample transfer assembly 003 is provided inside the external slide gate valve-type glove box transition chamber 001. Based on this external slide gate valve 010, seamless docking of the sample in the protective gas atmosphere between the sample chamber, transition chamber, and glove box is achieved.

[0059] Furthermore, the externally mounted slide gate valve type glove box transition chamber 001 includes a flange and a glove box transition chamber outer shell 004. The glove box transition chamber outer shell 004 is installed to the glove box side wall via the flange. Sealing panels are rotatably connected to the ends of the glove box transition chamber outer shell 004, with the inner sealing panel 014 of the transition chamber located inside the glove box. A flange interface for connecting the slide gate valve is provided on the atmospheric side sealing panel 006 of the transition chamber, which is located away from the glove box. It also includes a transition chamber opening limiter 008, which is installed on the outside of the transition chamber to limit the opening angle of the atmospheric side sealing panel 006. An internal sliding support 002 is provided inside the glove box transition chamber outer shell 004 for adjusting the position of the sample transfer assembly 003 relative to the inside of the glove box. A transition chamber closing sealing lock 009 is also installed on the glove box transition chamber outer shell, which cooperates with the sealing panel to achieve a sealing state of the sealing panel during operation.

[0060] The glove box provided in this embodiment has two opening methods. One is the same as a traditional glove box, where the door is opened and closed normally via the sealing panel. In this case, the external glove box transition chamber external valve 010 is in a closed and locked state. The other state is when a matching external glove box transition chamber valve 010 is connected to the outside of the cavity, allowing the glove box to work with the micro-sample transfer chamber to facilitate convenient sample transfer in an inert gas environment.

[0061] Furthermore, the sample transfer assembly 003 is provided with an outer handle 301 on the side facing the glove box in the direction of travel, and an array probe assembly clamping device is provided on the other side of the sample transfer assembly 003.

[0062] Furthermore, a pressure gauge 013 is installed on the outer shell 004 of the glove box transition chamber. A gas connection pipe 005 is connected to the outer shell 004 of the glove box transition chamber, and a tee pipe is connected to the other end of the gas connection pipe 005. An angle valve is installed on the input section of the tee pipe. The first input section of the tee pipe is connected to a protective gas source, and the other input section of the tee pipe is connected to a negative pressure vacuum pump 012. One side is a vacuum negative pressure evacuation position, which uses the negative pressure vacuum pump to achieve negative pressure evacuation of the cavity. Depending on the performance of the vacuum pump, a range of 1-500 Pa is acceptable. When the tee connecting the gas line is placed in the inert gas charging position, the inert gas charging operation is performed.

[0063] Furthermore, the external gate valve 010 of the glove box transition chamber can dock with the transfer sealing gate valve 108 of the micro sample transfer chamber, thereby completing the transfer of the sample to be tested between the glove box, the external gate valve type glove box transition chamber 001 and the micro sample transfer chamber 007.

[0064] Further, the array probe assembly 011 includes a lower support base 203 for the array probe, an upper fixing cover 202 for the array probe, and array probe fixing screws 201. The upper surface of the lower support base 203 has several grooves evenly spaced along its length direction and parallel to its width direction, forming a linear array with equal spacing. The grooves of the lower support base 203 are either complete grooves capable of accommodating the sampling and ionization detection probes 204, or grooves that mate with the lower support base 203 are formed on the bottom surface of the upper fixing cover 202. The grooves on the bottom surface of the upper fixing cover 202 and the grooves of the lower support base 203 together form a complete groove capable of accommodating the sampling and ionization detection probes 204. The array is spaced apart from the grooves by a predetermined distance. The lower support base 203 of the array probe has a screw hole, and the upper fixing cover plate 202 of the array probe also has a screw hole matching the screw hole of the lower support base 203 of the array probe. The upper fixing cover plate 202 and the lower support base 203 of the array probe are detachably connected by the array probe fixing screw 201. The bottom of the lower support base 203 of the array probe assembly has a protruding step structure. Based on this step structure, the array probe assembly 011 is introduced into the sample transfer assembly 003. The sample transfer assembly 003 includes the main body of the transfer assembly support 302. The array probe assembly clamping device specifically includes a transfer assembly spring-type pressing plate 303 provided at one end of the main body of the transfer assembly support. The array probe assembly 011 is clamped by the transfer assembly spring-type pressing plate 303.

