Temperature automatic calibration system and method

Abstract

The present application belongs to the field of blood purification technology and relates to a temperature automatic calibration system and method, including a detachably connected liquid purification device and a calibration device, the liquid purification device including a heating element and a first temperature sensor connected to a control device, the heating element being used to heat the liquid in the heating chamber, the first temperature sensor being used to collect the current first temperature signal of the liquid at the inlet and / or outlet sides of the heating chamber, and feeding the first temperature signal back to the control device; the calibration device including a constant temperature liquid circulation device for simulating a target object, a second temperature sensor for collecting the actual second temperature signal of the liquid after heating at the outlet side of the heating chamber, and a temperature patrol meter for transmitting the second temperature signal to the control device; the present application not only facilitates the detection of heating devices of different liquid purification devices, but also can automatically switch calibration points according to predetermined flow rates from small to large for temperature calibration, with accurate and efficient calibration, simple operation and low cost.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a temperature automatic calibration system and method. Background Art

[0002] Blood purification equipment is a medical device that removes certain substances from the blood after it is drawn out of the body, removes waste, toxins, excess fluid, and other substances, and then returns the purified blood to the body to maintain internal environmental balance, including electrolyte and acid-base balance, thereby purifying the blood and treating diseases. Due to the need for blood to pass through a filter, heat loss from the air, and the low temperature of the infusion fluid, the temperature of the blood outside the body will inevitably drop. Therefore, blood purification equipment is usually equipped with a heating device to heat the purified blood after it is infused back into the patient, thereby maintaining the patient's normal body temperature as much as possible, promoting recovery, and preventing the danger of hypothermia.

[0003] In practice, the inventors discovered that due to inherent errors in the heating device and its built-in temperature sensor, blood purification equipment struggles to accurately heat the returned blood to the patient's normal body temperature, such as 37°C, before shipment or after a period of use. Therefore, prior to routine use, the heating device in the blood purification equipment must be calibrated to ensure that the returned blood reaches the appropriate temperature to ensure effective heating.

[0004] However, in the prior art, either manual calibration of the heating temperature is used, requiring the calibrator to manually input the actual temperature measurement value and monitor the calibration process throughout, which is time-consuming and labor-intensive, or expensive temperature detection devices are used for temperature control. However, in general, no matter which method is used, the calibration operation is relatively complicated and inefficient, and it is still difficult to ensure that the calibration result reaches and stably maintains the desired temperature value. Summary of the Invention

[0005] This application aims to solve at least one of the above-mentioned technical problems existing in the prior art.

[0006] In a first aspect, an embodiment of the present application provides a temperature automatic calibration system, which adopts the following technical solution:

[0007] The automatic temperature calibration system includes a liquid purification device and a calibration device, wherein the calibration device is detachably connected to the liquid purification device and is used to assist the liquid purification device in automatically calibrating the heating temperature of the purified liquid;

[0008] The liquid purification equipment comprises:

[0009] control devices;

[0010] a liquid purifier, connected to the target object via a first pipeline, and configured to purify liquid outputted by the target object;

[0011] a driving pump, provided in the first pipeline, electrically connected to the control device, and configured to provide driving force for inputting the target object into the liquid purifier; and

[0012] The heating device includes a body, wherein a heating chamber is formed in the body, and an inlet and an outlet are provided in communication with the heating chamber, wherein the inlet is used for inputting the liquid purified by the liquid purifier into the heating chamber; and the outlet is used for outputting the liquid in the heating chamber to be returned to the target object through a second pipeline.

[0013] The heating device further comprises:

[0014] a heating element, provided in the body and electrically connected to the control device, for heating the liquid in the heating chamber under the control of the control device; and

[0015] a first temperature sensor, electrically connected to the control device, for collecting a current first temperature signal of the liquid at the inlet and / or outlet of the heating chamber, and feeding the first temperature signal back to the control device;

[0016] Wherein, the calibration device comprises:

[0017] a constant temperature liquid circulation device, serving as the target object during temperature calibration, capable of circulating liquid internally while maintaining the target temperature; the constant temperature liquid circulation device being detachably connected to the drive pump via the first pipe and being detachably connected to the heating device via the second pipe;

[0018] A second temperature sensor is used to collect a second temperature signal of the liquid actually heated at the outlet of the heating chamber;

[0019] A temperature patrol meter is electrically connected to the second temperature sensor and the control device, and is used to transmit the second temperature signal to the control device so that the control device controls the liquid purification equipment to calibrate the first temperature signal according to the second temperature signal.

[0020] In some embodiments of the present application, the second temperature sensor is installed in the second pipeline, and the second temperature sensor includes a temperature measuring part, which is used to collect the actual second temperature signal of the heated liquid returned to the constant temperature liquid circulation device through the second pipeline.

[0021] In some embodiments of the present application, a temperature measuring hole is opened in the second pipeline at the outlet side of the heating device; the temperature measuring portion is closed and inserted into the temperature measuring hole to collect a second temperature signal of the heated liquid in the second pipeline;

[0022] Alternatively, the calibration device further comprises:

[0023] A three-way connector having a first interface, a second interface and a third interface that are interconnected; the first interface is connected to the outlet of the heating device through a joint and a section of the second pipeline in sequence, the second interface is connected to the constant temperature liquid circulation device through another section of the second pipeline, and the third interface is plugged with the temperature measuring part.

[0024] In some embodiments of the present application, the distance between the location of the temperature measuring portion and the outlet of the heating device is 1 cm to 2 cm;

[0025] And / or, the second temperature sensor further comprises a connecting wire, one end of the connecting wire is connected to the temperature measuring part, and the other end is connected to the temperature patrol meter;

[0026] The calibration device also includes:

[0027] The mounting tube has a first end and a second end that are in communication with each other; the first end of the mounting tube is connected to the third interface, and the second end is for the temperature measuring part to pass through and extend to the third interface and for part of the connecting line to extend into.

[0028] In some embodiments of the present application, the calibration device further includes a positioning clamp, the positioning clamp being used to clamp the connecting wire in the installation tube to assist in positioning the temperature measuring part at a target position;

[0029] And / or, the calibration device further comprises a packaging tube, one end of which is connected to the second end of the mounting tube, and the other end of which is for the connecting wire in the mounting tube to pass through and is encapsulated with a seal.

[0030] In some embodiments of the present application, the temperature patrol meter is a multi-channel temperature patrol meter, which is used to connect to multiple liquid purification devices at the same time;

[0031] Wherein, the temperature patrol meter is connected to the control device of each liquid purification device via a signal transmission line to transmit the second temperature signal collected by the corresponding second temperature sensor to the control device;

[0032] And / or, the liquid purification device is a blood purification device.

[0033] On the second aspect, in order to solve the above technical problems, the embodiment of the present application further provides a temperature calibration device, which adopts the following technical solution: the temperature calibration device adopts the calibration device of the above-mentioned automatic temperature calibration system.