[0065] In this embodiment, the spring-loaded clamping plate 303 is used to fix the array probe assembly 011. The clamping plate is connected by adapter assembly clamping plate fixing screws 304 that fit on both sides. The lifting handle 301 allows the entire sample adapter assembly 003 to be moved.

[0066] The spring-loaded clamping plate 303 has two outward-facing corners, which facilitate the insertion of the array probe assembly from the side. Insertion is performed from one side along the direction of travel. The stress of the spring-loaded clamping plate 303 holds the adapter assembly under its pressure, securing the array probe assembly and preventing it from falling off during sampling using the handle 301. After the array probe is placed into the adapter, the adapter can be used to move the probe assembly from the chamber to the glove box chamber. The adapter and the slide rail in the transition chamber have a good fit, allowing the sliding assembly to slide within the transition chamber.

[0067] Furthermore, the micro-sample transfer chamber 007 includes an array probe storage chamber 107, a transfer chamber sealing valve 108, an array probe assembly 011, a self-locking rotary sampling head 109, and a self-locking rotary sampling head position adjustment mechanism. The array probe storage chamber 107 is filled with a preset protective gas. The transfer chamber sealing valve 108 is installed at the end of the array probe storage chamber 107. The self-locking rotary sampling head position adjustment mechanism is installed at the other end of the array probe storage chamber 107. The self-locking rotary sampling head 109 is disposed inside the array probe storage chamber 107 and its output end relative to the transfer sealing valve can be adjusted by the self-locking rotary sampling head 109 position adjustment mechanism. The output end of the self-locking rotary sampling head 109 can be detachably connected to the array probe assembly 011. After the valve and the transfer sealing valve are connected, the array probe assembly 011 is in a protective gas atmosphere throughout the process.

[0068] Furthermore, the self-locking rotary sampling head position adjustment mechanism is a multi-layer nested structure, including a self-locking rotary sampling head storage cavity, a coarse position adjustment device, and a linear telescopic precision adjustment component 103. The end of the array probe storage cavity 107 is connected to one end of the self-locking rotary sampling head storage cavity. The linear telescopic precision adjustment component 103 is installed at one end of the self-locking rotary sampling head storage cavity near the array probe storage cavity 107. The self-locking rotary sampling head 109 is connected to the output end of the magnetic support connecting rod 104. The storage cavity of the self-locking rotary sampling head 109 is specifically a magnetic support outer bracket. The coarse position adjustment device includes a magnetic external drive component 105, which is sleeved on the outer wall of the magnetic support outer bracket. The magnetic external drive component 105 can slide linearly on the magnetic support outer bracket, synchronously driving the linear sliding of the internal magnetic rod.

[0069] Specifically, the method for moving the main body of the invention is as follows: The array probe assembly 011 in the micro-sample transfer chamber 007 is moved from the micro-sample transfer chamber 007 to the test sample transfer assembly 003, secured by the transfer chamber sealing valve 108 and the external valve 010 of the glove box transition chamber. The test sample transfer assembly 003 is then opened through the inner sealing panel 014 of the glove box, removed, and placed inside the glove box. Through the test sample transfer assembly 003, the array probe assembly 011 can be retrieved into the glove box, allowing operation on the probes by injecting a certain amount of test sample into them. The sample addition method can be selected by adding the sample to each probe individually, or by holding the entire array probe assembly and sequentially adding the sample using a sample injector. After the sample addition is completed, the array probes are returned to the micro-sample transfer chamber in reverse order. After the transfer is complete, the micro-sample transfer chamber is removed from the external valve-type glove box transition chamber.