[0034] Thirdly, to solve the above technical problems, the present application also provides a method for automatic temperature calibration, which adopts the following technical solution:

[0035] In the temperature automatic calibration method, N calibration points are provided, where N is a positive integer greater than or equal to 3; the predetermined flow rates corresponding to the N calibration points gradually increase, wherein the predetermined flow rate corresponding to the first current calibration point is the minimum predetermined flow rate; and the predetermined flow rate corresponding to the Nth current calibration point is the maximum predetermined flow rate;

[0036] The automatic temperature calibration method uses a calibration device to automatically calibrate the liquid returned from the liquid purification equipment, in sequence, at the predetermined flow rate corresponding to the N calibration points, and at the heating temperature of each calibration point;

[0037] The automatic temperature calibration method comprises:

[0038] Step S1: Calibration start step

[0039] Connecting the constant temperature liquid circulation device of the calibration device to the heating device and the liquid purifier of the liquid purification device to form a circulating liquid circuit; starting the calibration device and the liquid purification device, and heating the liquid in the constant temperature liquid circulation device to a standard temperature value T0 and then keeping it warm;

[0040] Step S2: Heating step according to the current target heating temperature value T1 at the current calibration point

[0041] The driving pump of the liquid purification device operates at a predetermined flow rate at the current calibration point, and the heating device heats the liquid purified by the liquid purifier according to the current target heating temperature value T1; wherein the initial flow rate of the current calibration point is the minimum predetermined flow rate; and the initial current target heating temperature value of each current calibration point is the default machine target heating temperature value of the device;

[0042] Step S3: Obtaining the actual heating temperature value

[0043] The second temperature sensor of the calibration device obtains the actual heating temperature value T2 of the return liquid at the outlet side of the heating device, and transmits the actual heating temperature to the control device of the liquid purification equipment;

[0044] Step S4: Compare the actual heating temperature value T2 with the standard temperature value T0

[0045] If the actual heating temperature value T2 is not within the preset temperature range, a calibration target heating temperature value T1' is obtained according to a preset calibration formula, and the current target heating temperature value T1 is updated to the calibration target heating temperature value T1'. Steps S2 to S4 are repeatedly performed in sequence using the predetermined flow rate at the current calibration point until the actual heating temperature value T2 is within the preset temperature range;

[0046] If the actual heating temperature value T2 is within the preset temperature range, further determining whether the actual heating temperature value T2 reaches the preset temperature range for the first time;

[0047] If so, stop heating and wait for the temperature to drop, then execute steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range for the second time;

[0048] If not, the actual heating temperature value T2 has reached the preset temperature range twice, then the calibration of the current calibration point is qualified, the current target heating temperature value in step S2 is saved as the final target heating temperature value of the current calibration point, the calibration of the current calibration point is completed, the current calibration point is switched to the next calibration point, and steps S2 to S4 are executed in sequence until the calibration of the Nth calibration point is completed;

[0049] Step S5: After the N calibration points are calibrated in sequence, the liquid purification equipment and the calibration device automatically stop.

[0050] In some embodiments of the present application, in step S3, the step of obtaining the actual heating temperature value T2 of the reinfused liquid specifically includes:

[0051] The second temperature sensor detects the liquid temperature at the outlet of the heating device in real time, and outputs the liquid temperature as the actual heating temperature value T2 when the error of the liquid temperature at the outlet is detected to be within a first preset time period and within a preset error range;

[0052] And / or, in step S4, the step of stopping heating and waiting for cooling specifically includes:

[0053] The heating device stops heating under the control of the control device;

[0054] The driving pump operates at the maximum predetermined flow rate for a second preset time period to cool the liquid outside the constant temperature liquid circulation device.

[0055] In some embodiments of the present application, the liquid purification device is a blood purification device;

[0056] And / or, the calibration formula in step S4 is as follows:

[0057] Calibration target heating temperature value T1' = calibration coefficient K * current target heating temperature value T1

[0058] Among them, the calibration coefficient K = standard temperature value T0 / actual heating temperature value T2;

[0059] And / or, the standard temperature value T0 is 37°C;

[0060] And / or, there are five calibration points, and the predetermined flow rates corresponding to the five calibration points are 15 ml / min, 80 ml / min, 160 ml / min, 200 ml / min, and 400 ml / min, respectively, wherein the minimum predetermined flow rate is 15 ml / min and the maximum predetermined flow rate is 400 ml / min;

[0061] And / or, the preset temperature range is 36.8°C to 37.2°C.

[0062] Compared with the prior art, the temperature automatic calibration system and method provided in the embodiments of the present application have the following advantages:

[0063] The temperature automatic calibration system is composed of a constant temperature liquid circulation device, a second temperature sensor, a temperature patrol meter, etc. to form an independent and complete calibration device, and the calibration device is detachably connected to the liquid purifier and heating device of the liquid purification equipment such as the blood purification equipment. It can not only facilitate the detection of the heating devices of different liquid purification equipment, but also realize the automatic calibration of the heating temperature of the heating device of the liquid purification equipment under the control of the control device through the cooperation of the first temperature sensor, the second temperature sensor, the temperature patrol meter, the heating element, the driving pump, etc., and can automatically switch the calibration points of different flow rates for temperature calibration. The temperature automatic calibration method can automatically switch the calibration points of different flow rates for temperature calibration, and automatically switch the calibration points according to the predetermined flow rate from small to large. In general, the present application makes full use of the existing structure and procedures of the liquid purification equipment on the basis of not changing or changing the liquid purification equipment as little as possible, and realizes temperature automatic calibration through the cooperation of the calibration device and the liquid purification equipment. The calibration operation is simple and reliable, which is conducive to improving the calibration efficiency and saving labor costs. At the same time, it is also conducive to reducing the calibration error and shortening the delivery time of the liquid purification equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0064] In order to more clearly illustrate the solutions in this application, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are some embodiments of this application or corresponding prior art. Those skilled in the art can also derive other drawings based on these drawings without inventive effort. Among them:

[0065] Figure 1This is a structural connection block diagram of a temperature automatic calibration system in an example of this application;

[0066] Figure 2 This is a simplified diagram of the basic structure of a blood purification device in an example of this application;

[0067] Figure 3 This is a connection diagram of an automatic temperature calibration system in an example of this application;

[0068] Figure 4 This is another connection diagram when the temperature automatic calibration system is working in an example of this application;

[0069] Figure 5 This is a schematic diagram of a three-dimensional structure in which a second temperature sensor in an automatic temperature calibration system in an example of the present application is connected to a heating device via a three-way connector;

[0070] Figure 6 is a schematic diagram of the three-dimensional structure of a second temperature sensor in a calibration device in an example of the present application;

[0071] Figure 7 This is a structural connection block diagram of a multi-channel temperature inspection instrument in an automatic temperature calibration system in an example of this application that can calibrate multiple liquid purification devices at the same time;

[0072] Figure 8 This is a flow chart of a method for automatic temperature calibration in an example of the present application for calibrating all calibration points;

[0073] Figure 9 This is a flow chart of calibrating a single calibration point in an automatic temperature calibration method in an example of the present application, wherein in the figure, the predetermined flow rate of the single calibration point is 15 ml / min.

[0074] The reference numerals in the accompanying drawings are as follows:

[0075] 1000. Automatic temperature calibration system;

[0076] 100. Liquid purification device / blood purification device; 110. First pipeline; 120. Drive pump; 130. Liquid purifier; 140. Heating device; 141. Main body; 1411. Heating chamber; 1412. Inlet; 1413. Outlet; 142. Heating element; 143. First temperature sensor; 150. Control device; 160. Display; 170. Memory; 180. Liquid level detector; 190. Second pipeline;

[0077] 200. Calibration device; 210. Constant temperature liquid circulation device; 220. Second temperature sensor; 221. Temperature measuring part / temperature measuring probe; 222. Connecting line; 230. Temperature patrol meter; 240. Three-way connector; 241. First interface; 242. Second interface; 243. Third interface; 250. Connector; 260. Mounting tube; 261. First end; 262. Second end; 270. Positioning clamp; 280. Packaging tube. DETAILED DESCRIPTION

[0078] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as commonly understood by those skilled in the art to which this application belongs. The terms used in this specification are for the purpose of describing specific embodiments only and are not intended to limit this application. For example, the directions or positions indicated by the terms "length", "width", "up", "down", "left", "right", "front", "back", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc. are based on the directions or positions shown in the accompanying drawings and are for ease of description only and should not be understood as limiting this technical solution.

[0079] The terms "including," "having," and any variations thereof in the specification, claims, and drawings of this application are intended to cover non-exclusive inclusions. The terms "first," "second," and the like in the specification, claims, and drawings of this application are used to distinguish between different items, not to describe a particular order. "Multiple" means two or more, unless otherwise expressly specified.

[0080] In the specification and claims of this application and the above-mentioned description of the drawings, when an element is referred to as being “fixed to,” “mounted on,” “disposed on,” or “connected to” another element, it may be directly or indirectly located on the other element. For example, when an element is referred to as being “connected to” another element, it may be directly or indirectly connected to the other element.

[0081] Furthermore, references to "embodiments" herein mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of such phrases in various locations in the specification does not necessarily refer to the same embodiment, nor do they constitute independent or alternative embodiments that are mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0082] An embodiment of the present application provides an automatic temperature calibration system 1000, which can be applied to a liquid purification device 100 to automatically calibrate the heating temperature of the liquid purification device 100. The liquid purification device 100 described herein includes, but is not limited to, a blood purification device 100. The liquid circulating in the liquid purification device 100 can be blood or other liquids, such as water. For ease of description, the following description primarily uses a blood purification device 100 as an example.

[0083] like Figure 1 、 Figure 3 and Figure 4 As shown, the automatic temperature calibration system 1000 includes a calibration device 200 and a liquid purification device 100. The calibration device 200 is detachably connected to the liquid purification device 100. The calibration device 200 is mainly used to assist the liquid purification device 100 in automatically calibrating the heating temperature of the purified liquid.

[0084] Taking the blood purification device 100 as an example, through the detachable connection between the calibration device 200 and the liquid purification device 100, the calibration device 200 can be reused as a whole, which makes it convenient to use the same calibration device 200 to calibrate the heating temperature of the liquid of the heating device 140 (specifically, a heating bag) of different blood purification devices 100 in succession. It is easy to disassemble and replace, which helps to reduce the cost of temperature calibration.

[0085] In the embodiments of the present application, Figure 1 As shown, the liquid purification device 100 includes a control device 150, a liquid purifier 130, a drive pump 120 and a heating device 140. For example, taking the blood purification device 100 as an example, the blood purification device 100 can apply different types of blood treatment modes, for example, a blood perfusion treatment mode, a blood dialysis treatment mode, etc. Under different blood treatment modes, the type of blood purifier will also be different, for example, it can be a blood perfusion device, a dialyzer, etc. or a combination thereof, so there are correspondingly multiple ways of connecting the pipes in the blood purification device 100. But in general, the basic structures of different types of blood purification devices 100 are basically the same (see Figure 2 ), specifically as follows:

[0086] like Figure 2 and Figure 3As shown, the liquid purifier 130 is connected to the target object via the first pipeline 110 and is used to purify the liquid output by the target object. It should be noted that the target object herein can be a human body, other biological body, or other suitable non-biological body, and the specific details are not particularly limited here. It is only necessary that the liquid in the target object can maintain a constant temperature inside the target object, and after connecting to the liquid purification device 100, the internal liquid can be transported to the liquid purification device 100 for liquid purification, and the purified liquid can be returned to the target object.

[0087] The drive pump 120 is disposed in the first conduit 110 and electrically connected to the control device 150. The drive pump 120 can be used to provide a driving force for the liquid of the target object to be input into the liquid purifier 130. Under the control of the control device 150, the drive pump 120 is positioned between the target object and the liquid purifier 130. The drive pump 120 causes the liquid outputted from the target object through the first conduit 110 to be input into the liquid purifier 130 at different flow rates. This facilitates providing different flow rates according to the different needs of the patient, improves the patient's comfort, and facilitates the automatic temperature calibration system 1000 to automatically calibrate different calibration points.

[0088] For example Figure 3 and Figure 5 As shown, the heating device 140 includes a body 141, which is formed with a heating chamber 1411, an inlet 1412, and an outlet 1413. The inlet 1412 and the outlet 1413 are both in communication with the heating chamber 1411. The inlet 1412 can be used to allow liquid purified by the liquid purifier 130 to enter the heating chamber 1411; the outlet 1413 can be used to allow the liquid in the heating chamber 1411 to be discharged and returned to the target object through the second pipeline 190. It should be noted that in the liquid purification device 100, the connection between the outlet 1413 and the target object is not limited to the second pipeline 190, and other suitable components can also be provided.

[0089] For example, in the blood purification device 100, the first pipeline 110 is typically an arterial pipeline. One end of the first pipeline 110 can be connected to a human artery and the other end can be connected to the blood input end of the blood purifier. The drive pump 120 (which can be a blood pump, specifically a peristaltic pump) is disposed in the middle portion of the first pipeline 110. The second pipeline 190 is typically a venous pipeline. One end of the second pipeline 190 can be connected to the blood output end of the blood purifier and the other end can be connected to a human vein. The second pipeline 190 can be composed of multiple segments connected to allow for the connection of other functional components.

[0090] like Figure 1As shown, the heating device 140 further includes a heating element 142 and a first temperature sensor 143. The heating element 142 is disposed within the body 141 and electrically connected to the control device 150. The first temperature sensor 143 is electrically connected to the control device 150. The heating element 142 can be used to heat the liquid within the heating chamber 1411 under the control of the control device 150. For example, the control device 150 can adjust the heating temperature of the heating element 142 through pulse width modulation (PWM), causing the temperature to increase or decrease, thereby allowing the liquid within the heating chamber 1411 to reach a target heating temperature. Furthermore, for example, the body 141 of the heating device 140 can be a bag, that is, the heating device 140 can be a heating bag. The interior of the heating bag can have a tubular structure such as a coiled or reciprocating zigzag shape. The heating element 142 can be attached to the outer wall of the heating bag to heat the bag. The heating bag is heated by the electrical heating, thereby heating the liquid flowing within the heating bag.