[0070] This invention also discloses a method for using the novel glove box based on the above-mentioned sample inlet connection and transfer chamber using a slide gate valve, comprising the following steps:

[0071] Step 1: Open the sealing panel. Before opening, ensure that the internal pressure of the external insert valve type glove box transition chamber 001 is normal. Place the sample transfer assembly 003 to be tested into the external insert valve type glove box transition chamber 001. At this time, use your hand to support the bottom and place it into the chamber, with the handle facing inward. After placing the transition chamber into the chamber and feeding it into the guide rail, place the entire transition chamber into the transition chamber. In order to close the chamber door, all protruding tips should also be placed into the transition chamber.

[0072] Step 2: Cover the atmospheric side sealing panel of the external slide gate valve type glove box transition chamber 001 and close the sealing locking device. During this process, the front slide gate valve is in a closed and sealed state, and the sealing panel inside the glove box is also in a closed state. At this time, the seals of both doors of the glove box transition chamber are in a closed state, and the glove box transition chamber outer shell 004 is evacuated and a protective gas atmosphere is provided. At this time, the interior of the transition chamber can be filled with nitrogen. Control the three-way valve to ensure that the cavity is replaced by nitrogen.

[0073] Step 3: Based on experimental requirements, complete the installation of the self-locking rotary sampling head 109 and the array probe assembly 011, close the transfer chamber sealing valve 108, and form a protective gas atmosphere inside the micro-sample transfer chamber 007, such as... Figure 9 As shown;

[0074] It should be noted that step 3 above can also be completed as a prerequisite for step 1, and there is no obvious order requirement.

[0075] Step 4: Push the array probe assembly 011 located at the end of the self-locking rotary sampling head 109 out of the array probe storage cavity 107 by using the coarse adjustment and / or fine adjustment functions of the position adjustment mechanism of the self-locking rotary sampling head 109.

[0076] Step 5: Connect the transfer sealing gate valve of the micro-sample transfer chamber 007 to the gate valve of the gate valve type glove box, such as... Figure 10 As shown; at this time, the air inside the trace sample transfer chamber mixes with the nitrogen in the transition chamber. Therefore, a vacuum pump is used in conjunction with nitrogen filling to fill all the gas in both chambers with high-concentration nitrogen. The pressure gauge reading is observed. The two chambers are at the same pressure and therefore at one atmosphere of nitrogen concentration.

[0077] Step 6: Open the transfer sealing valve of the micro sample transfer chamber 007 and the valve of the valve-type glove box to transfer the array probe assembly 011 into the glove box.

[0078] Specifically, such as Figure 11 As shown, the magnetic telescopic rod inside the micro-sample transfer chamber is used to insert the array probe into the sample slot on the sample connection assembly. Figure 12 , 13 As shown, using the glove box, the operator reaches into the glove box and opens the inner sealed chamber. Before opening, both chambers are under nitrogen protection. After opening the chamber door, the operator uses the handle to remove the entire transfer chamber assembly. The sample transfer assembly, along with the array sampling needle, is then placed into the glove box. After placing both components in the glove box, the inner sealed panel can be closed for easier operation. Two hands can then be used: one hand holds the transfer assembly in place, while the other hand slides the array probe assembly out using the right side. All these operations are performed using the two gloves of the glove box. During the array probe operation, the probe can be fixed to the upper and lower cover plates of the assembly for sample injection. The probe can also be removed by loosening the three screws on the upper cover plate. Then, each probe can be operated on. Different solvents or the same solvent can be added to each probe, and different concentrations can be used. The concentration of the added solution needs to be recorded. After loading each probe into the sample, the probes need to be placed back into the probe assembly one by one, and the screws need to be tightened. Then, insert the probes into the sample adapter assembly from the side for easy return later.