[0091] In addition, the first temperature sensor 143 is used to collect the current first temperature signal of the liquid on the inlet and / or outlet side of the heating chamber 1411, and feed the first temperature signal back to the control device 150. It should be noted that the first temperature value T1 corresponding to the first temperature signal described herein has an initial value that is the machine temperature value of the program default in the liquid purification equipment 100. The initial first temperature values ​​of the following different calibration points may be the same or different. Due to the error in equipment manufacturing, this automatic temperature calibration system 1000 mainly calibrates the initial first temperature value corresponding to each calibration point to ensure that the temperature of the liquid returned to the target object is within the preset temperature range.

[0092] It should also be noted that if Figure 1 As shown, the liquid purification device 100 may also generally include a memory 170, a display 160 and a liquid level detector 180. The memory 170, the display 160 and the liquid level detector 180 are all connected to the control device 150, wherein the memory 170 can be used to store computer programs and various data, the control device 150 can be used to execute computer programs, and the display 160 can realize interactive communication under the control of the control device 150. For example, the user can directly operate and click "Start" on the display 160 to directly instruct each component to start running after the temperature automatic calibration system 1000 is connected to complete the automatic calibration of the temperature. In addition, the liquid level detector 180 is used to detect the liquid level of the liquid in the liquid flow circuit and feed the data back to the control device 150. When the liquid level is too high, the control device 150 can control the drive pump 120 to reduce the flow rate to reduce the liquid in the venous line.

[0093] In the embodiments of the present application, Figure 1 、 Figure 3 and Figure 4As shown, the calibration device 200 includes a constant temperature liquid circulation device 210, a second temperature sensor 220, and a temperature patrol meter 230. The constant temperature liquid circulation device 210 is detachably connected to the driving pump 120 of the liquid purification device 100 via a first pipeline 110, and is detachably connected to the heating device 140 of the liquid purification device 100 via a second pipeline 190. During temperature calibration, the constant temperature liquid circulation device 210 can simulate the target object during the daily operation of the liquid purification device 100 and can circulate liquid internally while maintaining the target temperature T0.

[0094] Exemplarily, the constant temperature liquid circulation device 210 may be a constant temperature water tank, which can be used to simulate the human blood system. The constant temperature water tank can be connected to the first pipeline 110 (corresponding to the arterial pipeline) and the second pipeline 190 (corresponding to the venous pipeline). During the automatic temperature calibration process, the constant temperature water tank can supply water reaching the human body temperature of 37°C to the blood purifier, and the internal water temperature is maintained at 37°C. In this way, water can be used to simulate blood circulation through the blood purifier, the heating device 140, and the human blood circulation system under the drive of the blood pump.

[0095] Understandably, when the calibration device 200 assists the blood purification device 100 in performing heating temperature calibration, the circulating liquid used by the automatic temperature calibration system 1000 can be blood used in the daily operation of the blood purification device 100, or other types of liquids such as water. Specifically, in this embodiment, the constant temperature liquid circulation device 210 is directly used as the target object to simulate the human body, which helps save resources and simplify the calibration operation.

[0096] Additionally, the second temperature sensor 220 can be used to collect a second temperature signal representing the actual temperature of the heated liquid at the outlet of the heating chamber 1411. It should be noted that the second temperature value T2 corresponding to the second temperature signal described herein represents the actual temperature of the heated return liquid. It is understood that if this actual temperature value significantly differs from the target temperature T0 of the constant temperature liquid circulation device 210 and is outside the preset temperature range, the first temperature value T1 corresponding to the first temperature signal will need to be calibrated.

[0097] For example Figure 1 As shown, the temperature patrol meter 230 is electrically connected to the second temperature sensor 220 and the control device 150, and is used to transmit the second temperature signal to the control device 150, so that the control device 150 controls the liquid purification equipment 100 to calibrate the first temperature signal according to the second temperature signal.

[0098] It can be understood that the working principle of the automatic temperature calibration system 1000 is as follows: the automatic temperature calibration system 1000 simulates the human blood system by using the constant temperature liquid circulation device 210. Before the liquid purification equipment 100 leaves the factory or before daily use, the constant temperature liquid circulation device 210 can be detachably connected to the liquid purifier 130 and the heating device 140, thereby cooperating with the liquid purification equipment 100 to form the automatic temperature calibration system 1000; after startup, the first temperature sensor 143 of the heating device 140 can collect the first temperature value T1 obtained by heating the liquid by the machine temperature value defaulted by the application, and feed the first temperature value T1 back to the control device 150;

[0099] In addition, the second temperature sensor 220 of the calibration device 200 can directly collect the actual second temperature value T2 of the liquid after being heated by the heating element 142 at the outlet side of the heating chamber 1411, and feed back the second temperature value T2 to the control device 150 through the temperature patrol meter 230. The control device 150 compares T2 with the target temperature T0 of the constant temperature liquid circulation device 210. If T2 is within the error temperature range of T0, there is no need to calibrate the first temperature value T1. If T2 is not within the error temperature range of T0, the first temperature value T1 needs to be calibrated until T2 is within the error temperature range of T0, and the original first temperature value T1 is updated to the latest first temperature value T1'. In this way, in daily use in the future, the heating element 142 is controlled to heat with the latest first temperature value T1', thereby ensuring that the temperature of the liquid returned to the target object can meet the user's expected temperature; in addition, the control device 150 controls the drive pump 120 to make the liquid run at different flow rates, so as to automatically calibrate the heating temperature of the liquid at different flow rates.

[0100] In summary, compared with the prior art, the automatic temperature calibration system 1000 has at least the following beneficial effects:

[0101] The temperature automatic calibration system 1000 is composed of a constant temperature liquid circulation device 210, a second temperature sensor 220, a temperature patrol meter 230 and the like, and the calibration device 200 is detachably connected to the liquid purifier 130 and the heating device 140 of the liquid purification device 100, which can not only facilitate the detection of the heating device 140 of different liquid purification devices 100, but also can be controlled by the first temperature sensor 143, the second temperature sensor 220, the temperature patrol meter 230, the heating element 142, the driving pump 140 and the like under the control of the control device 150. 20, etc., the heating temperature of the heating device 140 of the liquid purification equipment 100 can be automatically calibrated, and the calibration points of different flow rates can be automatically switched for temperature calibration, so that the existing structure and procedures of the liquid purification equipment 100 can be fully utilized without changing or changing the liquid purification equipment 100 as little as possible. Through the cooperation of the calibration device 200 and the liquid purification equipment 100, automatic temperature calibration can be achieved, and the calibration operation is simple and reliable, which is conducive to improving calibration efficiency and saving labor costs. At the same time, it is also conducive to reducing calibration errors and shortening the delivery time of the liquid purification equipment 100.

[0102] In order to make the technical personnel in this field better understand the present application scheme, the following Figures 1 to 7 , clearly and completely describe the technical solutions in the embodiments of this application.

[0103] In some embodiments of the present application, Figure 1 and Figure 3 As shown, on the outlet side of the heating chamber 1411 of the heating device 140, a second temperature sensor 220 is installed on the second pipeline 190, and the second temperature sensor 220 includes a temperature measuring part 221, wherein the temperature measuring part 221 can be used to collect the actual second temperature signal of the heated liquid returned to the constant temperature liquid circulation device 210 through the second pipeline 190.