[0079] After sample loading, place the array probe back onto the transfer assembly and open the sealed panel inside the glove box. At this point, the glove box, the transition chamber, and even the micro-sample transfer chamber are all filled with inert protective gas. Therefore, the micro-samples loaded into the probe within the glove box are effectively isolated from air, preventing contamination from oxygen, moisture, etc. Using the handle on the outside of the adapter, insert the transfer sampling device into the end of the transition chamber, ensuring the array probe can be grasped by the self-locking sampling head. By adjusting the connecting rod of the micro-sample transfer chamber, slowly move the array probe into the array probe storage chamber. Simultaneously, close the gate valve of the glove box transition chamber and the transfer chamber. Now, both the glove box transition chamber and the micro-sample transfer chamber are filled with inert gas, ensuring sample protection throughout the entire transfer process.

[0080] Furthermore, the internal magnetic connecting rod has three key locations.

[0081] One is the initial position of the magnetic rod, at which time the array probe assembly 011 is installed in the micro sample transfer chamber 007, and the transfer chamber sealing valve 108 can be closed or opened. The transfer chamber sealing valve 108 does not interfere with the array probe assembly 011.

[0082] Secondly, by manually adjusting the external magnetic drive assembly 105, the internal magnetic connecting rod is transferred to the initial position of the precision adjustment component. At this time, the sample is detached from the array probe storage cavity 107 and located outside the transfer cavity sealing insert valve 108.

[0083] Thirdly, fine adjustment begins. The rotation of the linear telescopic top rotating drive component drives the entire precision adjustment component to move downwards or upwards. When it moves downwards to the bottom of the fine adjustment component, it is at the longest position that the array sampling needle can extend.

[0084] The above-mentioned sample loading and micro-sample transfer chamber are operated as follows:

[0085] The first step is as follows Figure 16 As shown, open the inner sealing panel of the transition chamber and place the sample transfer assembly containing the probe assembly into the transition chamber. During the placement process, be sure to place the protruding middle part of the transition chamber transfer assembly into the sliding support inside the glove box transition. At this state, the right side of the transition chamber is connected to the micro sample transfer chamber. The interior of the transition chamber is protected by inert gas, and both the micro sample transfer chamber and the two gate valves of the transition chamber are in the open state.

[0086] The second step is as follows: Figure 17 As shown, slide the sample transfer assembly to the position near the slide valve in the transition chamber of the cavity, and keep the transition chamber locked in place.

[0087] The third step is as follows: Figure 18 As shown, the inner sealing panel of the transition chamber glove box is closed, and the self-locking rotary sampling head in the micro-sample transfer chamber is locked to the protruding connecting hole on the right side of the array probe assembly.

[0088] Step 4 Figure 19 As shown, the array probe assembly is removed from the sample transfer assembly and placed inside the micro-sample transfer chamber by dragging the magnetic telescopic rod in the micro-sample transfer chamber. At this time, the gate valve of the glove box transition chamber is closed, as is the gate valve of the micro-sample transfer chamber. It can be seen that the transition chamber and the sample transfer chamber are still under an inert gas protective atmosphere.

[0089] Step 5 Figure 20 As shown, the microsample transfer chamber is disassembled from the glovebox transition chamber, separating the two components. The microsample transfer chamber, now filled with the sample, can be placed in other instruments or stored, with the liquid compound protected by an inert gas. The disassembled glovebox transition chamber returns to its initial state, containing the sample transfer assembly, with the gate valve closed and both doors closed.

[0090] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A novel glove box based on a sample transfer chamber connected by a slide gate valve, wherein the side wall of the glove box is provided with a connection interface, and the connection interface is equipped with an external slide gate valve type glove box transition chamber (001) connecting the inside and outside of the glove box. The output end of the external slide gate valve type glove box transition chamber (001) is provided with an external slide gate valve (010). The external slide gate valve type glove box transition chamber (001) has a sealed working state and an open sample loading state for transferring the sample to be tested. The interior of the external slide gate valve type glove box transition chamber (001) is provided with a movable sample transfer assembly (003). The external gate valve (010) of the glove box transition chamber can dock with the transfer sealing gate valve (108) of the micro sample transfer chamber, thereby completing the transfer of the sample to be tested between the glove box, the external gate valve type glove box transition chamber (001) and the micro sample transfer chamber (007). The micro-sample transfer chamber (007) includes an array probe storage chamber (107), a transfer chamber sealing valve (108), an array probe assembly (011), a self-locking rotary sampling head (109), and a self-locking rotary sampling head position adjustment mechanism. The array probe storage chamber (107) is filled with a preset protective gas. The transfer chamber sealing valve (108) is installed at one end of the array probe storage chamber (107), and the self-locking rotary sampling head position adjustment mechanism is installed at the other end of the array probe storage chamber (107). A rotating sampling head position adjustment mechanism is provided. The self-locking rotating sampling head (109) is located inside the array probe storage cavity (107) and its output end relative to the transfer sealing gate valve can be adjusted by the self-locking rotating sampling head (109) position adjustment mechanism. The output end of the self-locking rotating sampling head (109) can be detachably connected to the array probe assembly (011). After the gate valve and the transfer sealing gate valve are docked, the array probe assembly (011) is in a protective gas atmosphere throughout the process.

2. The novel glove box based on a slide gate valve for sample introduction and transfer chamber according to claim 1, characterized in that, The external slide gate valve type glove box transition chamber (001) includes a flange and a glove box transition chamber shell (004). The glove box transition chamber shell (004) is installed on the glove box side wall through the flange. The ends of the glove box transition chamber shell (004) are rotatably connected to sealing panels. The transition chamber atmospheric side sealing panel (006) away from the glove box is provided with a flange interface for connecting the slide gate valve. It also includes a transition chamber door opening limiter (008). The transition chamber door opening limiter (008) is installed on the outside of the transition chamber to limit the opening angle of the transition chamber atmospheric side sealing panel (006). The glove box transition chamber shell (004) is provided with a glove box transition internal sliding support (002) for adjusting the position of the sample transfer assembly (003) relative to the inside of the glove box. The glove box transition chamber shell is also equipped with a transition chamber door closing sealing lock (009). The transition chamber door closing sealing lock (009) cooperates with the sealing panel to complete the sealing state of the sealing panel in the working state.

3. The novel glove box based on a slide gate valve for sample introduction and transfer chamber according to claim 1, characterized in that, The sample transfer assembly (003) is provided with an outer handle (301) on the side facing the glove box in the direction of travel, and an array probe assembly clamping device is provided on the other side of the sample transfer assembly (003).

4. The novel glove box based on a slide gate valve for sample introduction and transfer chamber according to claim 2, characterized in that, A transition chamber pressure gauge (013) is installed on the outer shell (004) of the glove box transition chamber. A gas connection pipe (005) is connected to the outer shell (004) of the glove box transition chamber. A three-way pipe is connected to the other end of the gas connection pipe (005). An angle valve is installed on the input section of the three-way pipe. The first input section of the three-way pipe is connected to a protective gas source, and the other input section of the three-way pipe is connected to a negative pressure air pump (012).

5. The novel glove box based on a slide gate valve for sample introduction and transfer chamber according to claim 1, characterized in that, The array probe assembly (011) includes a lower support base (203) for the array probe, an upper fixing cover plate (202) for the array probe, and array probe fixing screws (201). The upper surface of the lower support base (203) has several grooves evenly spaced along its length direction and parallel to its width direction. These grooves form a linear array with equal spacing. The grooves of the lower support base (203) are either complete grooves capable of accommodating the sampling and ionization detection probes (204) or grooves that fit the lower support base (203) are formed on the bottom surface of the upper fixing cover plate (202). The grooves on the bottom surface of the upper fixing cover plate (202) and the grooves of the lower support base (203) form a complete groove capable of accommodating the sampling and ionization detection probes (204). The grooves are spaced at preset intervals. A screw hole is provided on the lower support base (203) of the array probe, which is a preset distance away from the groove. A screw hole matching the screw hole of the lower support base (203) of the array probe is also provided on the upper fixing cover plate (202) of the array probe. The upper fixing cover plate (202) of the array probe and the lower support base (203) of the array probe are detachably connected by the array probe fixing screw (201). The bottom of the lower support base (203) of the array probe assembly is provided with a protruding step structure. Based on the step structure, the array probe assembly (011) is introduced into the sample transfer assembly (003) to be tested. The array probe assembly clamping device specifically includes a transfer assembly spring-type pressing plate (303) provided at one end of the sample transfer assembly (003) to be tested. The array probe assembly (011) is clamped by the transfer assembly spring-type pressing plate (303).