[0104] Optionally, the temperature measuring part 221 is a temperature sensing probe; the second temperature sensor 220 can be optionally a thermistor temperature sensor, which also includes a connecting line 222, wherein one end of the connecting line 222 is connected to the temperature sensing probe, and the other end is connected to the temperature patrol meter 230. The second temperature signal collected by the temperature sensing probe can be transmitted to the temperature patrol meter 230 through the connecting line 222.

[0105] It can be understood that by installing a second temperature sensor 220 on the outlet side of the heating chamber 1411 of the heating device 140, the water temperature measured by the second temperature sensor 220 can be closer to the constant temperature liquid circulation device 210 (corresponding to the human body end), so that the temperature of the heated reinfused blood under actual use conditions can be more realistically simulated.

[0106] There are at least two specific implementations for installing the second temperature sensor 220 on the second pipeline 190 at the outlet side of the heating device 140:

[0107] In a first specific embodiment, a temperature measuring hole (not shown) is provided in the second pipe 190 at the outlet side of the heating device 140; a temperature measuring portion 221 is inserted into the temperature measuring hole in a sealed manner to collect a second temperature signal of the heated liquid in the second pipe 190. For example, a temperature measuring hole is provided axially in the second pipe 190, and a temperature probe of the second temperature sensor 220 is inserted into the temperature measuring hole to detect the temperature of the heated liquid in the second pipe 190. It should be noted that the temperature sensing probe can directly block the temperature measuring hole to prevent water leakage; in addition, the size of the temperature sensing probe should not be too large to reduce the impact of the temperature sensing probe on the liquid flow rate, thereby reducing the impact of the flow rate of the heated liquid in the second pipe 190 on the temperature detection results.

[0108] Alternatively, in a second embodiment, Figure 1 and Figure 5 As shown, the calibration device 200 further includes a three-way connector 240, which has a first interface 241, a second interface 242 and a third interface 243 (see FIG. Figure 5 ), wherein the first interface 241 is connected to the outlet 1413 of the heating device 140 via a connector 250 and a section of the second pipeline 190 in sequence, the second interface 242 is connected to the constant temperature liquid circulation device 210 via another section of the second pipeline 190, and the third interface 243 is plugged with a temperature measuring portion 221. It is understandable that the temperature measuring portion 221 of the second temperature sensor 220 does not enter the second pipeline 190, but directly exits the third interface 243 that communicates with the second pipeline 190 to detect the temperature of the heated liquid in the second pipeline 190. This avoids extending the temperature measuring portion 221 into the second pipeline 190, thereby reducing the impact of the temperature measuring portion 221 on the liquid flow rate in the circuit. Furthermore, it avoids directly opening a hole in the second pipeline 190, thereby preventing atmospheric circulation from affecting the liquid flow rate in the second pipeline 190. This minimizes the impact of the temperature measuring mounting structure of the second temperature sensor 220 on the liquid flow rate, thereby facilitating accurate calibration of calibration points with different flow rates.

[0109] In some embodiments of the present application, the distance between the temperature measuring portion 221 of the second temperature sensor 220 and the outlet 1413 of the heating device 140 is 1 cm to 2 cm, so that the temperature of the heated return liquid measured by the second temperature sensor 220 is closer to the actual usage state.

[0110] and / or, such as Figure 5 and Figure 6As shown, the second temperature sensor 220 also includes a connecting line 222, wherein one end of the connecting line 222 is connected to the temperature measuring part 221, and the other end is connected to the temperature patrol meter 230. In this way, the second temperature signal collected by the temperature measuring part 221 can be transmitted to the temperature patrol meter 230 through the connecting line 222.

[0111] For example Figure 5 As shown, to ensure the secure installation of the second temperature sensor 220, the calibration device 200 further includes a mounting tube 260 having a first end 261 and a second end 262. The first end 261 of the mounting tube 260 is connected to the third port 243 of the three-way connector 240, while the second end 262 of the mounting tube 260 allows the temperature measuring portion 221 of the second temperature sensor 220 to pass through and extend to the third port 243, and allows a portion of the connecting wire 222 to extend therethrough. It is understood that the temperature measuring portion 221 of the second temperature sensor 220 and the connecting wire 222 connected thereto can extend into the mounting tube 260 from the second end 262 of the mounting tube 260. To measure the temperature of the heated liquid, the temperature measuring portion 221 passes through the mounting tube 260 and enters the third port 243. The end of the connecting wire 222, which is closest to the temperature probe 230, is exposed outside the mounting tube 260 and can be connected to the temperature probe 230.

[0112] Optionally, to further ensure the installation stability of the second temperature sensor 220 and to facilitate ensuring the accuracy and safety of temperature detection, the calibration device 200 further includes a positioning clamp 270, wherein the positioning clamp 270 can be used to clamp the connecting wire 222 in the mounting tube 260 to assist in positioning the temperature measuring portion 221 at the target position. For example, the mounting tube 260 is a hose, and the positioning clamp 270 clamps the connecting wire 222 in the mounting tube 260 to prevent the connecting wire 222 from moving and further extending into or out of the mounting tube 260, thereby fixing the temperature measuring portion 221 of the second temperature sensor 220 at the detection position of the third interface 243 of the three-way connector 240, ensuring accurate detection of the water temperature at the outlet 1413 of the heating device 140.

[0113] And / or, optionally, in order to further improve the installation stability and safety of the second temperature sensor 220, the calibration device 200 also includes a packaging tube 280, wherein one end of the packaging tube 280 (specifically, the head end) is connected to the second end 262 of the mounting tube 260, and the other end of the packaging tube 280 (specifically, the tail end) is for the connecting wire 222 in the mounting tube 260 to pass through and is encapsulated with a seal.

[0114] For example, the packaging tube 280 is a rigid tube. The end of the connecting wire 222 closest to the temperature probe 230 passes through the mounting tube 260 and the packaging tube 280, respectively, to connect to the temperature probe 230. The opening at the rear end of the packaging tube 280 is larger than the opening at the front end. This facilitates the injection of glass glue into the rear end of the packaging tube 280, ensuring a sealed fluid circuit and effectively reducing the risk of water leakage.

[0115] In some embodiments of the present application, Figure 7 As shown, the temperature patrol meter 230 is a multi-channel temperature patrol meter 230, which can be used to connect to multiple liquid purification devices 100 at the same time.

[0116] Among them, the temperature patrol meter 230 is connected to the control device 150 of each liquid purification device 100 via a signal transmission line to transmit the second temperature signal collected by the corresponding second temperature sensor 220 to the control device 150. It can be understood that multiple calibration devices 200 can share a multi-channel temperature patrol meter 230. Specifically, the second temperature sensor 220 of each calibration device 200 is connected to the same multi-channel temperature patrol meter 230 via a corresponding connection line 222; and multiple liquid purification devices 100 also share a multi-channel temperature patrol meter 230. Specifically, the control device 150 of each liquid purification device 100 is connected to the same multi-channel patrol meter via a corresponding signal transmission line. This is conducive to improving calibration efficiency, saving calibration time, and shortening the delivery time of the liquid purification device 100.

[0117] For example, the temperature patrol meter 230 can be a 16-channel temperature patrol meter 230, that is, 16 calibration devices 200 can share a temperature patrol meter 230 to simultaneously perform temperature calibration on 16 devices. Of course, in other embodiments, the number of channels of the temperature patrol meter 230 can be other, depending on actual needs.