6. The novel glove box based on a slide gate valve for sample introduction and transfer chamber according to claim 1, characterized in that, The self-locking rotary sampling head position adjustment mechanism is a multi-layer nested structure, including a self-locking rotary sampling head storage cavity, a position coarse adjustment device, and a linear telescopic precision adjustment component (103). The end of the array probe storage cavity (107) is connected to one end of the self-locking rotary sampling head storage cavity. The linear telescopic precision adjustment component (103) is installed at one end of the self-locking rotary sampling head storage cavity near the array probe storage cavity (107). The self-locking rotary sampling head (109) is connected to the output end of the magnetic support link rod (104). The storage cavity of the self-locking rotary sampling head (109) is specifically a magnetic support outer bracket. The position coarse adjustment device includes a magnetic external drive component (105). The magnetic external drive component (105) is sleeved on the outer wall of the magnetic support outer bracket. The magnetic external drive component (105) can slide linearly on the magnetic support outer bracket, synchronously driving the linear sliding of the internal magnetic rod.

7. A method of using the novel glove box based on the sample inlet connection and transfer chamber using a slide valve as described in any one of claims 1 to 6, characterized in that, Includes the following steps: Step 1: Open the sealing panel. Before opening, ensure that the external insert valve type glove box transition chamber (001) is at normal pressure. Place the sample transfer assembly (003) to be tested into the external insert valve type glove box transition chamber (001). Step 2: Cover the atmospheric side sealing panel of the external gate valve type glove box transition chamber (001) and close the sealing locking device at the same time. During this process, the gate valve at the front end is in a closed and sealed state, and the sealing panel inside the glove box is also in a closed state; after the glove box transition chamber shell is evacuated, a protective gas atmosphere is provided. Step 3: Based on the experimental requirements, complete the installation of the self-locking rotary sampling head (109) and the array probe assembly (011) to form a protective gas atmosphere inside the micro sample transfer chamber (007); Step 4: Connect the transfer sealing gate valve of the micro sample transfer chamber (007) to the gate valve of the gate valve type glove box. Step 5: Push the array probe assembly (011) located at the end of the self-locking rotary sampling head (109) out of the array probe storage cavity (107) by using the coarse adjustment and / or fine adjustment functions of the self-locking rotary sampling head (109) position adjustment mechanism. Step 6: Open the transfer sealing valve of the micro sample transfer chamber (007) and the valve of the valve-type glove box to transfer the array probe assembly (011) into the glove box.

8. The method according to claim 7, characterized in that, The magnetic internal connecting rod has three key positions. One is the initial position of the magnetic rod, at which time the array probe assembly (011) is installed. In the micro sample transfer chamber (007), the transfer chamber sealing valve (108) can be closed or opened, and the transfer chamber sealing valve (108) does not interfere with the array probe assembly (011). Secondly, by manually adjusting the external magnetic drive assembly (105), the internal magnetic connecting rod is transferred to the initial position of the precision adjustment component. At this time, the sample is detached from the array probe storage cavity (107) and located outside the transfer cavity sealing insert valve (108). Thirdly, fine adjustment begins. The rotation of the linear telescopic top rotating drive component drives the entire precision adjustment component to move downwards or upwards. When it moves downwards to the bottom of the fine adjustment component, it is at the longest position that the array sampling needle can extend.

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