[0118] The present embodiment further provides a temperature calibration device 200, which is the calibration device 200 in the aforementioned automatic temperature calibration system 1000. Overall, the temperature calibration device 200 has a simple structure, low cost, simple calibration operation, and accurate calibration, which facilitates widespread application.

[0119] The present application also provides an automatic temperature calibration method, wherein N calibration points are provided, where N is a positive integer greater than or equal to 3. The predetermined flow rates corresponding to the N calibration points gradually increase, wherein the predetermined flow rate corresponding to the first current calibration point is the minimum predetermined flow rate, and the predetermined flow rate corresponding to the Nth current calibration point is the maximum predetermined flow rate. It should be noted that the specific values ​​of the predetermined flow rates corresponding to the N calibration points can be determined based on actual needs, as long as they can be gradually increased in sequence.

[0120] In an embodiment of the present application, the automatic temperature calibration method utilizes a calibration device 200 to automatically calibrate the liquid returned from the liquid purification apparatus 100, sequentially at the predetermined flow rates corresponding to N calibration points, and at the heating temperature of each calibration point. Understandably, this automatic temperature calibration method automatically switches calibration points sequentially at predetermined flow rates from smallest to largest for temperature calibration. This, on the one hand, avoids omissions and facilitates orderly calibration; on the other hand, it reduces the impact of the temperature retained from the previous calibration point on the heating of the next calibration point, thereby improving calibration accuracy.

[0121] For example, in some specific implementations of this embodiment, there may be 5 calibration points, that is, N=5. Taking the liquid purification device 100 as a blood purification device 100 as an example, the predetermined flow rates corresponding to the 5 calibration points may be 15ml / min, 80ml / min, 160ml / min, 200ml / min, and 400ml / min, respectively. Obviously, the predetermined flow rate of the first calibration point is the minimum predetermined flow rate of 15ml / min, and the predetermined flow rate of the fifth calibration point is the maximum predetermined flow rate of 400ml / min. Of course, in other specific implementations, the specific flow rate of the predetermined flow rate corresponding to each calibration point may adopt other values. For the convenience of description, the following will be explained by taking the 5 calibration points as an example.

[0122] In the embodiments of the present application, Figure 8 and Figure 9 As shown, the temperature automatic calibration method includes the following:

[0123] Step S1 is a calibration start step. Step S1 includes:

[0124] Step S11: Connect the constant temperature liquid circulation device 210 of the calibration device 200 to the heating device 140 and the liquid purifier of the liquid purification equipment 100 to form a circulating liquid circuit.

[0125] Optionally, when the temperature patrol meter 230 is a single-channel temperature patrol meter 230, Figure 1 The structure shown connects the calibration device 200 to the liquid purification equipment 100 in a detachable manner; when the temperature patrol meter 230 is a multi-channel temperature patrol meter 230, it can be connected according to Figure 7 The structure shown detachably connects a plurality of calibration devices 200 to a plurality of liquid purification equipment 100 to form a plurality of circulating liquid circuits.

[0126] Step S12: Start the calibration device 200 and the liquid purification equipment 100, and heat the liquid in the constant temperature liquid circulation device 210 to a standard temperature value T0 and then keep it warm.

[0127] For example, the constant temperature liquid circulation device 210 can be a constant temperature water tank with a standard temperature value T0 of 37°C. The constant temperature water tank, liquid purification equipment 100, and temperature monitoring instrument 230 are started, and the water in the constant temperature water tank is heated to 37°C and then kept warm in preparation for calibration. Then, click "Start" on the display 160 of the liquid purification equipment 100 to begin calibration of the current calibration point. The predetermined flow rate for the initial calibration point is the minimum predetermined flow rate, for example, the predetermined flow rate of 15 ml / min for the first calibration point mentioned above.

[0128] Step S2 is a step of heating at the current target heating temperature value T1 at the current calibration point. Step S2 includes:

[0129] The driving pump 120 of the liquid purification device 100 operates at a predetermined flow rate of the current calibration point, and the heating device 140 heats the liquid purified by the liquid purifier according to the current target heating temperature value T1.

[0130] The initial flow rate of the current calibration point is the minimum predetermined flow rate; the initial current target heating temperature value of each current calibration point is the default machine target heating temperature value of the device.

[0131] For example, taking the above-mentioned 5 calibration points as an example, in step S2, the initial current calibration point, that is, the calibration point that is first calibrated, corresponds to a predetermined flow rate of 15 ml / min, and the initial target heating temperature value T1 at the predetermined flow rate of 15 ml / min is the default machine target heating temperature value of the blood purification device 100. If, during calibration, it is detected that the initial target heating temperature value T1 does not meet expectations, the target heating temperature value T1 needs to be updated to a new target heating temperature value T1' to calibrate the target heating temperature value T1. If several tests still fail to meet expectations, the current target heating temperature value T1 needs to be continuously updated until the heating temperature of the heated liquid meets expectations, and the corresponding current target heating temperature value T1 or T1' that meets expectations is used as the target heating temperature value corresponding to the predetermined flow rate of the current calibration point when the blood purification device 100 is actually working.

[0132] Step S3 is a step of obtaining the actual heating temperature value. Step S3 includes:

[0133] The second temperature sensor 220 of the calibration device 200 obtains the actual heating temperature value T2 of the return liquid at the outlet side of the heating device 140 and transmits the actual heating temperature to the control device 150 of the liquid purification equipment 100 .

[0134] In some specific embodiments of the present application, in step S3, the step of obtaining the actual heating temperature value T2 of the reinfused liquid specifically includes:

[0135] The second temperature sensor 220 detects the liquid temperature at the outlet 1413 of the heating device 140 in real time. When it is detected that the error of the liquid temperature at the outlet 1413 is within the first preset time length and remains within the preset error range, the liquid temperature is output as the actual heating temperature value T2.

[0136] It is understandable that the liquid temperature detected by the second temperature sensor 220 at the outlet 1413 of the heating device 140 may change frequently. Only when the error of a certain temperature changes within the preset error range and is maintained for the first preset time, can the temperature be used as the actual heating temperature value T2 and fed back to the control device 150 by the temperature patrol meter 230. Otherwise, the temperature patrol meter 230 will not feed back to the control device 150.

[0137] Optionally, in some specific embodiments of the present application, the first preset time length may be 2 minutes, and the preset error range may be ±0.2° C. Of course, in other specific embodiments, the first preset time length and the preset error range may also be other appropriate values, which are not particularly limited here.

[0138] Step S4 is a step of comparing the actual heating temperature value T2 with the standard temperature value T0. Figure 8 and Figure 9 As shown, step S4 includes:

[0139] If the actual heating temperature value T2 detected in step S3 is not within the preset temperature range, the calibration target heating temperature value T1' is obtained according to the preset calibration formula, and the current target heating temperature value T1 in step S2 is updated to the calibration target heating temperature value T1', and the predetermined flow rate of the current calibration point is used to repeat steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range.

[0140] Optionally, the liquid purification device 100 may be a blood purification device 100. In this case, in order to adapt to the human blood system and ensure the treatment effect of the patient, the standard temperature value T0 is 37°C, and the preset temperature range is 36.8°C to 37.2°C.

[0141] In addition, the calibration formula in step S4 can be as follows:

[0142] Calibration target heating temperature value T1' = calibration coefficient K * current target heating temperature value T1

[0143] Wherein, the calibration coefficient K=standard temperature value T0 / actual heating temperature value T2.

[0144] Exemplarily, if the actual heating temperature value T2 detected by the second temperature sensor 220 in step S4 is not within the range of 36.8°C to 37.2°C, for example, T2 is 37.5°C, it indicates that the current target heating temperature value T1 in step S2 is too high. Then, it is necessary to calibrate through the calibration formula to obtain T1'. In this case, T1' < T1, and the control device 150 can control the heating temperature of the heating element 142 to be updated from T1 to T1', thereby reducing the heating temperature of the heating element 142. On the contrary, it indicates that the current target heating temperature value T1 in step S2 is too low, and it is necessary to calibrate to a higher T1'. At this time, T1' > T1, and the control device 150 can control the heating temperature of the heating element 142 to be updated from T1 to T1', thereby increasing the heating temperature of the heating element 142.

[0145] If the actual heating temperature value T2 is within the preset temperature range, it is further determined whether the actual heating temperature value T2 reaches the preset temperature range for the first time.

[0146] See, for example Figure 8 and Figure 9 , if so, stop heating and wait for cooling, and then sequentially execute steps S2 to step S4 until the actual heating temperature value T2 is within the preset temperature range for the second time.

[0147] It can be understood that if it is detected that the actual heating temperature value T2 only reaches the preset temperature range for the first time, it still cannot ensure that the heating element 142 is heated according to the current target heating temperature value T1. Whether the actual heating temperature value T2 obtained during actual operation is within the preset temperature range. Therefore, it is still necessary to further verify whether the current target heating temperature value T1 in step S2 can be used as the target heating temperature value adopted during actual operation at the current calibration point of the liquid purification device 100.

[0148] In some specific embodiments of the present application, as Figure 8 and Figure 9 shown, in step S4, the step of stopping heating and waiting for cooling specifically includes:

[0149] The heating device 140 stops heating under the control of the control device 150.

[0150] The driving pump 120 operates at the maximum predetermined flow rate for a second preset duration to cool the liquid outside the constant temperature liquid circulation device 210.

[0151] It can be understood that if it is detected that the actual heating temperature value T2 only reaches the preset temperature range for the first time, it is necessary to quickly dissipate the heat of the feedback liquid and prepare for the second heating to check whether the actual heating temperature value T2 can be used as the target heating temperature value adopted during actual operation at the current calibration point of the liquid purification device 100.

[0152] If not, the actual heating temperature value T2 has reached the preset temperature range twice, then the calibration of the current calibration point is qualified, and the current target heating temperature value in step S2 is saved as the final target heating temperature value of the current calibration point. The calibration of the current calibration point is completed, and the current calibration point is switched to the next calibration point, and then steps S2 to S4 are executed in sequence until the calibration of the Nth calibration point is completed.

[0153] Optionally, the maximum predetermined flow rate may be the predetermined flow rate corresponding to the fifth standard point mentioned above, 400 ml / min, and the second preset time length may be 1 minute. For example, when it is determined that T2 detected in step S3 is within the range of 36.8°C to 37.2°C, the control device 150 controls the heating element 142 to stop heating, and controls the drive pump 120 to run at 400ml / min for 1 minute for cooling, so as to remove the heat at the calibration point, such as the predetermined flow rate of 15ml / min, through a large flow rate, to avoid the result of the subsequent second calibration being affected by it, and then controls the drive pump 120 to run at 15ml / min, and controls the heating element 142 to reheat the liquid according to the current target heating temperature value T1 or T1', and judges whether the actual heating temperature value T2 detected again by the second temperature sensor 220 is within 36.8°C to 37.2°C. If so, it means that it reaches 36.8°C to 37.2°C for the second time, and saves the current target heating temperature value T1 or T1' at the 15ml / min standard point as the target heating temperature value used when the blood purification equipment 100 actually works at the 15ml / min standard point. At this point, the calibration at the 15ml / min standard point is completed.

[0154] Then, the control device 150 can control the driving pump 120 to run at 80ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the 80ml / min standard point is completed, the control device 150 can control the driving pump 120 to run at 160ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the 160ml / min standard point is completed, the control device 150 can control the driving pump 120 to run at 200ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the 200ml / min standard point is completed, the control device 150 can control the driving pump 120 to run at 400ml / min, and then execute steps S2 to S4 in sequence; after the calibration at the 400ml / min standard point is completed, step S5 can be entered.

[0155] Step S5: After the N calibration points are calibrated sequentially, the liquid purification equipment 100 and the calibration device 200 automatically stop.

[0156] For example, after N calibration points have been calibrated sequentially, the display 160 of the liquid purification device 100 may display a message indicating calibration completion. After the user clicks "Confirm," the liquid purification device 100 and calibration device 200 automatically stop. It should be noted that this automatic temperature calibration method can be implemented using the aforementioned automatic temperature calibration system 1000 and is also the calibration method for the aforementioned automatic temperature calibration system 1000.

[0157] In summary, compared with the existing technology, this automatic temperature calibration method has at least the following beneficial effects:

[0158] This automatic temperature calibration method automatically switches between calibration points at different flow rates for temperature calibration, improving the calibration efficiency of liquid purification equipment and saving labor costs. It also helps reduce calibration errors and shortens the time it takes for liquid purification equipment to ship. Furthermore, by automatically switching calibration points according to predetermined flow rates, from small to large, it avoids missing calibration points and reduces the impact of the temperature retained from the previous calibration point on the heating of the current calibration point, thereby improving calibration accuracy.

[0159] The foregoing is merely a preferred embodiment of the present application and is not intended to limit the present application. Various modifications and variations are possible for those skilled in the art. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application should be included within the scope of the claims of the present application.

Claims

1. A temperature automatic calibration system, characterized in that: The automatic temperature calibration system includes a liquid purification device and a calibration device, wherein the calibration device is detachably connected to the liquid purification device and is used to assist the liquid purification device in automatically calibrating the heating temperature of the purified liquid; The liquid purification equipment comprises: control devices; a liquid purifier, connected to the target object via a first pipeline, and configured to purify liquid outputted by the target object; a driving pump, provided in the first pipeline, electrically connected to the control device, and configured to provide driving force for inputting the target object into the liquid purifier; and The heating device includes a body, wherein a heating chamber is formed in the body, and an inlet and an outlet are provided in communication with the heating chamber, wherein the inlet is used for inputting the liquid purified by the liquid purifier into the heating chamber; and the outlet is used for outputting the liquid in the heating chamber to be returned to the target object through a second pipeline. The heating device further comprises: a heating element, provided in the body and electrically connected to the control device, for heating the liquid in the heating chamber under the control of the control device; and a first temperature sensor, electrically connected to the control device, for collecting a current first temperature signal of the liquid at the inlet and / or outlet of the heating chamber, and feeding the first temperature signal back to the control device; Wherein, the calibration device comprises: a constant temperature liquid circulation device, serving as the target object during temperature calibration, capable of circulating liquid internally while maintaining the target temperature; the constant temperature liquid circulation device being detachably connected to the drive pump via the first pipe and being detachably connected to the heating device via the second pipe; A second temperature sensor is used to collect a second temperature signal of the liquid actually heated at the outlet of the heating chamber; A temperature patrol meter is electrically connected to the second temperature sensor and the control device, and is used to transmit the second temperature signal to the control device so that the control device controls the liquid purification equipment to calibrate the first temperature signal according to the second temperature signal.

2. The automatic temperature calibration system according to claim 1, characterized in that: The second temperature sensor is installed in the second pipeline. The second temperature sensor includes a temperature measuring part, which is used to collect the actual second temperature signal of the heated liquid returned to the constant temperature liquid circulation device through the second pipeline.

3. The automatic temperature calibration system according to claim 2, characterized in that: A temperature measuring hole is provided in the second pipeline at the outlet side of the heating device; the temperature measuring portion is inserted into the temperature measuring hole in a closed manner to collect a second temperature signal of the heated liquid in the second pipeline; Alternatively, the calibration device further comprises: A three-way connector having a first interface, a second interface and a third interface that are interconnected; The first interface is connected to the outlet of the heating device through a joint and a section of the second pipeline in sequence, the second interface is connected to the constant temperature liquid circulation device through another section of the second pipeline, and the third interface is plugged with the temperature measuring part.

4. The automatic temperature calibration system according to claim 3, characterized in that: The distance between the temperature measuring part and the outlet of the heating device is 1 cm to 2 cm; And / or, the second temperature sensor further comprises a connecting wire, one end of the connecting wire is connected to the temperature measuring part, and the other end is connected to the temperature patrol meter; The calibration device also includes: The mounting tube has a first end and a second end that are in communication with each other; the first end of the mounting tube is connected to the third interface, and the second end is for the temperature measuring part to pass through and extend to the third interface and for part of the connecting line to extend into.

5. The automatic temperature calibration system according to claim 4, characterized in that: The calibration device further includes a positioning clamp, which is used to clamp the connecting wire in the installation tube to assist in positioning the temperature measuring part at a target position; And / or, the calibration device further comprises a packaging tube, one end of which is connected to the second end of the mounting tube, and the other end of which is for the connecting wire in the mounting tube to pass through and is encapsulated with a seal.

6. The automatic temperature calibration system according to any one of claims 1 to 5, characterized in that: The temperature patrol meter is a multi-channel temperature patrol meter, which is used to connect to multiple liquid purification devices at the same time; Wherein, the temperature patrol meter is connected to the control device of each liquid purification device via a signal transmission line to transmit the second temperature signal collected by the corresponding second temperature sensor to the control device; And / or, the liquid purification device is a blood purification device.

7. A temperature calibration device, characterized in that: The temperature calibration device adopts the calibration device according to any one of claims 1 to 6.

8. A temperature automatic calibration method, characterized in that: In the temperature automatic calibration method, N calibration points are provided, where N is a positive integer greater than or equal to 3; the predetermined flow rates corresponding to the N calibration points gradually increase, wherein the predetermined flow rate corresponding to the first current calibration point is the minimum predetermined flow rate; and the predetermined flow rate corresponding to the Nth current calibration point is the maximum predetermined flow rate; The automatic temperature calibration method uses a calibration device to automatically calibrate the liquid returned from the liquid purification equipment, in sequence, at the predetermined flow rate corresponding to the N calibration points, and at the heating temperature of each calibration point; The automatic temperature calibration method comprises: Step S1: Calibration start step Connecting the constant temperature liquid circulation device of the calibration device to the heating device and the liquid purifier of the liquid purification device to form a circulating liquid circuit; starting the calibration device and the liquid purification device, and heating the liquid in the constant temperature liquid circulation device to a standard temperature value T0 and then keeping it warm; Step S2: Heating step according to the current target heating temperature value T1 at the current calibration point The driving pump of the liquid purification device operates at a predetermined flow rate at the current calibration point, and the heating device heats the liquid purified by the liquid purifier according to the current target heating temperature value T1; wherein the initial flow rate of the current calibration point is the minimum predetermined flow rate; and the initial current target heating temperature value of each current calibration point is the default machine target heating temperature value of the device; Step S3: Obtaining the actual heating temperature value The second temperature sensor of the calibration device obtains the actual heating temperature value T2 of the return liquid at the outlet side of the heating device, and transmits the actual heating temperature to the control device of the liquid purification equipment; Step S4: Compare the actual heating temperature value T2 with the standard temperature value T0 If the actual heating temperature value T2 is not within the preset temperature range, a calibration target heating temperature value T1' is obtained according to a preset calibration formula, and the current target heating temperature value T1 is updated to the calibration target heating temperature value T1'. Steps S2 to S4 are repeatedly performed in sequence using the predetermined flow rate at the current calibration point until the actual heating temperature value T2 is within the preset temperature range; If the actual heating temperature value T2 is within the preset temperature range, further determining whether the actual heating temperature value T2 reaches the preset temperature range for the first time; If so, stop heating and wait for the temperature to drop, then execute steps S2 to S4 in sequence until the actual heating temperature value T2 is within the preset temperature range for the second time; If not, the actual heating temperature value T2 has reached the preset temperature range twice, then the calibration of the current calibration point is qualified, the current target heating temperature value in step S2 is saved as the final target heating temperature value of the current calibration point, the calibration of the current calibration point is completed, the current calibration point is switched to the next calibration point, and steps S2 to S4 are executed in sequence until the calibration of the Nth calibration point is completed; Step S5: After the N calibration points are calibrated in sequence, the liquid purification equipment and the calibration device automatically stop.

9. The automatic temperature calibration method according to claim 8, characterized in that: In step S3, the step of obtaining the actual heating temperature value T2 of the reinfused liquid specifically includes: The second temperature sensor detects the liquid temperature at the outlet of the heating device in real time, and outputs the liquid temperature as the actual heating temperature value T2 when the error of the liquid temperature at the outlet is detected to be within a first preset time period and within a preset error range; And / or, in step S4, the step of stopping heating and waiting for cooling specifically includes: The heating device stops heating under the control of the control device; The driving pump operates at the maximum predetermined flow rate for a second preset time period to cool the liquid outside the constant temperature liquid circulation device.

10. The automatic temperature calibration method according to claim 8 or 9, characterized in that: The liquid purification device is a blood purification device; And / or, the calibration formula in step S4 is as follows: Calibration target heating temperature value T1' = calibration coefficient K * current target heating temperature value T1 Among them, the calibration coefficient K = standard temperature value T0 / actual heating temperature value T2; And / or, the standard temperature value T0 is 37°C; And / or, there are five calibration points, and the predetermined flow rates corresponding to the five calibration points are 15 ml / min, 80 ml / min, 160 ml / min, 200 ml / min, and 400 ml / min, respectively, wherein the minimum predetermined flow rate is 15 ml / min and the maximum predetermined flow rate is 400 ml / min; And / or, the preset temperature range is 36.8°C to 37.2°C.

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